Mus musculus

371 known processes

Smad4

MAD homolog 4 (Drosophila)

(Aliases: AW743858,D18Wsu70e,Madh4,DPC4)

Smad4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cell proliferation involved in heart valve morphogenesisGO:000324911.000
nephrogenic mesenchyme morphogenesisGO:007213421.000
kidney mesenchyme morphogenesisGO:007213141.000
metanephric mesenchyme morphogenesisGO:007213341.000
endothelial cell activationGO:004211811.000
germline cell cycle switching mitotic to meiotic cell cycleGO:005172911.000
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulusGO:190152271.000
Mouse
positive regulation of cell proliferation involved in heart valve morphogenesisGO:000325111.000
negative regulation of peptidyl threonine phosphorylationGO:001080161.000
Mouse
germ line stem cell divisionGO:004207821.000
Fly
epithelial to mesenchymal transition involved in endocardial cushion formationGO:0003198101.000
negative regulation of peptidyl serine phosphorylationGO:0033137101.000
Mouse
cell proliferation involved in heart valve developmentGO:200079321.000
digestive system developmentGO:00551232001.000
response to sterolGO:003631441.000
digestive tract developmentGO:00485651901.000
brainstem developmentGO:000336031.000
digestive tract morphogenesisGO:00485461470.999
osteoblast fate commitmentGO:000205140.999
Mouse
negative regulation of osteoblast proliferationGO:003368940.999
Mouse
regulation of cell proliferation involved in heart valve morphogenesisGO:000325010.999
gastrulationGO:00073691160.998
cell cycle switching mitotic to meiotic cell cycleGO:005172810.998
t cell activationGO:00421102890.998
Mouse
cell cycle switchingGO:006018410.998
positive regulation of smad protein import into nucleusGO:006039120.998
osteoblast developmentGO:0002076170.998
Mouse
regulation of cell adhesionGO:00301551540.995
Mouse
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.995
Fly
negative regulation of cell cycleGO:00457861230.995
positive regulation of stem cell differentiationGO:2000738230.994
nephrogenic mesenchyme developmentGO:007207630.994
positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902043130.993
mesenchyme morphogenesisGO:0072132320.992
myeloid cell homeostasisGO:00022621140.991
Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090100430.991
erythrocyte differentiationGO:0030218880.991
Mouse
embryonic skeletal system developmentGO:00487061200.990
Mouse
regulation of bmp signaling pathwayGO:0030510600.989
Human Mouse
stem cell differentiationGO:00488632680.989
nodal signaling pathway involved in determination of left right asymmetryGO:003810720.989
oocyte axis specificationGO:000730920.988
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetryGO:190009420.987
cell adhesionGO:00071553290.986
Mouse
negative regulation of mitotic cell cycleGO:0045930580.985
smad protein complex assemblyGO:000718310.985
Human
regionalizationGO:00030023370.984
positive regulation of bmp signaling pathwayGO:0030513230.984
Human
axon guidanceGO:00074111410.984
regulation of peptidyl threonine phosphorylationGO:0010799120.983
Mouse
lens development in camera type eyeGO:0002088620.983
Mouse
homeostasis of number of cellsGO:00488722100.982
Mouse
axonogenesisGO:00074092740.982
molting cycleGO:0042303900.982
neuron projection guidanceGO:00974851410.981
paraxial mesoderm morphogenesisGO:0048340100.980
Mouse
transforming growth factor beta receptor signaling pathwayGO:0007179710.980
germ cell developmentGO:00072811850.979
Mouse Fly
response to bmpGO:0071772140.978
Mouse
mesendoderm developmentGO:004838230.977
regulation of smad protein import into nucleusGO:006039030.977
wound healingGO:00420601570.976
Mouse
peptidyl amino acid modificationGO:00181933360.975
Mouse
cellular response to growth factor stimulusGO:00713631970.973
pathway restricted smad protein phosphorylationGO:0060389100.971
regulation of cellular amino acid metabolic processGO:000652150.971
striated muscle tissue developmentGO:00147062930.971
Mouse
cellular amine metabolic processGO:0044106440.970
camera type eye developmentGO:00430102660.970
Mouse
negative regulation of protein phosphorylationGO:00019331260.970
Mouse
embryonic skeletal system morphogenesisGO:0048704910.969
Mouse
blood vessel morphogenesisGO:00485142850.968
Mouse
regulation of pathway restricted smad protein phosphorylationGO:006039360.967
endocardial cushion morphogenesisGO:0003203180.967
response to growth factorGO:00708481980.966
neural tube developmentGO:00219151600.965
endoderm formationGO:0001706200.964
Mouse
female gamete generationGO:0007292740.964
Fly
endoderm developmentGO:0007492450.963
regulation of peptidyl serine phosphorylationGO:0033135390.963
Mouse
response to cholesterolGO:007072340.961
embryonic organ morphogenesisGO:00485622760.960
Mouse
body morphogenesisGO:0010171450.960
Worm
filopodium assemblyGO:0046847190.960
gland developmentGO:00487323300.959
foregut morphogenesisGO:0007440120.959
Mouse
regulation of osteoblast differentiationGO:0045667670.959
Mouse
single organism cell adhesionGO:00986021560.958
Mouse
endothelium developmentGO:0003158450.957
regulation of cell cycleGO:00517262810.957
lymphocyte differentiationGO:00300982420.957
activin receptor signaling pathwayGO:0032924180.955
endocardial cushion formationGO:0003272130.954
artery developmentGO:0060840530.949
Mouse
t cell differentiationGO:00302171740.949
peptidyl threonine modificationGO:0018210310.948
Mouse
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.946
endocardial cushion developmentGO:0003197260.945
positive regulation of cellular amino acid metabolic processGO:004576430.945
oogenesisGO:0048477560.945
Fly
lung developmentGO:00303241640.945
Mouse
mesenchyme developmentGO:00604851520.945
bmp signaling pathwayGO:0030509930.943
Human Mouse
schwann cell proliferationGO:001401020.943
respiratory system developmentGO:00605411900.942
Mouse
regulation of osteoblast proliferationGO:0033688150.941
Mouse
mammary gland morphogenesisGO:0060443540.941
negative regulation of bmp signaling pathwayGO:0030514350.941
Mouse
oocyte constructionGO:000730820.940
cardiac chamber developmentGO:00032051080.939
embryonic hemopoiesisGO:0035162230.939
dna metabolic processGO:00062593030.938
organ growthGO:00352651170.937
Mouse Worm
epidermis developmentGO:00085441870.936
epithelial tube morphogenesisGO:00605623030.936
skin developmentGO:00435882200.934
regulation of defense responseGO:00313472330.934
Mouse
regulation of cellular amine metabolic processGO:0033238200.933
positive regulation of protein modification processGO:00314012990.930
negative regulation of t cell proliferationGO:0042130380.928
regulation of stem cell differentiationGO:2000736500.926
tolerance induction to self antigenGO:000251340.922
endocardial cell differentiationGO:006095640.922
regulation of hair follicle developmentGO:005179790.920
stem cell developmentGO:00488642190.919
pole plasm assemblyGO:000731520.919
formation of anatomical boundaryGO:004885960.918
mitotic cell cycleGO:00002781950.916
inflammatory responseGO:00069542440.916
Mouse
regulation of mitotic cell cycleGO:00073461260.914
cell fate commitment involved in formation of primary germ layerGO:0060795260.911
Mouse
metanephric mesenchyme developmentGO:0072075100.910
immune response activating signal transductionGO:00027571160.910
oocyte differentiationGO:0009994350.909
protein localization to nucleusGO:00345041210.908
peptidyl threonine phosphorylationGO:0018107310.907
Mouse
myeloid cell differentiationGO:00300992330.904
Mouse
respiratory tube developmentGO:00303231670.902
Mouse
endodermal cell fate commitmentGO:0001711120.901
positive regulation of osteoblast differentiationGO:0045669340.899
Mouse
neural tube closureGO:0001843900.891
negative regulation of cell proliferationGO:00082852960.890
peptidyl serine phosphorylationGO:0018105740.888
Mouse
multicellular organism growthGO:00352641610.886
Worm
cellular response to organic cyclic compoundGO:0071407870.885
Mouse
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.881
establishment or maintenance of cytoskeleton polarityGO:003095220.881
regulation of transforming growth factor beta receptor signaling pathwayGO:0017015430.881
Human Mouse
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetryGO:190016420.881
cardiac endothelial cell differentiationGO:000334840.881
regulation of mapk cascadeGO:00434082480.879
regulation of epithelial cell proliferationGO:00506781410.878
Mouse
atrioventricular valve formationGO:000319050.878
blastoderm segmentationGO:0007350130.876
cardiac muscle cell proliferationGO:0060038310.875
Mouse
cardiac epithelial to mesenchymal transitionGO:0060317180.873
atrioventricular canal developmentGO:003630250.872
lymphocyte homeostasisGO:0002260640.872
amine metabolic processGO:0009308450.871
spermatid differentiationGO:00485151150.870
positive regulation of gene silencing by mirnaGO:200063710.870
cellular amino acid metabolic processGO:00065201030.869
mammary gland epithelium developmentGO:0061180650.863
regulation of bindingGO:00510981110.863
regulation of cell cycle phase transitionGO:1901987770.863
chemotaxisGO:00069352470.861
mesenchymal cell differentiationGO:00487621070.860
metencephalon developmentGO:0022037890.860
regulation of muscle contractionGO:0006937490.857
Mouse
gastrulation with mouth forming secondGO:0001702290.856
smad protein import into nucleusGO:000718460.856
leukocyte differentiationGO:00025213420.844
myeloid leukocyte differentiationGO:00025731190.844
regulation of cardiac muscle contractionGO:0055117210.843
Mouse
regulation of protein import into nucleusGO:0042306520.841
cardiac muscle tissue growthGO:0055017370.839
Mouse
actin cytoskeleton organizationGO:00300362200.836
single organismal cell cell adhesionGO:00163371310.835
Mouse
alpha beta t cell differentiationGO:0046632690.834
connective tissue developmentGO:00614481790.832
Mouse
regulation of chondrocyte differentiationGO:0032330330.829
Mouse
response to organic cyclic compoundGO:00140701980.820
Mouse
response to transforming growth factor betaGO:0071559880.820
mechanoreceptor differentiationGO:0042490670.815
regulation of hair cycleGO:0042634110.814
regulation of muscle system processGO:0090257800.814
Mouse
negative regulation of immune system processGO:00026832090.813
regulation of protein stabilityGO:0031647520.813
negative regulation of protein metabolic processGO:00512482820.811
Human Mouse
muscle contractionGO:00069361010.811
Mouse
skeletal system morphogenesisGO:00487052030.807
Mouse
negative regulation of osteoblast differentiationGO:0045668300.807
Mouse
mesoderm morphogenesisGO:0048332640.806
Mouse
regulation of blood circulationGO:1903522930.803
Mouse
ventricular septum developmentGO:0003281420.802
Mouse
nodal signaling pathwayGO:0038092100.802
heart valve morphogenesisGO:0003179210.802
muscle system processGO:00030121410.801
Mouse
negative regulation of cell cycle phase transitionGO:1901988480.800
sebaceous gland developmentGO:004873370.798
cardiac ventricle morphogenesisGO:0003208500.798
Mouse
embryonic heart tube morphogenesisGO:0003143510.796
Mouse
palate developmentGO:0060021760.793
liver developmentGO:0001889660.790
Mouse
heart valve formationGO:0003188100.789
placenta developmentGO:00018901400.788
hair cycleGO:0042633900.788
regulation of neuron differentiationGO:00456642810.787
regulation of t cell activationGO:00508631700.786
chondrocyte differentiationGO:0002062720.785
Mouse
positive regulation of leukocyte differentiationGO:1902107860.784
mesoderm formationGO:0001707620.783
Mouse
regulation of epithelial to mesenchymal transitionGO:0010717220.783
dendrite developmentGO:00163581150.780
positive regulation of epithelial to mesenchymal transitionGO:0010718130.775
cellular response to dna damage stimulusGO:00069742070.772
regulation of cell morphogenesis involved in differentiationGO:00107691510.771
endothelial cell differentiationGO:0045446410.771
positive regulation of intracellular protein transportGO:0090316420.768
negative regulation of response to woundingGO:1903035770.766
Mouse
muscle tissue developmentGO:00605373080.764
Mouse
positive regulation of intracellular transportGO:0032388700.754
mesenchymal cell developmentGO:0014031930.754
hindbrain developmentGO:00309021280.750
Mouse
fused antrum stageGO:004816510.748
positive regulation of nucleocytoplasmic transportGO:0046824300.748
protein localization to organelleGO:00333651850.744
ameboidal type cell migrationGO:00016671280.743
regulation of t cell differentiationGO:0045580830.743
hair follicle developmentGO:0001942850.742
oocyte anterior posterior axis specificationGO:000731420.738
embryonic epithelial tube formationGO:00018381300.734
spermatogenesisGO:00072832840.728
embryonic digit morphogenesisGO:0042733560.725
nuclear transportGO:00511691390.722
positive regulation of activin receptor signaling pathwayGO:003292730.719
mesodermal cell differentiationGO:0048333220.719
Mouse
negative regulation of epithelial cell proliferationGO:0050680640.718
cardiocyte differentiationGO:0035051870.717
regulation of organelle organizationGO:00330432890.717
nephron tubule morphogenesisGO:0072078680.711
cell fate determinationGO:0001709320.709
negative regulation of defense responseGO:0031348770.707
Mouse
regulation of epidermis developmentGO:0045682330.702
cellular response to transforming growth factor beta stimulusGO:0071560880.701
negative regulation of cellular amine metabolic processGO:003323910.701
positive regulation of meiotic cell cycleGO:0051446150.700
regulation of endothelial cell differentiationGO:0045601100.698
regulation of blood vessel sizeGO:0050880560.695
regulation of muscle tissue developmentGO:1901861970.692
Mouse
regulation of alpha beta t cell differentiationGO:0046637350.689
blood circulationGO:00080151950.689
Mouse
somite developmentGO:0061053810.689
embryonic limb morphogenesisGO:00303261260.687
formation of primary germ layerGO:0001704770.683
Mouse
regulation of cellular component biogenesisGO:00440871810.682
Fly
regulation of cellular response to growth factor stimulusGO:0090287820.681
Human Mouse
regulation of organ morphogenesisGO:20000271440.679
cardiac muscle tissue developmentGO:00487381300.676
Mouse
positive regulation of immature t cell proliferationGO:003309140.676
cartilage developmentGO:00512161400.673
Mouse
antral ovarian follicle growthGO:000154750.670
cellular response to lipidGO:00713961450.666
transdifferentiationGO:006029010.666
negative regulation of protein modification processGO:00314001630.664
Mouse
regulation of histone acetylationGO:0035065190.663
cardiac chamber morphogenesisGO:0003206930.660
Mouse
inner ear receptor cell differentiationGO:0060113610.658
lymphocyte proliferationGO:00466511640.658
retinal ganglion cell axon guidanceGO:0031290180.657
Fly
cognitionGO:00508901490.653
leukocyte proliferationGO:00706611720.650
mapk cascadeGO:00001652810.650
Mouse
t cell differentiation in thymusGO:0033077770.650
gene silencing by mirnaGO:0035195100.648
somite rostral caudal axis specificationGO:0032525130.647
striated muscle cell proliferationGO:0014855390.647
Mouse
ventricular cardiac muscle tissue developmentGO:0003229380.644
Mouse
epithelial cell proliferationGO:00506731740.642
Mouse
protein targetingGO:00066051430.640
positive regulation of protein import into nucleusGO:0042307260.640
odontogenesis of dentin containing toothGO:0042475660.638
stem cell maintenanceGO:00198271300.637
Fly
positive regulation of pathway restricted smad protein phosphorylationGO:001086250.637
mesenchymal cell proliferationGO:0010463440.634
cellular macromolecule catabolic processGO:00442652060.633
odontogenesisGO:0042476780.631
heart morphogenesisGO:00030071780.629
cell migration involved in gastrulationGO:0042074130.625
positive regulation of cytoplasmic transportGO:1903651400.625
cell agingGO:0007569350.624
columnar cuboidal epithelial cell differentiationGO:0002065820.623
Fly
endodermal cell fate specificationGO:000171440.621
tolerance inductionGO:0002507140.619
epithelial to mesenchymal transitionGO:0001837470.619
endocrine system developmentGO:0035270980.616
Mouse
activation of immune responseGO:00022531380.611
positive regulation of neuron differentiationGO:00456661410.610
trunk segmentationGO:003529040.609
appendage developmentGO:00487361660.608
Fly
immune response regulating signaling pathwayGO:00027641250.607
bronchus developmentGO:0060433100.605
regulation of ossificationGO:00302781120.598
Mouse
lateral mesodermal cell differentiationGO:004837130.596
positive regulation of cell developmentGO:00107202370.595
angiogenesisGO:00015252010.589
hepaticobiliary system developmentGO:0061008670.589
Mouse
positive regulation of cellular amine metabolic processGO:003324050.588
muscle cell developmentGO:00550011330.588
bone developmentGO:00603481200.585
Mouse
paraxial mesoderm developmentGO:0048339180.585
Mouse
determination of left right symmetryGO:0007368800.585
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.584
heart field specificationGO:000312860.583
engulfment of apoptotic cellGO:004365230.581
regulation of protein targetingGO:1903533610.578
urogenital system developmentGO:00016552610.578
negative regulation of intracellular signal transductionGO:19025321670.576
chondrocyte developmentGO:0002063240.574
maternal process involved in female pregnancyGO:0060135320.573
cell fate commitmentGO:00451652100.572
neural crest cell differentiationGO:0014033540.570
gonad developmentGO:00084061410.570
positive regulation of apoptotic signaling pathwayGO:2001235950.568
regulation of cytokine productionGO:00018172660.567
Human
response to monosaccharideGO:0034284670.567
Mouse
male gamete generationGO:00482322850.565
cellular ketone metabolic processGO:0042180840.561
leukocyte homeostasisGO:0001776790.559
regulation of apoptotic signaling pathwayGO:20012331970.558
negative regulation of phosphorylationGO:00423261660.556
Mouse
cardiac muscle tissue morphogenesisGO:0055008440.555
Mouse
embryonic axis specificationGO:0000578300.554
positive regulation of cytokine productionGO:00018191740.550
developmental maturationGO:00217001930.548
blastocyst developmentGO:0001824800.546
oocyte developmentGO:0048599330.545
common partner smad protein phosphorylationGO:000718220.544
regulation of mitotic cell cycle phase transitionGO:1901990730.544
negative regulation of organ growthGO:0046621170.542
kidney developmentGO:00018222130.537
intracellular receptor signaling pathwayGO:0030522740.523
embryonic placenta developmentGO:0001892980.523
maternal placenta developmentGO:0001893200.521
cytoplasmic transportGO:00164822340.519
regulation of tolerance inductionGO:0002643100.519
regulation of intracellular transportGO:00323861590.516
positive regulation of protein localization to nucleusGO:1900182300.516
positive regulation of alpha beta t cell differentiationGO:0046638280.513
endocytosisGO:00068971680.511
regulation of cell migrationGO:00303342190.511
regulation of cell divisionGO:0051302760.510
positive regulation of cellular component biogenesisGO:0044089940.508
Fly
regulation of t cell proliferationGO:0042129920.505
maintenance of location in cellGO:0051651240.504
protein catabolic processGO:00301632210.497
Human Worm
regulation of cardiac cell fate specificationGO:200004310.497
positive regulation of t cell differentiationGO:0045582520.495
canonical wnt signaling pathway involved in positive regulation of apoptotic processGO:004433730.495
positive regulation of cell migrationGO:00303351090.495
nephron tubule developmentGO:0072080840.494
cellular protein complex assemblyGO:00436231160.491
Human
regulation of innate immune responseGO:0045088910.490
smooth muscle tissue developmentGO:0048745220.488
cell fate specificationGO:0001708720.488
actin filament organizationGO:00070151130.480
signal transduction by p53 class mediatorGO:0072331510.478
determination of heart left right asymmetryGO:0061371480.477
Mouse
amide transportGO:00428861380.477
Mouse
positive regulation of t cell activationGO:00508701010.475
embryonic heart tube developmentGO:0035050650.474
Mouse
regulation of response to woundingGO:19030341890.472
Mouse
regulation of cellular ketone metabolic processGO:0010565660.469
regulation of anti mullerian hormone signaling pathwayGO:190261210.468
covalent chromatin modificationGO:00165691630.467
positive regulation of nervous system developmentGO:00519622210.467
Fly
regulation of body fluid levelsGO:00508781620.466
canonical wnt signaling pathway involved in heart developmentGO:006131630.462
negative regulation of cellular amino acid metabolic processGO:004576300.460
skeletal system developmentGO:00015013560.459
Mouse
coagulationGO:0050817780.457
negative regulation of mitotic cell cycle phase transitionGO:1901991450.451
regulation of cell cycle processGO:00105641600.450
positive regulation of cell morphogenesis involved in differentiationGO:0010770720.450
primary neural tube formationGO:0014020950.449
peptide hormone secretionGO:00300721090.449
Mouse
gonad morphogenesisGO:003526210.449
nucleocytoplasmic transportGO:00069131390.447
mesonephric tubule morphogenesisGO:0072171630.447
regulation of heart contractionGO:0008016770.444
Mouse
positive regulation of tolerance inductionGO:000264580.441
negative regulation of cellular protein metabolic processGO:00322692470.440
Mouse
regulation of cytoskeleton organizationGO:00514931220.438
regulation of cell proliferation involved in heart morphogenesisGO:2000136150.435
stem cell fate specificationGO:004886630.435
rig i signaling pathwayGO:003952940.435
branching morphogenesis of an epithelial tubeGO:00487541590.433
protein autophosphorylationGO:0046777610.433
extrinsic apoptotic signaling pathwayGO:00971911260.432
posttranscriptional gene silencingGO:0016441100.432
heart contractionGO:0060047930.431
Mouse
positive regulation of mesoderm developmentGO:200038220.431
nuclear importGO:0051170950.427
positive regulation of b cell tolerance inductionGO:000266320.420
cardiac ventricle developmentGO:0003231830.419
Mouse
defense response to other organismGO:00985421970.417
regulation of leukocyte differentiationGO:19021051590.417
mesoderm developmentGO:00074981000.416
neuron migrationGO:00017641220.415
limb morphogenesisGO:00351081490.414
positive regulation of reproductive processGO:2000243190.414
cytoplasmic pattern recognition receptor signaling pathway in response to virusGO:003952840.412
positive regulation of ras protein signal transductionGO:0046579130.411
maternal determination of anterior posterior axis embryoGO:000835820.409
regulation of intracellular protein transportGO:0033157820.408
endocardium developmentGO:0003157100.408
regulation of protein bindingGO:0043393600.408
muscle tissue morphogenesisGO:0060415530.408
Mouse
negative regulation of endothelial cell differentiationGO:004560220.407
intracellular protein transportGO:00068862040.406
positive regulation of ossificationGO:0045778470.405
Mouse
regulation of wound healingGO:0061041400.405
Mouse
segmentationGO:0035282930.403
trachea formationGO:006044030.402
cytokine productionGO:00018163190.402
Human
central nervous system neuron differentiationGO:00219531620.399
muscle cell proliferationGO:0033002520.398
Mouse
macromolecule catabolic processGO:00090572810.396
Human Worm
carbon catabolite activation of transcriptionGO:004599140.394
smad protein signal transductionGO:0060395210.393
Human Mouse
negative regulation of wound healingGO:0061045140.390
Mouse
regulation of cardiac muscle cell proliferationGO:0060043230.389
cardiac septum morphogenesisGO:0060411460.388
Mouse
meiotic cell cycleGO:00513211220.386
nuclear divisionGO:00002801580.386
regulation of lymphocyte proliferationGO:00506701170.385
positive regulation of rac protein signal transductionGO:003502210.385
cardiac septum developmentGO:0003279590.385
regulation of cell activationGO:00508652890.384
meiotic chromosome segregationGO:0045132190.383
hemostasisGO:0007599780.383
nitrogen compound transportGO:00717052710.382
Mouse
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.381
morphogenesis of a branching structureGO:00017632030.381
response to nutrient levelsGO:00316671090.380
retina vasculature development in camera type eyeGO:0061298170.380
cell matrix adhesionGO:0007160680.378
regulation of t cell tolerance inductionGO:000266460.375
mitotic cell cycle processGO:19030471590.375
embryonic appendage morphogenesisGO:00351131260.374
bronchus morphogenesisGO:006043420.373
positive regulation of mitotic sister chromatid separationGO:190197020.373
regulation of heart morphogenesisGO:2000826220.373
neural plate mediolateral regionalizationGO:002199810.373
cellular response to abiotic stimulusGO:0071214560.371
regulation of establishment of protein localizationGO:00702011810.370
positive regulation of growthGO:00459271040.369
Worm Fly
nephron developmentGO:00720061090.368
positive regulation of protein phosphorylationGO:00019342420.368
outflow tract morphogenesisGO:0003151530.367
protein import into nucleusGO:0006606950.367
positive regulation of endothelial cell differentiationGO:004560370.366
negative regulation of phosphate metabolic processGO:00459361840.364
Mouse
cellular senescenceGO:0090398110.364
regulation of meiotic cell cycleGO:0051445340.362
organelle fissionGO:00482851700.358
regulation of reproductive processGO:2000241660.358
proteoglycan biosynthetic processGO:0030166200.356
regulation of cardiac muscle tissue developmentGO:0055024310.356
b cell homeostasisGO:0001782340.353
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.352
Mouse
immune response activating cell surface receptor signaling pathwayGO:0002429720.352
negative regulation of cell cycle processGO:0010948690.350
intermediate filament based processGO:0045103270.343
bone morphogenesisGO:0060349780.343
heart valve developmentGO:0003170230.342
regulation of system processGO:00440572000.339
Mouse
regulation of b cell tolerance inductionGO:000266120.338
positive regulation of cell deathGO:00109422240.338
renal system developmentGO:00720012250.333
meiotic cell cycle processGO:1903046770.332
regulation of cell agingGO:009034290.328
i kappab kinase nf kappab signalingGO:0007249850.328
positive regulation of chemotaxisGO:0050921380.328
regulation of cell motilityGO:20001452360.327
regulation of transferase activityGO:00513382630.327
regulation of protein transportGO:00512231630.327

Smad4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.993
Human
cancerDOID:16200.888
Human
organ system cancerDOID:005068600.888
Human
gastrointestinal system cancerDOID:311900.501
intestinal cancerDOID:1015500.501
large intestine cancerDOID:567200.452
colon cancerDOID:21900.452
colorectal cancerDOID:925600.452