IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Yars

tyrosyl-tRNA synthetase

(Aliases: AU018965,AL024047)

Ensembl: ENSMUSG00000028811
Entrez: 107271
UniProtKB: A2A7S7
UniProtKB: Q91WQ3

Process Predictions
Disease Predictions

Yars biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
amino acid activation	GO:0043038	1	0.707
trna aminoacylation for protein translation	GO:0006418	1	0.581
trna aminoacylation	GO:0043039	1	0.316
trna metabolic process	GO:0006399	11	0.313
cellular amino acid metabolic process	GO:0006520	103	0.253
translation	GO:0006412	93	0.138
trna modification	GO:0006400	9	0.101
neuron apoptotic process	GO:0051402	142	0.089
regulation of translation	GO:0006417	71	0.052
amine metabolic process	GO:0009308	45	0.050
folic acid containing compound metabolic process	GO:0006760	3	0.049
response to endoplasmic reticulum stress	GO:0034976	53	0.047
cellular amine metabolic process	GO:0044106	44	0.047
glycosyl compound catabolic process	GO:1901658	206	0.047
regulation of neuron death	GO:1901214	134	0.046
regulation of cellular ketone metabolic process	GO:0010565	66	0.046
ncrna processing	GO:0034470	26	0.044
neuromuscular process	GO:0050905	99	0.040
rna processing	GO:0006396	105	0.040
cellular response to topologically incorrect protein	GO:0035967	25	0.039
gonad development	GO:0008406	141	0.039
metencephalon development	GO:0022037	89	0.038
purine containing compound metabolic process	GO:0072521	311	0.037
carbohydrate metabolic process	GO:0005975	230	0.035
positive regulation of cellular amine metabolic process	GO:0033240	5	0.035
response to organonitrogen compound	GO:0010243	246	0.034
cellular ketone metabolic process	GO:0042180	84	0.034
neuron death	GO:0070997	154	0.033
response to amino acid	GO:0043200	37	0.033
regulation of translational elongation	GO:0006448	4	0.033
nucleotide metabolic process	GO:0009117	332	0.032
purine nucleoside metabolic process	GO:0042278	241	0.032
ribose phosphate metabolic process	GO:0019693	291	0.031
nucleoside triphosphate metabolic process	GO:0009141	230	0.031
nucleobase containing small molecule metabolic process	GO:0055086	352	0.031
endoplasmic reticulum unfolded protein response	GO:0030968	19	0.030
small gtpase mediated signal transduction	GO:0007264	97	0.030
purine ribonucleoside catabolic process	GO:0046130	205	0.029
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.029
skin development	GO:0043588	220	0.028
organonitrogen compound catabolic process	GO:1901565	264	0.028
endocytosis	GO:0006897	168	0.028
molting cycle	GO:0042303	90	0.028
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.028
nucleoside phosphate metabolic process	GO:0006753	338	0.028
transmembrane transport	GO:0055085	412	0.027
trna processing	GO:0008033	11	0.027
circadian regulation of gene expression	GO:0032922	48	0.027
ion transmembrane transport	GO:0034220	361	0.026
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.026
carbohydrate derivative biosynthetic process	GO:1901137	183	0.026
organonitrogen compound biosynthetic process	GO:1901566	192	0.025
cation transmembrane transport	GO:0098655	266	0.025
ribonucleoside catabolic process	GO:0042454	206	0.025
positive regulation of protein modification process	GO:0031401	299	0.025
purine ribonucleotide catabolic process	GO:0009154	208	0.025
carbohydrate derivative catabolic process	GO:1901136	231	0.024
neuromuscular process controlling balance	GO:0050885	59	0.024
alpha amino acid metabolic process	GO:1901605	59	0.024
purine containing compound catabolic process	GO:0072523	213	0.024
regulation of neuron apoptotic process	GO:0043523	122	0.024
germ cell development	GO:0007281	185	0.023
cerebellum development	GO:0021549	77	0.023
purine nucleotide metabolic process	GO:0006163	302	0.023
response to unfolded protein	GO:0006986	21	0.022
negative regulation of neuron apoptotic process	GO:0043524	92	0.021
regulation of cellular amine metabolic process	GO:0033238	20	0.021
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.021
nucleic acid phosphodiester bond hydrolysis	GO:0090305	49	0.021
cellular homeostasis	GO:0019725	240	0.020
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.020
positive regulation of cellular catabolic process	GO:0031331	148	0.020
cell type specific apoptotic process	GO:0097285	268	0.019
nitrogen compound transport	GO:0071705	271	0.019
cellular modified amino acid metabolic process	GO:0006575	63	0.019
purine ribonucleoside metabolic process	GO:0046128	241	0.019
cation transport	GO:0006812	399	0.019
purine ribonucleotide metabolic process	GO:0009150	290	0.018
organophosphate catabolic process	GO:0046434	232	0.018
nucleotide catabolic process	GO:0009166	217	0.018
regulation of cellular amino acid metabolic process	GO:0006521	5	0.018
cellular carbohydrate metabolic process	GO:0044262	119	0.018
ribonucleotide metabolic process	GO:0009259	291	0.018
muscle fiber development	GO:0048747	76	0.018
divalent metal ion transport	GO:0070838	172	0.018
nucleoside metabolic process	GO:0009116	246	0.017
organic cyclic compound catabolic process	GO:1901361	295	0.017
ribonucleoside metabolic process	GO:0009119	245	0.017
organophosphate biosynthetic process	GO:0090407	122	0.017
purine nucleoside catabolic process	GO:0006152	205	0.017
nucleoside catabolic process	GO:0009164	206	0.017
heterocycle catabolic process	GO:0046700	280	0.016
development of primary sexual characteristics	GO:0045137	143	0.016
ribonucleotide catabolic process	GO:0009261	208	0.016
t cell activation	GO:0042110	289	0.016
carboxylic acid transport	GO:0046942	100	0.015
lung development	GO:0030324	164	0.015
epidermis development	GO:0008544	187	0.015
aromatic compound catabolic process	GO:0019439	286	0.015
respiratory system development	GO:0060541	190	0.015
cellular nitrogen compound catabolic process	GO:0044270	280	0.015
divalent inorganic cation transport	GO:0072511	178	0.015
negative regulation of neuron death	GO:1901215	98	0.015
reactive nitrogen species metabolic process	GO:2001057	0	0.015
carboxylic acid biosynthetic process	GO:0046394	86	0.015
regulation of protein localization	GO:0032880	231	0.015
lymphocyte differentiation	GO:0030098	242	0.014
organic acid transport	GO:0015849	101	0.014
calcium ion transport	GO:0006816	159	0.014
respiratory tube development	GO:0030323	167	0.014
regulation of wnt signaling pathway	GO:0030111	123	0.014
wnt signaling pathway	GO:0016055	188	0.014
guanosine containing compound metabolic process	GO:1901068	144	0.014
l amino acid transport	GO:0015807	32	0.014
guanosine containing compound catabolic process	GO:1901069	144	0.014
nucleoside phosphate catabolic process	GO:1901292	222	0.013
maturation of 5 8s rrna	GO:0000460	1	0.013
cellular response to hormone stimulus	GO:0032870	150	0.013
regulation of transferase activity	GO:0051338	263	0.013
rhythmic process	GO:0048511	174	0.013
nucleotide biosynthetic process	GO:0009165	78	0.013
muscle tissue development	GO:0060537	308	0.013
negative regulation of phosphorus metabolic process	GO:0010563	184	0.013
hindbrain development	GO:0030902	128	0.013
methionine transport	GO:0015821	1	0.013
anion transport	GO:0006820	177	0.013
inorganic cation transmembrane transport	GO:0098662	207	0.013
regulation of organelle organization	GO:0033043	289	0.013
intracellular protein transport	GO:0006886	204	0.013
protein modification by small protein conjugation or removal	GO:0070647	207	0.012
macromolecule catabolic process	GO:0009057	281	0.012
response to topologically incorrect protein	GO:0035966	25	0.012
amino acid transport	GO:0006865	61	0.012
striated muscle cell development	GO:0055002	125	0.012
inorganic ion transmembrane transport	GO:0098660	234	0.012
rna modification	GO:0009451	20	0.012
digestive system development	GO:0055123	200	0.012
anion transmembrane transport	GO:0098656	71	0.012
leukocyte differentiation	GO:0002521	342	0.012
glycoprotein metabolic process	GO:0009100	116	0.012
protein folding	GO:0006457	28	0.012
hair follicle development	GO:0001942	85	0.012
monosaccharide metabolic process	GO:0005996	106	0.011
striated muscle tissue development	GO:0014706	293	0.011
muscle cell differentiation	GO:0042692	261	0.011
translational elongation	GO:0006414	12	0.011
regulation of cell cycle	GO:0051726	281	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.011
amino acid transmembrane transport	GO:0003333	37	0.011
purine nucleotide catabolic process	GO:0006195	211	0.011
organic acid biosynthetic process	GO:0016053	86	0.011
skeletal muscle organ development	GO:0060538	163	0.011
attachment of spindle microtubules to kinetochore	GO:0008608	4	0.011
hair cycle	GO:0042633	90	0.011
myotube differentiation	GO:0014902	105	0.011
cellular metal ion homeostasis	GO:0006875	151	0.010
branched chain amino acid transport	GO:0015803	2	0.010
regulation of muscle tissue development	GO:1901861	97	0.010
ras protein signal transduction	GO:0007265	77	0.010
protein modification by small protein conjugation	GO:0032446	187	0.010
positive regulation of protein phosphorylation	GO:0001934	242	0.010
gtp catabolic process	GO:0006184	143	0.010
response to extracellular stimulus	GO:0009991	127	0.010
protein targeting	GO:0006605	143	0.010
male gamete generation	GO:0048232	285	0.010
oxidation reduction process	GO:0055114	342	0.010
trna wobble uridine modification	GO:0002098	2	0.010
cellular chemical homeostasis	GO:0055082	215	0.010
g protein coupled receptor signaling pathway	GO:0007186	243	0.010
myeloid leukocyte differentiation	GO:0002573	119	0.010
intrinsic apoptotic signaling pathway	GO:0097193	132	0.010
negative regulation of molecular function	GO:0044092	258	0.010
mitochondrion organization	GO:0007005	134	0.010
axonogenesis	GO:0007409	274	0.010
glycosyl compound metabolic process	GO:1901657	246	0.010
posttranscriptional regulation of gene expression	GO:0010608	155	0.010

Yars disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
neuropathy	DOID:870	0.685
nervous system disease	DOID:863	0.685
disease of anatomical entity	DOID:7	0.685
neuromuscular disease	DOID:440	0.494
charcot marie tooth disease	DOID:10595	0.424
charcot marie tooth disease type 2	DOID:0050539	0.099
central nervous system disease	DOID:331	0.050
neurodegenerative disease	DOID:1289	0.050
organ system cancer	DOID:0050686	0.017
disease of cellular proliferation	DOID:14566	0.017
cancer	DOID:162	0.017
musculoskeletal system disease	DOID:17	0.010
muscular disease	DOID:0080000	0.010
muscle tissue disease	DOID:66	0.010

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