IMP: Integrative Multi-species Prediction

Mus musculus

84 known processes

Raf1

v-raf-leukemia viral oncogene 1

(Aliases: D830050J10Rik,6430402F14Rik,BB129353,c-Raf,Craf1,v-Raf,Raf-1,MGC102375,AA990557)

Entrez: 110157
Ensembl: ENSMUSG00000000441
UniProtKB: Q99N57

Process Predictions
Disease Predictions

Raf1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
ras protein signal transduction	GO:0007265	77	0.937	Worm Fly
dna metabolic process	GO:0006259	303	0.877
small gtpase mediated signal transduction	GO:0007264	97	0.838	Worm Fly
stem cell differentiation	GO:0048863	268	0.705
regulation of ras protein signal transduction	GO:0046578	114	0.692	Fly
oocyte axis specification	GO:0007309	2	0.627
regulation of autophagy	GO:0010506	30	0.568	Fly
regulation of cellular ketone metabolic process	GO:0010565	66	0.567
response to radiation	GO:0009314	165	0.532	Mouse
regulation of protein kinase activity	GO:0045859	232	0.511	Rat
regulation of cell cycle	GO:0051726	281	0.508	Fly
regulation of apoptotic signaling pathway	GO:2001233	197	0.499
oocyte construction	GO:0007308	2	0.489
macroautophagy	GO:0016236	21	0.480	Fly
negative regulation of cell proliferation	GO:0008285	296	0.461	Human
mitotic cell cycle	GO:0000278	195	0.446
synaptic transmission	GO:0007268	329	0.437	Mouse
regulation of mitotic cell cycle	GO:0007346	126	0.434
autophagy	GO:0006914	45	0.434	Fly
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.433	Mouse Fly
regulation of cell cycle process	GO:0010564	160	0.432
peptidyl amino acid modification	GO:0018193	336	0.424	Human
photoreceptor cell morphogenesis	GO:0008594	3	0.398
apoptotic signaling pathway	GO:0097190	306	0.391
cytoplasmic transport	GO:0016482	234	0.386
regulation of protein serine threonine kinase activity	GO:0071900	157	0.379	Rat
learning or memory	GO:0007611	148	0.374	Mouse
gliogenesis	GO:0042063	141	0.365
cellular ketone metabolic process	GO:0042180	84	0.358
oocyte differentiation	GO:0009994	35	0.356
regulation of mapk cascade	GO:0043408	248	0.348	Mouse Rat Fly
protein modification by small protein conjugation	GO:0032446	187	0.346
neuron death	GO:0070997	154	0.334	Mouse
dna replication	GO:0006260	52	0.329
mitotic cell cycle process	GO:1903047	159	0.328
cognition	GO:0050890	149	0.327	Mouse
negative regulation of cell cycle	GO:0045786	123	0.326
development of primary sexual characteristics	GO:0045137	143	0.324
cell cycle checkpoint	GO:0000075	47	0.322
regulation of cellular response to stress	GO:0080135	159	0.321	Fly
nucleoside triphosphate metabolic process	GO:0009141	230	0.320
germ cell development	GO:0007281	185	0.318	Fly
cell fate commitment	GO:0045165	210	0.318	Worm
muscle cell differentiation	GO:0042692	261	0.316
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.311
photoreceptor cell differentiation	GO:0046530	52	0.311	Fly
positive regulation of mapk cascade	GO:0043410	170	0.308	Mouse Rat Fly
developmental maturation	GO:0021700	193	0.301
regulation of cellular catabolic process	GO:0031329	242	0.301	Fly
cell fate specification	GO:0001708	72	0.300	Worm
cellular response to dna damage stimulus	GO:0006974	207	0.299
associative learning	GO:0008306	61	0.298	Mouse
carbon catabolite activation of transcription	GO:0045991	4	0.295
positive regulation of cell development	GO:0010720	237	0.290	Mouse Fly
intracellular protein transport	GO:0006886	204	0.288
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.286
erk1 and erk2 cascade	GO:0070371	77	0.282	Mouse Fly
protein ubiquitination	GO:0016567	171	0.270
protein modification by small protein conjugation or removal	GO:0070647	207	0.270
regulation of protein localization	GO:0032880	231	0.265
response to growth factor	GO:0070848	198	0.258
positive regulation of ras protein signal transduction	GO:0046579	13	0.258	Fly
positive regulation of rac protein signal transduction	GO:0035022	1	0.251
response to ionizing radiation	GO:0010212	42	0.250
positive regulation of nervous system development	GO:0051962	221	0.250	Fly
negative regulation of macroautophagy	GO:0016242	5	0.238	Fly
cellular response to cytokine stimulus	GO:0071345	189	0.236
regulation of neuron death	GO:1901214	134	0.234	Mouse
cellular amine metabolic process	GO:0044106	44	0.232
protein autophosphorylation	GO:0046777	61	0.232	Fly
cellular response to starvation	GO:0009267	57	0.230	Fly
cellular response to growth factor stimulus	GO:0071363	197	0.230
respiratory tube development	GO:0030323	167	0.229
regulation of synaptic plasticity	GO:0048167	87	0.229	Mouse
positive regulation of protein kinase activity	GO:0045860	144	0.227	Rat
respiratory system development	GO:0060541	190	0.227
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.223
positive regulation of transcription by galactose	GO:0000411	1	0.222
positive regulation of cellular amine metabolic process	GO:0033240	5	0.220
regulation of map kinase activity	GO:0043405	120	0.218	Rat
regulation of cellular amine metabolic process	GO:0033238	20	0.216
positive regulation of rap gtpase activity	GO:0032854	3	0.215
amine metabolic process	GO:0009308	45	0.214
nucleoside phosphate metabolic process	GO:0006753	338	0.212
negative regulation of neuron death	GO:1901215	98	0.210	Mouse
digestive system development	GO:0055123	200	0.209	Fly
ribonucleotide metabolic process	GO:0009259	291	0.209
regulation of cell motility	GO:2000145	236	0.208	Mouse
purine ribonucleotide metabolic process	GO:0009150	290	0.207
purine ribonucleoside catabolic process	GO:0046130	205	0.203
homeostasis of number of cells	GO:0048872	210	0.203
dna repair	GO:0006281	107	0.202
regulation of erk1 and erk2 cascade	GO:0070372	71	0.200	Mouse Fly
positive regulation of cellular catabolic process	GO:0031331	148	0.200
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.200
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.199	Rat
regulation of actin filament based process	GO:0032970	99	0.198	Mouse
digestive tract development	GO:0048565	190	0.198	Fly
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.197
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.196
purine containing compound metabolic process	GO:0072521	311	0.195
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.194
cell type specific apoptotic process	GO:0097285	268	0.193	Mouse
gonad development	GO:0008406	141	0.193
actin cytoskeleton organization	GO:0030036	220	0.190	Mouse
positive regulation of protein modification process	GO:0031401	299	0.190	Human Rat
positive regulation of kinase activity	GO:0033674	155	0.188	Rat
negative regulation of neuron apoptotic process	GO:0043524	92	0.183	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.183	Human Rat
lung development	GO:0030324	164	0.183
negative regulation of mitotic cell cycle	GO:0045930	58	0.181
stem cell development	GO:0048864	219	0.177
regulation of kinase activity	GO:0043549	249	0.175	Rat
nucleocytoplasmic transport	GO:0006913	139	0.175
organelle fission	GO:0048285	170	0.173
regulation of hydrolase activity	GO:0051336	246	0.171
meiotic cell cycle	GO:0051321	122	0.171
epithelial cell proliferation	GO:0050673	174	0.170
positive regulation of hydrolase activity	GO:0051345	148	0.169
mapk cascade	GO:0000165	281	0.168	Mouse Rat Fly
cellular amino acid metabolic process	GO:0006520	103	0.167
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.167
activation of adenylate cyclase activity	GO:0007190	4	0.167
protein localization to organelle	GO:0033365	185	0.165
protein import into nucleus	GO:0006606	95	0.165
skin development	GO:0043588	220	0.163
multicellular organism growth	GO:0035264	161	0.163	Fly
epithelial tube morphogenesis	GO:0060562	303	0.163
gtp catabolic process	GO:0006184	143	0.160
rac protein signal transduction	GO:0016601	13	0.155
regulation of purine nucleotide metabolic process	GO:1900542	169	0.155
nucleobase containing small molecule metabolic process	GO:0055086	352	0.155
localization within membrane	GO:0051668	4	0.153
regulation of nucleoside metabolic process	GO:0009118	130	0.153
regulation of neuron differentiation	GO:0045664	281	0.151	Fly
oocyte development	GO:0048599	33	0.150
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.150
female gamete generation	GO:0007292	74	0.150	Fly
regulation of organelle organization	GO:0033043	289	0.149	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.149
macromolecule catabolic process	GO:0009057	281	0.148
ribonucleoside metabolic process	GO:0009119	245	0.147
negative regulation of intracellular signal transduction	GO:1902532	167	0.144
negative regulation of phosphorylation	GO:0042326	166	0.143
protein targeting	GO:0006605	143	0.141
organophosphate biosynthetic process	GO:0090407	122	0.141
intrinsic apoptotic signaling pathway	GO:0097193	132	0.140
peptidyl tyrosine phosphorylation	GO:0018108	143	0.138
regulation of cell migration	GO:0030334	219	0.137	Mouse
regulation of transcription by galactose	GO:0000409	1	0.137
purine nucleoside metabolic process	GO:0042278	241	0.136
positive regulation of map kinase activity	GO:0043406	84	0.133	Rat
wound healing	GO:0042060	157	0.131
regulation of cell projection organization	GO:0031344	206	0.131
wnt signaling pathway	GO:0016055	188	0.130
cellular protein catabolic process	GO:0044257	155	0.128
ubiquitin dependent protein catabolic process	GO:0006511	129	0.128
guanosine containing compound metabolic process	GO:1901068	144	0.128
positive regulation of gtpase activity	GO:0043547	85	0.126
nuclear division	GO:0000280	158	0.125
regulation of secretion	GO:0051046	274	0.123	Mouse
tor signaling	GO:0031929	21	0.122
multi multicellular organism process	GO:0044706	109	0.122
regulation of ras gtpase activity	GO:0032318	88	0.122
stem cell proliferation	GO:0072089	117	0.121
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.121
epidermis development	GO:0008544	187	0.121
visual behavior	GO:0007632	45	0.120	Mouse
positive regulation of transferase activity	GO:0051347	167	0.120	Rat
neuron apoptotic process	GO:0051402	142	0.119	Mouse
stem cell maintenance	GO:0019827	130	0.119
protein oligomerization	GO:0051259	67	0.118
regulation of body fluid levels	GO:0050878	162	0.118
regulation of cell cycle phase transition	GO:1901987	77	0.117
nucleotide biosynthetic process	GO:0009165	78	0.116
positive regulation of cell death	GO:0010942	224	0.115
positive regulation of ras gtpase activity	GO:0032320	65	0.115
positive regulation of nucleotide metabolic process	GO:0045981	114	0.115
leukocyte differentiation	GO:0002521	342	0.114	Mouse
organonitrogen compound catabolic process	GO:1901565	264	0.114
g protein coupled receptor signaling pathway	GO:0007186	243	0.113
peptidyl serine modification	GO:0018209	83	0.113	Human
organonitrogen compound biosynthetic process	GO:1901566	192	0.112
regulation of neuron apoptotic process	GO:0043523	122	0.112	Mouse
negative regulation of autophagy	GO:0010507	9	0.111	Fly
skeletal muscle organ development	GO:0060538	163	0.111
dephosphorylation	GO:0016311	129	0.111
extrinsic apoptotic signaling pathway	GO:0097191	126	0.109
aromatic compound catabolic process	GO:0019439	286	0.108
protein import	GO:0017038	101	0.108
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.106
protein catabolic process	GO:0030163	221	0.106
positive regulation of nucleotide catabolic process	GO:0030813	88	0.106
purine nucleoside catabolic process	GO:0006152	205	0.105
cell cycle arrest	GO:0007050	37	0.105
regulation of nucleotide metabolic process	GO:0006140	169	0.105
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.104
regulation of exocytosis	GO:0017157	61	0.103	Mouse
cell maturation	GO:0048469	127	0.103
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.103
purine nucleotide metabolic process	GO:0006163	302	0.103
positive regulation of nucleoside metabolic process	GO:0045979	91	0.103
negative regulation of cellular catabolic process	GO:0031330	47	0.102	Fly
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.100
cellular lipid metabolic process	GO:0044255	323	0.100
dna integrity checkpoint	GO:0031570	28	0.100
myeloid cell differentiation	GO:0030099	233	0.099
regulation of nucleotide catabolic process	GO:0030811	122	0.099
guanosine containing compound catabolic process	GO:1901069	144	0.098
gastrulation	GO:0007369	116	0.098	Fly
cardiac muscle cell contraction	GO:0086003	7	0.098
carbon catabolite regulation of transcription	GO:0045990	4	0.097
peptidyl tyrosine modification	GO:0018212	145	0.096
establishment of protein localization to organelle	GO:0072594	118	0.096
action potential	GO:0001508	78	0.096
regulation of cellular amino acid metabolic process	GO:0006521	5	0.096
regulation of macroautophagy	GO:0016241	12	0.096	Fly
nucleotide catabolic process	GO:0009166	217	0.095
neuron migration	GO:0001764	122	0.095
muscle system process	GO:0003012	141	0.094
positive regulation of neuron differentiation	GO:0045666	141	0.094	Fly
meiotic nuclear division	GO:0007126	115	0.094
rho protein signal transduction	GO:0007266	32	0.093
regulation of protein transport	GO:0051223	163	0.092
ribonucleoside catabolic process	GO:0042454	206	0.092
oogenesis	GO:0048477	56	0.091	Fly
positive regulation of apoptotic process	GO:0043065	217	0.091
keratinocyte differentiation	GO:0030216	48	0.090
immune response regulating signaling pathway	GO:0002764	125	0.089
rap protein signal transduction	GO:0032486	3	0.089
negative regulation of phosphate metabolic process	GO:0045936	184	0.089
purine containing compound biosynthetic process	GO:0072522	70	0.088
cell aging	GO:0007569	35	0.088
negative regulation of fibroblast migration	GO:0010764	2	0.088	Mouse
regulation of cellular component biogenesis	GO:0044087	181	0.088	Human Mouse
negative regulation of cell migration	GO:0030336	59	0.087	Mouse
nuclear import	GO:0051170	95	0.087
negative regulation of cell cycle phase transition	GO:1901988	48	0.087
heterocycle catabolic process	GO:0046700	280	0.087
nucleoside metabolic process	GO:0009116	246	0.087
nucleoside phosphate biosynthetic process	GO:1901293	79	0.086
cellular senescence	GO:0090398	11	0.086
negative regulation of protein phosphorylation	GO:0001933	126	0.086
cyclic nucleotide biosynthetic process	GO:0009190	44	0.085
regulation of system process	GO:0044057	200	0.085
regulation of cell size	GO:0008361	72	0.085
activation of immune response	GO:0002253	138	0.084
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.083	Mouse
axonogenesis	GO:0007409	274	0.083
negative regulation of cell motility	GO:2000146	61	0.083	Mouse
regulation of chromatin modification	GO:1903308	57	0.083
glycosyl compound catabolic process	GO:1901658	206	0.082
ribose phosphate biosynthetic process	GO:0046390	59	0.081
macromolecule methylation	GO:0043414	120	0.080
nucleotide metabolic process	GO:0009117	332	0.080
multi organism behavior	GO:0051705	62	0.080
endocytosis	GO:0006897	168	0.080
positive regulation of cell migration	GO:0030335	109	0.079
microtubule based process	GO:0007017	236	0.079
purine ribonucleotide biosynthetic process	GO:0009152	59	0.079
negative regulation of immune system process	GO:0002683	209	0.079
regulation of rac protein signal transduction	GO:0035020	19	0.079
regulation of epithelial cell proliferation	GO:0050678	141	0.078
transmission of nerve impulse	GO:0019226	76	0.077
cellular response to lipid	GO:0071396	145	0.077
microtubule cytoskeleton organization	GO:0000226	157	0.077
inflammatory response	GO:0006954	244	0.077
multicellular organismal homeostasis	GO:0048871	164	0.077
glial cell differentiation	GO:0010001	131	0.076
regulation of establishment of protein localization	GO:0070201	181	0.075
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.075
nucleoside catabolic process	GO:0009164	206	0.075
response to organic cyclic compound	GO:0014070	198	0.075
striated muscle tissue development	GO:0014706	293	0.075
regulation of muscle tissue development	GO:1901861	97	0.074
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.073
muscle tissue development	GO:0060537	308	0.073
digestive tract morphogenesis	GO:0048546	147	0.072	Fly
regulation of myelination	GO:0031641	20	0.072
carbohydrate derivative biosynthetic process	GO:1901137	183	0.072
ribonucleotide biosynthetic process	GO:0009260	59	0.072
cell growth	GO:0016049	130	0.071
regulation of purine nucleotide catabolic process	GO:0033121	122	0.071
organic cyclic compound catabolic process	GO:1901361	295	0.071
regulation of membrane potential	GO:0042391	192	0.070
cerebral cortex development	GO:0021987	86	0.070
regulation of cell activation	GO:0050865	289	0.069
positive regulation of cell motility	GO:2000147	116	0.069
multicellular organismal reproductive behavior	GO:0033057	23	0.069
cytokine production	GO:0001816	319	0.069
skeletal system development	GO:0001501	356	0.069
reproductive behavior	GO:0019098	32	0.069
maintenance of location	GO:0051235	89	0.069
organelle localization	GO:0051640	179	0.069	Mouse
response to starvation	GO:0042594	65	0.069	Fly
regulation of chromosome organization	GO:0033044	83	0.069
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.068
negative regulation of cell cycle process	GO:0010948	69	0.068
mitochondrion organization	GO:0007005	134	0.068
purine nucleotide catabolic process	GO:0006195	211	0.068
embryonic placenta development	GO:0001892	98	0.068
regulation of wound healing	GO:0061041	40	0.067
exocytosis	GO:0006887	121	0.067	Mouse
multicellular organismal signaling	GO:0035637	91	0.067
negative regulation of cellular amine metabolic process	GO:0033239	1	0.067
regionalization	GO:0003002	337	0.067	Fly
myeloid leukocyte differentiation	GO:0002573	119	0.067
regulation of dna replication	GO:0006275	17	0.066
memory	GO:0007613	58	0.066
regulation of gtp catabolic process	GO:0033124	113	0.065
mitotic nuclear division	GO:0007067	48	0.065
positive regulation of leukocyte differentiation	GO:1902107	86	0.065
learning	GO:0007612	98	0.065	Mouse
cellular response to nutrient levels	GO:0031669	64	0.064	Fly
single organism nuclear import	GO:1902593	95	0.064
immune effector process	GO:0002252	321	0.064
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	54	0.064
regulation of actin cytoskeleton organization	GO:0032956	84	0.062	Mouse
glycosyl compound metabolic process	GO:1901657	246	0.062
regulation of anatomical structure size	GO:0090066	178	0.061
regulation of transferase activity	GO:0051338	263	0.061	Rat
myelination	GO:0042552	74	0.061
purine ribonucleotide catabolic process	GO:0009154	208	0.061
immune response activating signal transduction	GO:0002757	116	0.061
nucleoside triphosphate catabolic process	GO:0009143	205	0.060
lung morphogenesis	GO:0060425	50	0.060
neuronal action potential	GO:0019228	54	0.060
compound eye development	GO:0048749	1	0.060
regulation of defense response	GO:0031347	233	0.059
response to light stimulus	GO:0009416	135	0.059	Mouse
nuclear transport	GO:0051169	139	0.059
ribose phosphate metabolic process	GO:0019693	291	0.059
multi organism reproductive behavior	GO:0044705	29	0.058
establishment of organelle localization	GO:0051656	122	0.058	Mouse
establishment or maintenance of bipolar cell polarity	GO:0061245	21	0.057
regulation of synaptic transmission gabaergic	GO:0032228	17	0.057
chromatin organization	GO:0006325	206	0.057
epidermal growth factor receptor signaling pathway	GO:0007173	28	0.056	Fly
dna damage checkpoint	GO:0000077	26	0.056
cellular macromolecule catabolic process	GO:0044265	206	0.056
stem cell fate commitment	GO:0048865	5	0.055
male gamete generation	GO:0048232	285	0.055	Fly
histone modification	GO:0016570	159	0.055
photoreceptor cell development	GO:0042461	40	0.055
hair follicle development	GO:0001942	85	0.055
appendage development	GO:0048736	166	0.055	Fly
skeletal system morphogenesis	GO:0048705	203	0.054
negative regulation of phosphorus metabolic process	GO:0010563	184	0.054
negative regulation of mapk cascade	GO:0043409	65	0.054
response to osmotic stress	GO:0006970	21	0.054
adult behavior	GO:0030534	135	0.054
actin filament based movement	GO:0030048	23	0.054
response to extracellular stimulus	GO:0009991	127	0.054	Fly
proteasomal protein catabolic process	GO:0010498	98	0.053
rhythmic process	GO:0048511	174	0.053
mitotic cell cycle checkpoint	GO:0007093	31	0.053
regulation of intracellular protein transport	GO:0033157	82	0.053
spermatogenesis	GO:0007283	284	0.053	Fly
cyclic nucleotide metabolic process	GO:0009187	59	0.053
protein localization to nucleus	GO:0034504	121	0.053
establishment or maintenance of cell polarity	GO:0007163	86	0.053	Fly
pole plasm assembly	GO:0007315	2	0.052
chemotaxis	GO:0006935	247	0.052
dna alkylation	GO:0006305	43	0.052
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.052
gtp metabolic process	GO:0046039	144	0.052
urogenital system development	GO:0001655	261	0.052
nucleoside phosphate catabolic process	GO:1901292	222	0.052
negative regulation of molecular function	GO:0044092	258	0.052
regulation of leukocyte differentiation	GO:1902105	159	0.052
morphogenesis of a branching structure	GO:0001763	203	0.052
response to lipopolysaccharide	GO:0032496	128	0.051
negative regulation of epithelial cell proliferation	GO:0050680	64	0.051
purine ribonucleoside metabolic process	GO:0046128	241	0.051
regulation of wnt signaling pathway	GO:0030111	123	0.051
methylation	GO:0032259	134	0.051
carbohydrate derivative catabolic process	GO:1901136	231	0.051
positive regulation of nitric oxide synthase activity	GO:0051000	2	0.051
regulation of response to wounding	GO:1903034	189	0.051
cellular response to abiotic stimulus	GO:0071214	56	0.051
body morphogenesis	GO:0010171	45	0.051
response to oxidative stress	GO:0006979	123	0.051
tissue homeostasis	GO:0001894	115	0.051
t cell activation	GO:0042110	289	0.050	Mouse
endomembrane system organization	GO:0010256	147	0.050
ameboidal type cell migration	GO:0001667	128	0.050	Mouse Fly
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.050
epithelial tube formation	GO:0072175	130	0.050
positive regulation of dna biosynthetic process	GO:2000573	4	0.050
connective tissue development	GO:0061448	179	0.050
regulation of intracellular transport	GO:0032386	159	0.050
cell division	GO:0051301	120	0.050
cell fate determination	GO:0001709	32	0.050
cellular nitrogen compound catabolic process	GO:0044270	280	0.049
positive regulation of cellular component biogenesis	GO:0044089	94	0.049	Mouse
regulation of protein stability	GO:0031647	52	0.049
carbohydrate metabolic process	GO:0005975	230	0.049
muscle cell development	GO:0055001	133	0.048
anatomical structure homeostasis	GO:0060249	145	0.048
negative regulation of synaptic vesicle exocytosis	GO:2000301	3	0.048	Mouse
modification dependent protein catabolic process	GO:0019941	133	0.048
cardiac muscle contraction	GO:0060048	32	0.047
positive regulation of cell projection organization	GO:0031346	95	0.047
purine containing compound catabolic process	GO:0072523	213	0.046
genitalia development	GO:0048806	37	0.046
regulation of cell division	GO:0051302	76	0.046
response to temperature stimulus	GO:0009266	55	0.045
negative regulation of nervous system development	GO:0051961	156	0.045
negative regulation of organ growth	GO:0046621	17	0.045
forebrain development	GO:0030900	302	0.045
blood vessel morphogenesis	GO:0048514	285	0.044
circadian rhythm	GO:0007623	114	0.044
regulation of protein targeting	GO:1903533	61	0.044
modification dependent macromolecule catabolic process	GO:0043632	133	0.044
regulation of neurotransmitter levels	GO:0001505	87	0.044	Mouse
embryonic organ morphogenesis	GO:0048562	276	0.044
regulation of cellular component size	GO:0032535	121	0.043
meiotic cell cycle process	GO:1903046	77	0.043
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.043
covalent chromatin modification	GO:0016569	163	0.042
kidney development	GO:0001822	213	0.042
establishment or maintenance of apical basal cell polarity	GO:0035088	21	0.042
regulation of myeloid cell differentiation	GO:0045637	96	0.042
regulation of cytokine production	GO:0001817	266	0.042
establishment of synaptic vesicle localization	GO:0097480	57	0.042	Mouse
axon ensheathment	GO:0008366	76	0.042
visual learning	GO:0008542	44	0.042	Mouse
positive regulation of gtp catabolic process	GO:0033126	85	0.042
regulation of proteasomal protein catabolic process	GO:0061136	46	0.042
negative regulation of hydrolase activity	GO:0051346	71	0.041
pallium development	GO:0021543	120	0.041
morphogenesis of a branching epithelium	GO:0061138	193	0.041
b cell activation	GO:0042113	161	0.041
negative regulation of dna replication	GO:0008156	4	0.041
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.040
response to organonitrogen compound	GO:0010243	246	0.040
positive regulation of nucleocytoplasmic transport	GO:0046824	30	0.040
positive regulation of organelle organization	GO:0010638	128	0.040	Mouse
cellular component assembly involved in morphogenesis	GO:0010927	139	0.040
chromatin modification	GO:0016568	187	0.040
regulation of purine nucleotide biosynthetic process	GO:1900371	34	0.039
camera type eye development	GO:0043010	266	0.039
stress activated protein kinase signaling cascade	GO:0031098	81	0.039
vesicle localization	GO:0051648	86	0.039	Mouse
regulation of protein catabolic process	GO:0042176	108	0.039
regulation of cellular protein catabolic process	GO:1903362	61	0.039
social behavior	GO:0035176	21	0.039
lymphocyte differentiation	GO:0030098	242	0.038	Mouse
developmental growth involved in morphogenesis	GO:0060560	138	0.038
regulation of long term neuronal synaptic plasticity	GO:0048169	19	0.038
cyclic purine nucleotide metabolic process	GO:0052652	43	0.038
erbb signaling pathway	GO:0038127	32	0.038	Fly
synaptic transmission gabaergic	GO:0051932	19	0.038
meiosis i	GO:0007127	60	0.038
ensheathment of neurons	GO:0007272	76	0.037
membrane organization	GO:0061024	245	0.037
regulation of nucleocytoplasmic transport	GO:0046822	73	0.037
ossification	GO:0001503	216	0.037
regulation of cytoskeleton organization	GO:0051493	122	0.037	Mouse
negative regulation of wnt signaling pathway	GO:0030178	73	0.037
epithelial cell development	GO:0002064	159	0.037	Fly
generation of precursor metabolites and energy	GO:0006091	103	0.037
dna modification	GO:0006304	50	0.037
negative regulation of muscle tissue development	GO:1901862	20	0.036
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.036
response to acid chemical	GO:0001101	111	0.036
embryonic epithelial tube formation	GO:0001838	130	0.036
leukocyte mediated immunity	GO:0002443	174	0.036
regulation of epidermal cell differentiation	GO:0045604	21	0.036
positive regulation of intracellular transport	GO:0032388	70	0.035
regulation of secretion by cell	GO:1903530	249	0.035	Mouse
positive regulation of cyclic nucleotide biosynthetic process	GO:0030804	24	0.035
response to heat	GO:0009408	27	0.035
negative regulation of growth	GO:0045926	99	0.035
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.035
cardiocyte differentiation	GO:0035051	87	0.035
regulation of t cell proliferation	GO:0042129	92	0.035
negative regulation of cell development	GO:0010721	169	0.034
posttranscriptional regulation of gene expression	GO:0010608	155	0.034
cellular ion homeostasis	GO:0006873	165	0.034
ribonucleotide catabolic process	GO:0009261	208	0.034
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.034
negative regulation of organelle organization	GO:0010639	90	0.034
cardiac muscle tissue development	GO:0048738	130	0.034
response to nutrient levels	GO:0031667	109	0.034	Fly
regulation of circadian rhythm	GO:0042752	58	0.034
regulation of exit from mitosis	GO:0007096	1	0.034
positive regulation of jnk cascade	GO:0046330	46	0.033
second messenger mediated signaling	GO:0019932	73	0.033

Raf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of cellular proliferation	DOID:14566	0.762
endocrine gland cancer	DOID:170	0.446
cancer	DOID:162	0.446
organ system cancer	DOID:0050686	0.446
thoracic cancer	DOID:5093	0.112
noonan syndrome	DOID:3490	0.037	Human

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