IMP: Integrative Multi-species Prediction

Mus musculus

20 known processes

Ywhag

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

(Aliases: D7Bwg1348e,14-3-3gamma)

Entrez: 22628
Ensembl: ENSMUSG00000051391
UniProtKB: P61982
UniProtKB: A8IP69

Process Predictions
Disease Predictions

Ywhag biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
oocyte axis specification	GO:0007309	2	0.983	Fly
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.888	Fly
oocyte construction	GO:0007308	2	0.884	Fly
regulation of epidermal cell division	GO:0010482	3	0.882	Mouse
inclusion body assembly	GO:0070841	3	0.839	Yeast
thermosensory behavior	GO:0040040	1	0.809	Fly
protein targeting	GO:0006605	143	0.805
nucleoside phosphate catabolic process	GO:1901292	222	0.801
intracellular protein transport	GO:0006886	204	0.788
organonitrogen compound catabolic process	GO:1901565	264	0.768
organic cyclic compound catabolic process	GO:1901361	295	0.747
nucleotide catabolic process	GO:0009166	217	0.746
cellular response to dna damage stimulus	GO:0006974	207	0.735	Yeast
negative regulation of cellular component organization	GO:0051129	194	0.721	Yeast
purine ribonucleotide catabolic process	GO:0009154	208	0.721
small gtpase mediated signal transduction	GO:0007264	97	0.704	Yeast Mouse Fly
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.700
response to organonitrogen compound	GO:0010243	246	0.686
nucleotide metabolic process	GO:0009117	332	0.682
ribonucleotide catabolic process	GO:0009261	208	0.673
ras protein signal transduction	GO:0007265	77	0.652	Yeast Fly
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.651
organophosphate catabolic process	GO:0046434	232	0.645
negative regulation of protein dephosphorylation	GO:0035308	2	0.631	Mouse
keratinocyte development	GO:0003334	10	0.630	Mouse
germ cell development	GO:0007281	185	0.606	Fly
carbohydrate derivative catabolic process	GO:1901136	231	0.602
glycosyl compound catabolic process	GO:1901658	206	0.599
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.575
nucleoside catabolic process	GO:0009164	206	0.575
heterocycle catabolic process	GO:0046700	280	0.571
pole plasm assembly	GO:0007315	2	0.570
purine ribonucleoside catabolic process	GO:0046130	205	0.566
regulation of ras protein signal transduction	GO:0046578	114	0.557	Fly
nucleoside phosphate metabolic process	GO:0006753	338	0.548
nucleoside triphosphate metabolic process	GO:0009141	230	0.541
cellular response to organonitrogen compound	GO:0071417	145	0.523
establishment of protein localization to organelle	GO:0072594	118	0.520
gtp catabolic process	GO:0006184	143	0.519
positive regulation of mapk cascade	GO:0043410	170	0.511	Fly
regulation of cellular catabolic process	GO:0031329	242	0.510
purine ribonucleotide metabolic process	GO:0009150	290	0.506
mitochondrion organization	GO:0007005	134	0.499
developmental maturation	GO:0021700	193	0.492	Fly
autophagy	GO:0006914	45	0.492
single organism nuclear import	GO:1902593	95	0.491
cellular response to insulin stimulus	GO:0032869	78	0.489
regulation of intracellular transport	GO:0032386	159	0.489	Mouse
mitotic cell cycle	GO:0000278	195	0.487	Yeast Worm Fly
negative regulation of protein metabolic process	GO:0051248	282	0.482	Yeast Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.478
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.473
nuclear transport	GO:0051169	139	0.471	Mouse
ribonucleoside catabolic process	GO:0042454	206	0.468
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.463
cell division	GO:0051301	120	0.462	Yeast Mouse Worm
purine nucleotide catabolic process	GO:0006195	211	0.460
oocyte anterior posterior axis specification	GO:0007314	2	0.447
purine nucleoside metabolic process	GO:0042278	241	0.432
ribonucleoside metabolic process	GO:0009119	245	0.432
guanosine containing compound metabolic process	GO:1901068	144	0.431
negative regulation of phosphate metabolic process	GO:0045936	184	0.426	Mouse
regulation of cell cycle	GO:0051726	281	0.425	Yeast Mouse Worm
establishment of vesicle localization	GO:0051650	81	0.410
mapk cascade	GO:0000165	281	0.405	Fly
synaptic transmission	GO:0007268	329	0.396	Human
ribonucleotide metabolic process	GO:0009259	291	0.393
regulation of protein serine threonine kinase activity	GO:0071900	157	0.391	Mouse
purine containing compound catabolic process	GO:0072523	213	0.388
regulation of cellular ketone metabolic process	GO:0010565	66	0.387
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.387
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.384
nucleoside triphosphate catabolic process	GO:0009143	205	0.381
regulation of protein export from nucleus	GO:0046825	11	0.347	Mouse
positive regulation of protein export from nucleus	GO:0046827	4	0.345	Mouse
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.345
regulation of exit from mitosis	GO:0007096	1	0.344	Yeast
oocyte differentiation	GO:0009994	35	0.343	Fly
protein heterooligomerization	GO:0051291	14	0.339
protein localization to organelle	GO:0033365	185	0.339
purine nucleoside catabolic process	GO:0006152	205	0.336
response to oxidative stress	GO:0006979	123	0.335
cytoplasmic transport	GO:0016482	234	0.334	Mouse
protein modification by small protein conjugation or removal	GO:0070647	207	0.333	Yeast
aromatic compound catabolic process	GO:0019439	286	0.333
negative regulation of transferase activity	GO:0051348	85	0.333	Yeast
protein catabolic process	GO:0030163	221	0.333
telencephalon development	GO:0021537	186	0.331	Mouse
cation transport	GO:0006812	399	0.329
negative regulation of peroxidase activity	GO:2000469	1	0.325
regionalization	GO:0003002	337	0.325	Worm
zygote asymmetric cell division	GO:0010070	2	0.324	Worm
microtubule based process	GO:0007017	236	0.323	Worm Fly
cellular ketone metabolic process	GO:0042180	84	0.322
protein modification by small protein conjugation	GO:0032446	187	0.322	Yeast
regulation of cellular response to stress	GO:0080135	159	0.312
nucleobase containing small molecule metabolic process	GO:0055086	352	0.310
regulation of protein localization	GO:0032880	231	0.308	Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	40	0.308
aggresome assembly	GO:0070842	2	0.307	Yeast
regulation of protein kinase activity	GO:0045859	232	0.305	Mouse
purine ribonucleoside metabolic process	GO:0046128	241	0.305
cellular protein catabolic process	GO:0044257	155	0.304
regulation of protein transport	GO:0051223	163	0.303	Mouse
regulation of mapk cascade	GO:0043408	248	0.302	Fly
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.297	Fly
negative regulation of ubiquitin protein transferase activity	GO:0051444	3	0.297	Yeast
female gamete generation	GO:0007292	74	0.294	Fly
vesicle localization	GO:0051648	86	0.294
establishment of organelle localization	GO:0051656	122	0.292	Worm
regulation of intracellular protein transport	GO:0033157	82	0.287	Mouse
regulation of synaptic vesicle transport	GO:1902803	13	0.280
fertilization	GO:0009566	127	0.277	Worm
positive regulation of protein kinase activity	GO:0045860	144	0.276
regulation of proteolysis	GO:0030162	164	0.276
negative regulation of phosphorus metabolic process	GO:0010563	184	0.273	Mouse
guanosine containing compound catabolic process	GO:1901069	144	0.272
purine nucleotide metabolic process	GO:0006163	302	0.271
cell fate commitment	GO:0045165	210	0.267	Worm Fly
mitochondrion distribution	GO:0048311	4	0.257
monocarboxylic acid metabolic process	GO:0032787	191	0.255
glycosyl compound metabolic process	GO:1901657	246	0.253
negative regulation of cellular protein metabolic process	GO:0032269	247	0.252	Yeast Mouse
regulation of mitochondrion organization	GO:0010821	27	0.250
oxidation reduction process	GO:0055114	342	0.246	Yeast
neurotransmitter secretion	GO:0007269	62	0.243
muscle cell differentiation	GO:0042692	261	0.236
regulation of protein stability	GO:0031647	52	0.234	Fly
oogenesis	GO:0048477	56	0.234	Fly
positive regulation of protein transport	GO:0051222	93	0.230	Mouse
establishment of mitochondrion localization	GO:0051654	4	0.220
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.218
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	56	0.217
membrane organization	GO:0061024	245	0.216
spermatogenesis	GO:0007283	284	0.215
regulation of neuron projection development	GO:0010975	169	0.213
regulation of ubiquitin protein ligase activity involved in mitotic cell cycle	GO:0051439	1	0.212	Yeast
meiotic nuclear division	GO:0007126	115	0.211	Worm
ribose phosphate metabolic process	GO:0019693	291	0.207
neurotransmitter transport	GO:0006836	76	0.206
gtp metabolic process	GO:0046039	144	0.195
epidermal cell division	GO:0010481	3	0.192	Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.188
response to organic cyclic compound	GO:0014070	198	0.186
regulation of neuron death	GO:1901214	134	0.185
protein localization to plasma membrane	GO:0072659	57	0.185
striated muscle myosin thick filament assembly	GO:0071688	1	0.184
regulation of cell projection organization	GO:0031344	206	0.184
microtubule cytoskeleton organization	GO:0000226	157	0.183	Worm Fly
purine containing compound metabolic process	GO:0072521	311	0.182
response to light stimulus	GO:0009416	135	0.181
regulation of cellular protein catabolic process	GO:1903362	61	0.181
potassium ion transport	GO:0006813	52	0.181
regulation of vesicle mediated transport	GO:0060627	139	0.180
positive regulation of growth	GO:0045927	104	0.179	Mouse
positive regulation of ras protein signal transduction	GO:0046579	13	0.175	Fly
regulation of cytoplasmic transport	GO:1903649	112	0.175	Mouse
fatty acid metabolic process	GO:0006631	121	0.174
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.174
regulation of nucleotide metabolic process	GO:0006140	169	0.173
monosaccharide metabolic process	GO:0005996	106	0.172
establishment of protein localization to membrane	GO:0090150	54	0.172
synaptic vesicle localization	GO:0097479	59	0.172
lipid biosynthetic process	GO:0008610	179	0.172
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.172	Fly
microtubule based movement	GO:0007018	84	0.167
regulation of gtp catabolic process	GO:0033124	113	0.167
locomotory behavior	GO:0007626	195	0.166
macromolecule catabolic process	GO:0009057	281	0.165
regulation of cellular amino acid metabolic process	GO:0006521	5	0.164
regulation of epithelial cell proliferation	GO:0050678	141	0.163	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.163
rac protein signal transduction	GO:0016601	13	0.163
glycerolipid biosynthetic process	GO:0045017	50	0.161
regulation of purine nucleotide catabolic process	GO:0033121	122	0.161
negative regulation of protein modification process	GO:0031400	163	0.161	Yeast Mouse
negative regulation of phosphorylation	GO:0042326	166	0.161
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.161
regulation of hydrolase activity	GO:0051336	246	0.160
male gamete generation	GO:0048232	285	0.160
regulation of neurotransmitter levels	GO:0001505	87	0.160
negative regulation of ligase activity	GO:0051352	3	0.159	Yeast
cell adhesion	GO:0007155	329	0.159
cellular macromolecule catabolic process	GO:0044265	206	0.159
glucan metabolic process	GO:0044042	32	0.158	Yeast
epithelial cell development	GO:0002064	159	0.158	Mouse
protein targeting to mitochondrion	GO:0006626	6	0.158
mitotic cell cycle process	GO:1903047	159	0.158	Yeast Worm
regulation of synaptic plasticity	GO:0048167	87	0.154	Human
regulation of protein complex assembly	GO:0043254	83	0.153
hippocampus development	GO:0021766	52	0.152	Mouse
establishment of synaptic vesicle localization	GO:0097480	57	0.152
pallium development	GO:0021543	120	0.151	Mouse
regulation of protein targeting	GO:1903533	61	0.151
dendritic spine organization	GO:0097061	26	0.149
regulation of organelle organization	GO:0033043	289	0.149	Yeast
leukocyte proliferation	GO:0070661	172	0.148
carbohydrate metabolic process	GO:0005975	230	0.147	Yeast
axon cargo transport	GO:0008088	33	0.147
establishment or maintenance of cell polarity	GO:0007163	86	0.146	Worm Fly
nucleoside metabolic process	GO:0009116	246	0.146
dephosphorylation	GO:0016311	129	0.146	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.144
protein stabilization	GO:0050821	25	0.144	Fly
regulation of actin cytoskeleton organization	GO:0032956	84	0.143
regulation of cytoskeleton organization	GO:0051493	122	0.142
intrinsic apoptotic signaling pathway	GO:0097193	132	0.142
lateral inhibition	GO:0046331	1	0.141
regulation of ion transport	GO:0043269	215	0.140
axonogenesis	GO:0007409	274	0.139
regulation of purine nucleotide metabolic process	GO:1900542	169	0.138
negative regulation of molecular function	GO:0044092	258	0.137	Yeast
protein oligomerization	GO:0051259	67	0.137
cognition	GO:0050890	149	0.137	Fly
dendrite development	GO:0016358	115	0.137
chemotaxis	GO:0006935	247	0.137
hemostasis	GO:0007599	78	0.134
positive regulation of cytoplasmic transport	GO:1903651	40	0.134	Mouse
regulation of cell growth	GO:0001558	91	0.133	Mouse
positive regulation of intracellular protein transport	GO:0090316	42	0.132	Mouse
cellular amine metabolic process	GO:0044106	44	0.130
limbic system development	GO:0021761	72	0.129	Mouse
polysaccharide metabolic process	GO:0005976	39	0.128	Yeast
intracellular mrna localization	GO:0008298	4	0.128
protein import into nucleus	GO:0006606	95	0.128
regulation of protein catabolic process	GO:0042176	108	0.128
regulation of proteasomal protein catabolic process	GO:0061136	46	0.128
positive regulation of protein phosphorylation	GO:0001934	242	0.127
cytoskeleton dependent intracellular transport	GO:0030705	50	0.125
regulation of cell cycle process	GO:0010564	160	0.124	Yeast
terminal button organization	GO:0072553	3	0.122
cell growth	GO:0016049	130	0.121	Yeast Mouse
intracellular distribution of mitochondria	GO:0048312	1	0.121
regulation of cellular component size	GO:0032535	121	0.120
dna metabolic process	GO:0006259	303	0.120	Yeast
single fertilization	GO:0007338	82	0.119	Worm
regulation of actin filament length	GO:0030832	45	0.118
neuron apoptotic process	GO:0051402	142	0.118
endocytosis	GO:0006897	168	0.118	Worm
cellular response to peptide hormone stimulus	GO:0071375	92	0.117
cellular lipid metabolic process	GO:0044255	323	0.117
regulation of ras gtpase activity	GO:0032318	88	0.116
cofactor metabolic process	GO:0051186	80	0.116
response to radiation	GO:0009314	165	0.115
proteasomal protein catabolic process	GO:0010498	98	0.114
regulation of neuron apoptotic process	GO:0043523	122	0.113
regulation of secretion by cell	GO:1903530	249	0.113
response to insulin	GO:0032868	100	0.112
actin polymerization or depolymerization	GO:0008154	54	0.112
regulation of ion transmembrane transport	GO:0034765	119	0.111
keratinocyte differentiation	GO:0030216	48	0.111	Mouse
nucleocytoplasmic transport	GO:0006913	139	0.111	Mouse
response to ammonium ion	GO:0060359	21	0.109
multicellular organism growth	GO:0035264	161	0.109
regulation of dephosphorylation	GO:0035303	18	0.108	Mouse
rho protein signal transduction	GO:0007266	32	0.107
negative regulation of organelle organization	GO:0010639	90	0.106	Yeast
regulation of ubiquitin protein transferase activity	GO:0051438	7	0.106	Yeast
gluconeogenesis	GO:0006094	39	0.105
mitochondrial transport	GO:0006839	36	0.105
chromosome segregation	GO:0007059	48	0.105	Fly
positive regulation of apoptotic process	GO:0043065	217	0.103
oocyte development	GO:0048599	33	0.103	Fly
positive regulation of gtp catabolic process	GO:0033126	85	0.102
regulation of erk1 and erk2 cascade	GO:0070372	71	0.102	Fly
inorganic cation transmembrane transport	GO:0098662	207	0.101
regulation of epidermal cell differentiation	GO:0045604	21	0.101	Mouse
cerebral cortex development	GO:0021987	86	0.101	Mouse
amine metabolic process	GO:0009308	45	0.101
activation of mapkk activity	GO:0000186	15	0.101
atp metabolic process	GO:0046034	75	0.100
organelle fission	GO:0048285	170	0.100	Yeast Worm
regulation of cell adhesion	GO:0030155	154	0.100
response to nutrient levels	GO:0031667	109	0.099
synapse organization	GO:0050808	125	0.099
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.099	Yeast
learning	GO:0007612	98	0.099
response to peptide hormone	GO:0043434	127	0.099
cellular response to hormone stimulus	GO:0032870	150	0.098
olfactory learning	GO:0008355	2	0.098
calcium ion homeostasis	GO:0055074	127	0.097
neural precursor cell proliferation	GO:0061351	121	0.097
regulation of nucleoside metabolic process	GO:0009118	130	0.096
regulation of mitotic cell cycle	GO:0007346	126	0.096	Yeast Worm
modification dependent protein catabolic process	GO:0019941	133	0.096
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.095
positive regulation of nucleoside metabolic process	GO:0045979	91	0.095
regulation of cellular component biogenesis	GO:0044087	181	0.095
dna integrity checkpoint	GO:0031570	28	0.095	Yeast
multicellular organismal aging	GO:0010259	24	0.094	Worm
energy reserve metabolic process	GO:0006112	39	0.094	Yeast
positive regulation of cell development	GO:0010720	237	0.094
modification dependent macromolecule catabolic process	GO:0043632	133	0.093
asymmetric neuroblast division	GO:0055059	1	0.092
spindle localization	GO:0051653	22	0.092	Worm
phagocytosis	GO:0006909	66	0.091
nuclear import	GO:0051170	95	0.091
cell type specific apoptotic process	GO:0097285	268	0.091
cellular response to organic cyclic compound	GO:0071407	87	0.090
nucleoside monophosphate catabolic process	GO:0009125	59	0.090
regulation of secretion	GO:0051046	274	0.089
intermediate filament based process	GO:0045103	27	0.089
posttranscriptional regulation of gene expression	GO:0010608	155	0.089	Fly
positive regulation of transferase activity	GO:0051347	167	0.089
inorganic ion transmembrane transport	GO:0098660	234	0.089
regulation of membrane potential	GO:0042391	192	0.086
positive regulation of neuron projection development	GO:0010976	79	0.085
negative regulation of mitochondrion organization	GO:0010823	9	0.085
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.085
regulation of transposition	GO:0010528	2	0.085
protein localization to nucleus	GO:0034504	121	0.085
response to peptide	GO:1901652	136	0.084
single organism cell adhesion	GO:0098602	156	0.083
protein ubiquitination	GO:0016567	171	0.082	Yeast
action potential	GO:0001508	78	0.082
apoptotic signaling pathway	GO:0097190	306	0.082
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.081
negative regulation of cell cycle	GO:0045786	123	0.081	Yeast
protein export from nucleus	GO:0006611	20	0.081	Mouse
positive regulation of nervous system development	GO:0051962	221	0.080
cellular response to oxidative stress	GO:0034599	76	0.079
positive regulation of protein modification process	GO:0031401	299	0.079
organelle localization	GO:0051640	179	0.079	Worm
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.079	Yeast
regulation of neuron differentiation	GO:0045664	281	0.078	Human
positive regulation of programmed cell death	GO:0043068	218	0.078
cellular carbohydrate metabolic process	GO:0044262	119	0.078	Yeast
cell maturation	GO:0048469	127	0.077	Fly
positive regulation of ras gtpase activity	GO:0032320	65	0.077
regulation of autophagy	GO:0010506	30	0.077
positive regulation of cell growth	GO:0030307	33	0.077	Mouse
neuron projection guidance	GO:0097485	141	0.077
regulation of terminal button organization	GO:2000331	1	0.077
telencephalon cell migration	GO:0022029	55	0.076
cellular ion homeostasis	GO:0006873	165	0.076
cell fate specification	GO:0001708	72	0.076	Worm
protein localization to membrane	GO:0072657	108	0.076
gonad development	GO:0008406	141	0.076
positive regulation of nucleotide metabolic process	GO:0045981	114	0.075
single organismal cell cell adhesion	GO:0016337	131	0.075
negative regulation of cell cycle process	GO:0010948	69	0.075	Yeast
negative regulation of protein phosphorylation	GO:0001933	126	0.075
positive regulation of cellular catabolic process	GO:0031331	148	0.074
positive regulation of cellular component biogenesis	GO:0044089	94	0.074
regulation of kinase activity	GO:0043549	249	0.073	Mouse
hexose metabolic process	GO:0019318	98	0.073
regulation of membrane depolarization	GO:0003254	11	0.073
dna damage checkpoint	GO:0000077	26	0.073	Yeast
actin filament organization	GO:0007015	113	0.073
negative regulation of nuclear division	GO:0051784	19	0.073	Yeast
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.072	Yeast
regulation of anatomical structure size	GO:0090066	178	0.071
lymphocyte proliferation	GO:0046651	164	0.071
stem cell proliferation	GO:0072089	117	0.071
atp catabolic process	GO:0006200	55	0.071
glucose metabolic process	GO:0006006	92	0.071
response to metal ion	GO:0010038	47	0.070
positive regulation of proteolysis	GO:0045862	85	0.070
peptidyl serine modification	GO:0018209	83	0.069
negative regulation of hydrolase activity	GO:0051346	71	0.069
regulation of synaptic vesicle exocytosis	GO:2000300	11	0.068
positive regulation of nucleocytoplasmic transport	GO:0046824	30	0.068	Mouse
regulation of nucleotide catabolic process	GO:0030811	122	0.067
regulation of neurotransmitter transport	GO:0051588	35	0.067
response to hypoxia	GO:0001666	58	0.067
cellular protein complex assembly	GO:0043623	116	0.067
regulation of actin filament based process	GO:0032970	99	0.067
protein import	GO:0017038	101	0.067
regulation of neurotransmitter secretion	GO:0046928	29	0.067
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.067
regulation of peroxidase activity	GO:2000468	1	0.066
positive regulation of autophagy	GO:0010508	9	0.066
negative regulation of cellular amine metabolic process	GO:0033239	1	0.066
response to inorganic substance	GO:0010035	96	0.065
cellular polysaccharide metabolic process	GO:0044264	38	0.065	Yeast
positive regulation of neuron differentiation	GO:0045666	141	0.065
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.065
coagulation	GO:0050817	78	0.064
axon guidance	GO:0007411	141	0.064
regulation of mitosis	GO:0007088	29	0.064	Yeast
muscle cell development	GO:0055001	133	0.064
neuron death	GO:0070997	154	0.064
organism emergence from protective structure	GO:0071684	4	0.064	Worm
positive regulation of nucleotide catabolic process	GO:0030813	88	0.064
synapse assembly	GO:0007416	56	0.063
cellular response to peptide	GO:1901653	92	0.063
meiotic cell cycle	GO:0051321	122	0.063	Yeast Worm
cell fate determination	GO:0001709	32	0.063	Worm Fly
negative regulation of keratinocyte proliferation	GO:0010839	7	0.063	Mouse
regulation of rho gtpase activity	GO:0032319	58	0.063
ubiquitin dependent protein catabolic process	GO:0006511	129	0.062
macroautophagy	GO:0016236	21	0.062
myosin filament organization	GO:0031033	3	0.062
protein localization to mitochondrion	GO:0070585	15	0.062
regulation of stress activated mapk cascade	GO:0032872	69	0.062
negative regulation of intracellular transport	GO:0032387	38	0.061
olfactory bulb development	GO:0021772	30	0.061
spermatid differentiation	GO:0048515	115	0.061
regulation of organ growth	GO:0046620	61	0.060
regulation of endocytosis	GO:0030100	69	0.060
establishment of melanosome localization	GO:0032401	11	0.059
divalent inorganic cation homeostasis	GO:0072507	138	0.059
organelle disassembly	GO:1903008	2	0.058
dendritic spine development	GO:0060996	30	0.058
myosin filament assembly	GO:0031034	2	0.058
regulation of transmembrane transport	GO:0034762	128	0.058
transmission of nerve impulse	GO:0019226	76	0.058
cellular response to monoamine stimulus	GO:0071868	3	0.058
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.057
regulation of metal ion transport	GO:0010959	106	0.057
cellular chemical homeostasis	GO:0055082	215	0.057
mitotic cytokinesis	GO:0000281	4	0.057
regulation of cellular amine metabolic process	GO:0033238	20	0.057
erk1 and erk2 cascade	GO:0070371	77	0.057	Fly
regulation of cellular response to oxidative stress	GO:1900407	19	0.057
mitotic spindle checkpoint	GO:0071174	9	0.057	Yeast
cellular response to ammonium ion	GO:0071242	2	0.056
establishment of protein localization to mitochondrion	GO:0072655	11	0.056
positive regulation of cell death	GO:0010942	224	0.056
positive regulation of kinase activity	GO:0033674	155	0.056
regulation of protein ubiquitination	GO:0031396	52	0.056	Yeast
regulation of protein maturation	GO:1903317	96	0.055
organic acid transport	GO:0015849	101	0.055
forebrain cell migration	GO:0021885	58	0.055
synaptic vesicle transport	GO:0048489	57	0.055
positive regulation of epidermal cell differentiation	GO:0045606	6	0.055	Mouse
membrane fusion	GO:0061025	38	0.055
phospholipid biosynthetic process	GO:0008654	36	0.055
actin filament polymerization	GO:0030041	44	0.054
negative regulation of nucleoside metabolic process	GO:0045978	11	0.054
cation homeostasis	GO:0055080	212	0.054
transmembrane transport	GO:0055085	412	0.054
regulation of protein dephosphorylation	GO:0035304	4	0.053	Mouse
ion transmembrane transport	GO:0034220	361	0.053
negative regulation of purine nucleotide catabolic process	GO:0033122	9	0.053
regulation of nucleocytoplasmic transport	GO:0046822	73	0.052	Mouse
striated muscle tissue development	GO:0014706	293	0.052
hexose biosynthetic process	GO:0019319	39	0.052
mitochondrion localization	GO:0051646	9	0.052
positive regulation of protein catabolic process	GO:0045732	60	0.052
centrosome separation	GO:0051299	4	0.052
organ growth	GO:0035265	117	0.052
regulation of peptidase activity	GO:0052547	96	0.052
regulation of establishment of protein localization	GO:0070201	181	0.051	Mouse
regulation of transporter activity	GO:0032409	57	0.051
calcium ion transport	GO:0006816	159	0.051
regulation of dendritic spine development	GO:0060998	22	0.051
actin cytoskeleton organization	GO:0030036	220	0.051
negative regulation of map kinase activity	GO:0043407	34	0.051
reactive oxygen species metabolic process	GO:0072593	84	0.051
organelle fusion	GO:0048284	28	0.051
bone resorption	GO:0045453	38	0.050
positive regulation of hydrolase activity	GO:0051345	148	0.050
myotube differentiation	GO:0014902	105	0.050
regulation of protein localization to nucleus	GO:1900180	60	0.050
developmental cell growth	GO:0048588	84	0.050
protein refolding	GO:0042026	1	0.049
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.049
negative regulation of cell proliferation	GO:0008285	296	0.049	Mouse
intermediate filament cytoskeleton organization	GO:0045104	26	0.049
microtubule based transport	GO:0010970	50	0.049
regulation of dendritic spine morphogenesis	GO:0061001	17	0.049
metal ion homeostasis	GO:0055065	189	0.049
response to decreased oxygen levels	GO:0036293	59	0.048
regulation of cell division	GO:0051302	76	0.048	Yeast Mouse
olfactory lobe development	GO:0021988	32	0.048
regulation of apoptotic signaling pathway	GO:2001233	197	0.048
carbohydrate biosynthetic process	GO:0016051	74	0.048	Yeast
positive regulation of cytoskeleton organization	GO:0051495	49	0.047
negative regulation of cellular response to insulin stimulus	GO:1900077	16	0.047
epithelial cell proliferation	GO:0050673	174	0.047	Mouse
tor signaling	GO:0031929	21	0.047
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.047
embryonic epithelial tube formation	GO:0001838	130	0.047
generation of precursor metabolites and energy	GO:0006091	103	0.047	Yeast
positive regulation of gtpase activity	GO:0043547	85	0.046
mitochondrion transport along microtubule	GO:0047497	3	0.046
regulation of stem cell proliferation	GO:0072091	78	0.046
positive regulation of jnk cascade	GO:0046330	46	0.046
asymmetric stem cell division	GO:0098722	3	0.046
nucleus localization	GO:0051647	20	0.045	Worm
nucleoside monophosphate metabolic process	GO:0009123	85	0.045
platelet activation	GO:0030168	40	0.045
cellular response to starvation	GO:0009267	57	0.044
multicellular organismal signaling	GO:0035637	91	0.044
protein depolymerization	GO:0051261	34	0.044
negative regulation of cell cycle phase transition	GO:1901988	48	0.044	Yeast

Ywhag disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
central nervous system disease	DOID:331	0.230
disease of anatomical entity	DOID:7	0.230
nervous system disease	DOID:863	0.230
musculoskeletal system disease	DOID:17	0.138
myopathy	DOID:423	0.130
muscular disease	DOID:0080000	0.130
muscle tissue disease	DOID:66	0.130
neurodegenerative disease	DOID:1289	0.074
brain disease	DOID:936	0.047

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