Rattus norvegicus

190 known processes

Shh

sonic hedgehog

Shh biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of transcription dna templatedGO:00458931970.369
Human Rat
cellular amide metabolic processGO:0043603440.350
negative regulation of nitrogen compound metabolic processGO:00511721610.348
rna metabolic processGO:00160704060.248
Human Rat
regulation of rna metabolic processGO:00512523910.231
Human Rat
negative regulation of metabolic processGO:00098923310.226
negative regulation of nucleic acid templated transcriptionGO:19035071170.222
negative regulation of cellular metabolic processGO:00313242810.207
cell part morphogenesisGO:00329901230.193
cellular component biogenesisGO:00440853680.177
transcription dna templatedGO:00063513770.173
Human Rat
regulation of transcription from rna polymerase ii promoterGO:00063572340.167
Rat
response to metal ionGO:00100382530.167
regulation of nucleic acid templated transcriptionGO:19035063800.165
Human Rat
response to corticosteroidGO:00319602350.153
regulation of programmed cell deathGO:00430673410.146
head developmentGO:00603222470.142
cellular component morphogenesisGO:00329891550.141
negative regulation of macromolecule metabolic processGO:00106052600.134
response to nutrient levelsGO:00316673700.128
cation transportGO:00068123820.127
positive regulation of nucleic acid templated transcriptionGO:19035081970.126
Human Rat
negative regulation of gene expressionGO:00106291990.118
negative regulation of rna biosynthetic processGO:19026791180.116
anatomical structure morphogenesisGO:00096532980.112
protein complex assemblyGO:00064612630.110
transmembrane transportGO:00550854120.100
cell morphogenesis involved in differentiationGO:00009041190.097
monovalent inorganic cation transportGO:00156721720.096
response to purine containing compoundGO:00140741260.093
neuron differentiationGO:00301823680.093
rna biosynthetic processGO:00327743800.092
Human Rat
agingGO:00075682410.092
apoptotic processGO:00069153810.089
cell projection organizationGO:00300303020.088
macromolecular complex subunit organizationGO:00439333390.087
divalent metal ion transportGO:00708381320.085
positive regulation of programmed cell deathGO:00430681570.085
positive regulation of macromolecule biosynthetic processGO:00105572470.083
Human Rat
negative regulation of rna metabolic processGO:00512531230.083
programmed cell deathGO:00125013920.082
positive regulation of rna metabolic processGO:00512542030.081
Human Rat
negative regulation of cellular biosynthetic processGO:00313271610.078
cellular component assemblyGO:00226073600.075
positive regulation of biosynthetic processGO:00098913190.075
Human Rat
response to organophosphorusGO:00466831020.074
brain developmentGO:00074202470.074
nucleic acid templated transcriptionGO:00976593790.073
Human Rat
central nervous system developmentGO:00074173110.073
negative regulation of transcription dna templatedGO:00458921160.071
positive regulation of gene expressionGO:00106282440.070
Human Rat
response to inorganic substanceGO:00100353770.070
response to peptide hormoneGO:00434342780.069
positive regulation of rna biosynthetic processGO:19026801970.068
Human Rat
macromolecular complex assemblyGO:00650032730.063
positive regulation of nucleobase containing compound metabolic processGO:00459353190.063
Human Rat
transcription from rna polymerase ii promoterGO:00063662520.062
Rat
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.061
neuron projection morphogenesisGO:00488121220.059
protein phosphorylationGO:00064683450.059
cell projection morphogenesisGO:00488581230.059
peptide metabolic processGO:0006518320.059
neuron projection developmentGO:00311752730.058
calcium ion transportGO:00068161310.057
regulation of cellular component organizationGO:00511283680.056
regulation of rna biosynthetic processGO:20011413810.055
Human Rat
protein homooligomerizationGO:0051260910.054
oxoacid metabolic processGO:00434362900.053
cell morphogenesisGO:00009021420.053
single organism reproductive processGO:00447022970.052
intestinal absorptionGO:005089230.052
negative regulation of response to stimulusGO:00485851550.052
Rat
cellular response to nitrogen compoundGO:19016992100.052
negative regulation of programmed cell deathGO:00430691830.049
negative regulation of macromolecule biosynthetic processGO:00105581480.048
cellular homeostasisGO:00197252520.047
response to glucocorticoidGO:00513842230.047
positive regulation of nitrogen compound metabolic processGO:00511733340.046
Human Rat
positive regulation of cellular component organizationGO:00511302000.046
cellular metal ion homeostasisGO:00068751720.044
negative regulation of cell deathGO:00605482290.044
protein oligomerizationGO:00512591910.043
response to peptideGO:19016522920.043
sex differentiationGO:00075481130.042
positive regulation of multicellular organismal processGO:00512403870.042
organelle organizationGO:00069962660.042
response to hexoseGO:00097461440.042
response to glucoseGO:00097491360.042
cellular response to steroid hormone stimulusGO:0071383930.041
chemical homeostasisGO:00488782920.041
protein complex biogenesisGO:00702712630.041
carboxylic acid metabolic processGO:00197522890.040
regulation of multicellular organismal developmentGO:20000263760.039
metal ion transportGO:00300012890.039
divalent inorganic cation transportGO:00725111340.037
regulation of cell proliferationGO:00421273590.037
response to extracellular stimulusGO:00099913800.037
negative regulation of apoptotic processGO:00430661810.036
regulation of transcription dna templatedGO:00063553740.036
Human Rat
negative regulation of developmental processGO:00510931250.036
ion transmembrane transportGO:00342203650.036
ribonucleotide metabolic processGO:00092592310.036
regulation of protein metabolic processGO:00512462890.035
negative regulation of nucleobase containing compound metabolic processGO:00459341530.035
neuron developmentGO:00486662860.035
cellular chemical homeostasisGO:00550822470.034
positive regulation of cell deathGO:00109421840.034
cellular amino acid metabolic processGO:00065201070.034
peptide secretionGO:0002790860.033
response to other organismGO:00517072200.033
response to oxidative stressGO:00069791860.033
regulation of synaptic transmissionGO:00508041410.033
negative regulation of luteinizing hormone secretionGO:003368540.033
homeostatic processGO:00425923310.033
response to hypoxiaGO:00016662310.032
regulation of system processGO:00440572080.032
g protein coupled receptor signaling pathwayGO:00071862420.032
cell morphogenesis involved in neuron differentiationGO:00486671060.031
response to woundingGO:00096112540.031
regulation of molecular functionGO:00650093980.031
regulation of calcium ion transportGO:0051924770.031
organophosphate metabolic processGO:00196373700.031
inorganic ion transmembrane transportGO:00986602290.030
response to calcium ionGO:0051592590.030
organ regenerationGO:00311001010.030
negative regulation of multicellular organismal processGO:00512412030.029
cellular response to organic cyclic compoundGO:00714072020.029
positive regulation of cellular biosynthetic processGO:00313282950.029
Human Rat
protein maturationGO:0051604680.029
response to oxygen levelsGO:00704822650.029
dendrite developmentGO:0016358720.028
reproductive processGO:00224143720.028
cellular response to external stimulusGO:00714961180.028
regulation of apoptotic processGO:00429813350.028
cellular response to interleukin 6GO:007135490.027
cellular response to organonitrogen compoundGO:00714171970.027
regulation of cellular amino acid metabolic processGO:000652120.027
cell type specific apoptotic processGO:00972851340.027
protein heterooligomerizationGO:0051291890.027
negative regulation of neuron differentiationGO:0045665620.027
metal ion homeostasisGO:00550651860.027
cellular response to hormone stimulusGO:00328702470.026
hormone transportGO:00099141210.026
axonogenesisGO:0007409710.026
positive regulation of cell proliferationGO:00082842490.025
motor neuron axon guidanceGO:000804510.025
regulation of catalytic activityGO:00507903040.025
response to bacteriumGO:00096172000.025
positive regulation of phosphorylationGO:00423271770.025
multicellular organismal reproductive processGO:00486092330.025
regulation of metal ion transportGO:00109591180.024
regulation of phosphorylationGO:00423252480.024
reproductive system developmentGO:00614581280.024
cellular response to oxygen containing compoundGO:19017013860.024
regulation of neuron differentiationGO:00456642080.024
reproductionGO:00000032450.024
synaptic transmissionGO:00072682350.024
positive regulation of protein metabolic processGO:00512471780.024
locomotionGO:00400112370.024
proteolysisGO:00065081750.024
regulation of cellular ketone metabolic processGO:0010565270.024
pancreatic stellate cell proliferationGO:007234320.023
regulation of phosphate metabolic processGO:00192203490.023
regenerationGO:00310991630.023
organic acid metabolic processGO:00060822920.023
regulation of phosphorus metabolic processGO:00511743490.023
cellular component movementGO:00069282480.023
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.023
positive regulation of developmental processGO:00510942830.023
regulation of cell projection organizationGO:00313441750.023
neurotransmitter transportGO:0006836420.023
regulation of nervous system developmentGO:00519602640.022
developmental growthGO:00485891000.022
response to decreased oxygen levelsGO:00362932370.022
gamete generationGO:00072761240.021
regulation of hormone levelsGO:00108171870.021
regulation of skeletal muscle tissue regenerationGO:004341620.021
regulation of neuron projection developmentGO:00109751610.021
axon developmentGO:0061564960.021
regulation of cellular amine metabolic processGO:003323880.021
axon guidanceGO:0007411240.021
regulation of transmembrane transportGO:00347621220.020
response to mineralocorticoidGO:0051385490.020
response to monosaccharideGO:00342841590.020
defense responseGO:00069521940.020
gland developmentGO:00487321550.020
response to cytokineGO:00340972150.020
purine ribonucleotide metabolic processGO:00091502270.020
cation homeostasisGO:00550801950.020
positive regulation of apoptotic processGO:00430651540.020
response to increased oxygen levelsGO:0036296450.020
intracellular signal transductionGO:00355563140.019
response to mechanical stimulusGO:00096121340.019
erythrocyte aggregationGO:003411710.019
chromosome segregationGO:000705920.019
response to toxic substanceGO:00096361330.019
single organism organelle organizationGO:19025891800.019
cellular ion homeostasisGO:00068731840.019
calcium ion homeostasisGO:00550741620.018
negative regulation of biosynthetic processGO:00098901680.018
multicellular organism reproductionGO:00325042330.018
protein complex subunit organizationGO:00718223020.018
insulin secretionGO:0030073690.018
cellular divalent inorganic cation homeostasisGO:00725031620.018
cellular response to stressGO:00335542690.018
response to estrogenGO:00436272320.018
negative regulation of neurogenesisGO:0050768780.018
peptide transportGO:0015833970.018
response to transition metal nanoparticleGO:19902671220.018
cellular ketone metabolic processGO:0042180510.018
anion transportGO:00068201780.018
gonad developmentGO:00084061040.018
ribose phosphate metabolic processGO:00196932350.017
positive regulation of cellular amino acid metabolic processGO:004576410.017
regulation of cellular protein metabolic processGO:00322682670.017
regulation of neurotransmitter uptakeGO:005158010.017
regulation of neurotransmitter levelsGO:0001505420.017
dorsal ventral axon guidanceGO:003356310.017
response to nutrientGO:00075842480.017
regulation of ion transmembrane transportGO:00347651210.016
cellular response to acid chemicalGO:0071229750.016
response to campGO:0051591910.016
protein processingGO:0016485680.016
lateral ventricle developmentGO:002167010.016
regulation of cell differentiationGO:00455953200.016
hematopoietic progenitor cell differentiationGO:000224420.016
Human
salivary gland developmentGO:000743130.016
urogenital system developmentGO:0001655780.016
positive regulation of protein phosphorylationGO:00019341350.016
regulation of pancreatic stellate cell proliferationGO:200022920.016
regulation of growthGO:00400081050.016
localization of cellGO:00516742020.015
interleukin 1 secretionGO:005070130.015
purine ribonucleoside catabolic processGO:00461301240.015
divalent inorganic cation homeostasisGO:00725071650.015
multicellular organismal homeostasisGO:0048871490.015
inorganic cation transmembrane transportGO:00986622020.015
response to acid chemicalGO:00011012220.015
membrane organizationGO:0061024940.015
cellular cation homeostasisGO:00300031800.015
growthGO:00400071650.015
potassium ion transportGO:0006813970.015
regulation of cell morphogenesis involved in differentiationGO:0010769720.015
regulation of organelle organizationGO:0033043800.015
gliogenesisGO:0042063930.014
negative regulation of cell differentiationGO:0045596990.014
regulation of dendrite developmentGO:0050773590.014
regulation of neurogenesisGO:00507672470.014
muscle system processGO:00030121150.014
canalicular bile acid transportGO:001572250.014
tissue developmentGO:00098882520.014
thyroid gland developmentGO:003087810.014
cellular response to lipidGO:00713962010.014
response to reactive oxygen speciesGO:00003021200.014
regulation of synaptic plasticityGO:0048167700.014
complement receptor mediated signaling pathwayGO:000243020.014
negative regulation of molecular functionGO:00440921330.014
cell migrationGO:00164771970.014
epithelial cell differentiationGO:0030855710.014
regulation of cell growthGO:0001558850.014
hepaticobiliary system developmentGO:0061008900.014
cellular response to fluid shear stressGO:007149840.014
sexual reproductionGO:00199531480.013
regulation of protein modification processGO:00313991940.013
regulation of protein phosphorylationGO:00019321830.013
antigen processing and presentationGO:001988220.013
glucose homeostasisGO:0042593750.013
regulation of response to woundingGO:1903034690.013
ion homeostasisGO:00508012120.013
regulation of response to stressGO:00801341260.013
regulation of neuron apoptotic processGO:0043523830.013
response to radiationGO:00093141370.013
cellular response to drugGO:0035690300.013
cell motilityGO:00488702020.013
male mating behaviorGO:006017930.013
cellular response to hexose stimulusGO:0071331650.013
cation transmembrane transportGO:00986552630.013
ribonucleoside catabolic processGO:00424541260.013
multicellular organism growthGO:003526410.013
nitrogen compound transportGO:00717052290.013
carbohydrate derivative metabolic processGO:19011353460.013
response to zinc ionGO:0010043390.013
cellular response to vitamin eGO:007130630.013
regulation of signal transductionGO:00099663180.013
Human Rat
peptide hormone secretionGO:0030072840.013
regulation of locomotionGO:00400121480.013
purine containing compound metabolic processGO:00725212530.012
spermatogenesisGO:0007283990.012
response to ethanolGO:00454711620.012
negative regulation of cell proliferationGO:00082851190.012
actin filament depolymerizationGO:003004230.012
response to carbohydrateGO:00097431830.012
reproductive structure developmentGO:00486081280.012
cellular calcium ion homeostasisGO:00068741600.012
positive regulation of cell projection organizationGO:00313461110.012
regulation of secretion by cellGO:19035302080.012
response to external biotic stimulusGO:00432072210.012
negative regulation of cell developmentGO:0010721820.012
cell fate determinationGO:000170920.012
sodium ion transmembrane transportGO:0035725670.012
negative regulation of calcium ion importGO:009028120.012
amide transportGO:00428861050.012
cardiovascular system developmentGO:00723581340.012
cellular amine metabolic processGO:0044106380.012
cell cell signaling involved in cell fate commitmentGO:004516820.012
parasympathetic nervous system developmentGO:004848610.012
response to estradiolGO:00323551640.012
anatomical structure formation involved in morphogenesisGO:0048646830.011
positive regulation of cellular amine metabolic processGO:003324030.011
regulation of cell morphogenesisGO:0022604770.011
metanephric s shaped body morphogenesisGO:007228420.011
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.011
Rat
blood vessel developmentGO:0001568690.011
odontogenesisGO:0042476320.011
amine metabolic processGO:0009308380.011
response to starvationGO:0042594590.011
regulation of transferase activityGO:00513381230.011
cell cell signalingGO:00072673350.011
Human
negative regulation of response to extracellular stimulusGO:003210570.011
negative regulation of cellular component organizationGO:0051129830.011
regulation of axonogenesisGO:0050770370.011
multicellular organismal water homeostasisGO:005089140.011
negative regulation of nervous system developmentGO:0051961790.011
intracellular receptor signaling pathwayGO:0030522350.011
regulation of hydrolase activityGO:00513361430.011
developmental process involved in reproductionGO:00030061590.010
cellular response to estradiol stimulusGO:0071392160.010
macromolecule localizationGO:00330362520.010
Human
negative regulation of uterine smooth muscle contractionGO:007047320.010
neuron projection guidanceGO:0097485240.010
cellular macromolecule localizationGO:00707271220.010
Human
maintenance of locationGO:0051235170.010
camera type eye developmentGO:0043010480.010
pro t cell differentiationGO:000257210.010
positive regulation of kinase activityGO:0033674770.010
metanephric comma shaped body morphogenesisGO:007227820.010
regulation of response to external stimulusGO:00321011060.010
bone developmentGO:0060348250.010
neuron deathGO:00709971270.010
cellular response to monosaccharide stimulusGO:0071326670.010
response to amineGO:0014075460.010
developmental growth involved in morphogenesisGO:0060560330.010
single organism membrane organizationGO:0044802740.010
negative regulation of immune system processGO:0002683390.010
gastrulationGO:000736920.010
steroid hormone mediated signaling pathwayGO:004340180.010

Shh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
urinary system diseaseDOID:1800.058
disease of anatomical entityDOID:700.058
kidney diseaseDOID:55700.025
nervous system diseaseDOID:86300.023
acquired metabolic diseaseDOID:006015800.018
nutrition diseaseDOID:37400.018
disease of metabolismDOID:001466700.018
obesityDOID:997000.018
overnutritionDOID:65400.018
retinitis pigmentosaDOID:1058400.014
eye diseaseDOID:561400.014
retinal diseaseDOID:567900.014
retinal degenerationDOID:846600.014
sensory system diseaseDOID:005015500.014
eye and adnexa diseaseDOID:149200.014
muscular diseaseDOID:008000000.012
musculoskeletal system diseaseDOID:1700.012
muscle tissue diseaseDOID:6600.012