Mus musculus

42 known processes

Smc2

structural maintenance of chromosomes 2

(Aliases: 5730502P04Rik,SMC-2,AI255214,Smc2l1,Fin16,CAPE,AW545314,CAP-E)

Smc2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
meiosis iGO:0007127600.990
Yeast
meiotic cell cycle processGO:1903046770.988
meiotic cell cycleGO:00513211220.947
mitotic cell cycleGO:00002781950.820
Human Yeast Worm Fly
double strand break repairGO:0006302480.813
dna metabolic processGO:00062593030.794
synapsisGO:0007129340.765
spermatogenesisGO:00072832840.695
meiotic nuclear divisionGO:00071261150.599
dna conformation changeGO:0071103370.555
cellular response to dna damage stimulusGO:00069742070.543
chromosome organization involved in meiosisGO:0070192390.541
negative regulation of cell cycleGO:00457861230.536
Yeast
dna repairGO:00062811070.513
protein catabolic processGO:00301632210.489
dna replicationGO:0006260520.488
microtubule cytoskeleton organizationGO:00002261570.484
Fly
heterochromatin assemblyGO:003150720.472
cell cycle checkpointGO:0000075470.441
male gamete generationGO:00482322850.430
microtubule based processGO:00070172360.429
Fly
regulation of centriole replicationGO:004659910.417
organelle fissionGO:00482851700.397
microtubule organizing center organizationGO:0031023280.394
response to muscle inactivityGO:001487040.386
female meiotic divisionGO:0007143210.382
development of primary sexual characteristicsGO:00451371430.365
regulation of cell cycle processGO:00105641600.353
Yeast
regulation of cellular catabolic processGO:00313292420.347
chromosome segregationGO:0007059480.308
spindle assembly involved in meiosisGO:009030640.294
regulation of microtubule based processGO:0032886520.293
centrosome organizationGO:0051297260.286
macromolecule catabolic processGO:00090572810.279
negative regulation of cellular component organizationGO:00511291940.276
Yeast
gonad developmentGO:00084061410.258
regulation of dna replicationGO:0006275170.255
mitotic cell cycle processGO:19030471590.250
Human Yeast Worm Fly
centrosome cycleGO:0007098230.221
microtubule polymerization or depolymerizationGO:0031109260.214
regulation of cell cycle g2 m phase transitionGO:1902749100.209
dna packagingGO:0006323300.207
nuclear divisionGO:00002801580.189
reciprocal dna recombinationGO:0035825160.177
nucleic acid phosphodiester bond hydrolysisGO:0090305490.175
Yeast
regulation of organelle organizationGO:00330432890.173
Yeast
intrinsic apoptotic signaling pathwayGO:00971931320.170
centromere complex assemblyGO:003450830.164
establishment of organelle localizationGO:00516561220.164
negative regulation of cell cycle processGO:0010948690.157
Yeast
recombinational repairGO:0000725210.152
cellular nitrogen compound catabolic processGO:00442702800.151
Yeast
cellular macromolecule catabolic processGO:00442652060.146
neuron migrationGO:00017641220.145
apoptotic signaling pathwayGO:00971903060.139
dna catabolic process exonucleolyticGO:000073830.137
cellular protein catabolic processGO:00442571550.134
regulation of microtubule cytoskeleton organizationGO:0070507370.133
cellular protein complex disassemblyGO:0043624360.133
heterochromatin organizationGO:007082840.131
kinetochore organizationGO:005138320.131
negative regulation of mitotic cell cycleGO:0045930580.130
regulation of protein complex disassemblyGO:0043244280.129
regulation of mitotic cell cycle phase transitionGO:1901990730.128
centrosome separationGO:005129940.127
regulation of cell cycleGO:00517262810.127
Yeast
regulation of protein depolymerizationGO:1901879260.127
germ cell developmentGO:00072811850.125
cellular protein complex assemblyGO:00436231160.120
mitotic chromosome condensationGO:000707610.114
Human Yeast Worm Fly
negative regulation of protein depolymerizationGO:1901880210.113
regulation of chromosome organizationGO:0033044830.112
purine ribonucleotide catabolic processGO:00091542080.105
Yeast
mitotic cytokinesisGO:000028140.102
aromatic compound catabolic processGO:00194392860.100
Yeast
mitotic cell cycle checkpointGO:0007093310.099
heterocycle catabolic processGO:00467002800.099
Yeast
purine nucleotide catabolic processGO:00061952110.098
Yeast
spermatid differentiationGO:00485151150.091
regulation of transferase activityGO:00513382630.090
proteolysis involved in cellular protein catabolic processGO:00516031470.089
sister chromatid segregationGO:0000819200.088
Human Yeast Worm Fly
translesion synthesisGO:001998510.087
chromatin remodeling at centromereGO:003105520.086
negative regulation of protein complex disassemblyGO:0043242220.086
chromatin organizationGO:00063252060.082
regulation of cell cycle phase transitionGO:1901987770.082
positive regulation of cell cycle processGO:0090068610.082
regulation of mitotic cell cycleGO:00073461260.080
microtubule based movementGO:0007018840.078
purine ribonucleoside triphosphate catabolic processGO:00092071990.078
Yeast
protein import into nucleusGO:0006606950.077
regulation of cytoskeleton organizationGO:00514931220.077
regulation of microtubule depolymerizationGO:0031114130.077
genitalia developmentGO:0048806370.077
negative regulation of cell cycle phase transitionGO:1901988480.076
protein depolymerizationGO:0051261340.075
ubiquitin dependent protein catabolic processGO:00065111290.071
spindle assembly involved in female meiosis iGO:000705720.070
synaptonemal complex assemblyGO:0007130130.068
negative regulation of phagocytosisGO:005076540.068
regulation of microtubule polymerization or depolymerizationGO:0031110200.068
organelle assemblyGO:00709251770.068
carbohydrate derivative catabolic processGO:19011362310.066
Yeast
dna recombinationGO:0006310920.066
negative regulation of mitotic cell cycle phase transitionGO:1901991450.065
male meiosisGO:0007140370.064
negative regulation of microtubule depolymerizationGO:0007026130.064
nucleoside catabolic processGO:00091642060.063
Yeast
mitotic centrosome separationGO:000710040.063
protein complex disassemblyGO:0043241400.062
mitotic sister chromatid segregationGO:0000070140.061
Human Yeast Worm Fly
nucleobase containing small molecule metabolic processGO:00550863520.059
Yeast
nucleus localizationGO:0051647200.058
negative regulation of meiotic cell cycle phase transitionGO:190199430.058
response to inactivityGO:001485440.057
double strand break repair via homologous recombinationGO:0000724210.057
ribonucleoside catabolic processGO:00424542060.056
Yeast
gene silencingGO:0016458380.055
mitotic recombinationGO:000631230.054
female meiosis iGO:000714470.054
nuclear transportGO:00511691390.054
spermatid developmentGO:00072861080.053
regulation of cellular component biogenesisGO:00440871810.053
mitotic g2 dna damage checkpointGO:000709580.053
regulation of centrosome cycleGO:0046605100.053
nucleoside triphosphate metabolic processGO:00091412300.053
Yeast
organophosphate catabolic processGO:00464342320.053
Yeast
chromatin modificationGO:00165681870.053
ribonucleoside triphosphate metabolic processGO:00091992200.052
Yeast
dna ligationGO:000626630.052
spindle assembly involved in female meiosisGO:000705630.050
regulation of purine nucleotide catabolic processGO:00331211220.049
regulation of nucleoside metabolic processGO:00091181300.049
negative regulation of microtubule polymerization or depolymerizationGO:0031111150.049
meiosis iiGO:000713570.049
organelle localizationGO:00516401790.048
regulation of mitosisGO:0007088290.046
ribonucleoside triphosphate catabolic processGO:00092031990.046
Yeast
regulation of apoptotic signaling pathwayGO:20012331970.046
regulation of cellular amino acid metabolic processGO:000652150.046
spindle organizationGO:0007051280.045
Fly
protein oligomerizationGO:0051259670.045
ras protein signal transductionGO:0007265770.045
cellular ketone metabolic processGO:0042180840.045
cellular amine metabolic processGO:0044106440.044
mitotic nuclear divisionGO:0007067480.044
Human Yeast Worm Fly
nucleotide metabolic processGO:00091173320.044
Yeast
meiotic chromosome segregationGO:0045132190.043
regulation of hydrolase activityGO:00513362460.043
regulation of cellular amine metabolic processGO:0033238200.043
negative regulation of nuclear divisionGO:0051784190.043
Yeast
negative regulation of cytoskeleton organizationGO:0051494360.043
organic cyclic compound catabolic processGO:19013612950.042
Yeast
small gtpase mediated signal transductionGO:0007264970.042
female gamete generationGO:0007292740.042
positive regulation of organelle organizationGO:00106381280.041
positive regulation of hydrolase activityGO:00513451480.041
positive regulation of protein modification processGO:00314012990.040
positive regulation of protein kinase activityGO:00458601440.040
reciprocal meiotic recombinationGO:0007131160.040
ribose phosphate metabolic processGO:00196932910.039
Yeast
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434400.039
regulation of chromatin modificationGO:1903308570.039
rna dependent dna replicationGO:000627830.039
modification dependent protein catabolic processGO:00199411330.038
cellular response to organic cyclic compoundGO:0071407870.038
dendrite developmentGO:00163581150.038
glycosyl compound metabolic processGO:19016572460.037
Yeast
protein localization to nucleusGO:00345041210.037
regulation of protein localizationGO:00328802310.037
positive regulation of kinase activityGO:00336741550.037
dna biosynthetic processGO:0071897220.037
negative regulation of organelle organizationGO:0010639900.036
Yeast
regulation of purine nucleotide metabolic processGO:19005421690.036
response to organic cyclic compoundGO:00140701980.036
positive regulation of nucleocytoplasmic transportGO:0046824300.036
regulation of dna endoreduplicationGO:003287530.036
purine nucleoside triphosphate metabolic processGO:00091442260.035
Yeast
organonitrogen compound catabolic processGO:19015652640.035
Yeast
actin cytoskeleton organizationGO:00300362200.035
multi organism behaviorGO:0051705620.035
interspecies interaction between organismsGO:0044419830.035
purine nucleoside catabolic processGO:00061522050.034
Yeast
cellular response to hormone stimulusGO:00328701500.033
modification dependent macromolecule catabolic processGO:00436321330.033
ribonucleotide catabolic processGO:00092612080.033
Yeast
purine nucleoside triphosphate catabolic processGO:00091462030.033
Yeast
microtubule depolymerizationGO:0007019150.033
ribonucleoprotein complex localizationGO:007116610.033
regulation of proteasomal protein catabolic processGO:0061136460.033
cytoplasmic transportGO:00164822340.033
rna interferenceGO:001624620.033
negative regulation of dna dependent dna replicationGO:200010410.032
dna replication independent nucleosome assemblyGO:000633610.032
neural precursor cell proliferationGO:00613511210.031
negative regulation of sister chromatid segregationGO:003304670.031
negative regulation of cellular protein metabolic processGO:00322692470.031
macromolecular complex disassemblyGO:0032984430.031
single organism nuclear importGO:1902593950.031
dna unwinding involved in dna replicationGO:000626850.030
histone threonine phosphorylationGO:003540510.030
purine nucleoside metabolic processGO:00422782410.030
Yeast
endocytosisGO:00068971680.029
regulation of dna dependent dna replicationGO:009032980.029
positive regulation of cellular catabolic processGO:00313311480.029
peptidyl amino acid modificationGO:00181933360.029
nucleoside phosphate metabolic processGO:00067533380.029
Yeast
regulation of cellular response to stressGO:00801351590.028
cellular amino acid metabolic processGO:00065201030.028
dna modificationGO:0006304500.028
base excision repairGO:000628490.028
positive regulation of protein phosphorylationGO:00019342420.028
regulation of nucleotide catabolic processGO:00308111220.028
positive regulation of cytoskeleton organizationGO:0051495490.028
cell divisionGO:00513011200.027
Yeast
ribonucleoside metabolic processGO:00091192450.027
Yeast
blastocyst developmentGO:0001824800.027
response to radiationGO:00093141650.027
nucleoside phosphate catabolic processGO:19012922220.026
Yeast
regulation of kinase activityGO:00435492490.026
purine ribonucleotide metabolic processGO:00091502900.026
Yeast
dna endoreduplicationGO:004202340.026
glycosyl compound catabolic processGO:19016582060.026
Yeast
negative regulation of gene expression epigeneticGO:0045814150.026
positive regulation of chromatin modificationGO:1903310280.026
rna 3 end processingGO:0031123200.026
axonogenesisGO:00074092740.026
amine metabolic processGO:0009308450.026
positive regulation of cellular component biogenesisGO:0044089940.026
g1 s transition of mitotic cell cycleGO:0000082570.025
non recombinational repairGO:0000726100.025
receptor mediated endocytosisGO:0006898510.025
positive regulation of gtp catabolic processGO:0033126850.025
negative regulation of molecular functionGO:00440922580.024
positive regulation of cellular amine metabolic processGO:003324050.024
nucleotide catabolic processGO:00091662170.024
Yeast
positive regulation of nervous system developmentGO:00519622210.024
posttranscriptional regulation of gene expressionGO:00106081550.024
regulation of cellular ketone metabolic processGO:0010565660.024
purine ribonucleoside metabolic processGO:00461282410.024
Yeast
protein modification by small protein conjugation or removalGO:00706472070.024
regulation of cellular protein catabolic processGO:1903362610.023
deoxyribonucleotide metabolic processGO:0009262140.023
positive regulation of glycogen catabolic processGO:004581920.023
protein localization to organelleGO:00333651850.022
mrna 3 end processingGO:0031124160.022
nucleocytoplasmic transportGO:00069131390.022
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.022
attachment of spindle microtubules to kinetochoreGO:000860840.022
regulation of ras protein signal transductionGO:00465781140.022
regulation of double strand break repair via nonhomologous end joiningGO:200103220.022
maintenance of locationGO:0051235890.022
dna catabolic processGO:0006308190.022
intracellular protein transportGO:00068862040.021
regulation of muscle adaptationGO:0043502310.021
response to light stimulusGO:00094161350.021
positive regulation of gtpase activityGO:0043547850.021
mrna transportGO:0051028130.021
purine nucleotide metabolic processGO:00061633020.021
Yeast
viral processGO:0016032410.021
protein ubiquitinationGO:00165671710.021
purine ribonucleoside triphosphate metabolic processGO:00092052200.021
Yeast
protein homooligomerizationGO:0051260430.020
rho protein signal transductionGO:0007266320.020
cellular response to oxidative stressGO:0034599760.020
apoptotic cell clearanceGO:0043277170.020
regulation of circadian rhythmGO:0042752580.020
regulation of vesicle mediated transportGO:00606271390.020
protein heterotetramerizationGO:005129040.020
chromatin assemblyGO:0031497130.019
muscle cell differentiationGO:00426922610.019
cellularizationGO:000734910.019
nucleoside monophosphate metabolic processGO:0009123850.019
Yeast
negative regulation of cellular protein catabolic processGO:1903363220.019
microtubule nucleationGO:000702020.019
positive regulation of cell cycleGO:0045787920.019
ribonucleotide metabolic processGO:00092592910.019
Yeast
regulation of nucleotide metabolic processGO:00061401690.019
negative regulation of chromosome organizationGO:2001251300.019
response to steroid hormoneGO:0048545560.019
mitotic spindle organizationGO:0007052100.018
Fly
regulation of neural precursor cell proliferationGO:2000177700.018
nitrogen compound transportGO:00717052710.018
regulation of cell activationGO:00508652890.018
nucleoside triphosphate catabolic processGO:00091432050.018
Yeast
regulation of cell projection organizationGO:00313442060.018
astral microtubule organizationGO:003095330.018
nucleoside phosphate biosynthetic processGO:1901293790.018
forebrain developmentGO:00309003020.018
purine containing compound catabolic processGO:00725232130.017
Yeast
negative regulation of protein metabolic processGO:00512482820.017
dna integrity checkpointGO:0031570280.017
activation of adenylate cyclase activityGO:000719040.017
cell type specific apoptotic processGO:00972852680.017
nuclear dna replicationGO:003326030.017
purine ribonucleoside monophosphate metabolic processGO:0009167800.017
Yeast
response to inorganic substanceGO:0010035960.017
cell cycle g2 m phase transitionGO:0044839200.016
positive regulation of transferase activityGO:00513471670.016
regulation of cell divisionGO:0051302760.016
Yeast
response to oxidative stressGO:00069791230.016
chromosome separationGO:0051304140.016
negative regulation of cell activationGO:00508661110.016
double strand break repair via nonhomologous end joiningGO:0006303100.016
protein polymerizationGO:0051258570.016
regulation of chromatin organizationGO:1902275570.016
protein maturationGO:00516041760.016
meiotic cell cycle checkpointGO:003331320.016
proteasomal protein catabolic processGO:0010498980.016
dna catabolic process endonucleolyticGO:0000737150.016
cellular response to lipidGO:00713961450.016
regulation of meiosis iGO:006063170.015
Yeast
positive regulation of nucleotide metabolic processGO:00459811140.015
urogenital system developmentGO:00016552610.015
response to uvGO:0009411440.015
rna catabolic processGO:0006401290.015
dna alkylationGO:0006305430.015
regulation of attachment of spindle microtubules to kinetochoreGO:005198830.015
dna hypermethylationGO:004402630.015
multicellular organismal reproductive behaviorGO:0033057230.014
oxidation reduction processGO:00551143420.014
protein tetramerizationGO:0051262230.014
purine containing compound metabolic processGO:00725213110.014
Yeast
positive regulation of nucleotide catabolic processGO:0030813880.014
regulation of neuron projection developmentGO:00109751690.014
telencephalon developmentGO:00215371860.014
mitotic sister chromatid cohesionGO:000706410.014
negative regulation of b cell differentiationGO:004557840.014
protein polyubiquitinationGO:0000209330.014
positive regulation of purine nucleotide metabolic processGO:19005441140.014
entry into hostGO:0044409150.014
dna dependent dna replicationGO:0006261240.014
myeloid cell differentiationGO:00300992330.014
regulation of system processGO:00440572000.014
regulation of transcription by chromatin organizationGO:003440100.014
negative regulation of apoptotic cell clearanceGO:200042610.014
chromatin assembly or disassemblyGO:0006333160.014
body morphogenesisGO:0010171450.014
rna processingGO:00063961050.014
regulation of proteolysisGO:00301621640.014
nucleoside metabolic processGO:00091162460.014
Yeast
centrosome duplicationGO:0051298160.014
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.014
regulation of bindingGO:00510981110.014
embryonic placenta developmentGO:0001892980.014
cellular component assembly involved in morphogenesisGO:00109271390.013
symbiosis encompassing mutualism through parasitismGO:0044403830.013
response to decreased oxygen levelsGO:0036293590.013
germ cell proliferationGO:003609370.013
dna methylationGO:0006306430.013
positive regulation of apoptotic processGO:00430652170.013
positive regulation of nucleoside metabolic processGO:0045979910.013
positive regulation of purine nucleotide catabolic processGO:0033123880.013
positive regulation of cellular amino acid metabolic processGO:004576430.013
intra s dna damage checkpointGO:003157340.013
regulation of cytokinesisGO:003246550.013
protein importGO:00170381010.013
response to purine containing compoundGO:0014074280.013
nuclear importGO:0051170950.013
developmental cell growthGO:0048588840.013
gene silencing by rnaGO:0031047190.013
regulation of rho gtpase activityGO:0032319580.013
axon guidanceGO:00074111410.013
purine ribonucleoside catabolic processGO:00461302050.013
Yeast
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243340.013
regulation of ras gtpase activityGO:0032318880.013
cerebral cortex developmentGO:0021987860.012
negative regulation of multi organism processGO:0043901680.012
female meiosis chromosome segregationGO:001632110.012
positive regulation of cell developmentGO:00107202370.012
cdc42 protein signal transductionGO:003248800.012
regulation of intracellular transportGO:00323861590.012
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.012
organic hydroxy compound metabolic processGO:19016152030.012
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051220.012
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediatorGO:190225480.012
digestive tract morphogenesisGO:00485461470.012
compound eye developmentGO:004874910.012
multi multicellular organism processGO:00447061090.012
regulation of organelle assemblyGO:1902115190.012
positive regulation of cell divisionGO:0051781310.011
regulation of homeostatic processGO:00328441820.011
g2 dna damage checkpointGO:003157280.011
neuron deathGO:00709971540.011
neuron apoptotic processGO:00514021420.011
maintenance of dna methylationGO:001021640.011
anatomical structure homeostasisGO:00602491450.011
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.011
actomyosin structure organizationGO:0031032560.011
establishment of spindle orientationGO:0051294150.011
reproductive behaviorGO:0019098320.011
protein modification by small protein conjugationGO:00324461870.011
regulation of cytoplasmic transportGO:19036491120.011
regulation of response to dna damage stimulusGO:2001020340.011
response to denervation involved in regulation of muscle adaptationGO:001489440.011
establishment or maintenance of cell polarityGO:0007163860.011
response to oxygen levelsGO:0070482620.011
microtubule cytoskeleton organization involved in mitosisGO:190285040.011
regulation of actin filament based processGO:0032970990.011
negative regulation of proteolysisGO:0045861740.011
methylationGO:00322591340.011
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.011
cytokinetic processGO:003250620.010
regulation of protein transportGO:00512231630.010
cellular response to calcium ionGO:0071277140.010
cell fate commitmentGO:00451652100.010
positive regulation of neural precursor cell proliferationGO:2000179420.010
response to extracellular stimulusGO:00099911270.010
dna damage checkpointGO:0000077260.010
regulation of neuron differentiationGO:00456642810.010
response to hypoxiaGO:0001666580.010
male sex differentiationGO:00466611090.010
cell maturationGO:00484691270.010
spindle assembly involved in mitosisGO:009030740.010
regulation of gtp catabolic processGO:00331241130.010
response to growth factorGO:00708481980.010
locomotory behaviorGO:00076261950.010
regulation of histone modificationGO:0031056560.010
muscle tissue developmentGO:00605373080.010

Smc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
physical disorderDOID:008001500.022
organ system cancerDOID:005068600.010
breast cancerDOID:161200.010
cancerDOID:16200.010
thoracic cancerDOID:509300.010
disease of cellular proliferationDOID:1456600.010