IMP: Integrative Multi-species Prediction

Mus musculus

48 known processes

Prdx3

peroxiredoxin 3

(Aliases: D0Tohi1,Aop1,Prx3,Mer5,Ef2l,SP22,TDXM,AW822249)

Entrez: 11757
Ensembl: ENSMUSG00000024997
UniProtKB: P20108

Process Predictions
Disease Predictions

Prdx3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
energy derivation by oxidation of organic compounds	GO:0015980	77	0.305
oxidation reduction process	GO:0055114	342	0.259	Human Mouse Fly
transmembrane transport	GO:0055085	412	0.199
cellular respiration	GO:0045333	38	0.134
iron sulfur cluster assembly	GO:0016226	3	0.122
water soluble vitamin biosynthetic process	GO:0042364	3	0.105
mitochondrial transport	GO:0006839	36	0.094
nucleobase containing small molecule metabolic process	GO:0055086	352	0.083
organonitrogen compound biosynthetic process	GO:1901566	192	0.078
ion transmembrane transport	GO:0034220	361	0.077
generation of precursor metabolites and energy	GO:0006091	103	0.077
purine ribonucleotide metabolic process	GO:0009150	290	0.063
purine ribonucleoside metabolic process	GO:0046128	241	0.061
glycosyl compound metabolic process	GO:1901657	246	0.057
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.049
cofactor metabolic process	GO:0051186	80	0.049
mitochondrion organization	GO:0007005	134	0.048	Human
sulfur compound metabolic process	GO:0006790	100	0.047
atp metabolic process	GO:0046034	75	0.046
cellular amino acid metabolic process	GO:0006520	103	0.046	Mouse
metal ion homeostasis	GO:0055065	189	0.044
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.044
regulation of membrane potential	GO:0042391	192	0.041	Human
cellular ketone metabolic process	GO:0042180	84	0.041
citrate metabolic process	GO:0006101	3	0.038
ribonucleotide metabolic process	GO:0009259	291	0.038
protein targeting	GO:0006605	143	0.035	Mouse
nucleotide metabolic process	GO:0009117	332	0.035
acetyl coa biosynthetic process from pyruvate	GO:0006086	3	0.035
nucleoside triphosphate metabolic process	GO:0009141	230	0.034
sulfur compound biosynthetic process	GO:0044272	37	0.034
nitrogen compound transport	GO:0071705	271	0.033	Mouse
intracellular protein transport	GO:0006886	204	0.033	Mouse
amine metabolic process	GO:0009308	45	0.032
pyruvate transport	GO:0006848	2	0.031
reactive oxygen species metabolic process	GO:0072593	84	0.031	Human Mouse Fly
monocarboxylic acid metabolic process	GO:0032787	191	0.030	Mouse
cellular amine metabolic process	GO:0044106	44	0.030
cation transmembrane transport	GO:0098655	266	0.030
nadh metabolic process	GO:0006734	1	0.029
ribose phosphate metabolic process	GO:0019693	291	0.028
purine containing compound metabolic process	GO:0072521	311	0.028
cytoplasmic transport	GO:0016482	234	0.028	Mouse
phagocytosis	GO:0006909	66	0.027	Fly
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.027
male gamete generation	GO:0048232	285	0.026	Mouse
cation transport	GO:0006812	399	0.026
regulation of cellular amino acid metabolic process	GO:0006521	5	0.025
response to oxygen levels	GO:0070482	62	0.025
water soluble vitamin metabolic process	GO:0006767	10	0.025
cellular ion homeostasis	GO:0006873	165	0.025
negative regulation of cellular component organization	GO:0051129	194	0.025
cation homeostasis	GO:0055080	212	0.025
cellular homeostasis	GO:0019725	240	0.024	Mouse Fly
anion transmembrane transport	GO:0098656	71	0.023
purine nucleotide metabolic process	GO:0006163	302	0.023
small molecule biosynthetic process	GO:0044283	132	0.023
defecation	GO:0030421	1	0.023
positive regulation of cell death	GO:0010942	224	0.023
spermatogenesis	GO:0007283	284	0.022	Mouse
coenzyme metabolic process	GO:0006732	52	0.022
ossification	GO:0001503	216	0.022
cellular metal ion homeostasis	GO:0006875	151	0.022
negative regulation of cell proliferation	GO:0008285	296	0.021	Mouse
regulation of secretion by cell	GO:1903530	249	0.021
divalent inorganic cation transport	GO:0072511	178	0.021
nucleoside metabolic process	GO:0009116	246	0.021
nucleoside phosphate metabolic process	GO:0006753	338	0.021
sequestering of calcium ion	GO:0051208	18	0.020
heart morphogenesis	GO:0003007	178	0.020
protein import	GO:0017038	101	0.020	Mouse
gland development	GO:0048732	330	0.020	Mouse
metallo sulfur cluster assembly	GO:0031163	3	0.020
inorganic cation transmembrane transport	GO:0098662	207	0.019
ribonucleotide biosynthetic process	GO:0009260	59	0.019
myeloid cell differentiation	GO:0030099	233	0.018
anion transport	GO:0006820	177	0.018
inorganic ion transmembrane transport	GO:0098660	234	0.018
positive regulation of cellular amine metabolic process	GO:0033240	5	0.018
regulation of cellular ketone metabolic process	GO:0010565	66	0.018
purine nucleoside metabolic process	GO:0042278	241	0.017
intrinsic apoptotic signaling pathway	GO:0097193	132	0.017
cell type specific apoptotic process	GO:0097285	268	0.017	Rat
regulation of cytoplasmic transport	GO:1903649	112	0.017	Mouse
regulation of secretion	GO:0051046	274	0.017
divalent inorganic cation homeostasis	GO:0072507	138	0.017
regulation of cellular amine metabolic process	GO:0033238	20	0.017
response to hypoxia	GO:0001666	58	0.017
cellular chemical homeostasis	GO:0055082	215	0.017
protein localization to organelle	GO:0033365	185	0.017	Mouse
negative regulation of phosphate metabolic process	GO:0045936	184	0.017	Human
regulation of hormone levels	GO:0010817	211	0.016
coenzyme biosynthetic process	GO:0009108	23	0.016
glycerol ether metabolic process	GO:0006662	2	0.016
nucleoside monophosphate metabolic process	GO:0009123	85	0.016
organic acid biosynthetic process	GO:0016053	86	0.016
action potential	GO:0001508	78	0.015
negative regulation of organelle organization	GO:0010639	90	0.015
copii coated vesicle budding	GO:0090114	2	0.015
divalent metal ion transport	GO:0070838	172	0.015
carbohydrate derivative biosynthetic process	GO:1901137	183	0.015
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.015
response to organonitrogen compound	GO:0010243	246	0.015
regulation of protein complex assembly	GO:0043254	83	0.015
macromolecule catabolic process	GO:0009057	281	0.014
regulation of organelle organization	GO:0033043	289	0.014
regulation of ion transport	GO:0043269	215	0.014
regulation of apoptotic signaling pathway	GO:2001233	197	0.014	Mouse
skeletal system development	GO:0001501	356	0.014
regulation of cellular component biogenesis	GO:0044087	181	0.014
succinyl coa metabolic process	GO:0006104	1	0.014
organic hydroxy compound transport	GO:0015850	93	0.014
neural tube formation	GO:0001841	108	0.014
maintenance of location	GO:0051235	89	0.014
positive regulation of programmed cell death	GO:0043068	218	0.014
membrane organization	GO:0061024	245	0.014
protein maturation	GO:0051604	176	0.014	Human Mouse
lipid catabolic process	GO:0016042	69	0.014
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.013
ribonucleoside metabolic process	GO:0009119	245	0.013
negative regulation of homeostatic process	GO:0032845	71	0.013
locomotory behavior	GO:0007626	195	0.013
pigment metabolic process	GO:0042440	32	0.013
organic hydroxy compound metabolic process	GO:1901615	203	0.013
dicarboxylic acid metabolic process	GO:0043648	18	0.013
negative regulation of intracellular signal transduction	GO:1902532	167	0.013
germ cell development	GO:0007281	185	0.013
ribose phosphate biosynthetic process	GO:0046390	59	0.013
protein targeting to peroxisome	GO:0006625	4	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.013
reactive nitrogen species metabolic process	GO:2001057	0	0.013
regulation of homeostatic process	GO:0032844	182	0.013
calcium ion homeostasis	GO:0055074	127	0.013
regulation of transmembrane transport	GO:0034762	128	0.012
response to organic cyclic compound	GO:0014070	198	0.012
apoptotic signaling pathway	GO:0097190	306	0.012	Mouse
placenta development	GO:0001890	140	0.012
establishment of protein localization to organelle	GO:0072594	118	0.012	Mouse
amide transport	GO:0042886	138	0.012	Mouse
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.012
sequestering of metal ion	GO:0051238	19	0.012
neuron apoptotic process	GO:0051402	142	0.012	Rat
porphyrin containing compound biosynthetic process	GO:0006779	16	0.012
cofactor biosynthetic process	GO:0051188	41	0.012
multi multicellular organism process	GO:0044706	109	0.011
t cell activation	GO:0042110	289	0.011	Mouse
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.011
organic anion transport	GO:0015711	137	0.011
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.011	Mouse
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.011
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.011
negative regulation of cell development	GO:0010721	169	0.011
endocytosis	GO:0006897	168	0.011	Fly
positive regulation of proteolysis	GO:0045862	85	0.011
mitochondrial protein processing	GO:0034982	5	0.011
embryonic epithelial tube formation	GO:0001838	130	0.011
carboxylic acid transport	GO:0046942	100	0.011
carboxylic acid biosynthetic process	GO:0046394	86	0.011
epithelial cell proliferation	GO:0050673	174	0.011
small molecule catabolic process	GO:0044282	71	0.011
nucleoside phosphate biosynthetic process	GO:1901293	79	0.011
acyl coa biosynthetic process	GO:0071616	7	0.011
response to oxidative stress	GO:0006979	123	0.011
reactive oxygen species biosynthetic process	GO:1903409	8	0.011
cellular calcium ion homeostasis	GO:0006874	119	0.011
leukocyte differentiation	GO:0002521	342	0.010	Mouse
positive regulation of protein modification process	GO:0031401	299	0.010	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.010	Mouse
acyl coa metabolic process	GO:0006637	19	0.010
calcium ion transport	GO:0006816	159	0.010

Prdx3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.365
inherited metabolic disorder	DOID:655	0.283
disease of cellular proliferation	DOID:14566	0.037
cancer	DOID:162	0.037
organ system cancer	DOID:0050686	0.017
nervous system disease	DOID:863	0.014
disease of anatomical entity	DOID:7	0.014
central nervous system disease	DOID:331	0.012
neurodegenerative disease	DOID:1289	0.012

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