IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Psmd4

proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

(Aliases: angiocidin,Af1,Mcb1)

Entrez: 19185
Ensembl: ENSMUSG00000005625
UniProtKB: Q3ULG4
UniProtKB: O35226

Process Predictions
Disease Predictions

Psmd4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
proteasome assembly	GO:0043248	1	0.997
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.990
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.986
protein catabolic process	GO:0030163	221	0.984	Yeast Worm
proteasomal protein catabolic process	GO:0010498	98	0.983
modification dependent macromolecule catabolic process	GO:0043632	133	0.979	Yeast Worm
cellular protein catabolic process	GO:0044257	155	0.965	Yeast Worm
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.950
macromolecule catabolic process	GO:0009057	281	0.910	Yeast Worm
proteasomal ubiquitin independent protein catabolic process	GO:0010499	1	0.909
positive regulation of transcription initiation from rna polymerase ii promoter	GO:0060261	5	0.902
modification dependent protein catabolic process	GO:0019941	133	0.896	Yeast Worm
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.871	Yeast Worm
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.859
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.802
cellular macromolecule catabolic process	GO:0044265	206	0.703	Yeast Worm
cellular response to dna damage stimulus	GO:0006974	207	0.690	Fly
ubiquitin dependent protein catabolic process	GO:0006511	129	0.647	Yeast Worm
organelle fission	GO:0048285	170	0.595
microtubule cytoskeleton organization involved in mitosis	GO:1902850	4	0.595
purine nucleoside metabolic process	GO:0042278	241	0.593
blastocyst development	GO:0001824	80	0.563
regulation of inclusion body assembly	GO:0090083	1	0.539
rna catabolic process	GO:0006401	29	0.522
purine ribonucleotide metabolic process	GO:0009150	290	0.518
regulation of dna templated transcription initiation	GO:2000142	7	0.512
positive regulation of dna templated transcription initiation	GO:2000144	5	0.504
transcription initiation from rna polymerase ii promoter	GO:0006367	8	0.496
nuclear division	GO:0000280	158	0.445
purine ribonucleoside metabolic process	GO:0046128	241	0.424
protein dna complex subunit organization	GO:0071824	28	0.401
positive regulation of cellular component biogenesis	GO:0044089	94	0.366
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.364
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.360
mitotic spindle organization	GO:0007052	10	0.319
mitotic cell cycle	GO:0000278	195	0.291
carbohydrate derivative catabolic process	GO:1901136	231	0.291
regulation of protein complex assembly	GO:0043254	83	0.290
positive regulation of protein complex assembly	GO:0031334	45	0.288
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.281
microtubule based process	GO:0007017	236	0.269
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.254
ribonucleoside metabolic process	GO:0009119	245	0.252
protein modification by small protein conjugation	GO:0032446	187	0.251	Fly
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.219
protein ubiquitination	GO:0016567	171	0.215	Fly
dna metabolic process	GO:0006259	303	0.200
nucleoside metabolic process	GO:0009116	246	0.198
regulation of transcription initiation from rna polymerase ii promoter	GO:0060260	6	0.198
ribonucleotide catabolic process	GO:0009261	208	0.193
nucleoside triphosphate metabolic process	GO:0009141	230	0.185
purine containing compound metabolic process	GO:0072521	311	0.182
positive regulation of dna templated transcription elongation	GO:0032786	2	0.173
gonad development	GO:0008406	141	0.169
purine nucleoside catabolic process	GO:0006152	205	0.160
atp catabolic process	GO:0006200	55	0.158
purine nucleotide metabolic process	GO:0006163	302	0.156
atp metabolic process	GO:0046034	75	0.154
dna templated transcription initiation	GO:0006352	13	0.152
cellular protein complex assembly	GO:0043623	116	0.149
nucleotide catabolic process	GO:0009166	217	0.146
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.135
nucleoside phosphate catabolic process	GO:1901292	222	0.131
positive regulation of hydrolase activity	GO:0051345	148	0.130
ribose phosphate metabolic process	GO:0019693	291	0.130
positive regulation of nucleotide catabolic process	GO:0030813	88	0.126
ovarian follicle development	GO:0001541	40	0.125
purine containing compound catabolic process	GO:0072523	213	0.119
mitotic cell cycle process	GO:1903047	159	0.119
spindle organization	GO:0007051	28	0.116
protein modification by small protein removal	GO:0070646	21	0.115
nucleoside monophosphate metabolic process	GO:0009123	85	0.113
organelle assembly	GO:0070925	177	0.104
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.102
cytoplasmic translational initiation	GO:0002183	3	0.102
regulation of cellular component biogenesis	GO:0044087	181	0.099
ribonucleotide metabolic process	GO:0009259	291	0.095
mitotic cytokinesis	GO:0000281	4	0.093
nucleoside monophosphate catabolic process	GO:0009125	59	0.092
nucleoside catabolic process	GO:0009164	206	0.090
protein deubiquitination	GO:0016579	19	0.088
purine nucleotide catabolic process	GO:0006195	211	0.088
regulation of organelle organization	GO:0033043	289	0.087
membrane fusion	GO:0061025	38	0.084
regulation of protein catabolic process	GO:0042176	108	0.084
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.082
exosomal secretion	GO:1990182	1	0.078
positive regulation of cellular catabolic process	GO:0031331	148	0.076
heterocycle catabolic process	GO:0046700	280	0.076
nucleoside triphosphate catabolic process	GO:0009143	205	0.074
regulation of chromosome organization	GO:0033044	83	0.074
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.073
positive regulation of protein catabolic process	GO:0045732	60	0.072
multicellular organismal aging	GO:0010259	24	0.070	Worm
cell division	GO:0051301	120	0.070
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.069
glycosyl compound catabolic process	GO:1901658	206	0.066
glycosyl compound metabolic process	GO:1901657	246	0.063
copii coated vesicle budding	GO:0090114	2	0.063
spindle assembly involved in mitosis	GO:0090307	4	0.062
negative regulation of neuron apoptotic process	GO:0043524	92	0.062
mitochondrial fusion	GO:0008053	9	0.061
purine ribonucleotide catabolic process	GO:0009154	208	0.061
positive regulation of gtpase activity	GO:0043547	85	0.060
response to misfolded protein	GO:0051788	5	0.055
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.055
chromatin organization	GO:0006325	206	0.055
ovulation cycle	GO:0042698	59	0.054
organophosphate catabolic process	GO:0046434	232	0.054
protein polymerization	GO:0051258	57	0.054
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.053
mitotic nuclear division	GO:0007067	48	0.053
regulation of actin filament polymerization	GO:0030833	38	0.052
positive regulation of protein modification process	GO:0031401	299	0.052
regulation of hydrolase activity	GO:0051336	246	0.049
nucleobase containing small molecule metabolic process	GO:0055086	352	0.049
regulation of feeding behavior	GO:0060259	3	0.049
mitotic sister chromatid segregation	GO:0000070	14	0.048
aromatic compound catabolic process	GO:0019439	286	0.048
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	23	0.048
amine metabolic process	GO:0009308	45	0.047
neural tube formation	GO:0001841	108	0.045
positive regulation of proteolysis	GO:0045862	85	0.044
meiotic cell cycle process	GO:1903046	77	0.044
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	31	0.043
female sex differentiation	GO:0046660	84	0.043
inner cell mass cell proliferation	GO:0001833	15	0.042
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	40	0.042
meiosis i	GO:0007127	60	0.042
sister chromatid segregation	GO:0000819	20	0.042
dna repair	GO:0006281	107	0.041
regulation of cellular protein catabolic process	GO:1903362	61	0.041
cellular response to misfolded protein	GO:0071218	5	0.040
positive regulation of cellular protein catabolic process	GO:1903364	34	0.040
negative regulation of protein metabolic process	GO:0051248	282	0.039
regulation of cell cycle process	GO:0010564	160	0.039
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	15	0.039
microtubule cytoskeleton organization	GO:0000226	157	0.039
meiotic cell cycle	GO:0051321	122	0.039
regulation of cellular catabolic process	GO:0031329	242	0.038
synaptic transmission	GO:0007268	329	0.037
t cell activation	GO:0042110	289	0.037
trna wobble uridine modification	GO:0002098	2	0.037
positive regulation of protein phosphorylation	GO:0001934	242	0.037
t cell proliferation	GO:0042098	120	0.035
positive regulation of cellular amine metabolic process	GO:0033240	5	0.035
development of primary sexual characteristics	GO:0045137	143	0.035
small gtpase mediated signal transduction	GO:0007264	97	0.035
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.035
inclusion body assembly	GO:0070841	3	0.034
regulation of cellular amino acid metabolic process	GO:0006521	5	0.034
cellular amino acid metabolic process	GO:0006520	103	0.033
regulation of proteasomal protein catabolic process	GO:0061136	46	0.033
cellular ketone metabolic process	GO:0042180	84	0.033
regulation of cellular amine metabolic process	GO:0033238	20	0.032
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.032
meiotic nuclear division	GO:0007126	115	0.032
connective tissue development	GO:0061448	179	0.032
translational initiation	GO:0006413	24	0.031
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.031
chromatin modification	GO:0016568	187	0.029
er associated ubiquitin dependent protein catabolic process	GO:0030433	10	0.028
double strand break repair	GO:0006302	48	0.028
regulation of cell division	GO:0051302	76	0.028
organic cyclic compound catabolic process	GO:1901361	295	0.028
regulation of cellular ketone metabolic process	GO:0010565	66	0.028
negative regulation of proteolysis	GO:0045861	74	0.028
positive regulation of nucleoside metabolic process	GO:0045979	91	0.027
histone modification	GO:0016570	159	0.027
nucleotide metabolic process	GO:0009117	332	0.026
dna templated transcription elongation	GO:0006354	13	0.026
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.026
peptidyl amino acid modification	GO:0018193	336	0.026
chromosome segregation	GO:0007059	48	0.025	Fly
chromatin remodeling	GO:0006338	32	0.025
regulation of proteolysis	GO:0030162	164	0.024
regulation of protein ubiquitination	GO:0031396	52	0.023	Fly
eye photoreceptor cell development	GO:0042462	31	0.023
organelle fusion	GO:0048284	28	0.023
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.022	Fly
gliogenesis	GO:0042063	141	0.022
organonitrogen compound catabolic process	GO:1901565	264	0.021
response to endoplasmic reticulum stress	GO:0034976	53	0.021
chromosome separation	GO:0051304	14	0.021
stem cell differentiation	GO:0048863	268	0.021
sperm egg recognition	GO:0035036	37	0.020
cellular amine metabolic process	GO:0044106	44	0.020
positive regulation of protein kinase activity	GO:0045860	144	0.020
negative regulation of cellular protein catabolic process	GO:1903363	22	0.020
male gamete generation	GO:0048232	285	0.020	Worm
guanosine containing compound catabolic process	GO:1901069	144	0.020
cartilage development	GO:0051216	140	0.019
translesion synthesis	GO:0019985	1	0.019
transcription elongation from rna polymerase ii promoter	GO:0006368	9	0.019
regulation of protein deubiquitination	GO:0090085	1	0.019
lipid localization	GO:0010876	126	0.019
exocytosis	GO:0006887	121	0.019
regulation of mitotic sister chromatid segregation	GO:0033047	12	0.019
ras protein signal transduction	GO:0007265	77	0.018
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	56	0.018
response to peptide hormone	GO:0043434	127	0.018
protein maturation	GO:0051604	176	0.018
protein processing	GO:0016485	163	0.018
regulation of translation	GO:0006417	71	0.017
positive regulation of endopeptidase activity	GO:0010950	43	0.017
regulation of nuclear division	GO:0051783	56	0.017
cell adhesion	GO:0007155	329	0.017
negative regulation of intracellular signal transduction	GO:1902532	167	0.017
camera type eye development	GO:0043010	266	0.017
fertilization	GO:0009566	127	0.017
lymphocyte differentiation	GO:0030098	242	0.017
mapk cascade	GO:0000165	281	0.016
negative regulation of protein catabolic process	GO:0042177	36	0.016
regulation of actin cytoskeleton organization	GO:0032956	84	0.016
positive regulation of organelle organization	GO:0010638	128	0.016
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.016
female gonad development	GO:0008585	71	0.016
dna recombination	GO:0006310	92	0.016
protein modification by small protein conjugation or removal	GO:0070647	207	0.016	Fly
regulation of transferase activity	GO:0051338	263	0.016
regulation of cytoskeleton organization	GO:0051493	122	0.016
non recombinational repair	GO:0000726	10	0.016
protein acylation	GO:0043543	64	0.016
protein secretion	GO:0009306	111	0.015
covalent chromatin modification	GO:0016569	163	0.015
intrinsic apoptotic signaling pathway	GO:0097193	132	0.015
calcium ion transport	GO:0006816	159	0.015
regulation of membrane potential	GO:0042391	192	0.015
regulation of protein maturation	GO:1903317	96	0.015
divalent inorganic cation transport	GO:0072511	178	0.015
spermatogenesis	GO:0007283	284	0.015	Worm
cytokine production	GO:0001816	319	0.015
development of primary female sexual characteristics	GO:0046545	73	0.015
regulation of receptor activity	GO:0010469	41	0.015
blood vessel morphogenesis	GO:0048514	285	0.015
positive regulation of peptidase activity	GO:0010952	49	0.015
sensory organ morphogenesis	GO:0090596	242	0.014
regulation of inflammatory response	GO:0050727	147	0.014
negative regulation of proteolysis involved in cellular protein catabolic process	GO:1903051	22	0.014
catecholamine uptake involved in synaptic transmission	GO:0051934	4	0.014
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.014
oocyte construction	GO:0007308	2	0.014
spermatid differentiation	GO:0048515	115	0.014
positive regulation of nucleotide metabolic process	GO:0045981	114	0.014
leukocyte differentiation	GO:0002521	342	0.014
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.014
regulation of actin filament based process	GO:0032970	99	0.014
rhythmic process	GO:0048511	174	0.014
purine ribonucleoside catabolic process	GO:0046130	205	0.013
trna metabolic process	GO:0006399	11	0.013
nucleoside phosphate metabolic process	GO:0006753	338	0.013
regulation of mitotic cell cycle	GO:0007346	126	0.013
mitotic sister chromatid separation	GO:0051306	9	0.013
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.013
oocyte axis specification	GO:0007309	2	0.013
cytokinetic process	GO:0032506	2	0.013
organelle membrane fusion	GO:0090174	1	0.013
skeletal system development	GO:0001501	356	0.013
response to organonitrogen compound	GO:0010243	246	0.013
ossification	GO:0001503	216	0.013
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.013
endomembrane system organization	GO:0010256	147	0.013
cellular response to organonitrogen compound	GO:0071417	145	0.013
positive regulation of transferase activity	GO:0051347	167	0.012
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway	GO:0043162	3	0.012
peptidyl serine phosphorylation	GO:0018105	74	0.012
ameboidal type cell migration	GO:0001667	128	0.012
myeloid cell differentiation	GO:0030099	233	0.012
actin filament organization	GO:0007015	113	0.012
positive regulation of growth hormone receptor signaling pathway	GO:0060399	3	0.012
leukocyte migration	GO:0050900	124	0.012
endocytosis	GO:0006897	168	0.012
alpha beta t cell activation	GO:0046631	91	0.012
metaphase anaphase transition of mitotic cell cycle	GO:0007091	9	0.012
extracellular matrix organization	GO:0030198	147	0.012
norepinephrine secretion	GO:0048243	2	0.012
maintenance of location	GO:0051235	89	0.011
oogenesis	GO:0048477	56	0.011
negative regulation of translational initiation	GO:0045947	4	0.011
cellular homeostasis	GO:0019725	240	0.011
negative regulation of neuron death	GO:1901215	98	0.011
response to transforming growth factor beta	GO:0071559	88	0.011
embryonic organ morphogenesis	GO:0048562	276	0.011
extracellular structure organization	GO:0043062	148	0.011
g protein coupled receptor signaling pathway	GO:0007186	243	0.011
organic hydroxy compound metabolic process	GO:1901615	203	0.011
regulation of translational elongation	GO:0006448	4	0.011
negative regulation of protein maturation	GO:1903318	79	0.011
mature dendritic cell differentiation	GO:0097029	3	0.011
t cell differentiation in thymus	GO:0033077	77	0.011
guanosine containing compound metabolic process	GO:1901068	144	0.011
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.011
regulation of cell activation	GO:0050865	289	0.011
regulation of cell adhesion	GO:0030155	154	0.010
organelle localization	GO:0051640	179	0.010
astrocyte development	GO:0014002	12	0.010
negative regulation of protein processing	GO:0010955	79	0.010
response to inorganic substance	GO:0010035	96	0.010
protein neddylation	GO:0045116	1	0.010

Psmd4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
neuromuscular disease	DOID:440	0.020
nervous system disease	DOID:863	0.020
charcot marie tooth disease	DOID:10595	0.020
disease of anatomical entity	DOID:7	0.020
neuropathy	DOID:870	0.020
disease of metabolism	DOID:0014667	0.013
central nervous system disease	DOID:331	0.011

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