IMP: Integrative Multi-species Prediction

Mus musculus

201 known processes

Tal1

T-cell acute lymphocytic leukemia 1

(Aliases: tal-1,Scl,bHLHa17,SCL/tal-1)

Ensembl: ENSMUSG00000028717
Entrez: 21349
UniProtKB: Q3TZH7
UniProtKB: P22091

Process Predictions
Disease Predictions

Tal1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of erythrocyte differentiation	GO:0045646	23	0.994
erythrocyte differentiation	GO:0030218	88	0.989
myeloid cell differentiation	GO:0030099	233	0.983
histone acetylation	GO:0016573	41	0.979	Mouse
cell fate specification	GO:0001708	72	0.973	Mouse
covalent chromatin modification	GO:0016569	163	0.968	Mouse
negative regulation of myeloid cell differentiation	GO:0045638	38	0.933	Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.927	Mouse
spinal cord development	GO:0021510	81	0.925
gastrulation	GO:0007369	116	0.921
cell differentiation in spinal cord	GO:0021515	53	0.916
myeloid cell homeostasis	GO:0002262	114	0.912
eosinophil differentiation	GO:0030222	1	0.898
histone modification	GO:0016570	159	0.895	Mouse
internal protein amino acid acetylation	GO:0006475	42	0.893	Mouse
aortic valve morphogenesis	GO:0003180	4	0.891	Mouse
ventral spinal cord interneuron differentiation	GO:0021514	16	0.882
regulation of cellular amino acid metabolic process	GO:0006521	5	0.874
regionalization	GO:0003002	337	0.865	Mouse
central nervous system neuron differentiation	GO:0021953	162	0.831
protein acylation	GO:0043543	64	0.824	Mouse
peptidyl lysine modification	GO:0018205	77	0.810	Mouse
chromatin modification	GO:0016568	187	0.810	Mouse
head morphogenesis	GO:0060323	34	0.793	Mouse
sensory organ morphogenesis	GO:0090596	242	0.791	Mouse
embryonic placenta development	GO:0001892	98	0.779	Mouse
cardiac chamber development	GO:0003205	108	0.760	Mouse
cell fate commitment	GO:0045165	210	0.733
striated muscle tissue development	GO:0014706	293	0.732	Mouse
ventral spinal cord development	GO:0021517	48	0.724
cardiac ventricle development	GO:0003231	83	0.723	Mouse
somatic stem cell maintenance	GO:0035019	47	0.719
digestive tract development	GO:0048565	190	0.718
primitive hemopoiesis	GO:0060215	7	0.707
spinal cord association neuron differentiation	GO:0021527	14	0.702
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.697
heart morphogenesis	GO:0003007	178	0.695	Zebrafish Mouse
regulation of myeloid cell differentiation	GO:0045637	96	0.694
muscle tissue development	GO:0060537	308	0.677	Mouse
epithelial tube formation	GO:0072175	130	0.671	Mouse
stem cell differentiation	GO:0048863	268	0.669
neural tube closure	GO:0001843	90	0.664	Mouse
morphogenesis of embryonic epithelium	GO:0016331	159	0.662	Mouse
regulation of chromatin modification	GO:1903308	57	0.643	Mouse
homeostasis of number of cells	GO:0048872	210	0.636
amine metabolic process	GO:0009308	45	0.635
regulation of histone h3 k4 methylation	GO:0051569	12	0.627
wnt signaling pathway	GO:0016055	188	0.625
regulation of cell activation	GO:0050865	289	0.614
cardiac chamber morphogenesis	GO:0003206	93	0.614	Mouse
cardiac septum development	GO:0003279	59	0.610
tube formation	GO:0035148	140	0.609	Mouse
stem cell maintenance	GO:0019827	130	0.609
fat cell differentiation	GO:0045444	160	0.607
bmp signaling pathway	GO:0030509	93	0.603	Mouse
cell adhesion	GO:0007155	329	0.599
megakaryocyte differentiation	GO:0030219	26	0.591
response to molecule of bacterial origin	GO:0002237	143	0.585
neural tube development	GO:0021915	160	0.575	Mouse
gland development	GO:0048732	330	0.566	Zebrafish Mouse
regulation of dna binding	GO:0051101	39	0.562	Mouse
regulation of homeostatic process	GO:0032844	182	0.561
hematopoietic progenitor cell differentiation	GO:0002244	143	0.526
regulation of muscle tissue development	GO:1901861	97	0.523	Mouse
positive regulation of stem cell differentiation	GO:2000738	23	0.519	Mouse
regulation of neuron differentiation	GO:0045664	281	0.518	Mouse
epidermis development	GO:0008544	187	0.511	Mouse
inner ear morphogenesis	GO:0042472	101	0.510	Mouse
cytokine production	GO:0001816	319	0.502	Mouse
cardiac muscle tissue development	GO:0048738	130	0.492	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.485
myeloid leukocyte differentiation	GO:0002573	119	0.483
developmental maturation	GO:0021700	193	0.478
gonad morphogenesis	GO:0035262	1	0.474
peptidyl amino acid modification	GO:0018193	336	0.467	Mouse
hindbrain development	GO:0030902	128	0.462	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.458
cardiac septum morphogenesis	GO:0060411	46	0.453
regulation of cellular ketone metabolic process	GO:0010565	66	0.447
muscle cell differentiation	GO:0042692	261	0.445
regulation of peptidyl lysine acetylation	GO:2000756	22	0.441	Mouse
ventricular septum development	GO:0003281	42	0.437
chromatin organization	GO:0006325	206	0.435	Human Mouse
septum primum development	GO:0003284	4	0.434
axon guidance	GO:0007411	141	0.431	Mouse
digestive tract morphogenesis	GO:0048546	147	0.425
histone methylation	GO:0016571	71	0.425
transdifferentiation	GO:0060290	1	0.424	Mouse
regulation of stem cell differentiation	GO:2000736	50	0.421
neural tube formation	GO:0001841	108	0.420	Mouse
regulation of cytokine production	GO:0001817	266	0.407	Mouse
organ growth	GO:0035265	117	0.404
cellular response to thyroid hormone stimulus	GO:0097067	1	0.400
embryonic organ morphogenesis	GO:0048562	276	0.398	Mouse
cardiocyte differentiation	GO:0035051	87	0.394	Mouse
neuron projection guidance	GO:0097485	141	0.391	Mouse
regulation of binding	GO:0051098	111	0.390	Mouse
gonad development	GO:0008406	141	0.385
t helper 2 cell differentiation	GO:0045064	12	0.383
negative regulation of immune system process	GO:0002683	209	0.379	Mouse
primary neural tube formation	GO:0014020	95	0.379	Mouse
response to lipopolysaccharide	GO:0032496	128	0.377
cellular ketone metabolic process	GO:0042180	84	0.370
digestive system development	GO:0055123	200	0.369
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.359
kidney development	GO:0001822	213	0.357
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.356	Mouse
mesenchyme development	GO:0060485	152	0.352	Zebrafish Mouse
response to bmp	GO:0071772	14	0.351	Mouse
stem cell development	GO:0048864	219	0.347
formation of primary germ layer	GO:0001704	77	0.347
heart valve development	GO:0003170	23	0.344	Mouse
enteroendocrine cell differentiation	GO:0035883	16	0.342	Mouse
renal system development	GO:0072001	225	0.340
liver development	GO:0001889	66	0.339
development of primary sexual characteristics	GO:0045137	143	0.333
cellular response to growth factor stimulus	GO:0071363	197	0.324	Mouse
regulation of neuron projection development	GO:0010975	169	0.322	Mouse
angiogenesis	GO:0001525	201	0.321
metencephalon development	GO:0022037	89	0.312	Mouse
ear development	GO:0043583	200	0.309	Mouse
negative regulation of ossification	GO:0030279	49	0.308	Mouse
skin development	GO:0043588	220	0.307	Mouse
embryonic epithelial tube formation	GO:0001838	130	0.307	Mouse
mast cell differentiation	GO:0060374	5	0.305
determination of heart left right asymmetry	GO:0061371	48	0.299	Mouse
cell differentiation in hindbrain	GO:0021533	24	0.297
body morphogenesis	GO:0010171	45	0.296	Mouse
regulation of cardiac muscle tissue development	GO:0055024	31	0.296
positive regulation of nervous system development	GO:0051962	221	0.296	Mouse
regulation of histone modification	GO:0031056	56	0.295	Mouse
dendrite development	GO:0016358	115	0.294	Mouse
axonogenesis	GO:0007409	274	0.294	Mouse
neuron migration	GO:0001764	122	0.293	Mouse
t cell differentiation	GO:0030217	174	0.292
cell proliferation involved in outflow tract morphogenesis	GO:0061325	4	0.291	Mouse
wound healing	GO:0042060	157	0.290
lymphocyte differentiation	GO:0030098	242	0.290	Mouse
gene looping	GO:0090202	2	0.289
cardiac atrium development	GO:0003230	24	0.286
regulation of cardiac muscle cell proliferation	GO:0060043	23	0.278
mitral valve morphogenesis	GO:0003183	4	0.276	Mouse
camera type eye development	GO:0043010	266	0.275	Mouse
regulation of protein acetylation	GO:1901983	22	0.273	Mouse
aortic valve development	GO:0003176	5	0.272	Mouse
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.272
positive regulation of protein phosphorylation	GO:0001934	242	0.268
cardiac muscle cell differentiation	GO:0055007	69	0.267
regulation of organ growth	GO:0046620	61	0.261
placenta development	GO:0001890	140	0.260	Mouse
positive regulation of cell adhesion	GO:0045785	80	0.259
hemangioblast cell differentiation	GO:0060217	1	0.257
phenol containing compound biosynthetic process	GO:0046189	21	0.255	Mouse
hemostasis	GO:0007599	78	0.254
alpha beta t cell activation involved in immune response	GO:0002287	31	0.254
cell fate determination	GO:0001709	32	0.252	Mouse
atrioventricular valve morphogenesis	GO:0003181	13	0.247	Mouse
regulation of histone acetylation	GO:0035065	19	0.247	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.243
granulocyte differentiation	GO:0030851	17	0.243	Human
positive regulation of homeostatic process	GO:0032846	64	0.241
regulation of cardiac muscle tissue growth	GO:0055021	26	0.239
tendon formation	GO:0035992	4	0.237	Mouse
heart growth	GO:0060419	45	0.235
peptidyl lysine acetylation	GO:0018394	45	0.234	Mouse
somatic cell dna recombination	GO:0016444	51	0.231
erythrocyte maturation	GO:0043249	6	0.228
regulation of cell cycle	GO:0051726	281	0.221	Human Mouse
cellular response to follicle stimulating hormone stimulus	GO:0071372	1	0.220
regulation of organ morphogenesis	GO:2000027	144	0.218	Mouse
ureteric bud development	GO:0001657	94	0.217
regulation of chromosome organization	GO:0033044	83	0.217	Human Mouse
embryonic skeletal system morphogenesis	GO:0048704	91	0.214	Mouse
nephron epithelium morphogenesis	GO:0072088	68	0.212
clara cell differentiation	GO:0060486	4	0.212
regulation of neuron apoptotic process	GO:0043523	122	0.211
pancreatic pp cell fate commitment	GO:0003329	2	0.210	Mouse
definitive hemopoiesis	GO:0060216	20	0.209
regulation of chromatin organization	GO:1902275	57	0.209	Human Mouse
somatic diversification of immune receptors	GO:0002200	53	0.209
central nervous system neuron development	GO:0021954	67	0.208	Mouse
cardiac atrium morphogenesis	GO:0003209	23	0.206
regulation of cd4 positive alpha beta t cell activation	GO:2000514	24	0.205
muscle system process	GO:0003012	141	0.205
regulation of protein complex assembly	GO:0043254	83	0.205	Human
peptidyl tyrosine phosphorylation	GO:0018108	143	0.203
negative regulation of molecular function	GO:0044092	258	0.202	Mouse
regulation of ossification	GO:0030278	112	0.202	Mouse
coagulation	GO:0050817	78	0.199
retina morphogenesis in camera type eye	GO:0060042	45	0.198	Mouse
endodermal cell fate determination	GO:0007493	2	0.197
negative regulation of binding	GO:0051100	39	0.195	Mouse
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.195	Mouse
mesonephros development	GO:0001823	97	0.194
muscle cell development	GO:0055001	133	0.194
nephron epithelium development	GO:0072009	92	0.192
single organismal cell cell adhesion	GO:0016337	131	0.189
multicellular organismal homeostasis	GO:0048871	164	0.189	Mouse
lung development	GO:0030324	164	0.189
gastrulation with mouth forming second	GO:0001702	29	0.189
positive regulation of myeloid cell differentiation	GO:0045639	43	0.188
hematopoietic stem cell differentiation	GO:0060218	8	0.188
establishment or maintenance of cell polarity	GO:0007163	86	0.188	Mouse
response to retinoic acid	GO:0032526	56	0.187
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.185
regulation of heart growth	GO:0060420	31	0.184
urogenital system development	GO:0001655	261	0.183
pancreatic a cell differentiation	GO:0003310	7	0.182	Mouse
definitive erythrocyte differentiation	GO:0060318	7	0.182
epithelial tube morphogenesis	GO:0060562	303	0.182	Mouse
blood coagulation	GO:0007596	76	0.181
sympathetic nervous system development	GO:0048485	22	0.181	Mouse
negative regulation of leukocyte differentiation	GO:1902106	51	0.180
nephric duct formation	GO:0072179	4	0.180
cell type specific apoptotic process	GO:0097285	268	0.180	Mouse
forebrain neuron fate commitment	GO:0021877	13	0.179
atrial septum primum morphogenesis	GO:0003289	3	0.179
negative regulation of protein metabolic process	GO:0051248	282	0.178	Mouse
platelet formation	GO:0030220	12	0.178
endoderm development	GO:0007492	45	0.177
histone h3 acetylation	GO:0043966	14	0.177
ureteric bud morphogenesis	GO:0060675	62	0.176
regulation of t cell activation	GO:0050863	170	0.176
t cell activation	GO:0042110	289	0.176
muscle adaptation	GO:0043500	39	0.175
negative regulation of fat cell differentiation	GO:0045599	36	0.175
hepaticobiliary system development	GO:0061008	67	0.175
regulation of histone h3 k27 methylation	GO:0061085	6	0.174
dna metabolic process	GO:0006259	303	0.174
wnt signaling pathway involved in kidney development	GO:0061289	2	0.174
connective tissue development	GO:0061448	179	0.174	Mouse
histone lysine methylation	GO:0034968	50	0.173
cellular amine metabolic process	GO:0044106	44	0.169
glial cell differentiation	GO:0010001	131	0.168
regulation of cell projection organization	GO:0031344	206	0.168	Mouse
neural tube patterning	GO:0021532	43	0.167
dna recombination	GO:0006310	92	0.165
heart valve formation	GO:0003188	10	0.165	Mouse
forebrain development	GO:0030900	302	0.164	Mouse
bone mineralization	GO:0030282	54	0.164
regulation of neural precursor cell proliferation	GO:2000177	70	0.163
ear morphogenesis	GO:0042471	118	0.163	Mouse
neuron fate specification	GO:0048665	30	0.163	Mouse
positive regulation of striated muscle tissue development	GO:0045844	31	0.162
cell maturation	GO:0048469	127	0.161
autonomic nervous system development	GO:0048483	43	0.161	Mouse
positive regulation of cell development	GO:0010720	237	0.160	Mouse
regulation of organelle organization	GO:0033043	289	0.159	Human Mouse
cardiac muscle tissue morphogenesis	GO:0055008	44	0.158	Mouse
neuron apoptotic process	GO:0051402	142	0.157
single organism cell adhesion	GO:0098602	156	0.157
face morphogenesis	GO:0060325	29	0.156	Mouse
response to thyroid hormone	GO:0097066	2	0.155
regulation of definitive erythrocyte differentiation	GO:0010724	3	0.154
negative regulation of cell proliferation	GO:0008285	296	0.154	Mouse
internal peptidyl lysine acetylation	GO:0018393	42	0.154	Mouse
metanephros development	GO:0001656	79	0.154
odontogenesis of dentin containing tooth	GO:0042475	66	0.153	Mouse
production of molecular mediator of immune response	GO:0002440	103	0.153
anatomical structure homeostasis	GO:0060249	145	0.151	Mouse
neuroepithelial cell differentiation	GO:0060563	37	0.147
cardiac muscle tissue growth	GO:0055017	37	0.147
mitral valve development	GO:0003174	4	0.147	Mouse
epithelial cell fate commitment	GO:0072148	13	0.146	Mouse
regulation of t cell differentiation	GO:0045580	83	0.146
epithelial cell development	GO:0002064	159	0.145	Mouse
striated muscle cell development	GO:0055002	125	0.144
histone h3 k4 methylation	GO:0051568	23	0.144
striated muscle adaptation	GO:0014888	26	0.143
appendage morphogenesis	GO:0035107	149	0.142	Mouse
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.141
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.141
negative regulation of myeloid leukocyte differentiation	GO:0002762	20	0.140
mesoderm development	GO:0007498	100	0.140
spinal cord motor neuron differentiation	GO:0021522	35	0.139
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.139
negative regulation of cytokine production	GO:0001818	84	0.139	Mouse
cardiac right ventricle formation	GO:0003219	3	0.139	Mouse
mrna transcription from rna polymerase ii promoter	GO:0042789	4	0.139
regulation of anterior head development	GO:2000742	2	0.138
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.137
regulation of embryonic development	GO:0045995	71	0.137	Mouse
response to fibroblast growth factor	GO:0071774	47	0.137
response to transforming growth factor beta	GO:0071559	88	0.137	Mouse
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	51	0.137
neuroblast differentiation	GO:0014016	2	0.135
alpha beta t cell differentiation	GO:0046632	69	0.134
leukocyte differentiation	GO:0002521	342	0.134
regulation of cardioblast differentiation	GO:0051890	3	0.134
mitotic cell cycle	GO:0000278	195	0.134	Human Mouse
striated muscle cell proliferation	GO:0014855	39	0.133
stem cell fate specification	GO:0048866	3	0.129
immunoglobulin production	GO:0002377	73	0.128
t cell differentiation involved in immune response	GO:0002292	30	0.127
negative regulation of cell development	GO:0010721	169	0.127
regulation of oxidative phosphorylation uncoupler activity	GO:2000275	3	0.126	Mouse
immune effector process	GO:0002252	321	0.126
endodermal cell fate commitment	GO:0001711	12	0.124
negative regulation of chromatin modification	GO:1903309	19	0.124	Mouse
positive regulation of keratinocyte proliferation	GO:0010838	4	0.122	Mouse
regulation of megakaryocyte differentiation	GO:0045652	7	0.122
chemotaxis	GO:0006935	247	0.121	Mouse
tissue homeostasis	GO:0001894	115	0.120	Mouse
embryonic heart tube development	GO:0035050	65	0.118	Zebrafish Mouse
commitment of neuronal cell to specific neuron type in forebrain	GO:0021902	7	0.118
positive regulation of lymphocyte activation	GO:0051251	140	0.117
t helper cell differentiation	GO:0042093	28	0.117
macrophage differentiation	GO:0030225	20	0.117
chondrocyte differentiation	GO:0002062	72	0.116	Mouse
atrial septum morphogenesis	GO:0060413	11	0.116
embryonic digestive tract development	GO:0048566	27	0.115
embryonic digit morphogenesis	GO:0042733	56	0.114	Mouse
negative regulation of oxidative phosphorylation uncoupler activity	GO:2000276	2	0.114	Mouse
thymus development	GO:0048538	41	0.114	Mouse
glandular epithelial cell differentiation	GO:0002067	38	0.114	Mouse
regulation of fat cell differentiation	GO:0045598	81	0.114
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.113
anatomical structure maturation	GO:0071695	49	0.113
diencephalon development	GO:0021536	63	0.112	Mouse
biomineral tissue development	GO:0031214	64	0.112
endocardial cushion to mesenchymal transition involved in heart valve formation	GO:0003199	4	0.112	Mouse
regulation of bmp signaling pathway	GO:0030510	60	0.112
mesonephric epithelium development	GO:0072163	94	0.111
t cell differentiation in thymus	GO:0033077	77	0.110
regulation of angiogenesis	GO:0045765	81	0.110
heart valve morphogenesis	GO:0003179	21	0.109	Mouse
regulation of lymphocyte differentiation	GO:0045619	107	0.109
endocardial cushion development	GO:0003197	26	0.109	Mouse
negative regulation of chromosome organization	GO:2001251	30	0.108	Mouse
neuron death	GO:0070997	154	0.108
positive regulation of cardiac muscle tissue growth	GO:0055023	15	0.108
nephron tubule development	GO:0072080	84	0.108
forebrain generation of neurons	GO:0021872	63	0.108
regulation of auditory receptor cell differentiation	GO:0045607	4	0.107	Mouse
renal tubule morphogenesis	GO:0061333	72	0.107
embryonic limb morphogenesis	GO:0030326	126	0.107	Mouse
lymphocyte activation involved in immune response	GO:0002285	93	0.107
tongue development	GO:0043586	18	0.106	Mouse
nephron morphogenesis	GO:0072028	69	0.106
cardiac neural crest cell migration involved in outflow tract morphogenesis	GO:0003253	3	0.106	Mouse
positive regulation of neuron differentiation	GO:0045666	141	0.106	Mouse
regulation of hematopoietic progenitor cell differentiation	GO:1901532	18	0.105
lens development in camera type eye	GO:0002088	62	0.105
ventricular cardiac muscle tissue development	GO:0003229	38	0.105	Mouse
response to oxygen radical	GO:0000305	16	0.105
inflammatory response	GO:0006954	244	0.105
auditory receptor cell fate determination	GO:0042668	3	0.105	Mouse
platelet morphogenesis	GO:0036344	13	0.104
multi multicellular organism process	GO:0044706	109	0.104
pituitary gland development	GO:0021983	38	0.104
cellular homeostasis	GO:0019725	240	0.103
protein alkylation	GO:0008213	81	0.101
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.101
muscle cell proliferation	GO:0033002	52	0.100
regulation of ion transport	GO:0043269	215	0.100	Mouse
positive regulation of protein modification process	GO:0031401	299	0.100
negative regulation of type b pancreatic cell apoptotic process	GO:2000675	3	0.099	Mouse
positive regulation of inner ear receptor cell differentiation	GO:2000982	1	0.099	Mouse
response to growth factor	GO:0070848	198	0.099	Mouse
homotypic cell cell adhesion	GO:0034109	28	0.099
positive regulation of megakaryocyte differentiation	GO:0045654	4	0.099
spermatogenesis	GO:0007283	284	0.098
regulation of wnt signaling pathway	GO:0030111	123	0.098
regulation of neuron death	GO:1901214	134	0.098
positive regulation of ureteric bud formation	GO:0072107	3	0.098
somitogenesis	GO:0001756	69	0.098	Mouse
positive regulation of cell death	GO:0010942	224	0.097	Mouse
skeletal muscle fiber development	GO:0048741	58	0.097
sclerotome development	GO:0061056	4	0.096	Mouse
segmentation	GO:0035282	93	0.096	Mouse
cd4 positive alpha beta t cell activation	GO:0035710	45	0.096
tendon cell differentiation	GO:0035990	4	0.095	Mouse
positive regulation of cardiac muscle cell proliferation	GO:0060045	15	0.095
response to organonitrogen compound	GO:0010243	246	0.095
endocrine pancreas development	GO:0031018	29	0.094	Mouse
cardiac muscle cell proliferation	GO:0060038	31	0.094
nephron development	GO:0072006	109	0.094
protein methylation	GO:0006479	81	0.093
locomotory behavior	GO:0007626	195	0.092
ossification	GO:0001503	216	0.092	Mouse
phospholipid metabolic process	GO:0006644	87	0.092
embryonic digestive tract morphogenesis	GO:0048557	17	0.091
response to estrogen	GO:0043627	24	0.090
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:2000764	1	0.090	Mouse
endoderm formation	GO:0001706	20	0.090
regulation of cd4 positive alpha beta t cell differentiation	GO:0043370	21	0.089
mesonephric tubule development	GO:0072164	94	0.089
inorganic ion transmembrane transport	GO:0098660	234	0.089
pro t cell differentiation	GO:0002572	3	0.088
embryonic heart tube morphogenesis	GO:0003143	51	0.088	Mouse
canonical wnt signaling pathway	GO:0060070	130	0.087
face development	GO:0060324	38	0.087	Mouse
cellular response to gonadotropin stimulus	GO:0071371	4	0.087
embryonic appendage morphogenesis	GO:0035113	126	0.087	Mouse
posttranscriptional regulation of gene expression	GO:0010608	155	0.086
cellular response to oxidative stress	GO:0034599	76	0.086
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.086	Mouse
regulation of histone methylation	GO:0031060	30	0.086
mesenchyme morphogenesis	GO:0072132	32	0.086	Mouse
negative regulation of macrophage differentiation	GO:0045650	4	0.085
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.085
semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:0071527	1	0.085	Mouse
renal tubule development	GO:0061326	87	0.085
multi organism behavior	GO:0051705	62	0.084	Mouse
bone development	GO:0060348	120	0.084	Mouse
male sex differentiation	GO:0046661	109	0.084
forelimb morphogenesis	GO:0035136	40	0.083	Mouse
coronary artery morphogenesis	GO:0060982	6	0.083	Mouse
smad protein signal transduction	GO:0060395	21	0.083
organ regeneration	GO:0031100	2	0.083
positive regulation of t cell differentiation	GO:0045582	52	0.082
endodermal cell fate specification	GO:0001714	4	0.082
nephron tubule morphogenesis	GO:0072078	68	0.082
positive regulation of transcription regulatory region dna binding	GO:2000679	1	0.082
mesenchymal cell proliferation	GO:0010463	44	0.082	Mouse
regulation of interleukin 2 production	GO:0032663	28	0.081
interferon gamma production	GO:0032609	67	0.081
regulation of lymphocyte activation	GO:0051249	240	0.081
mesonephric tubule morphogenesis	GO:0072171	63	0.080
positive regulation of cell activation	GO:0050867	158	0.080
astrocyte fate commitment	GO:0060018	4	0.080
telencephalon development	GO:0021537	186	0.079	Mouse
forebrain neuron differentiation	GO:0021879	52	0.078
mesoderm formation	GO:0001707	62	0.078
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.078	Mouse
pancreas development	GO:0031016	57	0.078	Mouse
atrial septum development	GO:0003283	12	0.078
negative regulation of erythrocyte differentiation	GO:0045647	5	0.077
epithelial to mesenchymal transition	GO:0001837	47	0.077	Mouse
alpha beta t cell activation	GO:0046631	91	0.077
regulation of canonical wnt signaling pathway	GO:0060828	82	0.077
negative regulation of homeostatic process	GO:0032845	71	0.077
epidermal cell fate specification	GO:0009957	1	0.076
positive regulation of cardiac muscle tissue development	GO:0055025	19	0.076
regulation of chemokine production	GO:0032642	30	0.076
regulation of biomineral tissue development	GO:0070167	33	0.076
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.075	Mouse
positive regulation of mesonephros development	GO:0061213	20	0.075
cytokine secretion	GO:0050663	72	0.075
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.075
somatic diversification of immunoglobulins	GO:0016445	43	0.075
kidney morphogenesis	GO:0060993	83	0.075
regulation of mast cell differentiation	GO:0060375	3	0.075
positive regulation of binding	GO:0051099	49	0.074
cellular response to dna damage stimulus	GO:0006974	207	0.074
cell differentiation involved in kidney development	GO:0061005	33	0.074
male gamete generation	GO:0048232	285	0.074
catecholamine biosynthetic process	GO:0042423	11	0.073	Mouse
regulation of multi organism process	GO:0043900	111	0.073
otic vesicle development	GO:0071599	14	0.073
killing by host of symbiont cells	GO:0051873	11	0.073
notch signaling pathway	GO:0007219	71	0.073	Mouse
regulation of cardioblast proliferation	GO:0003264	9	0.072	Mouse
regulation of alpha beta t cell differentiation	GO:0046637	35	0.072
methylation	GO:0032259	134	0.072
limb development	GO:0060173	166	0.071	Mouse
limb morphogenesis	GO:0035108	149	0.071	Mouse
foregut morphogenesis	GO:0007440	12	0.071
norepinephrine biosynthetic process	GO:0042421	5	0.071	Mouse
regulation of cell proliferation involved in mesonephros development	GO:2000606	1	0.070
nephron tubule epithelial cell differentiation	GO:0072160	11	0.070
regulation of leukocyte differentiation	GO:1902105	159	0.070
transcription initiation from rna polymerase ii promoter	GO:0006367	8	0.070
visceral motor neuron differentiation	GO:0021524	3	0.070
cellular response to interleukin 4	GO:0071353	21	0.070
response to acid chemical	GO:0001101	111	0.070
cerebellar cortex development	GO:0021695	48	0.069	Mouse
protein secretion	GO:0009306	111	0.069
glial cell derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	GO:2000701	1	0.069
compound eye development	GO:0048749	1	0.069
regulation of engulfment of apoptotic cell	GO:1901074	2	0.068
bone morphogenesis	GO:0060349	78	0.068	Mouse
embryonic heart tube formation	GO:0003144	1	0.067	Mouse
monocyte differentiation	GO:0030224	9	0.067
positive regulation of organ growth	GO:0046622	29	0.067
neuroblast fate commitment	GO:0014017	1	0.066
ras protein signal transduction	GO:0007265	77	0.066
positive regulation of cardioblast differentiation	GO:0051891	3	0.066
immune response activating signal transduction	GO:0002757	116	0.066
appendage development	GO:0048736	166	0.065	Mouse
regulation of organ formation	GO:0003156	34	0.065	Mouse
retina development in camera type eye	GO:0060041	119	0.065	Mouse
cytokine biosynthetic process	GO:0042089	68	0.065
negative regulation of embryonic development	GO:0045992	22	0.064
negative regulation of interferon gamma production	GO:0032689	18	0.063
collagen fibril organization	GO:0030199	32	0.063	Mouse
cardiac muscle cell development	GO:0055013	39	0.063
cartilage development	GO:0051216	140	0.063	Mouse
rhythmic process	GO:0048511	174	0.063	Mouse
respiratory system development	GO:0060541	190	0.063
neural retina development	GO:0003407	41	0.062	Mouse

Tal1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
immune system disease	DOID:2914	0.661
disease of anatomical entity	DOID:7	0.661
hematopoietic system disease	DOID:74	0.661
blood coagulation disease	DOID:1247	0.557
blood platelet disease	DOID:2218	0.395
hemorrhagic disease	DOID:2213	0.395
inherited blood coagulation disease	DOID:2214	0.082

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