Mus musculus

269 known processes

Smad3

MAD homolog 3 (Drosophila)

(Aliases: Madh3,AU022421)

Smad3 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of smad protein import into nucleusGO:006039031.000
Mouse
metanephric mesenchyme morphogenesisGO:007213341.000
Mouse
negative regulation of osteoblast proliferationGO:003368941.000
nephrogenic mesenchyme morphogenesisGO:007213420.999
Mouse
negative regulation of peptidyl serine phosphorylationGO:0033137100.999
Mouse
cell proliferation involved in heart valve morphogenesisGO:000324910.999
Mouse
kidney mesenchyme morphogenesisGO:007213140.998
Mouse
endothelial cell activationGO:004211810.998
Mouse
epithelial tube morphogenesisGO:00605623030.997
peptidyl threonine modificationGO:0018210310.997
Mouse
regulation of peptidyl serine phosphorylationGO:0033135390.996
Mouse
peptidyl threonine phosphorylationGO:0018107310.996
Mouse
negative regulation of peptidyl threonine phosphorylationGO:001080160.995
Mouse
blood vessel morphogenesisGO:00485142850.995
Mouse
digestive tract developmentGO:00485651900.995
heart morphogenesisGO:00030071780.994
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.993
bmp signaling pathwayGO:0030509930.991
Mouse
branching morphogenesis of an epithelial tubeGO:00487541590.991
Mouse
negative regulation of cellular amine metabolic processGO:003323910.990
positive regulation of cell proliferation involved in heart valve morphogenesisGO:000325110.990
Mouse
regulation of muscle system processGO:0090257800.987
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulusGO:190152270.985
Mouse
regulation of protein import into nucleusGO:0042306520.985
Human Mouse
germ line stem cell divisionGO:004207820.984
cell fate commitmentGO:00451652100.982
Mouse
positive regulation of cell developmentGO:00107202370.982
Human Mouse
negative regulation of bmp signaling pathwayGO:0030514350.981
Mouse
negative regulation of cell proliferationGO:00082852960.981
axon guidanceGO:00074111410.980
Mouse
positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902043130.980
regulation of neuron differentiationGO:00456642810.979
bone developmentGO:00603481200.979
Mouse
negative regulation of cellular amino acid metabolic processGO:004576300.978
cell adhesionGO:00071553290.977
Mouse Rat
transforming growth factor beta receptor signaling pathwayGO:0007179710.977
lens development in camera type eyeGO:0002088620.976
negative regulation of cell developmentGO:00107211690.975
germline cell cycle switching mitotic to meiotic cell cycleGO:005172910.974
Worm
regulation of cell proliferation involved in heart valve morphogenesisGO:000325010.974
Mouse
urogenital system developmentGO:00016552610.973
myeloid cell differentiationGO:00300992330.972
Mouse
positive regulation of apoptotic processGO:00430652170.972
Human Rat
activin receptor signaling pathwayGO:0032924180.972
Human
mesendoderm developmentGO:004838230.972
nephrogenic mesenchyme developmentGO:007207630.970
Mouse
cardiac muscle tissue developmentGO:00487381300.970
Mouse
chemotaxisGO:00069352470.969
Mouse Rat
digestive tract morphogenesisGO:00485461470.969
positive regulation of nervous system developmentGO:00519622210.969
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.969
cartilage developmentGO:00512161400.968
connective tissue developmentGO:00614481790.968
forebrain developmentGO:00309003020.968
embryonic organ morphogenesisGO:00485622760.968
digestive system developmentGO:00551232000.966
cardiac endothelial cell differentiationGO:000334840.963
Mouse
mesonephric tubule developmentGO:0072164940.962
cell proliferation involved in heart valve developmentGO:200079320.961
Mouse
dna metabolic processGO:00062593030.960
striated muscle tissue developmentGO:00147062930.960
positive regulation of smad protein import into nucleusGO:006039120.960
Mouse
endocardial cushion formationGO:0003272130.959
Mouse
segmentationGO:0035282930.959
mammary gland morphogenesisGO:0060443540.959
brainstem developmentGO:000336030.957
Mouse
positive regulation of cell morphogenesis involved in differentiationGO:0010770720.957
Human Mouse
regulation of cartilage developmentGO:0061035440.954
muscle cell proliferationGO:0033002520.952
Mouse
regulation of epithelial cell proliferationGO:00506781410.952
regulation of protein kinase activityGO:00458592320.950
angiogenesisGO:00015252010.950
stem cell developmentGO:00488642190.950
Human Mouse
leukocyte differentiationGO:00025213420.949
regulation of cell adhesionGO:00301551540.947
Mouse Rat
peptidyl amino acid modificationGO:00181933360.947
Mouse
positive regulation of apoptotic process involved in mammary gland involutionGO:006005840.945
camera type eye developmentGO:00430102660.944
regulation of bmp signaling pathwayGO:0030510600.941
Mouse
regulation of osteoblast differentiationGO:0045667670.939
protein localization to nucleusGO:00345041210.939
Human Mouse
epithelial to mesenchymal transition involved in endocardial cushion formationGO:0003198100.934
Mouse
regionalizationGO:00030023370.932
nephron tubule morphogenesisGO:0072078680.932
Mouse
endoderm developmentGO:0007492450.932
regulation of hydrolase activityGO:00513362460.931
Human Rat
negative regulation of phosphorylationGO:00423261660.930
Human Mouse
endocrine system developmentGO:0035270980.930
negative regulation of nervous system developmentGO:00519611560.929
nitrogen compound transportGO:00717052710.928
Mouse
response to sterolGO:003631440.927
appendage developmentGO:00487361660.924
muscle system processGO:00030121410.924
Mouse
embryonic heart tube developmentGO:0035050650.923
nephron epithelium morphogenesisGO:0072088680.921
Mouse
cellular response to growth factor stimulusGO:00713631970.921
regulation of osteoblast proliferationGO:0033688150.919
positive regulation of leukocyte differentiationGO:1902107860.919
mesenchymal cell developmentGO:0014031930.919
Human Mouse
regulation of transferase activityGO:00513382630.918
positive regulation of neuron differentiationGO:00456661410.917
regulation of protein serine threonine kinase activityGO:00719001570.915
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.915
regulation of transforming growth factor beta receptor signaling pathwayGO:0017015430.913
response to peptide hormoneGO:00434341270.913
hair follicle developmentGO:0001942850.912
Mouse
mapk cascadeGO:00001652810.911
Mouse
osteoblast fate commitmentGO:000205140.911
Mouse
cellular response to transforming growth factor beta stimulusGO:0071560880.911
regulation of peptidyl tyrosine phosphorylationGO:0050730930.909
response to growth factorGO:00708481980.908
regulation of response to woundingGO:19030341890.907
nephron tubule developmentGO:0072080840.906
Mouse
pathway restricted smad protein phosphorylationGO:0060389100.905
Mouse
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetryGO:190016420.902
neural tube developmentGO:00219151600.901
positive regulation of apoptotic signaling pathwayGO:2001235950.900
Rat
positive regulation of stem cell differentiationGO:2000738230.900
Human Mouse
mesodermal cell fate commitmentGO:0001710170.899
Mouse
negative regulation of phosphorus metabolic processGO:00105631840.896
Human Mouse
peptide transportGO:00158331330.896
Mouse
ossificationGO:00015032160.895
inflammatory responseGO:00069542440.891
negative regulation of phosphate metabolic processGO:00459361840.888
Human Mouse
axonogenesisGO:00074092740.888
Mouse
striated muscle cell proliferationGO:0014855390.886
Mouse
t cell activationGO:00421102890.886
wound healingGO:00420601570.886
hindbrain developmentGO:00309021280.884
Mouse
regulation of organ morphogenesisGO:20000271440.883
Mouse
muscle cell developmentGO:00550011330.882
negative regulation of cell growthGO:0030308440.880
Human
negative regulation of protein phosphorylationGO:00019331260.880
Human Mouse
regulation of kinase activityGO:00435492490.878
morphogenesis of a branching epitheliumGO:00611381930.877
Mouse
female gamete generationGO:0007292740.874
nodal signaling pathway involved in determination of left right asymmetryGO:003810720.871
fibroblast migrationGO:0010761210.870
gland developmentGO:00487323300.868
establishment of protein localization to organelleGO:00725941180.866
Human Mouse
somitogenesisGO:0001756690.866
neuron projection guidanceGO:00974851410.865
Mouse
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetryGO:190009420.864
peptidyl tyrosine phosphorylationGO:00181081430.861
embryonic epithelial tube formationGO:00018381300.861
cellular macromolecule catabolic processGO:00442652060.861
positive regulation of programmed cell deathGO:00430682180.859
Human Rat
morphogenesis of a branching structureGO:00017632030.858
Mouse
regulation of chondrocyte differentiationGO:0032330330.858
kidney developmentGO:00018222130.857
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332350.857
cellular amino acid metabolic processGO:00065201030.855
embryonic skeletal system morphogenesisGO:0048704910.855
positive regulation of cell adhesionGO:0045785800.854
Mouse Rat
placenta developmentGO:00018901400.854
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.852
mesonephric tubule morphogenesisGO:0072171630.850
Mouse
endochondral bone morphogenesisGO:0060350500.847
regulation of neuron projection developmentGO:00109751690.846
regulation of vasculature developmentGO:1901342880.845
negative regulation of angiogenesisGO:0016525250.845
positive regulation of epithelial to mesenchymal transitionGO:0010718130.845
Human Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090100430.843
Mouse
gastrulationGO:00073691160.840
regulation of bindingGO:00510981110.838
regulation of myeloid cell differentiationGO:0045637960.837
regulation of cell migrationGO:00303342190.836
Rat
regulation of cell activationGO:00508652890.836
pallium developmentGO:00215431200.835
somite developmentGO:0061053810.835
chondrocyte differentiationGO:0002062720.834
t cell differentiationGO:00302171740.832
maternal process involved in female pregnancyGO:0060135320.832
positive regulation of bmp signaling pathwayGO:0030513230.827
stem cell differentiationGO:00488632680.826
Human Mouse
positive regulation of mammary gland involutionGO:190352140.826
muscle tissue morphogenesisGO:0060415530.825
Mouse
cytoplasmic transportGO:00164822340.819
Human Mouse
nuclear transportGO:00511691390.816
Human Mouse
cellular amine metabolic processGO:0044106440.816
regulation of cellular amino acid metabolic processGO:000652150.814
regulation of cellular response to growth factor stimulusGO:0090287820.813
positive regulation of intracellular transportGO:0032388700.812
Human Mouse
peptide secretionGO:00027901140.812
Mouse
limb morphogenesisGO:00351081490.811
response to organic cyclic compoundGO:00140701980.809
Mouse
positive regulation of transforming growth factor beta receptor signaling pathwayGO:0030511120.809
positive regulation of cell activationGO:00508671580.807
stem cell maintenanceGO:00198271300.806
regulation of hormone levelsGO:00108172110.806
Mouse
branching involved in ureteric bud morphogenesisGO:0001658560.805
Mouse
regulation of mapk cascadeGO:00434082480.805
negative regulation of protein metabolic processGO:00512482820.805
Human Mouse
wnt signaling pathwayGO:00160551880.803
Human
telencephalon developmentGO:00215371860.802
erythrocyte differentiationGO:0030218880.801
Mouse
regulation of intracellular protein transportGO:0033157820.798
Human Mouse
regulation of epithelial to mesenchymal transitionGO:0010717220.798
Human Mouse
response to cholesterolGO:007072340.795
nephron epithelium developmentGO:0072009920.795
Mouse
regulation of angiogenesisGO:0045765810.795
response to nutrient levelsGO:00316671090.791
renal tubule morphogenesisGO:0061333720.788
Mouse
respiratory tube developmentGO:00303231670.788
Mouse
extrinsic apoptotic signaling pathwayGO:00971911260.786
Human
metanephros developmentGO:0001656790.786
Mouse
negative regulation of epithelial cell proliferationGO:0050680640.786
response to transforming growth factor betaGO:0071559880.785
amide transportGO:00428861380.785
Mouse
mesenchymal cell differentiationGO:00487621070.782
Human Mouse
myeloid leukocyte differentiationGO:00025731190.781
regulation of stem cell differentiationGO:2000736500.780
Human Mouse
metencephalon developmentGO:0022037890.779
regulation of cell morphogenesis involved in differentiationGO:00107691510.777
Human Mouse
regulation of ossificationGO:00302781120.774
positive regulation of neuron projection developmentGO:0010976790.773
epidermis developmentGO:00085441870.769
Mouse
neural tube formationGO:00018411080.768
t cell differentiation in thymusGO:0033077770.766
g protein coupled receptor signaling pathwayGO:00071862430.764
fat cell differentiationGO:00454441600.764
smad protein complex assemblyGO:000718310.758
Human Rat
ureteric bud morphogenesisGO:0060675620.758
Mouse
lung developmentGO:00303241640.755
Mouse
nucleocytoplasmic transportGO:00069131390.755
Human Mouse
negative regulation of cellular protein metabolic processGO:00322692470.755
Human Mouse
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.754
regulation of heart contractionGO:0008016770.752
Mouse
regulation of pathway restricted smad protein phosphorylationGO:006039360.748
Mouse
negative regulation of protein modification processGO:00314001630.746
Human Mouse
appendage morphogenesisGO:00351071490.745
engulfment of apoptotic cellGO:004365230.745
regulation of wound healingGO:0061041400.744
molting cycleGO:0042303900.743
Mouse
negative regulation of defense responseGO:0031348770.741
regulation of cell growthGO:0001558910.734
Human
multicellular organism growthGO:00352641610.734
Worm
positive regulation of glial cell proliferationGO:006025240.730
male sex differentiationGO:00466611090.729
Worm
positive regulation of map kinase activityGO:0043406840.725
chondrocyte developmentGO:0002063240.723
tyrosine phosphorylation of stat1 proteinGO:004250830.722
positive regulation of behaviorGO:0048520400.721
Rat
response to radiationGO:00093141650.718
sebaceous gland developmentGO:004873370.718
Mouse
ureteric bud developmentGO:0001657940.716
midbrain developmentGO:0030901350.712
Mouse
amine metabolic processGO:0009308450.712
cell cycle switchingGO:006018410.711
Worm
hormone secretionGO:00468791280.711
Mouse
positive regulation of neuron projection regenerationGO:007057220.705
canonical wnt signaling pathway involved in negative regulation of apoptotic processGO:004433640.705
positive regulation of cell deathGO:00109422240.702
Human Rat
negative regulation of cell cycleGO:00457861230.700
Human Worm
nephron morphogenesisGO:0072028690.698
Mouse
embryonic skeletal system developmentGO:00487061200.697
neural tube closureGO:0001843900.697
cytokine productionGO:00018163190.695
Human Rat
extracellular matrix organizationGO:00301981470.695
Human
positive regulation of cell proliferation involved in heart morphogenesisGO:200013850.695
Mouse
palate developmentGO:0060021760.694
Mouse
developmental growth involved in morphogenesisGO:00605601380.694
canonical wnt signaling pathwayGO:00600701300.689
Human
regulation of striated muscle contractionGO:0006942250.688
Mouse
response to monosaccharideGO:0034284670.688
Mouse
central nervous system neuron differentiationGO:00219531620.688
multi multicellular organism processGO:00447061090.684
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.684
skeletal system developmentGO:00015013560.684
antral ovarian follicle growthGO:000154750.682
neural precursor cell proliferationGO:00613511210.682
protein import into nucleusGO:0006606950.680
Human Mouse
regulation of peptidyl threonine phosphorylationGO:0010799120.680
Mouse
positive regulation of protein phosphorylationGO:00019342420.680
Mouse
cardiac muscle tissue morphogenesisGO:0055008440.675
Mouse
mesenchyme morphogenesisGO:0072132320.673
learning or memoryGO:00076111480.672
peptidyl serine modificationGO:0018209830.668
Mouse
female sex differentiationGO:0046660840.668
germ cell developmentGO:00072811850.667
Mouse
positive regulation of notch signaling pathwayGO:0045747180.666
regulation of muscle tissue developmentGO:1901861970.660
stem cell divisionGO:0017145300.660
negative regulation of inflammatory responseGO:0050728610.658
regulation of mammary gland involutionGO:190351940.656
mesenchyme developmentGO:00604851520.655
negative regulation of blood vessel morphogenesisGO:2000181250.652
regulation of endopeptidase activityGO:0052548890.636
Human Rat
protein targetingGO:00066051430.635
Human Mouse
negative regulation of osteoblast differentiationGO:0045668300.635
positive regulation of cell cycleGO:0045787920.634
Worm
embryonic heart tube morphogenesisGO:0003143510.633
positive regulation of protein serine threonine kinase activityGO:00719021060.632
outflow tract morphogenesisGO:0003151530.632
positive regulation of cell projection organizationGO:0031346950.623
nuclear importGO:0051170950.622
Human Mouse
positive regulation of protein import into nucleusGO:0042307260.621
Human Mouse
positive t cell selectionGO:0043368230.621
regulation of feeding behaviorGO:006025930.619
apoptotic signaling pathwayGO:00971903060.617
Human Rat
developmental maturationGO:00217001930.617
stem cell proliferationGO:00720891170.617
mesonephric epithelium developmentGO:0072163940.616
positive regulation of myeloid cell differentiationGO:0045639430.616
blastoderm segmentationGO:0007350130.613
organ growthGO:00352651170.613
Mouse
regulation of activin receptor signaling pathwayGO:0032925100.609
cell fate determinationGO:0001709320.606
lymphocyte differentiationGO:00300982420.606
membrane organizationGO:00610242450.605
endocardial cell differentiationGO:006095640.605
Mouse
ventricular septum developmentGO:0003281420.605
Mouse
luteinizationGO:000155380.602
mesoderm morphogenesisGO:0048332640.601
positive regulation of chemotaxisGO:0050921380.600
Rat
protein importGO:00170381010.597
Human Mouse
cardiac chamber morphogenesisGO:0003206930.597
Mouse
sensory organ morphogenesisGO:00905962420.595
single organism nuclear importGO:1902593950.595
Human Mouse
formation of primary germ layerGO:0001704770.595
cartilage development involved in endochondral bone morphogenesisGO:0060351240.595
lateral mesoderm formationGO:004837030.590
regulation of cell cycleGO:00517262810.586
Human Worm
renal tubule developmentGO:0061326870.583
Mouse
carbohydrate metabolic processGO:00059752300.582
ameboidal type cell migrationGO:00016671280.581
muscle contractionGO:00069361010.578
Mouse
cardiac chamber developmentGO:00032051080.577
Mouse
lateral mesoderm morphogenesisGO:004836930.576
morphogenesis of embryonic epitheliumGO:00163311590.576
response to alcoholGO:0097305480.575
embryonic placenta developmentGO:0001892980.574
regulation of myeloid leukocyte differentiationGO:0002761580.572
positive regulation of protein kinase activityGO:00458601440.567
positive regulation of protein modification processGO:00314012990.567
Mouse
positive regulation of cellular amino acid metabolic processGO:004576430.565
cardiac muscle tissue growthGO:0055017370.565
Mouse
cellular response to peptideGO:1901653920.563
positive regulation of myeloid leukocyte differentiationGO:0002763260.559
mesonephros developmentGO:0001823970.558
response to granulocyte macrophage colony stimulating factorGO:009701230.558
cardiac epithelial to mesenchymal transitionGO:0060317180.555
Mouse
hepaticobiliary system developmentGO:0061008670.549
tissue regenerationGO:0042246220.547
bone morphogenesisGO:0060349780.547
negative regulation of growthGO:0045926990.546
Human
retina development in camera type eyeGO:00600411190.546
determination of left right symmetryGO:0007368800.546
ventricular septum morphogenesisGO:0060412270.545
Mouse
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.544
Mouse
organonitrogen compound catabolic processGO:19015652640.541
positive regulation of cellular amine metabolic processGO:003324050.539
negative regulation of endothelial cell differentiationGO:004560220.537
regulation of cell substrate adhesionGO:0010810730.536
Rat
renal system developmentGO:00720012250.533
muscle tissue developmentGO:00605373080.532
single organismal cell cell adhesionGO:00163371310.531
Mouse
regulation of melanocyte differentiationGO:004563470.529
regulation of anti mullerian hormone signaling pathwayGO:190261210.529
epithelial tube formationGO:00721751300.529
cellular response to alcoholGO:0097306230.529
negative regulation of transforming growth factor beta receptor signaling pathwayGO:0030512260.528
positive regulation of cytoplasmic transportGO:1903651400.526
Human Mouse
cartilage condensationGO:0001502180.525
male gonad developmentGO:0008584880.523
myeloid cell homeostasisGO:00022621140.522
Mouse
regulation of rho protein signal transductionGO:0035023710.522
negative regulation of wound healingGO:0061045140.515
regulation of apoptotic signaling pathwayGO:20012331970.515
Rat
regulation of fibroblast proliferationGO:0048145340.514
protein maturationGO:00516041760.511
Human Rat
cell type specific apoptotic processGO:00972852680.511
positive regulation of epithelial cell migrationGO:0010634190.510
formation of anatomical boundaryGO:004885960.506
Mouse
trachea formationGO:006044030.506
regulation of axon extensionGO:0030516430.505
regulation of transforming growth factor beta2 productionGO:003290920.504
Human
respiratory system developmentGO:00605411900.500
Mouse
fused antrum stageGO:004816510.500
synaptic transmissionGO:00072683290.499
insulin secretionGO:0030073890.498
Mouse
energy reserve metabolic processGO:0006112390.494
regulation of protein bindingGO:0043393600.494
regulation of purine nucleotide metabolic processGO:19005421690.494
trophectodermal cellular morphogenesisGO:000183130.493
tube formationGO:00351481400.492
regulation of muscle contractionGO:0006937490.490
Mouse
regulation of t cell activationGO:00508631700.490
signal transduction by p53 class mediatorGO:0072331510.489
positive regulation of alpha beta t cell differentiationGO:0046638280.488
rho protein signal transductionGO:0007266320.488
circulatory system processGO:00030131970.488
Mouse
regenerationGO:0031099380.487
progesterone metabolic processGO:004244840.486
development of primary female sexual characteristicsGO:0046545730.484
endocardium developmentGO:0003157100.482
Mouse
regulation of nucleotide metabolic processGO:00061401690.482
muscle cell differentiationGO:00426922610.476
regulation of reactive oxygen species biosynthetic processGO:190342620.476
determination of heart left right asymmetryGO:0061371480.475
common partner smad protein phosphorylationGO:000718220.474
negative regulation of cyclin dependent protein serine threonine kinase activityGO:004573690.472
ovulation cycleGO:0042698590.470
cardiac septum developmentGO:0003279590.469
Mouse
cellular homeostasisGO:00197252400.468
generation of precursor metabolites and energyGO:00060911030.462
regulation of protein targetingGO:1903533610.461
Human Mouse
regulation of alpha beta t cell differentiationGO:0046637350.461
development of primary sexual characteristicsGO:00451371430.460
positive regulation of activin receptor signaling pathwayGO:003292730.459
regulation of protein localization to nucleusGO:1900180600.459
Human Mouse
regulation of ras protein signal transductionGO:00465781140.458
response to inorganic substanceGO:0010035960.458
atrioventricular valve morphogenesisGO:0003181130.457
Mouse
maternal placenta developmentGO:0001893200.456
peptide hormone secretionGO:00300721090.455
Mouse
negative regulation of molecular functionGO:00440922580.455
positive regulation of cartilage developmentGO:0061036180.455
negative regulation of glycolytic processGO:004582040.453
response to amino acidGO:0043200370.453
cellular response to inorganic substanceGO:0071241370.453
apoptotic process involved in mammary gland involutionGO:006005740.453
regulation of blood circulationGO:1903522930.450
Mouse
biomineral tissue developmentGO:0031214640.449
Rat
activation of mapk activityGO:0000187590.449
heart field specificationGO:000312860.449
release of cytochrome c from mitochondriaGO:0001836230.449
lateral mesodermal cell differentiationGO:004837130.447
proteolysis involved in cellular protein catabolic processGO:00516031470.446
regulation of cell proliferation involved in heart morphogenesisGO:2000136150.444
Mouse
regulation of blood vessel endothelial cell migrationGO:0043535120.444
oxidation reduction processGO:00551143420.443
positive regulation of t cell activationGO:00508701010.443
tissue remodelingGO:00487711020.442
smad protein import into nucleusGO:000718460.442
Mouse
heart valve morphogenesisGO:0003179210.440
Mouse
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.439
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.439
Human Rat
reactive nitrogen species metabolic processGO:200105700.439
tolerance induction to self antigenGO:000251340.439
positive regulation of mitochondrial membrane permeability involved in apoptotic processGO:1902110110.434
oogenesisGO:0048477560.434
blastocyst developmentGO:0001824800.433
osteoblast developmentGO:0002076170.431
regulation of synaptic growth at neuromuscular junctionGO:000858240.431
embryonic limb morphogenesisGO:00303261260.431
intracellular receptor signaling pathwayGO:0030522740.431
response to peptideGO:19016521360.430
gonad developmentGO:00084061410.430
regulation of nucleocytoplasmic transportGO:0046822730.430
Human Mouse
spermatid differentiationGO:00485151150.428
genetic imprintingGO:0071514270.427
regulation of cellular catabolic processGO:00313292420.427
embryonic digit morphogenesisGO:0042733560.425
endothelial cell differentiationGO:0045446410.424
Mouse
regulation of reproductive processGO:2000241660.422
dendrite developmentGO:00163581150.421
energy derivation by oxidation of organic compoundsGO:0015980770.421
regulation of notch signaling pathwayGO:0008593350.421
regulation of tyrosine phosphorylation of stat1 proteinGO:004251020.419
primary neural tube formationGO:0014020950.419
negative regulation of immune system processGO:00026832090.419
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.418
regulation of b cell tolerance inductionGO:000266120.417
regulation of meiotic cell cycleGO:0051445340.417
Worm
cellular response to organonitrogen compoundGO:00714171450.416
development of primary male sexual characteristicsGO:0046546880.416
skeletal system morphogenesisGO:00487052030.415
cardiac septum morphogenesisGO:0060411460.411
Mouse
neuronal action potentialGO:0019228540.411
regulation of cellular response to stressGO:00801351590.410
negative regulation of neuron migrationGO:200122360.409
regulation of epidermis developmentGO:0045682330.409
Mouse
epithelial cell proliferationGO:00506731740.407
asymmetric neuroblast divisionGO:005505910.407
kidney morphogenesisGO:0060993830.405
Mouse
regulation of map kinase activityGO:00434051200.403
cellular ketone metabolic processGO:0042180840.403
negative regulation of response to woundingGO:1903035770.401
positive regulation of cell motilityGO:20001471160.400
Rat
response to inactivityGO:001485440.399
cellular divalent inorganic cation homeostasisGO:00725031270.399
striated muscle cell developmentGO:00550021250.398
positive regulation of osteoblast differentiationGO:0045669340.395
Mouse
protein localization to organelleGO:00333651850.394
Human Mouse
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436230.392
female gonad developmentGO:0008585710.391
labyrinthine layer morphogenesisGO:0060713210.390
regulation of protein stabilityGO:0031647520.389
Human
regulation of cellular senescenceGO:200077260.388
keratinocyte migrationGO:005154630.387
regulation of endothelial cell differentiationGO:0045601100.385
response to insulinGO:00328681000.383

Smad3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.942
cancerDOID:16200.735
disease of anatomical entityDOID:700.668
musculoskeletal system diseaseDOID:1700.668
connective tissue diseaseDOID:6500.668
organ system cancerDOID:005068600.552