IMP: Integrative Multi-species Prediction

Mus musculus

68 known processes

Sim1

single-minded homolog 1 (Drosophila)

(Aliases: mSIM1,bHLHe14)

Entrez: 20464
Ensembl: ENSMUSG00000019913
UniProtKB: Q61045

Process Predictions
Disease Predictions

Sim1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
forebrain development	GO:0030900	302	0.979	Zebrafish Mouse
endocrine system development	GO:0035270	98	0.896
hypothalamus cell differentiation	GO:0021979	8	0.883	Zebrafish
forebrain neuron differentiation	GO:0021879	52	0.825
columnar cuboidal epithelial cell development	GO:0002066	29	0.812	Mouse
response to peptide hormone	GO:0043434	127	0.795
peptide transport	GO:0015833	133	0.769	Mouse
forebrain generation of neurons	GO:0021872	63	0.759
telencephalon development	GO:0021537	186	0.743	Mouse
chemotaxis	GO:0006935	247	0.707	Zebrafish Fly
cellular response to peptide	GO:1901653	92	0.704
gliogenesis	GO:0042063	141	0.700
multicellular organism growth	GO:0035264	161	0.679
hindbrain development	GO:0030902	128	0.676
cellular response to peptide hormone stimulus	GO:0071375	92	0.636
central nervous system neuron differentiation	GO:0021953	162	0.634
diencephalon development	GO:0021536	63	0.616	Zebrafish
limbic system development	GO:0021761	72	0.613	Zebrafish
muscle cell differentiation	GO:0042692	261	0.592	Mouse
axonogenesis	GO:0007409	274	0.586	Zebrafish Fly
neuroblast proliferation	GO:0007405	49	0.577	Mouse
stem cell differentiation	GO:0048863	268	0.565	Mouse
epithelial cell development	GO:0002064	159	0.551	Mouse
columnar cuboidal epithelial cell maturation	GO:0002069	4	0.539	Mouse
neuron projection guidance	GO:0097485	141	0.535	Zebrafish Fly
pallium development	GO:0021543	120	0.527	Mouse
embryonic organ morphogenesis	GO:0048562	276	0.522	Mouse
positive regulation of nervous system development	GO:0051962	221	0.518	Mouse
neuron fate specification	GO:0048665	30	0.513
insulin secretion	GO:0030073	89	0.509	Mouse
skin development	GO:0043588	220	0.497
angiogenesis	GO:0001525	201	0.492	Mouse
developmental maturation	GO:0021700	193	0.492	Mouse
cerebral cortex development	GO:0021987	86	0.491	Mouse
hypothalamus development	GO:0021854	16	0.491	Zebrafish
gland development	GO:0048732	330	0.489	Mouse
sensory organ morphogenesis	GO:0090596	242	0.487
cell fate specification	GO:0001708	72	0.480
metal ion homeostasis	GO:0055065	189	0.478	Mouse
embryonic placenta development	GO:0001892	98	0.472	Mouse
neural precursor cell proliferation	GO:0061351	121	0.462	Mouse
positive regulation of cell development	GO:0010720	237	0.459	Mouse
stem cell development	GO:0048864	219	0.458	Mouse
regulation of wnt signaling pathway	GO:0030111	123	0.454
negative regulation of neuron death	GO:1901215	98	0.452	Mouse
inorganic anion transport	GO:0015698	43	0.443
cellular response to hormone stimulus	GO:0032870	150	0.440
glandular epithelial cell differentiation	GO:0002067	38	0.437
axon guidance	GO:0007411	141	0.437	Zebrafish Fly
pancreas development	GO:0031016	57	0.437
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.430
cell fate commitment	GO:0045165	210	0.421	Mouse Fly
nephron tubule development	GO:0072080	84	0.419
cell adhesion	GO:0007155	329	0.417
response to insulin	GO:0032868	100	0.412
response to organonitrogen compound	GO:0010243	246	0.411
retina development in camera type eye	GO:0060041	119	0.406	Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.390	Mouse
response to growth factor	GO:0070848	198	0.388	Mouse
glycolytic process	GO:0006096	20	0.387	Mouse
response to peptide	GO:1901652	136	0.385
cerebral cortex radially oriented cell migration	GO:0021799	31	0.380
spinal cord development	GO:0021510	81	0.372
carbohydrate homeostasis	GO:0033500	128	0.372	Mouse
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.371
nuclear transport	GO:0051169	139	0.363
mesonephric tubule development	GO:0072164	94	0.355
tube formation	GO:0035148	140	0.354	Mouse
regulation of hormone levels	GO:0010817	211	0.353	Mouse
outflow tract morphogenesis	GO:0003151	53	0.353	Mouse
protein modification by small protein conjugation or removal	GO:0070647	207	0.353
anion transport	GO:0006820	177	0.353
skeletal system morphogenesis	GO:0048705	203	0.352
neurohypophysis development	GO:0021985	2	0.350
second messenger mediated signaling	GO:0019932	73	0.346
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.342	Mouse
intestinal epithelial cell maturation	GO:0060574	2	0.340	Mouse
regulation of carbohydrate metabolic process	GO:0006109	75	0.339	Mouse
regulation of cell migration	GO:0030334	219	0.332	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.324	Mouse
hormone secretion	GO:0046879	128	0.324	Mouse
skeletal muscle cell differentiation	GO:0035914	66	0.324
leukocyte differentiation	GO:0002521	342	0.322
cellular response to organonitrogen compound	GO:0071417	145	0.320
cellular amino acid metabolic process	GO:0006520	103	0.315
spermatogenesis	GO:0007283	284	0.311
cell proliferation in hindbrain	GO:0021534	10	0.310
negative regulation of intracellular signal transduction	GO:1902532	167	0.309	Mouse
eye photoreceptor cell differentiation	GO:0001754	41	0.305
forebrain cell migration	GO:0021885	58	0.305
purine nucleotide biosynthetic process	GO:0006164	65	0.303
kidney development	GO:0001822	213	0.302
regulation of canonical wnt signaling pathway	GO:0060828	82	0.302
cell differentiation in spinal cord	GO:0021515	53	0.302
central nervous system neuron development	GO:0021954	67	0.302
modification dependent protein catabolic process	GO:0019941	133	0.297
male gamete generation	GO:0048232	285	0.295
cardiac ventricle morphogenesis	GO:0003208	50	0.295	Mouse
endocrine pancreas development	GO:0031018	29	0.278
regulation of tor signaling	GO:0032006	17	0.278	Mouse
heart morphogenesis	GO:0003007	178	0.277	Mouse
determination of left right symmetry	GO:0007368	80	0.276	Mouse
forebrain neuron fate commitment	GO:0021877	13	0.276
regulation of cell motility	GO:2000145	236	0.269	Mouse
urogenital system development	GO:0001655	261	0.268
canonical wnt signaling pathway	GO:0060070	130	0.266
blood vessel morphogenesis	GO:0048514	285	0.266	Mouse
regulation of organ morphogenesis	GO:2000027	144	0.264
trachea cartilage morphogenesis	GO:0060535	4	0.262
epidermis development	GO:0008544	187	0.262
cellular amine metabolic process	GO:0044106	44	0.262
spinal cord association neuron differentiation	GO:0021527	14	0.262
cellular ion homeostasis	GO:0006873	165	0.260	Mouse
granulocyte colony stimulating factor production	GO:0071611	1	0.258
embryonic epithelial tube formation	GO:0001838	130	0.256	Mouse
regulation of neuron differentiation	GO:0045664	281	0.252
protein modification by small protein conjugation	GO:0032446	187	0.252
cellular response to oxidative stress	GO:0034599	76	0.251	Mouse
positive regulation of neuron differentiation	GO:0045666	141	0.251
cellular carbohydrate metabolic process	GO:0044262	119	0.246	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.239
response to oxygen levels	GO:0070482	62	0.238	Mouse
renal tubule development	GO:0061326	87	0.236
regulation of carbohydrate biosynthetic process	GO:0043255	40	0.235
glial cell differentiation	GO:0010001	131	0.234
protein localization to nucleus	GO:0034504	121	0.234
development of primary male sexual characteristics	GO:0046546	88	0.230
response to acid chemical	GO:0001101	111	0.229
lung cell differentiation	GO:0060479	30	0.228
regulation of peptide hormone secretion	GO:0090276	75	0.226	Mouse
spinal cord motor neuron differentiation	GO:0021522	35	0.225
dorsal spinal cord development	GO:0021516	20	0.224
neural crest cell development	GO:0014032	48	0.222	Mouse
neuron death	GO:0070997	154	0.221	Mouse
developmental cell growth	GO:0048588	84	0.220
neuron apoptotic process	GO:0051402	142	0.220	Mouse
forebrain neuron development	GO:0021884	30	0.216
morphogenesis of a branching epithelium	GO:0061138	193	0.215
neural fold elevation formation	GO:0021502	1	0.214	Mouse
stem cell division	GO:0017145	30	0.213
nucleotide metabolic process	GO:0009117	332	0.212
muscle tissue development	GO:0060537	308	0.207
metanephric loop of henle development	GO:0072236	4	0.206
regulation of blood circulation	GO:1903522	93	0.206	Mouse
response to oxidative stress	GO:0006979	123	0.203	Mouse
neural tube formation	GO:0001841	108	0.203	Mouse
rhythmic process	GO:0048511	174	0.202
nitrogen compound transport	GO:0071705	271	0.202	Mouse
establishment of protein localization to organelle	GO:0072594	118	0.200
regulation of myeloid cell differentiation	GO:0045637	96	0.199	Mouse
digestive tract development	GO:0048565	190	0.199	Mouse
regulation of ion transport	GO:0043269	215	0.199
lung development	GO:0030324	164	0.199	Mouse
protein import	GO:0017038	101	0.198
mesenchymal cell development	GO:0014031	93	0.198	Mouse
respiratory system development	GO:0060541	190	0.197	Mouse
negative regulation of neuron apoptotic process	GO:0043524	92	0.197	Mouse
divalent inorganic cation homeostasis	GO:0072507	138	0.197
renal system development	GO:0072001	225	0.197
motor neuron migration	GO:0097475	4	0.196
morphogenesis of embryonic epithelium	GO:0016331	159	0.196	Mouse
regionalization	GO:0003002	337	0.196
organic hydroxy compound transport	GO:0015850	93	0.194
ectoderm formation	GO:0001705	3	0.194
hair cell differentiation	GO:0035315	40	0.192
lateral motor column neuron migration	GO:0097477	3	0.191
organophosphate biosynthetic process	GO:0090407	122	0.190
positive regulation of auditory receptor cell differentiation	GO:0045609	1	0.189
response to monosaccharide	GO:0034284	67	0.189	Mouse
ureteric bud development	GO:0001657	94	0.189
intraspecies interaction between organisms	GO:0051703	21	0.189
glucose homeostasis	GO:0042593	128	0.188	Mouse
inner ear morphogenesis	GO:0042472	101	0.185
mammary gland lobule development	GO:0061377	22	0.182	Mouse
subpallium neuron fate commitment	GO:0060163	2	0.182
neural tube development	GO:0021915	160	0.176	Mouse
cerebral cortex cell migration	GO:0021795	44	0.175
b cell activation	GO:0042113	161	0.175
regulation of secretion by cell	GO:1903530	249	0.175	Mouse
dendrite development	GO:0016358	115	0.175
amine metabolic process	GO:0009308	45	0.174
telencephalon cell migration	GO:0022029	55	0.173
peripheral nervous system neuron axonogenesis	GO:0048936	3	0.173
potassium ion transport	GO:0006813	52	0.172
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000802	1	0.171
cell maturation	GO:0048469	127	0.171	Mouse
kidney epithelium development	GO:0072073	121	0.170
modification dependent macromolecule catabolic process	GO:0043632	133	0.169
striated muscle tissue development	GO:0014706	293	0.169
olfactory bulb development	GO:0021772	30	0.168
mechanoreceptor differentiation	GO:0042490	67	0.167
positive regulation of mesonephros development	GO:0061213	20	0.167
type b pancreatic cell differentiation	GO:0003309	13	0.166
cation homeostasis	GO:0055080	212	0.166	Mouse
cellular ketone metabolic process	GO:0042180	84	0.166
placenta development	GO:0001890	140	0.165	Mouse
response to nutrient levels	GO:0031667	109	0.165
positive regulation of growth	GO:0045927	104	0.164
cranial nerve development	GO:0021545	41	0.163
digestive system development	GO:0055123	200	0.161	Mouse
ubiquitin dependent protein catabolic process	GO:0006511	129	0.161
regulation of cellular response to stress	GO:0080135	159	0.159
carbohydrate transport	GO:0008643	62	0.157
wnt signaling pathway	GO:0016055	188	0.156
negative regulation of fat cell differentiation	GO:0045599	36	0.156
nephron development	GO:0072006	109	0.156
somatotropin secreting cell differentiation	GO:0060126	4	0.155
positive regulation of skeletal muscle cell differentiation	GO:2001016	4	0.154
ear morphogenesis	GO:0042471	118	0.154
negative regulation of wnt signaling pathway	GO:0030178	73	0.154
mesoderm development	GO:0007498	100	0.154
fat cell differentiation	GO:0045444	160	0.151
positive regulation of protein modification process	GO:0031401	299	0.151
regulation of carbohydrate catabolic process	GO:0043470	12	0.150	Mouse
tube closure	GO:0060606	91	0.150
embryonic skeletal system development	GO:0048706	120	0.150
regulation of organ formation	GO:0003156	34	0.150
regulation of peptide secretion	GO:0002791	77	0.149	Mouse
mesenchyme development	GO:0060485	152	0.148	Mouse
formation of primary germ layer	GO:0001704	77	0.147
inner ear receptor cell differentiation	GO:0060113	61	0.145
metanephric dct cell differentiation	GO:0072240	3	0.144
phenol containing compound metabolic process	GO:0018958	60	0.143	Mouse
camera type eye development	GO:0043010	266	0.143	Mouse
cardiac muscle tissue morphogenesis	GO:0055008	44	0.142
protein import into nucleus translocation	GO:0000060	12	0.142
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.142
lung epithelial cell differentiation	GO:0060487	29	0.141
enteroendocrine cell differentiation	GO:0035883	16	0.140
cell growth	GO:0016049	130	0.139
neural crest cell migration	GO:0001755	32	0.139	Mouse
epithelial tube formation	GO:0072175	130	0.138	Mouse
aortic valve morphogenesis	GO:0003180	4	0.138
cell proliferation in forebrain	GO:0021846	30	0.138
negative regulation of nervous system development	GO:0051961	156	0.136
nucleoside phosphate metabolic process	GO:0006753	338	0.136
response to extracellular stimulus	GO:0009991	127	0.135
cellular response to insulin stimulus	GO:0032869	78	0.134
trophectodermal cell differentiation	GO:0001829	21	0.133
positive regulation of inner ear receptor cell differentiation	GO:2000982	1	0.133
nephron epithelium development	GO:0072009	92	0.133
inorganic ion transmembrane transport	GO:0098660	234	0.132
neuron migration	GO:0001764	122	0.132
purine ribonucleotide biosynthetic process	GO:0009152	59	0.132
stem cell maintenance	GO:0019827	130	0.132
visceral motor neuron differentiation	GO:0021524	3	0.130
peptidyl amino acid modification	GO:0018193	336	0.130
lymphocyte differentiation	GO:0030098	242	0.129
negative regulation of molecular function	GO:0044092	258	0.128
morphogenesis of a branching structure	GO:0001763	203	0.127
cell type specific apoptotic process	GO:0097285	268	0.127	Mouse
cellular macromolecule catabolic process	GO:0044265	206	0.126
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process	GO:2000763	1	0.126
b cell differentiation	GO:0030183	78	0.126
negative regulation of tor signaling	GO:0032007	13	0.125	Mouse
spleen development	GO:0048536	39	0.124
cerebral cortex gabaergic interneuron differentiation	GO:0021892	9	0.123
dopaminergic neuron differentiation	GO:0071542	14	0.123	Zebrafish Mouse
g protein coupled receptor signaling pathway	GO:0007186	243	0.122
glucose import	GO:0046323	32	0.122
transdifferentiation	GO:0060290	1	0.122
cellular glucose homeostasis	GO:0001678	52	0.121	Mouse
cell division	GO:0051301	120	0.121
mesoderm formation	GO:0001707	62	0.121
development of primary sexual characteristics	GO:0045137	143	0.121
astrocyte fate commitment	GO:0060018	4	0.120
olfactory lobe development	GO:0021988	32	0.118
cellular chemical homeostasis	GO:0055082	215	0.118	Mouse
kidney morphogenesis	GO:0060993	83	0.118
regulation of glucose metabolic process	GO:0010906	60	0.118
ear development	GO:0043583	200	0.118
monosaccharide metabolic process	GO:0005996	106	0.117
hormone metabolic process	GO:0042445	86	0.117
regulation of neuron death	GO:1901214	134	0.116	Mouse
negative regulation of phosphate metabolic process	GO:0045936	184	0.116
blastocyst development	GO:0001824	80	0.116
cerebellar granule cell precursor proliferation	GO:0021930	10	0.116
regulation of retina development in camera type eye	GO:1902866	3	0.115
astrocyte differentiation	GO:0048708	43	0.115
sensory system development	GO:0048880	3	0.115
locomotory behavior	GO:0007626	195	0.115	Mouse Fly
bmp signaling pathway	GO:0030509	93	0.114
mesenchymal cell differentiation	GO:0048762	107	0.114	Mouse
cardiac chamber development	GO:0003205	108	0.113	Mouse
myeloid cell homeostasis	GO:0002262	114	0.113	Mouse
nucleocytoplasmic transport	GO:0006913	139	0.112
regulation of glycogen metabolic process	GO:0070873	13	0.112
branching morphogenesis of an epithelial tube	GO:0048754	159	0.111
ventricular system development	GO:0021591	27	0.111
cardiac cell fate determination	GO:0060913	2	0.109
stem cell proliferation	GO:0072089	117	0.109	Mouse
negative regulation of canonical wnt signaling pathway	GO:0090090	51	0.109
response to light stimulus	GO:0009416	135	0.109	Mouse
regulation of secretion	GO:0051046	274	0.109	Mouse
ribose phosphate biosynthetic process	GO:0046390	59	0.108
motor neuron axon guidance	GO:0008045	26	0.108
ribonucleotide metabolic process	GO:0009259	291	0.107
semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:0071527	1	0.107
regulation of protein localization	GO:0032880	231	0.107
ventral spinal cord interneuron fate commitment	GO:0060579	14	0.107
regulation of cellular catabolic process	GO:0031329	242	0.105	Mouse
regulation of stem cell proliferation	GO:0072091	78	0.105	Mouse
oxidation reduction process	GO:0055114	342	0.104
lymphocyte activation involved in immune response	GO:0002285	93	0.104
blastocyst formation	GO:0001825	33	0.104
positive regulation of secondary heart field cardioblast proliferation	GO:0072513	4	0.104
carbohydrate biosynthetic process	GO:0016051	74	0.103
brain segmentation	GO:0035284	3	0.103
auditory receptor cell fate specification	GO:0042667	1	0.103
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification	GO:0021913	4	0.103
appendage morphogenesis	GO:0035107	149	0.101
regulation of epithelial cell proliferation	GO:0050678	141	0.101
pituitary gland development	GO:0021983	38	0.101
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.100
regulation of cell cycle	GO:0051726	281	0.100
pancreatic a cell fate commitment	GO:0003326	2	0.100
respiratory tube development	GO:0030323	167	0.099	Mouse
neuron maturation	GO:0042551	29	0.099
neural crest cell differentiation	GO:0014033	54	0.099	Mouse
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000800	1	0.098
spinal cord motor neuron cell fate specification	GO:0021520	13	0.098
response to testosterone	GO:0033574	3	0.098
positive regulation of peptide secretion	GO:0002793	33	0.098	Mouse
ion transmembrane transport	GO:0034220	361	0.097
protein import into nucleus	GO:0006606	95	0.097
cognition	GO:0050890	149	0.096	Mouse
regulation of circadian sleep wake cycle sleep	GO:0045187	3	0.096
limb development	GO:0060173	166	0.096
asymmetric stem cell division	GO:0098722	3	0.095
peripheral nervous system neuron development	GO:0048935	9	0.095
somatotropin secreting cell development	GO:0060133	2	0.095
cyclic purine nucleotide metabolic process	GO:0052652	43	0.095
photoreceptor cell differentiation	GO:0046530	52	0.093
cell cell signaling involved in cell fate commitment	GO:0045168	35	0.093
autonomic nervous system development	GO:0048483	43	0.093
positive regulation of stem cell proliferation	GO:2000648	59	0.093	Mouse
regulation of neural retina development	GO:0061074	3	0.093
mesenchymal cell apoptotic process	GO:0097152	14	0.092	Mouse
cardiac neural crest cell migration involved in outflow tract morphogenesis	GO:0003253	3	0.092
body morphogenesis	GO:0010171	45	0.091
regulation of protein transport	GO:0051223	163	0.091
regulation of glycolytic process	GO:0006110	10	0.090	Mouse
photoreceptor cell development	GO:0042461	40	0.090
somitogenesis	GO:0001756	69	0.090
protein localization to organelle	GO:0033365	185	0.090
male sex determination	GO:0030238	14	0.090
alpha beta t cell differentiation	GO:0046632	69	0.090
ventral spinal cord development	GO:0021517	48	0.090
cytoplasmic transport	GO:0016482	234	0.089
regulation of nucleotide metabolic process	GO:0006140	169	0.089
hindlimb morphogenesis	GO:0035137	42	0.088
cell proliferation in external granule layer	GO:0021924	10	0.087
nucleobase containing small molecule metabolic process	GO:0055086	352	0.087
positive regulation of glycolytic process	GO:0045821	4	0.086
positive regulation of programmed cell death	GO:0043068	218	0.085
single organism cell adhesion	GO:0098602	156	0.085
male sex differentiation	GO:0046661	109	0.085
spinal cord motor neuron migration	GO:0097476	4	0.085
positive regulation of cell cycle	GO:0045787	92	0.085
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:2000764	1	0.084
positive regulation of neural precursor cell proliferation	GO:2000179	42	0.084	Mouse
oviduct development	GO:0060066	3	0.083
ventricular septum development	GO:0003281	42	0.083
lung epithelium development	GO:0060428	37	0.083
ribonucleotide biosynthetic process	GO:0009260	59	0.083
nephron tubule morphogenesis	GO:0072078	68	0.083
glial cell development	GO:0021782	54	0.083
cation transport	GO:0006812	399	0.082
regulation of auditory receptor cell differentiation	GO:0045607	4	0.081
regulation of anatomical structure size	GO:0090066	178	0.080
forelimb morphogenesis	GO:0035136	40	0.080
apoptotic mitochondrial changes	GO:0008637	48	0.079
calcium ion homeostasis	GO:0055074	127	0.079
regulation of glucose transport	GO:0010827	32	0.079
cell cell signaling involved in mammary gland development	GO:0060764	2	0.079
response to organic cyclic compound	GO:0014070	198	0.079
auditory receptor cell differentiation	GO:0042491	37	0.079
epithelial cell proliferation	GO:0050673	174	0.078
mammary gland duct morphogenesis	GO:0060603	38	0.078
regulation of interleukin 1 alpha production	GO:0032650	4	0.078
glucose metabolic process	GO:0006006	92	0.078
response to steroid hormone	GO:0048545	56	0.078
positive regulation of insulin secretion	GO:0032024	26	0.078	Mouse
embryonic skeletal system morphogenesis	GO:0048704	91	0.078
muscle tissue morphogenesis	GO:0060415	53	0.077
carbohydrate metabolic process	GO:0005975	230	0.077	Mouse
thick ascending limb development	GO:0072023	2	0.077
appendage development	GO:0048736	166	0.077
cardiac chamber morphogenesis	GO:0003206	93	0.076	Mouse
gabaergic neuron differentiation	GO:0097154	11	0.076
cardiocyte differentiation	GO:0035051	87	0.076
hindbrain morphogenesis	GO:0021575	46	0.076
bronchiole development	GO:0060435	3	0.076
specification of organ identity	GO:0010092	30	0.075
tor signaling	GO:0031929	21	0.075	Mouse
peptide secretion	GO:0002790	114	0.075	Mouse
exocrine system development	GO:0035272	45	0.075
mesoderm morphogenesis	GO:0048332	64	0.075
peptide hormone secretion	GO:0030072	109	0.075	Mouse
glossopharyngeal nerve morphogenesis	GO:0021615	4	0.074
mitral valve development	GO:0003174	4	0.074
glucose transport	GO:0015758	56	0.073
regulation of fat cell differentiation	GO:0045598	81	0.073
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.073
cytosolic calcium ion homeostasis	GO:0051480	70	0.073
positive regulation of peptide hormone secretion	GO:0090277	31	0.073	Mouse
positive regulation of epithelial cell differentiation involved in kidney development	GO:2000698	2	0.072
regulation of generation of precursor metabolites and energy	GO:0043467	38	0.072	Mouse
hippocampus development	GO:0021766	52	0.072
negative regulation of secretion by cell	GO:1903531	54	0.071
regulation of vasculature development	GO:1901342	88	0.071
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.071
cellular response to starvation	GO:0009267	57	0.070
hexose metabolic process	GO:0019318	98	0.070
oligodendrocyte differentiation	GO:0048709	53	0.070
auditory receptor cell fate determination	GO:0042668	3	0.070
regulation of insulin receptor signaling pathway	GO:0046626	21	0.070
response to decreased oxygen levels	GO:0036293	59	0.070	Mouse
regulation of transporter activity	GO:0032409	57	0.069
regulation of kinase activity	GO:0043549	249	0.068
regulation of morphogenesis of a branching structure	GO:0060688	53	0.068
tendon formation	GO:0035992	4	0.067
methionine transport	GO:0015821	1	0.067
cardiac ventricle development	GO:0003231	83	0.067	Mouse
regulation of mapk cascade	GO:0043408	248	0.067
glycogen metabolic process	GO:0005977	32	0.067
positive regulation of cell migration	GO:0030335	109	0.066	Mouse
syncytium formation by plasma membrane fusion	GO:0000768	42	0.066
cerebral cortex neuron differentiation	GO:0021895	19	0.066
response to transforming growth factor beta	GO:0071559	88	0.065
glucose 6 phosphate metabolic process	GO:0051156	8	0.065
cellular protein catabolic process	GO:0044257	155	0.064
gonad development	GO:0008406	141	0.064
negative regulation of cellular carbohydrate metabolic process	GO:0010677	19	0.064
positive regulation of cell motility	GO:2000147	116	0.064	Mouse
negative regulation of neuron differentiation	GO:0045665	101	0.064
retina morphogenesis in camera type eye	GO:0060042	45	0.064
intracellular protein transport	GO:0006886	204	0.064
regulation of neuron apoptotic process	GO:0043523	122	0.063	Mouse
myeloid cell differentiation	GO:0030099	233	0.063	Mouse
dct cell differentiation	GO:0072069	3	0.063
organic anion transport	GO:0015711	137	0.063
t cell differentiation	GO:0030217	174	0.063
connective tissue development	GO:0061448	179	0.063	Mouse
protein targeting	GO:0006605	143	0.062
adult behavior	GO:0030534	135	0.062	Fly
sclerotome development	GO:0061056	4	0.062
multi organism behavior	GO:0051705	62	0.062	Mouse
regulation of system process	GO:0044057	200	0.062	Mouse
circadian regulation of gene expression	GO:0032922	48	0.062
regulation of circadian rhythm	GO:0042752	58	0.061
regulation of glucan biosynthetic process	GO:0010962	7	0.061
positive regulation of muscle tissue development	GO:1901863	32	0.061
neuron projection extension	GO:1990138	64	0.061
peptidyl tyrosine modification	GO:0018212	145	0.060
ventral spinal cord interneuron differentiation	GO:0021514	16	0.060
paraxial mesodermal cell fate commitment	GO:0048343	2	0.060
germ cell development	GO:0007281	185	0.059
chondrocyte differentiation	GO:0002062	72	0.059
proteasomal protein catabolic process	GO:0010498	98	0.059
negative regulation of cell development	GO:0010721	169	0.059
positive regulation of glial cell proliferation	GO:0060252	4	0.058
neuroblast differentiation	GO:0014016	2	0.058
positive regulation of wnt signaling pathway	GO:0030177	45	0.058
renal tubule morphogenesis	GO:0061333	72	0.057
associative learning	GO:0008306	61	0.057	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.057
regulation of purine nucleotide metabolic process	GO:1900542	169	0.056
respiratory system process	GO:0003016	25	0.056
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.056
peripheral nervous system development	GO:0007422	53	0.056
monosaccharide transport	GO:0015749	58	0.056
regulation of erythrocyte differentiation	GO:0045646	23	0.056	Mouse
digestive tract morphogenesis	GO:0048546	147	0.056	Mouse
neural tube closure	GO:0001843	90	0.055
regulation of embryonic development	GO:0045995	71	0.055
regulation of cellular component biogenesis	GO:0044087	181	0.055
hexose transport	GO:0008645	56	0.055
regulation of cellular amine metabolic process	GO:0033238	20	0.055
female sex differentiation	GO:0046660	84	0.055
negative regulation of gluconeogenesis	GO:0045721	9	0.055
leukocyte proliferation	GO:0070661	172	0.055
pancreatic pp cell fate commitment	GO:0003329	2	0.054
regulation of cardiac chamber morphogenesis	GO:1901219	2	0.054
negative regulation of phosphorylation	GO:0042326	166	0.054
lateral inhibition	GO:0046331	1	0.054
ectodermal placode formation	GO:0060788	16	0.054

Sim1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of metabolism	DOID:0014667	0.473	Human
diabetes mellitus	DOID:9351	0.275
type 2 diabetes mellitus	DOID:9352	0.275
carbohydrate metabolism disease	DOID:0050013	0.275
glucose metabolism disease	DOID:4194	0.275
acquired metabolic disease	DOID:0060158	0.275	Human
carbohydrate metabolic disorder	DOID:2978	0.223
inherited metabolic disorder	DOID:655	0.223
disease of cellular proliferation	DOID:14566	0.057

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