IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Ndufa4

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4

(Aliases: MLRQ)

Entrez: 17992
Ensembl: ENSMUSG00000029632
UniProtKB: Q62425

Process Predictions
Disease Predictions

Ndufa4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
oxidation reduction process	GO:0055114	342	0.596
atp metabolic process	GO:0046034	75	0.458
nucleoside triphosphate metabolic process	GO:0009141	230	0.448
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.418
purine ribonucleoside metabolic process	GO:0046128	241	0.394
ribonucleotide metabolic process	GO:0009259	291	0.383
nucleoside metabolic process	GO:0009116	246	0.333
purine nucleoside metabolic process	GO:0042278	241	0.311
nucleoside phosphate metabolic process	GO:0006753	338	0.307
nucleoside monophosphate metabolic process	GO:0009123	85	0.305
glycosyl compound metabolic process	GO:1901657	246	0.302
purine containing compound metabolic process	GO:0072521	311	0.275
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.264
nucleobase containing small molecule metabolic process	GO:0055086	352	0.249
purine nucleotide metabolic process	GO:0006163	302	0.248
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.235
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.193
nucleotide metabolic process	GO:0009117	332	0.192
transmembrane transport	GO:0055085	412	0.184
carbohydrate derivative catabolic process	GO:1901136	231	0.168
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.153
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.149
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.144
aromatic compound catabolic process	GO:0019439	286	0.141
purine ribonucleotide metabolic process	GO:0009150	290	0.140
ribonucleotide catabolic process	GO:0009261	208	0.134
nucleoside triphosphate catabolic process	GO:0009143	205	0.127
ribose phosphate metabolic process	GO:0019693	291	0.119
nucleoside catabolic process	GO:0009164	206	0.114
energy derivation by oxidation of organic compounds	GO:0015980	77	0.112
atp catabolic process	GO:0006200	55	0.111
purine ribonucleotide catabolic process	GO:0009154	208	0.104
cellular respiration	GO:0045333	38	0.103
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.098
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.093
purine containing compound catabolic process	GO:0072523	213	0.078
nucleoside monophosphate catabolic process	GO:0009125	59	0.077
intracellular protein transport	GO:0006886	204	0.071
ribonucleoside catabolic process	GO:0042454	206	0.067
nucleotide catabolic process	GO:0009166	217	0.065
ion transmembrane transport	GO:0034220	361	0.064
purine nucleoside catabolic process	GO:0006152	205	0.060
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.058
cytoplasmic transport	GO:0016482	234	0.057
negative regulation of cell proliferation	GO:0008285	296	0.052
glycosyl compound catabolic process	GO:1901658	206	0.051
nucleoside phosphate catabolic process	GO:1901292	222	0.051
organophosphate catabolic process	GO:0046434	232	0.048
organonitrogen compound catabolic process	GO:1901565	264	0.045
purine nucleotide catabolic process	GO:0006195	211	0.042
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.041
protein maturation	GO:0051604	176	0.040
organic cyclic compound catabolic process	GO:1901361	295	0.039
cellular nitrogen compound catabolic process	GO:0044270	280	0.037
establishment of protein localization to organelle	GO:0072594	118	0.036
cation transport	GO:0006812	399	0.036
positive regulation of mapk cascade	GO:0043410	170	0.034
endocytosis	GO:0006897	168	0.034
cation transmembrane transport	GO:0098655	266	0.032
regulation of kinase activity	GO:0043549	249	0.032
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.032
negative regulation of organelle organization	GO:0010639	90	0.032
protein localization to organelle	GO:0033365	185	0.032
mitochondrial transport	GO:0006839	36	0.031
regulation of body fluid levels	GO:0050878	162	0.030
apoptotic signaling pathway	GO:0097190	306	0.030
regulation of mapk cascade	GO:0043408	248	0.029
purine ribonucleoside catabolic process	GO:0046130	205	0.029
inorganic ion transmembrane transport	GO:0098660	234	0.029
myeloid cell differentiation	GO:0030099	233	0.029
negative regulation of cellular component organization	GO:0051129	194	0.027
protein processing	GO:0016485	163	0.027
regulation of establishment of protein localization	GO:0070201	181	0.026
microtubule cytoskeleton organization	GO:0000226	157	0.026
cellular response to molecule of bacterial origin	GO:0071219	83	0.026
substantia nigra development	GO:0021762	2	0.025
regulation of protein serine threonine kinase activity	GO:0071900	157	0.024
regulation of nucleocytoplasmic transport	GO:0046822	73	0.024
cellular response to lipid	GO:0071396	145	0.024
ribonucleoside metabolic process	GO:0009119	245	0.024
nitrogen compound transport	GO:0071705	271	0.023
mitochondrion organization	GO:0007005	134	0.023
reactive oxygen species metabolic process	GO:0072593	84	0.023
protein import into nucleus	GO:0006606	95	0.022
generation of precursor metabolites and energy	GO:0006091	103	0.022
extrinsic apoptotic signaling pathway	GO:0097191	126	0.022
positive regulation of transferase activity	GO:0051347	167	0.022
spermatogenesis	GO:0007283	284	0.022
placenta development	GO:0001890	140	0.022
cell type specific apoptotic process	GO:0097285	268	0.022
cellular response to oxidative stress	GO:0034599	76	0.021
muscle contraction	GO:0006936	101	0.021
regulation of protein localization	GO:0032880	231	0.021
leukocyte differentiation	GO:0002521	342	0.021
cognition	GO:0050890	149	0.021
mapk cascade	GO:0000165	281	0.021
protein targeting	GO:0006605	143	0.021
myeloid cell homeostasis	GO:0002262	114	0.020
microtubule based process	GO:0007017	236	0.020
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.019
protein import	GO:0017038	101	0.019
male gamete generation	GO:0048232	285	0.019
wound healing	GO:0042060	157	0.018
inorganic cation transmembrane transport	GO:0098662	207	0.018
lymphocyte differentiation	GO:0030098	242	0.018
determination of adult lifespan	GO:0008340	11	0.018
learning or memory	GO:0007611	148	0.018
multicellular organismal aging	GO:0010259	24	0.018
amide transport	GO:0042886	138	0.017
regulation of cytoplasmic transport	GO:1903649	112	0.017
positive regulation of kinase activity	GO:0033674	155	0.017
regulation of protein kinase activity	GO:0045859	232	0.017
positive regulation of protein modification process	GO:0031401	299	0.017
multi multicellular organism process	GO:0044706	109	0.016
nuclear import	GO:0051170	95	0.016
regulation of hydrolase activity	GO:0051336	246	0.016
innate immune response	GO:0045087	157	0.016
regulation of lymphocyte activation	GO:0051249	240	0.016
negative regulation of leukocyte differentiation	GO:1902106	51	0.016
membrane organization	GO:0061024	245	0.016
response to organic cyclic compound	GO:0014070	198	0.016
gonad development	GO:0008406	141	0.016
regulation of secretion	GO:0051046	274	0.016
inflammatory response	GO:0006954	244	0.015
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.015
negative regulation of molecular function	GO:0044092	258	0.015
nucleocytoplasmic transport	GO:0006913	139	0.015
positive regulation of protein phosphorylation	GO:0001934	242	0.014
response to lipopolysaccharide	GO:0032496	128	0.014
cellular ion homeostasis	GO:0006873	165	0.014
homeostasis of number of cells	GO:0048872	210	0.014
regulation of cellular component biogenesis	GO:0044087	181	0.014
regulation of cellular amino acid metabolic process	GO:0006521	5	0.014
nuclear transport	GO:0051169	139	0.014
regulation of response to wounding	GO:1903034	189	0.014
regulation of cell activation	GO:0050865	289	0.014
regulation of intracellular transport	GO:0032386	159	0.014
cellular ketone metabolic process	GO:0042180	84	0.014
heterocycle catabolic process	GO:0046700	280	0.014
regulation of organelle organization	GO:0033043	289	0.014
carbohydrate derivative biosynthetic process	GO:1901137	183	0.014
cellular protein complex assembly	GO:0043623	116	0.014
extracellular structure organization	GO:0043062	148	0.013
hydrogen ion transmembrane transport	GO:1902600	25	0.013
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.013
cellular response to biotic stimulus	GO:0071216	92	0.013
regulation of peptidase activity	GO:0052547	96	0.013
leukocyte proliferation	GO:0070661	172	0.013
regulation of apoptotic signaling pathway	GO:2001233	197	0.013
cellular lipid metabolic process	GO:0044255	323	0.013
protein localization to membrane	GO:0072657	108	0.013
response to oxygen levels	GO:0070482	62	0.013
carboxylic acid transport	GO:0046942	100	0.013
peptide transport	GO:0015833	133	0.013
epithelial cell proliferation	GO:0050673	174	0.013
positive regulation of protein kinase activity	GO:0045860	144	0.013
development of primary sexual characteristics	GO:0045137	143	0.013
zymogen activation	GO:0031638	41	0.013
anion transport	GO:0006820	177	0.013
negative regulation of lipopolysaccharide mediated signaling pathway	GO:0031665	3	0.012
neuron death	GO:0070997	154	0.012
negative regulation of lymphocyte activation	GO:0051250	91	0.012
4 hydroxyproline metabolic process	GO:0019471	5	0.012
regulation of protein targeting	GO:1903533	61	0.012
amine metabolic process	GO:0009308	45	0.012
regulation of cellular ketone metabolic process	GO:0010565	66	0.012
regulation of proteolysis	GO:0030162	164	0.012
dna metabolic process	GO:0006259	303	0.012
locomotory behavior	GO:0007626	195	0.012
cellular amino acid metabolic process	GO:0006520	103	0.012
multicellular organismal homeostasis	GO:0048871	164	0.012
organonitrogen compound biosynthetic process	GO:1901566	192	0.012
regulation of t cell activation	GO:0050863	170	0.012
neuron apoptotic process	GO:0051402	142	0.012
adult behavior	GO:0030534	135	0.012
cellular response to lipopolysaccharide	GO:0071222	77	0.012
regulation of neuron differentiation	GO:0045664	281	0.012
regulation of protein transport	GO:0051223	163	0.012
single organism nuclear import	GO:1902593	95	0.012
synaptic transmission	GO:0007268	329	0.011
regulation of cellular response to stress	GO:0080135	159	0.011
cellular homeostasis	GO:0019725	240	0.011
negative regulation of t cell activation	GO:0050868	65	0.011
regulation of neuron death	GO:1901214	134	0.011
signal transduction in absence of ligand	GO:0038034	55	0.011
positive regulation of camp mediated signaling	GO:0043950	3	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.011
regulation of lymphocyte differentiation	GO:0045619	107	0.011
t cell activation	GO:0042110	289	0.011
regulation of ion transport	GO:0043269	215	0.011
chemotaxis	GO:0006935	247	0.011
lymphocyte proliferation	GO:0046651	164	0.011
epidermis development	GO:0008544	187	0.011
response to radiation	GO:0009314	165	0.010
thymus development	GO:0048538	41	0.010
response to hypoxia	GO:0001666	58	0.010
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.010
regulation of transferase activity	GO:0051338	263	0.010
regulation of leukocyte differentiation	GO:1902105	159	0.010
myeloid leukocyte differentiation	GO:0002573	119	0.010
skin development	GO:0043588	220	0.010
regulation of secretion by cell	GO:1903530	249	0.010

Ndufa4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.032
disease of anatomical entity	DOID:7	0.032
disease of metabolism	DOID:0014667	0.028
inherited metabolic disorder	DOID:655	0.028

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