IMP: Integrative Multi-species Prediction

Mus musculus

156 known processes

Trim24

tripartite motif-containing 24

(Aliases: AI447469,D430004I05Rik,Tif1a,A130082H20Rik,TIF1alpha,TIF1)

Entrez: 21848
Ensembl: ENSMUSG00000029833
UniProtKB: E9Q1U8
UniProtKB: Q64127
UniProtKB: Q3V0H4

Process Predictions
Disease Predictions

Trim24 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
histone h3 k9 dimethylation	GO:0036123	4	0.999
regulation of histone h3 k9 methylation	GO:0051570	8	0.884
dna hypermethylation	GO:0044026	3	0.842
regulation of dna methylation	GO:0044030	12	0.839
heterochromatin assembly	GO:0031507	2	0.832
histone h4 k20 trimethylation	GO:0034773	2	0.809
macromolecule methylation	GO:0043414	120	0.796	Mouse
heterochromatin organization	GO:0070828	4	0.776
positive regulation of histone h3 k9 methylation	GO:0051574	4	0.764
histone lysine methylation	GO:0034968	50	0.749
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.698
regulation of histone methylation	GO:0031060	30	0.689
protein alkylation	GO:0008213	81	0.688
histone h3 k9 methylation	GO:0051567	17	0.682
regulation of cellular ketone metabolic process	GO:0010565	66	0.652
dna alkylation	GO:0006305	43	0.646	Mouse
histone methylation	GO:0016571	71	0.639
regulation of transcription by chromatin organization	GO:0034401	0	0.631
cellular amino acid metabolic process	GO:0006520	103	0.611
dna modification	GO:0006304	50	0.605	Mouse
covalent chromatin modification	GO:0016569	163	0.588
regulation of chromosome organization	GO:0033044	83	0.576
amine metabolic process	GO:0009308	45	0.569
dna methylation	GO:0006306	43	0.542	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.533
olfactory learning	GO:0008355	2	0.502
peptidyl lysine trimethylation	GO:0018023	12	0.482
cellular ketone metabolic process	GO:0042180	84	0.477
positive regulation of cellular amine metabolic process	GO:0033240	5	0.475
chromatin organization	GO:0006325	206	0.458	Fly
histone h4 k20 methylation	GO:0034770	8	0.447
regulation of cellular amine metabolic process	GO:0033238	20	0.444
peptidyl lysine methylation	GO:0018022	29	0.441
histone modification	GO:0016570	159	0.440
positive regulation of histone methylation	GO:0031062	16	0.431
positive regulation of chromatin modification	GO:1903310	28	0.427
regulation of chromatin modification	GO:1903308	57	0.419
cellular amine metabolic process	GO:0044106	44	0.414
methylation	GO:0032259	134	0.401	Mouse
positive regulation of chromosome organization	GO:2001252	33	0.384
regulation of histone modification	GO:0031056	56	0.339
protein methylation	GO:0006479	81	0.323
telomere maintenance	GO:0000723	19	0.305
regulation of chromatin silencing	GO:0031935	2	0.269
positive regulation of histone modification	GO:0031058	28	0.263
dna packaging	GO:0006323	30	0.255
ras protein signal transduction	GO:0007265	77	0.249
chromatin modification	GO:0016568	187	0.235
peptidyl amino acid modification	GO:0018193	336	0.224
peptidyl lysine modification	GO:0018205	77	0.221
dna metabolic process	GO:0006259	303	0.217	Mouse
regulation of chromatin organization	GO:1902275	57	0.213
small gtpase mediated signal transduction	GO:0007264	97	0.210
anatomical structure homeostasis	GO:0060249	145	0.207
regulation of organelle organization	GO:0033043	289	0.189
positive regulation of protein modification process	GO:0031401	299	0.173
positive regulation of organelle organization	GO:0010638	128	0.160
positive regulation of cellular component biogenesis	GO:0044089	94	0.159
chromatin assembly	GO:0031497	13	0.148
negative regulation of intracellular signal transduction	GO:1902532	167	0.136
dna conformation change	GO:0071103	37	0.136
chromatin assembly or disassembly	GO:0006333	16	0.127
regulation of cellular component biogenesis	GO:0044087	181	0.111
regulation of ras protein signal transduction	GO:0046578	114	0.109
multicellular organism growth	GO:0035264	161	0.108
chromatin silencing	GO:0006342	15	0.106
negative regulation of chromosome organization	GO:2001251	30	0.105
negative regulation of organelle organization	GO:0010639	90	0.104
gene silencing	GO:0016458	38	0.102
dna dealkylation	GO:0035510	11	0.081	Mouse
negative regulation of ras protein signal transduction	GO:0046580	18	0.077
macromolecule catabolic process	GO:0009057	281	0.076
negative regulation of cellular component organization	GO:0051129	194	0.076
cognition	GO:0050890	149	0.076
positive regulation of growth	GO:0045927	104	0.075
intracellular receptor signaling pathway	GO:0030522	74	0.073
development of primary sexual characteristics	GO:0045137	143	0.067
negative regulation of gene expression epigenetic	GO:0045814	15	0.057
negative regulation of cellular protein metabolic process	GO:0032269	247	0.054
negative regulation of chromatin modification	GO:1903309	19	0.054
protein modification by small protein conjugation	GO:0032446	187	0.053
response to vitamin d	GO:0033280	3	0.053
peptidyl lysine dimethylation	GO:0018027	6	0.053
cellular response to dna damage stimulus	GO:0006974	207	0.051
developmental growth involved in morphogenesis	GO:0060560	138	0.050	Mouse
cellular response to lipid	GO:0071396	145	0.050
cellular protein catabolic process	GO:0044257	155	0.049
neuronal action potential	GO:0019228	54	0.048
mitotic cell cycle	GO:0000278	195	0.046
learning or memory	GO:0007611	148	0.044
response to radiation	GO:0009314	165	0.043
multicellular organismal signaling	GO:0035637	91	0.040
regulation of protein localization	GO:0032880	231	0.040
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.039
chromatin remodeling	GO:0006338	32	0.039
regulation of membrane potential	GO:0042391	192	0.039
protein localization to nucleus	GO:0034504	121	0.038
gonad development	GO:0008406	141	0.038
associative learning	GO:0008306	61	0.037
demethylation	GO:0070988	23	0.037	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.037
protein catabolic process	GO:0030163	221	0.036
microtubule cytoskeleton organization	GO:0000226	157	0.034
organelle fission	GO:0048285	170	0.034
translation	GO:0006412	93	0.034
embryonic placenta development	GO:0001892	98	0.033	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.032
homeostasis of number of cells	GO:0048872	210	0.031
action potential	GO:0001508	78	0.031
intracellular protein transport	GO:0006886	204	0.031
cytoplasmic transport	GO:0016482	234	0.031
protein import	GO:0017038	101	0.031
metal ion homeostasis	GO:0055065	189	0.031
transmission of nerve impulse	GO:0019226	76	0.030
protein autophosphorylation	GO:0046777	61	0.030
divalent inorganic cation homeostasis	GO:0072507	138	0.030
regulation of cytoplasmic transport	GO:1903649	112	0.029
regulation of cytokine production	GO:0001817	266	0.029
positive regulation of programmed cell death	GO:0043068	218	0.028
stem cell development	GO:0048864	219	0.028	Mouse
cell type specific apoptotic process	GO:0097285	268	0.028
protein modification by small protein conjugation or removal	GO:0070647	207	0.027
axonogenesis	GO:0007409	274	0.027	Fly
muscle cell differentiation	GO:0042692	261	0.027
striated muscle tissue development	GO:0014706	293	0.027
negative regulation of immune system process	GO:0002683	209	0.026
gland development	GO:0048732	330	0.026
nucleobase containing small molecule metabolic process	GO:0055086	352	0.026
sensory organ morphogenesis	GO:0090596	242	0.026
germ cell development	GO:0007281	185	0.025
camera type eye development	GO:0043010	266	0.025
response to extracellular stimulus	GO:0009991	127	0.025
ubiquitin dependent protein catabolic process	GO:0006511	129	0.025
changes to dna methylation involved in embryo development	GO:1901538	6	0.025	Mouse
positive regulation of apoptotic process	GO:0043065	217	0.025
aromatic compound catabolic process	GO:0019439	286	0.024
response to light stimulus	GO:0009416	135	0.024
nuclear import	GO:0051170	95	0.024
protein targeting	GO:0006605	143	0.024
maintenance of location	GO:0051235	89	0.024
regulation of intracellular transport	GO:0032386	159	0.023
microtubule based process	GO:0007017	236	0.023
regulation of cellular response to stress	GO:0080135	159	0.023
spermatogenesis	GO:0007283	284	0.023
ensheathment of neurons	GO:0007272	76	0.023
dna repair	GO:0006281	107	0.023
protein import into nucleus	GO:0006606	95	0.023
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.023
cellular chemical homeostasis	GO:0055082	215	0.023
cytokine production	GO:0001816	319	0.022
positive regulation of cell death	GO:0010942	224	0.022
regulation of protein transport	GO:0051223	163	0.022
meiotic cell cycle	GO:0051321	122	0.022
protein processing	GO:0016485	163	0.022
myeloid cell homeostasis	GO:0002262	114	0.022
nitrogen compound transport	GO:0071705	271	0.022
cellular response to external stimulus	GO:0071496	88	0.022
negative regulation of cellular amine metabolic process	GO:0033239	1	0.022
sensory perception	GO:0007600	245	0.022
regulation of neuron differentiation	GO:0045664	281	0.022
posttranscriptional regulation of gene expression	GO:0010608	155	0.022
mesenchyme development	GO:0060485	152	0.022	Mouse
calcium ion homeostasis	GO:0055074	127	0.021
cation homeostasis	GO:0055080	212	0.021
interspecies interaction between organisms	GO:0044419	83	0.021
regulation of response to alcohol	GO:1901419	2	0.021
myelination	GO:0042552	74	0.021
regulation of hormone levels	GO:0010817	211	0.020
signal transduction by p53 class mediator	GO:0072331	51	0.020
cell adhesion	GO:0007155	329	0.020
axon ensheathment	GO:0008366	76	0.020
forebrain development	GO:0030900	302	0.020
cellular response to organonitrogen compound	GO:0071417	145	0.020
female gamete generation	GO:0007292	74	0.020
negative regulation of protein modification process	GO:0031400	163	0.020
response to organonitrogen compound	GO:0010243	246	0.020
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.020
regulation of secretion by cell	GO:1903530	249	0.020
positive regulation of protein phosphorylation	GO:0001934	242	0.019
transmembrane transport	GO:0055085	412	0.019
cation transport	GO:0006812	399	0.019
cellular response to organic cyclic compound	GO:0071407	87	0.019
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.019
dna demethylation	GO:0080111	10	0.019	Mouse
nucleoside phosphate catabolic process	GO:1901292	222	0.019
genetic imprinting	GO:0071514	27	0.019	Mouse
purine nucleoside catabolic process	GO:0006152	205	0.019
protein maturation	GO:0051604	176	0.019
dna recombination	GO:0006310	92	0.019
regulation of hydrolase activity	GO:0051336	246	0.018
mitotic cell cycle process	GO:1903047	159	0.018
ion transmembrane transport	GO:0034220	361	0.018
cation transmembrane transport	GO:0098655	266	0.018
developmental maturation	GO:0021700	193	0.018
protein ubiquitination	GO:0016567	171	0.018
stem cell differentiation	GO:0048863	268	0.018	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.018
hematopoietic progenitor cell differentiation	GO:0002244	143	0.018
regulation of secretion	GO:0051046	274	0.018
compound eye development	GO:0048749	1	0.018
protein localization to organelle	GO:0033365	185	0.018
glucose homeostasis	GO:0042593	128	0.018
innate immune response	GO:0045087	157	0.018
placenta development	GO:0001890	140	0.017	Mouse
regulation of multi organism process	GO:0043900	111	0.017
ossification	GO:0001503	216	0.017
epithelial tube morphogenesis	GO:0060562	303	0.017
ribonucleoside catabolic process	GO:0042454	206	0.017
regulation of protein targeting	GO:1903533	61	0.017
regulation of system process	GO:0044057	200	0.017
regulation of homeostatic process	GO:0032844	182	0.017
regulation of binding	GO:0051098	111	0.017
regulation of response to dna damage stimulus	GO:2001020	34	0.017
regulation of lymphocyte activation	GO:0051249	240	0.017
immune effector process	GO:0002252	321	0.016
neuron projection guidance	GO:0097485	141	0.016	Fly
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.016
cellular homeostasis	GO:0019725	240	0.016
establishment of protein localization to organelle	GO:0072594	118	0.016
positive regulation of cholesterol homeostasis	GO:2000189	2	0.016
tube closure	GO:0060606	91	0.016
modification dependent protein catabolic process	GO:0019941	133	0.016
negative regulation of mitotic cell cycle	GO:0045930	58	0.016
muscle tissue development	GO:0060537	308	0.016
regulation of cell activation	GO:0050865	289	0.016
positive regulation of hydrolase activity	GO:0051345	148	0.016
carbohydrate derivative catabolic process	GO:1901136	231	0.016
skeletal muscle organ development	GO:0060538	163	0.016
appendage development	GO:0048736	166	0.016
regulation of purine nucleotide metabolic process	GO:1900542	169	0.016
myeloid cell differentiation	GO:0030099	233	0.016
dendrite development	GO:0016358	115	0.016	Fly
regulation of proteolysis	GO:0030162	164	0.016
protein oligomerization	GO:0051259	67	0.016
rho protein signal transduction	GO:0007266	32	0.016
nuclear transport	GO:0051169	139	0.015
lipid localization	GO:0010876	126	0.015
intrinsic apoptotic signaling pathway	GO:0097193	132	0.015
appendage morphogenesis	GO:0035107	149	0.015
regulation of nucleotide metabolic process	GO:0006140	169	0.015
t cell activation	GO:0042110	289	0.015
regulation of apoptotic signaling pathway	GO:2001233	197	0.015
organic cyclic compound catabolic process	GO:1901361	295	0.015
vitamin d receptor signaling pathway	GO:0070561	2	0.015
skeletal system development	GO:0001501	356	0.015
circulatory system process	GO:0003013	197	0.015
ribonucleotide catabolic process	GO:0009261	208	0.015
urogenital system development	GO:0001655	261	0.015
cellular lipid metabolic process	GO:0044255	323	0.015
inorganic ion transmembrane transport	GO:0098660	234	0.015
male gamete generation	GO:0048232	285	0.015
meiotic nuclear division	GO:0007126	115	0.015
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.014
embryonic organ morphogenesis	GO:0048562	276	0.014
purine ribonucleotide metabolic process	GO:0009150	290	0.014
nucleoside metabolic process	GO:0009116	246	0.014
organic acid biosynthetic process	GO:0016053	86	0.014
cellular macromolecule catabolic process	GO:0044265	206	0.014
limb morphogenesis	GO:0035108	149	0.014
regulation of leukocyte differentiation	GO:1902105	159	0.014
regulation of protein maturation	GO:1903317	96	0.014
glycosyl compound metabolic process	GO:1901657	246	0.014
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.014
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.014
divalent metal ion transport	GO:0070838	172	0.014
regulation of protein processing	GO:0070613	96	0.014
neuron death	GO:0070997	154	0.014
proteasomal protein catabolic process	GO:0010498	98	0.014
spermatid differentiation	GO:0048515	115	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.013
purine containing compound metabolic process	GO:0072521	311	0.013
mitotic nuclear division	GO:0007067	48	0.013
membrane organization	GO:0061024	245	0.013
amide transport	GO:0042886	138	0.013
nucleotide catabolic process	GO:0009166	217	0.013
leukocyte differentiation	GO:0002521	342	0.013
purine ribonucleoside catabolic process	GO:0046130	205	0.013
organophosphate biosynthetic process	GO:0090407	122	0.013
cellular response to acid chemical	GO:0071229	68	0.013
photoreceptor cell differentiation	GO:0046530	52	0.013
carboxylic acid biosynthetic process	GO:0046394	86	0.013
purine nucleotide metabolic process	GO:0006163	302	0.013
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.013
response to uv	GO:0009411	44	0.013
ribose phosphate metabolic process	GO:0019693	291	0.013
response to acid chemical	GO:0001101	111	0.013
cellular ion homeostasis	GO:0006873	165	0.013
limb development	GO:0060173	166	0.013
digestive tract development	GO:0048565	190	0.013
cellular response to peptide hormone stimulus	GO:0071375	92	0.013
purine ribonucleotide catabolic process	GO:0009154	208	0.013
regulation of mapk cascade	GO:0043408	248	0.013
negative regulation of molecular function	GO:0044092	258	0.013
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.012
post embryonic retina morphogenesis in camera type eye	GO:0060060	3	0.012
regulation of antimicrobial humoral response	GO:0002759	3	0.012
translational initiation	GO:0006413	24	0.012
ear development	GO:0043583	200	0.012
embryonic appendage morphogenesis	GO:0035113	126	0.012
kidney development	GO:0001822	213	0.012
response to vitamin a	GO:0033189	1	0.012
wnt signaling pathway	GO:0016055	188	0.012
cellular response to nutrient levels	GO:0031669	64	0.012
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.012
regulation of protein complex assembly	GO:0043254	83	0.012
meiotic cell cycle process	GO:1903046	77	0.012
negative regulation of cytokine production	GO:0001818	84	0.012
response to organic cyclic compound	GO:0014070	198	0.012
cellular nitrogen compound catabolic process	GO:0044270	280	0.012
regulation of cell projection organization	GO:0031344	206	0.012
negative regulation of dna replication	GO:0008156	4	0.012
nucleoside triphosphate catabolic process	GO:0009143	205	0.012
organic anion transport	GO:0015711	137	0.012
oxidation reduction process	GO:0055114	342	0.012
multi multicellular organism process	GO:0044706	109	0.012	Mouse
organonitrogen compound catabolic process	GO:1901565	264	0.012
inorganic cation transmembrane transport	GO:0098662	207	0.012
peptide transport	GO:0015833	133	0.012
regulation of protein localization to nucleus	GO:1900180	60	0.012
respiratory tube development	GO:0030323	167	0.012
monocarboxylic acid metabolic process	GO:0032787	191	0.012
nucleocytoplasmic transport	GO:0006913	139	0.012
carbohydrate metabolic process	GO:0005975	230	0.012
learning	GO:0007612	98	0.012
modulation by virus of host morphology or physiology	GO:0019048	3	0.012
chemotaxis	GO:0006935	247	0.011	Fly
negative regulation of multi organism process	GO:0043901	68	0.011
regulation of protein kinase activity	GO:0045859	232	0.011
skin development	GO:0043588	220	0.011
organophosphate catabolic process	GO:0046434	232	0.011
modification dependent macromolecule catabolic process	GO:0043632	133	0.011
negative regulation of cell cycle process	GO:0010948	69	0.011
response to molecule of bacterial origin	GO:0002237	143	0.011
positive regulation of translational initiation	GO:0045948	4	0.011
regulation of protein binding	GO:0043393	60	0.011
divalent inorganic cation transport	GO:0072511	178	0.011
cellular response to extracellular stimulus	GO:0031668	81	0.011
positive regulation of nervous system development	GO:0051962	221	0.011
eye photoreceptor cell differentiation	GO:0001754	41	0.011
negative regulation of phosphorus metabolic process	GO:0010563	184	0.011
inflammatory response	GO:0006954	244	0.011
fat soluble vitamin biosynthetic process	GO:0042362	4	0.011
regulation of defense response	GO:0031347	233	0.011
lateral inhibition	GO:0046331	1	0.011
regulation of translational initiation	GO:0006446	15	0.011
neural tube formation	GO:0001841	108	0.011
morphogenesis of a branching epithelium	GO:0061138	193	0.011
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.011
mapk cascade	GO:0000165	281	0.011
organelle localization	GO:0051640	179	0.011
response to nutrient levels	GO:0031667	109	0.011
circadian rhythm	GO:0007623	114	0.011
cellular response to gamma radiation	GO:0071480	4	0.011
apoptotic signaling pathway	GO:0097190	306	0.011
chemosensory behavior	GO:0007635	11	0.011
response to inorganic substance	GO:0010035	96	0.011
regulation of purine nucleotide catabolic process	GO:0033121	122	0.011
lipid biosynthetic process	GO:0008610	179	0.011
regulation of anatomical structure size	GO:0090066	178	0.011
regulation of translation	GO:0006417	71	0.011
digestive system development	GO:0055123	200	0.011
regulation of kinase activity	GO:0043549	249	0.011
negative regulation of protein metabolic process	GO:0051248	282	0.011
actin cytoskeleton organization	GO:0030036	220	0.011
chromosome segregation	GO:0007059	48	0.011
heart morphogenesis	GO:0003007	178	0.011
positive regulation of defense response	GO:0031349	124	0.011
regulation of cellular catabolic process	GO:0031329	242	0.011
regulation of neuron apoptotic process	GO:0043523	122	0.011
endomembrane system organization	GO:0010256	147	0.011
cellular response to vitamin	GO:0071295	2	0.011
response to peptide hormone	GO:0043434	127	0.011
regulation of nucleoside metabolic process	GO:0009118	130	0.010
neural tube development	GO:0021915	160	0.010
sensory perception of mechanical stimulus	GO:0050954	107	0.010
ribonucleotide metabolic process	GO:0009259	291	0.010
midgut development	GO:0007494	4	0.010
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.010
meiosis i	GO:0007127	60	0.010
peptide secretion	GO:0002790	114	0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.010
photoreceptor cell development	GO:0042461	40	0.010
engulfment of apoptotic cell	GO:0043652	3	0.010
positive regulation of transferase activity	GO:0051347	167	0.010
regulation of response to wounding	GO:1903034	189	0.010
embryonic limb morphogenesis	GO:0030326	126	0.010
cellularization	GO:0007349	1	0.010
cellular response to hormone stimulus	GO:0032870	150	0.010	Human
cellular protein complex assembly	GO:0043623	116	0.010
positive regulation of cytokine production	GO:0001819	174	0.010
organic hydroxy compound metabolic process	GO:1901615	203	0.010
microtubule cytoskeleton organization involved in mitosis	GO:1902850	4	0.010
hormone secretion	GO:0046879	128	0.010
leukocyte mediated immunity	GO:0002443	174	0.010
oocyte axis specification	GO:0007309	2	0.010
gastrulation	GO:0007369	116	0.010
regulation of innate immune response	GO:0045088	91	0.010
antimicrobial peptide biosynthetic process	GO:0002777	2	0.010

Trim24 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of cellular proliferation	DOID:14566	0.028	Human
cancer	DOID:162	0.028	Human
organ system cancer	DOID:0050686	0.025	Human
nervous system disease	DOID:863	0.025
disease of anatomical entity	DOID:7	0.025
sensory system disease	DOID:0050155	0.016
eye and adnexa disease	DOID:1492	0.015
immune system disease	DOID:2914	0.012
musculoskeletal system disease	DOID:17	0.011
hematopoietic system disease	DOID:74	0.011
eye disease	DOID:5614	0.011

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