IMP: Integrative Multi-species Prediction

Mus musculus

52 known processes

Plau

plasminogen activator, urokinase

(Aliases: uPA,u-PA)

Ensembl: ENSMUSG00000021822
Entrez: 18792
UniProtKB: P06869
UniProtKB: Q0VBA8

Process Predictions
Disease Predictions

Plau biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
branching involved in salivary gland morphogenesis	GO:0060445	26	0.981	Mouse
hepatocyte growth factor receptor signaling pathway	GO:0048012	3	0.951	Mouse
morphogenesis of a branching structure	GO:0001763	203	0.855	Mouse
keratinocyte migration	GO:0051546	3	0.808
mapk cascade	GO:0000165	281	0.752	Mouse
mesenchymal epithelial cell signaling	GO:0060638	9	0.723	Mouse
mononuclear cell migration	GO:0071674	8	0.664	Mouse
regulation of protein serine threonine kinase activity	GO:0071900	157	0.641	Mouse
muscle cell differentiation	GO:0042692	261	0.628	Mouse
hemostasis	GO:0007599	78	0.614
salivary gland development	GO:0007431	37	0.608	Mouse
leukocyte migration	GO:0050900	124	0.605	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.603
blood vessel morphogenesis	GO:0048514	285	0.602	Rat
cation homeostasis	GO:0055080	212	0.570
cytokine production	GO:0001816	319	0.557
negative regulation of response to wounding	GO:1903035	77	0.553
response to molecule of bacterial origin	GO:0002237	143	0.525	Rat
regulation of apoptotic signaling pathway	GO:2001233	197	0.521	Mouse
platelet derived growth factor receptor signaling pathway	GO:0048008	32	0.519	Mouse
chemotaxis	GO:0006935	247	0.507
calcium ion transport	GO:0006816	159	0.501
regulation of system process	GO:0044057	200	0.486
response to lipopolysaccharide	GO:0032496	128	0.476	Rat
cellular response to lipid	GO:0071396	145	0.474	Rat
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.470	Mouse
placenta blood vessel development	GO:0060674	31	0.456	Mouse
cellular homeostasis	GO:0019725	240	0.452	Mouse Rat
placenta development	GO:0001890	140	0.447	Mouse
positive regulation of defense response	GO:0031349	124	0.445
wound healing	GO:0042060	157	0.444
extrinsic apoptotic signaling pathway	GO:0097191	126	0.443	Mouse
positive regulation of cell death	GO:0010942	224	0.442
apoptotic signaling pathway	GO:0097190	306	0.410	Mouse
regulation of protein transport	GO:0051223	163	0.407
cell differentiation involved in embryonic placenta development	GO:0060706	26	0.406	Mouse
regulation of organ morphogenesis	GO:2000027	144	0.401	Mouse Rat
cation transport	GO:0006812	399	0.390
synaptic transmission	GO:0007268	329	0.388
response to decreased oxygen levels	GO:0036293	59	0.387
regulation of branching involved in salivary gland morphogenesis	GO:0060693	11	0.382	Mouse
positive regulation of inflammatory response	GO:0050729	47	0.375
activation of mapk activity	GO:0000187	59	0.373	Mouse
cellular response to biotic stimulus	GO:0071216	92	0.368	Rat
regulation of mapk cascade	GO:0043408	248	0.366	Mouse
negative regulation of protein processing	GO:0010955	79	0.363
regulation of transferase activity	GO:0051338	263	0.359	Mouse
regulation of defense response	GO:0031347	233	0.358
positive regulation of transferase activity	GO:0051347	167	0.353	Mouse
regulation of response to wounding	GO:1903034	189	0.351
exocrine system development	GO:0035272	45	0.351	Mouse
salivary gland morphogenesis	GO:0007435	33	0.347	Mouse
cellular amine metabolic process	GO:0044106	44	0.341
myoblast proliferation	GO:0051450	11	0.334	Mouse
positive regulation of vasoconstriction	GO:0045907	4	0.334
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.332	Mouse
regulation of inflammatory response	GO:0050727	147	0.327
myoblast differentiation	GO:0045445	52	0.327	Mouse
response to organic cyclic compound	GO:0014070	198	0.320	Rat
regulation of protein kinase activity	GO:0045859	232	0.318	Mouse
regulation of multi organism process	GO:0043900	111	0.316	Rat
morphogenesis of a branching epithelium	GO:0061138	193	0.316	Mouse
coagulation	GO:0050817	78	0.315
divalent inorganic cation homeostasis	GO:0072507	138	0.313
regulation of cytokine production	GO:0001817	266	0.306
divalent inorganic cation transport	GO:0072511	178	0.303
ameboidal type cell migration	GO:0001667	128	0.302
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.300
positive regulation of mapk cascade	GO:0043410	170	0.295	Mouse
regulation of ion transport	GO:0043269	215	0.293
negative regulation of cell proliferation	GO:0008285	296	0.284
blood coagulation	GO:0007596	76	0.281
extracellular matrix organization	GO:0030198	147	0.277
positive regulation of kinase activity	GO:0033674	155	0.265	Mouse
regulation of fat cell differentiation	GO:0045598	81	0.264
regulation of ovulation	GO:0060278	3	0.262	Rat
response to oxygen levels	GO:0070482	62	0.254
cytokine secretion	GO:0050663	72	0.250
regulation of map kinase activity	GO:0043405	120	0.249	Mouse
negative regulation of blood pressure	GO:0045776	22	0.248
inflammatory response	GO:0006954	244	0.248
labyrinthine layer development	GO:0060711	49	0.247	Mouse
myeloid cell differentiation	GO:0030099	233	0.241
smooth muscle contraction	GO:0006939	44	0.238
angiogenesis	GO:0001525	201	0.237	Rat
ion transmembrane transport	GO:0034220	361	0.234
reactive oxygen species biosynthetic process	GO:1903409	8	0.232
regulation of cell activation	GO:0050865	289	0.229
divalent metal ion transport	GO:0070838	172	0.226
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.224
positive regulation of cytokine production	GO:0001819	174	0.222
regulation of body fluid levels	GO:0050878	162	0.220
gland development	GO:0048732	330	0.219	Mouse Rat
multi multicellular organism process	GO:0044706	109	0.215	Mouse Rat
cellular response to lipopolysaccharide	GO:0071222	77	0.214	Rat
defense response to bacterium	GO:0042742	119	0.211
anatomical structure homeostasis	GO:0060249	145	0.208	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.206
cellular amino acid metabolic process	GO:0006520	103	0.205
immune response activating signal transduction	GO:0002757	116	0.204
negative regulation of secretion	GO:0051048	61	0.203
positive regulation of ion transport	GO:0043270	65	0.203
positive regulation of angiogenesis	GO:0045766	46	0.202
negative regulation of cellular protein metabolic process	GO:0032269	247	0.202
cellular calcium ion homeostasis	GO:0006874	119	0.202
response to organophosphorus	GO:0046683	22	0.202
fibrinolysis	GO:0042730	3	0.201
cellular ion homeostasis	GO:0006873	165	0.201
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.199
membrane organization	GO:0061024	245	0.198
antibacterial peptide secretion	GO:0002779	1	0.194
negative regulation of cytokine production	GO:0001818	84	0.193
regulation of secretion	GO:0051046	274	0.193
cellular response to molecule of bacterial origin	GO:0071219	83	0.191	Rat
antibacterial peptide biosynthetic process	GO:0002780	2	0.190
amine metabolic process	GO:0009308	45	0.190
regulation of hemostasis	GO:1900046	28	0.189
skeletal system morphogenesis	GO:0048705	203	0.187
negative regulation of proteolysis	GO:0045861	74	0.184
response to organonitrogen compound	GO:0010243	246	0.184	Rat
transmembrane transport	GO:0055085	412	0.182
calcium ion transport into cytosol	GO:0060402	48	0.182
reactive oxygen species metabolic process	GO:0072593	84	0.181	Rat
positive regulation of protein kinase activity	GO:0045860	144	0.180	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.178
regulation of morphogenesis of a branching structure	GO:0060688	53	0.175	Mouse
regulation of protein localization	GO:0032880	231	0.174
defense response to other organism	GO:0098542	197	0.174
cell adhesion	GO:0007155	329	0.168	Human
negative regulation of coagulation	GO:0050819	11	0.165
t cell activation	GO:0042110	289	0.163
kidney development	GO:0001822	213	0.162
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.160
calcium ion homeostasis	GO:0055074	127	0.159
negative regulation of protein modification process	GO:0031400	163	0.159
lipid biosynthetic process	GO:0008610	179	0.155
leukocyte mediated immunity	GO:0002443	174	0.154
protein catabolic process	GO:0030163	221	0.152
peptide metabolic process	GO:0006518	46	0.149
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902042	11	0.147	Mouse
cellular response to cytokine stimulus	GO:0071345	189	0.147
vascular endothelial growth factor production	GO:0010573	13	0.147
regulation of blood pressure	GO:0008217	93	0.144
response to peptide hormone	GO:0043434	127	0.144
immune response regulating signaling pathway	GO:0002764	125	0.144
regulation of chemotaxis	GO:0050920	53	0.142
muscle contraction	GO:0006936	101	0.139
liver development	GO:0001889	66	0.138	Mouse Rat
positive regulation of map kinase activity	GO:0043406	84	0.138	Mouse
regulation of cellular response to stress	GO:0080135	159	0.138
granulocyte migration	GO:0097530	43	0.138
muscle cell cellular homeostasis	GO:0046716	12	0.137	Mouse
regulation of vasculature development	GO:1901342	88	0.135
regulation of cellular amine metabolic process	GO:0033238	20	0.134
nitric oxide metabolic process	GO:0046209	25	0.134
protein secretion	GO:0009306	111	0.133
response to catecholamine	GO:0071869	4	0.132
response to hypoxia	GO:0001666	58	0.129
nucleobase containing small molecule metabolic process	GO:0055086	352	0.129
response to purine containing compound	GO:0014074	28	0.127
muscle system process	GO:0003012	141	0.127
regulation of synaptic plasticity	GO:0048167	87	0.126
immune effector process	GO:0002252	321	0.126
positive regulation of protein phosphorylation	GO:0001934	242	0.125	Mouse
fat cell differentiation	GO:0045444	160	0.124
positive regulation of protein modification process	GO:0031401	299	0.122	Mouse
multicellular organismal homeostasis	GO:0048871	164	0.122
myotube differentiation	GO:0014902	105	0.122
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.121	Mouse
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.121
blood circulation	GO:0008015	195	0.120
interleukin 10 secretion	GO:0072608	4	0.120
positive regulation of response to wounding	GO:1903036	66	0.120
tumor necrosis factor production	GO:0032640	50	0.120
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.118
defense response to gram positive bacterium	GO:0050830	50	0.117
cellular macromolecule catabolic process	GO:0044265	206	0.117
g protein coupled receptor signaling pathway	GO:0007186	243	0.117
regulation of kinase activity	GO:0043549	249	0.116	Mouse
metal ion homeostasis	GO:0055065	189	0.116
regulation of transmembrane transport	GO:0034762	128	0.116
multicellular organism growth	GO:0035264	161	0.115
antimicrobial peptide biosynthetic process	GO:0002777	2	0.114
regulation of innate immune response	GO:0045088	91	0.114
regulation of leukocyte proliferation	GO:0070663	121	0.112
regulation of branching involved in salivary gland morphogenesis by mesenchymal epithelial signaling	GO:0060665	5	0.111	Mouse
cellular ketone metabolic process	GO:0042180	84	0.111
regulation of protein processing	GO:0070613	96	0.111
regulation of metal ion transport	GO:0010959	106	0.110
negative regulation of immune system process	GO:0002683	209	0.106
positive regulation of synaptic plasticity	GO:0031915	4	0.104
antimicrobial peptide production	GO:0002775	2	0.104
regulation of tube size	GO:0035150	57	0.102
purine containing compound catabolic process	GO:0072523	213	0.102
macromolecule catabolic process	GO:0009057	281	0.101
aromatic compound catabolic process	GO:0019439	286	0.100
epithelium migration	GO:0090132	63	0.100
extracellular structure organization	GO:0043062	148	0.100
cellular response to hormone stimulus	GO:0032870	150	0.100
ribonucleotide metabolic process	GO:0009259	291	0.100
protein processing	GO:0016485	163	0.099
tissue remodeling	GO:0048771	102	0.098
positive regulation of nervous system development	GO:0051962	221	0.097
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.096
protein maturation	GO:0051604	176	0.096
prostaglandin metabolic process	GO:0006693	11	0.095
cellular amide metabolic process	GO:0043603	58	0.094
regulation of anatomical structure size	GO:0090066	178	0.092
regulation of macrophage chemotaxis	GO:0010758	8	0.091
digestive tract development	GO:0048565	190	0.091
antibacterial peptide production	GO:0002778	2	0.091
regulation of protein kinase b signaling	GO:0051896	56	0.091
embryonic placenta development	GO:0001892	98	0.091	Mouse
reactive nitrogen species metabolic process	GO:2001057	0	0.090
response to steroid hormone	GO:0048545	56	0.090
regulation of cytokine secretion	GO:0050707	61	0.090
biomineral tissue development	GO:0031214	64	0.090
regulation of protein secretion	GO:0050708	82	0.089
organic anion transport	GO:0015711	137	0.088
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.088
regulation of ion transmembrane transport	GO:0034765	119	0.087
small molecule biosynthetic process	GO:0044283	132	0.087
positive regulation of acute inflammatory response	GO:0002675	16	0.087
second messenger mediated signaling	GO:0019932	73	0.086
negative regulation of molecular function	GO:0044092	258	0.085
regulation of interleukin 6 production	GO:0032675	55	0.084
fibroblast growth factor production	GO:0090269	4	0.084
negative regulation of wound healing	GO:0061045	14	0.084
nitrogen compound transport	GO:0071705	271	0.084
regulation of muscle system process	GO:0090257	80	0.084
cellular protein catabolic process	GO:0044257	155	0.083
regulation of cell migration	GO:0030334	219	0.083	Human Rat
positive regulation of monocyte chemotaxis	GO:0090026	2	0.083
vasoconstriction	GO:0042310	27	0.082
production of molecular mediator of immune response	GO:0002440	103	0.082
positive regulation of fat cell differentiation	GO:0045600	32	0.082
connective tissue development	GO:0061448	179	0.082
response to light stimulus	GO:0009416	135	0.081
cellular response to growth factor stimulus	GO:0071363	197	0.081	Rat
response to radiation	GO:0009314	165	0.081
digestion	GO:0007586	40	0.081
regulation of proteolysis	GO:0030162	164	0.080
anion transport	GO:0006820	177	0.080
regulation of blood circulation	GO:1903522	93	0.079
developmental growth involved in morphogenesis	GO:0060560	138	0.079
negative regulation of cell motility	GO:2000146	61	0.079
regulation of cell motility	GO:2000145	236	0.078	Human Rat
stem cell differentiation	GO:0048863	268	0.078
organic acid transport	GO:0015849	101	0.077
negative regulation of fat cell differentiation	GO:0045599	36	0.076
positive regulation of apoptotic process	GO:0043065	217	0.075
regulation of lymphocyte proliferation	GO:0050670	117	0.075
positive regulation of innate immune response	GO:0045089	80	0.073
cell chemotaxis	GO:0060326	81	0.073
regulation of cell adhesion	GO:0030155	154	0.072	Human
multicellular organismal signaling	GO:0035637	91	0.072
digestive system development	GO:0055123	200	0.071
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.071
organic hydroxy compound transport	GO:0015850	93	0.070
cellular response to organic cyclic compound	GO:0071407	87	0.070	Rat
cellular response to glucocorticoid stimulus	GO:0071385	13	0.070
positive regulation of cellular amine metabolic process	GO:0033240	5	0.070
cytoplasmic transport	GO:0016482	234	0.070
protein modification by small protein conjugation or removal	GO:0070647	207	0.070
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.070
branching morphogenesis of an epithelial tube	GO:0048754	159	0.070
tissue regeneration	GO:0042246	22	0.070	Mouse Rat
ovulation	GO:0030728	15	0.069	Rat
i kappab kinase nf kappab signaling	GO:0007249	85	0.069
renal system development	GO:0072001	225	0.069
circulatory system process	GO:0003013	197	0.069
axonogenesis	GO:0007409	274	0.069
negative regulation of protein metabolic process	GO:0051248	282	0.069
regulation of interleukin 12 production	GO:0032655	30	0.067
positive regulation of proteolysis	GO:0045862	85	0.067
negative regulation of cellular amine metabolic process	GO:0033239	1	0.067
regulation of protein maturation	GO:1903317	96	0.067
interspecies interaction between organisms	GO:0044419	83	0.067
multicellular organismal metabolic process	GO:0044236	28	0.067
glycosyl compound metabolic process	GO:1901657	246	0.067
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.067	Mouse
alcohol metabolic process	GO:0006066	116	0.066
cytosolic calcium ion transport	GO:0060401	48	0.066
nucleoside metabolic process	GO:0009116	246	0.066
regulation of vascular endothelial growth factor production	GO:0010574	13	0.065
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.065
peptidyl amino acid modification	GO:0018193	336	0.065
wnt signaling pathway	GO:0016055	188	0.065
oligodendrocyte differentiation	GO:0048709	53	0.065
muscle cell development	GO:0055001	133	0.065
lipid transport	GO:0006869	98	0.065
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	54	0.064
regulation of peptidase activity	GO:0052547	96	0.063
t cell extravasation	GO:0072683	4	0.063
protein kinase b signaling	GO:0043491	74	0.063
negative regulation of protein maturation	GO:1903318	79	0.063
carbohydrate derivative biosynthetic process	GO:1901137	183	0.062
respiratory system development	GO:0060541	190	0.062
epithelial cell development	GO:0002064	159	0.062
modification dependent protein catabolic process	GO:0019941	133	0.062
purinergic nucleotide receptor signaling pathway	GO:0035590	3	0.062
negative regulation of secretion by cell	GO:1903531	54	0.062
lymphocyte proliferation	GO:0046651	164	0.062
cellular metal ion homeostasis	GO:0006875	151	0.062
plasma membrane organization	GO:0007009	90	0.061
regulation of stress activated mapk cascade	GO:0032872	69	0.061
protein oligomerization	GO:0051259	67	0.061
appendage development	GO:0048736	166	0.061
ubiquitin dependent protein catabolic process	GO:0006511	129	0.061
regulation of neuron differentiation	GO:0045664	281	0.060
negative regulation of muscle contraction	GO:0045932	12	0.060
positive regulation vascular endothelial growth factor production	GO:0010575	10	0.060
endocytosis	GO:0006897	168	0.060
positive regulation of cytokine secretion	GO:0050715	41	0.060
regulation of epithelial cell proliferation	GO:0050678	141	0.059	Rat
peptidyl tyrosine modification	GO:0018212	145	0.059
amide transport	GO:0042886	138	0.059
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.059
cartilage development	GO:0051216	140	0.059
ribonucleotide catabolic process	GO:0009261	208	0.058
interleukin 6 production	GO:0032635	58	0.058
sequestering of metal ion	GO:0051238	19	0.057
neuron neuron synaptic transmission	GO:0007270	69	0.057
endochondral bone morphogenesis	GO:0060350	50	0.056
negative regulation of defense response	GO:0031348	77	0.056
negative regulation of phosphorus metabolic process	GO:0010563	184	0.056
organonitrogen compound biosynthetic process	GO:1901566	192	0.056
regulation of cellular catabolic process	GO:0031329	242	0.056
transepithelial chloride transport	GO:0030321	4	0.055
regulation of tumor necrosis factor production	GO:0032680	49	0.055
response to dexamethasone	GO:0071548	8	0.055
myeloid leukocyte migration	GO:0097529	57	0.055
activation of immune response	GO:0002253	138	0.055
regulation of coagulation	GO:0050818	31	0.054
response to tumor necrosis factor	GO:0034612	26	0.054
interleukin 12 production	GO:0032615	32	0.054
regulation of angiogenesis	GO:0045765	81	0.054
purine ribonucleoside metabolic process	GO:0046128	241	0.054
development of primary female sexual characteristics	GO:0046545	73	0.053
regulation of neurotransmitter levels	GO:0001505	87	0.053
glial cell differentiation	GO:0010001	131	0.053
positive regulation of cell motility	GO:2000147	116	0.052	Rat
regulation of hormone levels	GO:0010817	211	0.052
nucleotide catabolic process	GO:0009166	217	0.052
response to peptidoglycan	GO:0032494	9	0.052
leukocyte differentiation	GO:0002521	342	0.051
positive regulation of cell migration	GO:0030335	109	0.051	Rat
regulation of secretion by cell	GO:1903530	249	0.051
positive regulation of homeostatic process	GO:0032846	64	0.050
regulation of lymphocyte activation	GO:0051249	240	0.050
endomembrane system organization	GO:0010256	147	0.050
regulation of muscle contraction	GO:0006937	49	0.049
heterocycle catabolic process	GO:0046700	280	0.049
interleukin 5 secretion	GO:0072603	2	0.049
peptidyl tyrosine phosphorylation	GO:0018108	143	0.049
trabecula formation	GO:0060343	24	0.049
long term synaptic potentiation	GO:0060291	25	0.049
organic hydroxy compound biosynthetic process	GO:1901617	77	0.049
regulation of adaptive immune response	GO:0002819	90	0.049
regulation of wnt signaling pathway	GO:0030111	123	0.049
negative regulation of macrophage apoptotic process	GO:2000110	3	0.049
response to inorganic substance	GO:0010035	96	0.048
neuron projection guidance	GO:0097485	141	0.048
positive regulation of cell activation	GO:0050867	158	0.048
cellular response to ketone	GO:1901655	12	0.048
bone morphogenesis	GO:0060349	78	0.048
hair cycle phase	GO:0044851	16	0.048
cellular response to external stimulus	GO:0071496	88	0.047
regulation of interleukin 13 secretion	GO:2000665	2	0.047
regulation of blood vessel size	GO:0050880	56	0.047
cytokine mediated signaling pathway	GO:0019221	115	0.047
regulation of reproductive process	GO:2000241	66	0.047	Rat
regulation of t cell proliferation	GO:0042129	92	0.047
columnar cuboidal epithelial cell maturation	GO:0002069	4	0.047
positive regulation of blood circulation	GO:1903524	22	0.047
intracellular protein transport	GO:0006886	204	0.047
interleukin 13 secretion	GO:0072611	2	0.047
ceramide metabolic process	GO:0006672	31	0.047
transmission of nerve impulse	GO:0019226	76	0.047
striated muscle cell development	GO:0055002	125	0.046
macrophage chemotaxis	GO:0048246	14	0.046
regulation of vasoconstriction	GO:0019229	14	0.046
regulation of homeostatic process	GO:0032844	182	0.046
dna metabolic process	GO:0006259	303	0.046
leukocyte activation involved in immune response	GO:0002366	126	0.046
regulation of cell projection organization	GO:0031344	206	0.046
epithelial cell proliferation	GO:0050673	174	0.046	Rat
positive regulation of wnt signaling pathway	GO:0030177	45	0.046
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.046
cation transmembrane transport	GO:0098655	266	0.046
regulation of cellular ketone metabolic process	GO:0010565	66	0.045
positive regulation of cell development	GO:0010720	237	0.044
response to vitamin d	GO:0033280	3	0.044
protein ubiquitination	GO:0016567	171	0.044
regulation of blood coagulation	GO:0030193	28	0.044
eosinophil degranulation	GO:0043308	1	0.044
regulation of transporter activity	GO:0032409	57	0.044
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	34	0.044	Mouse
cellular response to organonitrogen compound	GO:0071417	145	0.044	Rat
adenylate cyclase activating g protein coupled receptor signaling pathway	GO:0007189	30	0.043
trabecula morphogenesis	GO:0061383	40	0.043
epithelial tube morphogenesis	GO:0060562	303	0.043
response to camp	GO:0051591	14	0.043
nephron morphogenesis	GO:0072028	69	0.043
forebrain development	GO:0030900	302	0.043
positive regulation of protein transport	GO:0051222	93	0.043
bone trabecula morphogenesis	GO:0061430	12	0.043
regulation of monocyte extravasation	GO:2000437	2	0.043
purine nucleotide metabolic process	GO:0006163	302	0.042
regulation of wound healing	GO:0061041	40	0.042
cardiac muscle tissue development	GO:0048738	130	0.042
positive regulation of glial cell proliferation	GO:0060252	4	0.041
positive regulation of interleukin 12 production	GO:0032735	21	0.041
response to amine	GO:0014075	16	0.041
negative regulation of ion transport	GO:0043271	28	0.041
regulation of receptor binding	GO:1900120	4	0.041
regulation of cytokine production involved in immune response	GO:0002718	26	0.040
eosinophil activation involved in immune response	GO:0002278	1	0.040
ribonucleoside metabolic process	GO:0009119	245	0.040
positive regulation of coagulation	GO:0050820	13	0.040
striated muscle tissue development	GO:0014706	293	0.040
muscle tissue development	GO:0060537	308	0.040
leukocyte chemotaxis	GO:0030595	69	0.039
urogenital system development	GO:0001655	261	0.039
positive regulation of immunological synapse formation	GO:2000522	1	0.039
negative regulation of inflammatory response	GO:0050728	61	0.039
interleukin 1 beta production	GO:0032611	30	0.039
nucleoside phosphate metabolic process	GO:0006753	338	0.039
modification dependent macromolecule catabolic process	GO:0043632	133	0.039
regulation of steroid biosynthetic process	GO:0050810	26	0.039
skeletal system development	GO:0001501	356	0.038
regulation of alpha beta t cell activation	GO:0046634	53	0.038
proteasomal protein catabolic process	GO:0010498	98	0.038
sensory perception of pain	GO:0019233	47	0.038
labyrinthine layer blood vessel development	GO:0060716	21	0.038	Mouse
regulation of g protein coupled receptor protein signaling pathway	GO:0008277	37	0.038
cytokine metabolic process	GO:0042107	71	0.038
regulation of tissue remodeling	GO:0034103	38	0.038
regulation of systemic arterial blood pressure	GO:0003073	61	0.037
negative regulation of phosphorylation	GO:0042326	166	0.037
nucleotide metabolic process	GO:0009117	332	0.037
amino acid transmembrane transport	GO:0003333	37	0.037
positive regulation of leukocyte proliferation	GO:0070665	73	0.037
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.037
organelle localization	GO:0051640	179	0.037
lung development	GO:0030324	164	0.037
negative regulation of cell adhesion	GO:0007162	45	0.037
carboxylic acid transport	GO:0046942	100	0.037
regulation of intracellular transport	GO:0032386	159	0.037
sensory perception	GO:0007600	245	0.037
jnk cascade	GO:0007254	72	0.036
metanephros development	GO:0001656	79	0.036
nuclear transport	GO:0051169	139	0.036
negative regulation of hemostasis	GO:1900047	11	0.036
regulation of cellular component biogenesis	GO:0044087	181	0.036
serotonin transport	GO:0006837	11	0.036
response to growth factor	GO:0070848	198	0.036	Rat
gliogenesis	GO:0042063	141	0.036
positive regulation of muscle contraction	GO:0045933	10	0.036
positive regulation of chemotaxis	GO:0050921	38	0.035
bone development	GO:0060348	120	0.035
cellular response to steroid hormone stimulus	GO:0071383	33	0.035
regulation of oxidoreductase activity	GO:0051341	15	0.035
purine ribonucleotide metabolic process	GO:0009150	290	0.035
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.035
regulation of lipid biosynthetic process	GO:0046890	54	0.035
regulation of immune complex clearance by monocytes and macrophages	GO:0090264	2	0.034
superoxide metabolic process	GO:0006801	27	0.034
regulation of gliogenesis	GO:0014013	50	0.034
protein targeting	GO:0006605	143	0.034
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.034
interaction with host	GO:0051701	22	0.034
negative regulation of phosphate metabolic process	GO:0045936	184	0.034
protein modification by small protein conjugation	GO:0032446	187	0.034
eye photoreceptor cell differentiation	GO:0001754	41	0.034
positive regulation of lymphocyte proliferation	GO:0050671	70	0.034
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.033
defense response to gram negative bacterium	GO:0050829	28	0.033
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.033
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.033	Mouse
synaptic transmission glutamatergic	GO:0035249	36	0.033
regulation of calcium ion transport	GO:0051924	69	0.033
organic acid biosynthetic process	GO:0016053	86	0.033
response to corticosteroid	GO:0031960	20	0.033
response to alcohol	GO:0097305	48	0.033
multicellular organismal catabolic process	GO:0044243	7	0.033
epithelial cell migration	GO:0010631	63	0.032
alpha amino acid catabolic process	GO:1901606	18	0.032
single organism nuclear import	GO:1902593	95	0.032
positive regulation of brown fat cell differentiation	GO:0090336	4	0.032
oxidation reduction process	GO:0055114	342	0.032
fatty acid derivative biosynthetic process	GO:1901570	15	0.032
phospholipase c activating g protein coupled receptor signaling pathway	GO:0007200	26	0.032
vascular process in circulatory system	GO:0003018	62	0.032
positive regulation of lipid transport	GO:0032370	22	0.032
modification by symbiont of host morphology or physiology	GO:0044003	4	0.032
regulation of organelle organization	GO:0033043	289	0.032

Plau disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of metabolism	DOID:0014667	0	0.059
	inherited metabolic disorder	DOID:655	0	0.032

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