IMP: Integrative Multi-species Prediction

Rattus norvegicus

17 known processes

Scn4a

sodium channel, voltage-gated, type IV, alpha subunit

(Aliases: microI,NCHVS,Nav1.4)

Ensembl: ENSRNOG00000012134
Entrez: 25722
RGD: 3636
UniProtKB: P15390

Process Predictions
Disease Predictions

Scn4a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
response to corticosteroid	GO:0031960	235	0.758
neurological system process	GO:0050877	219	0.731	Rat
response to estrogen	GO:0043627	232	0.682
regulation of secretion	GO:0051046	224	0.664
regulation of cellular localization	GO:0060341	263	0.654
cellular response to endogenous stimulus	GO:0071495	377	0.613
cation transmembrane transport	GO:0098655	263	0.590	Mouse Rat
cellular response to oxygen containing compound	GO:1901701	386	0.583
cognition	GO:0050890	92	0.581
single organism behavior	GO:0044708	130	0.562
cellular response to organonitrogen compound	GO:0071417	197	0.562
regulation of phosphorus metabolic process	GO:0051174	349	0.537
response to estradiol	GO:0032355	164	0.513
sensory perception	GO:0007600	101	0.461	Rat
nitrogen compound transport	GO:0071705	229	0.441
regulation of transcription dna templated	GO:0006355	374	0.428
neuron neuron synaptic transmission	GO:0007270	60	0.396
secretion by cell	GO:0032940	248	0.386
positive regulation of phosphate metabolic process	GO:0045937	262	0.376
response to wounding	GO:0009611	254	0.371
regulation of cell proliferation	GO:0042127	359	0.356	Rat
synaptic transmission	GO:0007268	235	0.348
carbohydrate derivative biosynthetic process	GO:1901137	124	0.347
rhythmic process	GO:0048511	156	0.345
anion transport	GO:0006820	178	0.344
cellular homeostasis	GO:0019725	252	0.341
regulation of phosphate metabolic process	GO:0019220	349	0.340
regulation of cell development	GO:0060284	263	0.332
circadian rhythm	GO:0007623	88	0.320
positive regulation of cellular biosynthetic process	GO:0031328	295	0.318
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.307
nucleoside phosphate biosynthetic process	GO:1901293	102	0.287
cellular chemical homeostasis	GO:0055082	247	0.280
positive regulation of phosphorylation	GO:0042327	177	0.277
regulation of nucleic acid templated transcription	GO:1903506	380	0.277
response to acid chemical	GO:0001101	222	0.269
response to extracellular stimulus	GO:0009991	380	0.268
positive regulation of biosynthetic process	GO:0009891	319	0.268
protein phosphorylation	GO:0006468	345	0.267
behavior	GO:0007610	205	0.265
cellular response to nitrogen compound	GO:1901699	210	0.264
response to glucocorticoid	GO:0051384	223	0.263
cellular response to hormone stimulus	GO:0032870	247	0.261
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.260
carbohydrate derivative metabolic process	GO:1901135	346	0.257
homeostatic process	GO:0042592	331	0.254
mapk cascade	GO:0000165	140	0.247
transmembrane transport	GO:0055085	412	0.246	Mouse Rat
positive regulation of transcription dna templated	GO:0045893	197	0.246
regulation of rna biosynthetic process	GO:2001141	381	0.239
reproductive process	GO:0022414	372	0.236
regulation of signal transduction	GO:0009966	318	0.233
metal ion transport	GO:0030001	289	0.229
multi organism reproductive process	GO:0044703	262	0.228
multi multicellular organism process	GO:0044706	138	0.225
negative regulation of metabolic process	GO:0009892	331	0.225
regulation of cyclic nucleotide biosynthetic process	GO:0030802	45	0.224
reproduction	GO:0000003	245	0.224
regulation of catecholamine secretion	GO:0050433	32	0.223
positive regulation of cell proliferation	GO:0008284	249	0.222	Rat
negative regulation of multicellular organismal process	GO:0051241	203	0.221
response to alkaloid	GO:0043279	132	0.220
memory	GO:0007613	54	0.219
purine ribonucleotide biosynthetic process	GO:0009152	81	0.217
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.216
rna metabolic process	GO:0016070	406	0.215
potassium ion transport	GO:0006813	97	0.214
protein homooligomerization	GO:0051260	91	0.213
response to nutrient levels	GO:0031667	370	0.212
transcription from rna polymerase ii promoter	GO:0006366	252	0.212
regulation of synaptic transmission	GO:0050804	141	0.208
response to oxygen levels	GO:0070482	265	0.208
multicellular organism reproduction	GO:0032504	233	0.207
organonitrogen compound biosynthetic process	GO:1901566	167	0.202
positive regulation of signal transduction	GO:0009967	175	0.202
chemical homeostasis	GO:0048878	292	0.201
hormone transport	GO:0009914	121	0.200
organophosphate metabolic process	GO:0019637	370	0.199
cardiovascular system development	GO:0072358	134	0.198
positive regulation of cell communication	GO:0010647	271	0.195
camp metabolic process	GO:0046058	63	0.193
regulation of phosphorylation	GO:0042325	248	0.192
positive regulation of rna biosynthetic process	GO:1902680	197	0.187
cellular component assembly	GO:0022607	360	0.187
cellular component biogenesis	GO:0044085	368	0.186
purine containing compound metabolic process	GO:0072521	253	0.182
catecholamine transport	GO:0051937	37	0.182
macromolecular complex subunit organization	GO:0043933	339	0.181
positive regulation of gene expression	GO:0010628	244	0.181
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.180
regulation of system process	GO:0044057	208	0.179	Rat
cellular calcium ion homeostasis	GO:0006874	160	0.178
negative regulation of macromolecule metabolic process	GO:0010605	260	0.178
response to ethanol	GO:0045471	162	0.178
rna biosynthetic process	GO:0032774	380	0.177
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.174
neuron differentiation	GO:0030182	368	0.171
nucleic acid templated transcription	GO:0097659	379	0.169
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.165
cellular response to lipid	GO:0071396	201	0.164
positive regulation of phosphorus metabolic process	GO:0010562	262	0.163
regulation of peptide transport	GO:0090087	87	0.162
response to peptide	GO:1901652	292	0.161
calcium ion homeostasis	GO:0055074	162	0.159
amine transport	GO:0015837	57	0.159
negative regulation of cell proliferation	GO:0008285	119	0.159
ion transmembrane transport	GO:0034220	365	0.159	Mouse Rat
inorganic cation transmembrane transport	GO:0098662	202	0.158	Mouse Rat
cation transport	GO:0006812	382	0.158
inorganic ion transmembrane transport	GO:0098660	229	0.155	Mouse Rat
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.153
regulation of protein modification process	GO:0031399	194	0.151
signal transduction by phosphorylation	GO:0023014	144	0.150
regulation of protein phosphorylation	GO:0001932	183	0.149
cellular metal ion homeostasis	GO:0006875	172	0.148
response to growth factor	GO:0070848	189	0.147
protein oligomerization	GO:0051259	191	0.143
purine nucleotide biosynthetic process	GO:0006164	83	0.142
response to inorganic substance	GO:0010035	377	0.141
brain development	GO:0007420	247	0.139	Rat
inflammatory response	GO:0006954	150	0.138
positive regulation of nervous system development	GO:0051962	178	0.137
regulation of secretion by cell	GO:1903530	208	0.137
intracellular signal transduction	GO:0035556	314	0.135
regulation of intracellular signal transduction	GO:1902531	218	0.134
nucleobase containing small molecule metabolic process	GO:0055086	316	0.134
organic hydroxy compound transport	GO:0015850	77	0.134
positive regulation of developmental process	GO:0051094	283	0.132
cytosolic calcium ion homeostasis	GO:0051480	140	0.132
protein complex subunit organization	GO:0071822	302	0.129
response to carbohydrate	GO:0009743	183	0.129
response to hypoxia	GO:0001666	231	0.129
regulation of cyclase activity	GO:0031279	21	0.129
single organism reproductive process	GO:0044702	297	0.128
secretion	GO:0046903	307	0.127
aging	GO:0007568	241	0.127
positive regulation of protein modification process	GO:0031401	142	0.126
response to ammonium ion	GO:0060359	71	0.125
purine containing compound biosynthetic process	GO:0072522	85	0.124
cyclic nucleotide biosynthetic process	GO:0009190	63	0.124
learning or memory	GO:0007611	90	0.123
regulation of rna metabolic process	GO:0051252	391	0.121
response to radiation	GO:0009314	137	0.121
nucleoside phosphate metabolic process	GO:0006753	283	0.119
cyclic purine nucleotide metabolic process	GO:0052652	62	0.118
cyclic nucleotide metabolic process	GO:0009187	80	0.118
catecholamine secretion	GO:0050432	33	0.118
positive regulation of cyclic nucleotide biosynthetic process	GO:0030804	34	0.117
response to cytokine	GO:0034097	215	0.115
positive regulation of nucleotide metabolic process	GO:0045981	91	0.115
learning	GO:0007612	33	0.115
regulation of cellular protein metabolic process	GO:0032268	267	0.115
regulation of molecular function	GO:0065009	398	0.114
central nervous system development	GO:0007417	311	0.113	Rat
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.113
monoamine transport	GO:0015844	43	0.113
neuron death	GO:0070997	127	0.113
ribonucleotide metabolic process	GO:0009259	231	0.112
response to peptide hormone	GO:0043434	278	0.111
regulation of neurogenesis	GO:0050767	247	0.111
negative regulation of cellular metabolic process	GO:0031324	281	0.111
regulation of dopamine secretion	GO:0014059	15	0.111
positive regulation of mapk cascade	GO:0043410	92	0.111
macromolecule localization	GO:0033036	252	0.110
multicellular organismal reproductive process	GO:0048609	233	0.110
regulation of catalytic activity	GO:0050790	304	0.110
neuron apoptotic process	GO:0051402	88	0.110
negative regulation of programmed cell death	GO:0043069	183	0.108
telencephalon development	GO:0021537	62	0.108	Rat
oxoacid metabolic process	GO:0043436	290	0.106
regulation of programmed cell death	GO:0043067	341	0.106
transcription dna templated	GO:0006351	377	0.106
protein complex biogenesis	GO:0070271	263	0.105
purine ribonucleotide metabolic process	GO:0009150	227	0.104
positive regulation of signaling	GO:0023056	270	0.104
oxidation reduction process	GO:0055114	304	0.103
apoptotic process	GO:0006915	381	0.102
regulation of protein metabolic process	GO:0051246	289	0.102
negative regulation of cell death	GO:0060548	229	0.101
protein complex assembly	GO:0006461	263	0.100
response to decreased oxygen levels	GO:0036293	237	0.100
regulation of nucleotide biosynthetic process	GO:0030808	47	0.100
cell activation	GO:0001775	97	0.098
cellular ion homeostasis	GO:0006873	184	0.097
response to retinoic acid	GO:0032526	63	0.097
ribose phosphate biosynthetic process	GO:0046390	87	0.096
cation homeostasis	GO:0055080	195	0.096
negative regulation of gene expression	GO:0010629	199	0.096
cellular cation homeostasis	GO:0030003	180	0.094
cellular response to stress	GO:0033554	269	0.093
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.093
response to nutrient	GO:0007584	248	0.092
regulation of anatomical structure morphogenesis	GO:0022603	141	0.092
positive regulation of response to stimulus	GO:0048584	285	0.091
negative regulation of phosphorus metabolic process	GO:0010563	80	0.091
regulation of purine nucleotide metabolic process	GO:1900542	115	0.090
synapse organization	GO:0050808	46	0.089
negative regulation of response to stimulus	GO:0048585	155	0.089
neuron development	GO:0048666	286	0.088
regulation of ion transport	GO:0043269	245	0.088	Mouse Rat
nucleotide biosynthetic process	GO:0009165	98	0.088
organelle organization	GO:0006996	266	0.088
negative regulation of signaling	GO:0023057	157	0.088
positive regulation of ion transport	GO:0043270	94	0.087
regulation of cell differentiation	GO:0045595	320	0.087
cellular response to glucocorticoid stimulus	GO:0071385	68	0.087
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	51	0.087
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.086
immune system process	GO:0002376	204	0.085
positive regulation of cell development	GO:0010720	176	0.085
cell projection organization	GO:0030030	302	0.085
carbohydrate homeostasis	GO:0033500	75	0.085
regulation of camp metabolic process	GO:0030814	43	0.085
positive regulation of protein phosphorylation	GO:0001934	135	0.084
regulation of neuron differentiation	GO:0045664	208	0.083
organ regeneration	GO:0031100	101	0.083
cellular response to organic cyclic compound	GO:0071407	202	0.082
ribose phosphate metabolic process	GO:0019693	235	0.082
g protein coupled receptor signaling pathway	GO:0007186	242	0.081
dopamine transport	GO:0015872	18	0.081
regulation of locomotion	GO:0040012	148	0.080
nucleotide metabolic process	GO:0009117	279	0.080
positive regulation of rna metabolic process	GO:0051254	203	0.080
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.079
positive regulation of secretion by cell	GO:1903532	128	0.078
organic anion transport	GO:0015711	132	0.078
response to light stimulus	GO:0009416	52	0.078
regulation of nervous system development	GO:0051960	264	0.078
cellular response to growth factor stimulus	GO:0071363	162	0.077
positive regulation of cellular component organization	GO:0051130	200	0.077
response to calcium ion	GO:0051592	59	0.077
regulation of amine transport	GO:0051952	54	0.076
organic acid metabolic process	GO:0006082	292	0.075
regulation of metal ion transport	GO:0010959	118	0.075
macromolecular complex assembly	GO:0065003	273	0.074
regulation of cyclic nucleotide metabolic process	GO:0030799	51	0.072
positive regulation of cell differentiation	GO:0045597	217	0.072
circulatory system development	GO:0072359	134	0.072
positive regulation of transport	GO:0051050	245	0.070
cell cell signaling	GO:0007267	335	0.069
gland development	GO:0048732	155	0.069
purine nucleotide metabolic process	GO:0006163	229	0.068
neuronal action potential	GO:0019228	35	0.068	Rat
positive regulation of long term synaptic potentiation	GO:1900273	4	0.068
response to cocaine	GO:0042220	39	0.068
signal release	GO:0023061	145	0.068
regulation of synaptic plasticity	GO:0048167	70	0.066
regulation of potassium ion transport	GO:0043266	29	0.065
muscle system process	GO:0003012	115	0.065
ion homeostasis	GO:0050801	212	0.064
positive regulation of multicellular organismal process	GO:0051240	387	0.064	Rat
organophosphate biosynthetic process	GO:0090407	143	0.063
positive regulation of catalytic activity	GO:0043085	184	0.063
single organism catabolic process	GO:0044712	283	0.062
striated muscle contraction	GO:0006941	44	0.062
positive regulation of cyclic nucleotide metabolic process	GO:0030801	37	0.062
sexual reproduction	GO:0019953	148	0.061
positive regulation of protein metabolic process	GO:0051247	178	0.061
regulation of transferase activity	GO:0051338	123	0.061
regulation of hormone secretion	GO:0046883	106	0.060
protein heterooligomerization	GO:0051291	89	0.060
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.059
glucose homeostasis	GO:0042593	75	0.059
wound healing	GO:0042060	122	0.058
regulation of apoptotic process	GO:0042981	335	0.058
ribonucleotide biosynthetic process	GO:0009260	85	0.058
response to monosaccharide	GO:0034284	159	0.057
response to other organism	GO:0051707	220	0.057
negative regulation of phosphate metabolic process	GO:0045936	80	0.056
regeneration	GO:0031099	163	0.056
heart development	GO:0007507	72	0.056
organic hydroxy compound metabolic process	GO:1901615	115	0.056
tissue development	GO:0009888	252	0.056
negative regulation of nervous system development	GO:0051961	79	0.056
response to insulin	GO:0032868	133	0.055
regulation of membrane potential	GO:0042391	110	0.055	Rat
protein localization	GO:0008104	191	0.054
epithelial cell differentiation	GO:0030855	71	0.054
dopamine secretion	GO:0014046	15	0.054
response to toxic substance	GO:0009636	133	0.053
positive regulation of neurogenesis	GO:0050769	165	0.053
negative regulation of apoptotic process	GO:0043066	181	0.053
response to metal ion	GO:0010038	253	0.053
negative regulation of secretion by cell	GO:1903531	72	0.053
regulation of growth	GO:0040008	105	0.052
response to hexose	GO:0009746	144	0.052
amino acid transport	GO:0006865	70	0.051
regulation of mapk cascade	GO:0043408	116	0.051
anatomical structure morphogenesis	GO:0009653	298	0.051	Rat
regulation of nucleotide metabolic process	GO:0006140	117	0.051
biological adhesion	GO:0022610	110	0.049
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.049
response to oxidative stress	GO:0006979	186	0.049
sensory perception of pain	GO:0019233	73	0.049	Rat
regulation of peptide secretion	GO:0002791	82	0.048
neurotransmitter transport	GO:0006836	42	0.048
regulation of purine nucleotide biosynthetic process	GO:1900371	46	0.048
positive regulation of neuron projection development	GO:0010976	99	0.048
positive regulation of neuron differentiation	GO:0045666	126	0.048
calcium ion transport	GO:0006816	131	0.047
myelination	GO:0042552	39	0.046	Rat
defense response	GO:0006952	194	0.046
amine metabolic process	GO:0009308	38	0.046
head development	GO:0060322	247	0.046	Rat
carboxylic acid transport	GO:0046942	115	0.045
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.045
organic substance catabolic process	GO:1901575	316	0.045
cellular response to cytokine stimulus	GO:0071345	127	0.045
desensitization of g protein coupled receptor protein signaling pathway	GO:0002029	10	0.045
growth	GO:0040007	165	0.045
regulation of multicellular organismal development	GO:2000026	376	0.045
positive regulation of protein serine threonine kinase activity	GO:0071902	52	0.044
divalent inorganic cation homeostasis	GO:0072507	165	0.044
peptide hormone secretion	GO:0030072	84	0.044
adenylate cyclase activating g protein coupled receptor signaling pathway	GO:0007189	24	0.044
action potential	GO:0001508	54	0.044	Rat
response to purine containing compound	GO:0014074	126	0.044
positive regulation of molecular function	GO:0044093	230	0.044
regulation of insulin secretion	GO:0050796	65	0.043
camp biosynthetic process	GO:0006171	47	0.043
response to ketone	GO:1901654	182	0.043
regulation of hormone levels	GO:0010817	187	0.043
cellular response to alkaloid	GO:0071312	25	0.043
regulation of response to wounding	GO:1903034	69	0.042
response to organophosphorus	GO:0046683	102	0.042
copulation	GO:0007620	17	0.042
establishment of protein localization	GO:0045184	141	0.042
positive regulation of purine nucleotide biosynthetic process	GO:1900373	36	0.042
programmed cell death	GO:0012501	392	0.041
negative adaptation of signaling pathway	GO:0022401	10	0.041
blood vessel development	GO:0001568	69	0.041
angiogenesis	GO:0001525	53	0.041
ossification	GO:0001503	70	0.041
hormone secretion	GO:0046879	115	0.040
regulation of organelle organization	GO:0033043	80	0.040
regulation of protein kinase activity	GO:0045859	105	0.040
cell type specific apoptotic process	GO:0097285	134	0.040
regulation of neurotransmitter levels	GO:0001505	42	0.040
long term synaptic potentiation	GO:0060291	21	0.039
regulation of muscle system process	GO:0090257	79	0.039	Rat
choline transport	GO:0015871	4	0.039
cellular response to steroid hormone stimulus	GO:0071383	93	0.039
negative regulation of camp biosynthetic process	GO:0030818	12	0.039
neuron fate commitment	GO:0048663	4	0.039
regulation of response to stress	GO:0080134	126	0.039
olfactory learning	GO:0008355	1	0.038
neuron projection development	GO:0031175	273	0.037
cell adhesion	GO:0007155	110	0.037
single organism carbohydrate metabolic process	GO:0044723	118	0.037
cellular response to alcohol	GO:0097306	87	0.037
negative regulation of g protein coupled receptor protein signaling pathway	GO:0045744	15	0.036
cellular amine metabolic process	GO:0044106	38	0.036
phospholipase c activating g protein coupled receptor signaling pathway	GO:0007200	27	0.036
divalent metal ion transport	GO:0070838	132	0.036
positive regulation of synaptic transmission	GO:0050806	62	0.036
response to biotic stimulus	GO:0009607	226	0.036
negative regulation of cellular protein metabolic process	GO:0032269	106	0.036
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.036
response to external biotic stimulus	GO:0043207	221	0.036
regulation of neuron projection development	GO:0010975	161	0.036
negative regulation of cell communication	GO:0010648	158	0.036
response to camp	GO:0051591	91	0.035
female pregnancy	GO:0007565	122	0.035
negative regulation of developmental process	GO:0051093	125	0.035
heart contraction	GO:0060047	57	0.035	Rat
alcohol metabolic process	GO:0006066	77	0.035
leukocyte activation	GO:0045321	76	0.035
immunoglobulin mediated immune response	GO:0016064	4	0.034
positive regulation of transferase activity	GO:0051347	81	0.034
positive regulation of nucleotide biosynthetic process	GO:0030810	36	0.034
regulation of heart contraction	GO:0008016	48	0.034	Rat
renal system process	GO:0003014	40	0.034
regulation of neuron apoptotic process	GO:0043523	83	0.034
locomotion	GO:0040011	237	0.034
circulatory system process	GO:0003013	183	0.034	Rat
single organism biosynthetic process	GO:0044711	342	0.034
phototransduction visible light	GO:0007603	2	0.033
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.033
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.033
detection of visible light	GO:0009584	3	0.033
eye development	GO:0001654	50	0.033
camera type eye development	GO:0043010	48	0.033
positive regulation of cellular amine metabolic process	GO:0033240	3	0.032
positive regulation of cellular protein metabolic process	GO:0032270	167	0.032
neurotransmitter uptake	GO:0001504	3	0.032
organic acid transport	GO:0015849	116	0.032
regulation of map kinase activity	GO:0043405	53	0.032
negative regulation of secretion	GO:0051048	82	0.032
single organism organelle organization	GO:1902589	180	0.031
synapse assembly	GO:0007416	29	0.031
response to bacterium	GO:0009617	200	0.031
regulation of cellular amino acid metabolic process	GO:0006521	2	0.031
regulation of kinase activity	GO:0043549	117	0.031
cellular carbohydrate metabolic process	GO:0044262	72	0.031
sleep	GO:0030431	30	0.031
monocarboxylic acid transport	GO:0015718	52	0.031
regulation of neuron death	GO:1901214	115	0.031
regulation of behavior	GO:0050795	61	0.030
response to amphetamine	GO:0001975	25	0.030
regulation of systemic arterial blood pressure by norepinephrine epinephrine	GO:0001993	2	0.030
response to transition metal nanoparticle	GO:1990267	122	0.030
positive regulation of kinase activity	GO:0033674	77	0.030
positive regulation of secretion	GO:0051047	140	0.030
cellular response to peptide	GO:1901653	133	0.029
sodium ion transmembrane transport	GO:0035725	67	0.029	Mouse Rat
inflammatory response to antigenic stimulus	GO:0002437	18	0.029
positive regulation of cell projection organization	GO:0031346	111	0.029
negative regulation of cyclic nucleotide biosynthetic process	GO:0030803	12	0.029
response to mechanical stimulus	GO:0009612	134	0.029
synaptic transmission dopaminergic	GO:0001963	11	0.029
negative regulation of transcription dna templated	GO:0045892	116	0.028
neuromuscular process	GO:0050905	2	0.028
multicellular organismal signaling	GO:0035637	44	0.028	Rat
negative regulation of cell development	GO:0010721	82	0.027
cellular ketone metabolic process	GO:0042180	51	0.027
cellular response to ammonium ion	GO:0071242	17	0.027
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.027
negative regulation of purine nucleotide metabolic process	GO:1900543	23	0.027
neuron projection morphogenesis	GO:0048812	122	0.027
negative regulation of biosynthetic process	GO:0009890	168	0.027
regulation of cellular amine metabolic process	GO:0033238	8	0.026
regulation of response to external stimulus	GO:0032101	106	0.026
monovalent inorganic cation transport	GO:0015672	172	0.026
peptide transport	GO:0015833	97	0.026
dna metabolic process	GO:0006259	96	0.026
metal ion homeostasis	GO:0055065	186	0.026
developmental growth	GO:0048589	100	0.026
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.026
negative regulation of nucleotide metabolic process	GO:0045980	23	0.026
calcium ion transmembrane transport	GO:0070588	70	0.026
cellular component morphogenesis	GO:0032989	155	0.026
negative regulation of molecular function	GO:0044092	133	0.026
amide transport	GO:0042886	105	0.026
regulation of peptide hormone secretion	GO:0090276	80	0.026
ovulation cycle	GO:0042698	67	0.025
response to glucose	GO:0009749	136	0.025
muscle contraction	GO:0006936	88	0.025
regulation of calcium ion transport	GO:0051924	77	0.025
regulation of blood vessel size	GO:0050880	89	0.025
positive regulation of intracellular signal transduction	GO:1902533	138	0.025
development of primary sexual characteristics	GO:0045137	107	0.025
cellular lipid metabolic process	GO:0044255	208	0.025
cellular amino acid metabolic process	GO:0006520	107	0.025
second messenger mediated signaling	GO:0019932	51	0.025
reproductive system development	GO:0061458	128	0.025
response to molecule of bacterial origin	GO:0002237	194	0.024
positive regulation of dopamine secretion	GO:0033603	8	0.024
regulation of cellular component organization	GO:0051128	368	0.024
skeletal system development	GO:0001501	41	0.024
locomotory exploration behavior	GO:0035641	1	0.024
synaptic transmission glutamatergic	GO:0035249	33	0.024
negative regulation of cellular component organization	GO:0051129	83	0.024
cellular response to peptide hormone stimulus	GO:0071375	120	0.024
regulation of lyase activity	GO:0051339	22	0.024
cellular response to insulin stimulus	GO:0032869	81	0.024
transmission of nerve impulse	GO:0019226	42	0.024	Rat
nerve development	GO:0021675	11	0.024
ensheathment of neurons	GO:0007272	40	0.023	Rat
negative regulation of defecation	GO:2000293	1	0.023
male gamete generation	GO:0048232	99	0.023
negative regulation of neuron differentiation	GO:0045665	62	0.023
response to histamine	GO:0034776	3	0.023
regulation of camp biosynthetic process	GO:0030817	38	0.023
synaptic growth at neuromuscular junction	GO:0051124	1	0.023
divalent inorganic cation transport	GO:0072511	134	0.023
regulation of blood circulation	GO:1903522	110	0.023	Rat
synaptic transmission gabaergic	GO:0051932	22	0.023
response to reactive oxygen species	GO:0000302	120	0.022
cellular response to retinoic acid	GO:0071300	27	0.022
forebrain development	GO:0030900	98	0.022	Rat
cellular response to corticosteroid stimulus	GO:0071384	69	0.022
acid secretion	GO:0046717	48	0.022
g protein coupled glutamate receptor signaling pathway	GO:0007216	8	0.022
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.022
catecholamine metabolic process	GO:0006584	19	0.022
positive regulation of epithelial cell proliferation	GO:0050679	32	0.022	Rat
spermatogenesis	GO:0007283	99	0.022
protein transport	GO:0015031	132	0.022
cellular response to glucose stimulus	GO:0071333	65	0.021
regulation of cellular ketone metabolic process	GO:0010565	27	0.021
carbohydrate derivative catabolic process	GO:1901136	147	0.021
negative regulation of cyclic nucleotide metabolic process	GO:0030800	15	0.021
sensory organ development	GO:0007423	74	0.021
negative regulation of camp metabolic process	GO:0030815	14	0.021
positive regulation of growth	GO:0045927	55	0.021
organ morphogenesis	GO:0009887	75	0.021	Rat
immune response	GO:0006955	104	0.020
negative regulation of protein phosphorylation	GO:0001933	44	0.020
membrane depolarization	GO:0051899	32	0.020
embryonic pattern specification	GO:0009880	1	0.020
regulation of postsynaptic membrane potential	GO:0060078	25	0.020
multicellular organismal movement	GO:0050879	17	0.020

Scn4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
eye and adnexa disease	DOID:1492	0.059
eye disease	DOID:5614	0.059
disease of anatomical entity	DOID:7	0.059	Human
sensory system disease	DOID:0050155	0.059
nervous system disease	DOID:863	0.059
urinary system disease	DOID:18	0.026

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network