IMP: Integrative Multi-species Prediction

Mus musculus

175 known processes

Smad5

MAD homolog 5 (Drosophila)

(Aliases: MusMLP,AI451355,Madh5,Dwf-C,1110051M15Rik)

Ensembl: ENSMUSG00000021540
Entrez: 17129
UniProtKB: P97454

Process Predictions
Disease Predictions

Smad5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
skeletal system development	GO:0001501	356	0.898
bone development	GO:0060348	120	0.897
stem cell development	GO:0048864	219	0.813	Mouse Fly
regionalization	GO:0003002	337	0.669	Zebrafish Mouse Fly
skeletal system morphogenesis	GO:0048705	203	0.637	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.568	Zebrafish Mouse Fly
neural tube development	GO:0021915	160	0.557
positive regulation of nervous system development	GO:0051962	221	0.557	Fly
embryonic epithelial tube formation	GO:0001838	130	0.506
regulation of cellular ketone metabolic process	GO:0010565	66	0.482
embryonic organ morphogenesis	GO:0048562	276	0.460	Zebrafish Mouse
t cell activation	GO:0042110	289	0.459	Mouse
endocrine system development	GO:0035270	98	0.458	Mouse
epithelial tube formation	GO:0072175	130	0.449
myeloid cell differentiation	GO:0030099	233	0.440
cell fate commitment	GO:0045165	210	0.434
digestive system development	GO:0055123	200	0.420	Zebrafish Mouse Fly
mesenchyme development	GO:0060485	152	0.417	Mouse
peptidyl lysine modification	GO:0018205	77	0.410
negative regulation of protein metabolic process	GO:0051248	282	0.409	Mouse
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.398	Fly
leukocyte differentiation	GO:0002521	342	0.393
blood circulation	GO:0008015	195	0.387
multicellular organism growth	GO:0035264	161	0.381	Worm
negative regulation of necroptotic process	GO:0060546	9	0.353
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.347
negative regulation of phosphorus metabolic process	GO:0010563	184	0.334	Mouse
trunk segmentation	GO:0035290	4	0.329	Fly
mesoderm development	GO:0007498	100	0.326	Mouse
neural tube formation	GO:0001841	108	0.326
stem cell differentiation	GO:0048863	268	0.325	Mouse Fly
embryonic skeletal system development	GO:0048706	120	0.322	Mouse
peptidyl amino acid modification	GO:0018193	336	0.311	Mouse
protein localization to organelle	GO:0033365	185	0.311	Mouse
morphogenesis of embryonic epithelium	GO:0016331	159	0.310
regulation of protein kinase activity	GO:0045859	232	0.306
regulation of cellular amino acid metabolic process	GO:0006521	5	0.303
neural crest cell differentiation	GO:0014033	54	0.301	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.296
lymphocyte differentiation	GO:0030098	242	0.294
mitotic cell cycle process	GO:1903047	159	0.293	Fly
regulation of neuron differentiation	GO:0045664	281	0.292
cardiac ventricle development	GO:0003231	83	0.279	Mouse
cellular protein catabolic process	GO:0044257	155	0.278
establishment of protein localization to organelle	GO:0072594	118	0.275	Mouse
ubiquitin dependent protein catabolic process	GO:0006511	129	0.271
positive regulation of neuron differentiation	GO:0045666	141	0.261
digestive tract development	GO:0048565	190	0.254	Zebrafish Mouse Fly
somitogenesis	GO:0001756	69	0.252	Mouse
g1 s transition of mitotic cell cycle	GO:0000082	57	0.249	Fly
tube formation	GO:0035148	140	0.243
dendrite development	GO:0016358	115	0.241
t cell differentiation	GO:0030217	174	0.239
regulation of cellular catabolic process	GO:0031329	242	0.234
response to growth factor	GO:0070848	198	0.232
homeostasis of number of cells	GO:0048872	210	0.231
germ cell development	GO:0007281	185	0.224
digestive tract morphogenesis	GO:0048546	147	0.223	Zebrafish Mouse Fly
epidermis development	GO:0008544	187	0.221	Mouse
glial cell apoptotic process	GO:0034349	3	0.217
modification dependent protein catabolic process	GO:0019941	133	0.212
ossification	GO:0001503	216	0.206
cartilage development	GO:0051216	140	0.206
endocardial cushion formation	GO:0003272	13	0.204	Mouse
bmp signaling pathway	GO:0030509	93	0.204
negative regulation of ripoptosome assembly involved in necroptotic process	GO:1902443	3	0.204
peptide transport	GO:0015833	133	0.204	Mouse
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.201
cardiac chamber morphogenesis	GO:0003206	93	0.196	Mouse
camera type eye development	GO:0043010	266	0.195	Mouse
regulation of protein serine threonine kinase activity	GO:0071900	157	0.193
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.190	Mouse Fly
covalent chromatin modification	GO:0016569	163	0.190
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.189	Zebrafish Mouse
striated muscle tissue development	GO:0014706	293	0.188	Mouse
blood vessel morphogenesis	GO:0048514	285	0.188	Zebrafish Mouse
formation of primary germ layer	GO:0001704	77	0.187	Mouse Fly
segmentation	GO:0035282	93	0.187	Mouse Fly
tube closure	GO:0060606	91	0.186
negative regulation of phosphorylation	GO:0042326	166	0.186	Mouse
regulation of ossification	GO:0030278	112	0.185
connective tissue development	GO:0061448	179	0.184
ventricular septum morphogenesis	GO:0060412	27	0.184	Mouse
cell fate specification	GO:0001708	72	0.184	Fly
cytoplasmic transport	GO:0016482	234	0.180	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.176	Mouse
mitotic cell cycle	GO:0000278	195	0.175	Worm Fly
regulation of hormone levels	GO:0010817	211	0.174	Mouse
gastrulation	GO:0007369	116	0.173	Zebrafish Mouse Fly
myeloid leukocyte differentiation	GO:0002573	119	0.173
protein modification by small protein conjugation	GO:0032446	187	0.172
gonad development	GO:0008406	141	0.171
heart morphogenesis	GO:0003007	178	0.170	Zebrafish Mouse
appendage development	GO:0048736	166	0.169	Fly
primary neural tube formation	GO:0014020	95	0.168
regulation of cellular component biogenesis	GO:0044087	181	0.168	Fly
regulation of kinase activity	GO:0043549	249	0.166
leukocyte proliferation	GO:0070661	172	0.165
negative regulation of necrotic cell death	GO:0060547	11	0.164
cardiac ventricle morphogenesis	GO:0003208	50	0.164	Mouse
positive regulation of cell development	GO:0010720	237	0.164	Mouse
mesenchymal cell development	GO:0014031	93	0.163	Mouse
cardiac chamber development	GO:0003205	108	0.163	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.162
negative regulation of protein phosphorylation	GO:0001933	126	0.161	Mouse
regulation of protein import into nucleus	GO:0042306	52	0.160	Mouse
stress activated protein kinase signaling cascade	GO:0031098	81	0.158
regulation of transferase activity	GO:0051338	263	0.155
axon guidance	GO:0007411	141	0.153	Mouse
amide transport	GO:0042886	138	0.153	Mouse
regulation of lymphocyte activation	GO:0051249	240	0.152
regulation of stem cell proliferation	GO:0072091	78	0.151
positive regulation of cellular amine metabolic process	GO:0033240	5	0.150
stress activated mapk cascade	GO:0051403	80	0.148
eye photoreceptor cell differentiation	GO:0001754	41	0.148
germline cell cycle switching mitotic to meiotic cell cycle	GO:0051729	1	0.147	Worm
cardiac epithelial to mesenchymal transition	GO:0060317	18	0.146	Mouse
embryonic appendage morphogenesis	GO:0035113	126	0.145
regulation of stress activated mapk cascade	GO:0032872	69	0.145
morphogenesis of a branching epithelium	GO:0061138	193	0.144	Mouse
pallium development	GO:0021543	120	0.144
regulation of cellular response to stress	GO:0080135	159	0.141
muscle cell differentiation	GO:0042692	261	0.140
purine containing compound catabolic process	GO:0072523	213	0.139
positive regulation of protein modification process	GO:0031401	299	0.139	Mouse
gland development	GO:0048732	330	0.139	Mouse
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.136
palate development	GO:0060021	76	0.136	Zebrafish Mouse
cellular amine metabolic process	GO:0044106	44	0.136
regulation of cell size	GO:0008361	72	0.135
stem cell proliferation	GO:0072089	117	0.135
single organism nuclear import	GO:1902593	95	0.134	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.132
axonogenesis	GO:0007409	274	0.132	Mouse
mesenchymal cell differentiation	GO:0048762	107	0.132	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.131	Mouse
insulin secretion	GO:0030073	89	0.127	Mouse
regulation of cell cycle	GO:0051726	281	0.127	Worm Fly
negative regulation of cell proliferation	GO:0008285	296	0.125	Mouse
heterocycle catabolic process	GO:0046700	280	0.124
regulation of protein transport	GO:0051223	163	0.124	Mouse
chromatin modification	GO:0016568	187	0.124
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.124	Mouse
developmental maturation	GO:0021700	193	0.123
negative regulation of phosphate metabolic process	GO:0045936	184	0.122	Mouse
regulation of myeloid cell differentiation	GO:0045637	96	0.122
lens development in camera type eye	GO:0002088	62	0.122	Mouse
positive regulation of growth	GO:0045927	104	0.121	Worm Fly
response to organonitrogen compound	GO:0010243	246	0.121
regulation of blood circulation	GO:1903522	93	0.120	Mouse
positive regulation of protein kinase activity	GO:0045860	144	0.120
embryonic placenta development	GO:0001892	98	0.119
ribonucleotide catabolic process	GO:0009261	208	0.118
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.116
protein catabolic process	GO:0030163	221	0.115
production of molecular mediator of immune response	GO:0002440	103	0.115
intrinsic apoptotic signaling pathway	GO:0097193	132	0.114
cellular ketone metabolic process	GO:0042180	84	0.112
apoptotic signaling pathway	GO:0097190	306	0.112
artery development	GO:0060840	53	0.111	Mouse
b cell activation	GO:0042113	161	0.111
regulation of jnk cascade	GO:0046328	62	0.111
purine nucleotide catabolic process	GO:0006195	211	0.109
striated muscle contraction	GO:0006941	45	0.109
regulation of neuron projection development	GO:0010975	169	0.109
histone methylation	GO:0016571	71	0.108
muscle cell development	GO:0055001	133	0.108
nuclear import	GO:0051170	95	0.107	Mouse
regulation of secretion by cell	GO:1903530	249	0.106
male gamete generation	GO:0048232	285	0.106
engulfment of apoptotic cell	GO:0043652	3	0.105
oocyte axis specification	GO:0007309	2	0.104
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.103
negative regulation of bmp signaling pathway	GO:0030514	35	0.102	Mouse
regulation of hormone secretion	GO:0046883	88	0.102
adaptive immune response	GO:0002250	155	0.101
protein import	GO:0017038	101	0.101	Mouse
modification dependent macromolecule catabolic process	GO:0043632	133	0.101
cellular response to dna damage stimulus	GO:0006974	207	0.099
aromatic compound catabolic process	GO:0019439	286	0.098
ventricular septum development	GO:0003281	42	0.098	Mouse
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.097	Fly
heart contraction	GO:0060047	93	0.096
cellular response to organonitrogen compound	GO:0071417	145	0.095
respiratory system development	GO:0060541	190	0.095	Mouse
regulation of cell activation	GO:0050865	289	0.094
regulation of system process	GO:0044057	200	0.094	Mouse
regulation of embryonic development	GO:0045995	71	0.093	Zebrafish
regulation of leukocyte proliferation	GO:0070663	121	0.093
mapk cascade	GO:0000165	281	0.092	Mouse
regulation of epithelial cell proliferation	GO:0050678	141	0.092	Mouse
placenta development	GO:0001890	140	0.092
intracellular protein transport	GO:0006886	204	0.090	Mouse
ribose phosphate metabolic process	GO:0019693	291	0.090
organonitrogen compound catabolic process	GO:1901565	264	0.089
metencephalon development	GO:0022037	89	0.089
rhythmic process	GO:0048511	174	0.088
histone lysine methylation	GO:0034968	50	0.088
regulation of leukocyte differentiation	GO:1902105	159	0.088
negative regulation of cell development	GO:0010721	169	0.087
negative regulation of cell fate specification	GO:0009996	4	0.087
purine ribonucleoside metabolic process	GO:0046128	241	0.087
angiogenesis	GO:0001525	201	0.087
glycosyl compound catabolic process	GO:1901658	206	0.086
protein ubiquitination	GO:0016567	171	0.086
nucleoside phosphate metabolic process	GO:0006753	338	0.086
spermatogenesis	GO:0007283	284	0.085
jnk cascade	GO:0007254	72	0.083
synapse organization	GO:0050808	125	0.083	Fly
regulation of b cell activation	GO:0050864	81	0.083
lymphocyte proliferation	GO:0046651	164	0.083
somatic stem cell maintenance	GO:0035019	47	0.082	Fly
regulation of membrane potential	GO:0042391	192	0.081
cerebellum development	GO:0021549	77	0.081
cell maturation	GO:0048469	127	0.080
cerebellum vasculature morphogenesis	GO:0061301	1	0.080
response to sterol	GO:0036314	4	0.079
appendage morphogenesis	GO:0035107	149	0.079	Fly
regulation of muscle system process	GO:0090257	80	0.079	Mouse
hindbrain development	GO:0030902	128	0.079	Mouse
peptide secretion	GO:0002790	114	0.078	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.078
development of primary sexual characteristics	GO:0045137	143	0.077
amine metabolic process	GO:0009308	45	0.077
cellular response to peptide	GO:1901653	92	0.077
heart process	GO:0003015	94	0.077
neural crest cell development	GO:0014032	48	0.077
negative regulation of lymphocyte activation	GO:0051250	91	0.077
cellular macromolecule catabolic process	GO:0044265	206	0.077
skin development	GO:0043588	220	0.076	Mouse
anatomical structure homeostasis	GO:0060249	145	0.075
cell division	GO:0051301	120	0.075	Fly
nucleotide catabolic process	GO:0009166	217	0.075
neural tube closure	GO:0001843	90	0.075
positive regulation of jun kinase activity	GO:0043507	30	0.075
glycosyl compound metabolic process	GO:1901657	246	0.074
positive regulation of lymphocyte activation	GO:0051251	140	0.073
purine ribonucleoside catabolic process	GO:0046130	205	0.073
myeloid cell homeostasis	GO:0002262	114	0.073
branching morphogenesis of an epithelial tube	GO:0048754	159	0.072	Mouse
gtp catabolic process	GO:0006184	143	0.072
regulation of tight junction assembly	GO:2000810	2	0.072
endochondral bone morphogenesis	GO:0060350	50	0.072
biomineral tissue development	GO:0031214	64	0.072
organ growth	GO:0035265	117	0.071	Mouse
hormone secretion	GO:0046879	128	0.071	Mouse
regulation of b cell tolerance induction	GO:0002661	2	0.071
oogenesis	GO:0048477	56	0.071	Fly
synapse assembly	GO:0007416	56	0.071	Fly
purine containing compound metabolic process	GO:0072521	311	0.071
chondrocyte differentiation	GO:0002062	72	0.070	Mouse
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.070
pole plasm assembly	GO:0007315	2	0.070
positive regulation of cell proliferation involved in heart valve morphogenesis	GO:0003251	1	0.069	Mouse
regulation of protein maturation	GO:1903317	96	0.069
cellular nitrogen compound catabolic process	GO:0044270	280	0.069
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.068
positive regulation of apoptotic process	GO:0043065	217	0.068
muscle tissue development	GO:0060537	308	0.068	Mouse
regulation of proteolysis	GO:0030162	164	0.068
endodermal cell fate specification	GO:0001714	4	0.068	Fly
progesterone secretion	GO:0042701	1	0.068
negative regulation of cellular component organization	GO:0051129	194	0.067
epithelial cell development	GO:0002064	159	0.067	Fly
embryonic digit morphogenesis	GO:0042733	56	0.067
endoderm development	GO:0007492	45	0.067	Mouse Fly
embryonic skeletal system morphogenesis	GO:0048704	91	0.067	Mouse
canonical wnt signaling pathway	GO:0060070	130	0.067
renal system development	GO:0072001	225	0.066
urogenital system development	GO:0001655	261	0.066
regulation of secretion	GO:0051046	274	0.066
sensory organ morphogenesis	GO:0090596	242	0.066	Zebrafish Fly
muscle system process	GO:0003012	141	0.066
regulation of lymphocyte proliferation	GO:0050670	117	0.066
protein targeting	GO:0006605	143	0.065	Mouse
regulation of cytoplasmic transport	GO:1903649	112	0.065	Mouse
regulation of cardiac muscle contraction	GO:0055117	21	0.064	Mouse
forebrain development	GO:0030900	302	0.064
protein acylation	GO:0043543	64	0.064
positive regulation of stress activated mapk cascade	GO:0032874	48	0.064
purine ribonucleotide catabolic process	GO:0009154	208	0.063
positive regulation of jnk cascade	GO:0046330	46	0.063
negative regulation of protein modification process	GO:0031400	163	0.063	Mouse
cardiac muscle tissue morphogenesis	GO:0055008	44	0.062	Mouse
b cell differentiation	GO:0030183	78	0.062
negative regulation of cell cycle process	GO:0010948	69	0.062	Fly
cochlea morphogenesis	GO:0090103	22	0.062
peptide hormone secretion	GO:0030072	109	0.062	Mouse
response to peptide	GO:1901652	136	0.062
cardiac septum morphogenesis	GO:0060411	46	0.062	Mouse
nucleoside triphosphate metabolic process	GO:0009141	230	0.061
negative regulation of cellular amine metabolic process	GO:0033239	1	0.061
muscle contraction	GO:0006936	101	0.060
maintenance of location	GO:0051235	89	0.060
protein maturation	GO:0051604	176	0.059
organic cyclic compound catabolic process	GO:1901361	295	0.059
determination of left right symmetry	GO:0007368	80	0.059	Zebrafish Mouse
wnt signaling pathway	GO:0016055	188	0.059
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.059
developmental growth involved in morphogenesis	GO:0060560	138	0.059
bone morphogenesis	GO:0060349	78	0.058
morphogenesis of a branching structure	GO:0001763	203	0.058	Mouse
purine ribonucleotide metabolic process	GO:0009150	290	0.058
nucleoside phosphate catabolic process	GO:1901292	222	0.057
regulation of nucleocytoplasmic transport	GO:0046822	73	0.057	Mouse
positive regulation of cellular component biogenesis	GO:0044089	94	0.057	Fly
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.057
nucleobase containing small molecule metabolic process	GO:0055086	352	0.057
protein modification by small protein conjugation or removal	GO:0070647	207	0.057
purine nucleotide metabolic process	GO:0006163	302	0.057
mesoderm formation	GO:0001707	62	0.056	Mouse
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.056
endothelial cell activation	GO:0042118	1	0.056	Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.055
somite development	GO:0061053	81	0.055	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.055	Mouse
regulation of peptide hormone secretion	GO:0090276	75	0.055
paraxial mesoderm morphogenesis	GO:0048340	10	0.054	Mouse
regulation of organelle organization	GO:0033043	289	0.054
b cell proliferation	GO:0042100	53	0.054
neural crest cell migration	GO:0001755	32	0.053
negative regulation of intracellular signal transduction	GO:1902532	167	0.053
positive regulation of programmed cell death	GO:0043068	218	0.053
purine nucleoside metabolic process	GO:0042278	241	0.053
nucleoside metabolic process	GO:0009116	246	0.053
locomotory behavior	GO:0007626	195	0.053
response to acid chemical	GO:0001101	111	0.053
fat cell differentiation	GO:0045444	160	0.053
response to insulin	GO:0032868	100	0.053
peptidyl tyrosine phosphorylation	GO:0018108	143	0.053
positive regulation of map kinase activity	GO:0043406	84	0.052
microtubule based process	GO:0007017	236	0.052
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.052
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.052
intracellular mrna localization	GO:0008298	4	0.052
syncytium formation by plasma membrane fusion	GO:0000768	42	0.052
protein methylation	GO:0006479	81	0.052
hepaticobiliary system development	GO:0061008	67	0.051	Mouse
regulation of mapk cascade	GO:0043408	248	0.051
negative regulation of leukocyte proliferation	GO:0070664	46	0.051
chromatin organization	GO:0006325	206	0.051
organophosphate catabolic process	GO:0046434	232	0.050
retina development in camera type eye	GO:0060041	119	0.050
wound healing	GO:0042060	157	0.050	Mouse
positive regulation of osteoblast differentiation	GO:0045669	34	0.050
stem cell maintenance	GO:0019827	130	0.050	Fly
branchiomotor neuron axon guidance	GO:0021785	7	0.050
response to oxygen levels	GO:0070482	62	0.050
negative regulation of nervous system development	GO:0051961	156	0.049
immunoglobulin mediated immune response	GO:0016064	69	0.049
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.049
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.049	Mouse
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.049
negative regulation of cell cycle	GO:0045786	123	0.049	Worm Fly
response to molecule of bacterial origin	GO:0002237	143	0.048
antibacterial peptide biosynthetic process	GO:0002780	2	0.048
embryonic axis specification	GO:0000578	30	0.048	Mouse
positive regulation of cell death	GO:0010942	224	0.048
nitrogen compound transport	GO:0071705	271	0.048	Mouse
regulation of muscle tissue development	GO:1901861	97	0.048	Mouse
response to transforming growth factor beta	GO:0071559	88	0.048
telencephalon development	GO:0021537	186	0.048
regulation of lymphocyte differentiation	GO:0045619	107	0.048
response to uv	GO:0009411	44	0.047
labyrinthine layer development	GO:0060711	49	0.047
mesodermal cell differentiation	GO:0048333	22	0.047	Mouse
labyrinthine layer blood vessel development	GO:0060716	21	0.047
regulation of homeostatic process	GO:0032844	182	0.047
regulation of striated muscle cell differentiation	GO:0051153	81	0.046
respiratory tube development	GO:0030323	167	0.046	Mouse
epithelial cell proliferation	GO:0050673	174	0.046	Mouse
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902043	13	0.046
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.046	Mouse
cellular response to lipid	GO:0071396	145	0.045
negative regulation of endothelial cell differentiation	GO:0045602	2	0.045
female gamete generation	GO:0007292	74	0.045	Fly
circulatory system process	GO:0003013	197	0.045
dna metabolic process	GO:0006259	303	0.045
cell cycle g1 s phase transition	GO:0044843	57	0.044	Fly
histone modification	GO:0016570	159	0.044
regulation of multi organism process	GO:0043900	111	0.044
positive regulation of kinase activity	GO:0033674	155	0.044
lateral mesodermal cell differentiation	GO:0048371	3	0.044
negative regulation of lymphocyte proliferation	GO:0050672	45	0.043
cardiocyte differentiation	GO:0035051	87	0.043	Mouse
cellular component assembly involved in morphogenesis	GO:0010927	139	0.043
response to organic cyclic compound	GO:0014070	198	0.043
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.043
ribonucleotide metabolic process	GO:0009259	291	0.043
cell differentiation involved in embryonic placenta development	GO:0060706	26	0.043
limb development	GO:0060173	166	0.043
negative regulation of osteoblast proliferation	GO:0033689	4	0.042	Mouse
response to lipopolysaccharide	GO:0032496	128	0.042
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.042
negative regulation of b cell activation	GO:0050869	27	0.042
epithelial to mesenchymal transition	GO:0001837	47	0.042	Mouse
regulation of transcription from rna polymerase ii promoter in response to stress	GO:0043618	8	0.042
response to peptide hormone	GO:0043434	127	0.042
response to alcohol	GO:0097305	48	0.042
compound eye development	GO:0048749	1	0.042	Fly
kidney development	GO:0001822	213	0.042
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.042
oocyte construction	GO:0007308	2	0.042
lens fiber cell apoptotic process	GO:1990086	4	0.042
lens morphogenesis in camera type eye	GO:0002089	24	0.042
skeletal muscle cell differentiation	GO:0035914	66	0.042
regulation of protein targeting	GO:1903533	61	0.041	Mouse
cellular response to growth factor stimulus	GO:0071363	197	0.041
establishment or maintenance of cell polarity	GO:0007163	86	0.041
proteasomal protein catabolic process	GO:0010498	98	0.041
regulation of cytokine production	GO:0001817	266	0.041
regulation of bmp signaling pathway	GO:0030510	60	0.040	Zebrafish Mouse
regulation of peptidyl serine phosphorylation	GO:0033135	39	0.040	Mouse
regulation of stem cell differentiation	GO:2000736	50	0.040	Mouse
pharyngeal system development	GO:0060037	17	0.040
positive regulation of b cell activation	GO:0050871	49	0.040
pancreas development	GO:0031016	57	0.040	Mouse
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.040	Mouse
regulation of anatomical structure size	GO:0090066	178	0.040
regulation of nucleotide catabolic process	GO:0030811	122	0.040
hematopoietic progenitor cell differentiation	GO:0002244	143	0.039
protein processing	GO:0016485	163	0.039
stem cell division	GO:0017145	30	0.039	Fly
regulation of mitotic cell cycle	GO:0007346	126	0.039	Worm Fly
ribonucleoside catabolic process	GO:0042454	206	0.039
regulation of adaptive immune response	GO:0002819	90	0.039
cytokine production	GO:0001816	319	0.039
retina vasculature development in camera type eye	GO:0061298	17	0.038
paraxial mesoderm development	GO:0048339	18	0.038	Mouse
ear morphogenesis	GO:0042471	118	0.038	Zebrafish
protein localization to nucleus	GO:0034504	121	0.038	Mouse
spermatid differentiation	GO:0048515	115	0.038
negative regulation of epithelial cell proliferation	GO:0050680	64	0.038
regulation of t cell differentiation	GO:0045580	83	0.038
regulation of production of molecular mediator of immune response	GO:0002700	65	0.038
lateral mesoderm morphogenesis	GO:0048369	3	0.038
hair cycle	GO:0042633	90	0.038	Mouse
regulation of axon extension	GO:0030516	43	0.038
regulation of protein catabolic process	GO:0042176	108	0.037
regulation of necrotic cell death	GO:0010939	13	0.037
limb morphogenesis	GO:0035108	149	0.037
regulation of jun kinase activity	GO:0043506	40	0.037
cartilage development involved in endochondral bone morphogenesis	GO:0060351	24	0.037
embryonic heart tube morphogenesis	GO:0003143	51	0.037	Zebrafish Mouse
spermatid development	GO:0007286	108	0.037
regulation of intracellular transport	GO:0032386	159	0.037	Mouse
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.037	Mouse
positive regulation of smad protein import into nucleus	GO:0060391	2	0.037	Mouse
syncytiotrophoblast cell differentiation involved in labyrinthine layer development	GO:0060715	2	0.037
regulation of binding	GO:0051098	111	0.036	Mouse
syncytium formation	GO:0006949	43	0.036
striated muscle cell development	GO:0055002	125	0.035
regulation of protein localization	GO:0032880	231	0.035	Mouse
positive regulation of cell cycle	GO:0045787	92	0.035	Worm
peptidyl serine modification	GO:0018209	83	0.035	Mouse
cellular response to hormone stimulus	GO:0032870	150	0.035
liver development	GO:0001889	66	0.035	Mouse
endoderm formation	GO:0001706	20	0.035	Mouse Fly
defecation	GO:0030421	1	0.035
mesonephric tubule development	GO:0072164	94	0.035
septum primum development	GO:0003284	4	0.035
alpha beta t cell activation	GO:0046631	91	0.035
cellular homeostasis	GO:0019725	240	0.035
regulation of purine nucleotide metabolic process	GO:1900542	169	0.035
regulation of transforming growth factor beta2 production	GO:0032909	2	0.035
cation transmembrane transport	GO:0098655	266	0.035
germinal center formation	GO:0002467	16	0.035
cerebellum vasculature development	GO:0061300	1	0.035
nucleotide metabolic process	GO:0009117	332	0.035
positive regulation of stem cell proliferation	GO:2000648	59	0.034
cell cycle switching mitotic to meiotic cell cycle	GO:0051728	1	0.034	Worm
cell growth	GO:0016049	130	0.034
regulation of map kinase activity	GO:0043405	120	0.034
oocyte anterior posterior axis specification	GO:0007314	2	0.034
embryonic camera type eye development	GO:0031076	36	0.034
endodermal cell fate commitment	GO:0001711	12	0.034	Fly
positive regulation of striated muscle cell differentiation	GO:0051155	35	0.034
embryonic heart tube development	GO:0035050	65	0.033	Zebrafish Mouse
t cell differentiation in thymus	GO:0033077	77	0.033
mesoderm morphogenesis	GO:0048332	64	0.033	Mouse
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.033
methylation	GO:0032259	134	0.033
lymphocyte activation involved in immune response	GO:0002285	93	0.033
negative regulation of mitotic cell cycle	GO:0045930	58	0.033	Worm Fly
female gonad development	GO:0008585	71	0.033
peptidyl threonine phosphorylation	GO:0018107	31	0.033	Mouse
regulation of cell fate commitment	GO:0010453	19	0.033
negative regulation of hormone metabolic process	GO:0032351	4	0.033
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.033
heterochromatin organization	GO:0070828	4	0.033
nucleoside catabolic process	GO:0009164	206	0.033
lipid localization	GO:0010876	126	0.033
tissue migration	GO:0090130	68	0.033
negative regulation of insulin receptor signaling pathway	GO:0046627	14	0.032

Smad5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of cellular proliferation	DOID:14566	0	0.045
	cancer	DOID:162	0	0.033

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