Mus musculus

11 known processes

Psmb8

proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

(Aliases: Lmp7,Lmp-7)

Psmb8 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of t cell mediated cytotoxicityGO:0001916151.000
negative regulation of natural killer cell mediated immunityGO:000271651.000
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathwayGO:000248430.998
antigen processing and presentation of peptide antigen via mhc class iGO:000247490.997
antigen processing and presentation via mhc class ibGO:000247580.997
regulation of t cell mediated cytotoxicityGO:0001914180.993
antigen processing and presentation of endogenous peptide antigen via mhc class iGO:001988530.957
natural killer cell mediated cytotoxicityGO:0042267290.934
antigen processing and presentationGO:0019882470.932
antigen processing and presentation of exogenous antigenGO:0019884260.928
t cell mediated cytotoxicityGO:0001913260.916
antigen processing and presentation of endogenous peptide antigen via mhc class ibGO:000247640.903
antigen processing and presentation of peptide antigen via mhc class ibGO:000242850.883
regulation of myd88 independent toll like receptor signaling pathwayGO:003412710.798
regulation of leukocyte mediated cytotoxicityGO:0001910380.786
regulation of natural killer cell mediated cytotoxicityGO:0042269190.745
innate immune responseGO:00450871570.696
antigen processing and presentation of peptide antigenGO:0048002290.689
interspecies interaction between organismsGO:0044419830.683
positive regulation of t cell mediated immunityGO:0002711240.666
antigen processing and presentation of exogenous peptide antigenGO:0002478210.664
regulation of defense responseGO:00313472330.656
antigen processing and presentation of endogenous peptide antigenGO:000248360.637
myosin filament organizationGO:003103330.633
positive regulation of cell killingGO:0031343330.616
lymphocyte mediated immunityGO:00024491390.615
cell killingGO:0001906670.598
viral life cycleGO:0019058360.591
glycosyl compound catabolic processGO:19016582060.581
iron ion import into cellGO:009745940.571
leukocyte mediated cytotoxicityGO:0001909620.546
antigen processing and presentation of exogenous peptide antigen via mhc class ibGO:000247730.529
t cell mediated immunityGO:0002456500.519
regulation of t cell mediated immunityGO:0002709340.518
regulation of tolerance induction dependent upon immune responseGO:000265210.507
lysosomal transportGO:0007041100.504
ribonucleotide metabolic processGO:00092592910.501
cd8 positive alpha beta t cell proliferationGO:003574010.474
natural killer cell mediated immunityGO:0002228290.459
regulation of type i interferon mediated signaling pathwayGO:006033870.434
adaptive immune responseGO:00022501550.424
leukocyte mediated immunityGO:00024431740.411
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.391
posttranscriptional gene silencingGO:0016441100.390
myosin filament assemblyGO:003103420.369
nucleoside triphosphate metabolic processGO:00091412300.351
immune effector processGO:00022523210.344
response to interferon betaGO:0035456220.343
purine containing compound catabolic processGO:00725232130.334
antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathwayGO:000248820.329
negative regulation of innate immune responseGO:0045824170.326
regulation of myd88 dependent toll like receptor signaling pathwayGO:003412420.309
carbohydrate derivative catabolic processGO:19011362310.307
symbiosis encompassing mutualism through parasitismGO:0044403830.300
cellular response to interferon gammaGO:0071346250.299
antigen processing and presentation of endogenous antigenGO:001988360.295
regulation of cell killingGO:0031341400.290
protection from natural killer cell mediated cytotoxicityGO:004227020.268
defense response to protozoanGO:0042832250.268
positive regulation of leukocyte mediated cytotoxicityGO:0001912310.264
purine ribonucleotide catabolic processGO:00091542080.257
purine ribonucleoside triphosphate catabolic processGO:00092071990.257
negative regulation of defense response to virus by hostGO:005068910.255
glycosyl compound metabolic processGO:19016572460.249
ribonucleoside triphosphate catabolic processGO:00092031990.247
defense response to other organismGO:00985421970.245
nucleobase containing small molecule metabolic processGO:00550863520.242
negative regulation of defense responseGO:0031348770.235
regulation of cd8 positive alpha beta t cell activationGO:200118530.233
cellular component assembly involved in morphogenesisGO:00109271390.232
purine nucleoside metabolic processGO:00422782410.229
internal protein amino acid acetylationGO:0006475420.229
cellular response to dna damage stimulusGO:00069742070.221
ribose phosphate metabolic processGO:00196932910.219
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.213
t cell proliferationGO:00420981200.197
transport of virusGO:004679410.196
ribonucleoside triphosphate metabolic processGO:00091992200.193
nucleotide metabolic processGO:00091173320.187
organic cyclic compound catabolic processGO:19013612950.186
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap dependentGO:000248530.184
purine nucleotide metabolic processGO:00061633020.183
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.179
antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathway tap dependentGO:000248920.178
regulation of adaptive immune responseGO:0002819900.178
negative regulation of cell activationGO:00508661110.178
aromatic compound catabolic processGO:00194392860.177
regulation of natural killer cell mediated immunityGO:0002715190.174
nucleoside phosphate metabolic processGO:00067533380.174
rna interferenceGO:001624620.171
mammary gland epithelial cell differentiationGO:0060644130.167
nucleoside triphosphate catabolic processGO:00091432050.166
t cell activationGO:00421102890.164
positive regulation of adaptive immune responseGO:0002821610.164
striated muscle myosin thick filament assemblyGO:007168810.164
actin cytoskeleton organizationGO:00300362200.163
ribonucleoside catabolic processGO:00424542060.163
purine nucleoside triphosphate catabolic processGO:00091462030.161
nucleotide catabolic processGO:00091662170.157
purine ribonucleoside metabolic processGO:00461282410.156
organonitrogen compound catabolic processGO:19015652640.154
organophosphate catabolic processGO:00464342320.152
negative regulation of cell proliferationGO:00082852960.152
cellular nitrogen compound catabolic processGO:00442702800.151
organelle assemblyGO:00709251770.151
guanosine containing compound metabolic processGO:19010681440.149
negative regulation of immune system processGO:00026832090.148
heterocycle catabolic processGO:00467002800.145
positive regulation of leukocyte mediated immunityGO:0002705700.141
antigen processing and presentation of exogenous protein antigen via mhc class ib tap dependentGO:000248130.139
regulation of reactive oxygen species biosynthetic processGO:190342620.139
response to molecule of bacterial originGO:00022371430.135
ribonucleotide catabolic processGO:00092612080.133
response to protozoanGO:0001562280.132
intracellular transport of virusGO:007573310.129
nucleoside metabolic processGO:00091162460.126
positive regulation of tolerance induction dependent upon immune responseGO:000265410.125
regulation of defense response to virus by hostGO:005069180.124
regulation of interferon alpha productionGO:003264750.123
purine nucleoside catabolic processGO:00061522050.121
positive regulation of innate immune responseGO:0045089800.118
positive regulation of lymphocyte mediated immunityGO:0002708620.111
intracellular protein transportGO:00068862040.109
purine ribonucleoside triphosphate metabolic processGO:00092052200.106
methylationGO:00322591340.104
cellular response to molecule of bacterial originGO:0071219830.102
gene silencingGO:0016458380.100
cd4 positive alpha beta t cell lineage commitmentGO:004337360.100
positive regulation of cytokine productionGO:00018191740.098
positive regulation of interferon alpha productionGO:003272740.094
response to metal ionGO:0010038470.093
keratinocyte differentiationGO:0030216480.093
positive regulation of rig i signaling pathwayGO:190024610.091
positive regulation of response to cytokine stimulusGO:0060760110.091
nucleoside phosphate catabolic processGO:19012922220.089
positive regulation of peptidase activityGO:0010952490.089
cellular macromolecule catabolic processGO:00442652060.088
purine ribonucleoside catabolic processGO:00461302050.088
regulation of lymphocyte mediated immunityGO:0002706840.086
antigen processing and presentation of exogenous peptide antigen via mhc class iGO:004259060.086
positive regulation of proteolysisGO:0045862850.083
negative regulation of immune effector processGO:0002698550.082
leukocyte proliferationGO:00706611720.082
ubiquitin dependent protein catabolic processGO:00065111290.081
negative regulation of lymphocyte activationGO:0051250910.080
purine nucleotide catabolic processGO:00061952110.080
response to lipopolysaccharideGO:00324961280.080
regulation of dna templated transcription initiationGO:200014270.079
modification dependent protein catabolic processGO:00199411330.079
negative regulation of interferon beta productionGO:003268830.076
cation transportGO:00068123990.076
regulation of t cell activationGO:00508631700.076
t helper 17 cell lineage commitmentGO:007254040.076
ribonucleoside metabolic processGO:00091192450.075
purine nucleoside triphosphate metabolic processGO:00091442260.075
defense response to gram negative bacteriumGO:0050829280.075
regulation of cytoplasmic transportGO:19036491120.074
regulation of multi organism processGO:00439001110.074
protein catabolic processGO:00301632210.072
iron ion homeostasisGO:0055072360.071
negative regulation of lymphocyte mediated immunityGO:0002707210.070
lymphocyte proliferationGO:00466511640.070
gtp metabolic processGO:00460391440.069
metal ion homeostasisGO:00550651890.069
positive regulation of immune effector processGO:00026991070.069
muscle cell developmentGO:00550011330.069
iron ion importGO:009728650.068
purine ribonucleotide metabolic processGO:00091502900.067
cytoplasmic transportGO:00164822340.065
viral processGO:0016032410.064
regulation of t cell proliferationGO:0042129920.062
response to organic cyclic compoundGO:00140701980.062
striated muscle cell developmentGO:00550021250.062
tolerance induction dependent upon immune responseGO:000246110.059
regulation of cellular amine metabolic processGO:0033238200.058
actomyosin structure organizationGO:0031032560.057
protein methylationGO:0006479810.057
positive regulation of hydrolase activityGO:00513451480.055
purine containing compound metabolic processGO:00725213110.055
autophagyGO:0006914450.055
defense response to bacteriumGO:00427421190.054
negative regulation of t cell activationGO:0050868650.051
defense response to virusGO:0051607680.051
peptidyl lysine methylationGO:0018022290.050
posttranscriptional regulation of gene expressionGO:00106081550.049
multicellular organism growthGO:00352641610.048
regulation of type i interferon productionGO:0032479220.047
female sex differentiationGO:0046660840.047
macromolecule catabolic processGO:00090572810.047
cation homeostasisGO:00550802120.045
regulation of protein ubiquitinationGO:0031396520.045
epidermis developmentGO:00085441870.045
regulation of intracellular protein transportGO:0033157820.044
negative regulation of interferon beta biosynthetic processGO:004535810.043
histone modificationGO:00165701590.042
response to interferon gammaGO:0034341340.042
covalent chromatin modificationGO:00165691630.042
positive t cell selectionGO:0043368230.042
cellular response to cytokine stimulusGO:00713451890.042
positive regulation of defense responseGO:00313491240.041
regulation of innate immune responseGO:0045088910.041
cellular amino acid metabolic processGO:00065201030.040
reactive nitrogen species metabolic processGO:200105700.040
amide transportGO:00428861380.039
epithelial cell proliferationGO:00506731740.039
regulation of lymphocyte activationGO:00512492400.039
interaction with hostGO:0051701220.038
nucleoside catabolic processGO:00091642060.037
lymphocyte activation involved in immune responseGO:0002285930.037
negative regulation of protein modification processGO:00314001630.036
viral genome replicationGO:0019079170.036
transition metal ion homeostasisGO:0055076540.035
cellular response to interferon betaGO:0035458210.035
interleukin 1 productionGO:0032612310.035
regulation of interferon gamma productionGO:0032649570.034
regulation of proteolysisGO:00301621640.033
regulation of endopeptidase activityGO:0052548890.033
negative regulation of natural killer cell mediated cytotoxicityGO:004595350.033
cytokine productionGO:00018163190.032
regulation of nucleotide metabolic processGO:00061401690.032
muscle cell differentiationGO:00426922610.032
positive regulation of type i interferon productionGO:0032481140.032
nitrogen compound transportGO:00717052710.032
proteolysis involved in cellular protein catabolic processGO:00516031470.031
cellular protein complex assemblyGO:00436231160.031
import into cellGO:009865780.030
myofibril assemblyGO:0030239340.030
regulation of cellular ketone metabolic processGO:0010565660.030
reactive oxygen species metabolic processGO:0072593840.030
phagocytosisGO:0006909660.029
type i interferon productionGO:0032606290.029
positive regulation of type i interferon mediated signaling pathwayGO:006034040.028
regulation of cd8 positive alpha beta t cell proliferationGO:200056410.028
chromatin organizationGO:00063252060.028
regulation of autophagyGO:0010506300.028
guanosine containing compound catabolic processGO:19010691440.028
protein modification by small protein conjugation or removalGO:00706472070.028
regulation of cytokine biosynthetic processGO:0042035590.028
positive regulation of interferon gamma productionGO:0032729390.027
negative regulation of t cell differentiationGO:0045581230.027
positive regulation of dna templated transcription initiationGO:200014450.027
pattern recognition receptor signaling pathwayGO:0002221470.026
response to radiationGO:00093141650.026
ear developmentGO:00435832000.026
regulation of metal ion transportGO:00109591060.026
regulation of hydrolase activityGO:00513362460.026
regulation of interleukin 1 alpha productionGO:003265040.026
transcription initiation from rna polymerase ii promoterGO:000636780.026
atp metabolic processGO:0046034750.025
reactive oxygen species biosynthetic processGO:190340980.025
positive regulation of cellular component biogenesisGO:0044089940.025
purine nucleoside monophosphate metabolic processGO:0009126810.025
myd88 independent toll like receptor signaling pathwayGO:000275630.025
modification dependent macromolecule catabolic processGO:00436321330.025
regulation of response to biotic stimulusGO:0002831380.025
regulation of reactive oxygen species metabolic processGO:2000377400.025
negative regulation of protein metabolic processGO:00512482820.024
negative regulation of necroptotic processGO:006054690.024
gtp catabolic processGO:00061841430.024
regulation of intracellular transportGO:00323861590.024
muscle tissue developmentGO:00605373080.024
negative regulation of phosphorylationGO:00423261660.023
apoptotic signaling pathwayGO:00971903060.023
purine ribonucleoside monophosphate catabolic processGO:0009169570.023
t helper 17 cell differentiationGO:007253970.022
positive regulation of transcription initiation from rna polymerase ii promoterGO:006026150.022
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.022
peptide transportGO:00158331330.022
regulation of leukocyte mediated immunityGO:00027031040.022
interferon beta productionGO:0032608160.022
leukocyte activation involved in immune responseGO:00023661260.022
negative regulation of phosphorus metabolic processGO:00105631840.021
protein polymerizationGO:0051258570.021
macromolecule methylationGO:00434141200.021
regulation of membrane potentialGO:00423911920.021
positive regulation of cellular amine metabolic processGO:003324050.021
chromatin modificationGO:00165681870.021
leukocyte differentiationGO:00025213420.021
regulation of vasculature developmentGO:1901342880.021
response to type i interferonGO:0034340120.021
cd8 positive alpha beta t cell differentiationGO:004337490.020
regulation of protein transportGO:00512231630.020
sensory system developmentGO:004888030.020
inflammatory responseGO:00069542440.020
syncytium formationGO:0006949430.020
alpha beta t cell activationGO:0046631910.020
blood vessel morphogenesisGO:00485142850.020
negative regulation of cellular amine metabolic processGO:003323910.020
respiratory system developmentGO:00605411900.020
regulation of peptidase activityGO:0052547960.020
positive regulation of reactive oxygen species biosynthetic processGO:190342820.020
glycoprotein metabolic processGO:00091001160.020
lymphocyte differentiationGO:00300982420.020
cellular response to interferon alphaGO:003545740.020
pyrimidine containing compound catabolic processGO:007252930.019
regulation of hormone levelsGO:00108172110.019
regulation of cellular catabolic processGO:00313292420.019
cellular amine metabolic processGO:0044106440.019
central nervous system neuron differentiationGO:00219531620.019
sequestering of metal ionGO:0051238190.019
regulation of alpha beta t cell proliferationGO:0046640180.018
cellular protein catabolic processGO:00442571550.018
ribonucleoside monophosphate metabolic processGO:0009161800.018
maintenance of locationGO:0051235890.018
regulation of lymphocyte proliferationGO:00506701170.018
negative regulation of cell killingGO:003134280.018
cellular response to hormone stimulusGO:00328701500.018
positive regulation of reactive oxygen species metabolic processGO:2000379110.018
inorganic cation import into cellGO:009865940.018
b cell activationGO:00421131610.017
regulation of protein localizationGO:00328802310.017
male gamete generationGO:00482322850.017
negative regulation of cellular protein metabolic processGO:00322692470.017
syncytium formation by plasma membrane fusionGO:0000768420.017
cell fate commitmentGO:00451652100.017
proteasomal protein catabolic processGO:0010498980.017
ras protein signal transductionGO:0007265770.017
regulation of neuron apoptotic processGO:00435231220.017
immunoglobulin mediated immune responseGO:0016064690.017
dephosphorylationGO:00163111290.017
protein acylationGO:0043543640.017
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.017
regulation of purine nucleotide metabolic processGO:19005421690.017
cellular homeostasisGO:00197252400.017
positive regulation of cytosolic calcium ion concentrationGO:0007204650.017
response to dsrnaGO:0043331300.017
negative regulation of t cell proliferationGO:0042130380.017
ribonucleoside monophosphate catabolic processGO:0009158570.017
calcium ion transportGO:00068161590.017
regulation of cytokine productionGO:00018172660.017
cell adhesionGO:00071553290.016
negative regulation of regulatory t cell differentiationGO:004559020.016
cellular response to lipidGO:00713961450.016
response to cadmium ionGO:004668680.016
gene silencing by rnaGO:0031047190.016
protein refoldingGO:004202610.016
peptidyl lysine modificationGO:0018205770.016
defense response to gram positive bacteriumGO:0050830500.016
skin developmentGO:00435882200.016
negative regulation of leukocyte mediated immunityGO:0002704290.016
small gtpase mediated signal transductionGO:0007264970.016
negative regulation of intracellular signal transductionGO:19025321670.016
regulation of cell cycleGO:00517262810.016
regulation of establishment of protein localizationGO:00702011810.016
spermatogenesisGO:00072832840.016
cellular response to ammonium ionGO:007124220.016
regulation of interferon beta biosynthetic processGO:004535740.016
negative regulation of epithelial cell proliferationGO:0050680640.016
peptide metabolic processGO:0006518460.015
positive regulation of apoptotic signaling pathwayGO:2001235950.015
cellular metal ion homeostasisGO:00068751510.015
negative regulation of intracellular protein transportGO:0090317270.015
arp2 3 complex mediated actin nucleationGO:003431430.015
cellular ketone metabolic processGO:0042180840.015
negative regulation of viral transcriptionGO:003289730.015
positive regulation of protein complex assemblyGO:0031334450.015
endocytosisGO:00068971680.014
tube formationGO:00351481400.014
hormone biosynthetic processGO:0042446160.014
regulation of defense response to bacteriumGO:190042430.014
lung developmentGO:00303241640.014
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.014
protein kinase b signalingGO:0043491740.014
neural tube developmentGO:00219151600.014
epithelial tube formationGO:00721751300.014
production of molecular mediator of immune responseGO:00024401030.014
interferon gamma productionGO:0032609670.014
positive regulation of cellular amino acid metabolic processGO:004576430.014
regulation of dna bindingGO:0051101390.014
regulation of arp2 3 complex mediated actin nucleationGO:003431510.014
neuron apoptotic processGO:00514021420.014
negative regulation of intracellular transportGO:0032387380.014
protein ubiquitinationGO:00165671710.013
glucose homeostasisGO:00425931280.013
epithelial tube morphogenesisGO:00605623030.013
phagolysosome assemblyGO:000184530.013
angiogenesisGO:00015252010.013
neuron deathGO:00709971540.013
nucleocytoplasmic transportGO:00069131390.013
morphogenesis of embryonic epitheliumGO:00163311590.013
positive regulation of antigen processing and presentationGO:0002579100.013
purine ribonucleoside monophosphate metabolic processGO:0009167800.013
posttranscriptional gene silencing by rnaGO:0035194100.013
regulation of chromosome organizationGO:0033044830.012
humoral immune responseGO:0006959570.012
regulation of lipid metabolic processGO:00192161180.012
negative regulation of molecular functionGO:00440922580.012
myotube differentiationGO:00149021050.012
protein oligomerizationGO:0051259670.012
engulfment of apoptotic cellGO:004365230.012
response to drugGO:0042493750.012
pallium developmentGO:00215431200.012
actin filament polymerizationGO:0030041440.012
striated muscle tissue developmentGO:00147062930.012
t cell differentiationGO:00302171740.012
nuclear transportGO:00511691390.012
negative regulation of cell cycleGO:00457861230.012
cellular divalent inorganic cation homeostasisGO:00725031270.012
regulation of protein complex assemblyGO:0043254830.012
cellular response to type i interferonGO:0071357100.012
regulation of organelle organizationGO:00330432890.012
response to organonitrogen compoundGO:00102432460.012
regulation of protein targetingGO:1903533610.012
cellular chemical homeostasisGO:00550822150.011
oxidation reduction processGO:00551143420.011
negative regulation of protein phosphorylationGO:00019331260.011
response to inorganic substanceGO:0010035960.011
positive regulation of purine nucleotide metabolic processGO:19005441140.011
embryonic epithelial tube formationGO:00018381300.011
response to light stimulusGO:00094161350.011
carbohydrate homeostasisGO:00335001280.011
positive regulation of actin nucleationGO:005112730.011
antimicrobial peptide biosynthetic processGO:000277720.011
transition metal ion transportGO:0000041380.011
hair follicle developmentGO:0001942850.011
macrophage migration inhibitory factor signaling pathwayGO:003569120.011
mitochondrion organizationGO:00070051340.011
hormone metabolic processGO:0042445860.011
positive regulation of nucleotide metabolic processGO:00459811140.011
renal system developmentGO:00720012250.011
purine nucleoside monophosphate catabolic processGO:0009128580.011
regulation of gtp catabolic processGO:00331241130.011
connective tissue developmentGO:00614481790.011
alpha beta t cell differentiationGO:0046632690.010
cytokine secretionGO:0050663720.010
positive regulation of interleukin 1 alpha secretionGO:005071730.010
peptidyl lysine acetylationGO:0018394450.010
positive regulation of bindingGO:0051099490.010
cell substrate adhesionGO:00315891300.010
cd4 positive or cd8 positive alpha beta t cell lineage commitmentGO:004336980.010
protein importGO:00170381010.010
regulation of system processGO:00440572000.010
myeloid cell differentiationGO:00300992330.010
rac protein signal transductionGO:0016601130.010
response to peptide hormoneGO:00434341270.010
negative regulation of leukocyte differentiationGO:1902106510.010
respiratory tube developmentGO:00303231670.010
response to peptideGO:19016521360.010
regulation of purine nucleotide catabolic processGO:00331211220.010
regulation of neuron deathGO:19012141340.010

Psmb8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:291400.234
disease of anatomical entityDOID:700.234
combined t cell and b cell immunodeficiencyDOID:62800.180
primary immunodeficiency diseaseDOID:61200.180
severe combined immunodeficiencyDOID:62700.128
nervous system diseaseDOID:86300.027
gastrointestinal system cancerDOID:311900.014
cancerDOID:16200.014
disease of cellular proliferationDOID:1456600.014
organ system cancerDOID:005068600.014
lung cancerDOID:132400.014
respiratory system cancerDOID:005061500.014