IMP: Integrative Multi-species Prediction

Mus musculus

101 known processes

P2rx2

purinergic receptor P2X, ligand-gated ion channel, 2

(Aliases: MGC129149,MGC129148,P2x2,P2X2a)

Entrez: 231602
Ensembl: ENSMUSG00000029503
UniProtKB: Q8K3P1

Process Predictions
Disease Predictions

P2rx2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cofactor transport	GO:0051181	4	0.517	Mouse
multicellular organismal protein metabolic process	GO:0044268	2	0.476	Mouse
phospholipid transfer to membrane	GO:0006649	2	0.354	Mouse
regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling	GO:0003027	1	0.351
purinergic nucleotide receptor signaling pathway	GO:0035590	3	0.345	Mouse
positive regulation of gamma aminobutyric acid secretion	GO:0014054	2	0.285	Mouse
insemination	GO:0007320	6	0.228	Mouse
regulation of gamma aminobutyric acid secretion	GO:0014052	2	0.187	Mouse
blood circulation	GO:0008015	195	0.181
regulation of anatomical structure size	GO:0090066	178	0.176	Mouse
reactive oxygen species biosynthetic process	GO:1903409	8	0.168
reactive nitrogen species metabolic process	GO:2001057	0	0.159
cellular lipid metabolic process	GO:0044255	323	0.158	Mouse
muscle system process	GO:0003012	141	0.156
cation transport	GO:0006812	399	0.153
positive regulation of t cell mediated cytotoxicity	GO:0001916	15	0.148	Mouse
positive regulation of protein modification process	GO:0031401	299	0.139	Mouse
positive regulation of cell death	GO:0010942	224	0.134	Mouse
sphingolipid biosynthetic process	GO:0030148	26	0.126	Mouse
membrane lipid biosynthetic process	GO:0046467	32	0.122	Mouse
membrane organization	GO:0061024	245	0.121	Mouse
positive regulation of amino acid transport	GO:0051957	4	0.120	Mouse
regulation of vascular smooth muscle contraction	GO:0003056	1	0.120	Mouse
regulation of interleukin 1 alpha secretion	GO:0050705	3	0.117	Mouse
positive regulation of glutamate secretion	GO:0014049	2	0.112	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.107	Mouse
regulation of secretion	GO:0051046	274	0.107	Mouse
skeletal system development	GO:0001501	356	0.105	Mouse
regulation of system process	GO:0044057	200	0.105	Mouse
urinary bladder smooth muscle contraction	GO:0014832	5	0.103
circulatory system process	GO:0003013	197	0.102
detection of stimulus	GO:0051606	84	0.102
positive regulation of apoptotic process	GO:0043065	217	0.099	Mouse
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.098	Mouse
sensory perception of mechanical stimulus	GO:0050954	107	0.097
regulation of interleukin 1 alpha production	GO:0032650	4	0.096	Mouse
regulation of blood circulation	GO:1903522	93	0.096	Mouse
urinary tract smooth muscle contraction	GO:0014848	6	0.096
sequestering of metal ion	GO:0051238	19	0.095	Mouse
synapse organization	GO:0050808	125	0.094
calcium ion homeostasis	GO:0055074	127	0.089	Mouse
regulation of membrane potential	GO:0042391	192	0.088	Mouse
regulation of transferase activity	GO:0051338	263	0.085	Mouse
membrane lipid metabolic process	GO:0006643	53	0.082	Mouse
sensory perception of sound	GO:0007605	97	0.081
sensory perception of pain	GO:0019233	47	0.080	Mouse
cell type specific apoptotic process	GO:0097285	268	0.078	Mouse
regulation of postsynaptic membrane potential	GO:0060078	48	0.076	Mouse
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.076	Mouse
negative regulation of phosphorylation	GO:0042326	166	0.076	Mouse
organelle assembly	GO:0070925	177	0.075	Mouse
apoptotic signaling pathway	GO:0097190	306	0.075	Mouse
synaptic transmission	GO:0007268	329	0.075
multicellular organismal signaling	GO:0035637	91	0.075
cytokine production	GO:0001816	319	0.074	Mouse
positive regulation of cell development	GO:0010720	237	0.072
phagosome maturation	GO:0090382	4	0.070	Mouse
muscle cell differentiation	GO:0042692	261	0.070
striated muscle tissue development	GO:0014706	293	0.067
organophosphate ester transport	GO:0015748	28	0.067	Mouse
regulation of protein kinase activity	GO:0045859	232	0.066	Mouse
transmission of nerve impulse	GO:0019226	76	0.065
phagolysosome assembly	GO:0001845	3	0.065	Mouse
cellular homeostasis	GO:0019725	240	0.065	Mouse
lipid biosynthetic process	GO:0008610	179	0.064	Mouse
organonitrogen compound biosynthetic process	GO:1901566	192	0.063	Mouse
nitrogen compound transport	GO:0071705	271	0.062	Mouse
lysosome organization	GO:0007040	21	0.062	Mouse
ion transmembrane transport	GO:0034220	361	0.061
establishment of organelle localization	GO:0051656	122	0.061	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.061
vacuole organization	GO:0007033	38	0.061	Mouse
regulation of metal ion transport	GO:0010959	106	0.060	Mouse
cell adhesion	GO:0007155	329	0.060
cellular metal ion homeostasis	GO:0006875	151	0.059	Mouse
protein oligomerization	GO:0051259	67	0.059	Mouse
lymphocyte mediated immunity	GO:0002449	139	0.059	Mouse
lymphocyte homeostasis	GO:0002260	64	0.059	Mouse
phospholipid transport	GO:0015914	21	0.057	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.056	Mouse
cellular response to lipid	GO:0071396	145	0.056
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.056	Mouse
t cell homeostasis	GO:0043029	35	0.055	Mouse
regulation of endopeptidase activity	GO:0052548	89	0.055	Mouse
regulation of blood pressure	GO:0008217	93	0.053
positive regulation of peptidase activity	GO:0010952	49	0.053	Mouse
positive regulation of kinase activity	GO:0033674	155	0.053	Mouse
sequestering of calcium ion	GO:0051208	18	0.053	Mouse
skeletal system morphogenesis	GO:0048705	203	0.052	Mouse
leukocyte mediated immunity	GO:0002443	174	0.052	Mouse
calcium ion transport	GO:0006816	159	0.051	Mouse
nucleobase containing compound transport	GO:0015931	27	0.051	Mouse
endomembrane system organization	GO:0010256	147	0.051	Mouse
amine metabolic process	GO:0009308	45	0.051
regulation of cellular ketone metabolic process	GO:0010565	66	0.049
multicellular organismal macromolecule catabolic process	GO:0044266	1	0.049	Mouse
multi multicellular organism process	GO:0044706	109	0.049	Mouse
neuronal action potential	GO:0019228	54	0.049
t cell activation	GO:0042110	289	0.048	Mouse
positive regulation of nervous system development	GO:0051962	221	0.048
regulation of homeostatic process	GO:0032844	182	0.048	Mouse
positive regulation of proteolysis	GO:0045862	85	0.048	Mouse
lymphocyte apoptotic process	GO:0070227	54	0.048	Mouse
lytic vacuole organization	GO:0080171	21	0.048	Mouse
skeletal muscle organ development	GO:0060538	163	0.048
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.048	Mouse
macromolecule catabolic process	GO:0009057	281	0.047	Mouse
regulation of cellular component biogenesis	GO:0044087	181	0.046
divalent metal ion transport	GO:0070838	172	0.046	Mouse
dna metabolic process	GO:0006259	303	0.045
inflammatory response	GO:0006954	244	0.045	Mouse
regulation of lymphocyte apoptotic process	GO:0070228	41	0.044	Mouse
sensory perception	GO:0007600	245	0.044
plasma membrane organization	GO:0007009	90	0.043	Mouse
positive regulation of interleukin 1 alpha production	GO:0032730	4	0.043	Mouse
positive regulation of map kinase activity	GO:0043406	84	0.043	Mouse
metal ion homeostasis	GO:0055065	189	0.043	Mouse
response to hypoxia	GO:0001666	58	0.041
regulation of neuron projection development	GO:0010975	169	0.041
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.041
response to pain	GO:0048265	26	0.041
regulation of map kinase activity	GO:0043405	120	0.041	Mouse
cellular chemical homeostasis	GO:0055082	215	0.041	Mouse
protein catabolic process	GO:0030163	221	0.040	Mouse
positive regulation of cytokine production	GO:0001819	174	0.040	Mouse
homeostasis of number of cells	GO:0048872	210	0.040	Mouse
purinergic receptor signaling pathway	GO:0035587	7	0.039	Mouse
cellular calcium ion homeostasis	GO:0006874	119	0.039	Mouse
adaptive immune response	GO:0002250	155	0.039	Mouse
regulation of mitochondrial membrane potential	GO:0051881	17	0.039	Mouse
leukocyte mediated cytotoxicity	GO:0001909	62	0.038	Mouse
actin cytoskeleton organization	GO:0030036	220	0.038
positive regulation of mapk cascade	GO:0043410	170	0.038	Mouse
serotonin secretion involved in inflammatory response	GO:0002442	4	0.038	Mouse
regulation of t cell mediated cytotoxicity	GO:0001914	18	0.038	Mouse
regulation of interleukin 6 production	GO:0032675	55	0.038	Mouse
protein maturation	GO:0051604	176	0.037	Mouse
action potential	GO:0001508	78	0.037
regulation of leukocyte mediated immunity	GO:0002703	104	0.037	Mouse
positive regulation of lymphocyte apoptotic process	GO:0070230	13	0.037	Mouse
regulation of body fluid levels	GO:0050878	162	0.037	Mouse
regulation of ion transport	GO:0043269	215	0.036	Mouse
positive regulation of interleukin 6 production	GO:0032755	37	0.036	Mouse
protein homooligomerization	GO:0051260	43	0.036
positive regulation of transferase activity	GO:0051347	167	0.035	Mouse
cell killing	GO:0001906	67	0.035	Mouse
regulation of cytokine production	GO:0001817	266	0.035	Mouse
negative regulation of phosphorus metabolic process	GO:0010563	184	0.034	Mouse
leukocyte differentiation	GO:0002521	342	0.034
regulation of protein serine threonine kinase activity	GO:0071900	157	0.033	Mouse
regulation of secretion by cell	GO:1903530	249	0.033	Mouse
amine transport	GO:0015837	21	0.033	Mouse
regulation of ion homeostasis	GO:2000021	64	0.033	Mouse
cellular ketone metabolic process	GO:0042180	84	0.033
positive regulation of cell killing	GO:0031343	33	0.033	Mouse
axonogenesis	GO:0007409	274	0.032
dendrite development	GO:0016358	115	0.032
negative regulation of nervous system development	GO:0051961	156	0.032
phagocytosis	GO:0006909	66	0.032	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.031
glutamate secretion	GO:0014047	8	0.031	Mouse
asymmetric stem cell division	GO:0098722	3	0.031
cellular amine metabolic process	GO:0044106	44	0.031
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.031	Mouse
regulation of organelle organization	GO:0033043	289	0.031
regulation of excitatory postsynaptic membrane potential	GO:0060079	41	0.030	Mouse
regulation of mapk cascade	GO:0043408	248	0.030	Mouse
ossification	GO:0001503	216	0.030	Mouse
regulation of leukocyte mediated cytotoxicity	GO:0001910	38	0.030	Mouse
spermatogenesis	GO:0007283	284	0.030
regulation of cell killing	GO:0031341	40	0.030	Mouse
leukocyte proliferation	GO:0070661	172	0.030	Mouse
synaptic vesicle transport	GO:0048489	57	0.029	Mouse
regulation of calcium ion transport	GO:0051924	69	0.029	Mouse
negative regulation of cell development	GO:0010721	169	0.029
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.029	Mouse
regulation of muscle contraction	GO:0006937	49	0.028	Mouse
multicellular organismal response to stress	GO:0033555	62	0.028
protein localization to membrane	GO:0072657	108	0.028
regulation of hydrolase activity	GO:0051336	246	0.028	Mouse
leukocyte homeostasis	GO:0001776	79	0.028	Mouse
gamma aminobutyric acid secretion	GO:0014051	6	0.028	Mouse
muscle cell development	GO:0055001	133	0.027
negative regulation of molecular function	GO:0044092	258	0.027
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.027
blood vessel morphogenesis	GO:0048514	285	0.027
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.027	Mouse
fatty acid metabolic process	GO:0006631	121	0.027
phospholipid translocation	GO:0045332	9	0.027	Mouse
positive regulation of interleukin 1 alpha secretion	GO:0050717	3	0.027	Mouse
ear development	GO:0043583	200	0.027
activation of mapk activity	GO:0000187	59	0.026	Mouse
positive regulation of interleukin 1 beta production	GO:0032731	16	0.026	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.026
neurohypophysis development	GO:0021985	2	0.026
vesicle organization	GO:0016050	60	0.026	Mouse
forebrain development	GO:0030900	302	0.026
divalent inorganic cation homeostasis	GO:0072507	138	0.026	Mouse
regulation of membrane lipid distribution	GO:0097035	16	0.026	Mouse
response to lipopolysaccharide	GO:0032496	128	0.026	Mouse
striated muscle cell development	GO:0055002	125	0.025
positive regulation of amine transport	GO:0051954	8	0.025	Mouse
gamma aminobutyric acid transport	GO:0015812	7	0.025	Mouse
response to metal ion	GO:0010038	47	0.025	Mouse
detection of hypoxic conditions in blood by chemoreceptor signaling	GO:0002007	1	0.025
male gamete generation	GO:0048232	285	0.025
cellular response to hormone stimulus	GO:0032870	150	0.025
peptide metabolic process	GO:0006518	46	0.025
nucleobase containing small molecule metabolic process	GO:0055086	352	0.025
muscle tissue development	GO:0060537	308	0.025
sensory system development	GO:0048880	3	0.025
regulation of muscle system process	GO:0090257	80	0.024	Mouse
cell recognition	GO:0008037	83	0.024
oxidation reduction process	GO:0055114	342	0.024
defense response to gram positive bacterium	GO:0050830	50	0.024	Mouse
hormone secretion	GO:0046879	128	0.024
regulation of cell adhesion	GO:0030155	154	0.024
developmental maturation	GO:0021700	193	0.024
morphogenesis of a branching epithelium	GO:0061138	193	0.024
organelle fission	GO:0048285	170	0.024
protein processing	GO:0016485	163	0.023	Mouse
positive regulation of organelle organization	GO:0010638	128	0.023
response to organonitrogen compound	GO:0010243	246	0.023
response to molecule of bacterial origin	GO:0002237	143	0.023	Mouse
cation homeostasis	GO:0055080	212	0.023	Mouse
cellular ion homeostasis	GO:0006873	165	0.023	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.023	Mouse
exocytosis	GO:0006887	121	0.023	Mouse
innate immune response	GO:0045087	157	0.023
regulation of hormone levels	GO:0010817	211	0.023
regionalization	GO:0003002	337	0.023
reactive oxygen species metabolic process	GO:0072593	84	0.023	Mouse
positive regulation of hydrolase activity	GO:0051345	148	0.023	Mouse
inorganic ion transmembrane transport	GO:0098660	234	0.023
embryonic skeletal system development	GO:0048706	120	0.023
regulation of protein localization	GO:0032880	231	0.023	Mouse
leukocyte apoptotic process	GO:0071887	71	0.022	Mouse
response to acid chemical	GO:0001101	111	0.022
interleukin 1 alpha production	GO:0032610	5	0.022	Mouse
regulation of neuron differentiation	GO:0045664	281	0.022
myotube differentiation	GO:0014902	105	0.022
transmembrane transport	GO:0055085	412	0.022
stem cell development	GO:0048864	219	0.022
wound healing	GO:0042060	157	0.022	Mouse
protein localization to plasma membrane	GO:0072659	57	0.022
negative regulation of intracellular signal transduction	GO:1902532	167	0.022	Mouse
endocytosis	GO:0006897	168	0.022	Mouse
meiotic cell cycle process	GO:1903046	77	0.022
regulation of interleukin 1 beta production	GO:0032651	25	0.022	Mouse
regulation of protein secretion	GO:0050708	82	0.021	Mouse
protein kinase b signaling	GO:0043491	74	0.021
regulation of lipid transport	GO:0032368	36	0.021	Mouse
response to inorganic substance	GO:0010035	96	0.021	Mouse
muscle contraction	GO:0006936	101	0.021
wnt signaling pathway	GO:0016055	188	0.021
detection of chemical stimulus	GO:0009593	16	0.021
negative regulation of protein metabolic process	GO:0051248	282	0.021
pole plasm assembly	GO:0007315	2	0.021
lymphocyte proliferation	GO:0046651	164	0.021	Mouse
positive regulation of ion transport	GO:0043270	65	0.020	Mouse
negative regulation of immune system process	GO:0002683	209	0.020
carbohydrate homeostasis	GO:0033500	128	0.020
tissue homeostasis	GO:0001894	115	0.020	Mouse
gland development	GO:0048732	330	0.020
multicellular organismal homeostasis	GO:0048871	164	0.020	Mouse
regulation of blood vessel size	GO:0050880	56	0.020	Mouse
purine nucleoside metabolic process	GO:0042278	241	0.020
positive regulation of adaptive immune response	GO:0002821	61	0.020	Mouse
bone development	GO:0060348	120	0.020
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.020	Mouse
actin filament organization	GO:0007015	113	0.020
response to heat	GO:0009408	27	0.020	Mouse
digestive system development	GO:0055123	200	0.020
positive regulation of neuron differentiation	GO:0045666	141	0.019
carbohydrate metabolic process	GO:0005975	230	0.019
monocarboxylic acid metabolic process	GO:0032787	191	0.019
regulation of cellular amino acid metabolic process	GO:0006521	5	0.019
regulation of establishment of protein localization	GO:0070201	181	0.019	Mouse
cation transmembrane transport	GO:0098655	266	0.019
regulation of cell motility	GO:2000145	236	0.019
detection of molecule of bacterial origin	GO:0032490	2	0.019
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.019	Mouse
negative regulation of neuron differentiation	GO:0045665	101	0.019
immune effector process	GO:0002252	321	0.018	Mouse
tube formation	GO:0035148	140	0.018
protein digestion	GO:0044256	1	0.018	Mouse
copulation	GO:0007620	7	0.018	Mouse
sensory organ morphogenesis	GO:0090596	242	0.018
inorganic cation transmembrane transport	GO:0098662	207	0.018
membrane depolarization	GO:0051899	64	0.018	Mouse
response to extracellular stimulus	GO:0009991	127	0.018	Mouse
regulation of systemic arterial blood pressure	GO:0003073	61	0.018
regulation of systemic arterial blood pressure by chemoreceptor signaling	GO:0001979	1	0.018
small gtpase mediated signal transduction	GO:0007264	97	0.018
cartilage development	GO:0051216	140	0.018
oocyte construction	GO:0007308	2	0.018
lipid translocation	GO:0034204	9	0.018	Mouse
digestive tract morphogenesis	GO:0048546	147	0.017
cellular protein complex assembly	GO:0043623	116	0.017
oocyte anterior posterior axis specification	GO:0007314	2	0.017
ribonucleoside metabolic process	GO:0009119	245	0.017
multicellular organismal catabolic process	GO:0044243	7	0.017	Mouse
oocyte axis specification	GO:0007309	2	0.017
negative regulation of phosphate metabolic process	GO:0045936	184	0.017	Mouse
response to decreased oxygen levels	GO:0036293	59	0.017
endodermal cell fate specification	GO:0001714	4	0.017
gonad development	GO:0008406	141	0.017
hexose metabolic process	GO:0019318	98	0.017
positive regulation of endopeptidase activity	GO:0010950	43	0.017	Mouse
cellular response to organonitrogen compound	GO:0071417	145	0.017
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.017
dephosphorylation	GO:0016311	129	0.017
skeletal muscle fiber development	GO:0048741	58	0.017
zymogen activation	GO:0031638	41	0.016	Mouse
regulation of vesicle mediated transport	GO:0060627	139	0.016
regulation of tissue remodeling	GO:0034103	38	0.016	Mouse
cell maturation	GO:0048469	127	0.016
detection of external stimulus	GO:0009581	61	0.016
cellular response to external stimulus	GO:0071496	88	0.016	Mouse
regulation of synaptic plasticity	GO:0048167	87	0.016	Mouse
regulation of tube size	GO:0035150	57	0.016	Mouse
single organism cell adhesion	GO:0098602	156	0.016
carbohydrate derivative catabolic process	GO:1901136	231	0.016
intracellular mrna localization	GO:0008298	4	0.016
digestive tract development	GO:0048565	190	0.016
cell cell junction organization	GO:0045216	72	0.016
neuromuscular process	GO:0050905	99	0.016
spermatid differentiation	GO:0048515	115	0.016
multicellular organismal protein catabolic process	GO:0044254	1	0.016	Mouse
defense response to bacterium	GO:0042742	119	0.015	Mouse
myotube cell development	GO:0014904	60	0.015
stem cell maintenance	GO:0019827	130	0.015
macromolecule methylation	GO:0043414	120	0.015
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.015
positive regulation of immune effector process	GO:0002699	107	0.015	Mouse
divalent inorganic cation transport	GO:0072511	178	0.015	Mouse
amino acid transport	GO:0006865	61	0.015	Mouse
glycerolipid metabolic process	GO:0046486	122	0.015
axon guidance	GO:0007411	141	0.015
cytoplasmic transport	GO:0016482	234	0.015	Mouse
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.015
pore complex assembly	GO:0046931	3	0.015	Mouse
organonitrogen compound catabolic process	GO:1901565	264	0.015
detection of abiotic stimulus	GO:0009582	60	0.015
regulation of cell cycle	GO:0051726	281	0.015
purine nucleotide metabolic process	GO:0006163	302	0.015
positive regulation of cellular component biogenesis	GO:0044089	94	0.015
positive regulation of cell cycle	GO:0045787	92	0.015
muscle fiber development	GO:0048747	76	0.015
response to steroid hormone	GO:0048545	56	0.015
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.015	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.015
glucose homeostasis	GO:0042593	128	0.015
interleukin 1 alpha secretion	GO:0050703	3	0.014	Mouse
urogenital system development	GO:0001655	261	0.014
insulin secretion	GO:0030073	89	0.014
t cell proliferation	GO:0042098	120	0.014	Mouse
defense response to other organism	GO:0098542	197	0.014	Mouse
rho protein signal transduction	GO:0007266	32	0.014
establishment of vesicle localization	GO:0051650	81	0.014	Mouse
cellular response to inorganic substance	GO:0071241	37	0.014
meiotic cell cycle	GO:0051321	122	0.014
mesenchymal cell differentiation	GO:0048762	107	0.014
regulation of neurotransmitter levels	GO:0001505	87	0.014	Mouse
glucose metabolic process	GO:0006006	92	0.014
regulation of cell activation	GO:0050865	289	0.014
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	27	0.014	Mouse
regulation of interleukin 1 beta secretion	GO:0050706	15	0.014	Mouse
organophosphate catabolic process	GO:0046434	232	0.014
regulation of bone remodeling	GO:0046850	28	0.014	Mouse
single organismal cell cell adhesion	GO:0016337	131	0.014
aromatic compound catabolic process	GO:0019439	286	0.014
regulation of cellular catabolic process	GO:0031329	242	0.014
fertilization	GO:0009566	127	0.014
dendritic spine development	GO:0060996	30	0.013
peripheral nervous system development	GO:0007422	53	0.013
acid secretion	GO:0046717	33	0.013	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.013
negative regulation of cellular component organization	GO:0051129	194	0.013
maintenance of location	GO:0051235	89	0.013	Mouse
negative regulation of cell adhesion	GO:0007162	45	0.013
lung development	GO:0030324	164	0.013
regulation of cell migration	GO:0030334	219	0.013
nitric oxide metabolic process	GO:0046209	25	0.013	Mouse
response to organic cyclic compound	GO:0014070	198	0.013
regulation of cytokine secretion	GO:0050707	61	0.013	Mouse
cellularization	GO:0007349	1	0.013
nucleoside triphosphate catabolic process	GO:0009143	205	0.013
vasodilation	GO:0042311	28	0.013	Mouse
adult locomotory behavior	GO:0008344	91	0.013
fat cell differentiation	GO:0045444	160	0.013
nuclear division	GO:0000280	158	0.013
interleukin 1 beta production	GO:0032611	30	0.013	Mouse
female gamete generation	GO:0007292	74	0.013
regulation of peptidase activity	GO:0052547	96	0.013	Mouse
mesoderm development	GO:0007498	100	0.013
cellular response to peptide hormone stimulus	GO:0071375	92	0.013
heterocycle catabolic process	GO:0046700	280	0.013
cellular alcohol metabolic process	GO:0044107	3	0.013
endocrine system development	GO:0035270	98	0.013
neuron projection guidance	GO:0097485	141	0.013
epidermis development	GO:0008544	187	0.013
ameboidal type cell migration	GO:0001667	128	0.013
positive regulation of protein secretion	GO:0050714	52	0.013	Mouse
intrinsic apoptotic signaling pathway	GO:0097193	132	0.013
chromatin organization	GO:0006325	206	0.013
response to radiation	GO:0009314	165	0.013
cellular amide metabolic process	GO:0043603	58	0.012
lipid transport	GO:0006869	98	0.012	Mouse
rna processing	GO:0006396	105	0.012
establishment of synaptic vesicle localization	GO:0097480	57	0.012	Mouse
mrna metabolic process	GO:0016071	84	0.012
protein secretion	GO:0009306	111	0.012	Mouse
microtubule cytoskeleton organization	GO:0000226	157	0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.012
response to purine containing compound	GO:0014074	28	0.012
organic cyclic compound catabolic process	GO:1901361	295	0.012
response to temperature stimulus	GO:0009266	55	0.012	Mouse
regulation of peptide secretion	GO:0002791	77	0.012
positive regulation of protein kinase activity	GO:0045860	144	0.012	Mouse
cellular response to organic cyclic compound	GO:0071407	87	0.012
regulation of leukocyte apoptotic process	GO:2000106	56	0.012	Mouse
establishment or maintenance of cell polarity	GO:0007163	86	0.012
activation of cysteine type endopeptidase activity	GO:0097202	27	0.012	Mouse
male gonad development	GO:0008584	88	0.012
cell junction organization	GO:0034330	77	0.012
heart morphogenesis	GO:0003007	178	0.012
bone remodeling	GO:0046849	53	0.012	Mouse
hair cycle	GO:0042633	90	0.012
regulation of multi organism process	GO:0043900	111	0.012
sulfur compound metabolic process	GO:0006790	100	0.012
regulation of protein transport	GO:0051223	163	0.012	Mouse
posttranscriptional regulation of gene expression	GO:0010608	155	0.012
regulation of smooth muscle contraction	GO:0006940	22	0.011	Mouse
developmental cell growth	GO:0048588	84	0.011
stem cell proliferation	GO:0072089	117	0.011
detection of external biotic stimulus	GO:0098581	9	0.011
regulation of cell growth	GO:0001558	91	0.011
rna interference	GO:0016246	2	0.011
tissue remodeling	GO:0048771	102	0.011	Mouse
sensory perception of chemical stimulus	GO:0007606	51	0.011
myeloid cell differentiation	GO:0030099	233	0.011
cellular response to growth factor stimulus	GO:0071363	197	0.011
epithelial tube morphogenesis	GO:0060562	303	0.011
cellular response to insulin stimulus	GO:0032869	78	0.011
multicellular organismal macromolecule metabolic process	GO:0044259	19	0.011	Mouse
positive regulation of organic acid transport	GO:0032892	11	0.011	Mouse
stem cell differentiation	GO:0048863	268	0.011
regulation of cardioblast differentiation	GO:0051890	3	0.011
nephron development	GO:0072006	109	0.011
regulation of neural retina development	GO:0061074	3	0.011
prostaglandin transport	GO:0015732	7	0.011	Mouse
myelination	GO:0042552	74	0.011
nucleoside catabolic process	GO:0009164	206	0.011
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.011
negative regulation of neuron projection development	GO:0010977	50	0.011
small molecule biosynthetic process	GO:0044283	132	0.011
lipid localization	GO:0010876	126	0.011	Mouse
negative regulation of homeostatic process	GO:0032845	71	0.011	Mouse
regulation of antimicrobial humoral response	GO:0002759	3	0.011
cell substrate adhesion	GO:0031589	130	0.011
positive regulation of protein transport	GO:0051222	93	0.011	Mouse
locomotory behavior	GO:0007626	195	0.011
regulation of organic acid transport	GO:0032890	16	0.011	Mouse
pallium development	GO:0021543	120	0.011
regulation of cellular response to stress	GO:0080135	159	0.011
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.011
purine containing compound metabolic process	GO:0072521	311	0.011
oogenesis	GO:0048477	56	0.011
epithelial tube formation	GO:0072175	130	0.011
anatomical structure homeostasis	GO:0060249	145	0.011	Mouse
regulation of cell projection organization	GO:0031344	206	0.011
skin development	GO:0043588	220	0.011
mrna processing	GO:0006397	63	0.011
hair follicle development	GO:0001942	85	0.011
mapk cascade	GO:0000165	281	0.011	Mouse
organic hydroxy compound metabolic process	GO:1901615	203	0.010
neuron apoptotic process	GO:0051402	142	0.010
morphogenesis of embryonic epithelium	GO:0016331	159	0.010
germ cell development	GO:0007281	185	0.010
response to atp	GO:0033198	8	0.010
nucleoside metabolic process	GO:0009116	246	0.010
regulation of interleukin 1 production	GO:0032652	26	0.010	Mouse
positive regulation of leukocyte apoptotic process	GO:2000108	21	0.010	Mouse
positive regulation of inositol phosphate biosynthetic process	GO:0060732	2	0.010
synapse assembly	GO:0007416	56	0.010
regulation of transmembrane transport	GO:0034762	128	0.010

P2rx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.023
disease of cellular proliferation	DOID:14566	0.016
bone development disease	DOID:0080006	0.015
bone disease	DOID:0080001	0.015
osteochondrodysplasia	DOID:2256	0.015
disease of anatomical entity	DOID:7	0.015
connective tissue disease	DOID:65	0.015
musculoskeletal system disease	DOID:17	0.015
acquired metabolic disease	DOID:0060158	0.014

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