IMP: Integrative Multi-species Prediction

Mus musculus

91 known processes

Tmed2

transmembrane emp24 domain trafficking protein 2

(Aliases: p24beta1,Sid394,MGC102446,1110032D12Rik,1810020N21Rik,Rnp24)

Ensembl: ENSMUSG00000029390
Entrez: 56334
UniProtKB: A2RS53
UniProtKB: Q9R0Q3

Process Predictions
Disease Predictions

Tmed2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cytoplasmic transport	GO:0016482	234	0.178	Yeast Worm
membrane organization	GO:0061024	245	0.170	Human
regulation of protein localization	GO:0032880	231	0.087
leukocyte differentiation	GO:0002521	342	0.087
skeletal system development	GO:0001501	356	0.085
cellular amino acid metabolic process	GO:0006520	103	0.082
regulation of secretion by cell	GO:1903530	249	0.078
ribonucleotide metabolic process	GO:0009259	291	0.075	Human
peptidyl amino acid modification	GO:0018193	336	0.074
regulation of apoptotic signaling pathway	GO:2001233	197	0.065
apoptotic signaling pathway	GO:0097190	306	0.062
carbohydrate derivative biosynthetic process	GO:1901137	183	0.062
localization within membrane	GO:0051668	4	0.061
amine metabolic process	GO:0009308	45	0.061
purine ribonucleotide metabolic process	GO:0009150	290	0.059	Human
positive regulation of protein modification process	GO:0031401	299	0.057
intracellular protein transport	GO:0006886	204	0.055	Human
purine containing compound metabolic process	GO:0072521	311	0.055	Human
regulation of secretion	GO:0051046	274	0.055
positive regulation of secretion by cell	GO:1903532	114	0.054
cation homeostasis	GO:0055080	212	0.051
endomembrane system organization	GO:0010256	147	0.050	Human
carbohydrate metabolic process	GO:0005975	230	0.050
regulation of cellular amino acid metabolic process	GO:0006521	5	0.047
nitrogen compound transport	GO:0071705	271	0.045
regulation of cellular amine metabolic process	GO:0033238	20	0.045
cellular homeostasis	GO:0019725	240	0.045
cellular amine metabolic process	GO:0044106	44	0.044
er nucleus signaling pathway	GO:0006984	27	0.044
regulation of hormone levels	GO:0010817	211	0.042
intra golgi vesicle mediated transport	GO:0006891	1	0.042
establishment of vesicle localization	GO:0051650	81	0.040
multi multicellular organism process	GO:0044706	109	0.040
organelle localization	GO:0051640	179	0.040
response to topologically incorrect protein	GO:0035966	25	0.038
macromolecule glycosylation	GO:0043413	55	0.037
aromatic compound catabolic process	GO:0019439	286	0.037	Human
response to organonitrogen compound	GO:0010243	246	0.037
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.037	Human
regulation of establishment of protein localization	GO:0070201	181	0.036
oxidation reduction process	GO:0055114	342	0.036
organonitrogen compound biosynthetic process	GO:1901566	192	0.035
glycoprotein biosynthetic process	GO:0009101	89	0.035
endocytosis	GO:0006897	168	0.035
regulation of protein exit from endoplasmic reticulum	GO:0070861	1	0.035
establishment of organelle localization	GO:0051656	122	0.035
regulation of cellular component biogenesis	GO:0044087	181	0.034
response to organic cyclic compound	GO:0014070	198	0.034
response to unfolded protein	GO:0006986	21	0.034
male gamete generation	GO:0048232	285	0.034
positive regulation of growth	GO:0045927	104	0.033
regulation of leukocyte differentiation	GO:1902105	159	0.033
nucleoside catabolic process	GO:0009164	206	0.033	Human
positive regulation of protein phosphorylation	GO:0001934	242	0.033
regionalization	GO:0003002	337	0.033
lymphocyte differentiation	GO:0030098	242	0.032
nucleoside metabolic process	GO:0009116	246	0.032	Human
positive regulation of kinase activity	GO:0033674	155	0.030
regulation of cell activation	GO:0050865	289	0.030
gland development	GO:0048732	330	0.030
cellular response to antibiotic	GO:0071236	4	0.030
nucleoside phosphate catabolic process	GO:1901292	222	0.029	Human
inorganic ion transmembrane transport	GO:0098660	234	0.029
male sex differentiation	GO:0046661	109	0.029
regulation of intracellular transport	GO:0032386	159	0.029
posttranscriptional regulation of gene expression	GO:0010608	155	0.029
regulation of lymphocyte activation	GO:0051249	240	0.029
regulation of organelle organization	GO:0033043	289	0.029
cellular ketone metabolic process	GO:0042180	84	0.029
glycoprotein metabolic process	GO:0009100	116	0.028
extrinsic apoptotic signaling pathway	GO:0097191	126	0.028
purine nucleotide metabolic process	GO:0006163	302	0.028	Human
regulation of cell migration	GO:0030334	219	0.027
regulation of vesicle mediated transport	GO:0060627	139	0.027
camera type eye development	GO:0043010	266	0.026
circulatory system process	GO:0003013	197	0.026
immune effector process	GO:0002252	321	0.025
myeloid cell differentiation	GO:0030099	233	0.025
regulation of mapk cascade	GO:0043408	248	0.025
regulation of lymphocyte differentiation	GO:0045619	107	0.024
digestive tract development	GO:0048565	190	0.024
regulation of intracellular protein transport	GO:0033157	82	0.024
placenta development	GO:0001890	140	0.024
spermatogenesis	GO:0007283	284	0.023
regulation of kinase activity	GO:0043549	249	0.023
cell adhesion	GO:0007155	329	0.023
forebrain development	GO:0030900	302	0.023
muscle cell differentiation	GO:0042692	261	0.023
positive regulation of hydrolase activity	GO:0051345	148	0.023
nucleobase containing small molecule metabolic process	GO:0055086	352	0.023	Human
amide transport	GO:0042886	138	0.023
4 hydroxyproline metabolic process	GO:0019471	5	0.023
heterocycle catabolic process	GO:0046700	280	0.023	Human
cellular response to biotic stimulus	GO:0071216	92	0.022
purine ribonucleoside metabolic process	GO:0046128	241	0.022	Human
negative regulation of cellular component organization	GO:0051129	194	0.022
negative regulation of molecular function	GO:0044092	258	0.022	Human
regulation of protein kinase activity	GO:0045859	232	0.022
transmembrane transport	GO:0055085	412	0.022
regulation of protein transport	GO:0051223	163	0.022
positive regulation of protein kinase activity	GO:0045860	144	0.022
regulation of hydrolase activity	GO:0051336	246	0.022	Human
nucleotide metabolic process	GO:0009117	332	0.021	Human
regulation of cellular ketone metabolic process	GO:0010565	66	0.021
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.021
cation transport	GO:0006812	399	0.021
small gtpase mediated signal transduction	GO:0007264	97	0.021
cation transmembrane transport	GO:0098655	266	0.021
response to growth factor	GO:0070848	198	0.021
t cell activation	GO:0042110	289	0.020
lateral inhibition	GO:0046331	1	0.020
protein targeting	GO:0006605	143	0.020	Human
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.020
reactive oxygen species metabolic process	GO:0072593	84	0.020
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.020
nucleoside triphosphate metabolic process	GO:0009141	230	0.020	Human
regulation of cell motility	GO:2000145	236	0.020
cellular chemical homeostasis	GO:0055082	215	0.020
synaptic transmission	GO:0007268	329	0.020
ubiquitin dependent protein catabolic process	GO:0006511	129	0.020
ribonucleotide biosynthetic process	GO:0009260	59	0.019
proteasomal protein catabolic process	GO:0010498	98	0.019
inter male aggressive behavior	GO:0002121	3	0.019
cellular response to lipid	GO:0071396	145	0.019
chromatin organization	GO:0006325	206	0.019
maintenance of location	GO:0051235	89	0.019	Yeast
establishment of protein localization to organelle	GO:0072594	118	0.019
positive regulation of secretion	GO:0051047	130	0.019
bone development	GO:0060348	120	0.019
multicellular organismal signaling	GO:0035637	91	0.019
lymphocyte mediated immunity	GO:0002449	139	0.018
ribonucleotide catabolic process	GO:0009261	208	0.018	Human
positive regulation of cellular amine metabolic process	GO:0033240	5	0.018
regulation of er to golgi vesicle mediated transport	GO:0060628	4	0.018
skeletal system morphogenesis	GO:0048705	203	0.018
calcium ion homeostasis	GO:0055074	127	0.018
protein exit from endoplasmic reticulum	GO:0032527	1	0.018
epithelial cell proliferation	GO:0050673	174	0.018
ion transmembrane transport	GO:0034220	361	0.018
hormone secretion	GO:0046879	128	0.018
positive regulation of cell motility	GO:2000147	116	0.018
nucleocytoplasmic transport	GO:0006913	139	0.017
development of primary male sexual characteristics	GO:0046546	88	0.017
t cell differentiation	GO:0030217	174	0.017
cellular ion homeostasis	GO:0006873	165	0.017
golgi vesicle transport	GO:0048193	30	0.017	Yeast Worm
asymmetric stem cell division	GO:0098722	3	0.017
positive regulation of phospholipase activity	GO:0010518	3	0.017
muscle tissue development	GO:0060537	308	0.017
organophosphate biosynthetic process	GO:0090407	122	0.017
ribonucleoside metabolic process	GO:0009119	245	0.017	Human
regulation of actin filament based process	GO:0032970	99	0.017
histone modification	GO:0016570	159	0.017
positive regulation of programmed cell death	GO:0043068	218	0.017
spermatid development	GO:0007286	108	0.017
cellular lipid metabolic process	GO:0044255	323	0.017
cartilage development	GO:0051216	140	0.016
negative regulation of cell activation	GO:0050866	111	0.016
regulation of t cell differentiation	GO:0045580	83	0.016
connective tissue development	GO:0061448	179	0.016
regulation of vacuole organization	GO:0044088	4	0.016
cellular nitrogen compound catabolic process	GO:0044270	280	0.016	Human
positive regulation of mapk cascade	GO:0043410	170	0.016
response to oxygen radical	GO:0000305	16	0.016
intrinsic apoptotic signaling pathway	GO:0097193	132	0.016
glycosyl compound metabolic process	GO:1901657	246	0.016	Human
nucleoside phosphate metabolic process	GO:0006753	338	0.016	Human
endoplasmic reticulum unfolded protein response	GO:0030968	19	0.016
nucleoside phosphate biosynthetic process	GO:1901293	79	0.016
substantia nigra development	GO:0021762	2	0.016
male gonad development	GO:0008584	88	0.016
regulation of multi organism process	GO:0043900	111	0.016
multicellular organism growth	GO:0035264	161	0.016
actin polymerization or depolymerization	GO:0008154	54	0.016
compound eye development	GO:0048749	1	0.016
ribose phosphate metabolic process	GO:0019693	291	0.016	Human
macromolecule catabolic process	GO:0009057	281	0.015
multi organism reproductive behavior	GO:0044705	29	0.015
extracellular structure organization	GO:0043062	148	0.015
negative regulation of phosphorus metabolic process	GO:0010563	184	0.015	Human
regulation of protein complex assembly	GO:0043254	83	0.015
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.015
cytokine production	GO:0001816	319	0.015
positive regulation of cell death	GO:0010942	224	0.015
cellular response to cytokine stimulus	GO:0071345	189	0.015
protein maturation	GO:0051604	176	0.015
methylation	GO:0032259	134	0.015
regulation of cytokine production	GO:0001817	266	0.015
sensory perception	GO:0007600	245	0.015
action potential	GO:0001508	78	0.015
regulation of anatomical structure size	GO:0090066	178	0.015
cellular response to external stimulus	GO:0071496	88	0.015
establishment of protein localization to membrane	GO:0090150	54	0.015	Human
purine containing compound biosynthetic process	GO:0072522	70	0.015
epithelial cell development	GO:0002064	159	0.015
vacuole organization	GO:0007033	38	0.015
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.015	Human
striated muscle tissue development	GO:0014706	293	0.014
monocarboxylic acid metabolic process	GO:0032787	191	0.014
ras protein signal transduction	GO:0007265	77	0.014
peptide hormone secretion	GO:0030072	109	0.014
nucleotide biosynthetic process	GO:0009165	78	0.014
multi organism behavior	GO:0051705	62	0.014
b cell activation	GO:0042113	161	0.014
cellular response to growth factor stimulus	GO:0071363	197	0.014
lung development	GO:0030324	164	0.014
protein folding	GO:0006457	28	0.014
cellular response to lipopolysaccharide	GO:0071222	77	0.014
regulation of epithelial cell proliferation	GO:0050678	141	0.014
protein localization to membrane	GO:0072657	108	0.014	Human
divalent inorganic cation transport	GO:0072511	178	0.014
glucose metabolic process	GO:0006006	92	0.014
digestive system development	GO:0055123	200	0.014
regulation of t cell activation	GO:0050863	170	0.014
purine nucleoside metabolic process	GO:0042278	241	0.014	Human
myeloid leukocyte differentiation	GO:0002573	119	0.014
cellular metal ion homeostasis	GO:0006875	151	0.014
extracellular matrix organization	GO:0030198	147	0.014
anatomical structure homeostasis	GO:0060249	145	0.014
regulation of protein stability	GO:0031647	52	0.013
modification dependent protein catabolic process	GO:0019941	133	0.013
cellular protein complex assembly	GO:0043623	116	0.013
regulation of response to wounding	GO:1903034	189	0.013
mapk cascade	GO:0000165	281	0.013
receptor mediated endocytosis	GO:0006898	51	0.013
protein acylation	GO:0043543	64	0.013
golgi organization	GO:0007030	9	0.013	Human
chromatin modification	GO:0016568	187	0.013
spermatid differentiation	GO:0048515	115	0.013
peptide transport	GO:0015833	133	0.013
carbohydrate derivative catabolic process	GO:1901136	231	0.013	Human
response to molecule of bacterial origin	GO:0002237	143	0.013
mitotic cytokinesis	GO:0000281	4	0.013
response to lipopolysaccharide	GO:0032496	128	0.013
regulation of reproductive process	GO:2000241	66	0.013
wnt signaling pathway	GO:0016055	188	0.013
cell aging	GO:0007569	35	0.013
hexose metabolic process	GO:0019318	98	0.013
positive regulation of protein transport	GO:0051222	93	0.013
single organism cell adhesion	GO:0098602	156	0.013
blood circulation	GO:0008015	195	0.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.013
regulation of endocytosis	GO:0030100	69	0.013
innate immune response	GO:0045087	157	0.013
divalent inorganic cation homeostasis	GO:0072507	138	0.013
multicellular organismal homeostasis	GO:0048871	164	0.012
inflammatory response	GO:0006954	244	0.012
metal ion homeostasis	GO:0055065	189	0.012
metencephalon development	GO:0022037	89	0.012
vesicle localization	GO:0051648	86	0.012
organic hydroxy compound metabolic process	GO:1901615	203	0.012
dephosphorylation	GO:0016311	129	0.012
nucleotide catabolic process	GO:0009166	217	0.012	Human
purine nucleotide catabolic process	GO:0006195	211	0.012	Human
protein secretion	GO:0009306	111	0.012
regulation of membrane potential	GO:0042391	192	0.012
glucose homeostasis	GO:0042593	128	0.012
respiratory system development	GO:0060541	190	0.012
regulation of lamellipodium assembly	GO:0010591	3	0.012
cellular response to dna damage stimulus	GO:0006974	207	0.012
chromosome segregation	GO:0007059	48	0.012
gtp catabolic process	GO:0006184	143	0.012	Human
positive regulation of endocytosis	GO:0045807	42	0.012
negative regulation of cellular protein metabolic process	GO:0032269	247	0.012
morphogenesis of embryonic epithelium	GO:0016331	159	0.012
developmental maturation	GO:0021700	193	0.012
cellular response to extracellular stimulus	GO:0031668	81	0.012
leukocyte mediated immunity	GO:0002443	174	0.012
peptide secretion	GO:0002790	114	0.011
regulation of hormone secretion	GO:0046883	88	0.011
regulation of purine nucleotide metabolic process	GO:1900542	169	0.011	Human
carbohydrate homeostasis	GO:0033500	128	0.011
negative regulation of phosphate metabolic process	GO:0045936	184	0.011	Human
cellular response to nutrient levels	GO:0031669	64	0.011
limb development	GO:0060173	166	0.011
post mating behavior	GO:0045297	3	0.011
membrane lipid metabolic process	GO:0006643	53	0.011
positive regulation of transferase activity	GO:0051347	167	0.011
response to inorganic substance	GO:0010035	96	0.011
regulation of peptide hormone secretion	GO:0090276	75	0.011
positive regulation of apoptotic process	GO:0043065	217	0.011
midgut development	GO:0007494	4	0.011
positive regulation of peptide hormone secretion	GO:0090277	31	0.011
ossification	GO:0001503	216	0.011
nucleoside triphosphate catabolic process	GO:0009143	205	0.011	Human
peptidyl lysine modification	GO:0018205	77	0.011
rna processing	GO:0006396	105	0.011
embryonic organ morphogenesis	GO:0048562	276	0.011
neuron death	GO:0070997	154	0.011
negative regulation of immune system process	GO:0002683	209	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.011	Human
blood vessel morphogenesis	GO:0048514	285	0.011
regulation of purine nucleotide catabolic process	GO:0033121	122	0.011	Human
monosaccharide metabolic process	GO:0005996	106	0.010
regulation of actin cytoskeleton organization	GO:0032956	84	0.010
cellular response to topologically incorrect protein	GO:0035967	25	0.010
guanosine containing compound catabolic process	GO:1901069	144	0.010	Human
tissue homeostasis	GO:0001894	115	0.010
gtp metabolic process	GO:0046039	144	0.010	Human
positive regulation of organelle organization	GO:0010638	128	0.010
inorganic cation transmembrane transport	GO:0098662	207	0.010
maintenance of location in cell	GO:0051651	24	0.010	Yeast
peptidyl asparagine modification	GO:0018196	1	0.010
exocytosis	GO:0006887	121	0.010
glial cell differentiation	GO:0010001	131	0.010
sphingolipid metabolic process	GO:0006665	45	0.010
protein glycosylation	GO:0006486	55	0.010
copii coated vesicle budding	GO:0090114	2	0.010

Tmed2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
inherited metabolic disorder	DOID:655	0.030
disease of metabolism	DOID:0014667	0.030
bone disease	DOID:0080001	0.013
bone development disease	DOID:0080006	0.013
disease of anatomical entity	DOID:7	0.013
connective tissue disease	DOID:65	0.013
musculoskeletal system disease	DOID:17	0.013

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