IMP: Integrative Multi-species Prediction

Rattus norvegicus

42 known processes

Pgrmc1

progesterone receptor membrane component 1

(Aliases: 25Dx,MPR,25-Dx,VEMA)

Entrez: 291948
Ensembl: ENSRNOG00000012786
RGD: 70890
UniProtKB: P70580

Process Predictions
Disease Predictions

Pgrmc1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
organonitrogen compound biosynthetic process	GO:1901566	167	0.401
neuron development	GO:0048666	286	0.222
single organism biosynthetic process	GO:0044711	342	0.186
response to interleukin 15	GO:0070672	4	0.149
oxoacid metabolic process	GO:0043436	290	0.133
organic acid metabolic process	GO:0006082	292	0.132
organophosphate biosynthetic process	GO:0090407	143	0.112
carbohydrate derivative metabolic process	GO:1901135	346	0.105
cellular component assembly	GO:0022607	360	0.105
nucleoside phosphate biosynthetic process	GO:1901293	102	0.100
brain development	GO:0007420	247	0.099
nucleotide biosynthetic process	GO:0009165	98	0.096
small molecule biosynthetic process	GO:0044283	124	0.096
ribose phosphate biosynthetic process	GO:0046390	87	0.087
cellular catabolic process	GO:0044248	295	0.084
carbohydrate derivative biosynthetic process	GO:1901137	124	0.084
neuron differentiation	GO:0030182	368	0.081
organophosphate metabolic process	GO:0019637	370	0.080
nonribosomal peptide biosynthetic process	GO:0019184	3	0.079
central nervous system development	GO:0007417	311	0.078
regulation of cell maturation	GO:1903429	3	0.077
response to vitamin	GO:0033273	131	0.077
organic acid biosynthetic process	GO:0016053	83	0.077
response to extracellular stimulus	GO:0009991	380	0.076
carboxylic acid biosynthetic process	GO:0046394	83	0.075
organelle organization	GO:0006996	266	0.070
cellular amino acid metabolic process	GO:0006520	107	0.069
response to nutrient levels	GO:0031667	370	0.069
aging	GO:0007568	241	0.065
response to glucocorticoid	GO:0051384	223	0.065
response to metal ion	GO:0010038	253	0.064
head development	GO:0060322	247	0.064
response to toxic substance	GO:0009636	133	0.063
cellular response to stress	GO:0033554	269	0.062
response to nutrient	GO:0007584	248	0.062
endocytosis	GO:0006897	84	0.060
cellular amino acid biosynthetic process	GO:0008652	32	0.058
cellular response to peptide hormone stimulus	GO:0071375	120	0.057
regulation of hormone levels	GO:0010817	187	0.055
nucleobase biosynthetic process	GO:0046112	2	0.053
single organism reproductive process	GO:0044702	297	0.053
response to hypoxia	GO:0001666	231	0.052
axon cargo transport	GO:0008088	1	0.052
cellular lipid metabolic process	GO:0044255	208	0.050
cation transport	GO:0006812	382	0.050
macroautophagy	GO:0016236	4	0.050
nucleotide metabolic process	GO:0009117	279	0.050
cellular response to organic cyclic compound	GO:0071407	202	0.049
secretion	GO:0046903	307	0.049
response to carbohydrate	GO:0009743	183	0.048
nucleobase containing small molecule metabolic process	GO:0055086	316	0.046
response to oxygen levels	GO:0070482	265	0.045
cellular amine metabolic process	GO:0044106	38	0.045
phosphatidylcholine biosynthetic process	GO:0006656	5	0.045
entrainment of circadian clock	GO:0009649	3	0.044
response to other organism	GO:0051707	220	0.044
response to ethanol	GO:0045471	162	0.043
ribonucleotide biosynthetic process	GO:0009260	85	0.042
nucleoside triphosphate metabolic process	GO:0009141	144	0.042
multicellular organismal reproductive process	GO:0048609	233	0.042
multi organism reproductive process	GO:0044703	262	0.042
cellular homeostasis	GO:0019725	252	0.041
lipid metabolic process	GO:0006629	283	0.041
establishment of protein localization	GO:0045184	141	0.041
amine metabolic process	GO:0009308	38	0.040
protein complex subunit organization	GO:0071822	302	0.040
neuron projection development	GO:0031175	273	0.038
glycerolipid metabolic process	GO:0046486	67	0.037
developmental process involved in reproduction	GO:0003006	159	0.036
ribonucleotide metabolic process	GO:0009259	231	0.036
carboxylic acid metabolic process	GO:0019752	289	0.036
glutathione metabolic process	GO:0006749	15	0.036
nucleoside metabolic process	GO:0009116	179	0.036
metal ion transport	GO:0030001	289	0.035
purine nucleotide metabolic process	GO:0006163	229	0.035
homeostatic process	GO:0042592	331	0.034
response to alkaloid	GO:0043279	132	0.034
cellular amide metabolic process	GO:0043603	44	0.033
cellular component biogenesis	GO:0044085	368	0.033
glycerophospholipid metabolic process	GO:0006650	47	0.033
cell projection organization	GO:0030030	302	0.033
positive regulation of transport	GO:0051050	245	0.033
response to wounding	GO:0009611	254	0.033
response to monosaccharide	GO:0034284	159	0.032
nucleoside phosphate metabolic process	GO:0006753	283	0.032
metal ion homeostasis	GO:0055065	186	0.032
programmed cell death	GO:0012501	392	0.032
regulation of glycoprotein metabolic process	GO:1903018	6	0.032
g protein coupled receptor signaling pathway	GO:0007186	242	0.031
purine nucleotide biosynthetic process	GO:0006164	83	0.031
response to vitamin e	GO:0033197	24	0.031
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.030
macromolecular complex assembly	GO:0065003	273	0.030
purine ribonucleotide metabolic process	GO:0009150	227	0.029
apoptotic process	GO:0006915	381	0.029
positive regulation of secretion	GO:0051047	140	0.029
regeneration	GO:0031099	163	0.029
organic acid transport	GO:0015849	116	0.028
glycosyl compound metabolic process	GO:1901657	182	0.028
regulation of apoptotic process	GO:0042981	335	0.028
regulation of programmed cell death	GO:0043067	341	0.028
chemical homeostasis	GO:0048878	292	0.028
regulation of secretion	GO:0051046	224	0.028
regulation of protein metabolic process	GO:0051246	289	0.028
reproductive process	GO:0022414	372	0.028
response to peptide	GO:1901652	292	0.027
catabolic process	GO:0009056	351	0.027
organic anion transport	GO:0015711	132	0.027
anion transport	GO:0006820	178	0.027
deoxyribose phosphate metabolic process	GO:0019692	9	0.026
neuron apoptotic process	GO:0051402	88	0.026
response to insulin	GO:0032868	133	0.026
endomembrane system organization	GO:0010256	48	0.026
cellular modified amino acid metabolic process	GO:0006575	61	0.026
response to radiation	GO:0009314	137	0.025
response to amino acid	GO:0043200	75	0.025
response to inorganic substance	GO:0010035	377	0.025
multicellular organism reproduction	GO:0032504	233	0.025
response to cytokine	GO:0034097	215	0.025
response to peptide hormone	GO:0043434	278	0.025
regulation of molecular function	GO:0065009	398	0.025
cellular cation homeostasis	GO:0030003	180	0.024
cellular modified amino acid biosynthetic process	GO:0042398	18	0.024
single organism carbohydrate metabolic process	GO:0044723	118	0.024
ribose phosphate metabolic process	GO:0019693	235	0.024
l serine transport	GO:0015825	3	0.024
regulation of cell development	GO:0060284	263	0.024
lipid biosynthetic process	GO:0008610	128	0.024
sex differentiation	GO:0007548	113	0.024
regulation of cellular localization	GO:0060341	263	0.024
response to corticosteroid	GO:0031960	235	0.024
positive regulation of cell communication	GO:0010647	271	0.023
regulation of transporter activity	GO:0032409	50	0.023
melanosome localization	GO:0032400	1	0.023
negative regulation of cell death	GO:0060548	229	0.023
synaptic growth at neuromuscular junction	GO:0051124	1	0.023
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.023
cellular metal ion homeostasis	GO:0006875	172	0.022
response to oxidative stress	GO:0006979	186	0.022
regulation of protein transport	GO:0051223	68	0.022
reproductive structure development	GO:0048608	128	0.022
cellular chemical homeostasis	GO:0055082	247	0.022
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.021
response to bacterium	GO:0009617	200	0.021
purine containing compound metabolic process	GO:0072521	253	0.021
regulation of peptide transport	GO:0090087	87	0.021
negative regulation of neuron apoptotic process	GO:0043524	45	0.021
intracellular signal transduction	GO:0035556	314	0.021
locomotion	GO:0040011	237	0.021
organic substance catabolic process	GO:1901575	316	0.020
cellular response to external stimulus	GO:0071496	118	0.020
regulation of transferase activity	GO:0051338	123	0.020
gamete generation	GO:0007276	124	0.020
gonad development	GO:0008406	104	0.020
cell growth	GO:0016049	104	0.020
regulation of cellular amine metabolic process	GO:0033238	8	0.019
hormone secretion	GO:0046879	115	0.019
regulation of anatomical structure size	GO:0090066	135	0.019
golgi organization	GO:0007030	17	0.019
cellular response to extracellular stimulus	GO:0031668	73	0.019
reproductive system development	GO:0061458	128	0.019
regulation of ion transport	GO:0043269	245	0.019
single organism catabolic process	GO:0044712	283	0.019
dendrite development	GO:0016358	72	0.019
cellular calcium ion homeostasis	GO:0006874	160	0.019
protein complex assembly	GO:0006461	263	0.019
p38mapk cascade	GO:0038066	1	0.019
cell adhesion	GO:0007155	110	0.018
cell cell signaling	GO:0007267	335	0.018
neuron projection morphogenesis	GO:0048812	122	0.018
calcium ion homeostasis	GO:0055074	162	0.018
macromolecule localization	GO:0033036	252	0.018
protein complex biogenesis	GO:0070271	263	0.018
positive regulation of hormone secretion	GO:0046887	65	0.018
peptide biosynthetic process	GO:0043043	3	0.018
cytosolic calcium ion homeostasis	GO:0051480	140	0.018
purine nucleoside metabolic process	GO:0042278	169	0.018
peptide metabolic process	GO:0006518	32	0.018
positive regulation of cellular amine metabolic process	GO:0033240	3	0.018
regulation of neuron death	GO:1901214	115	0.018
positive regulation of signaling	GO:0023056	270	0.017
response to nitrosative stress	GO:0051409	2	0.017
carbohydrate metabolic process	GO:0005975	130	0.017
response to molecule of bacterial origin	GO:0002237	194	0.017
defense response	GO:0006952	194	0.017
purine containing compound biosynthetic process	GO:0072522	85	0.017
regulation of establishment of protein localization	GO:0070201	69	0.017
response to reactive oxygen species	GO:0000302	120	0.017
response to decreased oxygen levels	GO:0036293	237	0.017
reproduction	GO:0000003	245	0.017
response to hydrogen peroxide	GO:0042542	89	0.017
cytokinetic process	GO:0032506	1	0.017
rhythmic process	GO:0048511	156	0.017
regulation of proteasomal protein catabolic process	GO:0061136	4	0.017
regulation of cell growth	GO:0001558	85	0.017
response to estrogen	GO:0043627	232	0.017
positive regulation of protein metabolic process	GO:0051247	178	0.017
monocarboxylic acid biosynthetic process	GO:0072330	48	0.017
secretion by cell	GO:0032940	248	0.017
dendrite morphogenesis	GO:0048813	43	0.016
organic hydroxy compound metabolic process	GO:1901615	115	0.016
nucleic acid templated transcription	GO:0097659	379	0.016
2 deoxyribonucleotide metabolic process	GO:0009394	9	0.016
single organism organelle organization	GO:1902589	180	0.016
nucleoside phosphate catabolic process	GO:1901292	140	0.016
nucleobase containing compound catabolic process	GO:0034655	152	0.016
chemosensory behavior	GO:0007635	2	0.016
neuron death	GO:0070997	127	0.016
cation homeostasis	GO:0055080	195	0.016
negative regulation of metabolic process	GO:0009892	331	0.016
nucleoside monophosphate catabolic process	GO:0009125	56	0.016
protein modification by small protein conjugation or removal	GO:0070647	35	0.016
response to activity	GO:0014823	73	0.015
regulation of protein localization	GO:0032880	81	0.015
development of primary sexual characteristics	GO:0045137	107	0.015
regulation of neuron differentiation	GO:0045664	208	0.015
organonitrogen compound catabolic process	GO:1901565	179	0.015
response to herbicide	GO:0009635	16	0.015
response to starvation	GO:0042594	59	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.015
regulation of catalytic activity	GO:0050790	304	0.015
phthalate metabolic process	GO:0018963	8	0.015
protein transport	GO:0015031	132	0.015
regulation of protein modification process	GO:0031399	194	0.015
ureteric bud development	GO:0001657	14	0.015
ribonucleoside biosynthetic process	GO:0042455	25	0.015
organic cyclic compound catabolic process	GO:1901361	175	0.015
cellular response to fluid shear stress	GO:0071498	4	0.014
response to external biotic stimulus	GO:0043207	221	0.014
neuronal action potential	GO:0019228	35	0.014
benzene containing compound metabolic process	GO:0042537	22	0.014
divalent inorganic cation homeostasis	GO:0072507	165	0.014
negative regulation of programmed cell death	GO:0043069	183	0.014
phosphatidylethanolamine metabolic process	GO:0046337	1	0.014
regulation of cell projection organization	GO:0031344	175	0.014
regulation of protein phosphorylation	GO:0001932	183	0.014
regulation of phosphorus metabolic process	GO:0051174	349	0.014
biological adhesion	GO:0022610	110	0.014
vesicle mediated transport	GO:0016192	181	0.014
response to biotic stimulus	GO:0009607	226	0.014
cellular response to reactive oxygen species	GO:0034614	55	0.014
positive regulation of response to stimulus	GO:0048584	285	0.014
macromolecular complex subunit organization	GO:0043933	339	0.014
positive regulation of peptide hormone secretion	GO:0090277	50	0.014
positive regulation of multicellular organismal process	GO:0051240	387	0.014
monocarboxylic acid transport	GO:0015718	52	0.014
reactive oxygen species metabolic process	GO:0072593	37	0.014
response to light stimulus	GO:0009416	52	0.013
regulation of phosphorylation	GO:0042325	248	0.013
mapk cascade	GO:0000165	140	0.013
phosphatidylinositol dephosphorylation	GO:0046856	4	0.013
organelle localization	GO:0051640	55	0.013
acid secretion	GO:0046717	48	0.013
lipid transport	GO:0006869	61	0.013
circulatory system process	GO:0003013	183	0.013
negative regulation of macromolecule metabolic process	GO:0010605	260	0.013
regulation of intracellular signal transduction	GO:1902531	218	0.013
coenzyme metabolic process	GO:0006732	86	0.013
regulation of response to stress	GO:0080134	126	0.013
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.013
oxidation reduction process	GO:0055114	304	0.013
purine ribonucleoside catabolic process	GO:0046130	124	0.013
regulation of cellular component size	GO:0032535	51	0.013
positive regulation of nervous system development	GO:0051962	178	0.013
negative regulation of gene expression	GO:0010629	199	0.013
purine containing compound catabolic process	GO:0072523	138	0.013
regulation of cellular protein metabolic process	GO:0032268	267	0.013
regulation of cellular amino acid metabolic process	GO:0006521	2	0.013
multicellular organismal signaling	GO:0035637	44	0.013
proteolysis	GO:0006508	175	0.013
cell type specific apoptotic process	GO:0097285	134	0.013
regulation of neuron apoptotic process	GO:0043523	83	0.013
phospholipid biosynthetic process	GO:0008654	29	0.013
muscle structure development	GO:0061061	87	0.013
wound healing	GO:0042060	122	0.013
positive regulation of molecular function	GO:0044093	230	0.013
ribonucleoside metabolic process	GO:0009119	174	0.013
neurological system process	GO:0050877	219	0.013
olfactory learning	GO:0008355	1	0.012
regulation of blood pressure	GO:0008217	83	0.012
negative regulation of apoptotic process	GO:0043066	181	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.012
cellular ion homeostasis	GO:0006873	184	0.012
sexual reproduction	GO:0019953	148	0.012
response to fatty acid	GO:0070542	65	0.012
regulation of cell differentiation	GO:0045595	320	0.012
regulation of dendrite development	GO:0050773	59	0.012
female pregnancy	GO:0007565	122	0.012
positive regulation of secretion by cell	GO:1903532	128	0.012
negative regulation of molecular function	GO:0044092	133	0.012
regulation of neurogenesis	GO:0050767	247	0.012
anterior posterior pattern specification	GO:0009952	1	0.012
cell part morphogenesis	GO:0032990	123	0.012
developmental growth	GO:0048589	100	0.012
developmental growth involved in morphogenesis	GO:0060560	33	0.012
regulation of phosphate metabolic process	GO:0019220	349	0.012
positive regulation of intracellular signal transduction	GO:1902533	138	0.012
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.012
regulation of hormone secretion	GO:0046883	106	0.011
positive regulation of catalytic activity	GO:0043085	184	0.011
divalent inorganic cation transport	GO:0072511	134	0.011
peptide transport	GO:0015833	97	0.011
pyrimidine nucleotide metabolic process	GO:0006220	9	0.011
multi multicellular organism process	GO:0044706	138	0.011
cellular component movement	GO:0006928	248	0.011
regulation of secretion by cell	GO:1903530	208	0.011
response to corticosterone	GO:0051412	40	0.011
receptor mediated endocytosis	GO:0006898	42	0.011
regulation of system process	GO:0044057	208	0.011
response to acid chemical	GO:0001101	222	0.011
hormone transport	GO:0009914	121	0.011
regulation of growth	GO:0040008	105	0.011
single organism cellular localization	GO:1902580	102	0.011
protein localization	GO:0008104	191	0.011
purine nucleoside catabolic process	GO:0006152	124	0.011
phospholipid metabolic process	GO:0006644	61	0.011
purine ribonucleotide biosynthetic process	GO:0009152	81	0.011
monocarboxylic acid metabolic process	GO:0032787	152	0.011
ovulation cycle process	GO:0022602	50	0.011
peptide secretion	GO:0002790	86	0.011
fatty acid transport	GO:0015908	25	0.011
ion homeostasis	GO:0050801	212	0.011
regulation of cellular component organization	GO:0051128	368	0.011
regulation of multicellular organismal development	GO:2000026	376	0.011
regulation of transcription dna templated	GO:0006355	374	0.011
tissue development	GO:0009888	252	0.011
sulfur compound metabolic process	GO:0006790	70	0.011
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	41	0.011
regulation of peptide hormone secretion	GO:0090276	80	0.010
cell morphogenesis involved in differentiation	GO:0000904	119	0.010
cellular macromolecule catabolic process	GO:0044265	29	0.010
response to glucose	GO:0009749	136	0.010
cellular response to growth factor stimulus	GO:0071363	162	0.010
immune response	GO:0006955	104	0.010
lipid localization	GO:0010876	62	0.010
amide transport	GO:0042886	105	0.010
protein localization to chromosome centromeric region	GO:0071459	1	0.010
cytoplasmic transport	GO:0016482	115	0.010
nitrogen compound transport	GO:0071705	229	0.010
hormone metabolic process	GO:0042445	69	0.010
actin filament depolymerization	GO:0030042	3	0.010
response to vitamin a	GO:0033189	36	0.010
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.010
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.010
regulation of peptide secretion	GO:0002791	82	0.010
positive regulation of transferase activity	GO:0051347	81	0.010
transcription from rna polymerase ii promoter	GO:0006366	252	0.010
regulation of signal transduction	GO:0009966	318	0.010
negative regulation of stress activated protein kinase signaling cascade	GO:0070303	4	0.010
carboxylic acid transport	GO:0046942	115	0.010
response to estradiol	GO:0032355	164	0.010
regulation of insulin secretion	GO:0050796	65	0.010

Pgrmc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of metabolism	DOID:0014667	0	0.015
	inherited metabolic disorder	DOID:655	0	0.010

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