IMP: Integrative Multi-species Prediction

Rattus norvegicus

116 known processes

LOC684425

similar to Adenylosuccinate synthetase isozyme 1 (Adenylosuccinate synthetase, muscle isozyme) (IMP--aspartate ligase 1) (AdSS 1) (AMPSase 1)

Entrez: 684425
RGD: 1590342
UniProtKB: M0R629

Process Predictions
Disease Predictions

LOC684425 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
carboxylic acid metabolic process	GO:0019752	289	0.208
organic substance catabolic process	GO:1901575	316	0.078
organic acid metabolic process	GO:0006082	292	0.073
single organism catabolic process	GO:0044712	283	0.062
single organism carbohydrate catabolic process	GO:0044724	40	0.058
oxidation reduction process	GO:0055114	304	0.058
catabolic process	GO:0009056	351	0.056
oxoacid metabolic process	GO:0043436	290	0.051
nucleobase containing small molecule metabolic process	GO:0055086	316	0.048
single organism biosynthetic process	GO:0044711	342	0.046
cellular ketone metabolic process	GO:0042180	51	0.044
cellular amino acid biosynthetic process	GO:0008652	32	0.043
tissue development	GO:0009888	252	0.040
cellular component biogenesis	GO:0044085	368	0.040
homeostatic process	GO:0042592	331	0.039
cellular catabolic process	GO:0044248	295	0.039
regulation of rna biosynthetic process	GO:2001141	381	0.038
cellular component assembly	GO:0022607	360	0.036
carbohydrate derivative metabolic process	GO:1901135	346	0.035
response to metal ion	GO:0010038	253	0.035
cell projection organization	GO:0030030	302	0.035
protein complex subunit organization	GO:0071822	302	0.035
anatomical structure morphogenesis	GO:0009653	298	0.034
cellular amino acid metabolic process	GO:0006520	107	0.034
monocarboxylic acid metabolic process	GO:0032787	152	0.034
rna metabolic process	GO:0016070	406	0.031
generation of precursor metabolites and energy	GO:0006091	62	0.030
regulation of cellular ketone metabolic process	GO:0010565	27	0.030
circulatory system process	GO:0003013	183	0.029
cellular amine metabolic process	GO:0044106	38	0.029
monovalent inorganic cation transport	GO:0015672	172	0.029
regulation of cellular component organization	GO:0051128	368	0.029
macromolecular complex assembly	GO:0065003	273	0.028
chemical homeostasis	GO:0048878	292	0.028
organophosphate metabolic process	GO:0019637	370	0.027
regulation of rna metabolic process	GO:0051252	391	0.027
protein complex biogenesis	GO:0070271	263	0.027
protein complex assembly	GO:0006461	263	0.027
carboxylic acid biosynthetic process	GO:0046394	83	0.027
cation homeostasis	GO:0055080	195	0.027
positive regulation of multicellular organismal process	GO:0051240	387	0.026
rna biosynthetic process	GO:0032774	380	0.026
protein oligomerization	GO:0051259	191	0.026
nucleoside phosphate metabolic process	GO:0006753	283	0.026
lipid metabolic process	GO:0006629	283	0.025
glycosyl compound metabolic process	GO:1901657	182	0.025
positive regulation of cell proliferation	GO:0008284	249	0.025
cellular response to oxygen containing compound	GO:1901701	386	0.025
ion homeostasis	GO:0050801	212	0.025
cellular chemical homeostasis	GO:0055082	247	0.025
cellular component movement	GO:0006928	248	0.025
regulation of apoptotic process	GO:0042981	335	0.025
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.024
programmed cell death	GO:0012501	392	0.024
monosaccharide metabolic process	GO:0005996	61	0.024
regulation of cell proliferation	GO:0042127	359	0.024
metal ion transport	GO:0030001	289	0.023
cellular component morphogenesis	GO:0032989	155	0.023
nucleotide metabolic process	GO:0009117	279	0.022
aromatic compound catabolic process	GO:0019439	168	0.022
amine metabolic process	GO:0009308	38	0.022
regulation of programmed cell death	GO:0043067	341	0.022
lipid biosynthetic process	GO:0008610	128	0.022
intracellular signal transduction	GO:0035556	314	0.021
divalent inorganic cation transport	GO:0072511	134	0.021
carbohydrate metabolic process	GO:0005975	130	0.021
regulation of cell differentiation	GO:0045595	320	0.021
organelle organization	GO:0006996	266	0.021
cardiac conduction	GO:0061337	2	0.021
positive regulation of developmental process	GO:0051094	283	0.020
positive regulation of biosynthetic process	GO:0009891	319	0.020
aging	GO:0007568	241	0.020
head development	GO:0060322	247	0.020
positive regulation of rna metabolic process	GO:0051254	203	0.020
single organism reproductive process	GO:0044702	297	0.020
purine ribonucleoside metabolic process	GO:0046128	168	0.020
nucleic acid templated transcription	GO:0097659	379	0.019
neuron development	GO:0048666	286	0.019
regulation of metal ion transport	GO:0010959	118	0.019
regulation of cellular amino acid metabolic process	GO:0006521	2	0.019
regulation of nucleic acid templated transcription	GO:1903506	380	0.019
cell cell signaling	GO:0007267	335	0.019
regulation of cellular amine metabolic process	GO:0033238	8	0.019
apoptotic process	GO:0006915	381	0.018
negative regulation of metabolic process	GO:0009892	331	0.018
cellular response to stress	GO:0033554	269	0.018
regulation of transcription dna templated	GO:0006355	374	0.018
blood circulation	GO:0008015	183	0.018
regulation of cell development	GO:0060284	263	0.018
hexose metabolic process	GO:0019318	58	0.018
single organism carbohydrate metabolic process	GO:0044723	118	0.018
macromolecular complex subunit organization	GO:0043933	339	0.018
cell communication involved in cardiac conduction	GO:0086065	2	0.018
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.018
ribonucleoside metabolic process	GO:0009119	174	0.018
negative regulation of programmed cell death	GO:0043069	183	0.018
response to decreased oxygen levels	GO:0036293	237	0.018
central nervous system development	GO:0007417	311	0.017
neuron projection morphogenesis	GO:0048812	122	0.017
intracellular transport	GO:0046907	185	0.017
regulation of multicellular organismal development	GO:2000026	376	0.017
regulation of cell growth	GO:0001558	85	0.017
neuron projection development	GO:0031175	273	0.017
response to mechanical stimulus	GO:0009612	134	0.017
cell part morphogenesis	GO:0032990	123	0.017
negative regulation of multicellular organismal process	GO:0051241	203	0.017
polysaccharide metabolic process	GO:0005976	25	0.017
organonitrogen compound biosynthetic process	GO:1901566	167	0.017
developmental process involved in reproduction	GO:0003006	159	0.017
ribose phosphate metabolic process	GO:0019693	235	0.017
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.017
cellular homeostasis	GO:0019725	252	0.017
fatty acid metabolic process	GO:0006631	99	0.016
carbohydrate catabolic process	GO:0016052	40	0.016
cellular nitrogen compound catabolic process	GO:0044270	163	0.016
regulation of stem cell differentiation	GO:2000736	2	0.016
purine nucleotide metabolic process	GO:0006163	229	0.016
multi organism reproductive process	GO:0044703	262	0.016
regulation of signal transduction	GO:0009966	318	0.016
positive regulation of gene expression	GO:0010628	244	0.016
neuron differentiation	GO:0030182	368	0.016
reproduction	GO:0000003	245	0.016
cellular ion homeostasis	GO:0006873	184	0.016
glycogen metabolic process	GO:0005977	23	0.016
response to extracellular stimulus	GO:0009991	380	0.016
response to wounding	GO:0009611	254	0.016
regulation of molecular function	GO:0065009	398	0.016
energy derivation by oxidation of organic compounds	GO:0015980	46	0.016
protein localization	GO:0008104	191	0.016
cellular polysaccharide metabolic process	GO:0044264	23	0.016
reproductive process	GO:0022414	372	0.015
positive regulation of cellular amine metabolic process	GO:0033240	3	0.015
potassium ion transport	GO:0006813	97	0.015
purine nucleoside metabolic process	GO:0042278	169	0.015
protein tetramerization	GO:0051262	38	0.015
cellular protein localization	GO:0034613	122	0.015
gastrulation	GO:0007369	2	0.015
cation transport	GO:0006812	382	0.015
secretion	GO:0046903	307	0.015
positive regulation of cellular biosynthetic process	GO:0031328	295	0.015
negative regulation of cell communication	GO:0010648	158	0.015
regulation of phosphate metabolic process	GO:0019220	349	0.015
positive regulation of cell development	GO:0010720	176	0.015
multicellular organismal signaling	GO:0035637	44	0.015
nucleobase containing compound catabolic process	GO:0034655	152	0.014
regulation of cellular component movement	GO:0051270	150	0.014
negative regulation of transport	GO:0051051	136	0.014
reproductive structure development	GO:0048608	128	0.014
regulation of membrane potential	GO:0042391	110	0.014
regulation of intracellular signal transduction	GO:1902531	218	0.014
regulation of phosphorus metabolic process	GO:0051174	349	0.014
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.014
positive regulation of rna biosynthetic process	GO:1902680	197	0.014
gland development	GO:0048732	155	0.014
locomotion	GO:0040011	237	0.014
alpha amino acid metabolic process	GO:1901605	71	0.014
nucleoside metabolic process	GO:0009116	179	0.014
cellular response to fluid shear stress	GO:0071498	4	0.014
cell growth	GO:0016049	104	0.014
response to oxygen levels	GO:0070482	265	0.014
cellular macromolecule localization	GO:0070727	122	0.014
transcription from rna polymerase ii promoter	GO:0006366	252	0.014
regulation of cell projection organization	GO:0031344	175	0.014
small gtpase mediated signal transduction	GO:0007264	36	0.014
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.013
regulation of protein metabolic process	GO:0051246	289	0.013
growth	GO:0040007	165	0.013
glucose metabolic process	GO:0006006	52	0.013
single organism intracellular transport	GO:1902582	166	0.013
purine ribonucleotide metabolic process	GO:0009150	227	0.013
organic acid biosynthetic process	GO:0016053	83	0.013
brain development	GO:0007420	247	0.013
metal ion homeostasis	GO:0055065	186	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.013
cellular glucan metabolic process	GO:0006073	23	0.013
neurological system process	GO:0050877	219	0.013
macromolecule localization	GO:0033036	252	0.013
single organism organelle organization	GO:1902589	180	0.013
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.013
ribonucleotide metabolic process	GO:0009259	231	0.013
negative regulation of cellular biosynthetic process	GO:0031327	161	0.013
cell morphogenesis	GO:0000902	142	0.013
nucleotide catabolic process	GO:0009166	139	0.013
divalent inorganic cation homeostasis	GO:0072507	165	0.013
organophosphate biosynthetic process	GO:0090407	143	0.013
regulation of neuron projection development	GO:0010975	161	0.013
response to estrogen	GO:0043627	232	0.013
response to hypoxia	GO:0001666	231	0.013
organonitrogen compound catabolic process	GO:1901565	179	0.013
regulation of secretion by cell	GO:1903530	208	0.013
cell projection morphogenesis	GO:0048858	123	0.012
organic cyclic compound catabolic process	GO:1901361	175	0.012
multicellular organism growth	GO:0035264	1	0.012
heart development	GO:0007507	72	0.012
cellular response to lipid	GO:0071396	201	0.012
protein phosphorylation	GO:0006468	345	0.012
negative regulation of cellular metabolic process	GO:0031324	281	0.012
regulation of cellular localization	GO:0060341	263	0.012
ras protein signal transduction	GO:0007265	29	0.012
positive regulation of intracellular signal transduction	GO:1902533	138	0.012
positive regulation of cell differentiation	GO:0045597	217	0.012
heart morphogenesis	GO:0003007	3	0.012
negative regulation of cell differentiation	GO:0045596	99	0.012
regulation of catabolic process	GO:0009894	113	0.012
regulation of proteasomal protein catabolic process	GO:0061136	4	0.012
response to ethanol	GO:0045471	162	0.012
transcription dna templated	GO:0006351	377	0.012
secretion by cell	GO:0032940	248	0.012
regulation of ion transport	GO:0043269	245	0.012
regulation of nervous system development	GO:0051960	264	0.012
female pregnancy	GO:0007565	122	0.012
positive regulation of cell communication	GO:0010647	271	0.012
response to glucose	GO:0009749	136	0.012
negative regulation of apoptotic process	GO:0043066	181	0.012
regulation of hormone levels	GO:0010817	187	0.012
purine containing compound metabolic process	GO:0072521	253	0.012
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.012
cell motility	GO:0048870	202	0.011
urogenital system development	GO:0001655	78	0.011
response to monosaccharide	GO:0034284	159	0.011
transmembrane transport	GO:0055085	412	0.011
cytosolic calcium ion homeostasis	GO:0051480	140	0.011
membrane repolarization	GO:0086009	1	0.011
eye morphogenesis	GO:0048592	4	0.011
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.011
establishment of protein localization	GO:0045184	141	0.011
multicellular organismal reproductive process	GO:0048609	233	0.011
vitamin a metabolic process	GO:0006776	2	0.011
purine nucleotide catabolic process	GO:0006195	136	0.011
positive regulation of cellular component organization	GO:0051130	200	0.011
purine containing compound catabolic process	GO:0072523	138	0.011
regulation of system process	GO:0044057	208	0.011
heterocycle catabolic process	GO:0046700	167	0.011
positive regulation of signal transduction	GO:0009967	175	0.011
positive regulation of cell projection organization	GO:0031346	111	0.011
muscle structure development	GO:0061061	87	0.011
carbohydrate derivative catabolic process	GO:1901136	147	0.011
response to acid chemical	GO:0001101	222	0.011
circulatory system development	GO:0072359	134	0.011
immune system process	GO:0002376	204	0.011
cellular carbohydrate metabolic process	GO:0044262	72	0.011
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.011
energy reserve metabolic process	GO:0006112	25	0.011
lipid storage	GO:0019915	1	0.011
response to inorganic substance	GO:0010035	377	0.011
spermatogenesis	GO:0007283	99	0.011
cell migration	GO:0016477	197	0.011
coenzyme metabolic process	GO:0006732	86	0.010
calcium ion transport	GO:0006816	131	0.010
regulation of neurogenesis	GO:0050767	247	0.010
positive regulation of neuron projection development	GO:0010976	99	0.010
hepaticobiliary system development	GO:0061008	90	0.010
multi multicellular organism process	GO:0044706	138	0.010
proteolysis	GO:0006508	175	0.010
muscle system process	GO:0003012	115	0.010
sexual reproduction	GO:0019953	148	0.010
glycolytic process	GO:0006096	17	0.010
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.010
cytoplasmic transport	GO:0016482	115	0.010
embryonic pattern specification	GO:0009880	1	0.010
cardiovascular system development	GO:0072358	134	0.010
cellular cation homeostasis	GO:0030003	180	0.010
positive regulation of signaling	GO:0023056	270	0.010
regulation of anatomical structure size	GO:0090066	135	0.010

LOC684425 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.017
nervous system disease	DOID:863	0.017
disease of metabolism	DOID:0014667	0.013
musculoskeletal system disease	DOID:17	0.012
inherited metabolic disorder	DOID:655	0.010

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