Rattus norvegicus

0 known processes

Tmem45b

transmembrane protein 45b

(Aliases: MGC124767,RGD1305586)

Tmem45b biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
intracellular signal transductionGO:00355563140.227
positive regulation of cellular biosynthetic processGO:00313282950.219
cellular response to hormone stimulusGO:00328702470.194
single organism biosynthetic processGO:00447113420.169
chemical homeostasisGO:00488782920.169
regulation of molecular functionGO:00650093980.167
apoptotic processGO:00069153810.134
cellular calcium ion homeostasisGO:00068741600.126
positive regulation of nucleobase containing compound metabolic processGO:00459353190.126
programmed cell deathGO:00125013920.110
positive regulation of gene expressionGO:00106282440.109
response to extracellular stimulusGO:00099913800.106
single organism reproductive processGO:00447022970.105
regulation of programmed cell deathGO:00430673410.104
divalent inorganic cation homeostasisGO:00725071650.102
response to inorganic substanceGO:00100353770.102
head developmentGO:00603222470.101
defense responseGO:00069521940.096
negative regulation of cell deathGO:00605482290.092
tissue developmentGO:00098882520.091
response to glucocorticoidGO:00513842230.091
response to peptide hormoneGO:00434342780.090
regulation of apoptotic processGO:00429813350.088
positive regulation of nucleic acid templated transcriptionGO:19035081970.088
neurological system processGO:00508772190.087
cellular component movementGO:00069282480.087
positive regulation of nitrogen compound metabolic processGO:00511733340.086
cellular component biogenesisGO:00440853680.086
single organism carbohydrate metabolic processGO:00447231180.085
negative regulation of cellular metabolic processGO:00313242810.085
ion transmembrane transportGO:00342203650.084
response to nutrient levelsGO:00316673700.082
regulation of rna biosynthetic processGO:20011413810.082
cellular response to endogenous stimulusGO:00714953770.081
cellular chemical homeostasisGO:00550822470.079
cellular response to oxygen containing compoundGO:19017013860.077
positive regulation of molecular functionGO:00440932300.077
protein phosphorylationGO:00064683450.076
negative regulation of molecular functionGO:00440921330.075
cell projection organizationGO:00300303020.075
response to nutrientGO:00075842480.075
actin filament based processGO:0030029860.074
organophosphate metabolic processGO:00196373700.074
cellular ion homeostasisGO:00068731840.074
negative regulation of programmed cell deathGO:00430691830.074
carbohydrate derivative metabolic processGO:19011353460.073
cellular metal ion homeostasisGO:00068751720.072
regulation of signal transductionGO:00099663180.072
carbohydrate metabolic processGO:00059751300.072
negative regulation of apoptotic processGO:00430661810.072
regulation of cellular protein metabolic processGO:00322682670.069
central nervous system developmentGO:00074173110.067
homeostatic processGO:00425923310.067
negative regulation of macromolecule metabolic processGO:00106052600.064
response to hexoseGO:00097461440.064
cell type specific apoptotic processGO:00972851340.064
negative regulation of metabolic processGO:00098923310.063
positive regulation of biosynthetic processGO:00098913190.063
regulation of hormone levelsGO:00108171870.062
sensory perceptionGO:00076001010.061
regulation of phosphorylationGO:00423252480.060
reproductionGO:00000032450.058
positive regulation of rna biosynthetic processGO:19026801970.058
monovalent inorganic cation transportGO:00156721720.057
regulation of secretionGO:00510462240.057
macromolecule localizationGO:00330362520.056
cellular response to organic cyclic compoundGO:00714072020.055
regulation of cell differentiationGO:00455953200.055
calcium ion homeostasisGO:00550741620.055
cellular response to peptideGO:19016531330.055
regulation of cell proliferationGO:00421273590.054
organelle organizationGO:00069962660.054
inorganic cation transmembrane transportGO:00986622020.053
brain developmentGO:00074202470.053
reproductive processGO:00224143720.052
developmental process involved in reproductionGO:00030061590.052
regulation of cellular component organizationGO:00511283680.051
cellular homeostasisGO:00197252520.051
catabolic processGO:00090563510.051
enzyme linked receptor protein signaling pathwayGO:00071671160.051
negative regulation of biosynthetic processGO:00098901680.051
regulation of cellular component movementGO:00512701500.050
regulation of catalytic activityGO:00507903040.050
inorganic ion transmembrane transportGO:00986602290.049
neuron developmentGO:00486662860.049
cytosolic calcium ion homeostasisGO:00514801400.048
cation homeostasisGO:00550801950.048
forebrain developmentGO:0030900980.048
negative regulation of cellular biosynthetic processGO:00313271610.047
positive regulation of cytosolic calcium ion concentrationGO:00072041220.047
transcription dna templatedGO:00063513770.047
response to monosaccharideGO:00342841590.046
positive regulation of cell proliferationGO:00082842490.046
response to carbohydrateGO:00097431830.046
negative regulation of signalingGO:00230571570.046
response to oxidative stressGO:00069791860.046
cellular response to cytokine stimulusGO:00713451270.045
positive regulation of macromolecule biosynthetic processGO:00105572470.045
inflammatory responseGO:00069541500.045
response to acid chemicalGO:00011012220.044
response to woundingGO:00096112540.044
blood circulationGO:00080151830.043
rhythmic processGO:00485111560.043
ion homeostasisGO:00508012120.042
organonitrogen compound biosynthetic processGO:19015661670.042
positive regulation of hormone secretionGO:0046887650.041
metal ion homeostasisGO:00550651860.041
positive regulation of transcription dna templatedGO:00458931970.041
phospholipase c activating g protein coupled receptor signaling pathwayGO:0007200270.040
organic hydroxy compound metabolic processGO:19016151150.040
organic acid metabolic processGO:00060822920.040
anion transportGO:00068201780.040
positive regulation of rna metabolic processGO:00512542030.040
cell migrationGO:00164771970.040
regulation of phosphate metabolic processGO:00192203490.040
regulation of protein modification processGO:00313991940.039
regulation of protein phosphorylationGO:00019321830.039
ribose phosphate metabolic processGO:00196932350.039
lipid metabolic processGO:00066292830.038
positive regulation of phosphorus metabolic processGO:00105622620.038
cellular divalent inorganic cation homeostasisGO:00725031620.038
response to glucoseGO:00097491360.037
lipid biosynthetic processGO:00086101280.037
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.037
proteolysisGO:00065081750.037
regulation of phosphorus metabolic processGO:00511743490.037
positive regulation of multicellular organismal processGO:00512403870.037
anatomical structure morphogenesisGO:00096532980.037
response to ketoneGO:19016541820.036
regenerationGO:00310991630.036
negative regulation of gene expressionGO:00106291990.036
sensory perception of painGO:0019233730.036
reproductive system developmentGO:00614581280.036
immune responseGO:00069551040.036
multi organism reproductive processGO:00447032620.036
alcohol metabolic processGO:0006066770.035
response to decreased oxygen levelsGO:00362932370.035
nucleobase containing small molecule metabolic processGO:00550863160.035
oxoacid metabolic processGO:00434362900.035
cellular response to tumor necrosis factorGO:0071356460.035
negative regulation of nitrogen compound metabolic processGO:00511721610.035
secretion by cellGO:00329402480.035
response to oxygen levelsGO:00704822650.035
response to estrogenGO:00436272320.035
positive regulation of phosphate metabolic processGO:00459372620.035
response to hypoxiaGO:00016662310.035
cell motilityGO:00488702020.035
cellular amine metabolic processGO:0044106380.034
negative regulation of cell communicationGO:00106481580.034
cellular response to steroid hormone stimulusGO:0071383930.034
cellular ketone metabolic processGO:0042180510.034
nucleotide metabolic processGO:00091172790.034
positive regulation of developmental processGO:00510942830.033
macromolecular complex subunit organizationGO:00439333390.033
response to purine containing compoundGO:00140741260.033
regulation of nucleic acid templated transcriptionGO:19035063800.032
cellular component morphogenesisGO:00329891550.032
regulation of multicellular organismal developmentGO:20000263760.032
regulation of rna metabolic processGO:00512523910.032
multicellular organismal reproductive processGO:00486092330.032
negative regulation of transportGO:00510511360.032
cellular carbohydrate metabolic processGO:0044262720.032
sexual reproductionGO:00199531480.032
positive regulation of cell motilityGO:2000147970.032
regulation of metal ion transportGO:00109591180.032
response to estradiolGO:00323551640.032
regulation of membrane potentialGO:00423911100.031
response to radiationGO:00093141370.031
cell cell signalingGO:00072673350.031
hormone secretionGO:00468791150.031
response to tumor necrosis factorGO:0034612560.031
negative regulation of nucleobase containing compound metabolic processGO:00459341530.031
response to peptideGO:19016522920.030
growthGO:00400071650.030
rna metabolic processGO:00160704060.030
localization of cellGO:00516742020.030
transcription from rna polymerase ii promoterGO:00063662520.030
regulation of cell developmentGO:00602842630.029
regulation of immunoglobulin secretionGO:005102310.029
cellular response to lipidGO:00713962010.029
cyclic nucleotide metabolic processGO:0009187800.029
muscle cell proliferationGO:0033002840.029
amine metabolic processGO:0009308380.029
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.029
epithelium developmentGO:0060429960.029
protein localizationGO:00081041910.029
positive regulation of apoptotic processGO:00430651540.029
ossificationGO:0001503700.028
neuron projection developmentGO:00311752730.028
organophosphate biosynthetic processGO:00904071430.028
positive regulation of phosphorylationGO:00423271770.028
jak stat cascadeGO:0007259260.027
positive regulation of signalingGO:00230562700.027
regulation of purine nucleotide metabolic processGO:19005421150.027
agingGO:00075682410.027
regulation of smooth muscle cell proliferationGO:0048660750.027
development of primary sexual characteristicsGO:00451371070.027
carboxylic acid metabolic processGO:00197522890.027
cation transmembrane transportGO:00986552630.027
regulation of hormone secretionGO:00468831060.027
positive regulation of response to stimulusGO:00485842850.027
intracellular transportGO:00469071850.027
cellular response to organonitrogen compoundGO:00714171970.026
regulation of kinase activityGO:00435491170.026
nucleoside phosphate metabolic processGO:00067532830.026
negative regulation of response to stimulusGO:00485851550.026
heart processGO:0003015570.026
regulation of cellular ketone metabolic processGO:0010565270.026
response to hydrogen peroxideGO:0042542890.026
response to metal ionGO:00100382530.026
response to alkaloidGO:00432791320.026
regulation of cell migrationGO:00303341280.025
multicellular organismal signalingGO:0035637440.025
regulation of cellular amine metabolic processGO:003323880.025
neuron differentiationGO:00301823680.025
regulation of transferase activityGO:00513381230.025
multicellular organism reproductionGO:00325042330.025
single organismal cell cell adhesionGO:0016337420.025
organic substance catabolic processGO:19015753160.025
positive regulation of catalytic activityGO:00430851840.024
regulation of saliva secretionGO:004687730.024
calcium ion transportGO:00068161310.024
cellular component assemblyGO:00226073600.024
carbohydrate derivative biosynthetic processGO:19011371240.024
regulation of blood circulationGO:19035221100.024
cellular response to peptide hormone stimulusGO:00713751200.024
regulation of neuron deathGO:19012141150.024
positive regulation of secretionGO:00510471400.023
cellular response to nitrogen compoundGO:19016992100.023
small molecule biosynthetic processGO:00442831240.023
purine nucleotide metabolic processGO:00061632290.023
response to corticosteroidGO:00319602350.023
response to cytokineGO:00340972150.023
regulation of ion transmembrane transportGO:00347651210.023
heart contractionGO:0060047570.023
regulation of protein metabolic processGO:00512462890.023
negative regulation of developmental processGO:00510931250.023
gland developmentGO:00487321550.023
muscle structure developmentGO:0061061870.023
regulation of transcription dna templatedGO:00063553740.023
purine ribonucleotide metabolic processGO:00091502270.023
positive regulation of transportGO:00510502450.023
negative regulation of nucleic acid templated transcriptionGO:19035071170.023
response to bacteriumGO:00096172000.023
response to reactive oxygen speciesGO:00003021200.022
regulation of ion transportGO:00432692450.022
circulatory system processGO:00030131830.022
response to organophosphorusGO:00466831020.022
peptide hormone secretionGO:0030072840.022
regulation of cellular amino acid metabolic processGO:000652120.022
regulation of system processGO:00440572080.022
meiotic cell cycle processGO:190304630.022
regulation of blood vessel sizeGO:0050880890.022
response to insulinGO:00328681330.022
positive regulation of peptide hormone secretionGO:0090277500.022
positive regulation of cell differentiationGO:00455972170.022
cell adhesionGO:00071551100.021
transmembrane transportGO:00550854120.021
purine ribonucleoside metabolic processGO:00461281680.021
dna metabolic processGO:0006259960.021
sex differentiationGO:00075481130.021
rna biosynthetic processGO:00327743800.021
positive regulation of cell deathGO:00109421840.021
neuron deathGO:00709971270.021
locomotionGO:00400112370.021
response to molecule of bacterial originGO:00022371940.021
regulation of hydrolase activityGO:00513361430.021
kidney developmentGO:0001822670.020
regulation of body fluid levelsGO:0050878900.020
regulation of insulin secretionGO:0050796650.020
gamete generationGO:00072761240.020
nitrogen compound transportGO:00717052290.020
positive regulation of protein metabolic processGO:00512471780.019
regulation of peptide transportGO:0090087870.019
positive regulation of signal transductionGO:00099671750.019
small gtpase mediated signal transductionGO:0007264360.019
positive regulation of cellular protein metabolic processGO:00322701670.019
urogenital system developmentGO:0001655780.019
peptidyl amino acid modificationGO:00181931260.019
cation transportGO:00068123820.019
behaviorGO:00076102050.019
generation of precursor metabolites and energyGO:0006091620.019
protein complex subunit organizationGO:00718223020.019
lipid transportGO:0006869610.019
chemotaxisGO:0006935660.019
neuron apoptotic processGO:0051402880.019
negative regulation of protein metabolic processGO:00512481140.019
reactive oxygen species metabolic processGO:0072593370.018
cell morphogenesisGO:00009021420.018
actin cytoskeleton organizationGO:0030036730.018
positive regulation of secretion by cellGO:19035321280.018
positive regulation of programmed cell deathGO:00430681570.018
organ regenerationGO:00311001010.018
nucleoside phosphate biosynthetic processGO:19012931020.018
reproductive structure developmentGO:00486081280.018
biological adhesionGO:00226101100.018
glycosyl compound metabolic processGO:19016571820.017
regulation of locomotionGO:00400121480.017
nucleotide catabolic processGO:00091661390.017
response to osmotic stressGO:0006970420.017
detection of chemical stimulus involved in sensory perception of bitter tasteGO:000158040.017
cellular nitrogen compound catabolic processGO:00442701630.017
single organism intracellular transportGO:19025821660.017
spermatogenesisGO:0007283990.017
regulation of immunoglobulin productionGO:000263740.017
negative regulation of rna biosynthetic processGO:19026791180.017
cellular catabolic processGO:00442482950.017
immune system processGO:00023762040.017
establishment of protein localizationGO:00451841410.017
energy reserve metabolic processGO:0006112250.017
energy derivation by oxidation of organic compoundsGO:0015980460.017
positive regulation of intracellular signal transductionGO:19025331380.017
regulation of secretion by cellGO:19035302080.017
secretionGO:00469033070.017
ras protein signal transductionGO:0007265290.016
regulation of cell projection organizationGO:00313441750.016
cytoskeleton organizationGO:00070101110.016
protein processingGO:0016485680.016
regulation of neurological system processGO:0031644430.016
regulation of neuron apoptotic processGO:0043523830.016
neuronal action potentialGO:0019228350.016
signal releaseGO:00230611450.016
protein complex biogenesisGO:00702712630.016
regulation of nervous system developmentGO:00519602640.016
regulation of behaviorGO:0050795610.016
regulation of response to stressGO:00801341260.016
regulation of neuron differentiationGO:00456642080.016
divalent inorganic cation transportGO:00725111340.016
regulation of transmembrane transporter activityGO:0022898490.016
neuron projection morphogenesisGO:00488121220.016
oxidation reduction processGO:00551143040.016
regulation of peptide hormone secretionGO:0090276800.016
metal ion transportGO:00300012890.016
regulation of cellular localizationGO:00603412630.016
cell projection morphogenesisGO:00488581230.016
regulation of intracellular signal transductionGO:19025312180.016
positive regulation of protein modification processGO:00314011420.015
regulation of cell motilityGO:20001451310.015
regulation of anatomical structure morphogenesisGO:00226031410.015
cell growthGO:00160491040.015
negative regulation of macromolecule biosynthetic processGO:00105581480.015
regulation of purine nucleotide biosynthetic processGO:1900371460.015
muscle contractionGO:0006936880.015
sensory perception of bitter tasteGO:005091340.015
cellular response to insulin stimulusGO:0032869810.015
regulation of nucleotide metabolic processGO:00061401170.015
male gamete generationGO:0048232990.015
single organism behaviorGO:00447081300.015
cell part morphogenesisGO:00329901230.015
negative regulation of signal transductionGO:0009968830.015
cardiac conductionGO:006133720.015
negative regulation of cell differentiationGO:0045596990.015
positive regulation of kinase activityGO:0033674770.015
dna replicationGO:0006260370.015
positive regulation of peptide secretionGO:0002793520.015
response to external biotic stimulusGO:00432072210.015
nucleoside metabolic processGO:00091161790.015
molting cycleGO:004230330.015
epithelial cell differentiationGO:0030855710.015
immunoglobulin secretionGO:004830510.015
single organism organelle organizationGO:19025891800.014
sensory organ developmentGO:0007423740.014
negative regulation of neuron deathGO:1901215690.014
immune effector processGO:0002252530.014
sodium ion transportGO:0006814820.014
ribonucleoside monophosphate metabolic processGO:0009161880.014
cellular response to corticosteroid stimulusGO:0071384690.014
purine containing compound catabolic processGO:00725231380.014
positive regulation of cellular amine metabolic processGO:003324030.014
positive regulation of cell communicationGO:00106472710.014
regulation of g0 to g1 transitionGO:007031630.014
regulation of response to woundingGO:1903034690.014
cell activationGO:0001775970.014
circadian regulation of gene expressionGO:003292230.014
regulation of tube sizeGO:0035150890.014
response to axon injuryGO:0048678590.014
smooth muscle cell proliferationGO:0048659770.014
male sex differentiationGO:0046661640.014
negative regulation of secretionGO:0051048820.014
renal system developmentGO:0072001670.014
response to ionizing radiationGO:0010212590.013
organic acid biosynthetic processGO:0016053830.013
female pregnancyGO:00075651220.013
regulation of defense responseGO:0031347680.013
monocarboxylic acid metabolic processGO:00327871520.013
cardiovascular system developmentGO:00723581340.013
response to calcium ionGO:0051592590.013
response to mineralocorticoidGO:0051385490.013
regulation of cyclic nucleotide biosynthetic processGO:0030802450.013
cyclic nucleotide biosynthetic processGO:0009190630.013
negative regulation of secretion by cellGO:1903531720.013
regulation of transporter activityGO:0032409500.013
hair cycleGO:004263330.013
muscle system processGO:00030121150.013
positive regulation of camp biosynthetic processGO:0030819280.013
carbohydrate derivative catabolic processGO:19011361470.013
regulation of lipid metabolic processGO:0019216680.013
regulation of carbohydrate metabolic processGO:0006109410.013
membrane organizationGO:0061024940.013
nucleobase containing compound catabolic processGO:00346551520.013
calcium ion transmembrane transportGO:0070588700.013
response to biotic stimulusGO:00096072260.013
response to lipopolysaccharideGO:00324961910.013
organic hydroxy compound biosynthetic processGO:1901617510.013
regulation of cellular carbohydrate metabolic processGO:0010675390.013
heterocycle catabolic processGO:00467001670.013
organic acid transportGO:00158491160.013
purine containing compound biosynthetic processGO:0072522850.013
axis specificationGO:000979840.013
negative regulation of cellular protein metabolic processGO:00322691060.013
response to light stimulusGO:0009416520.013
regulation of protein localizationGO:0032880810.013
purine containing compound metabolic processGO:00725212530.012
negative regulation of peptide hormone secretionGO:0090278300.012
monocarboxylic acid transportGO:0015718520.012
cellular glucose homeostasisGO:0001678660.012
regulation of homotypic cell cell adhesionGO:003411040.012
ribonucleotide metabolic processGO:00092592310.012
cellular amino acid metabolic processGO:00065201070.012
positive regulation of locomotionGO:00400171020.012
regulation of protein kinase activityGO:00458591050.012
response to transforming growth factor betaGO:0071559460.012
epibolyGO:009050420.012
response to nicotineGO:0035094510.012
purine nucleoside metabolic processGO:00422781690.012
ovulation cycle processGO:0022602500.012
cellular cation homeostasisGO:00300031800.012
protein complex assemblyGO:00064612630.012
macromolecular complex assemblyGO:00650032730.012
negative regulation of phosphorus metabolic processGO:0010563800.012
negative regulation of rna metabolic processGO:00512531230.012
protein maturationGO:0051604680.012
cell communication involved in cardiac conductionGO:008606520.012
cellular response to growth factor stimulusGO:00713631620.012
rho protein signal transductionGO:0007266110.012
nucleic acid templated transcriptionGO:00976593790.012
vascular process in circulatory systemGO:0003018960.012
fatty acid derivative biosynthetic processGO:1901570180.012
cell morphogenesis involved in differentiationGO:00009041190.012
positive regulation of blood circulationGO:1903524650.012
regulation of cyclic nucleotide metabolic processGO:0030799510.012
male mating behaviorGO:006017930.012
negative regulation of catalytic activityGO:00430861030.011
carboxylic acid transportGO:00469421150.011
regulation of reactive oxygen species metabolic processGO:2000377260.011
carbohydrate biosynthetic processGO:0016051420.011
regulation of peptide secretionGO:0002791820.011
action potentialGO:0001508540.011
cognitionGO:0050890920.011
response to vitaminGO:00332731310.011
regulation of neuron projection developmentGO:00109751610.011
organic anion transportGO:00157111320.011
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188510.011
response to ethanolGO:00454711620.011
cellular response to abiotic stimulusGO:0071214850.011
regulation of muscle system processGO:0090257790.011
regulation of jak stat cascadeGO:0046425210.011
negative regulation of cell proliferationGO:00082851190.011
positive regulation of transferase activityGO:0051347810.011
regulation of phagocytosis engulfmentGO:006009940.011
regulation of inflammatory responseGO:0050727480.011
cell cell signaling involved in cell fate commitmentGO:004516820.011
regulation of blood pressureGO:0008217830.011
odontogenesisGO:0042476320.011
hormone transportGO:00099141210.011
salivary gland developmentGO:000743130.011
cellular response to stressGO:00335542690.011
negative regulation of cardiac muscle tissue developmentGO:005502630.011
response to activityGO:0014823730.011
chromosome segregationGO:000705920.011
fatty acid derivative metabolic processGO:1901568380.011
positive regulation of digestive system processGO:006045680.011
wound healingGO:00420601220.011
ribose phosphate biosynthetic processGO:0046390870.011
purine nucleotide catabolic processGO:00061951360.011
organic cyclic compound catabolic processGO:19013611750.011
negative regulation of cellular component organizationGO:0051129830.011
regulation of calcium ion transportGO:0051924770.011
divalent metal ion transportGO:00708381320.011
negative regulation of phosphate metabolic processGO:0045936800.011
regulation of response to external stimulusGO:00321011060.011
regulation of cell growthGO:0001558850.011
regulation of cell morphogenesis involved in differentiationGO:0010769720.011
cellular response to glucocorticoid stimulusGO:0071385680.011
insulin secretionGO:0030073690.011
lipid localizationGO:0010876620.011

Tmem45b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
renal tubular transport diseaseDOID:44700.039
disease of anatomical entityDOID:700.039
kidney diseaseDOID:55700.039
urinary system diseaseDOID:1800.039
integumentary system diseaseDOID:1600.016
musculoskeletal system diseaseDOID:1700.014
nervous system diseaseDOID:86300.013
sensory system diseaseDOID:005015500.013
overnutritionDOID:65400.011
acquired metabolic diseaseDOID:006015800.011
nutrition diseaseDOID:37400.011
disease of metabolismDOID:001466700.011