IMP: Integrative Multi-species Prediction

Mus musculus

137 known processes

Tsc1

tuberous sclerosis 1

(Aliases: hamartin,mKIAA0243)

Entrez: 64930
Ensembl: ENSMUSG00000026812
UniProtKB: Q9EP53

Process Predictions
Disease Predictions

Tsc1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of insulin receptor signaling pathway	GO:0046626	21	0.914	Fly
positive regulation of ras gtpase activity	GO:0032320	65	0.862	Human Fly
regulation of protein kinase activity	GO:0045859	232	0.858
negative regulation of insulin receptor signaling pathway	GO:0046627	14	0.845	Fly
cellular response to dna damage stimulus	GO:0006974	207	0.813
negative regulation of organ growth	GO:0046621	17	0.779	Fly
protein transport into membrane raft	GO:0032596	4	0.764
negative regulation of phosphate metabolic process	GO:0045936	184	0.709
pole plasm assembly	GO:0007315	2	0.709
cellular response to insulin stimulus	GO:0032869	78	0.698	Fly
negative regulation of transferase activity	GO:0051348	85	0.680
regulation of kinase activity	GO:0043549	249	0.676
negative regulation of cell size	GO:0045792	3	0.673
negative regulation of phosphorus metabolic process	GO:0010563	184	0.664
regulation of transcription involved in g1 s transition of mitotic cell cycle	GO:0000083	3	0.655
negative regulation of cellular protein metabolic process	GO:0032269	247	0.638	Human
lateral inhibition	GO:0046331	1	0.635
negative regulation of phosphorylation	GO:0042326	166	0.633
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.633
regulation of autophagy	GO:0010506	30	0.633	Fly
negative regulation of tor signaling	GO:0032007	13	0.632	Human Fly
ribonucleoside metabolic process	GO:0009119	245	0.631	Human Fly
positive regulation of gtpase activity	GO:0043547	85	0.590	Human Fly
gtp catabolic process	GO:0006184	143	0.588	Human Fly
purine ribonucleotide metabolic process	GO:0009150	290	0.571	Human Fly
negative regulation of protein modification process	GO:0031400	163	0.565
autophagy	GO:0006914	45	0.565	Fly
oocyte axis specification	GO:0007309	2	0.563
purine nucleoside metabolic process	GO:0042278	241	0.556	Human Fly
regulation of cell cycle	GO:0051726	281	0.552	Fly
nucleoside triphosphate metabolic process	GO:0009141	230	0.548	Human Fly
glycosyl compound catabolic process	GO:1901658	206	0.538	Human Fly
regulation of nucleotide metabolic process	GO:0006140	169	0.537	Human Fly
positive regulation of cellular catabolic process	GO:0031331	148	0.534	Human Fly
organic cyclic compound catabolic process	GO:1901361	295	0.533	Human Fly
regulation of gtp catabolic process	GO:0033124	113	0.523	Human Fly
ribonucleoside catabolic process	GO:0042454	206	0.508	Human Fly
negative regulation of growth	GO:0045926	99	0.507	Fly
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.506	Human Fly
positive regulation of autophagy	GO:0010508	9	0.505	Fly
positive regulation of nucleoside metabolic process	GO:0045979	91	0.501	Human Fly
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.494
positive regulation of nucleotide metabolic process	GO:0045981	114	0.479	Human Fly
cellular response to peptide	GO:1901653	92	0.478	Fly
cellular response to peptide hormone stimulus	GO:0071375	92	0.473	Fly
carbohydrate transport	GO:0008643	62	0.467
guanosine containing compound catabolic process	GO:1901069	144	0.466	Human Fly
negative regulation of map kinase activity	GO:0043407	34	0.463
regulation of cellular amine metabolic process	GO:0033238	20	0.463
regulation of mapk cascade	GO:0043408	248	0.456
regulation of ras protein signal transduction	GO:0046578	114	0.453	Human Fly
cellular response to organonitrogen compound	GO:0071417	145	0.453	Fly
nucleocytoplasmic transport	GO:0006913	139	0.441	Human
nucleoside phosphate metabolic process	GO:0006753	338	0.441	Human Fly
regulation of cell size	GO:0008361	72	0.436
response to insulin	GO:0032868	100	0.436	Human Fly
negative regulation of protein phosphorylation	GO:0001933	126	0.428
germ cell development	GO:0007281	185	0.427	Fly
purine containing compound metabolic process	GO:0072521	311	0.423	Human Fly
negative regulation of mapk cascade	GO:0043409	65	0.420
guanosine containing compound metabolic process	GO:1901068	144	0.418	Human Fly
positive regulation of protein modification process	GO:0031401	299	0.418
aromatic compound catabolic process	GO:0019439	286	0.408	Human Fly
neural tube closure	GO:0001843	90	0.407
nucleoside triphosphate catabolic process	GO:0009143	205	0.397	Human Fly
response to nutrient levels	GO:0031667	109	0.396	Fly
pallium development	GO:0021543	120	0.395
insulin receptor signaling pathway	GO:0008286	49	0.393	Fly
negative regulation of kinase activity	GO:0033673	81	0.392
regulation of nucleoside metabolic process	GO:0009118	130	0.389	Human Fly
positive regulation of hydrolase activity	GO:0051345	148	0.387	Human Fly
synapse organization	GO:0050808	125	0.386
cellular nitrogen compound catabolic process	GO:0044270	280	0.383	Human Fly
purine ribonucleotide catabolic process	GO:0009154	208	0.382	Human Fly
mapk cascade	GO:0000165	281	0.379
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.376	Human Fly
synaptic growth at neuromuscular junction	GO:0051124	6	0.371
response to light stimulus	GO:0009416	135	0.368
ribonucleotide metabolic process	GO:0009259	291	0.367	Human Fly
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.365	Fly
negative regulation of synapse assembly	GO:0051964	3	0.364
limbic system development	GO:0021761	72	0.349
nucleobase containing small molecule metabolic process	GO:0055086	352	0.349	Human Fly
regulation of nucleotide catabolic process	GO:0030811	122	0.348	Human Fly
positive regulation of nucleotide catabolic process	GO:0030813	88	0.342	Human Fly
posttranscriptional regulation of gene expression	GO:0010608	155	0.338	Human
regulation of purine nucleotide metabolic process	GO:1900542	169	0.332	Human Fly
purine nucleotide metabolic process	GO:0006163	302	0.330	Human Fly
negative regulation of cell cycle	GO:0045786	123	0.324
regulation of wnt signaling pathway	GO:0030111	123	0.315
response to peptide	GO:1901652	136	0.310	Human Fly
glucose import	GO:0046323	32	0.309
embryonic epithelial tube formation	GO:0001838	130	0.309
purine nucleoside catabolic process	GO:0006152	205	0.307	Human Fly
regulation of cellular catabolic process	GO:0031329	242	0.305	Human Fly
epithelial tube morphogenesis	GO:0060562	303	0.302
negative regulation of glial cell proliferation	GO:0060253	4	0.301
endomembrane system organization	GO:0010256	147	0.300
regulation of tor signaling	GO:0032006	17	0.297	Human Zebrafish Fly
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.292	Human Fly
response to organonitrogen compound	GO:0010243	246	0.290	Human Fly
developmental maturation	GO:0021700	193	0.284
response to extracellular stimulus	GO:0009991	127	0.280	Fly
chemotaxis	GO:0006935	247	0.277
regulation of transferase activity	GO:0051338	263	0.277
plasma membrane organization	GO:0007009	90	0.275
epithelial tube formation	GO:0072175	130	0.274
glucose transport	GO:0015758	56	0.268
organonitrogen compound catabolic process	GO:1901565	264	0.263	Human Fly
dna metabolic process	GO:0006259	303	0.263
oocyte anterior posterior axis specification	GO:0007314	2	0.263
regulation of cell growth	GO:0001558	91	0.263	Fly
chromosome separation	GO:0051304	14	0.263
cellular ketone metabolic process	GO:0042180	84	0.258
negative regulation of epithelial cell proliferation	GO:0050680	64	0.258
purine ribonucleoside metabolic process	GO:0046128	241	0.257	Human Fly
oocyte construction	GO:0007308	2	0.257
ribonucleotide catabolic process	GO:0009261	208	0.255	Human Fly
spermatid development	GO:0007286	108	0.253
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.250
protein localization to nucleus	GO:0034504	121	0.249
wnt signaling pathway	GO:0016055	188	0.248
epithelial cell proliferation	GO:0050673	174	0.247
regulation of cellular component size	GO:0032535	121	0.246
regulation of hippo signaling	GO:0035330	1	0.243
odontogenesis	GO:0042476	78	0.242
negative regulation of molecular function	GO:0044092	258	0.242
female gamete generation	GO:0007292	74	0.241	Fly
oocyte differentiation	GO:0009994	35	0.239
purine ribonucleoside catabolic process	GO:0046130	205	0.238	Human Fly
organ growth	GO:0035265	117	0.236	Fly
spermatid differentiation	GO:0048515	115	0.236
oogenesis	GO:0048477	56	0.234	Fly
cellular response to hormone stimulus	GO:0032870	150	0.234	Fly
protein kinase b signaling	GO:0043491	74	0.230
purine nucleotide catabolic process	GO:0006195	211	0.230	Human Fly
protein localization to organelle	GO:0033365	185	0.228
cell division	GO:0051301	120	0.224
tor signaling	GO:0031929	21	0.223	Human Zebrafish Fly
organelle fission	GO:0048285	170	0.222
nucleoside catabolic process	GO:0009164	206	0.221	Human Fly
response to radiation	GO:0009314	165	0.221
endocytosis	GO:0006897	168	0.217
response to oxygen levels	GO:0070482	62	0.216	Fly
cell growth	GO:0016049	130	0.211	Fly
establishment of protein localization to organelle	GO:0072594	118	0.211
negative regulation of cell growth	GO:0030308	44	0.210	Fly
male gamete generation	GO:0048232	285	0.210
negative regulation of protein metabolic process	GO:0051248	282	0.209	Human
glycosyl compound metabolic process	GO:1901657	246	0.199	Human Fly
acute inflammatory response	GO:0002526	41	0.198
neural tube development	GO:0021915	160	0.197
membrane organization	GO:0061024	245	0.191
regulation of mitotic cell cycle	GO:0007346	126	0.189
negative regulation of dna replication	GO:0008156	4	0.188
nucleotide metabolic process	GO:0009117	332	0.186	Human Fly
response to decreased oxygen levels	GO:0036293	59	0.186	Fly
neural tube formation	GO:0001841	108	0.184
cell type specific apoptotic process	GO:0097285	268	0.181
regulation of epithelial cell proliferation	GO:0050678	141	0.179
cell fate commitment	GO:0045165	210	0.177
regulation of actin cytoskeleton organization	GO:0032956	84	0.176	Human
regulation of protein stability	GO:0031647	52	0.174	Human
heterocycle catabolic process	GO:0046700	280	0.172	Human Fly
gtp metabolic process	GO:0046039	144	0.171	Human Fly
protein localization to plasma membrane	GO:0072659	57	0.170
negative regulation of cell proliferation	GO:0008285	296	0.169
tube closure	GO:0060606	91	0.169
actin filament organization	GO:0007015	113	0.166	Human
positive regulation of protein phosphorylation	GO:0001934	242	0.165
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.163
nucleoside phosphate catabolic process	GO:1901292	222	0.160	Human Fly
protein import into nucleus	GO:0006606	95	0.158
regulation of endocytosis	GO:0030100	69	0.157
purine containing compound catabolic process	GO:0072523	213	0.156	Human Fly
negative regulation of cellular component organization	GO:0051129	194	0.154
negative regulation of wnt signaling pathway	GO:0030178	73	0.150
cellular amine metabolic process	GO:0044106	44	0.149
positive regulation of organelle organization	GO:0010638	128	0.148
meiotic nuclear division	GO:0007126	115	0.148
protein modification by small protein conjugation or removal	GO:0070647	207	0.147
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.144	Human Fly
protein localization to membrane raft	GO:1903044	4	0.143
negative regulation of tyrosine phosphorylation of stat5 protein	GO:0042524	2	0.143
nucleotide catabolic process	GO:0009166	217	0.143	Human Fly
regulation of vesicle mediated transport	GO:0060627	139	0.142
sperm individualization	GO:0007291	1	0.141
negative regulation of cellular amine metabolic process	GO:0033239	1	0.140
angiogenesis	GO:0001525	201	0.140
cellularization	GO:0007349	1	0.139
response to nutrient	GO:0007584	12	0.139	Fly
dna damage checkpoint	GO:0000077	26	0.139
determination of adult lifespan	GO:0008340	11	0.137	Fly
regulation of cellular component biogenesis	GO:0044087	181	0.137	Human
intracellular protein transport	GO:0006886	204	0.137
cell maturation	GO:0048469	127	0.135
carbohydrate derivative catabolic process	GO:1901136	231	0.135	Human Fly
phagocytosis	GO:0006909	66	0.133
regulation of protein kinase b signaling	GO:0051896	56	0.132
ubiquitin dependent protein catabolic process	GO:0006511	129	0.131
nucleoside metabolic process	GO:0009116	246	0.131	Human Fly
protein import	GO:0017038	101	0.130
regulation of anatomical structure size	GO:0090066	178	0.128
amine metabolic process	GO:0009308	45	0.127
hippo signaling	GO:0035329	11	0.125
primary neural tube formation	GO:0014020	95	0.124
cell cell signaling involved in cell fate commitment	GO:0045168	35	0.117
nuclear import	GO:0051170	95	0.117
positive regulation of apoptotic process	GO:0043065	217	0.116
negative regulation of leukocyte differentiation	GO:1902106	51	0.115
tyrosine phosphorylation of stat5 protein	GO:0042506	9	0.115
negative regulation of protein kinase b signaling	GO:0051898	18	0.115
modification dependent protein catabolic process	GO:0019941	133	0.115
protein localization to membrane	GO:0072657	108	0.113
protein oligomerization	GO:0051259	67	0.112
modification dependent macromolecule catabolic process	GO:0043632	133	0.108
regulation of microtubule polymerization	GO:0031113	7	0.106
segmentation	GO:0035282	93	0.106
multicellular organismal aging	GO:0010259	24	0.105	Fly
muscle cell differentiation	GO:0042692	261	0.105
mitotic cell cycle	GO:0000278	195	0.104
regulation of protein localization	GO:0032880	231	0.104
chromosome segregation	GO:0007059	48	0.102
blood vessel morphogenesis	GO:0048514	285	0.102
single organism nuclear import	GO:1902593	95	0.100
g1 s transition of mitotic cell cycle	GO:0000082	57	0.099
tube formation	GO:0035148	140	0.098
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.098	Human Fly
rna localization	GO:0006403	23	0.097	Human
synapse assembly	GO:0007416	56	0.095
single organismal cell cell adhesion	GO:0016337	131	0.093
regulation of actin filament based process	GO:0032970	99	0.093	Human
skeletal system development	GO:0001501	356	0.093
actin filament bundle assembly	GO:0051017	40	0.092	Human
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.090
apoptotic signaling pathway	GO:0097190	306	0.090
negative regulation of cyclin dependent protein serine threonine kinase activity	GO:0045736	9	0.090
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	16	0.089
negative regulation of nervous system development	GO:0051961	156	0.089
negative regulation of lymphocyte activation	GO:0051250	91	0.089
intrinsic apoptotic signaling pathway	GO:0097193	132	0.087
odontogenesis of dentin containing tooth	GO:0042475	66	0.087
digestive system development	GO:0055123	200	0.085
intra s dna damage checkpoint	GO:0031573	4	0.083
protein transport within lipid bilayer	GO:0032594	5	0.082
lens development in camera type eye	GO:0002088	62	0.082
regulation of map kinase activity	GO:0043405	120	0.082
cellular response to hypoxia	GO:0071456	17	0.081	Fly
positive regulation of cytoskeleton organization	GO:0051495	49	0.081
phosphatidylinositol mediated signaling	GO:0048015	41	0.081
regionalization	GO:0003002	337	0.080
schwann cell proliferation	GO:0014010	2	0.079
establishment of protein localization to plasma membrane	GO:0090002	34	0.079
regulation of phosphatidylinositol 3 kinase signaling	GO:0014066	30	0.079
cellular response to growth factor stimulus	GO:0071363	197	0.078
insulin like growth factor receptor signaling pathway	GO:0048009	21	0.078
regulation of protein serine threonine kinase activity	GO:0071900	157	0.078
nuclear transport	GO:0051169	139	0.078	Human
negative regulation of tyrosine phosphorylation of stat3 protein	GO:0042518	1	0.078
cellular amino acid metabolic process	GO:0006520	103	0.078
macromolecule methylation	GO:0043414	120	0.078
regulation of neural precursor cell proliferation	GO:2000177	70	0.077
regulation of protein transport	GO:0051223	163	0.077
negative regulation of mitotic cell cycle	GO:0045930	58	0.076
oocyte development	GO:0048599	33	0.076
mesoderm development	GO:0007498	100	0.076
intracellular mrna localization	GO:0008298	4	0.075
methylation	GO:0032259	134	0.075
morphogenesis of embryonic epithelium	GO:0016331	159	0.074
negative regulation of tyrosine phosphorylation of stat protein	GO:0042532	3	0.074
regulation of stress fiber assembly	GO:0051492	15	0.074	Human
inositol lipid mediated signaling	GO:0048017	41	0.073
single organism cell adhesion	GO:0098602	156	0.073
negative regulation of intracellular signal transduction	GO:1902532	167	0.073	Human Fly
positive regulation of macroautophagy	GO:0016239	3	0.071
phosphatidylinositol 3 kinase signaling	GO:0014065	36	0.071
t cell differentiation	GO:0030217	174	0.071
regulation of nucleocytoplasmic transport	GO:0046822	73	0.070
protein targeting	GO:0006605	143	0.070
regulation of leukocyte differentiation	GO:1902105	159	0.070
positive regulation of microtubule polymerization	GO:0031116	3	0.069
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.069
oxidation reduction process	GO:0055114	342	0.069
cell aging	GO:0007569	35	0.069
axonogenesis	GO:0007409	274	0.069
regulation of cellular amino acid metabolic process	GO:0006521	5	0.069
digestive tract morphogenesis	GO:0048546	147	0.069
meiotic cytokinesis	GO:0033206	5	0.066
cellular macromolecule catabolic process	GO:0044265	206	0.066
regulation of synapse assembly	GO:0051963	29	0.066
regulation of cell adhesion	GO:0030155	154	0.065	Human
cell junction organization	GO:0034330	77	0.065	Human
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.064
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.064
regulation of cellular response to insulin stimulus	GO:1900076	30	0.064	Fly
signal transduction involved in mitotic dna damage checkpoint	GO:1902402	3	0.063
mesoderm morphogenesis	GO:0048332	64	0.063
inflammatory response	GO:0006954	244	0.063
organonitrogen compound biosynthetic process	GO:1901566	192	0.063
maintenance of location	GO:0051235	89	0.062
regulation of cytoskeleton organization	GO:0051493	122	0.062	Human
camera type eye development	GO:0043010	266	0.061
striated muscle tissue development	GO:0014706	293	0.061
embryonic skeletal system development	GO:0048706	120	0.061
regulation of response to drug	GO:2001023	2	0.060
response to oxidative stress	GO:0006979	123	0.060
regulation of neuron differentiation	GO:0045664	281	0.060
t cell activation	GO:0042110	289	0.058
organelle localization	GO:0051640	179	0.057
cytokinesis	GO:0000910	17	0.056
skin development	GO:0043588	220	0.056
regulation of hydrolase activity	GO:0051336	246	0.056	Human Fly
peptidyl tyrosine modification	GO:0018212	145	0.055
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.054
engulfment of apoptotic cell	GO:0043652	3	0.054
regulation of neuron apoptotic process	GO:0043523	122	0.054
cellular response to external stimulus	GO:0071496	88	0.054
regulation of membrane potential	GO:0042391	192	0.053
negative regulation of cell development	GO:0010721	169	0.053
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.053
negative regulation of transcription involved in g1 s transition of mitotic cell cycle	GO:0071930	1	0.052
regulation of cellular ketone metabolic process	GO:0010565	66	0.052
cell cell junction organization	GO:0045216	72	0.052	Human
regulation of organelle organization	GO:0033043	289	0.052	Human
cation transport	GO:0006812	399	0.052
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.052
regulation of jak stat cascade	GO:0046425	34	0.051
regulation of protein localization to nucleus	GO:1900180	60	0.051
gland development	GO:0048732	330	0.050
generation of precursor metabolites and energy	GO:0006091	103	0.050
positive regulation of cellular amine metabolic process	GO:0033240	5	0.049
cellular protein complex assembly	GO:0043623	116	0.049
hippocampus development	GO:0021766	52	0.049
regulation of canonical wnt signaling pathway	GO:0060828	82	0.048
regulation of apoptotic signaling pathway	GO:2001233	197	0.048
actin cytoskeleton organization	GO:0030036	220	0.048	Human
spermatogenesis	GO:0007283	284	0.047
negative regulation of nuclear division	GO:0051784	19	0.047
negative regulation of immune system process	GO:0002683	209	0.047
negative regulation of cell cycle process	GO:0010948	69	0.047
negative regulation of t cell activation	GO:0050868	65	0.047
microtubule cytoskeleton organization	GO:0000226	157	0.046
meiotic cell cycle	GO:0051321	122	0.046
cellular response to decreased oxygen levels	GO:0036294	18	0.046	Fly
jak stat cascade	GO:0007259	42	0.045
regulation of cell cycle process	GO:0010564	160	0.045
dendrite development	GO:0016358	115	0.045
digestive tract development	GO:0048565	190	0.045
axon guidance	GO:0007411	141	0.044
negative regulation of cell division	GO:0051782	24	0.044
regulation of nuclear division	GO:0051783	56	0.044
cellular response to starvation	GO:0009267	57	0.044
protein polymerization	GO:0051258	57	0.044
regulation of cell cycle phase transition	GO:1901987	77	0.044
protein catabolic process	GO:0030163	221	0.044
sensory perception of sound	GO:0007605	97	0.043
epidermis development	GO:0008544	187	0.043
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.043
canonical wnt signaling pathway involved in negative regulation of apoptotic process	GO:0044336	4	0.043
organelle assembly	GO:0070925	177	0.042
regulation of neuron projection development	GO:0010975	169	0.042
myeloid cell homeostasis	GO:0002262	114	0.042
lung development	GO:0030324	164	0.042
regulation of nucleotide biosynthetic process	GO:0030808	34	0.042
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	35	0.041
negative regulation of cell cycle phase transition	GO:1901988	48	0.041
positive regulation of cellular component biogenesis	GO:0044089	94	0.041	Human
circadian rhythm	GO:0007623	114	0.041
positive chemotaxis	GO:0050918	18	0.041
glial cell apoptotic process	GO:0034349	3	0.041
regulation of system process	GO:0044057	200	0.041
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.040
regulation of actin filament bundle assembly	GO:0032231	18	0.040	Human
microtubule based process	GO:0007017	236	0.040
cellular response to oxidative stress	GO:0034599	76	0.039
protein methylation	GO:0006479	81	0.039
somitogenesis	GO:0001756	69	0.039
establishment or maintenance of cell polarity	GO:0007163	86	0.039
sensory perception	GO:0007600	245	0.039
dna integrity checkpoint	GO:0031570	28	0.038
ectoderm development	GO:0007398	15	0.038
regulation of cellular response to stress	GO:0080135	159	0.038
organic acid biosynthetic process	GO:0016053	86	0.038
erythrocyte differentiation	GO:0030218	88	0.038
regulation of t cell differentiation	GO:0045580	83	0.038
nucleotide excision repair	GO:0006289	13	0.037
regulation of gliogenesis	GO:0014013	50	0.037
gene silencing	GO:0016458	38	0.037
negative regulation of organelle organization	GO:0010639	90	0.037
protein processing	GO:0016485	163	0.037
regulation of protein import into nucleus	GO:0042306	52	0.037
histone lysine methylation	GO:0034968	50	0.037
multicellular organismal signaling	GO:0035637	91	0.037
muscle cell development	GO:0055001	133	0.037
ossification	GO:0001503	216	0.036
nucleoside phosphate biosynthetic process	GO:1901293	79	0.036
dna modification	GO:0006304	50	0.036
cellular homeostasis	GO:0019725	240	0.036
apical protein localization	GO:0045176	7	0.036
regulation of cell motility	GO:2000145	236	0.036
syncytium formation by plasma membrane fusion	GO:0000768	42	0.036
regulation of lymphocyte differentiation	GO:0045619	107	0.036
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.036
positive regulation of programmed cell death	GO:0043068	218	0.036
signal transduction involved in dna damage checkpoint	GO:0072422	3	0.036
mesenchyme development	GO:0060485	152	0.035
regulation of cell projection organization	GO:0031344	206	0.035
macroautophagy	GO:0016236	21	0.035
rhythmic process	GO:0048511	174	0.035
positive regulation of cell development	GO:0010720	237	0.035
regulation of intracellular transport	GO:0032386	159	0.035
macromolecule catabolic process	GO:0009057	281	0.035
histone methylation	GO:0016571	71	0.035
cellular lipid metabolic process	GO:0044255	323	0.034
establishment or maintenance of bipolar cell polarity	GO:0061245	21	0.034
gastrulation	GO:0007369	116	0.034
myeloid leukocyte differentiation	GO:0002573	119	0.034
regulation of dna replication	GO:0006275	17	0.034
negative regulation of mammary gland epithelial cell proliferation	GO:0033600	3	0.034
cell adhesion	GO:0007155	329	0.033	Human
regulation of protein complex assembly	GO:0043254	83	0.033
regulation of lymphocyte activation	GO:0051249	240	0.033
neuron death	GO:0070997	154	0.033
dna damage response signal transduction by p53 class mediator	GO:0030330	19	0.033
leukocyte differentiation	GO:0002521	342	0.033
activation of adenylate cyclase activity	GO:0007190	4	0.033
cell cycle arrest	GO:0007050	37	0.033
energy derivation by oxidation of organic compounds	GO:0015980	77	0.033
fatty acid biosynthetic process	GO:0006633	41	0.032
negative regulation of ligase activity	GO:0051352	3	0.032
cellular response to lipid	GO:0071396	145	0.032
signal transduction by p53 class mediator	GO:0072331	51	0.032
mitotic g1 dna damage checkpoint	GO:0031571	4	0.032
regulation of blood pressure	GO:0008217	93	0.032
protein maturation	GO:0051604	176	0.032
positive regulation of smooth muscle cell migration	GO:0014911	4	0.032
carbohydrate derivative biosynthetic process	GO:1901137	183	0.032
organophosphate biosynthetic process	GO:0090407	122	0.032
regulation of lymphocyte proliferation	GO:0050670	117	0.031
ion transmembrane transport	GO:0034220	361	0.031
mitotic sister chromatid separation	GO:0051306	9	0.031
cohesin localization to chromatin	GO:0071921	1	0.031
dna replication	GO:0006260	52	0.031
myotube differentiation	GO:0014902	105	0.031
immune response activating signal transduction	GO:0002757	116	0.030
positive regulation of microtubule polymerization or depolymerization	GO:0031112	3	0.030
cellular response to oxygen levels	GO:0071453	20	0.030	Fly
somatic stem cell maintenance	GO:0035019	47	0.030
chromatin organization	GO:0006325	206	0.030
regulation of cytoplasmic transport	GO:1903649	112	0.030
regulation of ras gtpase activity	GO:0032318	88	0.030	Human Fly
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.030
negative regulation of fibroblast migration	GO:0010764	2	0.030
monocarboxylic acid metabolic process	GO:0032787	191	0.030
positive regulation of mitotic cell cycle	GO:0045931	41	0.030
positive regulation of kinase activity	GO:0033674	155	0.030
intracellular signal transduction involved in g1 dna damage checkpoint	GO:1902400	3	0.030
peptidyl tyrosine phosphorylation	GO:0018108	143	0.030
response to growth factor	GO:0070848	198	0.029
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.029
regulation of ion transport	GO:0043269	215	0.029
anatomical structure homeostasis	GO:0060249	145	0.029
regulation of macroautophagy	GO:0016241	12	0.029
regulation of feeding behavior	GO:0060259	3	0.029
gliogenesis	GO:0042063	141	0.029
ribonucleotide biosynthetic process	GO:0009260	59	0.029
negative regulation of lymphocyte differentiation	GO:0045620	32	0.029
positive regulation of rap gtpase activity	GO:0032854	3	0.029
negative regulation of rac protein signal transduction	GO:0035021	4	0.029
forebrain development	GO:0030900	302	0.028
g protein coupled receptor signaling pathway	GO:0007186	243	0.028
purine containing compound biosynthetic process	GO:0072522	70	0.028
formation of primary germ layer	GO:0001704	77	0.028
establishment of protein localization to membrane	GO:0090150	54	0.028
regulation of cell migration	GO:0030334	219	0.028
embryonic axis specification	GO:0000578	30	0.028
positive regulation of protein catabolic process	GO:0045732	60	0.028
regulation of cohesin localization to chromatin	GO:0071922	1	0.028
positive regulation of protein export from nucleus	GO:0046827	4	0.028
camp biosynthetic process	GO:0006171	31	0.027
heart morphogenesis	GO:0003007	178	0.027
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.027

Tsc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.338
cancer	DOID:162	0.133
organ system cancer	DOID:0050686	0.133
intestinal cancer	DOID:10155	0.055
gastrointestinal system cancer	DOID:3119	0.055
colon cancer	DOID:219	0.055
colorectal cancer	DOID:9256	0.055
large intestine cancer	DOID:5672	0.055
disease of metabolism	DOID:0014667	0.045
disease of anatomical entity	DOID:7	0.040
nervous system disease	DOID:863	0.040
benign neoplasm	DOID:0060072	0.037
thoracic cancer	DOID:5093	0.029

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