IMP: Integrative Multi-species Prediction

Mus musculus

126 known processes

Wdr5

WD repeat domain 5

(Aliases: AA408785,AA960360,Big-3,2410008O07Rik,Big)

Entrez: 140858
Ensembl: ENSMUSG00000026917
UniProtKB: P61965

Process Predictions
Disease Predictions

Wdr5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
chromatin modification	GO:0016568	187	0.998
histone modification	GO:0016570	159	0.996
histone methylation	GO:0016571	71	0.996
macromolecule methylation	GO:0043414	120	0.996
covalent chromatin modification	GO:0016569	163	0.995
protein methylation	GO:0006479	81	0.986
internal protein amino acid acetylation	GO:0006475	42	0.984	Human Fly
chromatin organization	GO:0006325	206	0.983
protein alkylation	GO:0008213	81	0.980
histone acetylation	GO:0016573	41	0.978	Human Fly
methylation	GO:0032259	134	0.966
transdifferentiation	GO:0060290	1	0.961	Worm
histone h3 k4 methylation	GO:0051568	23	0.926
histone lysine methylation	GO:0034968	50	0.850
peptidyl lysine modification	GO:0018205	77	0.812	Human Fly
chromatin silencing	GO:0006342	15	0.747
histone deubiquitination	GO:0016578	2	0.677
dna metabolic process	GO:0006259	303	0.659
peptidyl amino acid modification	GO:0018193	336	0.629	Human Fly
mitotic cell cycle	GO:0000278	195	0.589	Fly
gene silencing	GO:0016458	38	0.534
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter	GO:0072364	7	0.534
internal peptidyl lysine acetylation	GO:0018393	42	0.534	Human Fly
peptidyl lysine acetylation	GO:0018394	45	0.521	Human Fly
chromatin mediated maintenance of transcription	GO:0048096	2	0.476
cellular response to dna damage stimulus	GO:0006974	207	0.421	Fly
histone h3 acetylation	GO:0043966	14	0.402	Human
protein acylation	GO:0043543	64	0.376	Human Fly
negative regulation of gene expression epigenetic	GO:0045814	15	0.369
response to organic cyclic compound	GO:0014070	198	0.339
positive regulation of gluconeogenesis by positive regulation of transcription from rna polymerase ii promoter	GO:0035948	5	0.296
chromatin remodeling	GO:0006338	32	0.261	Fly
segmentation	GO:0035282	93	0.169
neural tube development	GO:0021915	160	0.168
regionalization	GO:0003002	337	0.167
intracellular receptor signaling pathway	GO:0030522	74	0.160
histone h4 acetylation	GO:0043967	10	0.146	Human
negative regulation of phosphorus metabolic process	GO:0010563	184	0.131
leukocyte differentiation	GO:0002521	342	0.130
protein deacetylation	GO:0006476	32	0.126
embryonic organ morphogenesis	GO:0048562	276	0.121
embryonic skeletal system morphogenesis	GO:0048704	91	0.119
stem cell development	GO:0048864	219	0.115
dendrite development	GO:0016358	115	0.115
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.107
positive regulation of dna templated transcription elongation	GO:0032786	2	0.103
blastocyst development	GO:0001824	80	0.100
regulation of protein stability	GO:0031647	52	0.099
signal transduction by p53 class mediator	GO:0072331	51	0.095
cellular macromolecule catabolic process	GO:0044265	206	0.094
transcription from rna polymerase i promoter	GO:0006360	13	0.086
epithelial tube morphogenesis	GO:0060562	303	0.084
cytoplasmic transport	GO:0016482	234	0.084
regulation of transcription by chromatin organization	GO:0034401	0	0.082
histone h3 k14 acetylation	GO:0044154	3	0.081
histone h3 k9 acetylation	GO:0043970	5	0.081
dna alkylation	GO:0006305	43	0.079
dna methylation	GO:0006306	43	0.079
response to estrogen	GO:0043627	24	0.078
multi multicellular organism process	GO:0044706	109	0.078
regulation of histone methylation	GO:0031060	30	0.074
amine metabolic process	GO:0009308	45	0.074
gland development	GO:0048732	330	0.074
embryonic epithelial tube formation	GO:0001838	130	0.074
response to steroid hormone	GO:0048545	56	0.073
regulation of mitotic cell cycle	GO:0007346	126	0.073	Fly
positive regulation of immature t cell proliferation	GO:0033091	4	0.070
cellular ketone metabolic process	GO:0042180	84	0.069
nuclear division	GO:0000280	158	0.069
posttranscriptional regulation of gene expression	GO:0010608	155	0.068
maturation of 5 8s rrna	GO:0000460	1	0.068
anatomical structure homeostasis	GO:0060249	145	0.065
blastocyst growth	GO:0001832	23	0.064
protein targeting	GO:0006605	143	0.063
negative regulation of molecular function	GO:0044092	258	0.063
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.062
regulation of chromosome organization	GO:0033044	83	0.061
histone h4 k12 acetylation	GO:0043983	2	0.060
telomere maintenance	GO:0000723	19	0.060
forebrain development	GO:0030900	302	0.059
somitogenesis	GO:0001756	69	0.057
germ cell development	GO:0007281	185	0.057
mitotic cell cycle process	GO:1903047	159	0.057	Fly
embryonic skeletal system development	GO:0048706	120	0.056
ribonucleoside metabolic process	GO:0009119	245	0.056
purine containing compound metabolic process	GO:0072521	311	0.055
cellular amino acid metabolic process	GO:0006520	103	0.055
response to oxidative stress	GO:0006979	123	0.054
carbohydrate biosynthetic process	GO:0016051	74	0.053
axon target recognition	GO:0007412	4	0.053
morphogenesis of embryonic epithelium	GO:0016331	159	0.052
establishment of protein localization to organelle	GO:0072594	118	0.052
oogenesis	GO:0048477	56	0.051
regulation of organelle organization	GO:0033043	289	0.051
regulation of chromatin modification	GO:1903308	57	0.050
neural tube closure	GO:0001843	90	0.050
ribose phosphate metabolic process	GO:0019693	291	0.050
gonad development	GO:0008406	141	0.048	Worm
macromolecule catabolic process	GO:0009057	281	0.048
regulation of cellular amino acid metabolic process	GO:0006521	5	0.048
digestive tract development	GO:0048565	190	0.047
hexose metabolic process	GO:0019318	98	0.047
determination of adult lifespan	GO:0008340	11	0.046	Worm
tube closure	GO:0060606	91	0.045
regulation of carbohydrate biosynthetic process	GO:0043255	40	0.045
purine nucleoside metabolic process	GO:0042278	241	0.044
cellular carbohydrate metabolic process	GO:0044262	119	0.044
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.042
regulation of histone modification	GO:0031056	56	0.042
genitalia development	GO:0048806	37	0.042
positive regulation of chromatin modification	GO:1903310	28	0.041
positive regulation of gluconeogenesis	GO:0045722	11	0.040
apoptotic signaling pathway	GO:0097190	306	0.040
nucleoside phosphate metabolic process	GO:0006753	338	0.040
regulation of nucleoside metabolic process	GO:0009118	130	0.040
camera type eye development	GO:0043010	266	0.039
nucleoside triphosphate catabolic process	GO:0009143	205	0.039
skeletal system morphogenesis	GO:0048705	203	0.039
neural tube formation	GO:0001841	108	0.038
ribonucleotide metabolic process	GO:0009259	291	0.038
regulation of cellular amine metabolic process	GO:0033238	20	0.038
mitochondrion organization	GO:0007005	134	0.037
lymphocyte differentiation	GO:0030098	242	0.037
nucleocytoplasmic transport	GO:0006913	139	0.036
nuclear transport	GO:0051169	139	0.036
negative regulation of phosphorylation	GO:0042326	166	0.036
cellular response to lipid	GO:0071396	145	0.035
regulation of chromatin organization	GO:1902275	57	0.035
regulation of intracellular transport	GO:0032386	159	0.035
protein modification by small protein conjugation or removal	GO:0070647	207	0.035
regulation of cellular ketone metabolic process	GO:0010565	66	0.035
tube formation	GO:0035148	140	0.035
response to organonitrogen compound	GO:0010243	246	0.034
regulation of kinase activity	GO:0043549	249	0.034
rna processing	GO:0006396	105	0.034
male gamete generation	GO:0048232	285	0.033
mesoderm development	GO:0007498	100	0.033
nucleoside metabolic process	GO:0009116	246	0.032
tubulin deacetylation	GO:0090042	4	0.031
glycosyl compound metabolic process	GO:1901657	246	0.030
negative regulation of cell proliferation	GO:0008285	296	0.030
multicellular organism growth	GO:0035264	161	0.030
organelle fission	GO:0048285	170	0.030
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation	GO:0060823	1	0.030
stem cell maintenance	GO:0019827	130	0.030
wnt signaling pathway	GO:0016055	188	0.030
negative regulation of cell cycle	GO:0045786	123	0.030	Fly
female gamete generation	GO:0007292	74	0.030
monosaccharide biosynthetic process	GO:0046364	44	0.029
positive regulation of transcription from rna polymerase i promoter	GO:0045943	3	0.029
negative regulation of protein modification process	GO:0031400	163	0.029
protein catabolic process	GO:0030163	221	0.028
ribosomal small subunit biogenesis	GO:0042274	4	0.028
histone h2a monoubiquitination	GO:0035518	1	0.028
axonogenesis	GO:0007409	274	0.028
male sex differentiation	GO:0046661	109	0.028
developmental maturation	GO:0021700	193	0.028
negative regulation of cellular component organization	GO:0051129	194	0.027
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000466	1	0.027
small gtpase mediated signal transduction	GO:0007264	97	0.026
cellular amine metabolic process	GO:0044106	44	0.026
response to peptide	GO:1901652	136	0.025
mrna splicing via spliceosome	GO:0000398	43	0.025
homeostasis of number of cells	GO:0048872	210	0.025
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.025
organonitrogen compound catabolic process	GO:1901565	264	0.024
cell fate commitment	GO:0045165	210	0.024
inner cell mass cell proliferation	GO:0001833	15	0.024
sensory perception	GO:0007600	245	0.023
regulation of cytoplasmic transport	GO:1903649	112	0.023
regulation of cell cycle g1 s phase transition	GO:1902806	35	0.023
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.023	Fly
nucleotide metabolic process	GO:0009117	332	0.022
nucleoside phosphate catabolic process	GO:1901292	222	0.022
t cell activation	GO:0042110	289	0.022
telencephalon development	GO:0021537	186	0.021
negative regulation of phosphate metabolic process	GO:0045936	184	0.021
urogenital system development	GO:0001655	261	0.021
nucleoside monophosphate metabolic process	GO:0009123	85	0.021
protein import into nucleus	GO:0006606	95	0.021
regulation of intracellular protein transport	GO:0033157	82	0.021
g1 s transition of mitotic cell cycle	GO:0000082	57	0.021
nucleoside catabolic process	GO:0009164	206	0.021
purine ribonucleoside metabolic process	GO:0046128	241	0.021
histone h2a ubiquitination	GO:0033522	3	0.021
regulation of leukocyte differentiation	GO:1902105	159	0.021
meiosis i	GO:0007127	60	0.021
skeletal system development	GO:0001501	356	0.021
hindbrain development	GO:0030902	128	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.020
negative regulation of cyclin dependent protein serine threonine kinase activity	GO:0045736	9	0.020
spermatogenesis	GO:0007283	284	0.020
response to light stimulus	GO:0009416	135	0.020
regulation of glucose metabolic process	GO:0010906	60	0.020
somite development	GO:0061053	81	0.020
positive regulation of cellular amine metabolic process	GO:0033240	5	0.019
circadian regulation of gene expression	GO:0032922	48	0.019
regulation of cell activation	GO:0050865	289	0.019
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.019
positive regulation of b cell activation	GO:0050871	49	0.019
response to acid chemical	GO:0001101	111	0.019
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.019
protein localization to nucleus	GO:0034504	121	0.018
positive regulation of cell activation	GO:0050867	158	0.018
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.018
dna damage response signal transduction by p53 class mediator	GO:0030330	19	0.018
development of primary male sexual characteristics	GO:0046546	88	0.018
primary neural tube formation	GO:0014020	95	0.018
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.018
canonical wnt signaling pathway	GO:0060070	130	0.017
mitotic nuclear division	GO:0007067	48	0.017
nucleus organization	GO:0006997	45	0.017
purine ribonucleotide metabolic process	GO:0009150	290	0.017
gastrulation	GO:0007369	116	0.017
monosaccharide metabolic process	GO:0005996	106	0.017
cell adhesion	GO:0007155	329	0.017
rna interference	GO:0016246	2	0.017
ras protein signal transduction	GO:0007265	77	0.017
stem cell differentiation	GO:0048863	268	0.016
protein import	GO:0017038	101	0.016
production of molecular mediator of immune response	GO:0002440	103	0.016
purine nucleotide metabolic process	GO:0006163	302	0.016
single organism nuclear import	GO:1902593	95	0.016
regulation of purine nucleotide metabolic process	GO:1900542	169	0.016
rrna processing	GO:0006364	10	0.016
intracellular protein transport	GO:0006886	204	0.016
rna 5 end processing	GO:0000966	1	0.016
carbohydrate derivative catabolic process	GO:1901136	231	0.016
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.016
purine ribonucleoside catabolic process	GO:0046130	205	0.016
positive regulation of intracellular protein transport	GO:0090316	42	0.016
positive regulation of cellular carbohydrate metabolic process	GO:0010676	29	0.016
leukocyte mediated immunity	GO:0002443	174	0.016
regulation of t cell activation	GO:0050863	170	0.016
regulation of cell cycle process	GO:0010564	160	0.016	Fly
maintenance of location	GO:0051235	89	0.015
connective tissue development	GO:0061448	179	0.015
regulation of wnt signaling pathway	GO:0030111	123	0.015
cell cycle g1 s phase transition	GO:0044843	57	0.015
ossification	GO:0001503	216	0.015
regulation of hydrolase activity	GO:0051336	246	0.015
adaptive immune response	GO:0002250	155	0.015
digestive system development	GO:0055123	200	0.015
central nervous system neuron differentiation	GO:0021953	162	0.015
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000462	1	0.015
nucleotide catabolic process	GO:0009166	217	0.015
developmental growth involved in morphogenesis	GO:0060560	138	0.015
negative regulation of protein metabolic process	GO:0051248	282	0.015
cell maturation	GO:0048469	127	0.015
purine nucleoside catabolic process	GO:0006152	205	0.015
intracellular mrna localization	GO:0008298	4	0.015
pharynx development	GO:0060465	1	0.015
cell cycle arrest	GO:0007050	37	0.015
cellular protein complex assembly	GO:0043623	116	0.015
organonitrogen compound biosynthetic process	GO:1901566	192	0.015
histone deacetylation	GO:0016575	26	0.015
myeloid cell differentiation	GO:0030099	233	0.015
response to peptide hormone	GO:0043434	127	0.014
single organism cell adhesion	GO:0098602	156	0.014
purine containing compound catabolic process	GO:0072523	213	0.014
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.014
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.014
regulation of cellular catabolic process	GO:0031329	242	0.014
regulation of nucleotide metabolic process	GO:0006140	169	0.014
branching morphogenesis of an epithelial tube	GO:0048754	159	0.014
purine nucleotide catabolic process	GO:0006195	211	0.014
regulation of proteolysis	GO:0030162	164	0.014
positive regulation of leukocyte differentiation	GO:1902107	86	0.014
regulation of epithelial cell proliferation	GO:0050678	141	0.014
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.014
regulation of myeloid cell differentiation	GO:0045637	96	0.014
rna catabolic process	GO:0006401	29	0.014
cellular protein catabolic process	GO:0044257	155	0.014
proteasomal protein catabolic process	GO:0010498	98	0.014
chromatin silencing at rdna	GO:0000183	3	0.014
blood vessel morphogenesis	GO:0048514	285	0.014
striated muscle tissue development	GO:0014706	293	0.013
nucleoside triphosphate metabolic process	GO:0009141	230	0.013
demethylation	GO:0070988	23	0.013
regulation of heart induction by regulation of canonical wnt signaling pathway	GO:0090081	2	0.013
positive regulation of growth	GO:0045927	104	0.013
leukocyte activation involved in immune response	GO:0002366	126	0.013
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.013
digestive tract morphogenesis	GO:0048546	147	0.013
nucleobase containing small molecule metabolic process	GO:0055086	352	0.013
hexose biosynthetic process	GO:0019319	39	0.013
cell type specific apoptotic process	GO:0097285	268	0.013
dna templated transcription elongation	GO:0006354	13	0.013
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.013
regulation of mrna metabolic process	GO:1903311	43	0.013
microtubule based process	GO:0007017	236	0.013
atp metabolic process	GO:0046034	75	0.013
histone h4 k16 acetylation	GO:0043984	3	0.012	Human
muscle tissue development	GO:0060537	308	0.012
cation transport	GO:0006812	399	0.012
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.012
retina development in camera type eye	GO:0060041	119	0.012
cellular response to acid chemical	GO:0071229	68	0.012
protein ubiquitination	GO:0016567	171	0.012
regulation of peptidyl lysine acetylation	GO:2000756	22	0.012
positive regulation of lymphocyte differentiation	GO:0045621	61	0.012
circulatory system process	GO:0003013	197	0.012
locomotory behavior	GO:0007626	195	0.012
cell activation involved in immune response	GO:0002263	126	0.012
dna modification	GO:0006304	50	0.012
glycosyl compound catabolic process	GO:1901658	206	0.012
heterocycle catabolic process	GO:0046700	280	0.012
humoral immune response	GO:0006959	57	0.012
positive regulation of protein modification process	GO:0031401	299	0.012
regulation of transcription from rna polymerase iii promoter	GO:0006359	2	0.012
meiotic cell cycle	GO:0051321	122	0.012
snorna metabolic process	GO:0016074	1	0.012
response to radiation	GO:0009314	165	0.012
aromatic compound catabolic process	GO:0019439	286	0.012
positive regulation of cell death	GO:0010942	224	0.012
leukocyte proliferation	GO:0070661	172	0.012
neuron death	GO:0070997	154	0.012
modification dependent macromolecule catabolic process	GO:0043632	133	0.012
lymphocyte mediated immunity	GO:0002449	139	0.012
negative regulation of cellular protein metabolic process	GO:0032269	247	0.012
negative regulation of cell cycle process	GO:0010948	69	0.012	Fly
positive regulation of carbohydrate metabolic process	GO:0045913	30	0.012
positive regulation of apoptotic process	GO:0043065	217	0.012
negative regulation of ossification	GO:0030279	49	0.012
double strand break repair	GO:0006302	48	0.012
cellular response to organonitrogen compound	GO:0071417	145	0.011
response to osmotic stress	GO:0006970	21	0.011
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.011
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.011
positive regulation of lymphocyte activation	GO:0051251	140	0.011
tissue remodeling	GO:0048771	102	0.011
histone h3 k36 methylation	GO:0010452	6	0.011
positive regulation of programmed cell death	GO:0043068	218	0.011
steroid metabolic process	GO:0008202	119	0.011
ribonucleoprotein complex subunit organization	GO:0071826	28	0.011
epithelial cell proliferation	GO:0050673	174	0.011
negative regulation of mitotic cell cycle	GO:0045930	58	0.011	Fly
regulation of protein catabolic process	GO:0042176	108	0.011
mammary gland epithelium development	GO:0061180	65	0.011
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	51	0.011
cellular response to organic cyclic compound	GO:0071407	87	0.011
regulation of histone h3 k36 methylation	GO:0000414	1	0.011
regulation of lymphocyte activation	GO:0051249	240	0.011
maternal process involved in female pregnancy	GO:0060135	32	0.011
wound healing	GO:0042060	157	0.011
ribonucleoside catabolic process	GO:0042454	206	0.011
regulation of cellular component biogenesis	GO:0044087	181	0.011
learning or memory	GO:0007611	148	0.011
regulation of protein targeting	GO:1903533	61	0.011
regulation of leukocyte proliferation	GO:0070663	121	0.011
protein deubiquitination	GO:0016579	19	0.011
regulation of antimicrobial humoral response	GO:0002759	3	0.011
organic cyclic compound catabolic process	GO:1901361	295	0.010
tricuspid valve development	GO:0003175	3	0.010
mrna transcription	GO:0009299	4	0.010
cleavage involved in rrna processing	GO:0000469	1	0.010
respiratory system development	GO:0060541	190	0.010
regulation of protein processing	GO:0070613	96	0.010
positive regulation of hydrolase activity	GO:0051345	148	0.010
regulation of cell migration	GO:0030334	219	0.010
mapk cascade	GO:0000165	281	0.010
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	16	0.010
endonucleolytic cleavage of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000479	1	0.010
protein localization to organelle	GO:0033365	185	0.010
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.010
t cell differentiation	GO:0030217	174	0.010
regulation of lymphocyte mediated immunity	GO:0002706	84	0.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.010
metaphase plate congression	GO:0051310	2	0.010
protein modification by small protein conjugation	GO:0032446	187	0.010

Wdr5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.052
nervous system disease	DOID:863	0.052
eye and adnexa disease	DOID:1492	0.030
sensory system disease	DOID:0050155	0.030
eye disease	DOID:5614	0.028
central nervous system disease	DOID:331	0.021
retinal degeneration	DOID:8466	0.014
retinal disease	DOID:5679	0.014
disease of mental health	DOID:150	0.012
neurodegenerative disease	DOID:1289	0.011

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network