IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Rsph1

radial spoke head 1 homolog (Chlamydomonas)

(Aliases: Tsga2,MCA)

Ensembl: ENSMUSG00000024033
Entrez: 22092
UniProtKB: Q8VIG3
UniProtKB: Q3YEA4

Process Predictions
Disease Predictions

Rsph1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cilium morphogenesis	GO:0060271	102	0.822
cilium assembly	GO:0042384	81	0.536
spermatid development	GO:0007286	108	0.391
spermatogenesis	GO:0007283	284	0.300
organelle assembly	GO:0070925	177	0.250
spermatid differentiation	GO:0048515	115	0.229
male gamete generation	GO:0048232	285	0.227
microtubule based movement	GO:0007018	84	0.227
cellular component assembly involved in morphogenesis	GO:0010927	139	0.213
germ cell development	GO:0007281	185	0.209
nucleobase containing small molecule metabolic process	GO:0055086	352	0.175
microtubule based process	GO:0007017	236	0.143
male meiosis	GO:0007140	37	0.096
purine containing compound metabolic process	GO:0072521	311	0.092
ribonucleotide metabolic process	GO:0009259	291	0.085
nucleotide metabolic process	GO:0009117	332	0.083
sperm motility	GO:0030317	47	0.073
cilium movement	GO:0003341	28	0.073
oocyte construction	GO:0007308	2	0.070
organelle fission	GO:0048285	170	0.065
male meiosis i	GO:0007141	16	0.064
meiotic cell cycle	GO:0051321	122	0.063
purine nucleotide metabolic process	GO:0006163	302	0.058
purine ribonucleotide metabolic process	GO:0009150	290	0.056
cation transport	GO:0006812	399	0.053
cellular macromolecule catabolic process	GO:0044265	206	0.052
meiotic nuclear division	GO:0007126	115	0.052
nucleoside phosphate metabolic process	GO:0006753	338	0.051
oocyte axis specification	GO:0007309	2	0.047
regulation of cell cycle process	GO:0010564	160	0.047
neuronal action potential	GO:0019228	54	0.046
epithelial cilium movement	GO:0003351	12	0.042
inorganic cation transmembrane transport	GO:0098662	207	0.041
asymmetric stem cell division	GO:0098722	3	0.040
response to oxidative stress	GO:0006979	123	0.040
nucleoside metabolic process	GO:0009116	246	0.039
regulation of presynaptic membrane organization	GO:1901629	3	0.037
nuclear division	GO:0000280	158	0.036
ribose phosphate metabolic process	GO:0019693	291	0.035
nucleoside triphosphate metabolic process	GO:0009141	230	0.034
organophosphate biosynthetic process	GO:0090407	122	0.034
germinal center formation	GO:0002467	16	0.034
baroreceptor response to increased systemic arterial blood pressure	GO:0001983	3	0.033
regulation of cellular response to stress	GO:0080135	159	0.032
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.032
protein targeting	GO:0006605	143	0.031
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.031
regulation of ion transmembrane transport	GO:0034765	119	0.031
ribonucleotide catabolic process	GO:0009261	208	0.030
regulation of nucleotide metabolic process	GO:0006140	169	0.030
development of primary sexual characteristics	GO:0045137	143	0.030
modification dependent protein catabolic process	GO:0019941	133	0.030
meiotic cell cycle process	GO:1903046	77	0.029
protein catabolic process	GO:0030163	221	0.029
regulation of fertilization	GO:0080154	4	0.029
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.029
nucleoside phosphate catabolic process	GO:1901292	222	0.028
t cell differentiation	GO:0030217	174	0.028
regulation of mapk cascade	GO:0043408	248	0.028
regulation of ion transmembrane transporter activity	GO:0032412	54	0.026
regulation of cell cycle	GO:0051726	281	0.026
ventricular system development	GO:0021591	27	0.026
inclusion body assembly	GO:0070841	3	0.026
microtubule cytoskeleton organization	GO:0000226	157	0.026
multicellular organismal homeostasis	GO:0048871	164	0.025
pole plasm assembly	GO:0007315	2	0.025
carbohydrate derivative catabolic process	GO:1901136	231	0.025
nucleotide biosynthetic process	GO:0009165	78	0.025
response to organic cyclic compound	GO:0014070	198	0.025
intracellular mrna localization	GO:0008298	4	0.025
glycosyl compound metabolic process	GO:1901657	246	0.025
establishment of protein localization to organelle	GO:0072594	118	0.024
ribonucleoside metabolic process	GO:0009119	245	0.024
organic anion transport	GO:0015711	137	0.024
cyclic purine nucleotide metabolic process	GO:0052652	43	0.024
protein localization to organelle	GO:0033365	185	0.024
protein localization to nucleus	GO:0034504	121	0.024
meiosis i	GO:0007127	60	0.024
development of primary male sexual characteristics	GO:0046546	88	0.023
rna interference	GO:0016246	2	0.023
ribonucleoprotein complex disassembly	GO:0032988	3	0.023
regulation of muscle system process	GO:0090257	80	0.023
cation transmembrane transport	GO:0098655	266	0.023
regulation of cell division	GO:0051302	76	0.022
retrograde transport endosome to golgi	GO:0042147	2	0.022
oxidation reduction process	GO:0055114	342	0.022
dna damage response signal transduction resulting in transcription	GO:0042772	2	0.022
purine nucleoside metabolic process	GO:0042278	241	0.022
purine nucleotide catabolic process	GO:0006195	211	0.022
modification dependent macromolecule catabolic process	GO:0043632	133	0.022
cellularization	GO:0007349	1	0.021
lateral inhibition	GO:0046331	1	0.021
muscle tissue development	GO:0060537	308	0.021
reactive oxygen species metabolic process	GO:0072593	84	0.021
acetylcholine transport	GO:0015870	2	0.021
multicellular organismal signaling	GO:0035637	91	0.021
glycosyl compound catabolic process	GO:1901658	206	0.021
male sex differentiation	GO:0046661	109	0.021
purine containing compound biosynthetic process	GO:0072522	70	0.021
regulation of mitotic cell cycle	GO:0007346	126	0.021
gonad development	GO:0008406	141	0.020
left right pattern formation	GO:0060972	23	0.020
regulation of acetylcholine secretion neurotransmission	GO:0014056	2	0.020
response to peptide hormone	GO:0043434	127	0.020
renal system process	GO:0003014	48	0.020
action potential	GO:0001508	78	0.020
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.020
apoptotic signaling pathway	GO:0097190	306	0.020
leukocyte differentiation	GO:0002521	342	0.020
membrane organization	GO:0061024	245	0.020
negative regulation of cell size	GO:0045792	3	0.020
positive regulation of organelle organization	GO:0010638	128	0.020
intracellular protein transport	GO:0006886	204	0.019
ion transmembrane transport	GO:0034220	361	0.019
nucleocytoplasmic transport	GO:0006913	139	0.019
regulation of vesicle mediated transport	GO:0060627	139	0.019
sensory perception	GO:0007600	245	0.019
organophosphate catabolic process	GO:0046434	232	0.019
male gonad development	GO:0008584	88	0.019
purine ribonucleotide catabolic process	GO:0009154	208	0.019
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.019
hormone metabolic process	GO:0042445	86	0.019
divalent metal ion transport	GO:0070838	172	0.019
regulation of multi organism process	GO:0043900	111	0.018
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	2	0.018
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.018
cell type specific apoptotic process	GO:0097285	268	0.018
oocyte anterior posterior axis specification	GO:0007314	2	0.018
skeletal muscle organ development	GO:0060538	163	0.018
negative regulation of cell proliferation	GO:0008285	296	0.018
fertilization	GO:0009566	127	0.018
response to reactive oxygen species	GO:0000302	56	0.018
germ line stem cell division	GO:0042078	2	0.018
midgut development	GO:0007494	4	0.018
activation of adenylate cyclase activity	GO:0007190	4	0.018
transmembrane transport	GO:0055085	412	0.018
tissue homeostasis	GO:0001894	115	0.018
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	54	0.018
response to peptide	GO:1901652	136	0.018
g protein coupled receptor signaling pathway	GO:0007186	243	0.018
response to vitamin a	GO:0033189	1	0.018
nuclear transport	GO:0051169	139	0.018
immune effector process	GO:0002252	321	0.018
protein autophosphorylation	GO:0046777	61	0.017
purine ribonucleotide biosynthetic process	GO:0009152	59	0.017
regulation of organelle organization	GO:0033043	289	0.017
regulation of lymphocyte differentiation	GO:0045619	107	0.017
establishment of organelle localization	GO:0051656	122	0.017
cell division	GO:0051301	120	0.017
response to corticosterone	GO:0051412	1	0.017
cytoplasmic transport	GO:0016482	234	0.017
regulation of neuron death	GO:1901214	134	0.017
negative regulation of cholesterol transport	GO:0032375	4	0.017
ribose phosphate biosynthetic process	GO:0046390	59	0.017
cellular response to oxidative stress	GO:0034599	76	0.016
protein import	GO:0017038	101	0.016
regulation of lymphocyte activation	GO:0051249	240	0.016
positive regulation of cyclic nucleotide biosynthetic process	GO:0030804	24	0.016
binding of sperm to zona pellucida	GO:0007339	34	0.016
carbohydrate derivative biosynthetic process	GO:1901137	183	0.016
regulation of ion transport	GO:0043269	215	0.016
nephron epithelium development	GO:0072009	92	0.016
regulation of apoptotic signaling pathway	GO:2001233	197	0.016
organelle disassembly	GO:1903008	2	0.016
positive regulation of protein modification process	GO:0031401	299	0.016
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.016
heterocycle catabolic process	GO:0046700	280	0.016
photoreceptor cell maintenance	GO:0045494	19	0.016
mapk cascade	GO:0000165	281	0.016
synaptic transmission	GO:0007268	329	0.016
purine ribonucleoside metabolic process	GO:0046128	241	0.016
mitotic cytokinesis	GO:0000281	4	0.016
response to mineralocorticoid	GO:0051385	1	0.016
response to inorganic substance	GO:0010035	96	0.016
inorganic ion transmembrane transport	GO:0098660	234	0.016
transmission of nerve impulse	GO:0019226	76	0.016
positive regulation of cellular catabolic process	GO:0031331	148	0.015
carbohydrate homeostasis	GO:0033500	128	0.015
cellular response to dna damage stimulus	GO:0006974	207	0.015
negative regulation of bone trabecula formation	GO:1900155	1	0.015
negative regulation of sterol transport	GO:0032372	4	0.015
neuron apoptotic process	GO:0051402	142	0.015
protein localization to membrane	GO:0072657	108	0.015
aromatic compound catabolic process	GO:0019439	286	0.015
stem cell development	GO:0048864	219	0.015
regulation of cell migration	GO:0030334	219	0.015
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.015
macromolecule catabolic process	GO:0009057	281	0.015
regulation of cell cycle phase transition	GO:1901987	77	0.015
cellular lipid metabolic process	GO:0044255	323	0.015
t cell activation	GO:0042110	289	0.015
nucleoside monophosphate metabolic process	GO:0009123	85	0.015
carboxylic acid transport	GO:0046942	100	0.015
organelle localization	GO:0051640	179	0.015
muscle cell fate specification	GO:0042694	1	0.014
cellular protein catabolic process	GO:0044257	155	0.014
planar cell polarity pathway involved in heart morphogenesis	GO:0061346	3	0.014
proteasomal protein catabolic process	GO:0010498	98	0.014
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.014
nitrogen compound transport	GO:0071705	271	0.014
endocytosis	GO:0006897	168	0.014
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.014
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.014
compound eye development	GO:0048749	1	0.014
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.014
mitotic cell cycle	GO:0000278	195	0.014
cytokinetic process	GO:0032506	2	0.014
heart morphogenesis	GO:0003007	178	0.013
locomotory behavior	GO:0007626	195	0.013
negative regulation of t cell activation	GO:0050868	65	0.013
purine containing compound catabolic process	GO:0072523	213	0.013
positive regulation of ion transport	GO:0043270	65	0.013
negative regulation of leukocyte differentiation	GO:1902106	51	0.013
organic hydroxy compound transport	GO:0015850	93	0.013
lymphocyte differentiation	GO:0030098	242	0.013
positive regulation of nucleotide biosynthetic process	GO:0030810	26	0.013
regulation of intracellular transport	GO:0032386	159	0.013
retina homeostasis	GO:0001895	23	0.013
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway	GO:0043162	3	0.013
regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO:1902253	13	0.013
regulation of protein processing	GO:0070613	96	0.013
positive regulation of cell development	GO:0010720	237	0.013
anatomical structure homeostasis	GO:0060249	145	0.013
nuclear import	GO:0051170	95	0.013
regulation of b cell tolerance induction	GO:0002661	2	0.013
regulation of defense response	GO:0031347	233	0.013
canonical wnt signaling pathway involved in regulation of cell proliferation	GO:0044340	3	0.013
dephosphorylation	GO:0016311	129	0.013
organic cyclic compound catabolic process	GO:1901361	295	0.013
ras protein signal transduction	GO:0007265	77	0.013
positive regulation of fibroblast proliferation	GO:0048146	20	0.013
regulation of leukocyte differentiation	GO:1902105	159	0.013
ossification	GO:0001503	216	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.012
mitotic cell cycle process	GO:1903047	159	0.012
potassium ion transmembrane transport	GO:0071805	43	0.012
regulation of nuclear division	GO:0051783	56	0.012
cyclic nucleotide metabolic process	GO:0009187	59	0.012
negative regulation of cell migration	GO:0030336	59	0.012
cellular potassium ion transport	GO:0071804	43	0.012
nucleoside phosphate biosynthetic process	GO:1901293	79	0.012
leukocyte migration	GO:0050900	124	0.012
retina development in camera type eye	GO:0060041	119	0.012
positive regulation of protein catabolic process	GO:0045732	60	0.012
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.012
postganglionic parasympathetic nervous system development	GO:0021784	2	0.012
regionalization	GO:0003002	337	0.012
mitotic sister chromatid segregation	GO:0000070	14	0.012
regulation of neuron differentiation	GO:0045664	281	0.012
regulation of proteolysis	GO:0030162	164	0.012
neuron death	GO:0070997	154	0.012
positive regulation of defense response	GO:0031349	124	0.012
cellular nitrogen compound catabolic process	GO:0044270	280	0.012
testosterone biosynthetic process	GO:0061370	2	0.012
asymmetric neuroblast division	GO:0055059	1	0.012
rho protein signal transduction	GO:0007266	32	0.012
cellular metal ion homeostasis	GO:0006875	151	0.012
alcohol metabolic process	GO:0006066	116	0.012
localization within membrane	GO:0051668	4	0.012
gtp metabolic process	GO:0046039	144	0.012
positive regulation of cellular amine metabolic process	GO:0033240	5	0.012
camera type eye development	GO:0043010	266	0.012
signal transduction by p53 class mediator	GO:0072331	51	0.012
regulation of meiotic cell cycle	GO:0051445	34	0.012
actin cytoskeleton organization	GO:0030036	220	0.012
g protein coupled acetylcholine receptor signaling pathway	GO:0007213	4	0.011
positive regulation of mapk cascade	GO:0043410	170	0.011
mitochondrion organization	GO:0007005	134	0.011
dna repair	GO:0006281	107	0.011
purine nucleotide biosynthetic process	GO:0006164	65	0.011
cell cell recognition	GO:0009988	44	0.011
negative regulation of intracellular signal transduction	GO:1902532	167	0.011
regulation of purine nucleotide metabolic process	GO:1900542	169	0.011
negative regulation of neuron apoptotic process	GO:0043524	92	0.011
purine ribonucleoside catabolic process	GO:0046130	205	0.011
interspecies interaction between organisms	GO:0044419	83	0.011
positive regulation of camp biosynthetic process	GO:0030819	19	0.011
posttranscriptional regulation of gene expression	GO:0010608	155	0.011
negative regulation of cholesterol efflux	GO:0090370	4	0.011
positive regulation of cell cycle	GO:0045787	92	0.011
positive regulation of transferase activity	GO:0051347	167	0.011
cell cycle g2 m phase transition	GO:0044839	20	0.011
regulation of protein transport	GO:0051223	163	0.011
chromosome segregation	GO:0007059	48	0.011
leukocyte activation involved in immune response	GO:0002366	126	0.011
cellular calcium ion homeostasis	GO:0006874	119	0.011
negative regulation of cellular component organization	GO:0051129	194	0.011
ubiquitin dependent protein catabolic process	GO:0006511	129	0.011
regulation of transmembrane transport	GO:0034762	128	0.011
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	35	0.011
regulation of neuron projection development	GO:0010975	169	0.011
epithelial cell development	GO:0002064	159	0.011
cellular ketone metabolic process	GO:0042180	84	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.011
positive regulation of potassium ion transmembrane transport	GO:1901381	3	0.011
purine nucleoside catabolic process	GO:0006152	205	0.011
cellular amino acid metabolic process	GO:0006520	103	0.011
positive regulation of cell death	GO:0010942	224	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.011
regulation of cellular ketone metabolic process	GO:0010565	66	0.011
nucleoside triphosphate catabolic process	GO:0009143	205	0.011
regulation of cholesterol transport	GO:0032374	17	0.010
negative regulation of immune system process	GO:0002683	209	0.010
sensory perception of pain	GO:0019233	47	0.010
regulation of cellular catabolic process	GO:0031329	242	0.010
forebrain development	GO:0030900	302	0.010
sperm egg recognition	GO:0035036	37	0.010
protein maturation	GO:0051604	176	0.010
cellular protein complex assembly	GO:0043623	116	0.010
mesodermal cell migration	GO:0008078	4	0.010
negative regulation of protein phosphorylation	GO:0001933	126	0.010
stress activated mapk cascade	GO:0051403	80	0.010
regulation of hormone levels	GO:0010817	211	0.010
divalent inorganic cation homeostasis	GO:0072507	138	0.010
rna processing	GO:0006396	105	0.010
positive regulation of necrotic cell death	GO:0010940	1	0.010
metencephalon development	GO:0022037	89	0.010
heart contraction	GO:0060047	93	0.010
protein alkylation	GO:0008213	81	0.010
amide transport	GO:0042886	138	0.010
regulation of rho protein signal transduction	GO:0035023	71	0.010
regulation of reproductive process	GO:2000241	66	0.010

Rsph1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
primary ciliary dyskinesia	DOID:9562	0.114
organ system cancer	DOID:0050686	0.036
disease of cellular proliferation	DOID:14566	0.036
cancer	DOID:162	0.036
nervous system disease	DOID:863	0.024
neurodegenerative disease	DOID:1289	0.024
central nervous system disease	DOID:331	0.024
disease of anatomical entity	DOID:7	0.024
retinal disease	DOID:5679	0.017
sensory system disease	DOID:0050155	0.017
retinal degeneration	DOID:8466	0.017
eye disease	DOID:5614	0.017
eye and adnexa disease	DOID:1492	0.017
connective tissue disease	DOID:65	0.016
musculoskeletal system disease	DOID:17	0.016
bone disease	DOID:0080001	0.011

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