IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Stim2

stromal interaction molecule 2

Entrez: 116873
Ensembl: ENSMUSG00000039156
UniProtKB: P83093
UniProtKB: A5CVE4

Process Predictions
Disease Predictions

Stim2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
store operated calcium entry	GO:0002115	7	0.946	Mouse Worm Fly
regulation of engulfment of apoptotic cell	GO:1901074	2	0.724	Worm
cation transport	GO:0006812	399	0.587	Human Mouse Worm Fly
regulation of ion transmembrane transporter activity	GO:0032412	54	0.573	Human Worm Fly
transmembrane transport	GO:0055085	412	0.484	Human Worm Fly
positive regulation of nfat protein import into nucleus	GO:0051533	1	0.478	Fly
regulation of ion transmembrane transport	GO:0034765	119	0.429	Human Worm Fly
regulation of transmembrane transport	GO:0034762	128	0.426	Human Worm Fly
regulation of store operated calcium entry	GO:2001256	4	0.360
response to calcium ion	GO:0051592	20	0.358	Fly
nucleobase containing small molecule metabolic process	GO:0055086	352	0.322
organonitrogen compound catabolic process	GO:1901565	264	0.318
cytoplasmic transport	GO:0016482	234	0.313	Fly
apoptotic signaling pathway	GO:0097190	306	0.312
muscle system process	GO:0003012	141	0.277	Worm
cellular response to arsenic containing substance	GO:0071243	4	0.276
membrane organization	GO:0061024	245	0.261	Worm
regulation of purine nucleotide catabolic process	GO:0033121	122	0.259
regulation of cellular catabolic process	GO:0031329	242	0.250
intracellular protein transport	GO:0006886	204	0.249	Fly
regulation of muscle system process	GO:0090257	80	0.249	Worm
purine nucleoside metabolic process	GO:0042278	241	0.249
positive regulation of apoptotic process	GO:0043065	217	0.248
regulation of ion transport	GO:0043269	215	0.246	Human Worm Fly
intrinsic apoptotic signaling pathway	GO:0097193	132	0.240
nucleotide metabolic process	GO:0009117	332	0.239
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.237
nucleoside catabolic process	GO:0009164	206	0.223
negative regulation of phosphorylation	GO:0042326	166	0.220
positive regulation of mitochondrion organization	GO:0010822	17	0.217
regulation of protein localization	GO:0032880	231	0.214	Fly
regulation of purine nucleotide metabolic process	GO:1900542	169	0.214
regulation of apoptotic signaling pathway	GO:2001233	197	0.210
regulation of protein transport	GO:0051223	163	0.209	Fly
divalent metal ion transport	GO:0070838	172	0.207	Human Mouse Worm Fly
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.205
cellular nitrogen compound catabolic process	GO:0044270	280	0.204
positive regulation of engulfment of apoptotic cell	GO:1901076	1	0.202	Worm
response to ischemia	GO:0002931	14	0.201
purine containing compound metabolic process	GO:0072521	311	0.200
regulation of hydrolase activity	GO:0051336	246	0.198
purine containing compound catabolic process	GO:0072523	213	0.191
response to oxidative stress	GO:0006979	123	0.186
release of cytochrome c from mitochondria	GO:0001836	23	0.185
positive regulation of intracellular transport	GO:0032388	70	0.183	Fly
regulation of intracellular protein transport	GO:0033157	82	0.183	Fly
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.183
purine nucleotide catabolic process	GO:0006195	211	0.177
ribonucleoside metabolic process	GO:0009119	245	0.176
positive regulation of cell death	GO:0010942	224	0.174
regulation of protein targeting	GO:1903533	61	0.171	Fly
nucleocytoplasmic transport	GO:0006913	139	0.169	Fly
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.168
regulation of nucleotide metabolic process	GO:0006140	169	0.167
nucleoside phosphate catabolic process	GO:1901292	222	0.167
regulation of vesicle mediated transport	GO:0060627	139	0.166	Worm
cellular ketone metabolic process	GO:0042180	84	0.164
endocytosis	GO:0006897	168	0.161	Worm
regulation of intracellular transport	GO:0032386	159	0.160	Fly
ribonucleotide catabolic process	GO:0009261	208	0.160
necroptotic process	GO:0070266	21	0.159
purine ribonucleotide metabolic process	GO:0009150	290	0.157
organic cyclic compound catabolic process	GO:1901361	295	0.156
organophosphate catabolic process	GO:0046434	232	0.156
positive regulation of phagocytosis engulfment	GO:0060100	3	0.155	Worm
ribose phosphate metabolic process	GO:0019693	291	0.155
phagocytosis	GO:0006909	66	0.154	Worm
glycosyl compound catabolic process	GO:1901658	206	0.154
positive regulation of programmed cell death	GO:0043068	218	0.152
regulation of nucleoside metabolic process	GO:0009118	130	0.152
muscle contraction	GO:0006936	101	0.148	Worm
cellular response to inorganic substance	GO:0071241	37	0.147
protein localization to nucleus	GO:0034504	121	0.143	Fly
cellular response to oxidative stress	GO:0034599	76	0.142
regulation of organelle organization	GO:0033043	289	0.141
regulation of protein import into nucleus	GO:0042306	52	0.141	Fly
regulation of nucleocytoplasmic transport	GO:0046822	73	0.140	Fly
regulation of neuron differentiation	GO:0045664	281	0.138
apoptotic mitochondrial changes	GO:0008637	48	0.138
regulation of protein kinase activity	GO:0045859	232	0.138
ribonucleotide metabolic process	GO:0009259	291	0.137
carbohydrate derivative catabolic process	GO:1901136	231	0.135
regulation of cellular amine metabolic process	GO:0033238	20	0.135
nucleoside triphosphate metabolic process	GO:0009141	230	0.135
inorganic ion transmembrane transport	GO:0098660	234	0.133	Human Worm Fly
calcium ion transport	GO:0006816	159	0.132	Human Mouse Worm Fly
purine ribonucleotide catabolic process	GO:0009154	208	0.132
regulation of system process	GO:0044057	200	0.130	Worm
nuclear transport	GO:0051169	139	0.128	Fly
response to reactive oxygen species	GO:0000302	56	0.127
positive regulation of muscle contraction	GO:0045933	10	0.126	Worm
negative regulation of phosphate metabolic process	GO:0045936	184	0.125
positive regulation of cytoplasmic transport	GO:1903651	40	0.125	Fly
negative regulation of cellular component organization	GO:0051129	194	0.124
muscle tissue development	GO:0060537	308	0.122
regulation of cytoplasmic transport	GO:1903649	112	0.121	Fly
nucleoside metabolic process	GO:0009116	246	0.120
heterocycle catabolic process	GO:0046700	280	0.119
regulation of cellular amino acid metabolic process	GO:0006521	5	0.119
purine ribonucleoside catabolic process	GO:0046130	205	0.117
atp catabolic process	GO:0006200	55	0.116
response to organonitrogen compound	GO:0010243	246	0.116
regulation of metal ion transport	GO:0010959	106	0.115	Human Worm Fly
positive regulation of protein transport	GO:0051222	93	0.114	Fly
nucleoside triphosphate catabolic process	GO:0009143	205	0.113
gland development	GO:0048732	330	0.112
ribonucleoside catabolic process	GO:0042454	206	0.112
response to inorganic substance	GO:0010035	96	0.111	Fly
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.110
aromatic compound catabolic process	GO:0019439	286	0.110
cellular amine metabolic process	GO:0044106	44	0.108
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.108
positive regulation of apoptotic cell clearance	GO:2000427	3	0.106	Worm
nucleotide catabolic process	GO:0009166	217	0.105
regulation of transcription factor import into nucleus	GO:0042990	24	0.105	Fly
necrotic cell death	GO:0070265	30	0.104
positive regulation of organelle organization	GO:0010638	128	0.102
protein import into nucleus	GO:0006606	95	0.102	Fly
skeletal system development	GO:0001501	356	0.101
protein targeting	GO:0006605	143	0.101	Fly
positive regulation of phagocytosis	GO:0050766	26	0.100	Worm
positive regulation of protein import into nucleus	GO:0042307	26	0.100	Fly
amine metabolic process	GO:0009308	45	0.099
regulation of endocytosis	GO:0030100	69	0.098	Worm
positive regulation of protein modification process	GO:0031401	299	0.098
cell adhesion	GO:0007155	329	0.096
synaptic transmission	GO:0007268	329	0.095
axon guidance	GO:0007411	141	0.095
leukocyte differentiation	GO:0002521	342	0.095
negative regulation of molecular function	GO:0044092	258	0.092
cation homeostasis	GO:0055080	212	0.091	Human
positive regulation of cellular catabolic process	GO:0031331	148	0.091
regulation of cation channel activity	GO:2001257	22	0.091	Human Worm Fly
positive regulation of cell development	GO:0010720	237	0.091
negative regulation of intracellular signal transduction	GO:1902532	167	0.091
regulation of calcium ion transport	GO:0051924	69	0.090	Human Worm Fly
inorganic cation transmembrane transport	GO:0098662	207	0.090	Human Worm Fly
generation of precursor metabolites and energy	GO:0006091	103	0.090
chemotaxis	GO:0006935	247	0.090
negative regulation of phosphorus metabolic process	GO:0010563	184	0.089
nucleoside monophosphate metabolic process	GO:0009123	85	0.088
nucleoside phosphate metabolic process	GO:0006753	338	0.087
cellular amino acid metabolic process	GO:0006520	103	0.087
positive regulation of protein localization to nucleus	GO:1900182	30	0.086	Fly
regulation of cell migration	GO:0030334	219	0.086
positive regulation of endocytosis	GO:0045807	42	0.082	Worm
negative regulation of organelle organization	GO:0010639	90	0.081
positive regulation of ion transmembrane transporter activity	GO:0032414	15	0.081	Human Worm Fly
regulation of store operated calcium channel activity	GO:1901339	1	0.080	Human Worm Fly
cellular lipid metabolic process	GO:0044255	323	0.079
cation transmembrane transport	GO:0098655	266	0.079	Human Worm Fly
glycosyl compound metabolic process	GO:1901657	246	0.079
positive regulation of hydrolase activity	GO:0051345	148	0.079
regulation of mitochondrion organization	GO:0010821	27	0.079
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.078
positive regulation of transcription factor import into nucleus	GO:0042993	8	0.078	Fly
mitochondrial membrane organization	GO:0007006	26	0.078
regulation of secretion	GO:0051046	274	0.078
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.078
ion transmembrane transport	GO:0034220	361	0.076	Human Worm Fly
skeletal muscle organ development	GO:0060538	163	0.076
ovulation	GO:0030728	15	0.075	Worm
positive regulation of release of cytochrome c from mitochondria	GO:0090200	5	0.075
regulation of cell motility	GO:2000145	236	0.074
negative regulation of cell proliferation	GO:0008285	296	0.074
immune effector process	GO:0002252	321	0.073
stem cell development	GO:0048864	219	0.073
regulation of release of cytochrome c from mitochondria	GO:0090199	11	0.072
axonogenesis	GO:0007409	274	0.071
regulation of cytokine production	GO:0001817	266	0.071
regulation of nucleotide catabolic process	GO:0030811	122	0.071
regulation of anatomical structure size	GO:0090066	178	0.071
regulation of secretion by cell	GO:1903530	249	0.071
positive regulation of protein phosphorylation	GO:0001934	242	0.071
striated muscle tissue development	GO:0014706	293	0.071
forebrain development	GO:0030900	302	0.071
response to metal ion	GO:0010038	47	0.070	Fly
oxidation reduction process	GO:0055114	342	0.070
regulation of smooth muscle contraction	GO:0006940	22	0.069	Worm
camera type eye development	GO:0043010	266	0.069
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.069
cytokine production	GO:0001816	319	0.069
regulation of transporter activity	GO:0032409	57	0.069	Human Worm Fly
negative regulation of release of cytochrome c from mitochondria	GO:0090201	6	0.068
positive regulation of calcium ion transport	GO:0051928	27	0.067	Human Worm Fly
stem cell differentiation	GO:0048863	268	0.067
positive regulation of ion transport	GO:0043270	65	0.067	Human Worm Fly
purine nucleoside catabolic process	GO:0006152	205	0.066
regulation of cellular ketone metabolic process	GO:0010565	66	0.066
positive regulation of cellular amine metabolic process	GO:0033240	5	0.065
protein localization to organelle	GO:0033365	185	0.065	Fly
cellular homeostasis	GO:0019725	240	0.064	Human
regulation of cell projection organization	GO:0031344	206	0.064
maintenance of location	GO:0051235	89	0.064
positive regulation of nucleocytoplasmic transport	GO:0046824	30	0.064	Fly
regulation of ras protein signal transduction	GO:0046578	114	0.063
regulation of necrotic cell death	GO:0010939	13	0.063
regulation of phagocytosis	GO:0050764	33	0.062	Worm
regulation of defense response	GO:0031347	233	0.062
epithelial tube morphogenesis	GO:0060562	303	0.062
negative regulation of protein metabolic process	GO:0051248	282	0.061
carbohydrate metabolic process	GO:0005975	230	0.060
cellular chemical homeostasis	GO:0055082	215	0.060	Human
rho protein signal transduction	GO:0007266	32	0.060
regulation of inflammatory response	GO:0050727	147	0.059
nucleoside monophosphate catabolic process	GO:0009125	59	0.059
ras protein signal transduction	GO:0007265	77	0.058
regulation of mapk cascade	GO:0043408	248	0.058
receptor mediated endocytosis	GO:0006898	51	0.058	Worm
response to radiation	GO:0009314	165	0.057
negative regulation of cellular catabolic process	GO:0031330	47	0.057
response to growth factor	GO:0070848	198	0.057
skin development	GO:0043588	220	0.057
programmed necrotic cell death	GO:0097300	28	0.056
cellular ion homeostasis	GO:0006873	165	0.056	Human
epidermis development	GO:0008544	187	0.056
regulation of proteolysis	GO:0030162	164	0.055
digestive tract development	GO:0048565	190	0.055
negative regulation of immune system process	GO:0002683	209	0.055
small gtpase mediated signal transduction	GO:0007264	97	0.054
lymphocyte differentiation	GO:0030098	242	0.054
negative regulation of purine nucleotide catabolic process	GO:0033122	9	0.054
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.053
regulation of cellular component biogenesis	GO:0044087	181	0.053
carbohydrate derivative biosynthetic process	GO:1901137	183	0.053
extrinsic apoptotic signaling pathway	GO:0097191	126	0.053
activation of store operated calcium channel activity	GO:0032237	1	0.053	Human Fly
neuron death	GO:0070997	154	0.053
regulation of hormone levels	GO:0010817	211	0.053
regulation of cellular response to stress	GO:0080135	159	0.053
negative regulation of hydrolase activity	GO:0051346	71	0.052
protein modification by small protein conjugation or removal	GO:0070647	207	0.052
skeletal system morphogenesis	GO:0048705	203	0.052
regulation of kinase activity	GO:0043549	249	0.051
epithelial cell proliferation	GO:0050673	174	0.051
t cell activation	GO:0042110	289	0.051
purine nucleotide metabolic process	GO:0006163	302	0.051
response to molecule of bacterial origin	GO:0002237	143	0.051
response to lipopolysaccharide	GO:0032496	128	0.050
dna metabolic process	GO:0006259	303	0.050
cellular response to hormone stimulus	GO:0032870	150	0.050
wnt signaling pathway	GO:0016055	188	0.050
regulation of organ morphogenesis	GO:2000027	144	0.050
negative regulation of cellular amine metabolic process	GO:0033239	1	0.050
nitrogen compound transport	GO:0071705	271	0.050
cell type specific apoptotic process	GO:0097285	268	0.049
organic hydroxy compound metabolic process	GO:1901615	203	0.049
positive regulation of gtp catabolic process	GO:0033126	85	0.049
blood vessel morphogenesis	GO:0048514	285	0.049
positive regulation of growth	GO:0045927	104	0.049
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.049
covalent chromatin modification	GO:0016569	163	0.049
sensory organ morphogenesis	GO:0090596	242	0.049
regulation of neuron apoptotic process	GO:0043523	122	0.049
myeloid cell differentiation	GO:0030099	233	0.048
morphogenesis of a branching epithelium	GO:0061138	193	0.048
regulation of neuron projection development	GO:0010975	169	0.048
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.048
fat cell differentiation	GO:0045444	160	0.048
atp metabolic process	GO:0046034	75	0.048
positive regulation of cell migration	GO:0030335	109	0.048
peptidyl amino acid modification	GO:0018193	336	0.048
digestive system development	GO:0055123	200	0.048
placenta development	GO:0001890	140	0.048
positive regulation of nervous system development	GO:0051962	221	0.047
regulation of response to wounding	GO:1903034	189	0.047
protein maturation	GO:0051604	176	0.047
response to peptide	GO:1901652	136	0.047
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.047
regulation of protein serine threonine kinase activity	GO:0071900	157	0.047
heart morphogenesis	GO:0003007	178	0.046
positive regulation of transmembrane transport	GO:0034764	29	0.046	Human Worm Fly
locomotory behavior	GO:0007626	195	0.046
regulation of establishment of protein localization	GO:0070201	181	0.046	Fly
actin cytoskeleton organization	GO:0030036	220	0.046
negative regulation of nervous system development	GO:0051961	156	0.046
regulation of t cell activation	GO:0050863	170	0.046
negative regulation of protein phosphorylation	GO:0001933	126	0.046
neuron projection guidance	GO:0097485	141	0.046
regulation of lymphocyte activation	GO:0051249	240	0.045
peptidyl tyrosine phosphorylation	GO:0018108	143	0.045
homeostasis of number of cells	GO:0048872	210	0.045
membrane invagination	GO:0010324	17	0.045	Worm
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.044
morphogenesis of a branching structure	GO:0001763	203	0.044
telencephalon development	GO:0021537	186	0.044
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.044
peptide transport	GO:0015833	133	0.044
regulation of homeostatic process	GO:0032844	182	0.044
transcription factor import into nucleus	GO:0042991	26	0.044	Fly
positive regulation of mapk cascade	GO:0043410	170	0.044
hormone secretion	GO:0046879	128	0.043
negative regulation of cellular protein metabolic process	GO:0032269	247	0.043
mitochondrion organization	GO:0007005	134	0.043
regulation of leukocyte differentiation	GO:1902105	159	0.042
carbohydrate homeostasis	GO:0033500	128	0.042
mapk cascade	GO:0000165	281	0.042
myotube differentiation	GO:0014902	105	0.042
response to organic cyclic compound	GO:0014070	198	0.042
rhythmic process	GO:0048511	174	0.042
regulation of cell activation	GO:0050865	289	0.042
chromatin modification	GO:0016568	187	0.041
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.041
g protein coupled receptor signaling pathway	GO:0007186	243	0.041
dendrite development	GO:0016358	115	0.041
regulation of mitochondrial membrane permeability	GO:0046902	17	0.041
ossification	GO:0001503	216	0.041
protein processing	GO:0016485	163	0.040
cellular metal ion homeostasis	GO:0006875	151	0.040	Human
negative regulation of purine nucleotide metabolic process	GO:1900543	16	0.040
myeloid leukocyte differentiation	GO:0002573	119	0.040
peptidyl tyrosine modification	GO:0018212	145	0.040
cellular response to metal ion	GO:0071248	31	0.040
regulation of cell adhesion	GO:0030155	154	0.040
cognition	GO:0050890	149	0.040
amide transport	GO:0042886	138	0.039
lipid biosynthetic process	GO:0008610	179	0.039
positive regulation of secretion	GO:0051047	130	0.039
macromolecule catabolic process	GO:0009057	281	0.039
cellular macromolecule catabolic process	GO:0044265	206	0.039
muscle cell differentiation	GO:0042692	261	0.039
chromatin organization	GO:0006325	206	0.039
positive regulation of nucleotide catabolic process	GO:0030813	88	0.038
reactive oxygen species metabolic process	GO:0072593	84	0.038
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.038
t cell differentiation	GO:0030217	174	0.038
synapse organization	GO:0050808	125	0.038
regulation of calcium ion transmembrane transporter activity	GO:1901019	20	0.038	Human Worm Fly
regulation of transferase activity	GO:0051338	263	0.037
adaptive immune response	GO:0002250	155	0.037
negative regulation of protein modification process	GO:0031400	163	0.037
embryonic organ morphogenesis	GO:0048562	276	0.037
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.037	Human
development of primary sexual characteristics	GO:0045137	143	0.037
branching morphogenesis of an epithelial tube	GO:0048754	159	0.037
positive regulation of secretion by cell	GO:1903532	114	0.036
negative regulation of mitochondrion organization	GO:0010823	9	0.036
activation of immune response	GO:0002253	138	0.036
urogenital system development	GO:0001655	261	0.036
regulation of gtp catabolic process	GO:0033124	113	0.036
response to peptide hormone	GO:0043434	127	0.036
positive regulation of kinase activity	GO:0033674	155	0.035
regulation of epithelial cell proliferation	GO:0050678	141	0.035
mitochondrial transport	GO:0006839	36	0.035
negative regulation of atpase activity	GO:0032780	2	0.035
stress activated protein kinase signaling cascade	GO:0031098	81	0.035
striated muscle cell development	GO:0055002	125	0.035
morphogenesis of embryonic epithelium	GO:0016331	159	0.035
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.035
renal system development	GO:0072001	225	0.035
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.035
cellular response to cytokine stimulus	GO:0071345	189	0.035
establishment of protein localization to organelle	GO:0072594	118	0.035	Fly
regulation of neuron death	GO:1901214	134	0.034
cellular response to growth factor stimulus	GO:0071363	197	0.034
angiogenesis	GO:0001525	201	0.034
divalent inorganic cation homeostasis	GO:0072507	138	0.034	Human
central nervous system neuron differentiation	GO:0021953	162	0.034
kidney development	GO:0001822	213	0.034
developmental maturation	GO:0021700	193	0.034
detection of stimulus	GO:0051606	84	0.034	Fly
immune response regulating signaling pathway	GO:0002764	125	0.034
cellular response to calcium ion	GO:0071277	14	0.034
positive regulation of ras gtpase activity	GO:0032320	65	0.033
negative regulation of cell development	GO:0010721	169	0.033
neural tube development	GO:0021915	160	0.033
modification dependent protein catabolic process	GO:0019941	133	0.033
negative regulation of transferase activity	GO:0051348	85	0.033
regulation of calcium ion transmembrane transport	GO:1903169	20	0.032	Human Worm Fly
regulation of synaptic plasticity	GO:0048167	87	0.032
regulation of chemotaxis	GO:0050920	53	0.032
peptide hormone secretion	GO:0030072	109	0.032
alcohol metabolic process	GO:0006066	116	0.032
protein modification by small protein conjugation	GO:0032446	187	0.032
positive regulation of neuron projection development	GO:0010976	79	0.032
sensory perception	GO:0007600	245	0.032
mitotic cell cycle	GO:0000278	195	0.032
mitotic cell cycle process	GO:1903047	159	0.032
negative regulation of nucleoside metabolic process	GO:0045978	11	0.032
positive regulation of cell motility	GO:2000147	116	0.032
positive regulation of proteolysis	GO:0045862	85	0.032
positive regulation of transporter activity	GO:0032411	17	0.031	Human Worm Fly
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.031
muscle cell development	GO:0055001	133	0.031
digestive tract morphogenesis	GO:0048546	147	0.031
germ cell development	GO:0007281	185	0.031
positive regulation of gtpase activity	GO:0043547	85	0.031
respiratory system development	GO:0060541	190	0.031
neuron migration	GO:0001764	122	0.031
neuron apoptotic process	GO:0051402	142	0.031
glucose homeostasis	GO:0042593	128	0.031
regulation of cellular component size	GO:0032535	121	0.030
positive regulation of nucleoside metabolic process	GO:0045979	91	0.030
cellular protein catabolic process	GO:0044257	155	0.030
multicellular organism growth	GO:0035264	161	0.030
regulation of membrane potential	GO:0042391	192	0.030
protein catabolic process	GO:0030163	221	0.030
regulation of membrane permeability	GO:0090559	18	0.030
posttranscriptional regulation of gene expression	GO:0010608	155	0.030
b cell activation	GO:0042113	161	0.030
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.030
segmentation	GO:0035282	93	0.030
jnk cascade	GO:0007254	72	0.030
cell growth	GO:0016049	130	0.030
negative regulation of nucleotide catabolic process	GO:0030812	9	0.030
cellular response to organonitrogen compound	GO:0071417	145	0.029
calcium ion homeostasis	GO:0055074	127	0.029	Human
regulation of adaptive immune response	GO:0002819	90	0.029
dephosphorylation	GO:0016311	129	0.029
cellular response to dna damage stimulus	GO:0006974	207	0.029
leukocyte migration	GO:0050900	124	0.029
spermatogenesis	GO:0007283	284	0.029
regulation of ras gtpase activity	GO:0032318	88	0.028
bmp signaling pathway	GO:0030509	93	0.028
inflammatory response	GO:0006954	244	0.028
protein ubiquitination	GO:0016567	171	0.028
cell fate commitment	GO:0045165	210	0.028
respiratory tube development	GO:0030323	167	0.028
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.028
learning or memory	GO:0007611	148	0.028
response to insulin	GO:0032868	100	0.028
cellular protein complex assembly	GO:0043623	116	0.028
multicellular organismal signaling	GO:0035637	91	0.028
insulin secretion	GO:0030073	89	0.028
gtp catabolic process	GO:0006184	143	0.028
divalent inorganic cation transport	GO:0072511	178	0.028	Human Mouse Worm Fly
positive regulation of nucleotide metabolic process	GO:0045981	114	0.028
guanosine containing compound metabolic process	GO:1901068	144	0.028
regionalization	GO:0003002	337	0.027
regulation of atp metabolic process	GO:1903578	17	0.027
glycoprotein metabolic process	GO:0009100	116	0.027
embryonic epithelial tube formation	GO:0001838	130	0.027
cellular response to lipid	GO:0071396	145	0.027
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.027
peptidyl serine modification	GO:0018209	83	0.027
negative regulation of neuron death	GO:1901215	98	0.027
negative regulation of cell cycle	GO:0045786	123	0.027
cellular response to peptide	GO:1901653	92	0.027
leukocyte activation involved in immune response	GO:0002366	126	0.027
regulation of hormone secretion	GO:0046883	88	0.027
peptidyl serine phosphorylation	GO:0018105	74	0.027
endomembrane system organization	GO:0010256	147	0.026
carbohydrate transport	GO:0008643	62	0.026
hydrogen transport	GO:0006818	35	0.026
cellular response to organic cyclic compound	GO:0071407	87	0.026
extracellular matrix organization	GO:0030198	147	0.026
regulation of protein processing	GO:0070613	96	0.026
innate immune response	GO:0045087	157	0.026
lymphocyte mediated immunity	GO:0002449	139	0.026
negative regulation of neuron apoptotic process	GO:0043524	92	0.026
mesenchymal cell differentiation	GO:0048762	107	0.026
anatomical structure homeostasis	GO:0060249	145	0.026
mesoderm development	GO:0007498	100	0.026
metal ion homeostasis	GO:0055065	189	0.026	Human
leukocyte mediated immunity	GO:0002443	174	0.026
organonitrogen compound biosynthetic process	GO:1901566	192	0.025
regulation of multi organism process	GO:0043900	111	0.025
compound eye development	GO:0048749	1	0.025
positive regulation of lymphocyte activation	GO:0051251	140	0.025
transmission of nerve impulse	GO:0019226	76	0.025
meiotic cell cycle	GO:0051321	122	0.025
peptide secretion	GO:0002790	114	0.025
gliogenesis	GO:0042063	141	0.025
neural tube formation	GO:0001841	108	0.025
multicellular organismal homeostasis	GO:0048871	164	0.025
proton transport	GO:0015992	35	0.025
canonical wnt signaling pathway	GO:0060070	130	0.025
negative regulation of nucleotide metabolic process	GO:0045980	16	0.025
ameboidal type cell migration	GO:0001667	128	0.025
response to extracellular stimulus	GO:0009991	127	0.025
sequestering of metal ion	GO:0051238	19	0.025
establishment of organelle localization	GO:0051656	122	0.025
developmental growth involved in morphogenesis	GO:0060560	138	0.025
positive regulation of cell activation	GO:0050867	158	0.025
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.025
regulation of nfat protein import into nucleus	GO:0051532	4	0.025	Fly
regulation of protein catabolic process	GO:0042176	108	0.025
regulation of cell cycle	GO:0051726	281	0.024
positive regulation of cytokine production	GO:0001819	174	0.024
protein secretion	GO:0009306	111	0.024
single organism nuclear import	GO:1902593	95	0.024	Fly
wound healing	GO:0042060	157	0.024
regulation of wnt signaling pathway	GO:0030111	123	0.024
fatty acid metabolic process	GO:0006631	121	0.024
regulation of muscle tissue development	GO:1901861	97	0.024
lipid localization	GO:0010876	126	0.024
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.024
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.024
monosaccharide metabolic process	GO:0005996	106	0.024
cellular response to insulin stimulus	GO:0032869	78	0.024

Stim2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
organ system cancer	DOID:0050686	0.040
disease of cellular proliferation	DOID:14566	0.040
cancer	DOID:162	0.040
nervous system disease	DOID:863	0.033
disease of anatomical entity	DOID:7	0.033
musculoskeletal system disease	DOID:17	0.029

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