IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Slc5a2

solute carrier family 5 (sodium/glucose cotransporter), member 2

(Aliases: Sglt2)

Entrez: 246787
Ensembl: ENSMUSG00000030781
UniProtKB: Q923I7

Process Predictions
Disease Predictions

Slc5a2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
hexose transmembrane transport	GO:0035428	7	1.000	Rat
anion transport	GO:0006820	177	0.955
chloride transmembrane transport	GO:1902476	24	0.952
chloride transport	GO:0006821	32	0.930
inorganic anion transmembrane transport	GO:0098661	29	0.883
inorganic anion transport	GO:0015698	43	0.854
hydrogen ion transmembrane transport	GO:1902600	25	0.853
ion transmembrane transport	GO:0034220	361	0.836	Rat
glucose transport	GO:0015758	56	0.814	Rat
kidney development	GO:0001822	213	0.702
organic anion transport	GO:0015711	137	0.675
fluid transport	GO:0042044	14	0.669
response to osmotic stress	GO:0006970	21	0.631
transmembrane transport	GO:0055085	412	0.508	Rat
vitamin transport	GO:0051180	10	0.507
cation transport	GO:0006812	399	0.492	Rat
inorganic ion transmembrane transport	GO:0098660	234	0.472	Rat
sodium ion transport	GO:0006814	73	0.419	Rat
inorganic cation transmembrane transport	GO:0098662	207	0.412	Rat
urea transport	GO:0015840	4	0.399
renal system process	GO:0003014	48	0.399
monosaccharide transport	GO:0015749	58	0.384	Rat
proton transport	GO:0015992	35	0.345
hypotonic response	GO:0006971	3	0.336
carbohydrate transmembrane transport	GO:0034219	10	0.336	Rat
urea transmembrane transport	GO:0071918	2	0.327
carbohydrate transport	GO:0008643	62	0.327	Rat
cation transmembrane transport	GO:0098655	266	0.321	Rat
urogenital system development	GO:0001655	261	0.318
monocarboxylic acid metabolic process	GO:0032787	191	0.306
spermatogenesis	GO:0007283	284	0.306
dehydroascorbic acid transport	GO:0070837	3	0.279
nitrogen compound transport	GO:0071705	271	0.276
establishment of blood nerve barrier	GO:0008065	3	0.275
monovalent inorganic cation homeostasis	GO:0055067	33	0.260
renal sodium ion transport	GO:0003096	2	0.251
small molecule biosynthetic process	GO:0044283	132	0.211
eye photoreceptor cell differentiation	GO:0001754	41	0.200
photoreceptor cell differentiation	GO:0046530	52	0.199
kidney epithelium development	GO:0072073	121	0.196
immune response in mucosal associated lymphoid tissue	GO:0002386	2	0.194
nephron epithelium development	GO:0072009	92	0.174
neuronal action potential	GO:0019228	54	0.173
central nervous system neuron development	GO:0021954	67	0.172
carnitine transmembrane transport	GO:1902603	3	0.167
carboxylic acid transport	GO:0046942	100	0.157
response to fructose	GO:0009750	2	0.155
anion transmembrane transport	GO:0098656	71	0.151
multicellular organism growth	GO:0035264	161	0.148
organic acid transport	GO:0015849	101	0.141
retina development in camera type eye	GO:0060041	119	0.140
bile acid and bile salt transport	GO:0015721	5	0.139
pons development	GO:0021548	13	0.138
regulation of cellular ph	GO:0030641	12	0.137
water transport	GO:0006833	12	0.132
cellular response to nutrient levels	GO:0031669	64	0.113
carboxylic acid biosynthetic process	GO:0046394	86	0.111
kidney morphogenesis	GO:0060993	83	0.110
renal tubule development	GO:0061326	87	0.107
cellular response to extracellular stimulus	GO:0031668	81	0.107
response to peptide hormone	GO:0043434	127	0.107
cellular response to fructose stimulus	GO:0071332	2	0.106
amino acid betaine transport	GO:0015838	3	0.104
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	GO:0072040	4	0.104
renal system development	GO:0072001	225	0.101
locomotory behavior	GO:0007626	195	0.099
auditory receptor cell differentiation	GO:0042491	37	0.098
organic hydroxy compound metabolic process	GO:1901615	203	0.097
hexose transport	GO:0008645	56	0.097	Rat
retina vasculature development in camera type eye	GO:0061298	17	0.094
metencephalon development	GO:0022037	89	0.093
negative regulation of stem cell maintenance	GO:1902455	4	0.092
amino acid betaine metabolic process	GO:0006577	7	0.090
regulation of potassium ion transmembrane transporter activity	GO:1901016	7	0.089
cofactor metabolic process	GO:0051186	80	0.089
response to acid chemical	GO:0001101	111	0.086
cochlear nucleus development	GO:0021747	4	0.085
regulation of ion transmembrane transporter activity	GO:0032412	54	0.083
hydrogen transport	GO:0006818	35	0.082
transcytosis	GO:0045056	5	0.080
transmission of nerve impulse	GO:0019226	76	0.079
regulation of membrane potential	GO:0042391	192	0.076
amino acid transport	GO:0006865	61	0.076
cellular response to external stimulus	GO:0071496	88	0.074
amylopectin metabolic process	GO:2000896	1	0.071
regulation of intracellular ph	GO:0051453	11	0.070
epithelial cell development	GO:0002064	159	0.069
regulation of blood pressure	GO:0008217	93	0.069
retinal cell programmed cell death	GO:0046666	8	0.068
sensory perception of light stimulus	GO:0050953	54	0.067
intestinal absorption	GO:0050892	13	0.067
dicarboxylic acid transport	GO:0006835	29	0.063
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	GO:0072039	4	0.063
cation homeostasis	GO:0055080	212	0.058
metanephric ascending thin limb development	GO:0072218	2	0.057
bicarbonate transport	GO:0015701	7	0.056
regulation of transmembrane transport	GO:0034762	128	0.054
multicellular organismal signaling	GO:0035637	91	0.054
fat cell differentiation	GO:0045444	160	0.053
cellular ketone metabolic process	GO:0042180	84	0.052
amylopectin biosynthetic process	GO:0010021	1	0.051
excretion	GO:0007588	22	0.050
cellular homeostasis	GO:0019725	240	0.050
cellular ion homeostasis	GO:0006873	165	0.049
regulation of metal ion transport	GO:0010959	106	0.048
nephron development	GO:0072006	109	0.048
regulation of cellular amino acid metabolic process	GO:0006521	5	0.046
camera type eye development	GO:0043010	266	0.045
regulation of ph	GO:0006885	26	0.045
cellular response to monosaccharide stimulus	GO:0071326	47	0.044
exploration behavior	GO:0035640	21	0.043
response to peptide	GO:1901652	136	0.043
regulation of wnt signaling pathway	GO:0030111	123	0.043
lipid biosynthetic process	GO:0008610	179	0.043
organic acid biosynthetic process	GO:0016053	86	0.042
fat soluble vitamin biosynthetic process	GO:0042362	4	0.042
glycosyl compound metabolic process	GO:1901657	246	0.042
urate transport	GO:0015747	1	0.042
retina vasculature morphogenesis in camera type eye	GO:0061299	10	0.041
hepatoblast differentiation	GO:0061017	2	0.041
carnitine transport	GO:0015879	3	0.040
pigment biosynthetic process	GO:0046148	26	0.040
sensory organ morphogenesis	GO:0090596	242	0.040
distal tubule development	GO:0072017	8	0.039
developmental growth involved in morphogenesis	GO:0060560	138	0.038
hindbrain development	GO:0030902	128	0.038
mesonephric duct morphogenesis	GO:0072180	4	0.036
visual perception	GO:0007601	52	0.036
cellular amine metabolic process	GO:0044106	44	0.036
divalent metal ion transport	GO:0070838	172	0.036
histamine transport	GO:0051608	2	0.035
epidermis development	GO:0008544	187	0.034
cellular response to osmotic stress	GO:0071470	7	0.034
metanephric loop of henle development	GO:0072236	4	0.034
regulation of secretion	GO:0051046	274	0.033
peptidyl amino acid modification	GO:0018193	336	0.033
regulation of transferase activity	GO:0051338	263	0.032
monoamine transport	GO:0015844	33	0.031
retina morphogenesis in camera type eye	GO:0060042	45	0.031
nephron tubule development	GO:0072080	84	0.031
nephron morphogenesis	GO:0072028	69	0.031
axon ensheathment	GO:0008366	76	0.031
metanephric thick ascending limb development	GO:0072233	2	0.031
insulin secretion	GO:0030073	89	0.031
intracellular protein transport	GO:0006886	204	0.030
developmental programmed cell death	GO:0010623	41	0.030
neural retina development	GO:0003407	41	0.029
metanephros development	GO:0001656	79	0.029
regulation of ion homeostasis	GO:2000021	64	0.029
organic hydroxy compound transport	GO:0015850	93	0.028
response to oxidative stress	GO:0006979	123	0.028
cellular modified amino acid metabolic process	GO:0006575	63	0.028
negative regulation of cellular protein metabolic process	GO:0032269	247	0.027
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.027
gonad development	GO:0008406	141	0.026
amine metabolic process	GO:0009308	45	0.026
regulation of mesenchymal cell apoptotic process involved in metanephros development	GO:1900211	4	0.026
response to light stimulus	GO:0009416	135	0.026
divalent inorganic cation transport	GO:0072511	178	0.026
cellular hypotonic response	GO:0071476	3	0.026
cellular response to organonitrogen compound	GO:0071417	145	0.025
glial cell differentiation	GO:0010001	131	0.025
response to starvation	GO:0042594	65	0.025
thick ascending limb development	GO:0072023	2	0.025
hair cell differentiation	GO:0035315	40	0.025
cellular response to peptide	GO:1901653	92	0.025
limb development	GO:0060173	166	0.024
ascending thin limb development	GO:0072021	2	0.024
response to organic cyclic compound	GO:0014070	198	0.024
c21 steroid hormone biosynthetic process	GO:0006700	3	0.024
mammary gland epithelium development	GO:0061180	65	0.024
regulation of hormone levels	GO:0010817	211	0.024
ensheathment of neurons	GO:0007272	76	0.024
regulation of peptide secretion	GO:0002791	77	0.024
potassium ion transmembrane transport	GO:0071805	43	0.024
response to water deprivation	GO:0009414	1	0.023
epithelial tube morphogenesis	GO:0060562	303	0.023
response to monosaccharide	GO:0034284	67	0.023
renal tubule morphogenesis	GO:0061333	72	0.023
cellular response to peptide hormone stimulus	GO:0071375	92	0.023
response to nutrient levels	GO:0031667	109	0.023
pyramidal neuron differentiation	GO:0021859	9	0.023
peptidyl serine phosphorylation	GO:0018105	74	0.022
cellular response to carbohydrate stimulus	GO:0071322	50	0.022
placenta development	GO:0001890	140	0.022
carbohydrate derivative biosynthetic process	GO:1901137	183	0.022
regulation of homeostatic process	GO:0032844	182	0.022
organ or tissue specific immune response	GO:0002251	13	0.022
regulation of protein transport	GO:0051223	163	0.022
peptide transport	GO:0015833	133	0.022
monocarboxylic acid biosynthetic process	GO:0072330	61	0.021
monocarboxylic acid transport	GO:0015718	44	0.021
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.021
camera type eye photoreceptor cell differentiation	GO:0060219	15	0.021
regulation of cellular ketone metabolic process	GO:0010565	66	0.021
l amino acid transport	GO:0015807	32	0.021
axonogenesis	GO:0007409	274	0.021
hematopoietic progenitor cell differentiation	GO:0002244	143	0.021
regulation of actin filament based process	GO:0032970	99	0.021
pigment metabolic process	GO:0042440	32	0.020
response to water	GO:0009415	1	0.020
detection of chemical stimulus involved in sensory perception of taste	GO:0050912	3	0.020
ribonucleoside metabolic process	GO:0009119	245	0.020
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	40	0.020
liver development	GO:0001889	66	0.020
cellular amino acid metabolic process	GO:0006520	103	0.020
apoptotic process involved in development	GO:1902742	28	0.020
negative regulation of neuron apoptotic process	GO:0043524	92	0.020
skin development	GO:0043588	220	0.020
response to insulin	GO:0032868	100	0.019
wnt signaling pathway	GO:0016055	188	0.019
cellular response to glucose starvation	GO:0042149	5	0.019
potassium ion homeostasis	GO:0055075	4	0.019
progesterone metabolic process	GO:0042448	4	0.019
auditory receptor cell development	GO:0060117	20	0.019
positive regulation of apoptotic process	GO:0043065	217	0.019
male gamete generation	GO:0048232	285	0.019
regulation of peptide transport	GO:0090087	91	0.019
regulation of potassium ion transport	GO:0043266	16	0.019
nucleoside triphosphate metabolic process	GO:0009141	230	0.018
morphogenesis of a branching structure	GO:0001763	203	0.018
regulation of kinase activity	GO:0043549	249	0.018
reactive oxygen species metabolic process	GO:0072593	84	0.018
nephron epithelium morphogenesis	GO:0072088	68	0.018
response to growth factor	GO:0070848	198	0.017
negative regulation of mesenchymal cell apoptotic process involved in metanephros development	GO:1900212	4	0.017
protein targeting	GO:0006605	143	0.017
regulation of ion transmembrane transport	GO:0034765	119	0.017
cellular response to starvation	GO:0009267	57	0.017
organonitrogen compound biosynthetic process	GO:1901566	192	0.017
cell junction assembly	GO:0034329	52	0.017
negative regulation of protein transport	GO:0051224	46	0.017
negative regulation of protein phosphorylation	GO:0001933	126	0.017
sulfur compound metabolic process	GO:0006790	100	0.017
metal ion homeostasis	GO:0055065	189	0.017
regulation of pancreatic juice secretion	GO:0090186	4	0.017
synaptic transmission	GO:0007268	329	0.017
regulation of purine nucleotide metabolic process	GO:1900542	169	0.017
cellular response to abiotic stimulus	GO:0071214	56	0.017
cellular response to insulin stimulus	GO:0032869	78	0.016
cell substrate adhesion	GO:0031589	130	0.016
peptidyl tyrosine phosphorylation	GO:0018108	143	0.016
ribose phosphate metabolic process	GO:0019693	291	0.016
regulation of secretion by cell	GO:1903530	249	0.016
mechanoreceptor differentiation	GO:0042490	67	0.016
positive regulation of cell death	GO:0010942	224	0.016
regulation of cellular amine metabolic process	GO:0033238	20	0.016
positive regulation of potassium ion transport	GO:0043268	3	0.016
neurotransmitter transport	GO:0006836	76	0.016
epithelial tube formation	GO:0072175	130	0.016
protein autophosphorylation	GO:0046777	61	0.016
cofactor biosynthetic process	GO:0051188	41	0.015
cognition	GO:0050890	149	0.015
negative regulation of hormone metabolic process	GO:0032351	4	0.015
limb morphogenesis	GO:0035108	149	0.015
neural nucleus development	GO:0048857	22	0.015
regulation of peptide hormone secretion	GO:0090276	75	0.015
synaptic vesicle localization	GO:0097479	59	0.015
chromatin organization	GO:0006325	206	0.015
peptide secretion	GO:0002790	114	0.015
organelle localization	GO:0051640	179	0.014
fatty acid metabolic process	GO:0006631	121	0.014
multicellular organismal homeostasis	GO:0048871	164	0.014
hepaticobiliary system development	GO:0061008	67	0.014
regulation of transporter activity	GO:0032409	57	0.014
negative regulation of stem cell differentiation	GO:2000737	14	0.014
regulation of protein localization	GO:0032880	231	0.014
regulation of neuronal synaptic plasticity	GO:0048168	30	0.014
embryonic appendage morphogenesis	GO:0035113	126	0.014
amide transport	GO:0042886	138	0.014
positive regulation of protein modification process	GO:0031401	299	0.014
protein localization to organelle	GO:0033365	185	0.013
positive regulation of blood pressure	GO:0045777	21	0.013
metanephric nephron tubule development	GO:0072234	16	0.013
regulation of inflammatory response	GO:0050727	147	0.013
forebrain development	GO:0030900	302	0.013
organophosphate catabolic process	GO:0046434	232	0.013
asymmetric stem cell division	GO:0098722	3	0.013
nucleoside phosphate metabolic process	GO:0006753	338	0.013
morphogenesis of embryonic epithelium	GO:0016331	159	0.013
tube formation	GO:0035148	140	0.013
cellular response to cytokine stimulus	GO:0071345	189	0.013
response to extracellular stimulus	GO:0009991	127	0.013
negative regulation of secretion	GO:0051048	61	0.013
nucleoside phosphate catabolic process	GO:1901292	222	0.013
norepinephrine secretion	GO:0048243	2	0.013
inner ear receptor cell development	GO:0060119	39	0.013
regulation of systemic arterial blood pressure	GO:0003073	61	0.013
carbohydrate derivative catabolic process	GO:1901136	231	0.013
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.013
negative regulation of protein modification process	GO:0031400	163	0.013
regulation of establishment of protein localization	GO:0070201	181	0.013
alcohol metabolic process	GO:0006066	116	0.013
cellular response to growth factor stimulus	GO:0071363	197	0.013
gliogenesis	GO:0042063	141	0.013
regulation of potassium ion transmembrane transport	GO:1901379	11	0.013
small gtpase mediated signal transduction	GO:0007264	97	0.012
aromatic compound catabolic process	GO:0019439	286	0.012
purine ribonucleoside metabolic process	GO:0046128	241	0.012
mesonephric duct formation	GO:0072181	2	0.012
bone remodeling	GO:0046849	53	0.012
heterocycle catabolic process	GO:0046700	280	0.012
metanephric distal convoluted tubule development	GO:0072221	5	0.012
regulation of defense response	GO:0031347	233	0.012
engulfment of apoptotic cell	GO:0043652	3	0.012
peptidyl serine modification	GO:0018209	83	0.012
lipid transport	GO:0006869	98	0.012
negative regulation of cell development	GO:0010721	169	0.012
cellular lipid metabolic process	GO:0044255	323	0.012
defense response to virus	GO:0051607	68	0.012
modified amino acid transport	GO:0072337	5	0.012
photoreceptor cell development	GO:0042461	40	0.012
lipid localization	GO:0010876	126	0.012
chromatin modification	GO:0016568	187	0.012
lymphocyte mediated immunity	GO:0002449	139	0.012
body fluid secretion	GO:0007589	53	0.012
purine nucleotide metabolic process	GO:0006163	302	0.012
porphyrin containing compound biosynthetic process	GO:0006779	16	0.011
response to inorganic substance	GO:0010035	96	0.011
positive regulation of cellular amine metabolic process	GO:0033240	5	0.011
brain morphogenesis	GO:0048854	32	0.011
regulation of cellular component biogenesis	GO:0044087	181	0.011
purine ribonucleoside catabolic process	GO:0046130	205	0.011
nephron tubule morphogenesis	GO:0072078	68	0.011
response to vitamin d	GO:0033280	3	0.011
mammary gland morphogenesis	GO:0060443	54	0.011
l glutamate uptake involved in synaptic transmission	GO:0051935	3	0.011
methylation	GO:0032259	134	0.011
cellular nitrogen compound catabolic process	GO:0044270	280	0.011
activation of janus kinase activity	GO:0042976	2	0.011
regulation of neurotransmitter levels	GO:0001505	87	0.011
branching morphogenesis of an epithelial tube	GO:0048754	159	0.011
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.011
cell matrix adhesion	GO:0007160	68	0.011
germ line stem cell division	GO:0042078	2	0.011
guanosine containing compound metabolic process	GO:1901068	144	0.011
forebrain neuron development	GO:0021884	30	0.011
regulation of neuron apoptotic process	GO:0043523	122	0.011
nucleotide metabolic process	GO:0009117	332	0.010
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.010
reactive nitrogen species metabolic process	GO:2001057	0	0.010
somatic stem cell maintenance	GO:0035019	47	0.010
negative regulation of pancreatic juice secretion	GO:0090188	3	0.010
cellular potassium ion transport	GO:0071804	43	0.010
development of primary sexual characteristics	GO:0045137	143	0.010
forebrain generation of neurons	GO:0021872	63	0.010
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.010
guanosine containing compound catabolic process	GO:1901069	144	0.010
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.010
appendage morphogenesis	GO:0035107	149	0.010
metanephric tubule development	GO:0072170	18	0.010
protein import	GO:0017038	101	0.010
gland development	GO:0048732	330	0.010
positive regulation of hydrolase activity	GO:0051345	148	0.010
regulation of hormone secretion	GO:0046883	88	0.010
protein modification by small protein conjugation or removal	GO:0070647	207	0.010
regulation of inward rectifier potassium channel activity	GO:1901979	1	0.010

Slc5a2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.154
cancer	DOID:162	0.100
disease of metabolism	DOID:0014667	0.093
organ system cancer	DOID:0050686	0.051
acquired metabolic disease	DOID:0060158	0.019
disease of anatomical entity	DOID:7	0.017
urinary system disease	DOID:18	0.017
kidney disease	DOID:557	0.017
inherited metabolic disorder	DOID:655	0.016
renal carcinoma	DOID:4451	0.015
kidney cancer	DOID:263	0.015
urinary system cancer	DOID:3996	0.015
renal cell carcinoma	DOID:4450	0.015
musculoskeletal system disease	DOID:17	0.012
type 1 diabetes mellitus	DOID:9744	0.011
carbohydrate metabolism disease	DOID:0050013	0.011
diabetes mellitus	DOID:9351	0.011
glucose metabolism disease	DOID:4194	0.011

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