| proteasome assembly | GO:0043248 | 1 | 0.997 | |
| regulation of rna polymerase ii transcriptional preinitiation complex assembly | GO:0045898 | 2 | 0.990 | |
| positive regulation of rna polymerase ii transcriptional preinitiation complex assembly | GO:0045899 | 2 | 0.986 | |
| protein catabolic process | GO:0030163 | 221 | 0.984 | Yeast Worm |
| proteasomal protein catabolic process | GO:0010498 | 98 | 0.983 | |
| modification dependent macromolecule catabolic process | GO:0043632 | 133 | 0.979 | Yeast Worm |
| cellular protein catabolic process | GO:0044257 | 155 | 0.965 | Yeast Worm |
| proteasome mediated ubiquitin dependent protein catabolic process | GO:0043161 | 88 | 0.950 | |
| macromolecule catabolic process | GO:0009057 | 281 | 0.910 | Yeast Worm |
| proteasomal ubiquitin independent protein catabolic process | GO:0010499 | 1 | 0.909 | |
| positive regulation of transcription initiation from rna polymerase ii promoter | GO:0060261 | 5 | 0.902 | |
| modification dependent protein catabolic process | GO:0019941 | 133 | 0.896 | Yeast Worm |
| proteolysis involved in cellular protein catabolic process | GO:0051603 | 147 | 0.871 | Yeast Worm |
| dna templated transcriptional preinitiation complex assembly | GO:0070897 | 4 | 0.859 | |
| rna polymerase ii transcriptional preinitiation complex assembly | GO:0051123 | 3 | 0.802 | |
| cellular macromolecule catabolic process | GO:0044265 | 206 | 0.703 | Yeast Worm |
| cellular response to dna damage stimulus | GO:0006974 | 207 | 0.690 | Fly |
| ubiquitin dependent protein catabolic process | GO:0006511 | 129 | 0.647 | Yeast Worm |
| organelle fission | GO:0048285 | 170 | 0.595 | |
| microtubule cytoskeleton organization involved in mitosis | GO:1902850 | 4 | 0.595 | |
| purine nucleoside metabolic process | GO:0042278 | 241 | 0.593 | |
| blastocyst development | GO:0001824 | 80 | 0.563 | |
| regulation of inclusion body assembly | GO:0090083 | 1 | 0.539 | |
| rna catabolic process | GO:0006401 | 29 | 0.522 | |
| purine ribonucleotide metabolic process | GO:0009150 | 290 | 0.518 | |
| regulation of dna templated transcription initiation | GO:2000142 | 7 | 0.512 | |
| positive regulation of dna templated transcription initiation | GO:2000144 | 5 | 0.504 | |
| transcription initiation from rna polymerase ii promoter | GO:0006367 | 8 | 0.496 | |
| nuclear division | GO:0000280 | 158 | 0.445 | |
| purine ribonucleoside metabolic process | GO:0046128 | 241 | 0.424 | |
| protein dna complex subunit organization | GO:0071824 | 28 | 0.401 | |
| positive regulation of cellular component biogenesis | GO:0044089 | 94 | 0.366 | |
| purine ribonucleoside triphosphate catabolic process | GO:0009207 | 199 | 0.364 | |
| purine ribonucleoside triphosphate metabolic process | GO:0009205 | 220 | 0.360 | |
| mitotic spindle organization | GO:0007052 | 10 | 0.319 | |
| mitotic cell cycle | GO:0000278 | 195 | 0.291 | |
| carbohydrate derivative catabolic process | GO:1901136 | 231 | 0.291 | |
| regulation of protein complex assembly | GO:0043254 | 83 | 0.290 | |
| positive regulation of protein complex assembly | GO:0031334 | 45 | 0.288 | |
| ribonucleoside monophosphate metabolic process | GO:0009161 | 80 | 0.281 | |
| microtubule based process | GO:0007017 | 236 | 0.269 | |
| ribonucleoside monophosphate catabolic process | GO:0009158 | 57 | 0.254 | |
| ribonucleoside metabolic process | GO:0009119 | 245 | 0.252 | |
| protein modification by small protein conjugation | GO:0032446 | 187 | 0.251 | Fly |
| purine nucleoside triphosphate catabolic process | GO:0009146 | 203 | 0.219 | |
| protein ubiquitination | GO:0016567 | 171 | 0.215 | Fly |
| dna metabolic process | GO:0006259 | 303 | 0.200 | |
| nucleoside metabolic process | GO:0009116 | 246 | 0.198 | |
| regulation of transcription initiation from rna polymerase ii promoter | GO:0060260 | 6 | 0.198 | |
| ribonucleotide catabolic process | GO:0009261 | 208 | 0.193 | |
| nucleoside triphosphate metabolic process | GO:0009141 | 230 | 0.185 | |
| purine containing compound metabolic process | GO:0072521 | 311 | 0.182 | |
| positive regulation of dna templated transcription elongation | GO:0032786 | 2 | 0.173 | |
| gonad development | GO:0008406 | 141 | 0.169 | |
| purine nucleoside catabolic process | GO:0006152 | 205 | 0.160 | |
| atp catabolic process | GO:0006200 | 55 | 0.158 | |
| purine nucleotide metabolic process | GO:0006163 | 302 | 0.156 | |
| atp metabolic process | GO:0046034 | 75 | 0.154 | |
| dna templated transcription initiation | GO:0006352 | 13 | 0.152 | |
| cellular protein complex assembly | GO:0043623 | 116 | 0.149 | |
| nucleotide catabolic process | GO:0009166 | 217 | 0.146 | |
| purine nucleoside triphosphate metabolic process | GO:0009144 | 226 | 0.135 | |
| nucleoside phosphate catabolic process | GO:1901292 | 222 | 0.131 | |
| positive regulation of hydrolase activity | GO:0051345 | 148 | 0.130 | |
| ribose phosphate metabolic process | GO:0019693 | 291 | 0.130 | |
| positive regulation of nucleotide catabolic process | GO:0030813 | 88 | 0.126 | |
| ovarian follicle development | GO:0001541 | 40 | 0.125 | |
| purine containing compound catabolic process | GO:0072523 | 213 | 0.119 | |
| mitotic cell cycle process | GO:1903047 | 159 | 0.119 | |
| spindle organization | GO:0007051 | 28 | 0.116 | |
| protein modification by small protein removal | GO:0070646 | 21 | 0.115 | |
| nucleoside monophosphate metabolic process | GO:0009123 | 85 | 0.113 | |
| organelle assembly | GO:0070925 | 177 | 0.104 | |
| ribonucleoside triphosphate catabolic process | GO:0009203 | 199 | 0.102 | |
| cytoplasmic translational initiation | GO:0002183 | 3 | 0.102 | |
| regulation of cellular component biogenesis | GO:0044087 | 181 | 0.099 | |
| ribonucleotide metabolic process | GO:0009259 | 291 | 0.095 | |
| mitotic cytokinesis | GO:0000281 | 4 | 0.093 | |
| nucleoside monophosphate catabolic process | GO:0009125 | 59 | 0.092 | |
| nucleoside catabolic process | GO:0009164 | 206 | 0.090 | |
| protein deubiquitination | GO:0016579 | 19 | 0.088 | |
| purine nucleotide catabolic process | GO:0006195 | 211 | 0.088 | |
| regulation of organelle organization | GO:0033043 | 289 | 0.087 | |
| membrane fusion | GO:0061025 | 38 | 0.084 | |
| regulation of protein catabolic process | GO:0042176 | 108 | 0.084 | |
| positive regulation of sequence specific dna binding transcription factor activity | GO:0051091 | 68 | 0.082 | |
| exosomal secretion | GO:1990182 | 1 | 0.078 | |
| positive regulation of cellular catabolic process | GO:0031331 | 148 | 0.076 | |
| heterocycle catabolic process | GO:0046700 | 280 | 0.076 | |
| nucleoside triphosphate catabolic process | GO:0009143 | 205 | 0.074 | |
| regulation of chromosome organization | GO:0033044 | 83 | 0.074 | |
| purine nucleoside monophosphate metabolic process | GO:0009126 | 81 | 0.073 | |
| positive regulation of protein catabolic process | GO:0045732 | 60 | 0.072 | |
| multicellular organismal aging | GO:0010259 | 24 | 0.070 | Worm |
| cell division | GO:0051301 | 120 | 0.070 | |
| purine ribonucleoside monophosphate metabolic process | GO:0009167 | 80 | 0.069 | |
| glycosyl compound catabolic process | GO:1901658 | 206 | 0.066 | |
| glycosyl compound metabolic process | GO:1901657 | 246 | 0.063 | |
| copii coated vesicle budding | GO:0090114 | 2 | 0.063 | |
| spindle assembly involved in mitosis | GO:0090307 | 4 | 0.062 | |
| negative regulation of neuron apoptotic process | GO:0043524 | 92 | 0.062 | |
| mitochondrial fusion | GO:0008053 | 9 | 0.061 | |
| purine ribonucleotide catabolic process | GO:0009154 | 208 | 0.061 | |
| positive regulation of gtpase activity | GO:0043547 | 85 | 0.060 | |
| response to misfolded protein | GO:0051788 | 5 | 0.055 | |
| purine ribonucleoside monophosphate catabolic process | GO:0009169 | 57 | 0.055 | |
| chromatin organization | GO:0006325 | 206 | 0.055 | |
| ovulation cycle | GO:0042698 | 59 | 0.054 | |
| organophosphate catabolic process | GO:0046434 | 232 | 0.054 | |
| protein polymerization | GO:0051258 | 57 | 0.054 | |
| positive regulation of purine nucleotide catabolic process | GO:0033123 | 88 | 0.053 | |
| mitotic nuclear division | GO:0007067 | 48 | 0.053 | |
| regulation of actin filament polymerization | GO:0030833 | 38 | 0.052 | |
| positive regulation of protein modification process | GO:0031401 | 299 | 0.052 | |
| regulation of hydrolase activity | GO:0051336 | 246 | 0.049 | |
| nucleobase containing small molecule metabolic process | GO:0055086 | 352 | 0.049 | |
| regulation of feeding behavior | GO:0060259 | 3 | 0.049 | |
| mitotic sister chromatid segregation | GO:0000070 | 14 | 0.048 | |
| aromatic compound catabolic process | GO:0019439 | 286 | 0.048 | |
| positive regulation of proteasomal ubiquitin dependent protein catabolic process | GO:0032436 | 23 | 0.048 | |
| amine metabolic process | GO:0009308 | 45 | 0.047 | |
| neural tube formation | GO:0001841 | 108 | 0.045 | |
| positive regulation of proteolysis | GO:0045862 | 85 | 0.044 | |
| meiotic cell cycle process | GO:1903046 | 77 | 0.044 | |
| positive regulation of proteolysis involved in cellular protein catabolic process | GO:1903052 | 31 | 0.043 | |
| female sex differentiation | GO:0046660 | 84 | 0.043 | |
| inner cell mass cell proliferation | GO:0001833 | 15 | 0.042 | |
| regulation of proteasomal ubiquitin dependent protein catabolic process | GO:0032434 | 40 | 0.042 | |
| meiosis i | GO:0007127 | 60 | 0.042 | |
| sister chromatid segregation | GO:0000819 | 20 | 0.042 | |
| dna repair | GO:0006281 | 107 | 0.041 | |
| regulation of cellular protein catabolic process | GO:1903362 | 61 | 0.041 | |
| cellular response to misfolded protein | GO:0071218 | 5 | 0.040 | |
| positive regulation of cellular protein catabolic process | GO:1903364 | 34 | 0.040 | |
| negative regulation of protein metabolic process | GO:0051248 | 282 | 0.039 | |
| regulation of cell cycle process | GO:0010564 | 160 | 0.039 | |
| negative regulation of proteasomal ubiquitin dependent protein catabolic process | GO:0032435 | 15 | 0.039 | |
| microtubule cytoskeleton organization | GO:0000226 | 157 | 0.039 | |
| meiotic cell cycle | GO:0051321 | 122 | 0.039 | |
| regulation of cellular catabolic process | GO:0031329 | 242 | 0.038 | |
| synaptic transmission | GO:0007268 | 329 | 0.037 | |
| t cell activation | GO:0042110 | 289 | 0.037 | |
| trna wobble uridine modification | GO:0002098 | 2 | 0.037 | |
| positive regulation of protein phosphorylation | GO:0001934 | 242 | 0.037 | |
| t cell proliferation | GO:0042098 | 120 | 0.035 | |
| positive regulation of cellular amine metabolic process | GO:0033240 | 5 | 0.035 | |
| development of primary sexual characteristics | GO:0045137 | 143 | 0.035 | |
| small gtpase mediated signal transduction | GO:0007264 | 97 | 0.035 | |
| purine nucleoside monophosphate catabolic process | GO:0009128 | 58 | 0.035 | |
| inclusion body assembly | GO:0070841 | 3 | 0.034 | |
| regulation of cellular amino acid metabolic process | GO:0006521 | 5 | 0.034 | |
| cellular amino acid metabolic process | GO:0006520 | 103 | 0.033 | |
| regulation of proteasomal protein catabolic process | GO:0061136 | 46 | 0.033 | |
| cellular ketone metabolic process | GO:0042180 | 84 | 0.033 | |
| regulation of cellular amine metabolic process | GO:0033238 | 20 | 0.032 | |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 3 | 0.032 | |
| meiotic nuclear division | GO:0007126 | 115 | 0.032 | |
| connective tissue development | GO:0061448 | 179 | 0.032 | |
| translational initiation | GO:0006413 | 24 | 0.031 | |
| positive regulation of transcription elongation from rna polymerase ii promoter | GO:0032968 | 2 | 0.031 | |
| chromatin modification | GO:0016568 | 187 | 0.029 | |
| er associated ubiquitin dependent protein catabolic process | GO:0030433 | 10 | 0.028 | |
| double strand break repair | GO:0006302 | 48 | 0.028 | |
| regulation of cell division | GO:0051302 | 76 | 0.028 | |
| organic cyclic compound catabolic process | GO:1901361 | 295 | 0.028 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 66 | 0.028 | |
| negative regulation of proteolysis | GO:0045861 | 74 | 0.028 | |
| positive regulation of nucleoside metabolic process | GO:0045979 | 91 | 0.027 | |
| histone modification | GO:0016570 | 159 | 0.027 | |
| nucleotide metabolic process | GO:0009117 | 332 | 0.026 | |
| dna templated transcription elongation | GO:0006354 | 13 | 0.026 | |
| ribonucleoside triphosphate metabolic process | GO:0009199 | 220 | 0.026 | |
| peptidyl amino acid modification | GO:0018193 | 336 | 0.026 | |
| chromosome segregation | GO:0007059 | 48 | 0.025 | Fly |
| chromatin remodeling | GO:0006338 | 32 | 0.025 | |
| regulation of proteolysis | GO:0030162 | 164 | 0.024 | |
| regulation of protein ubiquitination | GO:0031396 | 52 | 0.023 | Fly |
| eye photoreceptor cell development | GO:0042462 | 31 | 0.023 | |
| organelle fusion | GO:0048284 | 28 | 0.023 | |
| regulation of protein modification by small protein conjugation or removal | GO:1903320 | 57 | 0.022 | Fly |
| gliogenesis | GO:0042063 | 141 | 0.022 | |
| organonitrogen compound catabolic process | GO:1901565 | 264 | 0.021 | |
| response to endoplasmic reticulum stress | GO:0034976 | 53 | 0.021 | |
| chromosome separation | GO:0051304 | 14 | 0.021 | |
| stem cell differentiation | GO:0048863 | 268 | 0.021 | |
| sperm egg recognition | GO:0035036 | 37 | 0.020 | |
| cellular amine metabolic process | GO:0044106 | 44 | 0.020 | |
| positive regulation of protein kinase activity | GO:0045860 | 144 | 0.020 | |
| negative regulation of cellular protein catabolic process | GO:1903363 | 22 | 0.020 | |
| male gamete generation | GO:0048232 | 285 | 0.020 | Worm |
| guanosine containing compound catabolic process | GO:1901069 | 144 | 0.020 | |
| cartilage development | GO:0051216 | 140 | 0.019 | |
| translesion synthesis | GO:0019985 | 1 | 0.019 | |
| transcription elongation from rna polymerase ii promoter | GO:0006368 | 9 | 0.019 | |
| regulation of protein deubiquitination | GO:0090085 | 1 | 0.019 | |
| lipid localization | GO:0010876 | 126 | 0.019 | |
| exocytosis | GO:0006887 | 121 | 0.019 | |
| regulation of mitotic sister chromatid segregation | GO:0033047 | 12 | 0.019 | |
| ras protein signal transduction | GO:0007265 | 77 | 0.018 | |
| regulation of proteolysis involved in cellular protein catabolic process | GO:1903050 | 56 | 0.018 | |
| response to peptide hormone | GO:0043434 | 127 | 0.018 | |
| protein maturation | GO:0051604 | 176 | 0.018 | |
| protein processing | GO:0016485 | 163 | 0.018 | |
| regulation of translation | GO:0006417 | 71 | 0.017 | |
| positive regulation of endopeptidase activity | GO:0010950 | 43 | 0.017 | |
| regulation of nuclear division | GO:0051783 | 56 | 0.017 | |
| cell adhesion | GO:0007155 | 329 | 0.017 | |
| negative regulation of intracellular signal transduction | GO:1902532 | 167 | 0.017 | |
| camera type eye development | GO:0043010 | 266 | 0.017 | |
| fertilization | GO:0009566 | 127 | 0.017 | |
| lymphocyte differentiation | GO:0030098 | 242 | 0.017 | |
| mapk cascade | GO:0000165 | 281 | 0.016 | |
| negative regulation of protein catabolic process | GO:0042177 | 36 | 0.016 | |
| regulation of actin cytoskeleton organization | GO:0032956 | 84 | 0.016 | |
| positive regulation of organelle organization | GO:0010638 | 128 | 0.016 | |
| transmembrane receptor protein tyrosine kinase signaling pathway | GO:0007169 | 247 | 0.016 | |
| female gonad development | GO:0008585 | 71 | 0.016 | |
| dna recombination | GO:0006310 | 92 | 0.016 | |
| protein modification by small protein conjugation or removal | GO:0070647 | 207 | 0.016 | Fly |
| regulation of transferase activity | GO:0051338 | 263 | 0.016 | |
| regulation of cytoskeleton organization | GO:0051493 | 122 | 0.016 | |
| non recombinational repair | GO:0000726 | 10 | 0.016 | |
| protein acylation | GO:0043543 | 64 | 0.016 | |
| protein secretion | GO:0009306 | 111 | 0.015 | |
| covalent chromatin modification | GO:0016569 | 163 | 0.015 | |
| intrinsic apoptotic signaling pathway | GO:0097193 | 132 | 0.015 | |
| calcium ion transport | GO:0006816 | 159 | 0.015 | |
| regulation of membrane potential | GO:0042391 | 192 | 0.015 | |
| regulation of protein maturation | GO:1903317 | 96 | 0.015 | |
| divalent inorganic cation transport | GO:0072511 | 178 | 0.015 | |
| spermatogenesis | GO:0007283 | 284 | 0.015 | Worm |
| cytokine production | GO:0001816 | 319 | 0.015 | |
| development of primary female sexual characteristics | GO:0046545 | 73 | 0.015 | |
| regulation of receptor activity | GO:0010469 | 41 | 0.015 | |
| blood vessel morphogenesis | GO:0048514 | 285 | 0.015 | |
| positive regulation of peptidase activity | GO:0010952 | 49 | 0.015 | |
| sensory organ morphogenesis | GO:0090596 | 242 | 0.014 | |
| regulation of inflammatory response | GO:0050727 | 147 | 0.014 | |
| negative regulation of proteolysis involved in cellular protein catabolic process | GO:1903051 | 22 | 0.014 | |
| catecholamine uptake involved in synaptic transmission | GO:0051934 | 4 | 0.014 | |
| positive regulation of purine nucleotide metabolic process | GO:1900544 | 114 | 0.014 | |
| oocyte construction | GO:0007308 | 2 | 0.014 | |
| spermatid differentiation | GO:0048515 | 115 | 0.014 | |
| positive regulation of nucleotide metabolic process | GO:0045981 | 114 | 0.014 | |
| leukocyte differentiation | GO:0002521 | 342 | 0.014 | |
| transmembrane receptor protein serine threonine kinase signaling pathway | GO:0007178 | 194 | 0.014 | |
| regulation of actin filament based process | GO:0032970 | 99 | 0.014 | |
| rhythmic process | GO:0048511 | 174 | 0.014 | |
| purine ribonucleoside catabolic process | GO:0046130 | 205 | 0.013 | |
| trna metabolic process | GO:0006399 | 11 | 0.013 | |
| nucleoside phosphate metabolic process | GO:0006753 | 338 | 0.013 | |
| regulation of mitotic cell cycle | GO:0007346 | 126 | 0.013 | |
| mitotic sister chromatid separation | GO:0051306 | 9 | 0.013 | |
| regulation of sequence specific dna binding transcription factor activity | GO:0051090 | 106 | 0.013 | |
| oocyte axis specification | GO:0007309 | 2 | 0.013 | |
| cytokinetic process | GO:0032506 | 2 | 0.013 | |
| organelle membrane fusion | GO:0090174 | 1 | 0.013 | |
| skeletal system development | GO:0001501 | 356 | 0.013 | |
| response to organonitrogen compound | GO:0010243 | 246 | 0.013 | |
| ossification | GO:0001503 | 216 | 0.013 | |
| cellular divalent inorganic cation homeostasis | GO:0072503 | 127 | 0.013 | |
| endomembrane system organization | GO:0010256 | 147 | 0.013 | |
| cellular response to organonitrogen compound | GO:0071417 | 145 | 0.013 | |
| positive regulation of transferase activity | GO:0051347 | 167 | 0.012 | |
| ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway | GO:0043162 | 3 | 0.012 | |
| peptidyl serine phosphorylation | GO:0018105 | 74 | 0.012 | |
| ameboidal type cell migration | GO:0001667 | 128 | 0.012 | |
| myeloid cell differentiation | GO:0030099 | 233 | 0.012 | |
| actin filament organization | GO:0007015 | 113 | 0.012 | |
| positive regulation of growth hormone receptor signaling pathway | GO:0060399 | 3 | 0.012 | |
| leukocyte migration | GO:0050900 | 124 | 0.012 | |
| endocytosis | GO:0006897 | 168 | 0.012 | |
| alpha beta t cell activation | GO:0046631 | 91 | 0.012 | |
| metaphase anaphase transition of mitotic cell cycle | GO:0007091 | 9 | 0.012 | |
| extracellular matrix organization | GO:0030198 | 147 | 0.012 | |
| norepinephrine secretion | GO:0048243 | 2 | 0.012 | |
| maintenance of location | GO:0051235 | 89 | 0.011 | |
| oogenesis | GO:0048477 | 56 | 0.011 | |
| negative regulation of translational initiation | GO:0045947 | 4 | 0.011 | |
| cellular homeostasis | GO:0019725 | 240 | 0.011 | |
| negative regulation of neuron death | GO:1901215 | 98 | 0.011 | |
| response to transforming growth factor beta | GO:0071559 | 88 | 0.011 | |
| embryonic organ morphogenesis | GO:0048562 | 276 | 0.011 | |
| extracellular structure organization | GO:0043062 | 148 | 0.011 | |
| g protein coupled receptor signaling pathway | GO:0007186 | 243 | 0.011 | |
| organic hydroxy compound metabolic process | GO:1901615 | 203 | 0.011 | |
| regulation of translational elongation | GO:0006448 | 4 | 0.011 | |
| negative regulation of protein maturation | GO:1903318 | 79 | 0.011 | |
| mature dendritic cell differentiation | GO:0097029 | 3 | 0.011 | |
| t cell differentiation in thymus | GO:0033077 | 77 | 0.011 | |
| guanosine containing compound metabolic process | GO:1901068 | 144 | 0.011 | |
| maternal determination of anterior posterior axis embryo | GO:0008358 | 2 | 0.011 | |
| regulation of cell activation | GO:0050865 | 289 | 0.011 | |
| regulation of cell adhesion | GO:0030155 | 154 | 0.010 | |
| organelle localization | GO:0051640 | 179 | 0.010 | |
| astrocyte development | GO:0014002 | 12 | 0.010 | |
| negative regulation of protein processing | GO:0010955 | 79 | 0.010 | |
| response to inorganic substance | GO:0010035 | 96 | 0.010 | |
| protein neddylation | GO:0045116 | 1 | 0.010 | |