Rattus norvegicus

0 known processes

Grem2

gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)

(Aliases: RGD1560008)

Grem2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to oxygen containing compoundGO:19017013860.070
apoptotic processGO:00069153810.067
nucleobase containing small molecule metabolic processGO:00550863160.066
positive regulation of nitrogen compound metabolic processGO:00511733340.063
regulation of apoptotic processGO:00429813350.063
positive regulation of nucleobase containing compound metabolic processGO:00459353190.061
response to extracellular stimulusGO:00099913800.060
response to nutrient levelsGO:00316673700.059
regulation of phosphate metabolic processGO:00192203490.059
regulation of signal transductionGO:00099663180.059
carbohydrate derivative metabolic processGO:19011353460.057
regulation of multicellular organismal developmentGO:20000263760.057
single organism biosynthetic processGO:00447113420.057
protein phosphorylationGO:00064683450.056
organic substance catabolic processGO:19015753160.055
neuron developmentGO:00486662860.055
intracellular signal transductionGO:00355563140.053
nucleotide metabolic processGO:00091172790.052
single organism catabolic processGO:00447122830.052
response to peptide hormoneGO:00434342780.051
transcription dna templatedGO:00063513770.051
cellular response to endogenous stimulusGO:00714953770.051
programmed cell deathGO:00125013920.051
regulation of cell differentiationGO:00455953200.050
cellular component movementGO:00069282480.050
regulation of molecular functionGO:00650093980.050
carboxylic acid metabolic processGO:00197522890.048
cell projection organizationGO:00300303020.048
oxoacid metabolic processGO:00434362900.048
regulation of phosphorus metabolic processGO:00511743490.047
cation transportGO:00068123820.047
regulation of programmed cell deathGO:00430673410.046
organic acid metabolic processGO:00060822920.046
regulation of catalytic activityGO:00507903040.046
response to decreased oxygen levelsGO:00362932370.045
positive regulation of phosphate metabolic processGO:00459372620.045
purine containing compound metabolic processGO:00725212530.044
cell motilityGO:00488702020.044
cellular ketone metabolic processGO:0042180510.044
response to peptideGO:19016522920.044
negative regulation of metabolic processGO:00098923310.044
regulation of protein phosphorylationGO:00019321830.043
ribose phosphate metabolic processGO:00196932350.043
cellular amino acid metabolic processGO:00065201070.043
homeostatic processGO:00425923310.042
neuron projection developmentGO:00311752730.042
regulation of cellular ketone metabolic processGO:0010565270.041
nucleoside phosphate metabolic processGO:00067532830.041
response to inorganic substanceGO:00100353770.040
positive regulation of response to stimulusGO:00485842850.040
inorganic cation transmembrane transportGO:00986622020.040
organophosphate metabolic processGO:00196373700.039
positive regulation of phosphorus metabolic processGO:00105622620.038
positive regulation of catalytic activityGO:00430851840.037
regulation of protein modification processGO:00313991940.036
negative regulation of macromolecule metabolic processGO:00106052600.036
neuron differentiationGO:00301823680.036
ribonucleotide metabolic processGO:00092592310.036
cellular component biogenesisGO:00440853680.036
positive regulation of developmental processGO:00510942830.036
negative regulation of cellular metabolic processGO:00313242810.036
regulation of neurogenesisGO:00507672470.036
positive regulation of multicellular organismal processGO:00512403870.036
cellular amine metabolic processGO:0044106380.036
organonitrogen compound catabolic processGO:19015651790.035
amine metabolic processGO:0009308380.035
response to metal ionGO:00100382530.035
metal ion transportGO:00300012890.035
response to other organismGO:00517072200.035
regulation of cellular component organizationGO:00511283680.035
cellular response to organonitrogen compoundGO:00714171970.035
purine ribonucleotide metabolic processGO:00091502270.035
regulation of neuron differentiationGO:00456642080.035
response to oxygen levelsGO:00704822650.035
catabolic processGO:00090563510.034
chemical homeostasisGO:00488782920.034
regulation of cell developmentGO:00602842630.034
cellular catabolic processGO:00442482950.034
regulation of phosphorylationGO:00423252480.033
positive regulation of cell differentiationGO:00455972170.033
regulation of cellular amino acid metabolic processGO:000652120.033
purine nucleotide metabolic processGO:00061632290.033
regulation of cellular amine metabolic processGO:003323880.033
cellular response to hormone stimulusGO:00328702470.033
cell cell signalingGO:00072673350.032
rna biosynthetic processGO:00327743800.032
neuron apoptotic processGO:0051402880.032
regulation of cell proliferationGO:00421273590.032
rna metabolic processGO:00160704060.032
positive regulation of transportGO:00510502450.032
regulation of neuron projection developmentGO:00109751610.032
regulation of nervous system developmentGO:00519602640.032
glycosyl compound metabolic processGO:19016571820.032
positive regulation of cell proliferationGO:00082842490.031
response to cytokineGO:00340972150.031
regulation of cell projection organizationGO:00313441750.031
response to corticosteroidGO:00319602350.031
cell migrationGO:00164771970.031
agingGO:00075682410.030
nucleic acid templated transcriptionGO:00976593790.030
cell type specific apoptotic processGO:00972851340.030
positive regulation of cellular biosynthetic processGO:00313282950.030
protein complex assemblyGO:00064612630.030
positive regulation of signalingGO:00230562700.030
positive regulation of nervous system developmentGO:00519621780.030
cellular component assemblyGO:00226073600.030
positive regulation of biosynthetic processGO:00098913190.030
regulation of hormone levelsGO:00108171870.029
positive regulation of molecular functionGO:00440932300.029
regulation of nucleic acid templated transcriptionGO:19035063800.029
reproductive processGO:00224143720.029
protein complex biogenesisGO:00702712630.029
response to glucocorticoidGO:00513842230.028
regulation of cell migrationGO:00303341280.028
positive regulation of cell deathGO:00109421840.028
positive regulation of gene expressionGO:00106282440.028
regulation of hydrolase activityGO:00513361430.028
nucleotide catabolic processGO:00091661390.028
response to hypoxiaGO:00016662310.027
nucleoside metabolic processGO:00091161790.027
locomotionGO:00400112370.027
proteolysisGO:00065081750.027
response to bacteriumGO:00096172000.027
regulation of cellular localizationGO:00603412630.027
localization of cellGO:00516742020.027
ion homeostasisGO:00508012120.027
multi organism reproductive processGO:00447032620.026
regulation of cellular protein metabolic processGO:00322682670.026
regulation of transcription dna templatedGO:00063553740.026
regulation of cell motilityGO:20001451310.026
cellular homeostasisGO:00197252520.026
tissue developmentGO:00098882520.026
central nervous system developmentGO:00074173110.026
positive regulation of cellular protein metabolic processGO:00322701670.026
positive regulation of cell projection organizationGO:00313461110.026
transmembrane transportGO:00550854120.026
g protein coupled receptor signaling pathwayGO:00071862420.025
macromolecule localizationGO:00330362520.025
cell projection morphogenesisGO:00488581230.025
response to acid chemicalGO:00011012220.025
regulation of membrane potentialGO:00423911100.025
cellular nitrogen compound catabolic processGO:00442701630.025
cellular response to stressGO:00335542690.025
ion transmembrane transportGO:00342203650.025
reproductionGO:00000032450.025
regulation of system processGO:00440572080.025
cellular response to lipidGO:00713962010.025
cation transmembrane transportGO:00986552630.025
positive regulation of rna metabolic processGO:00512542030.024
negative regulation of multicellular organismal processGO:00512412030.024
lipid metabolic processGO:00066292830.024
metal ion homeostasisGO:00550651860.024
negative regulation of gene expressionGO:00106291990.024
positive regulation of cellular amino acid metabolic processGO:004576410.024
negative regulation of programmed cell deathGO:00430691830.024
positive regulation of cell communicationGO:00106472710.024
neurological system processGO:00508772190.024
response to growth factorGO:00708481890.024
negative regulation of signalingGO:00230571570.024
purine nucleoside metabolic processGO:00422781690.024
protein localizationGO:00081041910.024
nucleoside triphosphate metabolic processGO:00091411440.024
regulation of locomotionGO:00400121480.024
negative regulation of cell communicationGO:00106481580.024
secretionGO:00469033070.024
negative regulation of molecular functionGO:00440921330.023
purine ribonucleotide catabolic processGO:00091541360.023
heterocycle catabolic processGO:00467001670.023
head developmentGO:00603222470.023
organophosphate catabolic processGO:00464341480.023
inflammatory responseGO:00069541500.023
negative regulation of apoptotic processGO:00430661810.023
multicellular organism reproductionGO:00325042330.023
response to nutrientGO:00075842480.023
nucleoside phosphate catabolic processGO:19012921400.023
nitrogen compound transportGO:00717052290.023
purine ribonucleoside metabolic processGO:00461281680.023
protein complex subunit organizationGO:00718223020.023
organic cyclic compound catabolic processGO:19013611750.023
cellular response to peptide hormone stimulusGO:00713751200.023
cellular chemical homeostasisGO:00550822470.023
positive regulation of phosphorylationGO:00423271770.023
cellular cation homeostasisGO:00300031800.023
positive regulation of neurogenesisGO:00507691650.023
regulation of intracellular signal transductionGO:19025312180.022
brain developmentGO:00074202470.022
ribonucleoside metabolic processGO:00091191740.022
positive regulation of cellular amine metabolic processGO:003324030.022
cellular response to nitrogen compoundGO:19016992100.022
regulation of secretion by cellGO:19035302080.022
aromatic compound catabolic processGO:00194391680.022
positive regulation of protein metabolic processGO:00512471780.022
positive regulation of cellular component organizationGO:00511302000.022
regulation of rna metabolic processGO:00512523910.022
positive regulation of secretion by cellGO:19035321280.022
regulation of nucleotide metabolic processGO:00061401170.022
ribonucleoside triphosphate metabolic processGO:00091991410.022
regulation of protein metabolic processGO:00512462890.022
single organism reproductive processGO:00447022970.021
positive regulation of intracellular signal transductionGO:19025331380.021
neuron projection morphogenesisGO:00488121220.021
regulation of neuron apoptotic processGO:0043523830.021
biological adhesionGO:00226101100.021
positive regulation of protein modification processGO:00314011420.021
ribonucleoside catabolic processGO:00424541260.021
anatomical structure morphogenesisGO:00096532980.021
positive regulation of protein phosphorylationGO:00019341350.021
blood circulationGO:00080151830.021
positive regulation of purine nucleotide metabolic processGO:1900544910.021
purine nucleoside catabolic processGO:00061521240.021
nucleoside triphosphate catabolic processGO:00091431230.020
positive regulation of nucleotide metabolic processGO:0045981910.020
cognitionGO:0050890920.020
response to carbohydrateGO:00097431830.020
positive regulation of neuron projection developmentGO:0010976990.020
nucleoside catabolic processGO:00091641260.020
positive regulation of cell developmentGO:00107201760.020
response to temperature stimulusGO:0009266940.020
regulation of catabolic processGO:00098941130.020
gtp catabolic processGO:0006184710.020
positive regulation of rna biosynthetic processGO:19026801970.020
positive regulation of programmed cell deathGO:00430681570.020
cellular ion homeostasisGO:00068731840.020
response to insulinGO:00328681330.020
immune system processGO:00023762040.020
cell morphogenesis involved in neuron differentiationGO:00486671060.020
positive regulation of nucleic acid templated transcriptionGO:19035081970.020
response to ketoneGO:19016541820.019
purine containing compound catabolic processGO:00725231380.019
glycosyl compound catabolic processGO:19016581260.019
multi multicellular organism processGO:00447061380.019
cellular component morphogenesisGO:00329891550.019
synaptic transmissionGO:00072682350.019
cell adhesionGO:00071551100.019
carbohydrate derivative catabolic processGO:19011361470.019
response to woundingGO:00096112540.019
negative regulation of signal transductionGO:0009968830.019
positive regulation of signal transductionGO:00099671750.019
cation homeostasisGO:00550801950.019
regulation of rna biosynthetic processGO:20011413810.019
negative regulation of nitrogen compound metabolic processGO:00511721610.019
macromolecular complex subunit organizationGO:00439333390.019
positive regulation of secretionGO:00510471400.019
response to estrogenGO:00436272320.019
small molecule biosynthetic processGO:00442831240.019
transcription from rna polymerase ii promoterGO:00063662520.019
positive regulation of apoptotic processGO:00430651540.019
purine nucleoside triphosphate metabolic processGO:00091441410.019
purine ribonucleoside catabolic processGO:00461301240.018
response to molecule of bacterial originGO:00022371940.018
response to biotic stimulusGO:00096072260.018
small gtpase mediated signal transductionGO:0007264360.018
cellular calcium ion homeostasisGO:00068741600.018
response to organophosphorusGO:00466831020.018
cell morphogenesis involved in differentiationGO:00009041190.018
secretion by cellGO:00329402480.018
positive regulation of neuron differentiationGO:00456661260.018
regulation of cellular catabolic processGO:00313291010.018
response to radiationGO:00093141370.018
regulation of cell morphogenesis involved in differentiationGO:0010769720.018
regulation of purine nucleotide metabolic processGO:19005421150.018
cardiovascular system developmentGO:00723581340.018
ras protein signal transductionGO:0007265290.018
positive regulation of hydrolase activityGO:0051345860.018
positive regulation of cellular component movementGO:00512721020.018
axon developmentGO:0061564960.018
cellular response to growth factor stimulusGO:00713631620.018
regulation of mapk cascadeGO:00434081160.018
developmental growthGO:00485891000.018
regulation of metal ion transportGO:00109591180.018
positive regulation of transcription dna templatedGO:00458931970.018
calcium ion transportGO:00068161310.018
response to purine containing compoundGO:00140741260.017
hormone metabolic processGO:0042445690.017
oxidation reduction processGO:00551143040.017
regulation of ion transportGO:00432692450.017
anion transportGO:00068201780.017
regulation of secretionGO:00510462240.017
response to external biotic stimulusGO:00432072210.017
multicellular organismal reproductive processGO:00486092330.017
cellular protein localizationGO:00346131220.017
cellular response to peptideGO:19016531330.017
cellular metal ion homeostasisGO:00068751720.017
regenerationGO:00310991630.017
vesicle mediated transportGO:00161921810.017
immune responseGO:00069551040.017
purine nucleoside triphosphate catabolic processGO:00091461220.017
positive regulation of ion transportGO:0043270940.017
response to lipopolysaccharideGO:00324961910.017
single organism carbohydrate metabolic processGO:00447231180.017
growthGO:00400071650.017
guanosine containing compound catabolic processGO:1901069710.017
purine ribonucleoside triphosphate metabolic processGO:00092051400.017
neuron deathGO:00709971270.017
macromolecular complex assemblyGO:00650032730.017
monovalent inorganic cation transportGO:00156721720.017
organelle organizationGO:00069962660.017
positive regulation of macromolecule biosynthetic processGO:00105572470.017
peptidyl amino acid modificationGO:00181931260.017
defense responseGO:00069521940.017
organic anion transportGO:00157111320.016
cell morphogenesisGO:00009021420.016
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.016
regulation of protein kinase activityGO:00458591050.016
cellular macromolecule localizationGO:00707271220.016
establishment of protein localizationGO:00451841410.016
negative regulation of nucleic acid templated transcriptionGO:19035071170.016
ribonucleotide catabolic processGO:00092611360.016
developmental process involved in reproductionGO:00030061590.016
response to oxidative stressGO:00069791860.016
sexual reproductionGO:00199531480.016
purine ribonucleoside triphosphate catabolic processGO:00092071220.016
regulation of cellular component movementGO:00512701500.016
guanosine containing compound metabolic processGO:1901068740.016
cellular response to external stimulusGO:00714961180.016
carbohydrate metabolic processGO:00059751300.016
inorganic ion transmembrane transportGO:00986602290.016
negative regulation of transportGO:00510511360.016
response to hexoseGO:00097461440.016
cell part morphogenesisGO:00329901230.016
circulatory system processGO:00030131830.016
reactive nitrogen species metabolic processGO:200105710.016
intracellular transportGO:00469071850.016
behaviorGO:00076102050.016
nucleobase containing compound catabolic processGO:00346551520.015
vascular process in circulatory systemGO:0003018960.015
organic acid transportGO:00158491160.015
regulation of transcription from rna polymerase ii promoterGO:00063572340.015
negative regulation of cellular protein metabolic processGO:00322691060.015
cellular divalent inorganic cation homeostasisGO:00725031620.015
regulation of transferase activityGO:00513381230.015
rhythmic processGO:00485111560.015
regulation of canonical wnt signaling pathwayGO:006082840.015
regulation of response to stressGO:00801341260.015
regulation of kinase activityGO:00435491170.015
response to vitaminGO:00332731310.015
signal transduction by phosphorylationGO:00230141440.015
divalent inorganic cation homeostasisGO:00725071650.015
purine nucleotide catabolic processGO:00061951360.015
negative regulation of response to stimulusGO:00485851550.015
negative regulation of catalytic activityGO:00430861030.015
protein processingGO:0016485680.015
gtp metabolic processGO:0046039720.015
carboxylic acid transportGO:00469421150.015
regulation of anatomical structure morphogenesisGO:00226031410.015
protein transportGO:00150311320.015
response to hydrogen peroxideGO:0042542890.015
cellular response to oxidative stressGO:0034599760.015
muscle system processGO:00030121150.015
negative regulation of nervous system developmentGO:0051961790.014
negative regulation of cell deathGO:00605482290.014
anterior posterior pattern specificationGO:000995210.014
negative regulation of cellular component organizationGO:0051129830.014
chemotaxisGO:0006935660.014
regulation of neuron deathGO:19012141150.014
circulatory system developmentGO:00723591340.014
divalent metal ion transportGO:00708381320.014
actin filament based processGO:0030029860.014
negative regulation of protein metabolic processGO:00512481140.014
negative regulation of developmental processGO:00510931250.014
positive regulation of cell migrationGO:0030335960.014
positive regulation of gtpase activityGO:0043547470.014
regulation of anatomical structure sizeGO:00900661350.014
regulation of establishment of protein localizationGO:0070201690.014
protein oligomerizationGO:00512591910.014
regulation of cell morphogenesisGO:0022604770.014
regulation of growthGO:00400081050.014
response to transition metal nanoparticleGO:19902671220.014
axis specificationGO:000979840.014
positive regulation of immune system processGO:0002684900.014
regulation of blood circulationGO:19035221100.014
response to reactive oxygen speciesGO:00003021200.014
carbohydrate derivative biosynthetic processGO:19011371240.014
regulation of cellular component biogenesisGO:0044087860.014
cellular response to glucocorticoid stimulusGO:0071385680.013
calcium ion homeostasisGO:00550741620.013
regulation of protein localizationGO:0032880810.013
cell growthGO:00160491040.013
organophosphate biosynthetic processGO:00904071430.013
regulation of purine nucleotide catabolic processGO:0033121650.013
signal releaseGO:00230611450.013
response to estradiolGO:00323551640.013
single organism organelle organizationGO:19025891800.013
positive regulation of protein kinase activityGO:0045860730.013
eye morphogenesisGO:004859240.013
response to toxic substanceGO:00096361330.013
positive regulation of locomotionGO:00400171020.013
cellular hormone metabolic processGO:0034754490.013
response to glucoseGO:00097491360.013
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.013
positive regulation of nucleotide catabolic processGO:0030813530.013
gland developmentGO:00487321550.013
negative regulation of cell proliferationGO:00082851190.013
negative regulation of rna biosynthetic processGO:19026791180.013
cellular response to cytokine stimulusGO:00713451270.013
protein maturationGO:0051604680.013
single organism intracellular transportGO:19025821660.013
response to activityGO:0014823730.013
regulation of cell adhesionGO:0030155520.013
regulation of muscle system processGO:0090257790.013
negative regulation of cellular biosynthetic processGO:00313271610.013
positive regulation of mapk cascadeGO:0043410920.013
appendage morphogenesisGO:003510740.013
amino acid transportGO:0006865700.013
dendrite developmentGO:0016358720.013
positive regulation of cell motilityGO:2000147970.013
regulation of gtpase activityGO:0043087570.012
ribonucleotide biosynthetic processGO:0009260850.012
regulation of gtp catabolic processGO:0033124580.012
limb morphogenesisGO:003510840.012
positive regulation of cellular catabolic processGO:0031331710.012
regulation of synaptic transmissionGO:00508041410.012
multicellular organism growthGO:003526410.012
chemosensory behaviorGO:000763520.012
regulation of proteasomal protein catabolic processGO:006113640.012
sodium ion transportGO:0006814820.012
positive regulation of catabolic processGO:0009896780.012
organic hydroxy compound metabolic processGO:19016151150.012
reproductive structure developmentGO:00486081280.012
cytoskeleton organizationGO:00070101110.012
cytosolic calcium ion homeostasisGO:00514801400.012
response to mechanical stimulusGO:00096121340.012
renal system developmentGO:0072001670.012
regulation of immune system processGO:00026821230.012
multicellular organismal signalingGO:0035637440.012
positive regulation of cytosolic calcium ion concentrationGO:00072041220.012
ribonucleoside triphosphate catabolic processGO:00092031220.012
positive regulation of kinase activityGO:0033674770.012
regulation of tube sizeGO:0035150890.012
lipid biosynthetic processGO:00086101280.012
action potentialGO:0001508540.012
negative regulation of nucleobase containing compound metabolic processGO:00459341530.012
negative regulation of biosynthetic processGO:00098901680.012
negative regulation of transcription dna templatedGO:00458921160.012
alcohol metabolic processGO:0006066770.012
response to alkaloidGO:00432791320.012
wound healingGO:00420601220.012
single organism cellular localizationGO:19025801020.012
cellular response to extracellular stimulusGO:0031668730.012
axonogenesisGO:0007409710.012
cell cycleGO:00070491010.011
transmission of nerve impulseGO:0019226420.011
cellular response to abiotic stimulusGO:0071214850.011
regulation of protein transportGO:0051223680.011
organonitrogen compound biosynthetic processGO:19015661670.011
forebrain developmentGO:0030900980.011
dephosphorylationGO:0016311980.011
olfactory behaviorGO:004204820.011
response to campGO:0051591910.011
embryonic appendage morphogenesisGO:003511340.011
mesoderm developmentGO:000749820.011
negative regulation of macromolecule biosynthetic processGO:00105581480.011
circadian rhythmGO:0007623880.011
cellular response to alcoholGO:0097306870.011
gamete generationGO:00072761240.011
positive regulation of gtp catabolic processGO:0033126480.011
regulation of blood pressureGO:0008217830.011
hormone transportGO:00099141210.011
regulation of protein maturationGO:1903317500.011
negative regulation of phosphate metabolic processGO:0045936800.011
cellular response to molecule of bacterial originGO:0071219560.011
gastrulationGO:000736920.011
membrane organizationGO:0061024940.011
negative regulation of neurogenesisGO:0050768780.011
response to fatty acidGO:0070542650.011
sex differentiationGO:00075481130.011
dna metabolic processGO:0006259960.011
muscle cell proliferationGO:0033002840.011
negative regulation of rna metabolic processGO:00512531230.011
cellular response to reactive oxygen speciesGO:0034614550.011
defense response to gram negative bacteriumGO:005082930.011
cellular response to biotic stimulusGO:0071216590.010
negative regulation of canonical wnt signaling pathwayGO:009009040.010
regulation of nucleoside metabolic processGO:0009118660.010
reactive oxygen species biosynthetic processGO:190340980.010
divalent inorganic cation transportGO:00725111340.010
cytoplasmic transportGO:00164821150.010
negative regulation of phosphorus metabolic processGO:0010563800.010
reactive oxygen species metabolic processGO:0072593370.010
mapk cascadeGO:00001651400.010
peptide secretionGO:0002790860.010
cellular lipid metabolic processGO:00442552080.010
learning or memoryGO:0007611900.010
hormone secretionGO:00468791150.010
reproductive system developmentGO:00614581280.010
regulation of proteolysisGO:0030162660.010
regulation of homeostatic processGO:00328441010.010
response to interleukin 1GO:0070555550.010
monosaccharide metabolic processGO:0005996610.010
cell cycle checkpointGO:000007520.010

Grem2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.023
nervous system diseaseDOID:86300.023
disease of metabolismDOID:001466700.021
central nervous system diseaseDOID:33100.016
inherited metabolic disorderDOID:65500.015
musculoskeletal system diseaseDOID:1700.011