IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Fgf22

fibroblast growth factor 22

Entrez: 170579
Ensembl: ENSRNOG00000008960
RGD: 620177
UniProtKB: Q8VI79

Process Predictions
Disease Predictions

Fgf22 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of multicellular organismal development	GO:2000026	376	0.176	Rat
regulation of neurogenesis	GO:0050767	247	0.156
regulation of ossification	GO:0030278	32	0.126
regulation of cell differentiation	GO:0045595	320	0.116
motor neuron axon guidance	GO:0008045	1	0.102
regulation of nervous system development	GO:0051960	264	0.091
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.089
cellular component assembly	GO:0022607	360	0.087
head development	GO:0060322	247	0.087
regulation of cell development	GO:0060284	263	0.083
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.078
nucleotide metabolic process	GO:0009117	279	0.077
negative regulation of developmental process	GO:0051093	125	0.077
cell morphogenesis involved in differentiation	GO:0000904	119	0.071
organophosphate metabolic process	GO:0019637	370	0.071	Rat
phasic smooth muscle contraction	GO:0014821	3	0.070
anatomical structure morphogenesis	GO:0009653	298	0.068	Rat
negative regulation of nervous system development	GO:0051961	79	0.065
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.063
membrane organization	GO:0061024	94	0.062
positive regulation of nervous system development	GO:0051962	178	0.062
central nervous system development	GO:0007417	311	0.058
neurological system process	GO:0050877	219	0.058
axon development	GO:0061564	96	0.057
intracellular signal transduction	GO:0035556	314	0.057	Rat
inorganic cation transmembrane transport	GO:0098662	202	0.057	Rat
negative regulation of rna metabolic process	GO:0051253	123	0.056
positive regulation of cell differentiation	GO:0045597	217	0.056
cellular component biogenesis	GO:0044085	368	0.054
negative regulation of transcription dna templated	GO:0045892	116	0.053
transcription from rna polymerase ii promoter	GO:0006366	252	0.053
negative regulation of rna biosynthetic process	GO:1902679	118	0.053
neuron development	GO:0048666	286	0.053
regulation of saliva secretion	GO:0046877	3	0.052
negative regulation of cell differentiation	GO:0045596	99	0.052
regulation of membrane potential	GO:0042391	110	0.051	Rat
ribose phosphate metabolic process	GO:0019693	235	0.049
negative regulation of cell development	GO:0010721	82	0.048
regulation of axonogenesis	GO:0050770	37	0.048
regulation of the force of heart contraction by chemical signal	GO:0003057	2	0.046
transcription dna templated	GO:0006351	377	0.046
neuron differentiation	GO:0030182	368	0.045
response to mechanical stimulus	GO:0009612	134	0.045
renal system development	GO:0072001	67	0.045
response to estradiol	GO:0032355	164	0.045	Rat
negative regulation of neuron differentiation	GO:0045665	62	0.044
regulation of secretion by cell	GO:1903530	208	0.044
mechanoreceptor differentiation	GO:0042490	2	0.044
action potential	GO:0001508	54	0.043
regulation of neuron projection development	GO:0010975	161	0.043
urogenital system development	GO:0001655	78	0.042
positive regulation of multicellular organismal process	GO:0051240	387	0.042	Rat
kidney development	GO:0001822	67	0.042
synaptic transmission	GO:0007268	235	0.041
positive regulation of developmental process	GO:0051094	283	0.041	Rat
synapse organization	GO:0050808	46	0.041
negative regulation of multicellular organismal process	GO:0051241	203	0.041
sensory perception	GO:0007600	101	0.040
brain development	GO:0007420	247	0.039
nucleoside phosphate metabolic process	GO:0006753	283	0.039
regulation of transcription dna templated	GO:0006355	374	0.039
growth	GO:0040007	165	0.037	Rat
nucleobase containing small molecule metabolic process	GO:0055086	316	0.037
cellular component morphogenesis	GO:0032989	155	0.036
regulation of hormone levels	GO:0010817	187	0.035
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.035
regulation of neuron differentiation	GO:0045664	208	0.035
secretion	GO:0046903	307	0.035
ion transmembrane transport	GO:0034220	365	0.034	Rat
purine ribonucleotide metabolic process	GO:0009150	227	0.034
organelle organization	GO:0006996	266	0.032
negative regulation of neurogenesis	GO:0050768	78	0.032
nucleoside triphosphate metabolic process	GO:0009141	144	0.032
regulation of cell morphogenesis	GO:0022604	77	0.032
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.032
single organism reproductive process	GO:0044702	297	0.031	Rat
palate development	GO:0060021	2	0.031
protein oligomerization	GO:0051259	191	0.031
regulation of rna biosynthetic process	GO:2001141	381	0.030
regulation of anatomical structure morphogenesis	GO:0022603	141	0.030	Rat
organic anion transport	GO:0015711	132	0.030
sensory organ development	GO:0007423	74	0.029
secretion by cell	GO:0032940	248	0.029
single organism membrane organization	GO:0044802	74	0.029
regulation of systemic arterial blood pressure by norepinephrine epinephrine	GO:0001993	2	0.029
positive regulation of neurogenesis	GO:0050769	165	0.029
cell part morphogenesis	GO:0032990	123	0.029
positive regulation of protein phosphorylation	GO:0001934	135	0.029
protein complex biogenesis	GO:0070271	263	0.028
macromolecular complex subunit organization	GO:0043933	339	0.028
transmembrane transport	GO:0055085	412	0.028	Rat
purine nucleoside catabolic process	GO:0006152	124	0.028
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.028
potassium ion transport	GO:0006813	97	0.028
protein phosphorylation	GO:0006468	345	0.027
glutamate receptor signaling pathway	GO:0007215	43	0.027
sodium ion transport	GO:0006814	82	0.027	Rat
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.027
purine nucleotide metabolic process	GO:0006163	229	0.027
inorganic ion transmembrane transport	GO:0098660	229	0.027	Rat
nucleic acid templated transcription	GO:0097659	379	0.027
regulation of nucleic acid templated transcription	GO:1903506	380	0.027
regulation of cell projection organization	GO:0031344	175	0.026
tissue development	GO:0009888	252	0.026	Rat
response to temperature stimulus	GO:0009266	94	0.025
organ regeneration	GO:0031100	101	0.025
positive regulation of biosynthetic process	GO:0009891	319	0.025
single organism behavior	GO:0044708	130	0.025
limb morphogenesis	GO:0035108	4	0.025
regulation of ion transport	GO:0043269	245	0.025	Rat
organic cyclic compound catabolic process	GO:1901361	175	0.025
glomerulus development	GO:0032835	10	0.025
organonitrogen compound biosynthetic process	GO:1901566	167	0.025	Rat
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.025
protein localization	GO:0008104	191	0.025
dendrite development	GO:0016358	72	0.024
adult locomotory behavior	GO:0008344	4	0.024
urinary bladder smooth muscle contraction	GO:0014832	4	0.024
urinary tract smooth muscle contraction	GO:0014848	4	0.024
organonitrogen compound catabolic process	GO:1901565	179	0.024
signal release	GO:0023061	145	0.024
purine ribonucleoside monophosphate catabolic process	GO:0009169	55	0.024
carbohydrate derivative metabolic process	GO:1901135	346	0.023
neuromuscular process	GO:0050905	2	0.023
dorsal ventral axon guidance	GO:0033563	1	0.023
cellular ion homeostasis	GO:0006873	184	0.022
response to amino acid	GO:0043200	75	0.022
embryonic appendage morphogenesis	GO:0035113	4	0.022
positive regulation of cellular biosynthetic process	GO:0031328	295	0.022
tube development	GO:0035295	89	0.022	Rat
response to retinoic acid	GO:0032526	63	0.022
cell projection organization	GO:0030030	302	0.022
purine nucleotide catabolic process	GO:0006195	136	0.022
positive regulation of cell development	GO:0010720	176	0.021
nucleotide catabolic process	GO:0009166	139	0.021
regulation of nucleotide metabolic process	GO:0006140	117	0.021
purine ribonucleotide catabolic process	GO:0009154	136	0.021
gland development	GO:0048732	155	0.021
ribonucleotide metabolic process	GO:0009259	231	0.020
cellular catabolic process	GO:0044248	295	0.020
cell morphogenesis	GO:0000902	142	0.020
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.020
ion homeostasis	GO:0050801	212	0.020	Rat
developmental growth involved in morphogenesis	GO:0060560	33	0.020
skeletal system development	GO:0001501	41	0.020
negative regulation of macromolecule metabolic process	GO:0010605	260	0.020
protein complex subunit organization	GO:0071822	302	0.020
positive regulation of cellular component organization	GO:0051130	200	0.020
organophosphate catabolic process	GO:0046434	148	0.020
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.020
carbohydrate derivative catabolic process	GO:1901136	147	0.020
response to oxidative stress	GO:0006979	186	0.019
positive regulation of phosphate metabolic process	GO:0045937	262	0.019	Rat
cell growth	GO:0016049	104	0.019
positive regulation of long term synaptic potentiation	GO:1900273	4	0.019
axonogenesis	GO:0007409	71	0.019
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.019
neural precursor cell proliferation	GO:0061351	23	0.019
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.019
positive regulation of programmed cell death	GO:0043068	157	0.019
single organism organelle organization	GO:1902589	180	0.019
lymphoid progenitor cell differentiation	GO:0002320	2	0.019
positive regulation of rna metabolic process	GO:0051254	203	0.019
glycosyl compound catabolic process	GO:1901658	126	0.018
macromolecule localization	GO:0033036	252	0.018
negative regulation of biosynthetic process	GO:0009890	168	0.018
positive regulation of transferase activity	GO:0051347	81	0.018
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.018
axis specification	GO:0009798	4	0.018
anterior posterior pattern specification	GO:0009952	1	0.018
forebrain development	GO:0030900	98	0.017
gastrulation	GO:0007369	2	0.017
lipid metabolic process	GO:0006629	283	0.017	Rat
mesoderm development	GO:0007498	2	0.017
nucleoside triphosphate catabolic process	GO:0009143	123	0.017
regulation of phosphatidylinositol dephosphorylation	GO:0060304	1	0.017
nucleoside metabolic process	GO:0009116	179	0.017
peptide hormone secretion	GO:0030072	84	0.017
aging	GO:0007568	241	0.017	Rat
cell fate determination	GO:0001709	2	0.017
detection of stimulus	GO:0051606	24	0.017
heart morphogenesis	GO:0003007	3	0.017
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.017
forebrain neuron development	GO:0021884	3	0.017
positive regulation of saliva secretion	GO:0046878	3	0.017
regulation of dendrite development	GO:0050773	59	0.017
positive regulation of action potential	GO:0045760	8	0.017
gliogenesis	GO:0042063	93	0.016
forebrain generation of neurons	GO:0021872	8	0.016
phospholipid metabolic process	GO:0006644	61	0.016	Rat
positive regulation of phosphorus metabolic process	GO:0010562	262	0.016	Rat
regulation of protein localization	GO:0032880	81	0.016
cardiovascular system development	GO:0072358	134	0.016	Rat
carbohydrate derivative biosynthetic process	GO:1901137	124	0.016
regulation of synaptic transmission	GO:0050804	141	0.016
cellular amine metabolic process	GO:0044106	38	0.016	Rat
insulin secretion	GO:0030073	69	0.016
behavior	GO:0007610	205	0.016
regulation of signal transduction	GO:0009966	318	0.015	Rat
regulation of protein modification process	GO:0031399	194	0.015
rho protein signal transduction	GO:0007266	11	0.015
response to food	GO:0032094	27	0.015
negative regulation of transport	GO:0051051	136	0.015	Rat
nucleoside phosphate catabolic process	GO:1901292	140	0.015
regulation of organelle organization	GO:0033043	80	0.015
salivary gland development	GO:0007431	3	0.015
multi organism reproductive process	GO:0044703	262	0.015
positive regulation of molecular function	GO:0044093	230	0.015
neuron projection guidance	GO:0097485	24	0.015
neuron projection development	GO:0031175	273	0.015
positive regulation of phosphorylation	GO:0042327	177	0.015	Rat
circulatory system process	GO:0003013	183	0.015
ras protein signal transduction	GO:0007265	29	0.015
myelination	GO:0042552	39	0.015
negative regulation of uterine smooth muscle contraction	GO:0070473	2	0.015
cellular cation homeostasis	GO:0030003	180	0.015
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	41	0.014
negative regulation of response to stimulus	GO:0048585	155	0.014
protein complex assembly	GO:0006461	263	0.014
anion transport	GO:0006820	178	0.014
regulation of protein kinase activity	GO:0045859	105	0.014
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.014
regulation of cellular component organization	GO:0051128	368	0.014
exocytosis	GO:0006887	60	0.014
regulation of cytoskeleton organization	GO:0051493	49	0.014
heterocycle catabolic process	GO:0046700	167	0.014
metanephric tubule morphogenesis	GO:0072173	2	0.014
cellular component movement	GO:0006928	248	0.014
nucleoside phosphate biosynthetic process	GO:1901293	102	0.014
rna biosynthetic process	GO:0032774	380	0.014
nucleobase containing compound catabolic process	GO:0034655	152	0.014
negative regulation of metabolic process	GO:0009892	331	0.014
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.014
negative regulation of signaling	GO:0023057	157	0.013
response to toxic substance	GO:0009636	133	0.013
regulation of axon extension	GO:0030516	24	0.013
organic substance catabolic process	GO:1901575	316	0.013
regulation of rna metabolic process	GO:0051252	391	0.013
macromolecular complex assembly	GO:0065003	273	0.013
purine nucleoside metabolic process	GO:0042278	169	0.013
positive regulation of protein modification process	GO:0031401	142	0.013
negative regulation of cellular biosynthetic process	GO:0031327	161	0.013
neuron projection morphogenesis	GO:0048812	122	0.013
ossification	GO:0001503	70	0.013
nucleoside catabolic process	GO:0009164	126	0.013
metal ion transport	GO:0030001	289	0.013	Rat
response to lipopolysaccharide	GO:0032496	191	0.013	Rat
purine ribonucleoside catabolic process	GO:0046130	124	0.013
embryonic skeletal system morphogenesis	GO:0048704	3	0.013
reproductive process	GO:0022414	372	0.013	Rat
purine nucleoside monophosphate catabolic process	GO:0009128	55	0.013
negative regulation of gene expression	GO:0010629	199	0.013
neurotransmitter secretion	GO:0007269	33	0.013
aromatic compound catabolic process	GO:0019439	168	0.013
positive regulation of the force of heart contraction by norepinephrine	GO:0003061	1	0.013
reproduction	GO:0000003	245	0.013	Rat
monovalent inorganic cation transport	GO:0015672	172	0.013	Rat
atp catabolic process	GO:0006200	54	0.013
regulation of neurotransmitter levels	GO:0001505	42	0.013
regulation of cellular amino acid metabolic process	GO:0006521	2	0.013
endoplasmic reticulum organization	GO:0007029	1	0.013
regulation of catalytic activity	GO:0050790	304	0.012
neuronal stem cell maintenance	GO:0097150	2	0.012
positive regulation of catalytic activity	GO:0043085	184	0.012
detection of chemical stimulus involved in sensory perception of bitter taste	GO:0001580	4	0.012
ear development	GO:0043583	21	0.012
cellular response to growth factor stimulus	GO:0071363	162	0.012	Rat
ribonucleoside metabolic process	GO:0009119	174	0.012
axon guidance	GO:0007411	24	0.012
divalent metal ion transport	GO:0070838	132	0.012
apoptotic process	GO:0006915	381	0.012
cardiac chamber development	GO:0003205	1	0.012
regulation of extent of cell growth	GO:0061387	25	0.012
regulation of purine nucleotide metabolic process	GO:1900542	115	0.012
catabolic process	GO:0009056	351	0.012
cartilage development	GO:0051216	22	0.012
positive regulation of protein metabolic process	GO:0051247	178	0.012
response to radiation	GO:0009314	137	0.012
vesicle mediated transport	GO:0016192	181	0.012
calcium ion transmembrane transport	GO:0070588	70	0.012
embryonic limb morphogenesis	GO:0030326	4	0.012
regulation of protein metabolic process	GO:0051246	289	0.012
regulation of molecular function	GO:0065009	398	0.012	Rat
cellular carbohydrate metabolic process	GO:0044262	72	0.012
nucleoside monophosphate metabolic process	GO:0009123	93	0.012
negative regulation of cell communication	GO:0010648	158	0.012
peristalsis	GO:0030432	2	0.012
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.012
purine containing compound catabolic process	GO:0072523	138	0.012
cerebral cortex cell migration	GO:0021795	4	0.012
nucleotide biosynthetic process	GO:0009165	98	0.011
regulation of cellular amine metabolic process	GO:0033238	8	0.011
regulation of cell growth	GO:0001558	85	0.011
endocytosis	GO:0006897	84	0.011
spinal cord development	GO:0021510	27	0.011
synapse assembly	GO:0007416	29	0.011
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.011
sensory perception of bitter taste	GO:0050913	4	0.011
cell cell signaling	GO:0007267	335	0.011	Rat
response to nutrient levels	GO:0031667	370	0.011
regulation of muscle contraction	GO:0006937	53	0.011
regulation of actin filament based process	GO:0032970	42	0.011
inner ear receptor cell differentiation	GO:0060113	2	0.011
ribonucleoside catabolic process	GO:0042454	126	0.011
positive regulation of neuron differentiation	GO:0045666	126	0.011
regulation of cellular localization	GO:0060341	263	0.011
regulation of homotypic cell cell adhesion	GO:0034110	4	0.011
response to wounding	GO:0009611	254	0.011	Rat
positive regulation of growth	GO:0045927	55	0.011	Rat
cellular response to extracellular stimulus	GO:0031668	73	0.011
cognition	GO:0050890	92	0.011
regulation of activation of janus kinase activity	GO:0010533	1	0.011
embryonic pattern specification	GO:0009880	1	0.011
muscle structure development	GO:0061061	87	0.011	Rat
cellular nitrogen compound catabolic process	GO:0044270	163	0.011
response to cold	GO:0009409	29	0.011
regulation of cellular component movement	GO:0051270	150	0.011
glomerular mesangium development	GO:0072109	4	0.011
glial cell differentiation	GO:0010001	65	0.010
sex differentiation	GO:0007548	113	0.010	Rat
amine metabolic process	GO:0009308	38	0.010	Rat
positive regulation of the force of heart contraction by chemical signal	GO:0003099	2	0.010
response to acid chemical	GO:0001101	222	0.010
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.010
cellular macromolecule localization	GO:0070727	122	0.010
regulation of transferase activity	GO:0051338	123	0.010
embryonic axis specification	GO:0000578	1	0.010
learning or memory	GO:0007611	90	0.010
positive regulation of cell proliferation	GO:0008284	249	0.010	Rat
regulation of blood pressure	GO:0008217	83	0.010
involuntary skeletal muscle contraction	GO:0003011	2	0.010
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.010
hormone secretion	GO:0046879	115	0.010
reproductive system development	GO:0061458	128	0.010	Rat
purine containing compound metabolic process	GO:0072521	253	0.010
hematopoietic progenitor cell differentiation	GO:0002244	2	0.010
hair cell differentiation	GO:0035315	2	0.010
cation homeostasis	GO:0055080	195	0.010
response to biotic stimulus	GO:0009607	226	0.010	Rat
locomotion	GO:0040011	237	0.010
positive regulation of nucleotide metabolic process	GO:0045981	91	0.010
appendage morphogenesis	GO:0035107	4	0.010

Fgf22 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	urinary system disease	DOID:18	0	0.028
	disease of anatomical entity	DOID:7	0	0.028

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