IMP: Integrative Multi-species Prediction

Rattus norvegicus

12 known processes

Ctsd

cathepsin D

Entrez: 171293
RGD: 621511
Ensembl: ENSRNOG00000020206
UniProtKB: Q6P6T6

Process Predictions
Disease Predictions

Ctsd biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to nutrient levels	GO:0031667	370	0.556	Yeast Mouse
response to extracellular stimulus	GO:0009991	380	0.360	Yeast Mouse
response to cytokine	GO:0034097	215	0.307
response to nutrient	GO:0007584	248	0.302
organic acid biosynthetic process	GO:0016053	83	0.242
cellular response to external stimulus	GO:0071496	118	0.237	Yeast Mouse
response to corticosteroid	GO:0031960	235	0.194
single organism catabolic process	GO:0044712	283	0.168	Yeast Mouse
regulation of apoptotic process	GO:0042981	335	0.167
response to peptide hormone	GO:0043434	278	0.154
cell projection organization	GO:0030030	302	0.143
response to monosaccharide	GO:0034284	159	0.142
response to carbohydrate	GO:0009743	183	0.135
response to hypoxia	GO:0001666	231	0.131
response to inorganic substance	GO:0010035	377	0.128
response to oxygen levels	GO:0070482	265	0.127
cellular response to stress	GO:0033554	269	0.117	Yeast Mouse
response to reactive oxygen species	GO:0000302	120	0.114
oxoacid metabolic process	GO:0043436	290	0.112
response to glucocorticoid	GO:0051384	223	0.108
monocarboxylic acid metabolic process	GO:0032787	152	0.104
response to external biotic stimulus	GO:0043207	221	0.095	Zebrafish Rat Fly
lipid metabolic process	GO:0006629	283	0.091
cellular response to mechanical stimulus	GO:0071260	48	0.089
response to decreased oxygen levels	GO:0036293	237	0.088
response to growth factor	GO:0070848	189	0.088
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.087
regeneration	GO:0031099	163	0.087
regulation of cell proliferation	GO:0042127	359	0.086
cellular response to endogenous stimulus	GO:0071495	377	0.084
neuron development	GO:0048666	286	0.080
cellular response to reactive oxygen species	GO:0034614	55	0.080
cellular response to oxygen containing compound	GO:1901701	386	0.077
small molecule biosynthetic process	GO:0044283	124	0.076
central nervous system development	GO:0007417	311	0.076
negative regulation of cell death	GO:0060548	229	0.070
cell cell signaling	GO:0007267	335	0.069
stress activated protein kinase signaling cascade	GO:0031098	37	0.067
regulation of nervous system development	GO:0051960	264	0.067
apoptotic process	GO:0006915	381	0.065	Fly
response to hexose	GO:0009746	144	0.065
carboxylic acid biosynthetic process	GO:0046394	83	0.060
response to vitamin	GO:0033273	131	0.059
response to mechanical stimulus	GO:0009612	134	0.058
positive regulation of transport	GO:0051050	245	0.056
catabolic process	GO:0009056	351	0.055
protein phosphorylation	GO:0006468	345	0.055
cellular response to hormone stimulus	GO:0032870	247	0.055
developmental process involved in reproduction	GO:0003006	159	0.055	Fly
response to oxidative stress	GO:0006979	186	0.054
response to glucose	GO:0009749	136	0.053
carboxylic acid metabolic process	GO:0019752	289	0.053
regulation of programmed cell death	GO:0043067	341	0.052
programmed cell death	GO:0012501	392	0.051	Fly
glial cell differentiation	GO:0010001	65	0.051
cellular response to nitrogen compound	GO:1901699	210	0.051
autophagy	GO:0006914	19	0.050
cellular catabolic process	GO:0044248	295	0.050
organic acid metabolic process	GO:0006082	292	0.049
cellular lipid metabolic process	GO:0044255	208	0.049
negative regulation of response to stimulus	GO:0048585	155	0.049
reproduction	GO:0000003	245	0.048	Fly
gliogenesis	GO:0042063	93	0.043
homeostatic process	GO:0042592	331	0.043
response to vitamin a	GO:0033189	36	0.042
gland development	GO:0048732	155	0.042	Fly
regulation of cell differentiation	GO:0045595	320	0.041
response to peptide	GO:1901652	292	0.040
negative regulation of cell development	GO:0010721	82	0.040
metal ion transport	GO:0030001	289	0.038
positive regulation of cell projection organization	GO:0031346	111	0.036
circadian rhythm	GO:0007623	88	0.036
multicellular organism reproduction	GO:0032504	233	0.036	Fly
neuron differentiation	GO:0030182	368	0.036
signal release	GO:0023061	145	0.036
hepaticobiliary system development	GO:0061008	90	0.036
translation	GO:0006412	35	0.035
positive regulation of cellular component organization	GO:0051130	200	0.035
synaptic transmission	GO:0007268	235	0.035
neuron projection development	GO:0031175	273	0.035
single organism reproductive process	GO:0044702	297	0.035	Fly
positive regulation of cell death	GO:0010942	184	0.034
response to metal ion	GO:0010038	253	0.034
regulation of neuron differentiation	GO:0045664	208	0.034
positive regulation of multicellular organismal process	GO:0051240	387	0.034
response to interleukin 1	GO:0070555	55	0.034
response to insulin	GO:0032868	133	0.034
positive regulation of developmental process	GO:0051094	283	0.033
negative regulation of natural killer cell mediated immunity	GO:0002716	4	0.033
response to organophosphorus	GO:0046683	102	0.033	Rat
regulation of phosphorylation	GO:0042325	248	0.033
cellular chemical homeostasis	GO:0055082	247	0.033
negative regulation of neurogenesis	GO:0050768	78	0.032
reactive oxygen species biosynthetic process	GO:1903409	8	0.031
regulation of cellular component organization	GO:0051128	368	0.031
reproductive system development	GO:0061458	128	0.031
cellular component biogenesis	GO:0044085	368	0.031	Mouse
head development	GO:0060322	247	0.031
cation transport	GO:0006812	382	0.031
regulation of peptide hormone secretion	GO:0090276	80	0.031
positive regulation of apoptotic process	GO:0043065	154	0.031
response to lipopolysaccharide	GO:0032496	191	0.031	Rat
regulation of cell projection organization	GO:0031344	175	0.030
tissue regeneration	GO:0042246	36	0.029
cellular response to nutrient levels	GO:0031669	60	0.029	Yeast Mouse
ribose phosphate metabolic process	GO:0019693	235	0.028
cellular response to abiotic stimulus	GO:0071214	85	0.028
positive regulation of peptide hormone secretion	GO:0090277	50	0.028
reproductive structure development	GO:0048608	128	0.028
cellular response to growth factor stimulus	GO:0071363	162	0.028
regulation of cellular amine metabolic process	GO:0033238	8	0.027
cellular response to nitric oxide	GO:0071732	5	0.027
chemical homeostasis	GO:0048878	292	0.027
positive regulation of programmed cell death	GO:0043068	157	0.027
protein processing	GO:0016485	68	0.026	Rat
multi organism reproductive process	GO:0044703	262	0.026	Fly
cellular response to lipid	GO:0071396	201	0.025
aging	GO:0007568	241	0.025
chemotaxis	GO:0006935	66	0.025
secretion	GO:0046903	307	0.025
decidualization	GO:0046697	14	0.024
regulation of phosphorus metabolic process	GO:0051174	349	0.024
negative regulation of neuron differentiation	GO:0045665	62	0.023
positive regulation of nervous system development	GO:0051962	178	0.023
membrane fusion	GO:0061025	26	0.023
positive regulation of biosynthetic process	GO:0009891	319	0.023
multi multicellular organism process	GO:0044706	138	0.023
positive regulation of cell development	GO:0010720	176	0.023
cellular amino acid metabolic process	GO:0006520	107	0.023
multicellular organismal signaling	GO:0035637	44	0.023
muscle tissue development	GO:0060537	58	0.023
chromatin organization	GO:0006325	34	0.023
positive regulation of cellular biosynthetic process	GO:0031328	295	0.022
response to transition metal nanoparticle	GO:1990267	122	0.022
vesicle mediated transport	GO:0016192	181	0.022
hormone transport	GO:0009914	121	0.022
male mating behavior	GO:0060179	3	0.022
regulation of molecular function	GO:0065009	398	0.022
organic substance catabolic process	GO:1901575	316	0.022	Yeast
amide transport	GO:0042886	105	0.022
reproductive process	GO:0022414	372	0.022	Fly
nucleotide metabolic process	GO:0009117	279	0.022
growth	GO:0040007	165	0.022
negative regulation of cellular component organization	GO:0051129	83	0.021
steroid metabolic process	GO:0008202	73	0.021
developmental growth	GO:0048589	100	0.021
wound healing	GO:0042060	122	0.021
cellular component assembly	GO:0022607	360	0.021	Mouse
actin filament branching	GO:0090135	1	0.020
regulation of protein metabolic process	GO:0051246	289	0.020	Rat
response to increased oxygen levels	GO:0036296	45	0.020
nitrogen compound transport	GO:0071705	229	0.020
negative regulation of cell proliferation	GO:0008285	119	0.020
regulation of secretion by cell	GO:1903530	208	0.020
reactive nitrogen species metabolic process	GO:2001057	1	0.020
endocytosis	GO:0006897	84	0.019
cholesterol homeostasis	GO:0042632	3	0.019
brain development	GO:0007420	247	0.019
insulin secretion	GO:0030073	69	0.019
ion homeostasis	GO:0050801	212	0.019
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.019
single organism biosynthetic process	GO:0044711	342	0.019
placenta development	GO:0001890	22	0.019
carbohydrate catabolic process	GO:0016052	40	0.019
carbohydrate derivative catabolic process	GO:1901136	147	0.019
cell part morphogenesis	GO:0032990	123	0.018
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.018
regulation of anatomical structure size	GO:0090066	135	0.018
regulation of multicellular organismal development	GO:2000026	376	0.018
regulation of cell size	GO:0008361	37	0.018
regulation of neurogenesis	GO:0050767	247	0.018
response to acid chemical	GO:0001101	222	0.018
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	4	0.018
anatomical structure morphogenesis	GO:0009653	298	0.018	Fly
organ regeneration	GO:0031100	101	0.018
regulation of ion transport	GO:0043269	245	0.018
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.017
positive regulation of cell communication	GO:0010647	271	0.017
regulation of extent of cell growth	GO:0061387	25	0.017
regulation of growth	GO:0040008	105	0.017
macroautophagy	GO:0016236	4	0.017	Mouse
regulation of hormone secretion	GO:0046883	106	0.017
action potential	GO:0001508	54	0.017
female pregnancy	GO:0007565	122	0.017
cellular ketone metabolic process	GO:0042180	51	0.017
cellular homeostasis	GO:0019725	252	0.017
protein homooligomerization	GO:0051260	91	0.016
hexose metabolic process	GO:0019318	58	0.016
organonitrogen compound biosynthetic process	GO:1901566	167	0.016
carbohydrate derivative metabolic process	GO:1901135	346	0.016
cell morphogenesis	GO:0000902	142	0.016
oligodendrocyte differentiation	GO:0048709	32	0.016
negative regulation of neuron projection development	GO:0010977	46	0.016
biological adhesion	GO:0022610	110	0.015
body fluid secretion	GO:0007589	41	0.015
cellular response to hypoxia	GO:0071456	51	0.015
endocrine system development	GO:0035270	30	0.015
regulation of rna metabolic process	GO:0051252	391	0.015
neuronal action potential	GO:0019228	35	0.015
cell projection morphogenesis	GO:0048858	123	0.015
multicellular organism growth	GO:0035264	1	0.015
positive regulation of rna biosynthetic process	GO:1902680	197	0.015
regulation of hormone levels	GO:0010817	187	0.015	Rat
response to ethanol	GO:0045471	162	0.015
regulation of axonogenesis	GO:0050770	37	0.015
amine metabolic process	GO:0009308	38	0.015
regulation of protein modification process	GO:0031399	194	0.015
regulation of response to external stimulus	GO:0032101	106	0.015
cellular component morphogenesis	GO:0032989	155	0.015
response to wounding	GO:0009611	254	0.015
transmission of nerve impulse	GO:0019226	42	0.014
cellular response to inorganic substance	GO:0071241	65	0.014
regulation of neuron projection development	GO:0010975	161	0.014
axonogenesis	GO:0007409	71	0.014
positive regulation of hormone secretion	GO:0046887	65	0.014
regulation of cell growth	GO:0001558	85	0.014
positive regulation of cellular amine metabolic process	GO:0033240	3	0.014
cellular amine metabolic process	GO:0044106	38	0.014
locomotion	GO:0040011	237	0.014
response to other organism	GO:0051707	220	0.014	Zebrafish Rat Fly
negative regulation of cellular protein metabolic process	GO:0032269	106	0.014
collagen catabolic process	GO:0030574	2	0.014
transcription from rna polymerase ii promoter	GO:0006366	252	0.014
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.014
positive regulation of gene expression	GO:0010628	244	0.014
peptide secretion	GO:0002790	86	0.014
macromolecular complex subunit organization	GO:0043933	339	0.014
purine containing compound metabolic process	GO:0072521	253	0.014
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.013
multicellular organismal catabolic process	GO:0044243	2	0.013
carbohydrate metabolic process	GO:0005975	130	0.013
carboxylic acid transport	GO:0046942	115	0.013
neuron projection regeneration	GO:0031102	35	0.013
regulation of vesicle mediated transport	GO:0060627	81	0.013
cellular response to extracellular stimulus	GO:0031668	73	0.013	Yeast Mouse
positive regulation of neurogenesis	GO:0050769	165	0.013
negative regulation of cell communication	GO:0010648	158	0.013
cell growth	GO:0016049	104	0.013
axon ensheathment	GO:0008366	40	0.013
proteolysis	GO:0006508	175	0.013
anion transport	GO:0006820	178	0.013
response to light stimulus	GO:0009416	52	0.013
hormone secretion	GO:0046879	115	0.013
positive regulation of insulin secretion	GO:0032024	36	0.013
regulation of cell development	GO:0060284	263	0.013
salivary gland development	GO:0007431	3	0.013	Fly
cell cell signaling involved in cell fate commitment	GO:0045168	2	0.012
cellular response to insulin stimulus	GO:0032869	81	0.012
cellular amino acid biosynthetic process	GO:0008652	32	0.012
negative regulation of nervous system development	GO:0051961	79	0.012
nucleoside phosphate metabolic process	GO:0006753	283	0.012
positive regulation of neuron differentiation	GO:0045666	126	0.012
fatty acid metabolic process	GO:0006631	99	0.012
multicellular organismal macromolecule metabolic process	GO:0044259	21	0.012
negative regulation of apoptotic process	GO:0043066	181	0.012
regulation of lipid metabolic process	GO:0019216	68	0.012
positive regulation of dna metabolic process	GO:0051054	39	0.012
cellular metal ion homeostasis	GO:0006875	172	0.012
pattern recognition receptor signaling pathway	GO:0002221	9	0.012
response to hyperoxia	GO:0055093	45	0.012
generation of precursor metabolites and energy	GO:0006091	62	0.012
regulation of peptide secretion	GO:0002791	82	0.012
positive regulation of necrotic cell death	GO:0010940	4	0.011
purine ribonucleoside monophosphate metabolic process	GO:0009167	84	0.011
positive regulation of peptide secretion	GO:0002793	52	0.011
secretion by cell	GO:0032940	248	0.011
positive regulation of ion transport	GO:0043270	94	0.011
neuron projection morphogenesis	GO:0048812	122	0.011
response to estrogen	GO:0043627	232	0.011
regulation of dna metabolic process	GO:0051052	60	0.011
protein localization	GO:0008104	191	0.011
dendrite development	GO:0016358	72	0.011
steroid biosynthetic process	GO:0006694	48	0.010
single organism intracellular transport	GO:1902582	166	0.010
glycogen metabolic process	GO:0005977	23	0.010
negative regulation of cell growth	GO:0030308	33	0.010
striated muscle tissue development	GO:0014706	58	0.010
negative regulation of multicellular organismal process	GO:0051241	203	0.010
axon extension	GO:0048675	26	0.010
regulation of rna biosynthetic process	GO:2001141	381	0.010
peptide hormone secretion	GO:0030072	84	0.010
negative regulation of signaling	GO:0023057	157	0.010
negative regulation of axon guidance	GO:1902668	3	0.010
positive regulation of molecular function	GO:0044093	230	0.010
response to camp	GO:0051591	91	0.010	Rat
maternal process involved in female pregnancy	GO:0060135	38	0.010
response to estradiol	GO:0032355	164	0.010
response to fibroblast growth factor	GO:0071774	29	0.010
reactive oxygen species metabolic process	GO:0072593	37	0.010

Ctsd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.027
disease of anatomical entity	DOID:7	0.027
nervous system disease	DOID:863	0.024
connective tissue disease	DOID:65	0.013
bone disease	DOID:0080001	0.013

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