Mus musculus

518 known processes

Trp53

transformation related protein 53

(Aliases: bbl,Tp53,bhy,bfy,p44,p53)

Trp53 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to dna damage stimulusGO:00069742071.000
signal transduction involved in dna damage checkpointGO:007242231.000
signal transduction involved in dna integrity checkpointGO:007240131.000
cellular response to gamma radiationGO:007148041.000
Fly
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrestGO:000697731.000
mitotic g1 dna damage checkpointGO:003157141.000
positive regulation of apoptotic process involved in mammary gland involutionGO:006005841.000
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332351.000
release of cytochrome c from mitochondriaGO:0001836231.000
cell cycle checkpointGO:0000075471.000
positive regulation of apoptotic processGO:00430652171.000
dna metabolic processGO:00062593031.000
cell agingGO:0007569351.000
cellular response to radiationGO:0071478281.000
signal transduction involved in mitotic dna damage checkpointGO:190240231.000
response to ionizing radiationGO:0010212421.000
negative regulation of mitotic cell cycleGO:0045930581.000
dna integrity checkpointGO:0031570281.000
signal transduction involved in mitotic dna integrity checkpointGO:190240331.000
signal transduction by p53 class mediatorGO:0072331511.000
signal transduction involved in cell cycle checkpointGO:007239531.000
g1 s transition of mitotic cell cycleGO:0000082571.000
negative regulation of cyclin dependent protein serine threonine kinase activityGO:004573691.000
regulation of protein stabilityGO:0031647521.000
regulation of cell cycle processGO:00105641601.000
cell cycle arrestGO:0007050371.000
regulation of mitotic cell cycleGO:00073461261.000
negative regulation of fibroblast proliferationGO:0048147141.000
apoptotic process involved in mammary gland involutionGO:006005741.000
negative regulation of protein serine threonine kinase activityGO:0071901491.000
Mouse
signal transduction involved in mitotic cell cycle checkpointGO:007241331.000
regulation of cell cycleGO:00517262811.000
regulation of mitotic cell cycle phase transitionGO:1901990731.000
negative regulation of cell cycleGO:00457861231.000
positive regulation of lymphocyte apoptotic processGO:0070230131.000
intracellular signal transduction involved in g1 dna damage checkpointGO:190240031.000
fibroblast proliferationGO:0048144351.000
covalent chromatin modificationGO:00165691631.000
intrinsic apoptotic signaling pathwayGO:00971931321.000
b cell lineage commitmentGO:000232641.000
cellular senescenceGO:0090398111.000
Human
negative regulation of mitotic cell cycle phase transitionGO:1901991451.000
negative regulation of cell cycle phase transitionGO:1901988481.000
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:009729621.000
glial cell apoptotic processGO:003434931.000
Human
dna damage checkpointGO:0000077261.000
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630571.000
regulation of fibroblast proliferationGO:0048145341.000
regulation of dna replicationGO:0006275171.000
response to x rayGO:0010165111.000
positive regulation of leukocyte apoptotic processGO:2000108211.000
dna replicationGO:0006260521.000
regulation of cell cycle g1 s phase transitionGO:1902806351.000
negative regulation of protein metabolic processGO:00512482821.000
signal transduction involved in mitotic g1 dna damage checkpointGO:007243131.000
negative regulation of dna replicationGO:000815641.000
modification dependent macromolecule catabolic processGO:00436321331.000
response to oxygen levelsGO:0070482621.000
Human Zebrafish Worm
positive regulation of peptidase activityGO:0010952491.000
Zebrafish Fly
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediatorGO:190225521.000
Mouse
cell cycle g1 s phase transitionGO:0044843571.000
negative regulation of growthGO:0045926991.000
Human
positive regulation of proteolysisGO:0045862851.000
Zebrafish Fly
positive regulation of apoptotic signaling pathwayGO:2001235951.000
Human Mouse
negative regulation of cell proliferationGO:00082852961.000
positive regulation of mitotic sister chromatid separationGO:190197021.000
mitochondrial dna repairGO:004350431.000
mitotic cell cycle arrestGO:007185041.000
t cell proliferationGO:00420981201.000
regulation of melanocyte differentiationGO:004563471.000
chromatin modificationGO:00165681871.000
negative regulation of cell cycle arrestGO:007115711.000
positive regulation of cell cycleGO:0045787921.000
regulation of cellular protein catabolic processGO:1903362611.000
negative regulation of cell sizeGO:004579231.000
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434401.000
lymphocyte proliferationGO:00466511641.000
mitotic cell cycle checkpointGO:0007093311.000
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079161.000
response to ischemiaGO:0002931141.000
regulation of cell cycle phase transitionGO:1901987771.000
regulation of g1 s transition of mitotic cell cycleGO:2000045351.000
negative regulation of cellular protein metabolic processGO:00322692471.000
negative regulation of phosphatidylinositol 3 kinase activityGO:004355311.000
Fly
regulation of cell cycle arrestGO:0071156121.000
cellular response to ionizing radiationGO:0071479111.000
negative regulation of protein modification processGO:00314001631.000
Mouse
positive regulation of mammary gland involutionGO:190352141.000
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238341.000
proteolysis involved in cellular protein catabolic processGO:00516031471.000
regulation of extrinsic apoptotic signaling pathwayGO:2001236771.000
positive regulation of cell cycle phase transitionGO:1901989171.000
negative regulation of transcription involved in g1 s transition of mitotic cell cycleGO:007193011.000
response to endoplasmic reticulum stressGO:0034976531.000
Human
dna damage response signal transduction by p53 class mediatorGO:0030330191.000
regulation of reactive oxygen species metabolic processGO:2000377401.000
negative regulation of cell cycle processGO:0010948691.000
regulation of proteasomal protein catabolic processGO:0061136461.000
positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902043131.000
regulation of cellular response to stressGO:00801351591.000
negative regulation of epithelial cell proliferationGO:0050680641.000
positive regulation of mitotic metaphase anaphase transitionGO:004584221.000
canonical wnt signaling pathway involved in negative regulation of apoptotic processGO:004433641.000
mitotic cell cycleGO:00002781951.000
regulation of protein maturationGO:1903317961.000
regulation of protein deacetylationGO:0090311171.000
ubiquitin dependent protein catabolic processGO:00065111291.000
cellular protein catabolic processGO:00442571550.999
cellular macromolecule catabolic processGO:00442652060.999
apoptotic signaling pathwayGO:00971903060.999
positive regulation of apoptotic process involved in morphogenesisGO:190233940.999
skeletal system developmentGO:00015013560.999
Mouse
regulation of transferase activityGO:00513382630.999
Mouse Fly
negative regulation of protein phosphorylationGO:00019331260.999
Mouse
positive regulation of mitotic cell cycle phase transitionGO:1901992170.999
positive regulation of chromosome organizationGO:2001252330.999
activation of cysteine type endopeptidase activityGO:0097202270.999
Fly
dna biosynthetic processGO:0071897220.999
regionalizationGO:00030023370.999
regulation of kinase activityGO:00435492490.999
Mouse Fly
regulation of ubiquitin protein transferase activityGO:005143870.999
regulation of proteolysisGO:00301621640.999
negative regulation of g1 s transition of mitotic cell cycleGO:2000134180.999
negative regulation of proteolysisGO:0045861740.999
negative regulation of phosphorylationGO:00423261660.999
Mouse Fly
leukocyte proliferationGO:00706611720.999
protein catabolic processGO:00301632210.999
striated muscle tissue developmentGO:00147062930.999
modification dependent protein catabolic processGO:00199411330.999
positive regulation of cell agingGO:009034310.999
regulation of chromosome organizationGO:0033044830.999
telomere cappingGO:001623340.999
regulation of epithelial cell proliferationGO:00506781410.999
Mouse
proteasomal protein catabolic processGO:0010498980.999
regulation of response to dna damage stimulusGO:2001020340.999
Mouse Fly
cellular response to light stimulusGO:0071482190.999
extrinsic apoptotic signaling pathwayGO:00971911260.999
protein modification by small protein conjugation or removalGO:00706472070.999
cellular response to oxidative stressGO:0034599760.999
Human
posttranscriptional regulation of gene expressionGO:00106081550.999
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.998
immature b cell differentiationGO:0002327100.998
response to radiationGO:00093141650.998
positive regulation of intrinsic apoptotic signaling pathway in response to dna damageGO:190223160.998
Mouse
epithelial cell proliferationGO:00506731740.998
Mouse
double strand break repairGO:0006302480.998
pigment cell differentiationGO:0050931270.998
mitotic cell cycle processGO:19030471590.998
regulation of protein kinase activityGO:00458592320.998
Mouse
peptidyl amino acid modificationGO:00181933360.998
melanocyte differentiationGO:0030318250.998
t cell activationGO:00421102890.998
positive regulation of glial cell proliferationGO:006025240.998
mammary gland epithelial cell proliferationGO:0033598240.998
mammary gland epithelium developmentGO:0061180650.998
response to light stimulusGO:00094161350.998
regulation of b cell apoptotic processGO:0002902130.998
positive regulation of hydrolase activityGO:00513451480.998
Zebrafish Fly
regulation of mammary gland involutionGO:190351940.998
regulation of bindingGO:00510981110.998
regulation of cellular ketone metabolic processGO:0010565660.998
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.998
Zebrafish Fly
positive regulation of ubiquitin protein transferase activityGO:005144340.998
negative regulation of molecular functionGO:00440922580.998
Mouse Fly
response to drugGO:0042493750.997
b cell activationGO:00421131610.997
protein processingGO:00164851630.997
stem cell maintenanceGO:00198271300.997
apoptotic mitochondrial changesGO:0008637480.997
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.997
negative regulation of map kinase activityGO:0043407340.997
Mouse
mammary gland involutionGO:006005690.997
chromatin organizationGO:00063252060.997
telomere maintenanceGO:0000723190.997
negative regulation of intracellular protein transportGO:0090317270.997
Fly
negative regulation of cellular protein catabolic processGO:1903363220.997
leukocyte differentiationGO:00025213420.997
cd4 positive or cd8 positive alpha beta t cell lineage commitmentGO:004336980.997
reactive oxygen species metabolic processGO:0072593840.997
positive regulation of cysteine type endopeptidase activityGO:2001056390.996
Zebrafish Fly
positive regulation of mitotic cell cycleGO:0045931410.996
negative regulation of reactive oxygen species metabolic processGO:2000378100.996
mitotic sister chromatid separationGO:005130690.996
b cell apoptotic processGO:0001783190.996
positive regulation of chromosome segregationGO:005198440.996
regulation of chromatin modificationGO:1903308570.996
pigmentationGO:0043473710.996
positive regulation of melanocyte differentiationGO:004563650.996
negative regulation of protein catabolic processGO:0042177360.996
positive regulation of dna biosynthetic processGO:200057340.996
cerebrospinal fluid secretionGO:003332640.996
Mouse
positive regulation of neuron apoptotic processGO:0043525250.995
regulation of mammary gland epithelial cell proliferationGO:0033599120.995
cellular response to abiotic stimulusGO:0071214560.995
response to oxidative stressGO:00069791230.995
dendrite regenerationGO:003110410.995
regulation of cellular amino acid metabolic processGO:000652150.995
regulation of protein catabolic processGO:00421761080.995
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.995
response to decreased oxygen levelsGO:0036293590.995
Human Zebrafish Worm
negative regulation of phosphorus metabolic processGO:00105631840.995
Mouse Fly
negative regulation of apoptotic signaling pathwayGO:20012341040.995
positive regulation of cell cycle processGO:0090068610.995
negative regulation of lipid kinase activityGO:009021910.995
Fly
lymphocyte homeostasisGO:0002260640.995
lymphocyte differentiationGO:00300982420.995
gland developmentGO:00487323300.995
Mouse
ovarian follicle developmentGO:0001541400.995
negative regulation of cellular amine metabolic processGO:003323910.995
protein ubiquitinationGO:00165671710.995
negative regulation of leukocyte differentiationGO:1902106510.995
cell fate commitmentGO:00451652100.995
regulation of apoptotic signaling pathwayGO:20012331970.995
protein localization to organelleGO:00333651850.995
negative regulation of cellular amino acid metabolic processGO:004576300.994
protein autophosphorylationGO:0046777610.994
cellular response to x rayGO:007148120.994
Fly
protein localization to nucleusGO:00345041210.994
regulation of wnt signaling pathwayGO:00301111230.994
appendage morphogenesisGO:00351071490.994
Mouse
columnar cuboidal epithelial cell differentiationGO:0002065820.994
Mouse
regulation of mitosisGO:0007088290.994
stem cell differentiationGO:00488632680.994
Fly
cellular response to nutrient levelsGO:0031669640.993
metencephalon developmentGO:0022037890.993
regulation of myeloid leukocyte differentiationGO:0002761580.993
morphogenesis of a branching epitheliumGO:00611381930.993
Mouse
t cell lineage commitmentGO:0002360130.993
positive regulation of endopeptidase activityGO:0010950430.993
Zebrafish Fly
negative regulation of organelle organizationGO:0010639900.993
negative regulation of organ growthGO:0046621170.993
regulation of cytoplasmic transportGO:19036491120.993
Fly
regulation of cell divisionGO:0051302760.992
Zebrafish Mouse
signal transduction in absence of ligandGO:0038034550.992
regulation of epidermal cell divisionGO:001048230.992
Mouse
regulation of cellular catabolic processGO:00313292420.992
regulation of microtubule polymerizationGO:003111370.992
regulation of intrinsic apoptotic signaling pathway in response to dna damageGO:1902229140.992
Mouse
negative regulation of phosphate metabolic processGO:00459361840.992
Mouse Fly
histone deacetylationGO:0016575260.992
positive regulation of cell developmentGO:00107202370.991
regulation of intracellular transportGO:00323861590.991
Fly
activation of anaphase promoting complex activityGO:005148810.991
response to hypoxiaGO:0001666580.991
Human Zebrafish Worm
mesonephric tubule developmentGO:0072164940.991
negative regulation of cell agingGO:009034450.991
axon guidanceGO:00074111410.991
negative regulation of dendritic spine morphogenesisGO:006100230.990
negative regulation of jun kinase activityGO:004350890.990
Mouse
organ growthGO:00352651170.990
Fly
regulation of autophagyGO:0010506300.990
t cell differentiation in thymusGO:0033077770.990
positive regulation of intrinsic apoptotic signaling pathwayGO:2001244250.990
Human Mouse
response to purine containing compoundGO:0014074280.990
regulation of protein localizationGO:00328802310.989
Fly
negative regulation of stem cell proliferationGO:2000647120.989
protein modification by small protein conjugationGO:00324461870.989
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.989
regulation of metaphase anaphase transition of cell cycleGO:190209990.989
regulation of transcription factor import into nucleusGO:0042990240.989
Fly
axonogenesisGO:00074092740.989
positive regulation of programmed cell deathGO:00430682180.989
hematopoietic progenitor cell differentiationGO:00022441430.989
positive regulation of fibroblast proliferationGO:0048146200.988
hair follicle morphogenesisGO:0031069290.988
Mouse
protein maturationGO:00516041760.988
negative regulation of kinase activityGO:0033673810.988
Mouse Fly
nuclear transportGO:00511691390.988
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787250.988
wnt signaling pathwayGO:00160551880.988
positive regulation of protein modification processGO:00314012990.988
ectopic germ cell programmed cell deathGO:003523490.988
Fly
negative regulation of mapk cascadeGO:0043409650.988
Mouse
regulation of endopeptidase activityGO:0052548890.987
Zebrafish Mouse Fly
epithelial tube morphogenesisGO:00605623030.986
lymphocyte apoptotic processGO:0070227540.986
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126930.986
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051220.986
negative regulation of cell cycle g1 s phase transitionGO:1902807180.986
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052310.986
protein import into nucleusGO:0006606950.985
negative regulation of cell growthGO:0030308440.985
Human
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediatorGO:0042771240.985
positive regulation of cell proliferation involved in heart valve morphogenesisGO:000325110.985
pallium developmentGO:00215431200.985
Mouse
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:2001239260.984
regulation of sequence specific dna binding transcription factor activityGO:00510901060.984
regulation of mitotic metaphase anaphase transitionGO:003007180.984
appendage developmentGO:00487361660.984
Mouse
cellular response to starvationGO:0009267570.984
response to amino acidGO:0043200370.983
neuroepithelial cell differentiationGO:0060563370.983
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.983
t cell apoptotic processGO:0070231390.983
negative regulation of cellular catabolic processGO:0031330470.983
regulation of protein modification by small protein conjugation or removalGO:1903320570.983
regenerationGO:0031099380.983
Fly
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathwayGO:190337630.982
ossificationGO:00015032160.982
cellular response to external stimulusGO:0071496880.982
positive regulation of striated muscle cell apoptotic processGO:001066330.982
negative regulation of nuclear divisionGO:0051784190.982
germ cell developmentGO:00072811850.981
Fly
response to organic cyclic compoundGO:00140701980.981
regulation of histone modificationGO:0031056560.981
negative regulation of protein maturationGO:1903318790.981
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919270.981
Fly
cellular response to peptideGO:1901653920.980
positive regulation of neuron deathGO:1901216280.980
positive regulation of organelle organizationGO:00106381280.980
positive regulation of reactive oxygen species metabolic processGO:2000379110.980
Human
positive regulation of mitochondrial membrane permeability involved in apoptotic processGO:1902110110.980
t cell homeostasisGO:0043029350.980
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436230.980
regulation of b cell differentiationGO:0045577230.979
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.979
regulation of organelle organizationGO:00330432890.979
regulation of lymphocyte proliferationGO:00506701170.979
cell divisionGO:00513011200.979
Zebrafish Mouse
negative regulation of leukocyte proliferationGO:0070664460.979
b cell differentiationGO:0030183780.979
response to uvGO:0009411440.979
regulation of protein targetingGO:1903533610.978
Fly
negative regulation of t cell proliferationGO:0042130380.978
positive regulation of wnt signaling pathwayGO:0030177450.978
regulation of pigment cell differentiationGO:005093270.978
response to alkaloidGO:0043279340.978
protein deacetylationGO:0006476320.977
macromolecule catabolic processGO:00090572810.977
positive regulation of mitosisGO:0045840140.976
sphingolipid metabolic processGO:0006665450.976
muscle cell differentiationGO:00426922610.976
negative regulation of glial cell proliferationGO:006025340.976
negative regulation of transferase activityGO:0051348850.976
Mouse Fly
erythrocyte differentiationGO:0030218880.976
positive regulation of cellular protein catabolic processGO:1903364340.976
camera type eye developmentGO:00430102660.975
response to organonitrogen compoundGO:00102432460.975
regulation of myeloid cell apoptotic processGO:0033032190.974
regulation of lymphocyte apoptotic processGO:0070228410.974
regulation of neural precursor cell proliferationGO:2000177700.974
osteoblast developmentGO:0002076170.973
negative regulation of immature t cell proliferationGO:003308730.973
zymogen activationGO:0031638410.973
Fly
response to uv bGO:001022450.973
regulation of smad protein import into nucleusGO:006039030.973
regulation of histone deacetylationGO:0031063120.972
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:200006080.972
negative regulation of mammary gland epithelial cell proliferationGO:003360030.972
response to reactive oxygen speciesGO:0000302560.972
regulation of mitotic sister chromatid segregationGO:0033047120.972
positive regulation of cellular component biogenesisGO:0044089940.971
Human
negative regulation of osteoblast proliferationGO:003368940.971
intrinsic apoptotic signaling pathway in response to oxidative stressGO:0008631190.971
embryonic organ morphogenesisGO:00485622760.971
homeostasis of number of cellsGO:00488722100.971
regulation of developmental pigmentationGO:0048070140.971
protection from non homologous end joining at telomereGO:003184840.970
chromosome separationGO:0051304140.969
regulation of transcription involved in g1 s transition of mitotic cell cycleGO:000008330.968
regulation of hippo signalingGO:003533010.968
negative regulation of intracellular transportGO:0032387380.968
Fly
positive regulation of metaphase anaphase transition of cell cycleGO:190210120.968
regulation of lipid kinase activityGO:0043550140.968
Fly
regulation of tolerance induction dependent upon immune responseGO:000265210.967
phospholipid dephosphorylationGO:004683960.967
anatomical structure homeostasisGO:00602491450.967
Zebrafish
regulation of dna templated transcription in response to stressGO:004362090.967
Fly
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.967
development of primary sexual characteristicsGO:00451371430.966
negative regulation of chromosome organizationGO:2001251300.966
metaphase anaphase transition of mitotic cell cycleGO:000709190.966
histone h3 acetylationGO:0043966140.966
positive regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathwayGO:190337830.965
positive regulation of cell deathGO:00109422240.965
mammary gland morphogenesisGO:0060443540.965
regulation of osteoblast differentiationGO:0045667670.965
regulation of nuclear cell cycle dna replicationGO:003326220.964
neuron projection guidanceGO:00974851410.964
regulation of mitochondrial membrane permeability involved in apoptotic processGO:1902108140.963
regulation of ubiquitin protein ligase activity involved in mitotic cell cycleGO:005143910.963
histone modificationGO:00165701590.963
cell growthGO:00160491300.962
Human
activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome cGO:000863540.962
endoplasmic reticulum calcium ion homeostasisGO:0032469110.962
protein deacylationGO:0035601360.962
response to corticosteroidGO:0031960200.960
protein stabilizationGO:0050821250.960
mitochondrial membrane organizationGO:0007006260.960
positive regulation of smooth muscle cell migrationGO:001491140.959
positive regulation of response to dna damage stimulusGO:2001022140.959
Mouse
nuclear divisionGO:00002801580.959
Worm Fly
mitochondrion degradationGO:000042230.959
liposaccharide metabolic processGO:1903509270.958
negative regulation of homeostatic processGO:0032845710.958
positive t cell selectionGO:0043368230.957
intra s dna damage checkpointGO:003157340.957
oocyte differentiationGO:0009994350.957
negative regulation of lymphocyte apoptotic processGO:0070229240.957
cellular response to amino acid stimulusGO:0071230290.957
regulation of sister chromatid segregationGO:0033045130.956
meiotic cell cycleGO:00513211220.955
Worm Fly
photoreceptor cell morphogenesisGO:000859430.955
cellular response to lipidGO:00713961450.955
bone developmentGO:00603481200.955
programmed necrotic cell deathGO:0097300280.954
regulation of cell morphogenesis involved in differentiationGO:00107691510.954
negative regulation of protein import into nucleusGO:0042308210.953
Fly
regulation of protein localization to nucleusGO:1900180600.953
Fly
regulation of protein import into nucleusGO:0042306520.952
Fly
negative regulation of neuron deathGO:1901215980.952
Mouse
stem cell developmentGO:00488642190.952
positive regulation of cell cycle arrestGO:0071158100.951
rhythmic processGO:00485111740.951
response to hyperoxiaGO:005509320.951
cellular lipid metabolic processGO:00442553230.951
Fly
modulation by virus of host morphology or physiologyGO:001904830.951
regulation of chromosome segregationGO:0051983210.950
positive regulation of transcription by galactoseGO:000041110.950
microtubule polymerizationGO:0046785120.950
female genitalia morphogenesisGO:004880730.949
Mouse
negative regulation of transcription factor import into nucleusGO:0042992130.949
Fly
positive regulation of growthGO:00459271040.948
Fly
positive regulation of b cell apoptotic processGO:000290440.948
positive regulation of mesenchymal cell proliferationGO:0002053330.947
Mouse
dna repairGO:00062811070.947
embryonic skeletal system developmentGO:00487061200.947
positive regulation of notch signaling pathwayGO:0045747180.947
Mouse
thymocyte apoptotic processGO:0070242190.946
regulation of cell agingGO:009034290.946
developmental programmed cell deathGO:0010623410.946
Fly
inositol phosphate catabolic processGO:007154540.946
protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:000184440.945
cellular amino acid metabolic processGO:00065201030.945
negative regulation of cell substrate adhesionGO:0010812160.945
regulation of nuclear divisionGO:0051783560.945
digestive tract developmentGO:00485651900.944
spermatogenesisGO:00072832840.944
Zebrafish
positive regulation of microtubule polymerizationGO:003111630.944
regulation of smooth muscle cell migrationGO:001491060.944
negative regulation of photoreceptor cell differentiationGO:004653340.944
Fly
jak stat cascadeGO:0007259420.942
oogenesisGO:0048477560.941
Fly
t cell homeostatic proliferationGO:000177740.941
female gamete generationGO:0007292740.941
Fly
cellular response to transforming growth factor beta stimulusGO:0071560880.941
positive regulation of antibacterial peptide biosynthetic processGO:000696310.940
t cell differentiationGO:00302171740.939
developmental pigmentationGO:0048066400.939
positive regulation of kinase activityGO:00336741550.938
response to increased oxygen levelsGO:003629620.938
positive regulation of ossificationGO:0045778470.937
double strand break repair via nonhomologous end joiningGO:0006303100.937
cellular amide metabolic processGO:0043603580.937
activation of mapkk activityGO:0000186150.937
chromatin mediated maintenance of transcriptionGO:004809620.936
canonical wnt signaling pathway involved in positive regulation of apoptotic processGO:004433730.936
positive regulation of mitochondrial membrane permeabilityGO:0035794120.936
telomere maintenance via telomeraseGO:000700410.936
response to hydrogen peroxideGO:0042542320.935
positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:006050130.935
cellular response to peptide hormone stimulusGO:0071375920.934
mitotic spindle assembly checkpointGO:000709470.933
regulation of myeloid cell differentiationGO:0045637960.933
negative regulation of cellular component organizationGO:00511291940.932
microtubule polymerization or depolymerizationGO:0031109260.932
tissue regenerationGO:0042246220.931
Fly
cellular ketone metabolic processGO:0042180840.931
regulation of cytoskeleton organizationGO:00514931220.930
cardiac endothelial cell differentiationGO:000334840.930
regulation of protein serine threonine kinase activityGO:00719001570.930
Mouse
regulation of leukocyte proliferationGO:00706631210.930
positive regulation of pigment cell differentiationGO:005094250.929
mitochondrion organizationGO:00070051340.929
mitochondrial transportGO:0006839360.928
regulation of cellular senescenceGO:200077260.927
connective tissue developmentGO:00614481790.925

Trp53 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456601.000
Human
cancerDOID:16201.000
Human
organ system cancerDOID:005068601.000
Human
endocrine gland cancerDOID:17001.000
Human
large intestine cancerDOID:567200.998
Human
colon cancerDOID:21900.998
Human
gastrointestinal system cancerDOID:311900.998
Human
intestinal cancerDOID:1015500.998
Human
colorectal cancerDOID:925600.998
Human
immune system cancerDOID:006008300.995
hematologic cancerDOID:253100.995
thyroid cancerDOID:178100.992
nervous system cancerDOID:309300.986
central nervous system cancerDOID:362000.986
pancreatic cancerDOID:179300.974
Human
prostate cancerDOID:1028300.931
male reproductive organ cancerDOID:385600.931
reproductive organ cancerDOID:19300.931