Rattus norvegicus

37 known processes

App

amyloid beta (A4) precursor protein

App biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cell projection organizationGO:00300303020.420
Mouse
vesicle mediated transportGO:00161921810.404
Mouse
regulation of multicellular organismal developmentGO:20000263760.383
Mouse
regulation of intracellular signal transductionGO:19025312180.343
neuron projection developmentGO:00311752730.312
Mouse
ventricular cardiac muscle cell action potentialGO:008600520.279
ion transmembrane transportGO:00342203650.268
response to biotic stimulusGO:00096072260.259
cellular component biogenesisGO:00440853680.256
Mouse
regulation of cellular component organizationGO:00511283680.235
cellular macromolecule localizationGO:00707271220.227
regulation of signal transductionGO:00099663180.226
Mouse
regulation of neuron projection developmentGO:00109751610.213
head developmentGO:00603222470.181
Mouse
potassium ion transportGO:0006813970.170
cell morphogenesisGO:00009021420.167
Mouse
response to bacteriumGO:00096172000.145
regulation of cardiac muscle contractionGO:0055117170.136
cell projection morphogenesisGO:00488581230.135
Mouse
synaptic growth at neuromuscular junctionGO:005112410.128
Mouse
heart morphogenesisGO:000300730.127
regulation of neuron differentiationGO:00456642080.121
Mouse
macromolecular complex assemblyGO:00650032730.117
regulation of vascular endothelial growth factor receptor signaling pathwayGO:003094730.111
establishment of protein localizationGO:00451841410.111
monovalent inorganic cation transportGO:00156721720.111
regulation of molecular functionGO:00650093980.106
positive regulation of cellular component organizationGO:00511302000.106
neuron developmentGO:00486662860.102
Mouse
endocytosisGO:0006897840.099
Mouse
regulation of cardiac muscle cell contractionGO:0086004110.098
negative regulation of organ growthGO:004662130.097
regulation of protein kinase activityGO:00458591050.097
Mouse
auditory receptor cell differentiationGO:004249120.092
cellular potassium ion transportGO:0071804720.092
neurotransmitter secretionGO:0007269330.090
regulation of vesicle mediated transportGO:0060627810.090
positive regulation of nucleobase containing compound metabolic processGO:00459353190.089
Mouse
ion homeostasisGO:00508012120.088
Mouse
regulation of ion transportGO:00432692450.084
cardiac muscle cell action potential involved in contractionGO:008600220.081
negative regulation of neurogenesisGO:0050768780.081
Mouse
histamine secretion involved in inflammatory responseGO:000244130.078
response to external biotic stimulusGO:00432072210.077
protein complex biogenesisGO:00702712630.077
secretion by cellGO:00329402480.076
histamine production involved in inflammatory responseGO:000234930.076
ribonucleoside metabolic processGO:00091191740.074
intracellular protein transportGO:0006886790.073
neuron differentiationGO:00301823680.073
Mouse
organic substance catabolic processGO:19015753160.072
protein complex assemblyGO:00064612630.072
negative regulation of multicellular organismal processGO:00512412030.070
Mouse
synaptic vesicle endocytosisGO:004848840.070
protein transportGO:00150311320.070
defense responseGO:00069521940.069
intracellular signal transductionGO:00355563140.069
protein complex subunit organizationGO:00718223020.068
regulation of potassium ion transportGO:0043266290.068
metal ion transportGO:00300012890.066
inorganic ion transmembrane transportGO:00986602290.066
single organism catabolic processGO:00447122830.066
regulation of cell differentiationGO:00455953200.065
Mouse
cardiac muscle cell contractionGO:0086003100.065
cellular response to abiotic stimulusGO:0071214850.064
lysosomal transportGO:000704180.064
spindle organizationGO:000705120.058
peptidyl tyrosine modificationGO:0018212720.058
Mouse
cellular metal ion homeostasisGO:00068751720.058
Mouse
inorganic cation transmembrane transportGO:00986622020.057
actin filament based processGO:0030029860.056
nucleoside catabolic processGO:00091641260.056
regulation of transferase activityGO:00513381230.056
Mouse
transmembrane transportGO:00550854120.056
signal releaseGO:00230611450.056
single organism organelle organizationGO:19025891800.055
regulation of actin filament based movementGO:1903115120.055
regulation of striated muscle contractionGO:0006942210.054
protein targeting to lysosomeGO:000662220.054
response to molecule of bacterial originGO:00022371940.054
positive regulation of transportGO:00510502450.054
regulation of ion transmembrane transporter activityGO:0032412480.053
regulation of protein phosphorylationGO:00019321830.053
Mouse
positive regulation of multicellular organismal processGO:00512403870.052
catabolic processGO:00090563510.052
actin filament based movementGO:0030048160.052
cellular chemical homeostasisGO:00550822470.051
Mouse
immune responseGO:00069551040.051
regulation of transcription dna templatedGO:00063553740.051
Mouse
response to inorganic substanceGO:00100353770.049
developmental growthGO:00485891000.049
Mouse
negative regulation of epithelial cell proliferationGO:0050680160.048
regulation of cell developmentGO:00602842630.048
Mouse
sodium ion transportGO:0006814820.048
appendage morphogenesisGO:003510740.047
positive regulation of signalingGO:00230562700.047
negative regulation of response to stimulusGO:00485851550.047
neurotransmitter transportGO:0006836420.047
synaptic transmissionGO:00072682350.046
Mouse
neuronal ion channel clusteringGO:004516130.046
positive regulation of response to stimulusGO:00485842850.045
histamine secretion by mast cellGO:000255330.045
cell morphogenesis involved in neuron differentiationGO:00486671060.045
Mouse
regulation of neurogenesisGO:00507672470.044
Mouse
positive regulation of cell developmentGO:00107201760.044
establishment of organelle localizationGO:0051656370.044
inner ear morphogenesisGO:004247210.043
negative regulation of wound healingGO:006104580.043
cytosolic calcium ion homeostasisGO:00514801400.043
cation transportGO:00068123820.042
cellular protein localizationGO:00346131220.042
potassium ion transmembrane transportGO:0071805710.042
regulation of nervous system developmentGO:00519602640.042
Mouse
dendrite morphogenesisGO:0048813430.042
positive regulation of cell projection organizationGO:00313461110.042
positive regulation of protein modification processGO:00314011420.041
regulation of cytoskeleton organizationGO:0051493490.041
response to hypoxiaGO:00016662310.041
regulation of metal ion transportGO:00109591180.040
macromolecular complex subunit organizationGO:00439333390.039
actin cytoskeleton organizationGO:0030036730.039
carbohydrate derivative catabolic processGO:19011361470.038
myeloid leukocyte mediated immunityGO:0002444120.038
organelle organizationGO:00069962660.038
regulation of protein modification processGO:00313991940.038
Mouse
regulation of ion transmembrane transportGO:00347651210.038
response to lipopolysaccharideGO:00324961910.038
regulation of cell projection organizationGO:00313441750.037
regulation of transmembrane transportGO:00347621220.037
response to cytokineGO:00340972150.037
regulation of axonogenesisGO:0050770370.037
regulation of programmed cell deathGO:00430673410.037
cell cell signalingGO:00072673350.037
Mouse
negative regulation of neuron projection developmentGO:0010977460.037
regulation of caveolin mediated endocytosisGO:200128620.036
protein phosphorylationGO:00064683450.036
Mouse
cardiac muscle contractionGO:0060048270.036
cellular catabolic processGO:00442482950.036
positive regulation of signal transductionGO:00099671750.035
cellular response to growth factor stimulusGO:00713631620.035
response to woundingGO:00096112540.034
response to glucocorticoidGO:00513842230.034
cell morphogenesis involved in differentiationGO:00009041190.033
Mouse
positive regulation of hydrolase activityGO:0051345860.033
regulation of cellular amino acid metabolic processGO:000652120.033
positive regulation of neuron projection developmentGO:0010976990.033
neuron projection morphogenesisGO:00488121220.033
Mouse
leukocyte activationGO:0045321760.032
regulation of membrane repolarizationGO:006030610.032
positive regulation of intracellular signal transductionGO:19025331380.032
ras protein signal transductionGO:0007265290.032
regulation of nucleic acid templated transcriptionGO:19035063800.032
Mouse
positive regulation of cell differentiationGO:00455972170.032
negative regulation of cardiac muscle tissue developmentGO:005502630.032
cytoplasmic transportGO:00164821150.032
regulation of growthGO:00400081050.031
Mouse
regulation of ossificationGO:0030278320.031
negative regulation of cellular component organizationGO:0051129830.031
regulation of neurotransmitter levelsGO:0001505420.031
macromolecule localizationGO:00330362520.030
synaptic vesicle localizationGO:0097479240.030
wound healingGO:00420601220.030
circulatory system developmentGO:00723591340.030
response to growth factorGO:00708481890.030
nucleobase containing small molecule metabolic processGO:00550863160.030
positive regulation of nervous system developmentGO:00519621780.030
regulation of transporter activityGO:0032409500.029
regulation of anion transportGO:0044070430.028
negative regulation of nucleic acid templated transcriptionGO:19035071170.028
cellular divalent inorganic cation homeostasisGO:00725031620.028
Mouse
heterocycle catabolic processGO:00467001670.027
regulation of hormone levelsGO:00108171870.027
cellular component morphogenesisGO:00329891550.027
Mouse
positive regulation of neurogenesisGO:00507691650.027
membrane organizationGO:0061024940.026
epithelial cell proliferationGO:0050673540.026
apoptotic processGO:00069153810.025
Human Mouse
regulation of system processGO:00440572080.025
positive regulation of cellular protein metabolic processGO:00322701670.025
response to radiationGO:00093141370.025
Mouse
regulation of phosphorylationGO:00423252480.025
Mouse
nitrogen compound transportGO:00717052290.025
organophosphate metabolic processGO:00196373700.025
brain developmentGO:00074202470.025
Mouse
central nervous system developmentGO:00074173110.025
Mouse
regulation of blood circulationGO:19035221100.024
protein localizationGO:00081041910.024
sexual reproductionGO:00199531480.024
Mouse
regulation of osteoblast differentiationGO:0045667140.024
lysosome localizationGO:0032418100.024
nucleobase containing compound catabolic processGO:00346551520.024
synapse organizationGO:0050808460.024
Mouse
synaptic vesicle transportGO:0048489230.024
purine containing compound metabolic processGO:00725212530.023
negative regulation of transporter activityGO:0032410130.023
embryo implantationGO:0007566150.023
positive regulation of cellular component biogenesisGO:0044089550.023
positive regulation of endocytosisGO:0045807280.023
purine ribonucleotide metabolic processGO:00091502270.023
nucleoside triphosphate catabolic processGO:00091431230.023
vesicle localizationGO:0051648330.023
protein oligomerizationGO:00512591910.023
cellular homeostasisGO:00197252520.022
Mouse
carboxylic acid metabolic processGO:00197522890.022
negative regulation of growthGO:0045926370.022
regulation of muscle contractionGO:0006937530.022
regulation of anatomical structure sizeGO:00900661350.022
negative regulation of cell communicationGO:00106481580.022
response to organophosphorusGO:00466831020.021
regulation of cellular localizationGO:00603412630.021
response to other organismGO:00517072200.021
negative regulation of ion transmembrane transporter activityGO:0032413120.021
negative regulation of cellular biosynthetic processGO:00313271610.021
cellular component movementGO:00069282480.021
Mouse
glycosyl compound metabolic processGO:19016571820.021
response to metal ionGO:00100382530.021
organophosphate catabolic processGO:00464341480.020
multi multicellular organism processGO:00447061380.020
regulation of protein metabolic processGO:00512462890.020
actin mediated cell contractionGO:0070252120.020
circadian rhythmGO:0007623880.020
regulation of muscle system processGO:0090257790.020
cation transmembrane transportGO:00986552630.020
regulation of cellular component biogenesisGO:0044087860.020
programmed cell deathGO:00125013920.020
Human Mouse
negative regulation of nitrogen compound metabolic processGO:00511721610.019
regulation of transmembrane transporter activityGO:0022898490.019
negative regulation of extrinsic apoptotic signaling pathwayGO:200123740.019
neurological system processGO:00508772190.019
Mouse
cellular component assemblyGO:00226073600.019
Mouse
cellular calcium ion homeostasisGO:00068741600.019
Mouse
cell motilityGO:00488702020.019
cellular response to endogenous stimulusGO:00714953770.019
secretionGO:00469033070.018
multicellular organismal signalingGO:0035637440.018
protein homooligomerizationGO:0051260910.018
muscle system processGO:00030121150.018
chemical homeostasisGO:00488782920.018
Mouse
sensory organ developmentGO:0007423740.018
adult locomotory behaviorGO:000834440.018
Mouse
embryonic limb morphogenesisGO:003032640.018
cation homeostasisGO:00550801950.018
Mouse
signal transduction by phosphorylationGO:00230141440.018
anatomical structure morphogenesisGO:00096532980.018
Mouse
purine nucleoside catabolic processGO:00061521240.018
tangential migration from the subventricular zone to the olfactory bulbGO:002202810.018
cardiac muscle tissue growthGO:0055017200.018
female pregnancyGO:00075651220.018
positive regulation of neuron differentiationGO:00456661260.018
organelle localizationGO:0051640550.018
developmental maturationGO:0021700250.018
Mouse
striated muscle tissue developmentGO:0014706580.018
organonitrogen compound catabolic processGO:19015651790.018
regulation of apoptotic processGO:00429813350.017
negative regulation of cardiac muscle cell proliferationGO:006004420.017
positive regulation of caveolin mediated endocytosisGO:200128820.017
positive regulation of cytosolic calcium ion concentrationGO:00072041220.017
regulation of actin filament based processGO:0032970420.017
cell communication by chemical couplingGO:001064320.017
calcium ion homeostasisGO:00550741620.017
Mouse
cellular ketone metabolic processGO:0042180510.017
cell adhesionGO:00071551100.017
regulation of heart contractionGO:0008016480.017
positive regulation of protein metabolic processGO:00512471780.017
ribonucleotide catabolic processGO:00092611360.017
positive regulation of mesenchymal cell proliferationGO:000205340.017
cellular ion homeostasisGO:00068731840.017
Mouse
heart developmentGO:0007507720.017
organic acid metabolic processGO:00060822920.017
response to extracellular stimulusGO:00099913800.017
muscle contractionGO:0006936880.017
action potentialGO:0001508540.017
response to corticosteroidGO:00319602350.016
oxoacid metabolic processGO:00434362900.016
learningGO:0007612330.016
Mouse
regenerationGO:00310991630.016
inner ear developmentGO:0048839210.016
regulation of cell maturationGO:190342930.016
regulation of phosphorus metabolic processGO:00511743490.016
Mouse
regulation of catabolic processGO:00098941130.016
single organism cell adhesionGO:0098602460.016
cardiac conductionGO:006133720.016
carbohydrate phosphorylationGO:0046835160.016
cell cell junction assemblyGO:000704370.016
progesterone receptor signaling pathwayGO:005084710.016
cellular nitrogen compound catabolic processGO:00442701630.016
positive regulation of ion transportGO:0043270940.016
behaviorGO:00076102050.015
Mouse
response to nutrient levelsGO:00316673700.015
negative regulation of cell proliferationGO:00082851190.015
response to peptideGO:19016522920.015
neuron projection extensionGO:1990138260.015
transcription from rna polymerase ii promoterGO:00063662520.015
Mouse
regulation of dendrite developmentGO:0050773590.015
homeostatic processGO:00425923310.015
Mouse
negative regulation of rna metabolic processGO:00512531230.015
carbohydrate derivative metabolic processGO:19011353460.015
nucleotide metabolic processGO:00091172790.015
postnatal olfactory bulb interneuron migrationGO:002182710.015
amine metabolic processGO:0009308380.015
intracellular transportGO:00469071850.015
Mouse
cellular amine metabolic processGO:0044106380.015
response to alkaloidGO:00432791320.015
chromosome segregationGO:000705920.015
muscle tissue developmentGO:0060537580.015
reproductive processGO:00224143720.015
Mouse
regulation of stem cell differentiationGO:200073620.015
learning or memoryGO:0007611900.014
Mouse
negative regulation of rna biosynthetic processGO:19026791180.014
ribonucleoside triphosphate catabolic processGO:00092031220.014
regulation of protein catabolic processGO:0042176160.014
negative regulation of transportGO:00510511360.014
dendrite developmentGO:0016358720.014
Mouse
establishment of vesicle localizationGO:0051650310.014
cell activationGO:0001775970.014
myeloid cell activation involved in immune responseGO:0002275130.014
cellular response to external stimulusGO:00714961180.014
negative regulation of cardiac muscle tissue growthGO:005502230.014
regulation of membrane potentialGO:00423911100.014
rna metabolic processGO:00160704060.014
Mouse
cell junction organizationGO:0034330210.014
respiratory system developmentGO:0060541450.014
positive regulation of transferase activityGO:0051347810.014
regulation of nucleotide metabolic processGO:00061401170.014
regulation of cell morphogenesis involved in differentiationGO:0010769720.014
hormone secretionGO:00468791150.014
calcium ion transportGO:00068161310.014
regulation of establishment of protein localizationGO:0070201690.014
neuromuscular synaptic transmissionGO:000727420.014
sulfur amino acid metabolic processGO:000009690.014
nerve developmentGO:0021675110.014
ribonucleotide metabolic processGO:00092592310.013
cell junction assemblyGO:0034329180.013
response to carbohydrateGO:00097431830.013
peptidyl tyrosine phosphorylationGO:0018108720.013
Mouse
regulation of cellular response to growth factor stimulusGO:0090287150.013
sister chromatid segregationGO:000081910.013
organic cyclic compound catabolic processGO:19013611750.013
positive regulation of cell communicationGO:00106472710.013
transmission of nerve impulseGO:0019226420.013
purine nucleotide catabolic processGO:00061951360.013
positive regulation of rab gtpase activityGO:003285130.013
nucleoside phosphate metabolic processGO:00067532830.013
negative regulation of developmental processGO:00510931250.013
Mouse
enzyme linked receptor protein signaling pathwayGO:00071671160.013
Mouse
germ cell migrationGO:000835410.013
cellular macromolecular complex assemblyGO:0034622580.013
response to transition metal nanoparticleGO:19902671220.013
single organism intracellular transportGO:19025821660.013
Mouse
olfactory bulb interneuron developmentGO:002189110.013
negative regulation of biosynthetic processGO:00098901680.013
regulation of protein complex assemblyGO:0043254330.013
positive regulation of developmental processGO:00510942830.012
defense response to gram negative bacteriumGO:005082930.012
protein catabolic processGO:0030163300.012
inner ear receptor cell differentiationGO:006011320.012
locomotionGO:00400112370.012
Mouse
glial cell differentiationGO:0010001650.012
negative regulation of gene expressionGO:00106291990.012
Human
regulation of proteasomal protein catabolic processGO:006113640.012
cell cycleGO:00070491010.012
Mouse
olfactory bulb interneuron differentiationGO:002188910.012
vascular process in circulatory systemGO:0003018960.012
regulation of response to stressGO:00801341260.012
regulation of sensory perceptionGO:0051931290.012
regulation of kinase activityGO:00435491170.012
Mouse
response to phGO:0009268270.012
establishment of synaptic vesicle localizationGO:0097480230.012
regulation of synaptic growth at neuromuscular junctionGO:000858210.012
cellular cation homeostasisGO:00300031800.012
Mouse
cellular response to mechanical stimulusGO:0071260480.012
developmental inductionGO:003112820.012
embryo developmentGO:0009790490.012
mast cell migrationGO:009753140.012
negative regulation of macromolecule metabolic processGO:00106052600.012
Human
negative regulation of osteoblast differentiationGO:004566820.012
sensory perceptionGO:00076001010.012
sequestering of calcium ionGO:005120880.012
glucose homeostasisGO:0042593750.012
nucleotide catabolic processGO:00091661390.012
regulation of secretionGO:00510462240.012
cerebral cortex tangential migrationGO:002180010.012
regulation of cellular ketone metabolic processGO:0010565270.012
negative regulation of heart growthGO:006111730.012
response to nicotineGO:0035094510.011
substrate dependent cerebral cortex tangential migrationGO:002182510.011
growthGO:00400071650.011
Mouse
negative regulation of cell projection organizationGO:0031345500.011
regulation of map kinase activityGO:0043405530.011
regulation of ion homeostasisGO:2000021630.011
protein modification by small protein conjugation or removalGO:0070647350.011
negative regulation of cell cycle phase transitionGO:190198840.011
mast cell activationGO:0045576150.011
regulation of cardiac muscle tissue developmentGO:0055024120.011
regulation of rna biosynthetic processGO:20011413810.011
Mouse
positive regulation of catalytic activityGO:00430851840.011
myeloid leukocyte activationGO:0002274360.011
glycosyl compound catabolic processGO:19016581260.011
divalent inorganic cation transportGO:00725111340.011
regulated secretory pathwayGO:0045055170.011
small gtpase mediated signal transductionGO:0007264360.011
single organism biosynthetic processGO:00447113420.011
histone modificationGO:0016570300.011
inflammatory responseGO:00069541500.011
regulation of blood pressureGO:0008217830.011
production of molecular mediator involved in inflammatory responseGO:000253250.011
cellular response to oxygen containing compoundGO:19017013860.011
response to axon injuryGO:0048678590.011
melanosome localizationGO:003240010.011
negative regulation of molecular functionGO:00440921330.011
Human
axon extensionGO:0048675260.011
hair cell differentiationGO:003531520.011
divalent metal ion transportGO:00708381320.011
positive regulation of cellular amine metabolic processGO:003324030.011
forebrain neuron developmentGO:002188430.011
cellular response to lipidGO:00713962010.011
sulfur compound biosynthetic processGO:0044272190.011
cardiac muscle cell action potentialGO:008600150.011
cellular response to organic cyclic compoundGO:00714072020.011
embryonic pattern specificationGO:000988010.011
epithelial cell differentiationGO:0030855710.010
cellular sodium ion homeostasisGO:000688340.010
purine nucleoside triphosphate metabolic processGO:00091441410.010
lymphocyte activationGO:0046649430.010
positive regulation of protein kinase activityGO:0045860730.010
negative regulation of potassium ion transportGO:0043267110.010
agingGO:00075682410.010
positive regulation of cell proliferationGO:00082842490.010
purine containing compound catabolic processGO:00725231380.010
cellular response to inorganic substanceGO:0071241650.010
negative regulation of mitotic cell cycle phase transitionGO:190199130.010
cell fate determinationGO:000170920.010
gastrulationGO:000736920.010
regulation of epithelial cell proliferationGO:0050678490.010
response to purine containing compoundGO:00140741260.010
metal ion homeostasisGO:00550651860.010
Mouse

App disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.188
Human
nervous system diseaseDOID:86300.188
Human
central nervous system diseaseDOID:33100.058
Human
brain diseaseDOID:93600.048
electroclinical syndromeDOID:005070100.048
epilepsy syndromeDOID:182600.048
neonatal period electroclinical syndromeDOID:005070200.048
musculoskeletal system diseaseDOID:1700.019
connective tissue diseaseDOID:6500.016
ohtahara syndromeDOID:005070900.015
hematopoietic system diseaseDOID:7400.011
immune system diseaseDOID:291400.011