IMP: Integrative Multi-species Prediction

Mus musculus

39 known processes

Prf1

perforin 1 (pore forming protein)

(Aliases: Pfp,Prf-1,Pfn)

Entrez: 18646
Ensembl: ENSMUSG00000037202
UniProtKB: P10820
UniProtKB: A2RSY7

Process Predictions
Disease Predictions

Prf1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.997
negative regulation of inflammatory response to antigenic stimulus	GO:0002862	10	0.993
natural killer cell activation	GO:0030101	44	0.988
defense response to bacterium	GO:0042742	119	0.985
adaptive immune response	GO:0002250	155	0.978
leukocyte mediated immunity	GO:0002443	174	0.977
natural killer cell mediated cytotoxicity	GO:0042267	29	0.971
cell killing	GO:0001906	67	0.970
natural killer cell degranulation	GO:0043320	3	0.966
lymphocyte mediated immunity	GO:0002449	139	0.963
somatic diversification of immune receptors	GO:0002200	53	0.955
cell fate commitment	GO:0045165	210	0.952
peptidyl tyrosine modification	GO:0018212	145	0.950
dna metabolic process	GO:0006259	303	0.935
leukocyte proliferation	GO:0070661	172	0.929
leukocyte mediated cytotoxicity	GO:0001909	62	0.908
cell activation involved in immune response	GO:0002263	126	0.895
regulation of leukocyte mediated immunity	GO:0002703	104	0.887
regulation of cellular amine metabolic process	GO:0033238	20	0.884
cellular ketone metabolic process	GO:0042180	84	0.878
natural killer cell mediated immunity	GO:0002228	29	0.877
peptidyl tyrosine phosphorylation	GO:0018108	143	0.865
leukocyte activation involved in immune response	GO:0002366	126	0.839
positive regulation of b cell mediated immunity	GO:0002714	26	0.831
somatic diversification of immunoglobulins involved in immune response	GO:0002208	36	0.831
lymphocyte proliferation	GO:0046651	164	0.819
t cell activation	GO:0042110	289	0.815
amine metabolic process	GO:0009308	45	0.812
dna recombination	GO:0006310	92	0.808
regulation of lymphocyte mediated immunity	GO:0002706	84	0.794
t cell mediated immunity	GO:0002456	50	0.794
peptidyl amino acid modification	GO:0018193	336	0.792
somatic cell dna recombination	GO:0016444	51	0.791
negative regulation of lymphocyte activation	GO:0051250	91	0.791
epithelial cell proliferation	GO:0050673	174	0.790
natural killer cell activation involved in immune response	GO:0002323	10	0.785
reactive oxygen species metabolic process	GO:0072593	84	0.782
defense response to other organism	GO:0098542	197	0.781
regulation of inflammatory response to antigenic stimulus	GO:0002861	21	0.775
negative regulation of immune effector process	GO:0002698	55	0.774
cellular response to cytokine stimulus	GO:0071345	189	0.772
positive regulation of isotype switching to igg isotypes	GO:0048304	7	0.770
b cell activation	GO:0042113	161	0.765
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.762
somatic diversification of immunoglobulins	GO:0016445	43	0.750
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.746
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	51	0.742
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.722
regulation of dna recombination	GO:0000018	34	0.722
regulation of lymphocyte activation	GO:0051249	240	0.718
cytokine mediated signaling pathway	GO:0019221	115	0.718
somatic recombination of immunoglobulin gene segments	GO:0016447	42	0.717
immune effector process	GO:0002252	321	0.713
positive regulation of activated t cell proliferation	GO:0042104	8	0.709
jak stat cascade	GO:0007259	42	0.700
leukocyte homeostasis	GO:0001776	79	0.680
regulation of isotype switching	GO:0045191	22	0.678
regulation of t cell activation	GO:0050863	170	0.672
regulation of b cell activation	GO:0050864	81	0.672
negative regulation of inflammatory response	GO:0050728	61	0.671
cellular amine metabolic process	GO:0044106	44	0.671
immunoglobulin mediated immune response	GO:0016064	69	0.667
t cell proliferation	GO:0042098	120	0.631
positive regulation of lymphocyte proliferation	GO:0050671	70	0.630
response to peptide	GO:1901652	136	0.630
cell type specific apoptotic process	GO:0097285	268	0.628
lymphocyte activation involved in immune response	GO:0002285	93	0.612
leukocyte apoptotic process	GO:0071887	71	0.611
t cell differentiation	GO:0030217	174	0.605
regulation of leukocyte proliferation	GO:0070663	121	0.592
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.591
t cell activation involved in immune response	GO:0002286	43	0.588
regulation of cell activation	GO:0050865	289	0.585
stem cell maintenance	GO:0019827	130	0.580
innate immune response	GO:0045087	157	0.569
regulation of peptidase activity	GO:0052547	96	0.562
negative regulation of interleukin 5 production	GO:0032714	4	0.560
regulation of b cell mediated immunity	GO:0002712	37	0.559
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.555
regulation of endopeptidase activity	GO:0052548	89	0.546
cytokine biosynthetic process	GO:0042089	68	0.543
cellular response to lipid	GO:0071396	145	0.541
regulation of lymphocyte differentiation	GO:0045619	107	0.539
regulation of interleukin 6 production	GO:0032675	55	0.537
leukocyte degranulation	GO:0043299	27	0.534
regulation of b cell differentiation	GO:0045577	23	0.529
regulation of epithelial cell proliferation	GO:0050678	141	0.526
regulation of cellular amino acid metabolic process	GO:0006521	5	0.521
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.516
myeloid cell activation involved in immune response	GO:0002275	34	0.516
regulation of lymphocyte proliferation	GO:0050670	117	0.516
immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	43	0.516
t cell selection	GO:0045058	34	0.508
production of molecular mediator of immune response	GO:0002440	103	0.505
negative regulation of cell activation	GO:0050866	111	0.503
regulation of leukocyte differentiation	GO:1902105	159	0.499
homeostasis of number of cells	GO:0048872	210	0.492
regulation of cell cycle	GO:0051726	281	0.492
isotype switching to igg isotypes	GO:0048291	10	0.489
melanocyte differentiation	GO:0030318	25	0.489
regulation of interleukin 2 production	GO:0032663	28	0.487
positive regulation of protein phosphorylation	GO:0001934	242	0.471
myeloid leukocyte mediated immunity	GO:0002444	42	0.470
digestive tract development	GO:0048565	190	0.469
alpha beta t cell lineage commitment	GO:0002363	7	0.468
establishment of melanosome localization	GO:0032401	11	0.460
regulation of tolerance induction dependent upon immune response	GO:0002652	1	0.450
b cell proliferation	GO:0042100	53	0.446
regulation of adaptive immune response	GO:0002819	90	0.441
lymphocyte homeostasis	GO:0002260	64	0.441
cellular response to biotic stimulus	GO:0071216	92	0.441
regulation of angiogenesis	GO:0045765	81	0.438	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.436
regulation of jak stat cascade	GO:0046425	34	0.435
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.435
myeloid cell homeostasis	GO:0002262	114	0.430
isotype switching	GO:0045190	36	0.426
erk1 and erk2 cascade	GO:0070371	77	0.425
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.421
positive regulation of interferon gamma production	GO:0032729	39	0.421
regulation of cellular ketone metabolic process	GO:0010565	66	0.420
positive regulation of production of molecular mediator of immune response	GO:0002702	45	0.418
lymphocyte differentiation	GO:0030098	242	0.415
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.412
positive regulation of t cell proliferation	GO:0042102	52	0.408
somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	36	0.406
cd4 positive cd25 positive alpha beta regulatory t cell differentiation	GO:0002361	4	0.401
negative regulation of adaptive immune response	GO:0002820	25	0.400
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.397
regulation of immunoglobulin mediated immune response	GO:0002889	37	0.395
myeloid cell differentiation	GO:0030099	233	0.392
natural killer cell proliferation	GO:0001787	3	0.390
isotype switching to ige isotypes	GO:0048289	7	0.388
negative regulation of defense response	GO:0031348	77	0.383
myeloid leukocyte differentiation	GO:0002573	119	0.380
immune response activating signal transduction	GO:0002757	116	0.374
cellular amino acid metabolic process	GO:0006520	103	0.365
regulation of body fluid levels	GO:0050878	162	0.362
positive regulation of map kinase activity	GO:0043406	84	0.360
regulated secretory pathway	GO:0045055	32	0.355
positive regulation of protein modification process	GO:0031401	299	0.352
inflammatory response	GO:0006954	244	0.345	Mouse
negative regulation of b cell activation	GO:0050869	27	0.344
regulation of cytokine biosynthetic process	GO:0042035	59	0.340
positive regulation of tumor necrosis factor superfamily cytokine production	GO:1903557	31	0.340
urogenital system development	GO:0001655	261	0.339
cytokine production	GO:0001816	319	0.339
myeloid leukocyte activation	GO:0002274	83	0.335
regulation of cytokine production	GO:0001817	266	0.331
digestive system development	GO:0055123	200	0.329
positive regulation of gamma delta t cell differentiation	GO:0045588	6	0.325
gonad development	GO:0008406	141	0.322
cellular response to dna damage stimulus	GO:0006974	207	0.318
regulation of tyrosine phosphorylation of stat protein	GO:0042509	20	0.314
mast cell proliferation	GO:0070662	4	0.311
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.309
positive regulation of b cell activation	GO:0050871	49	0.306
sphingolipid metabolic process	GO:0006665	45	0.306
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.304
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.297
negative regulation of t cell activation	GO:0050868	65	0.293
cell chemotaxis	GO:0060326	81	0.292
extrinsic apoptotic signaling pathway	GO:0097191	126	0.292
t cell differentiation in thymus	GO:0033077	77	0.290
positive regulation of mitotic cell cycle	GO:0045931	41	0.281
protein maturation	GO:0051604	176	0.278	Mouse
cellular lipid metabolic process	GO:0044255	323	0.277
positive regulation of cytokine production	GO:0001819	174	0.275
cellular response to lipopolysaccharide	GO:0071222	77	0.271
v d j recombination	GO:0033151	14	0.267
tyrosine phosphorylation of stat protein	GO:0007260	23	0.261
regulation of map kinase activity	GO:0043405	120	0.255
positive regulation of isotype switching	GO:0045830	15	0.252
positive regulation of mapk cascade	GO:0043410	170	0.249
growth of symbiont in host	GO:0044117	23	0.248
positive regulation of cell cycle	GO:0045787	92	0.248
cd4 positive or cd8 positive alpha beta t cell lineage commitment	GO:0043369	8	0.247
t helper 1 cell lineage commitment	GO:0002296	2	0.241
regulation of innate immune response	GO:0045088	91	0.237
positive regulation of dna recombination	GO:0045911	17	0.236
negative regulation of chronic inflammatory response	GO:0002677	3	0.236
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.235
response to radiation	GO:0009314	165	0.231
synaptic transmission	GO:0007268	329	0.230
t cell lineage commitment	GO:0002360	13	0.228
regulation of interferon gamma production	GO:0032649	57	0.226
b cell activation involved in immune response	GO:0002312	50	0.222
antibacterial humoral response	GO:0019731	8	0.218
immunoglobulin production	GO:0002377	73	0.218
antibacterial peptide production	GO:0002778	2	0.217
positive regulation of tyrosine phosphorylation of stat protein	GO:0042531	15	0.215
response to growth factor	GO:0070848	198	0.211
response to acid chemical	GO:0001101	111	0.207
pattern recognition receptor signaling pathway	GO:0002221	47	0.205
regulation of kinase activity	GO:0043549	249	0.203
immature b cell differentiation	GO:0002327	10	0.202
negative regulation of immune system process	GO:0002683	209	0.200
interleukin 6 production	GO:0032635	58	0.198
stem cell development	GO:0048864	219	0.198
cytokine production involved in immune response	GO:0002367	34	0.198
humoral immune response	GO:0006959	57	0.198	Mouse
chronic inflammatory response	GO:0002544	9	0.197
myeloid cell apoptotic process	GO:0033028	22	0.194
melanosome transport	GO:0032402	11	0.194
erythrocyte differentiation	GO:0030218	88	0.191
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.190
angiogenesis	GO:0001525	201	0.189	Mouse
digestive tract morphogenesis	GO:0048546	147	0.189
regulation of t cell differentiation	GO:0045580	83	0.189
positive regulation of adaptive immune response	GO:0002821	61	0.185
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.184
response to lipopolysaccharide	GO:0032496	128	0.182
positive regulation of lymphocyte activation	GO:0051251	140	0.180
positive t cell selection	GO:0043368	23	0.179
cardiac muscle cell differentiation	GO:0055007	69	0.179
signal transduction in absence of ligand	GO:0038034	55	0.178
regulation of isotype switching to ige isotypes	GO:0048293	7	0.177
positive regulation of secretion	GO:0051047	130	0.170
positive regulation of innate immune response	GO:0045089	80	0.168
neutrophil mediated immunity	GO:0002446	19	0.166
positive regulation of leukocyte proliferation	GO:0070665	73	0.164
positive regulation of isotype switching to ige isotypes	GO:0048295	4	0.163
t cell differentiation involved in immune response	GO:0002292	30	0.162
positive regulation of cell activation	GO:0050867	158	0.161
defense response to gram positive bacterium	GO:0050830	50	0.159
inflammatory response to antigenic stimulus	GO:0002437	30	0.158
regulation of secretion by cell	GO:1903530	249	0.158
t helper cell differentiation	GO:0042093	28	0.156
t helper cell lineage commitment	GO:0002295	6	0.155
mammary gland epithelial cell proliferation	GO:0033598	24	0.154
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.153
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002823	23	0.153
mitotic nuclear division	GO:0007067	48	0.152
protein processing	GO:0016485	163	0.151	Mouse
response to amino acid	GO:0043200	37	0.151
positive regulation of immune effector process	GO:0002699	107	0.151	Mouse
cd4 positive alpha beta t cell lineage commitment	GO:0043373	6	0.149
exocrine system development	GO:0035272	45	0.146
lung development	GO:0030324	164	0.145
muscle cell proliferation	GO:0033002	52	0.145
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.145
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.144
tumor necrosis factor mediated signaling pathway	GO:0033209	13	0.144
positive regulation of protein kinase activity	GO:0045860	144	0.143
thymic t cell selection	GO:0045061	22	0.142
ameboidal type cell migration	GO:0001667	128	0.141
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	1	0.140
fertilization	GO:0009566	127	0.139
gland development	GO:0048732	330	0.138
regulation of protein kinase activity	GO:0045859	232	0.137
endocrine system development	GO:0035270	98	0.136
t cell homeostasis	GO:0043029	35	0.135
regulation of toll like receptor 4 signaling pathway	GO:0034143	4	0.135
cellular response to molecule of bacterial origin	GO:0071219	83	0.134
positive regulation of kinase activity	GO:0033674	155	0.134
cytotoxic t cell degranulation	GO:0043316	2	0.134
regulation of mast cell proliferation	GO:0070666	4	0.133
response to endoplasmic reticulum stress	GO:0034976	53	0.131
extracellular matrix organization	GO:0030198	147	0.131
b cell mediated immunity	GO:0019724	71	0.130
cellular component assembly involved in morphogenesis	GO:0010927	139	0.130
granulocyte activation	GO:0036230	10	0.130
regulation of immunoglobulin production	GO:0002637	42	0.130
establishment of pigment granule localization	GO:0051905	12	0.129
regulation of chronic inflammatory response to antigenic stimulus	GO:0002874	3	0.129
regulation of prostaglandin endoperoxide synthase activity	GO:0060584	2	0.128
regulation of tyrosine phosphorylation of stat3 protein	GO:0042516	10	0.128
activation of mapk activity	GO:0000187	59	0.128
regulation of interleukin 5 secretion	GO:2000662	2	0.127
positive regulation of proteolysis	GO:0045862	85	0.127
microtubule based process	GO:0007017	236	0.127
epidermis development	GO:0008544	187	0.126
negative regulation of vasculature development	GO:1901343	26	0.126
activation of cysteine type endopeptidase activity	GO:0097202	27	0.125
positive regulation of protein kinase b signaling	GO:0051897	32	0.125
chromatin organization	GO:0006325	206	0.125
leukocyte differentiation	GO:0002521	342	0.124
positive regulation of inflammatory response to antigenic stimulus	GO:0002863	11	0.124
nuclear division	GO:0000280	158	0.124
positive regulation of immunoglobulin mediated immune response	GO:0002891	26	0.123
response to molecule of bacterial origin	GO:0002237	143	0.123
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.123
intracellular protein transport	GO:0006886	204	0.122
organelle fission	GO:0048285	170	0.121
cellular response to amino acid stimulus	GO:0071230	29	0.121
positive regulation of response to wounding	GO:1903036	66	0.120
regulation of proteolysis	GO:0030162	164	0.120
protein targeting	GO:0006605	143	0.120
morphogenesis of a branching epithelium	GO:0061138	193	0.119
hindbrain development	GO:0030902	128	0.119
leukocyte chemotaxis	GO:0030595	69	0.118
positive regulation of cellular amine metabolic process	GO:0033240	5	0.118
regulation of mitosis	GO:0007088	29	0.118
progesterone metabolic process	GO:0042448	4	0.117
positive regulation of immunoglobulin production	GO:0002639	28	0.117
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.115
positive regulation of angiogenesis	GO:0045766	46	0.114	Mouse
positive regulation of jak stat cascade	GO:0046427	22	0.114
defense response to protozoan	GO:0042832	25	0.113
regulation of mapk cascade	GO:0043408	248	0.113
regulation of erk1 and erk2 cascade	GO:0070372	71	0.113
b cell differentiation	GO:0030183	78	0.111
t cell mediated cytotoxicity	GO:0001913	26	0.111
response to hydrogen peroxide	GO:0042542	32	0.110
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.109
organelle assembly	GO:0070925	177	0.109
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.109
positive regulation of defense response	GO:0031349	124	0.109
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.108
muscle cell development	GO:0055001	133	0.107
detection of stimulus	GO:0051606	84	0.107
positive regulation of intracellular transport	GO:0032388	70	0.106
positive regulation of epithelial cell proliferation	GO:0050679	68	0.105
negative regulation of leukocyte differentiation	GO:1902106	51	0.105
regulation of mesenchymal cell proliferation	GO:0010464	37	0.104
positive regulation of notch signaling pathway	GO:0045747	18	0.103
negative regulation of b cell mediated immunity	GO:0002713	7	0.103
detection of external stimulus	GO:0009581	61	0.102
anatomical structure homeostasis	GO:0060249	145	0.102
striated muscle cell development	GO:0055002	125	0.101
regulation of inflammatory response	GO:0050727	147	0.100	Mouse
regulation of regulated secretory pathway	GO:1903305	20	0.099
exocytosis	GO:0006887	121	0.099
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.099
regulation of mitotic cell cycle	GO:0007346	126	0.098
positive regulation of chemotaxis	GO:0050921	38	0.097
macromolecule catabolic process	GO:0009057	281	0.096
response to insulin	GO:0032868	100	0.096
respiratory system development	GO:0060541	190	0.096
stem cell differentiation	GO:0048863	268	0.096
inflammatory cell apoptotic process	GO:0006925	11	0.095
t helper 2 cell differentiation	GO:0045064	12	0.095
regulation of alpha beta t cell differentiation	GO:0046637	35	0.095
alpha beta t cell activation	GO:0046631	91	0.095
regulation of transferase activity	GO:0051338	263	0.093
positive regulation of peptidase activity	GO:0010952	49	0.093
positive regulation of cell cycle process	GO:0090068	61	0.093
cellular response to growth factor stimulus	GO:0071363	197	0.093
regulation of myeloid cell differentiation	GO:0045637	96	0.093
response to organic cyclic compound	GO:0014070	198	0.092
positive regulation of natural killer cell mediated immunity	GO:0002717	16	0.091
antigen receptor mediated signaling pathway	GO:0050851	64	0.091
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.091
negative regulation of molecular function	GO:0044092	258	0.090
response to oxygen levels	GO:0070482	62	0.090
negative regulation of response to wounding	GO:1903035	77	0.090
pigment granule localization	GO:0051875	13	0.089
positive regulation of myeloid cell differentiation	GO:0045639	43	0.089
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.088
regulation of nuclear division	GO:0051783	56	0.086
odontogenesis	GO:0042476	78	0.086
membrane lipid metabolic process	GO:0006643	53	0.086
cellular macromolecule catabolic process	GO:0044265	206	0.086
activation of mapk activity involved in innate immune response	GO:0035419	2	0.085
negative regulation of multi organism process	GO:0043901	68	0.085
mitotic cell cycle	GO:0000278	195	0.085
positive regulation of mitosis	GO:0045840	14	0.084
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.083
osteoclast differentiation	GO:0030316	62	0.083
mucosal associated lymphoid tissue development	GO:0048537	12	0.082
regulation of ion transport	GO:0043269	215	0.082
positive regulation of endopeptidase activity	GO:0010950	43	0.082
alpha beta t cell proliferation	GO:0046633	21	0.081
regulation of interleukin 13 secretion	GO:2000665	2	0.080
lymph node development	GO:0048535	18	0.080
neutrophil apoptotic process	GO:0001781	3	0.080
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.080
rhythmic process	GO:0048511	174	0.080	Rat
muscle tissue development	GO:0060537	308	0.080
response to interleukin 15	GO:0070672	3	0.079
cellular response to peptide	GO:1901653	92	0.079
regulation of toll like receptor 2 signaling pathway	GO:0034135	3	0.079
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.079
prolactin signaling pathway	GO:0038161	5	0.078
phosphatidylinositol 3 kinase signaling	GO:0014065	36	0.078
positive regulation of t cell differentiation	GO:0045582	52	0.078
positive regulation of programmed cell death	GO:0043068	218	0.078
regionalization	GO:0003002	337	0.076
neutrophil activation	GO:0042119	9	0.076
mammary gland lobule development	GO:0061377	22	0.075
negative regulation of cellular amine metabolic process	GO:0033239	1	0.075
regulation of tumor necrosis factor production	GO:0032680	49	0.074
nuclear transport	GO:0051169	139	0.074
positive regulation of mesenchymal cell proliferation	GO:0002053	33	0.074
chemotaxis	GO:0006935	247	0.074
establishment of protein localization to organelle	GO:0072594	118	0.073
positive regulation of stress activated mapk cascade	GO:0032874	48	0.072
skin development	GO:0043588	220	0.072
regulation of production of molecular mediator of immune response	GO:0002700	65	0.071
negative regulation of hypersensitivity	GO:0002884	3	0.071
positive regulation of translational initiation	GO:0045948	4	0.071
positive regulation of t cell activation	GO:0050870	101	0.070
interleukin 10 secretion	GO:0072608	4	0.070
negative regulation of epithelial cell proliferation	GO:0050680	64	0.069
regulation of jun kinase activity	GO:0043506	40	0.069
t cell receptor signaling pathway	GO:0050852	46	0.069
regulation of protein complex assembly	GO:0043254	83	0.069
positive regulation of behavior	GO:0048520	40	0.069
endodermal cell fate specification	GO:0001714	4	0.069
negative regulation of myeloid cell apoptotic process	GO:0033033	11	0.068
regulation of cell cycle process	GO:0010564	160	0.068
response to protozoan	GO:0001562	28	0.068
positive regulation of apoptotic process	GO:0043065	217	0.067
smooth muscle tissue development	GO:0048745	22	0.066
nucleic acid phosphodiester bond hydrolysis	GO:0090305	49	0.066
positive regulation of b cell differentiation	GO:0045579	13	0.066
negative regulation of cell proliferation	GO:0008285	296	0.065
pigment granule transport	GO:0051904	12	0.065
regulation of alpha beta t cell activation	GO:0046634	53	0.065
regulation of chemotaxis	GO:0050920	53	0.064
regulation of hydrolase activity	GO:0051336	246	0.064
pigment cell differentiation	GO:0050931	27	0.064
organ or tissue specific immune response	GO:0002251	13	0.064
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.063
eosinophil activation	GO:0043307	1	0.062
cellular response to steroid hormone stimulus	GO:0071383	33	0.062
apoptotic signaling pathway	GO:0097190	306	0.062
lung cell differentiation	GO:0060479	30	0.062
glycolipid metabolic process	GO:0006664	25	0.062
inositol lipid mediated signaling	GO:0048017	41	0.061
detection of abiotic stimulus	GO:0009582	60	0.061
negative regulation of growth of symbiont in host	GO:0044130	19	0.060
regulation of secretion	GO:0051046	274	0.060
modulation of growth of symbiont involved in interaction with host	GO:0044144	19	0.060
liposaccharide metabolic process	GO:1903509	27	0.060
respiratory tube development	GO:0030323	167	0.060
regulation of neuron projection development	GO:0010975	169	0.059
alpha beta t cell differentiation	GO:0046632	69	0.059
positive regulation of leukocyte differentiation	GO:1902107	86	0.059
regulation of acute inflammatory response	GO:0002673	27	0.059	Mouse
positive regulation of transferase activity	GO:0051347	167	0.058
sulfur compound metabolic process	GO:0006790	100	0.058
regulation of lipid metabolic process	GO:0019216	118	0.058
cell division	GO:0051301	120	0.058
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.058
positive regulation of tyrosine phosphorylation of stat5 protein	GO:0042523	6	0.058
sensory organ morphogenesis	GO:0090596	242	0.058
striated muscle tissue development	GO:0014706	293	0.058
positive regulation of interleukin 12 production	GO:0032735	21	0.058
positive regulation of mhc class ii biosynthetic process	GO:0045348	4	0.057
regulation of defense response	GO:0031347	233	0.057	Mouse
embryonic organ morphogenesis	GO:0048562	276	0.057
single fertilization	GO:0007338	82	0.057
regulation of myeloid cell apoptotic process	GO:0033032	19	0.057
cytokine metabolic process	GO:0042107	71	0.056
single organism cell adhesion	GO:0098602	156	0.056
negative regulation of hydrolase activity	GO:0051346	71	0.056
negative regulation of protein maturation	GO:1903318	79	0.056
phosphatidylinositol mediated signaling	GO:0048015	41	0.055
muscle cell differentiation	GO:0042692	261	0.055
regulation of vasculature development	GO:1901342	88	0.055	Mouse
learning or memory	GO:0007611	148	0.054
negative regulation of myeloid dendritic cell activation	GO:0030886	3	0.054
transmembrane transport	GO:0055085	412	0.054
interleukin 1 production	GO:0032612	31	0.053
positive regulation of interleukin 2 biosynthetic process	GO:0045086	8	0.053
protein kinase b signaling	GO:0043491	74	0.053
nucleocytoplasmic transport	GO:0006913	139	0.053
nucleotide metabolic process	GO:0009117	332	0.053
organic hydroxy compound metabolic process	GO:1901615	203	0.053
development of primary female sexual characteristics	GO:0046545	73	0.053
negative regulation of interleukin 2 biosynthetic process	GO:0045085	3	0.053
negative regulation of toll like receptor signaling pathway	GO:0034122	14	0.053
histone lysine methylation	GO:0034968	50	0.052
negative regulation of interleukin 6 production	GO:0032715	17	0.052
regulation of chronic inflammatory response	GO:0002676	7	0.052
positive regulation of regulatory t cell differentiation	GO:0045591	4	0.052
regulation of vesicle mediated transport	GO:0060627	139	0.052
immune response regulating signaling pathway	GO:0002764	125	0.051
skeletal muscle organ development	GO:0060538	163	0.051
negative regulation of type 2 immune response	GO:0002829	8	0.050
regulation of growth of symbiont in host	GO:0044126	19	0.050
interleukin 2 biosynthetic process	GO:0042094	15	0.050
face development	GO:0060324	38	0.050
positive regulation of cell death	GO:0010942	224	0.050
regulation of b cell proliferation	GO:0030888	39	0.049
positive regulation of alpha beta t cell activation	GO:0046635	39	0.049
lung alveolus development	GO:0048286	45	0.049
protein acylation	GO:0043543	64	0.049
regulation of cell division	GO:0051302	76	0.049
mast cell activation	GO:0045576	27	0.049
negative regulation of interleukin 2 production	GO:0032703	8	0.049
negative regulation of leukocyte proliferation	GO:0070664	46	0.048

Prf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
cancer	DOID:162	0.667	Human
disease of cellular proliferation	DOID:14566	0.667	Human
organ system cancer	DOID:0050686	0.667	Human
immune system disease	DOID:2914	0.274	Human
disease of anatomical entity	DOID:7	0.274	Human
disease of metabolism	DOID:0014667	0.131
carbohydrate metabolism disease	DOID:0050013	0.131
glucose metabolism disease	DOID:4194	0.131
acquired metabolic disease	DOID:0060158	0.131
immune system cancer	DOID:0060083	0.123	Human
hematologic cancer	DOID:2531	0.123	Human
diabetes mellitus	DOID:9351	0.071

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