Mus musculus

240 known processes

Stat3

signal transducer and activator of transcription 3

(Aliases: Aprf,AW109958,1110034C02Rik)

Stat3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of immune system processGO:00026832091.000
Mouse
cytokine productionGO:00018163191.000
Mouse
cytokine mediated signaling pathwayGO:00192211151.000
Human Mouse
regulation of defense responseGO:00313472331.000
Mouse
negative regulation of t cell activationGO:0050868651.000
regulation of cytokine productionGO:00018172661.000
Mouse
cellular response to peptideGO:1901653920.999
regulation of cell activationGO:00508652890.999
Mouse
negative regulation of leukocyte differentiationGO:1902106510.999
cd4 positive alpha beta t cell activationGO:0035710450.999
Mouse
regulation of leukocyte differentiationGO:19021051590.999
Mouse
production of molecular mediator of immune responseGO:00024401030.999
Mouse
type i interferon signaling pathwayGO:0060337100.999
Mouse
cd4 positive alpha beta t cell lineage commitmentGO:004337360.999
Mouse
t cell activationGO:00421102890.998
Mouse
regulation of natural killer cell differentiationGO:0032823110.998
Mouse
regulation of cellular amino acid metabolic processGO:000652150.998
peptidyl tyrosine phosphorylationGO:00181081430.998
Mouse
positive regulation of defense responseGO:00313491240.998
Mouse
tyrosine phosphorylation of stat1 proteinGO:004250830.997
immune effector processGO:00022523210.997
Mouse
t cell differentiationGO:00302171740.997
Mouse
cd4 positive alpha beta t cell differentiationGO:0043367410.997
Mouse
cellular response to cytokine stimulusGO:00713451890.997
Human Mouse
alpha beta t cell differentiation involved in immune responseGO:0002293300.997
Mouse
regulation of mast cell differentiationGO:006037530.996
Mouse
regulation of t cell differentiationGO:0045580830.996
Mouse
regulation of response to woundingGO:19030341890.996
Mouse
leukocyte differentiationGO:00025213420.996
Mouse
activation of janus kinase activityGO:004297620.995
t helper cell differentiationGO:0042093280.995
Mouse
cellular response to interferon gammaGO:0071346250.995
Mouse
adaptive immune responseGO:00022501550.995
Mouse
peptidyl tyrosine modificationGO:00182121450.994
Mouse
immune response activating signal transductionGO:00027571160.994
nucleotide binding oligomerization domain containing signaling pathwayGO:007042360.994
jak stat cascadeGO:0007259420.993
negative regulation of interferon gamma mediated signaling pathwayGO:006033610.993
myeloid cell homeostasisGO:00022621140.993
Mouse
cellular response to interleukin 4GO:0071353210.993
Mouse
cellular amino acid metabolic processGO:00065201030.993
Mouse
response to organic cyclic compoundGO:00140701980.993
Human Mouse Rat
cellular response to growth hormone stimulusGO:007137870.992
lymphocyte differentiationGO:00300982420.992
Mouse
alpha beta t cell lineage commitmentGO:000236370.992
Mouse
response to lipopolysaccharideGO:00324961280.992
Mouse
regulation of lymphocyte activationGO:00512492400.992
Mouse
response to molecule of bacterial originGO:00022371430.991
Mouse
response to interleukin 15GO:007067230.991
Mouse
interleukin 6 mediated signaling pathwayGO:007010260.991
Human
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.991
Mouse
taurine metabolic processGO:001953040.991
Mouse
positive regulation of mast cell differentiationGO:006037610.990
Mouse
regulation of insulin receptor signaling pathwayGO:0046626210.990
immune response regulating signaling pathwayGO:00027641250.990
cellular response to peptide hormone stimulusGO:0071375920.990
creatinine metabolic processGO:004644930.990
Mouse
defense response to other organismGO:00985421970.989
negative regulation of alpha beta t cell activationGO:0046636180.989
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.989
Mouse
regulation of mast cell apoptotic processGO:003302550.989
Mouse
cellular response to biotic stimulusGO:0071216920.989
Mouse
jak stat cascade involved in growth hormone signaling pathwayGO:006039740.988
regulation of alpha beta t cell differentiationGO:0046637350.988
myeloid cell differentiationGO:00300992330.987
Mouse
response to organonitrogen compoundGO:00102432460.986
negative regulation of protein metabolic processGO:00512482820.986
negative regulation of defense responseGO:0031348770.986
peptidyl amino acid modificationGO:00181933360.986
Mouse
cellular ketone metabolic processGO:0042180840.986
Mouse
t cell activation involved in immune responseGO:0002286430.986
Mouse
regulation of inflammatory responseGO:00507271470.985
Mouse
positive regulation of cellular amine metabolic processGO:003324050.985
lipopolysaccharide mediated signaling pathwayGO:0031663250.985
Mouse
regulation of cellular ketone metabolic processGO:0010565660.985
interleukin 4 mediated signaling pathwayGO:003577120.985
Mouse
t cell homeostasisGO:0043029350.985
Mouse
regulation of b cell activationGO:0050864810.984
Mouse
alpha beta t cell differentiationGO:0046632690.984
Mouse
regulation of adaptive immune responseGO:0002819900.984
Mouse
alpha beta t cell activation involved in immune responseGO:0002287310.984
Mouse
regulation of cellular amine metabolic processGO:0033238200.983
regulation of natural killer cell proliferationGO:003281720.983
Mouse
cd4 positive alpha beta t cell differentiation involved in immune responseGO:0002294280.983
Mouse
regulation of kinase activityGO:00435492490.982
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.981
Mouse
defense response to virusGO:0051607680.980
t cell differentiation involved in immune responseGO:0002292300.979
Mouse
regulation of peptidyl tyrosine phosphorylationGO:0050730930.978
regulation of chemokine secretionGO:009019640.978
cellular response to lipidGO:00713961450.977
Mouse
positive regulation of cytokine biosynthetic processGO:0042108400.977
Mouse
regulation of lymphocyte proliferationGO:00506701170.977
Mouse
dna metabolic processGO:00062593030.976
Mouse
lactationGO:0007595250.975
Mouse
regulation of t helper 1 cell differentiationGO:004562570.975
positive regulation of leukocyte differentiationGO:1902107860.974
Mouse
cellular response to organonitrogen compoundGO:00714171450.974
creatine metabolic processGO:000660040.974
Mouse
positive regulation of cytokine productionGO:00018191740.973
Mouse
regulation of cytokine biosynthetic processGO:0042035590.972
Mouse
cellular lactam metabolic processGO:007233830.971
Mouse
cellular response to amino acid stimulusGO:0071230290.970
regulation of lymphocyte differentiationGO:00456191070.969
Mouse
negative regulation of t cell differentiationGO:0045581230.968
regulation of t cell activationGO:00508631700.968
Mouse
regulation of leukocyte proliferationGO:00706631210.967
Mouse
interferon gamma mediated signaling pathwayGO:006033350.966
Mouse
negative regulation of cytokine productionGO:0001818840.965
response to interferon gammaGO:0034341340.965
Mouse
prolactin signaling pathwayGO:003816150.965
Mouse
negative regulation of cell activationGO:00508661110.963
positive regulation of natural killer cell proliferationGO:003281920.962
Mouse
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.962
alpha beta t cell activationGO:0046631910.961
Mouse
negative regulation of phosphorylationGO:00423261660.960
regulation of tyrosine phosphorylation of stat1 proteinGO:004251020.960
cellular response to molecule of bacterial originGO:0071219830.959
Mouse
response to amino acidGO:0043200370.959
regulation of jak stat cascadeGO:0046425340.959
interleukin 11 mediated signaling pathwayGO:003815420.958
positive regulation of inflammatory responseGO:0050729470.957
Mouse
regulation of syncytium formation by plasma membrane fusionGO:0060142230.956
Mouse
lymphocyte homeostasisGO:0002260640.956
Mouse
lymphocyte activation involved in immune responseGO:0002285930.954
Mouse
positive regulation of activated t cell proliferationGO:004210480.954
Mouse
cellular amine metabolic processGO:0044106440.953
positive regulation of isotype switching to ige isotypesGO:004829540.953
Mouse
positive regulation of immune effector processGO:00026991070.952
Mouse
citrate metabolic processGO:000610130.952
Mouse
response to corticosteroidGO:0031960200.951
positive regulation of protein modification processGO:00314012990.951
interleukin 18 mediated signaling pathwayGO:003565520.951
negative regulation of lymphocyte differentiationGO:0045620320.951
regulation of cd4 positive alpha beta t cell activationGO:2000514240.950
positive regulation of tyrosine phosphorylation of stat1 proteinGO:004251110.950
regulation of alpha beta t cell activationGO:0046634530.949
amine metabolic processGO:0009308450.949
negative regulation of glycolytic processGO:004582040.948
isotype switching to ige isotypesGO:004828970.946
Mouse
hepaticobiliary system developmentGO:0061008670.946
tyrosine phosphorylation of stat3 proteinGO:0042503120.944
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:009729620.942
mast cell proliferationGO:007066240.941
Mouse
negative regulation of protein phosphorylationGO:00019331260.940
t cell proliferationGO:00420981200.939
Mouse
negative regulation of intracellular signal transductionGO:19025321670.936
type 2 immune responseGO:0042092230.934
Mouse
response to alcoholGO:0097305480.934
Human Rat
negative regulation of lymphocyte activationGO:0051250910.931
response to peptide hormoneGO:00434341270.929
response to interleukin 1GO:0070555110.929
immune response regulating cell surface receptor signaling pathwayGO:0002768800.928
natural killer cell proliferationGO:000178730.927
Mouse
valine metabolic processGO:000657340.923
Mouse
skin developmentGO:00435882200.922
Zebrafish
b cell activationGO:00421131610.922
Mouse
positive regulation of cell activationGO:00508671580.922
Mouse
positive regulation of production of molecular mediator of immune responseGO:0002702450.922
Mouse
response to glucocorticoidGO:0051384200.919
embryonic placenta developmentGO:0001892980.918
positive regulation of cellular amino acid metabolic processGO:004576430.917
regulation of mapk cascadeGO:00434082480.916
cellular response to hormone stimulusGO:00328701500.914
tyrosine phosphorylation of stat proteinGO:0007260230.914
regulation of myeloid leukocyte differentiationGO:0002761580.914
Mouse
inflammatory responseGO:00069542440.912
Mouse Rat
response to interleukin 6GO:0070741100.911
Human
somatic recombination of immunoglobulin gene segmentsGO:0016447420.909
Mouse
lymphocyte mediated immunityGO:00024491390.908
Mouse
erythrocyte differentiationGO:0030218880.905
Mouse
positive regulation of peptidyl tyrosine phosphorylationGO:0050731610.904
negative regulation of inflammatory responseGO:0050728610.904
negative regulation of t helper 1 cell differentiationGO:004562630.904
cell adhesionGO:00071553290.903
Mouse
positive regulation of protein phosphorylationGO:00019342420.902
positive regulation of reactive oxygen species metabolic processGO:2000379110.901
regulation of transferase activityGO:00513382630.900
carbohydrate metabolic processGO:00059752300.898
multicellular organism growthGO:00352641610.898
response to radiationGO:00093141650.898
t cell selectionGO:0045058340.896
Mouse
nuclear transportGO:00511691390.892
Human
regulation of t cell proliferationGO:0042129920.889
Mouse
cellular response to x rayGO:007148120.889
response to steroid hormoneGO:0048545560.889
Human Rat
negative regulation of t helper 1 type immune responseGO:000282650.884
tyrosine phosphorylation of stat5 proteinGO:004250690.884
macrophage fusionGO:003423830.883
Mouse
development of primary sexual characteristicsGO:00451371430.881
Mouse
negative regulation of syncytium formation by plasma membrane fusionGO:003424250.877
Mouse
negative regulation of alpha beta t cell differentiationGO:0046639120.875
hormone mediated signaling pathwayGO:0009755230.875
Mouse
regulation of isotype switching to ige isotypesGO:004829370.875
Mouse
leukocyte homeostasisGO:0001776790.874
Mouse
negative regulation of cell proliferationGO:00082852960.873
allantoin metabolic processGO:000025530.873
Mouse
innate immune responseGO:00450871570.872
Mouse
rhythmic processGO:00485111740.870
Mouse
immunoglobulin productionGO:0002377730.870
Mouse
somatic diversification of immunoglobulinsGO:0016445430.864
Mouse
positive regulation of t cell differentiationGO:0045582520.859
Mouse
t helper 1 cell lineage commitmentGO:000229620.857
Mouse
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002823230.852
positive regulation of t cell activationGO:00508701010.849
Mouse
positive regulation of response to woundingGO:1903036660.849
Mouse
cell activation involved in immune responseGO:00022631260.848
Mouse
regulation of protein targetingGO:1903533610.846
i kappab kinase nf kappab signalingGO:0007249850.845
regulation of tyrosine phosphorylation of stat proteinGO:0042509200.845
regulation of sequence specific dna binding transcription factor activityGO:00510901060.842
liver developmentGO:0001889660.842
layer formation in cerebral cortexGO:0021819130.836
cellular response to interleukin 6GO:007135490.835
Human
regulation of leukocyte mediated immunityGO:00027031040.833
Mouse
positive regulation of adaptive immune responseGO:0002821610.832
Mouse
mammary gland lobule developmentGO:0061377220.830
negative regulation of neuron deathGO:1901215980.830
Rat
succinate metabolic processGO:000610540.828
Mouse
positive regulation of macrophage activationGO:0043032100.828
protein autophosphorylationGO:0046777610.828
regulation of protein transportGO:00512231630.828
cellular response to organic cyclic compoundGO:0071407870.826
regulation of tyrosine phosphorylation of stat3 proteinGO:0042516100.824
negative regulation of cellular protein metabolic processGO:00322692470.821
regulation of type 2 immune responseGO:0002828180.819
Mouse
nucleotide binding oligomerization domain containing 2 signaling pathwayGO:007043160.818
negative regulation of cd4 positive alpha beta t cell activationGO:2000515100.815
cytoplasmic pattern recognition receptor signaling pathwayGO:0002753100.813
stem cell maintenanceGO:00198271300.811
regulation of interleukin 6 productionGO:0032675550.810
positive regulation of gamma delta t cell differentiationGO:004558860.807
Mouse
positive regulation of leukocyte proliferationGO:0070665730.806
Mouse
spleen developmentGO:0048536390.803
regulation of protein kinase activityGO:00458592320.802
positive regulation of dna recombinationGO:0045911170.801
Mouse
somatic diversification of immune receptorsGO:0002200530.800
Mouse
negative regulation of macrophage fusionGO:003424010.794
Mouse
positive regulation of t cell proliferationGO:0042102520.790
Mouse
regulation of cellular component biogenesisGO:00440871810.788
regulation of cd4 positive alpha beta t cell differentiationGO:0043370210.785
negative regulation of type 2 immune responseGO:000282980.783
Mouse
negative regulation of t helper cell differentiationGO:004562390.783
regulation of protein localizationGO:00328802310.781
negative regulation of molecular functionGO:00440922580.780
gland developmentGO:00487323300.777
Mouse
proteasomal protein catabolic processGO:0010498980.772
mast cell apoptotic processGO:003302450.770
Mouse
macromolecule methylationGO:00434141200.769
positive regulation of mast cell proliferationGO:007066830.767
Mouse
cellular protein catabolic processGO:00442571550.767
negative regulation of interleukin 6 productionGO:0032715170.766
progesterone metabolic processGO:004244840.765
Mouse
positive regulation of t cell anergyGO:000266940.765
response to oxygen levelsGO:0070482620.762
positive regulation of antimicrobial peptide productionGO:000222510.760
urea cycleGO:000005020.749
negative regulation of cellular amino acid metabolic processGO:004576300.746
regulation of b cell differentiationGO:0045577230.745
Mouse
positive regulation of leukocyte mediated cytotoxicityGO:0001912310.743
Mouse
tumor necrosis factor mediated signaling pathwayGO:0033209130.742
positive regulation of innate immune responseGO:0045089800.742
Mouse
negative regulation of multi organism processGO:0043901680.741
body morphogenesisGO:0010171450.736
activation of immune responseGO:00022531380.734
epithelial cell proliferationGO:00506731740.733
Mouse
t cell lineage commitmentGO:0002360130.732
Mouse
positive regulation of mapk cascadeGO:00434101700.729
cerebral cortex radially oriented cell migrationGO:0021799310.729
positive regulation of myeloid leukocyte differentiationGO:0002763260.728
Mouse
response to type i interferonGO:0034340120.727
Mouse
isotype switchingGO:0045190360.726
Mouse
regulation of neuron deathGO:19012141340.725
Rat
negative regulation of leukocyte proliferationGO:0070664460.721
t helper 2 cell differentiationGO:0045064120.721
female gamete generationGO:0007292740.721
negative regulation of peptidyl tyrosine phosphorylationGO:0050732170.719
isoleucine metabolic processGO:000654940.719
Mouse
t cell receptor signaling pathwayGO:0050852460.718
neuron apoptotic processGO:00514021420.718
positive regulation of growth hormone receptor signaling pathwayGO:006039930.716
homeostasis of number of cellsGO:00488722100.713
Mouse
gonad developmentGO:00084061410.712
Mouse
regionalizationGO:00030023370.710
epidermis developmentGO:00085441870.710
Zebrafish
mammary gland epithelium developmentGO:0061180650.709
Mouse
t helper 1 type immune responseGO:0042088250.705
Mouse
mapk cascadeGO:00001652810.702
immune response activating cell surface receptor signaling pathwayGO:0002429720.701
regulation of lymphocyte mediated immunityGO:0002706840.700
Mouse
defense response to bacteriumGO:00427421190.698
regulation of production of molecular mediator of immune responseGO:0002700650.696
Mouse
regulation of hormone levelsGO:00108172110.695
Mouse
regulation of protein import into nucleusGO:0042306520.694
positive regulation of lymphocyte activationGO:00512511400.693
Mouse
acute inflammatory responseGO:0002526410.692
Rat
regulation of antimicrobial humoral responseGO:000275930.691
negative regulation of cd4 positive alpha beta t cell differentiationGO:004337190.691
regulation of activation of jak2 kinase activityGO:001053410.684
germ cell developmentGO:00072811850.683
regulation of establishment of protein localizationGO:00702011810.683
cholesterol metabolic processGO:0008203560.683
regulation of carbohydrate metabolic processGO:0006109750.682
regulation of t helper cell differentiationGO:0045622140.679
negative regulation of erythrocyte differentiationGO:004564750.679
Mouse
b cell activation involved in immune responseGO:0002312500.677
Mouse
regulation of mast cell proliferationGO:007066640.677
Mouse
nik nf kappab signalingGO:0038061140.676
macrophage activationGO:0042116270.675
negative regulation of t cell proliferationGO:0042130380.673
oxaloacetate metabolic processGO:000610750.673
Mouse
cellular response to lipopolysaccharideGO:0071222770.673
Mouse
epithelial cell developmentGO:00020641590.673
luteinizationGO:000155380.672
Mouse
positive regulation of apoptotic process involved in mammary gland involutionGO:006005840.672
leukocyte proliferationGO:00706611720.672
Mouse
regulation of defense response to virus by hostGO:005069180.672
alpha amino acid metabolic processGO:1901605590.670
Mouse
ovulationGO:0030728150.670
protein catabolic processGO:00301632210.662
positive regulation of lymphocyte proliferationGO:0050671700.661
Mouse
response to peptideGO:19016521360.661
negative regulation of inflammatory response to antigenic stimulusGO:0002862100.658
radial glia guided migration of purkinje cellGO:002194260.657
negative regulation of tyrosine phosphorylation of stat proteinGO:004253230.654
response to endoplasmic reticulum stressGO:0034976530.650
response to dsrnaGO:0043331300.649
Mouse
response to drugGO:0042493750.645
Rat
cytokine biosynthetic processGO:0042089680.643
Mouse
positive regulation of alpha beta t cell differentiationGO:0046638280.640
negative regulation of mast cell apoptotic processGO:003302640.639
Mouse
ovulation cycleGO:0042698590.637
Mouse
antibacterial peptide productionGO:000277820.636
fibroblast migrationGO:0010761210.635
regulation of neuron apoptotic processGO:00435231220.635
somatic diversification of immunoglobulins involved in immune responseGO:0002208360.634
Mouse
regulation of cytokine production involved in immune responseGO:0002718260.631
negative regulation of phosphorus metabolic processGO:00105631840.631
proteolysis involved in cellular protein catabolic processGO:00516031470.630
t helper 1 cell differentiationGO:0045063130.629
Mouse
positive regulation of apoptotic signaling pathwayGO:2001235950.627
cellular response to oxidative stressGO:0034599760.627
antigen receptor mediated signaling pathwayGO:0050851640.626
cellular response to growth factor stimulusGO:00713631970.622
Mouse
myeloid leukocyte activationGO:0002274830.622
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.617
leukocyte mediated immunityGO:00024431740.616
Mouse
regulation of b cell mediated immunityGO:0002712370.614
Mouse
lymphocyte anergyGO:000224940.613
positive regulation of intracellular transportGO:0032388700.612
positive regulation of natural killer cell mediated immunityGO:0002717160.611
Mouse
positive regulation of osteoblast differentiationGO:0045669340.610
interleukin 27 mediated signaling pathwayGO:007010610.606
digestive tract developmentGO:00485651900.600
Zebrafish
regulation of nucleocytoplasmic transportGO:0046822730.600
regulation of secretion by cellGO:19035302490.599
positive regulation of b cell mediated immunityGO:0002714260.598
Mouse
negative regulation of cellular component organizationGO:00511291940.598
Mouse
response to lithium ionGO:0010226100.595
t cell differentiation in thymusGO:0033077770.595
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.592
Mouse
glycolytic processGO:0006096200.590
cellular response to inorganic substanceGO:0071241370.590
placenta developmentGO:00018901400.581
negative regulation of phosphate metabolic processGO:00459361840.579
regulation of defense response to virusGO:0050688180.578
regulation of cellular response to stressGO:00801351590.578
cellular response to dna damage stimulusGO:00069742070.578
cell type specific apoptotic processGO:00972852680.576
Mouse
activation of mapkk activityGO:0000186150.573
response to granulocyte macrophage colony stimulating factorGO:009701230.571
Mouse
reactive nitrogen species metabolic processGO:200105700.569
blastoderm segmentationGO:0007350130.562
lung developmentGO:00303241640.562
intrinsic apoptotic signaling pathwayGO:00971931320.561
regulation of cell migrationGO:00303342190.558
positive regulation of protein complex assemblyGO:0031334450.553
positive regulation of protein transportGO:0051222930.551
t cell anergyGO:000287040.551
negative regulation of t helper 2 cell differentiationGO:004562940.550
negative regulation of lymphocyte proliferationGO:0050672450.544
dna recombinationGO:0006310920.543
Mouse
segmentationGO:0035282930.542
dna alkylationGO:0006305430.542
dna methylationGO:0006306430.537
cd4 positive or cd8 positive alpha beta t cell lineage commitmentGO:004336980.536
Mouse
negative regulation of response to cytokine stimulusGO:006076190.535
regulation of mitotic cell cycleGO:00073461260.534
Mouse
positive regulation of apoptotic processGO:00430652170.534
Mouse
regulation of response to biotic stimulusGO:0002831380.531
regulation of peptidyl serine phosphorylationGO:0033135390.530
covalent chromatin modificationGO:00165691630.529
glial cell differentiationGO:00100011310.527
histone modificationGO:00165701590.525
regulation of natural killer cell mediated immunityGO:0002715190.524
Mouse
cellular carbohydrate metabolic processGO:00442621190.522
myeloid leukocyte differentiationGO:00025731190.520
Mouse
positive regulation of immature t cell proliferationGO:003309140.519
negative regulation of cellular amine metabolic processGO:003323910.519
regulation of innate immune responseGO:0045088910.514
Mouse
cell fate commitmentGO:00451652100.514
Mouse
epidermal growth factor receptor signaling pathwayGO:0007173280.509
transformed cell apoptotic processGO:000692730.509
cellular response to metal ionGO:0071248310.508
axon ensheathmentGO:0008366760.504
reactive oxygen species metabolic processGO:0072593840.503
Rat
lymphocyte proliferationGO:00466511640.501
Mouse
regulation of macrophage fusionGO:003423930.501
Mouse
negative regulation of lymphocyte apoptotic processGO:0070229240.500
positive regulation of cellular component biogenesisGO:0044089940.500
cellular response to interleukin 18GO:007135130.498
phagocytosisGO:0006909660.498
response to tumor necrosis factorGO:0034612260.498
response to estrogenGO:0043627240.498
Human Rat
organonitrogen compound biosynthetic processGO:19015661920.496
Rat
t helper 17 cell lineage commitmentGO:007254040.496
apoptotic signaling pathwayGO:00971903060.494
modulation by virus of host morphology or physiologyGO:001904830.494
female sex differentiationGO:0046660840.491
Mouse
response to alkaloidGO:0043279340.491
negative regulation of protein modification processGO:00314001630.489
steroid metabolic processGO:00082021190.489
Mouse
stem cell developmentGO:00488642190.489
cellular macromolecule catabolic processGO:00442652060.487
positive regulation of myeloid cell differentiationGO:0045639430.487
Mouse
neuronal action potentialGO:0019228540.486
leukocyte activation involved in immune responseGO:00023661260.482
Mouse
positive regulation of defense response to virus by hostGO:000223060.480
chromatin modificationGO:00165681870.478
intrinsic apoptotic signaling pathway in response to oxidative stressGO:0008631190.478
positive regulation of kinase activityGO:00336741550.476
response to heatGO:0009408270.475
cytokine metabolic processGO:0042107710.472
Mouse
hindbrain radial glia guided cell migrationGO:0021932120.471
positive regulation of chemokine productionGO:0032722220.471
pattern recognition receptor signaling pathwayGO:0002221470.469
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.469
regulation of cell adhesionGO:00301551540.467
Mouse
activation of innate immune responseGO:0002218560.461
regulation of multi organism processGO:00439001110.460
positive regulation of cd4 positive alpha beta t cell differentiationGO:0043372140.458
positive regulation of reactive oxygen species biosynthetic processGO:190342820.457
positive regulation of cell proliferation involved in heart valve morphogenesisGO:000325110.455
cellular response to granulocyte macrophage colony stimulating factor stimulusGO:009701130.452
Mouse
gliogenesisGO:00420631410.450
regulation of defense response to bacteriumGO:190042430.449
positive regulation of jak stat cascadeGO:0046427220.448
positive regulation of cell adhesionGO:0045785800.448
fibroblast proliferationGO:0048144350.446
regulation of macrophage differentiationGO:004564990.446
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217640.446
lipid localizationGO:00108761260.445
Mouse
growth hormone receptor signaling pathwayGO:006039670.444
macrophage differentiationGO:0030225200.441
negative regulation of response to woundingGO:1903035770.441
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238340.440
cellular response to interleukin 15GO:007135020.436
mucosal associated lymphoid tissue developmentGO:0048537120.435
Mouse
positive regulation of transcription by galactoseGO:000041110.433
mammary gland epithelial cell proliferationGO:0033598240.433
Mouse
urea metabolic processGO:001962730.432
regulation of transforming growth factor beta2 productionGO:003290920.431
dendritic cell cytokine productionGO:000237130.431
regulation of cytoplasmic transportGO:19036491120.431
organ growthGO:00352651170.430
body fluid secretionGO:0007589530.429
Mouse
response to insulinGO:00328681000.428
digestive system developmentGO:00551232000.427
Zebrafish
protein localization to organelleGO:00333651850.426
Human
cellular carbohydrate catabolic processGO:0044275150.426
regulation of t cell anergyGO:000266740.426
stem cell differentiationGO:00488632680.425
positive regulation of interferon gamma productionGO:0032729390.423
interleukin 2 mediated signaling pathwayGO:003811020.423
regulation of angiogenesisGO:0045765810.421
urogenital system developmentGO:00016552610.420
Mouse
natural killer cell mediated immunityGO:0002228290.419
Mouse
myd88 dependent toll like receptor signaling pathwayGO:000275570.414
positive regulation of cytoplasmic transportGO:1903651400.412
cellular response to type i interferonGO:0071357100.412
Mouse
regulation of protein import into nucleus translocationGO:003315820.411
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555500.410
negative regulation of chemokine biosynthetic processGO:004507920.408
immunoglobulin production involved in immunoglobulin mediated immune responseGO:0002381430.407
Mouse
regulation of reactive oxygen species biosynthetic processGO:190342620.406
Rat
activation induced cell death of t cellsGO:0006924100.401
ossificationGO:00015032160.397
positive regulation of fibroblast proliferationGO:0048146200.395
positive regulation of mirna metabolic processGO:200063010.394
hormone metabolic processGO:0042445860.394
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126930.393
response to oxidative stressGO:00069791230.392

Stat3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.928
disease of cellular proliferationDOID:1456600.928
organ system cancerDOID:005068600.928
immune system cancerDOID:006008300.776
disease of metabolismDOID:001466700.472
inherited metabolic disorderDOID:65500.472
hematologic cancerDOID:253100.457