IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Pdhx

pyruvate dehydrogenase complex, component X

(Aliases: Pdx1,E3bp,AI481367)

Ensembl: ENSMUSG00000010914
Entrez: 27402
UniProtKB: Q8BKZ9

Process Predictions
Disease Predictions

Pdhx biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
mitochondrion organization	GO:0007005	134	0.142
heterocycle catabolic process	GO:0046700	280	0.048
acetyl coa biosynthetic process from pyruvate	GO:0006086	3	0.044
cellular amino acid metabolic process	GO:0006520	103	0.043
intracellular protein transport	GO:0006886	204	0.043
sulfur compound metabolic process	GO:0006790	100	0.040
protein localization to organelle	GO:0033365	185	0.035
transmembrane transport	GO:0055085	412	0.033
purine ribonucleoside metabolic process	GO:0046128	241	0.033
organonitrogen compound biosynthetic process	GO:1901566	192	0.032
regulation of apoptotic signaling pathway	GO:2001233	197	0.032
macromolecule catabolic process	GO:0009057	281	0.031
sulfur compound biosynthetic process	GO:0044272	37	0.031
membrane organization	GO:0061024	245	0.031
cellular homeostasis	GO:0019725	240	0.031
protein processing	GO:0016485	163	0.030
cellular ketone metabolic process	GO:0042180	84	0.029
intrinsic apoptotic signaling pathway	GO:0097193	132	0.029
nucleobase containing small molecule metabolic process	GO:0055086	352	0.028
regulation of cellular component biogenesis	GO:0044087	181	0.028
metal ion homeostasis	GO:0055065	189	0.027
cellular amine metabolic process	GO:0044106	44	0.027
regulation of cellular ketone metabolic process	GO:0010565	66	0.026
cation homeostasis	GO:0055080	212	0.026
negative regulation of intracellular signal transduction	GO:1902532	167	0.025
amine metabolic process	GO:0009308	45	0.024
regulation of organelle organization	GO:0033043	289	0.024
purine ribonucleotide metabolic process	GO:0009150	290	0.023
cellular chemical homeostasis	GO:0055082	215	0.023
regulation of cellular amine metabolic process	GO:0033238	20	0.022
coenzyme metabolic process	GO:0006732	52	0.022
cellular metal ion homeostasis	GO:0006875	151	0.022
establishment of protein localization to organelle	GO:0072594	118	0.021
cytoplasmic transport	GO:0016482	234	0.021
cellular lipid metabolic process	GO:0044255	323	0.021
protein targeting	GO:0006605	143	0.021
regulation of lymphocyte activation	GO:0051249	240	0.021
positive regulation of cellular amine metabolic process	GO:0033240	5	0.021
small gtpase mediated signal transduction	GO:0007264	97	0.020
acyl coa biosynthetic process	GO:0071616	7	0.020
regulation of cell activation	GO:0050865	289	0.020
protein processing involved in protein targeting to mitochondrion	GO:0006627	1	0.020
ion transmembrane transport	GO:0034220	361	0.020
cellular response to hormone stimulus	GO:0032870	150	0.020
cofactor metabolic process	GO:0051186	80	0.019
cation transport	GO:0006812	399	0.019
muscle cell differentiation	GO:0042692	261	0.018
cristae formation	GO:0042407	3	0.018
response to organonitrogen compound	GO:0010243	246	0.018
homeostasis of number of cells	GO:0048872	210	0.018
t cell activation	GO:0042110	289	0.018
mitochondrial translation	GO:0032543	4	0.018
apoptotic signaling pathway	GO:0097190	306	0.018
response to organic cyclic compound	GO:0014070	198	0.018
nucleoside phosphate metabolic process	GO:0006753	338	0.018
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.017
mitotic cell cycle	GO:0000278	195	0.017
ribose phosphate metabolic process	GO:0019693	291	0.017
morphogenesis of embryonic epithelium	GO:0016331	159	0.016
cell type specific apoptotic process	GO:0097285	268	0.016
regulation of cellular amino acid metabolic process	GO:0006521	5	0.016
translation	GO:0006412	93	0.016
protein localization to mitochondrion	GO:0070585	15	0.016
peptidyl amino acid modification	GO:0018193	336	0.016
protein catabolic process	GO:0030163	221	0.016
cation transmembrane transport	GO:0098655	266	0.016
organic hydroxy compound metabolic process	GO:1901615	203	0.015
protein targeting to mitochondrion	GO:0006626	6	0.015
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.015
organic cyclic compound catabolic process	GO:1901361	295	0.015
organophosphate biosynthetic process	GO:0090407	122	0.015
iron sulfur cluster assembly	GO:0016226	3	0.015
nuclear transport	GO:0051169	139	0.015
purine containing compound metabolic process	GO:0072521	311	0.015
cellular ion homeostasis	GO:0006873	165	0.015
lymphocyte differentiation	GO:0030098	242	0.015
ribonucleotide metabolic process	GO:0009259	291	0.015
lymphocyte proliferation	GO:0046651	164	0.015
cell adhesion	GO:0007155	329	0.014
skeletal system development	GO:0001501	356	0.014
regulation of cellular catabolic process	GO:0031329	242	0.014
primary neural tube formation	GO:0014020	95	0.014
small molecule biosynthetic process	GO:0044283	132	0.014
protein import	GO:0017038	101	0.014
positive regulation of protein modification process	GO:0031401	299	0.014
transmission of nerve impulse	GO:0019226	76	0.014
cellular response to cytokine stimulus	GO:0071345	189	0.014
synapse organization	GO:0050808	125	0.014
negative regulation of cellular component organization	GO:0051129	194	0.014
nitrogen compound transport	GO:0071705	271	0.014
chromatin organization	GO:0006325	206	0.014
dicarboxylic acid metabolic process	GO:0043648	18	0.014
dephosphorylation	GO:0016311	129	0.014
neuron apoptotic process	GO:0051402	142	0.014
regulation of hydrolase activity	GO:0051336	246	0.014
acetyl coa biosynthetic process	GO:0006085	5	0.014
lipid biosynthetic process	GO:0008610	179	0.013
mitochondrial membrane organization	GO:0007006	26	0.013
connective tissue development	GO:0061448	179	0.013
mitochondrial calcium ion homeostasis	GO:0051560	7	0.013
posttranscriptional regulation of gene expression	GO:0010608	155	0.013
fat cell differentiation	GO:0045444	160	0.013
ribonucleotide catabolic process	GO:0009261	208	0.013
carbohydrate derivative biosynthetic process	GO:1901137	183	0.013
cellular response to organonitrogen compound	GO:0071417	145	0.013
endocytosis	GO:0006897	168	0.013
purine ribonucleotide catabolic process	GO:0009154	208	0.013
regulation of membrane potential	GO:0042391	192	0.013
inorganic cation transmembrane transport	GO:0098662	207	0.013
dna metabolic process	GO:0006259	303	0.013
aromatic compound catabolic process	GO:0019439	286	0.013
immune effector process	GO:0002252	321	0.013
carbohydrate derivative catabolic process	GO:1901136	231	0.012
camera type eye development	GO:0043010	266	0.012
cellular calcium ion homeostasis	GO:0006874	119	0.012
positive regulation of cell development	GO:0010720	237	0.012
cofactor biosynthetic process	GO:0051188	41	0.012
regulation of cellular response to stress	GO:0080135	159	0.012
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.012
striated muscle tissue development	GO:0014706	293	0.012
negative regulation of cellular amine metabolic process	GO:0033239	1	0.012
leukocyte proliferation	GO:0070661	172	0.012
cellular amide metabolic process	GO:0043603	58	0.012
purine nucleoside metabolic process	GO:0042278	241	0.012
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.012
germ cell development	GO:0007281	185	0.012
inorganic ion transmembrane transport	GO:0098660	234	0.012
t cell proliferation	GO:0042098	120	0.012
nucleoside metabolic process	GO:0009116	246	0.012
covalent chromatin modification	GO:0016569	163	0.012
response to inorganic substance	GO:0010035	96	0.012
protein maturation	GO:0051604	176	0.012
regulation of t cell activation	GO:0050863	170	0.012
protein import into nucleus	GO:0006606	95	0.012
purine nucleoside catabolic process	GO:0006152	205	0.012
locomotory behavior	GO:0007626	195	0.011
spermatogenesis	GO:0007283	284	0.011
regulation of protein complex assembly	GO:0043254	83	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.011
positive regulation of organelle organization	GO:0010638	128	0.011
inflammatory response	GO:0006954	244	0.011
oxidation reduction process	GO:0055114	342	0.011
inner mitochondrial membrane organization	GO:0007007	5	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.011
cofactor transport	GO:0051181	4	0.011
leukocyte differentiation	GO:0002521	342	0.011
muscle tissue development	GO:0060537	308	0.011
lymphocyte homeostasis	GO:0002260	64	0.011
mitochondrion degradation	GO:0000422	3	0.011
response to oxidative stress	GO:0006979	123	0.011
regulation of secretion by cell	GO:1903530	249	0.011
glycosyl compound catabolic process	GO:1901658	206	0.011
regulation of anatomical structure size	GO:0090066	178	0.011
mapk cascade	GO:0000165	281	0.011
positive regulation of lymphocyte activation	GO:0051251	140	0.011
action potential	GO:0001508	78	0.011
nucleocytoplasmic transport	GO:0006913	139	0.011
cellular nitrogen compound catabolic process	GO:0044270	280	0.011
divalent inorganic cation transport	GO:0072511	178	0.011
regulation of protein localization	GO:0032880	231	0.011
mitochondrial protein processing	GO:0034982	5	0.011
regulation of cytokine production	GO:0001817	266	0.011
cytokine production	GO:0001816	319	0.011
glutamate biosynthetic process	GO:0006537	2	0.011
t cell differentiation	GO:0030217	174	0.011
canonical wnt signaling pathway	GO:0060070	130	0.010
response to oxygen levels	GO:0070482	62	0.010
wound healing	GO:0042060	157	0.010
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.010
negative regulation of protein metabolic process	GO:0051248	282	0.010
response to molecule of bacterial origin	GO:0002237	143	0.010
negative regulation of cell proliferation	GO:0008285	296	0.010
multicellular organismal signaling	GO:0035637	91	0.010
positive regulation of cell activation	GO:0050867	158	0.010
positive regulation of protein phosphorylation	GO:0001934	242	0.010
male gamete generation	GO:0048232	285	0.010
neural tube development	GO:0021915	160	0.010
glycosyl compound metabolic process	GO:1901657	246	0.010
nucleoside catabolic process	GO:0009164	206	0.010
regulation of proteolysis	GO:0030162	164	0.010

Pdhx disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.020
disease of anatomical entity	DOID:7	0.020
central nervous system disease	DOID:331	0.012
neurodegenerative disease	DOID:1289	0.012

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