IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

C4bpb

complement component 4 binding protein, beta

(Aliases: C4bp-ps1,MGC108727)

Ensembl: ENSRNOG00000004125
Entrez: 24236
RGD: 2236
UniProtKB: A0A5C5

Process Predictions
Disease Predictions

C4bpb biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to extracellular stimulus	GO:0009991	380	0.358
regulation of nervous system development	GO:0051960	264	0.227
protein maturation	GO:0051604	68	0.211	Human
regulation of catalytic activity	GO:0050790	304	0.186
regulation of programmed cell death	GO:0043067	341	0.181
positive regulation of multicellular organismal process	GO:0051240	387	0.177
response to nutrient	GO:0007584	248	0.137
regulation of phosphorus metabolic process	GO:0051174	349	0.124
intracellular signal transduction	GO:0035556	314	0.118
response to nutrient levels	GO:0031667	370	0.118
response to metal ion	GO:0010038	253	0.095
single organism biosynthetic process	GO:0044711	342	0.095
regulation of molecular function	GO:0065009	398	0.089
negative regulation of programmed cell death	GO:0043069	183	0.086
programmed cell death	GO:0012501	392	0.085
regulation of serine type endopeptidase activity	GO:1900003	1	0.085
negative regulation of serine type endopeptidase activity	GO:1900004	1	0.084
negative regulation of cell death	GO:0060548	229	0.079
positive regulation of nervous system development	GO:0051962	178	0.070
multi organism reproductive process	GO:0044703	262	0.070
reproduction	GO:0000003	245	0.069
regulation of serine type peptidase activity	GO:1902571	1	0.069
lipid biosynthetic process	GO:0008610	128	0.069
regulation of hydrolase activity	GO:0051336	143	0.069
positive regulation of response to stimulus	GO:0048584	285	0.068	Human
negative regulation of gene expression	GO:0010629	199	0.067	Human
negative regulation of macromolecule metabolic process	GO:0010605	260	0.066	Human
apoptotic process	GO:0006915	381	0.066
amide biosynthetic process	GO:0043604	10	0.065
regulation of neuron differentiation	GO:0045664	208	0.065
cellular response to endogenous stimulus	GO:0071495	377	0.064
reproductive process	GO:0022414	372	0.061
regulation of cell proliferation	GO:0042127	359	0.061
negative regulation of metabolic process	GO:0009892	331	0.060	Human
protein processing	GO:0016485	68	0.059	Human
cellular amino acid metabolic process	GO:0006520	107	0.059
protein activation cascade	GO:0072376	12	0.059	Human
cellular amine metabolic process	GO:0044106	38	0.059
response to peptide hormone	GO:0043434	278	0.059
regulation of response to stress	GO:0080134	126	0.058	Human
growth	GO:0040007	165	0.057
positive regulation of developmental process	GO:0051094	283	0.056
defense response	GO:0006952	194	0.056	Human
regulation of protein metabolic process	GO:0051246	289	0.055	Human
regulation of neuron projection development	GO:0010975	161	0.053
response to decreased oxygen levels	GO:0036293	237	0.053
ion homeostasis	GO:0050801	212	0.053
response to peptide	GO:1901652	292	0.053
multicellular organism reproduction	GO:0032504	233	0.050
regulation of system process	GO:0044057	208	0.050
regulation of apoptotic process	GO:0042981	335	0.048
carboxylic acid metabolic process	GO:0019752	289	0.048
wound healing	GO:0042060	122	0.047
positive regulation of transport	GO:0051050	245	0.047
positive regulation of protein metabolic process	GO:0051247	178	0.047	Human
regulation of protein phosphorylation	GO:0001932	183	0.047
regulation of neurogenesis	GO:0050767	247	0.047
regulation of cellular localization	GO:0060341	263	0.047
cellular ketone metabolic process	GO:0042180	51	0.046
response to acid chemical	GO:0001101	222	0.046
cellular response to organonitrogen compound	GO:0071417	197	0.046
immune response	GO:0006955	104	0.046	Human
response to biotic stimulus	GO:0009607	226	0.045
regulation of protein processing	GO:0070613	50	0.045	Human
lipid transport	GO:0006869	61	0.044
response to hexose	GO:0009746	144	0.044
negative regulation of response to stimulus	GO:0048585	155	0.044	Human
macromolecule localization	GO:0033036	252	0.044
regulation of multicellular organismal development	GO:2000026	376	0.044
response to estrogen	GO:0043627	232	0.042
response to cytokine	GO:0034097	215	0.042
lipid metabolic process	GO:0006629	283	0.042
regulation of cellular ketone metabolic process	GO:0010565	27	0.041
cellular lipid metabolic process	GO:0044255	208	0.041
negative regulation of protein maturation	GO:1903318	47	0.040	Human
regulation of hormone levels	GO:0010817	187	0.040
circulatory system process	GO:0003013	183	0.040
cellular chemical homeostasis	GO:0055082	247	0.040
metal ion homeostasis	GO:0055065	186	0.039
regulation of phosphate metabolic process	GO:0019220	349	0.039
positive regulation of phosphate metabolic process	GO:0045937	262	0.039
blood circulation	GO:0008015	183	0.038
steroid biosynthetic process	GO:0006694	48	0.037
negative regulation of apoptotic process	GO:0043066	181	0.037
lipid localization	GO:0010876	62	0.037
negative regulation of signaling	GO:0023057	157	0.037
positive regulation of intracellular signal transduction	GO:1902533	138	0.037
regulation of cellular protein metabolic process	GO:0032268	267	0.036
proteolysis	GO:0006508	175	0.036
regulation of phosphorylation	GO:0042325	248	0.036
regulation of response to wounding	GO:1903034	69	0.035	Human
regulation of signal transduction	GO:0009966	318	0.035
regeneration	GO:0031099	163	0.034
single organism reproductive process	GO:0044702	297	0.034
cellular component assembly	GO:0022607	360	0.034
protein phosphorylation	GO:0006468	345	0.034
cellular response to oxygen containing compound	GO:1901701	386	0.034
positive regulation of phosphorylation	GO:0042327	177	0.034
response to camp	GO:0051591	91	0.034
amine metabolic process	GO:0009308	38	0.033
organic acid metabolic process	GO:0006082	292	0.033
response to ethanol	GO:0045471	162	0.033
cellular ion homeostasis	GO:0006873	184	0.033
response to ketone	GO:1901654	182	0.032
organophosphate metabolic process	GO:0019637	370	0.032
oxoacid metabolic process	GO:0043436	290	0.032
regulation of heterotypic cell cell adhesion	GO:0034114	2	0.032
organonitrogen compound biosynthetic process	GO:1901566	167	0.032
heterotypic cell cell adhesion	GO:0034113	2	0.032
neurological system process involved in regulation of systemic arterial blood pressure	GO:0001976	3	0.032
response to vitamin	GO:0033273	131	0.031
positive regulation of phosphorus metabolic process	GO:0010562	262	0.031
homeostatic process	GO:0042592	331	0.031
nucleobase containing small molecule metabolic process	GO:0055086	316	0.031
fibrinolysis	GO:0042730	2	0.031
negative regulation of molecular function	GO:0044092	133	0.031
positive regulation of signaling	GO:0023056	270	0.031
cell projection organization	GO:0030030	302	0.031
response to glucocorticoid	GO:0051384	223	0.031
epithelial cell proliferation	GO:0050673	54	0.030
response to bacterium	GO:0009617	200	0.030
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.030
regulation of homeostatic process	GO:0032844	101	0.030
positive regulation of neurogenesis	GO:0050769	165	0.030
negative regulation of cellular metabolic process	GO:0031324	281	0.029
feeding behavior	GO:0007631	53	0.029
exocytosis	GO:0006887	60	0.029
peptidyl tyrosine phosphorylation	GO:0018108	72	0.029
neuron differentiation	GO:0030182	368	0.029
cellular cation homeostasis	GO:0030003	180	0.029
cellular homeostasis	GO:0019725	252	0.029
divalent metal ion transport	GO:0070838	132	0.028
positive regulation of gene expression	GO:0010628	244	0.028
regulation of intracellular signal transduction	GO:1902531	218	0.028
response to radiation	GO:0009314	137	0.028
positive regulation of neuron differentiation	GO:0045666	126	0.027
regulation of protein modification process	GO:0031399	194	0.027
negative regulation of serine type peptidase activity	GO:1902572	1	0.027
signal transduction by phosphorylation	GO:0023014	144	0.027
positive regulation of catalytic activity	GO:0043085	184	0.026
regulation of cellular amine metabolic process	GO:0033238	8	0.026
biological adhesion	GO:0022610	110	0.026
positive regulation of cellular amine metabolic process	GO:0033240	3	0.026
regulation of ion transport	GO:0043269	245	0.026
chemical homeostasis	GO:0048878	292	0.026
negative regulation of proteolysis	GO:0045861	41	0.026
detection of visible light	GO:0009584	3	0.025
positive regulation of cellular biosynthetic process	GO:0031328	295	0.025
protein complex biogenesis	GO:0070271	263	0.025
regulation of cell projection organization	GO:0031344	175	0.025
carbohydrate derivative biosynthetic process	GO:1901137	124	0.025
negative regulation of endopeptidase activity	GO:0010951	36	0.025
organic acid biosynthetic process	GO:0016053	83	0.025
negative regulation of peptidase activity	GO:0010466	38	0.025
response to fatty acid	GO:0070542	65	0.025
regulation of cell differentiation	GO:0045595	320	0.025
positive regulation of immune system process	GO:0002684	90	0.025	Human
response to glucose	GO:0009749	136	0.024
cellular component biogenesis	GO:0044085	368	0.024
positive regulation of cell differentiation	GO:0045597	217	0.024
response to inorganic substance	GO:0010035	377	0.024
nucleoside phosphate metabolic process	GO:0006753	283	0.024
calcium ion transport	GO:0006816	131	0.024
immune system process	GO:0002376	204	0.024	Human
negative regulation of cellular protein metabolic process	GO:0032269	106	0.023
peptidyl amino acid modification	GO:0018193	126	0.023
regulation of growth	GO:0040008	105	0.023
regulation of cell growth	GO:0001558	85	0.023
cytolysis	GO:0019835	4	0.023
coagulation	GO:0050817	28	0.023
hormone metabolic process	GO:0042445	69	0.022
cellular response to nitrogen compound	GO:1901699	210	0.022
negative regulation of catalytic activity	GO:0043086	103	0.022
macromolecular complex assembly	GO:0065003	273	0.022
response to transition metal nanoparticle	GO:1990267	122	0.022
response to hypoxia	GO:0001666	231	0.022
regulation of response to external stimulus	GO:0032101	106	0.022	Human
regulation of endothelial cell apoptotic process	GO:2000351	3	0.022
carboxylic acid biosynthetic process	GO:0046394	83	0.021
regulation of anatomical structure size	GO:0090066	135	0.021
regulation of secretion	GO:0051046	224	0.021
regulation of lipid biosynthetic process	GO:0046890	38	0.021
cellular response to peptide hormone stimulus	GO:0071375	120	0.021
glycerolipid metabolic process	GO:0046486	67	0.021
regulation of metal ion transport	GO:0010959	118	0.021
anion transport	GO:0006820	178	0.021
response to external biotic stimulus	GO:0043207	221	0.021
protein complex assembly	GO:0006461	263	0.021
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.020
peptidyl tyrosine modification	GO:0018212	72	0.020
monocarboxylic acid metabolic process	GO:0032787	152	0.020
positive regulation of extracellular matrix organization	GO:1903055	4	0.020
response to carbohydrate	GO:0009743	183	0.020
negative regulation of signal transduction	GO:0009968	83	0.020
response to other organism	GO:0051707	220	0.019
organ regeneration	GO:0031100	101	0.019
cellular response to external stimulus	GO:0071496	118	0.019
positive regulation of biosynthetic process	GO:0009891	319	0.019
transmission of nerve impulse	GO:0019226	42	0.019
response to insulin	GO:0032868	133	0.019
positive regulation of protein modification process	GO:0031401	142	0.019
extracellular matrix constituent secretion	GO:0070278	4	0.019
purine containing compound metabolic process	GO:0072521	253	0.019
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.018
gland development	GO:0048732	155	0.018
regulation of cellular amino acid metabolic process	GO:0006521	2	0.018
regulation of cellular component organization	GO:0051128	368	0.018
negative regulation of cell communication	GO:0010648	158	0.018
multicellular organismal reproductive process	GO:0048609	233	0.018
regulation of cell development	GO:0060284	263	0.018
heart morphogenesis	GO:0003007	3	0.018
tissue development	GO:0009888	252	0.018
regulation of secretion by cell	GO:1903530	208	0.018
single organism catabolic process	GO:0044712	283	0.018
positive regulation of cell development	GO:0010720	176	0.018
glucose homeostasis	GO:0042593	75	0.017
neuron development	GO:0048666	286	0.017
organic substance catabolic process	GO:1901575	316	0.017	Human
positive regulation of homeostatic process	GO:0032846	49	0.017
cell cell signaling	GO:0007267	335	0.017
circadian rhythm	GO:0007623	88	0.017
cell type specific apoptotic process	GO:0097285	134	0.017
positive regulation of cell proliferation	GO:0008284	249	0.017
intracellular transport	GO:0046907	185	0.017
cardiac chamber development	GO:0003205	1	0.017
carbohydrate derivative metabolic process	GO:1901135	346	0.016
amide transport	GO:0042886	105	0.016
positive regulation of cellular protein metabolic process	GO:0032270	167	0.016
catenin import into nucleus	GO:0035411	1	0.016
sexual reproduction	GO:0019953	148	0.016
response to purine containing compound	GO:0014074	126	0.016
alcohol metabolic process	GO:0006066	77	0.016
regulation of body fluid levels	GO:0050878	90	0.016
response to oxygen levels	GO:0070482	265	0.016
cation homeostasis	GO:0055080	195	0.016
regulation of renal sodium excretion	GO:0035813	20	0.016
small molecule biosynthetic process	GO:0044283	124	0.016
cellular response to hormone stimulus	GO:0032870	247	0.016
regulation of protein maturation	GO:1903317	50	0.016	Human
cell growth	GO:0016049	104	0.016
single organism cellular localization	GO:1902580	102	0.016
negative regulation of protein metabolic process	GO:0051248	114	0.015	Human
negative regulation of protein processing	GO:0010955	47	0.015	Human
g protein coupled receptor signaling pathway	GO:0007186	242	0.015
developmental growth	GO:0048589	100	0.015
regulation of neuron death	GO:1901214	115	0.015
cellular amide metabolic process	GO:0043603	44	0.015
response to corticosteroid	GO:0031960	235	0.015
hormone transport	GO:0009914	121	0.015
regulation of peptidase activity	GO:0052547	55	0.015
organic hydroxy compound transport	GO:0015850	77	0.015
regulation of ion homeostasis	GO:2000021	63	0.015
brain renin angiotensin system	GO:0002035	3	0.015
response to activity	GO:0014823	73	0.014
stress activated protein kinase signaling cascade	GO:0031098	37	0.014
regulation of catabolic process	GO:0009894	113	0.014	Human
positive regulation of heterotypic cell cell adhesion	GO:0034116	1	0.014
response to monosaccharide	GO:0034284	159	0.014
positive regulation of hydrolase activity	GO:0051345	86	0.014
regulation of proteolysis	GO:0030162	66	0.014
positive regulation of blood circulation	GO:1903524	65	0.014
regulation of lipid metabolic process	GO:0019216	68	0.014
inflammatory response	GO:0006954	150	0.014	Human
response to vitamin b6	GO:0034516	1	0.014
ion transmembrane transport	GO:0034220	365	0.014
sulfur compound metabolic process	GO:0006790	70	0.014
regulation of vesicle mediated transport	GO:0060627	81	0.014
secretion	GO:0046903	307	0.014
nucleotide metabolic process	GO:0009117	279	0.014
complement activation	GO:0006956	11	0.014	Human
cellular response to stress	GO:0033554	269	0.014
positive regulation of cellular component organization	GO:0051130	200	0.013
neurological system process	GO:0050877	219	0.013
sequestering of metal ion	GO:0051238	9	0.013
purine nucleotide metabolic process	GO:0006163	229	0.013
regulation of inflammatory response	GO:0050727	48	0.013	Human
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.013
regulation of endopeptidase activity	GO:0052548	51	0.013
acute inflammatory response	GO:0002526	58	0.013	Human
small molecule catabolic process	GO:0044282	59	0.013
regulation of muscle system process	GO:0090257	79	0.013
monocarboxylic acid biosynthetic process	GO:0072330	48	0.013
organic hydroxy compound metabolic process	GO:1901615	115	0.013
cellular response to organic cyclic compound	GO:0071407	202	0.013
vesicle mediated transport	GO:0016192	181	0.013
regulation of blood circulation	GO:1903522	110	0.013
negative regulation of multicellular organismal process	GO:0051241	203	0.013
ribose phosphate metabolic process	GO:0019693	235	0.013
cell adhesion	GO:0007155	110	0.013
regulation of calcium ion transport	GO:0051924	77	0.013
protein complex subunit organization	GO:0071822	302	0.013
negative regulation of neuron death	GO:1901215	69	0.013
hemostasis	GO:0007599	26	0.013
response to estradiol	GO:0032355	164	0.012
response to wounding	GO:0009611	254	0.012	Human
monocarboxylic acid transport	GO:0015718	52	0.012
divalent inorganic cation transport	GO:0072511	134	0.012
axis specification	GO:0009798	4	0.012
positive regulation of neuron projection development	GO:0010976	99	0.012
leukocyte mediated immunity	GO:0002443	28	0.012	Human
cardiovascular system development	GO:0072358	134	0.012
cell activation	GO:0001775	97	0.012
adult locomotory behavior	GO:0008344	4	0.012
negative regulation of hydrolase activity	GO:0051346	52	0.012
organophosphate biosynthetic process	GO:0090407	143	0.012
spermatogenesis	GO:0007283	99	0.012
liver development	GO:0001889	90	0.012
cardiac ventricle development	GO:0003231	1	0.012
positive regulation of molecular function	GO:0044093	230	0.012
cellular response to hexose stimulus	GO:0071331	65	0.011
plasminogen activation	GO:0031639	2	0.011
peptide transport	GO:0015833	97	0.011
secretion by cell	GO:0032940	248	0.011
fertilization	GO:0009566	3	0.011
rhythmic process	GO:0048511	156	0.011
positive regulation of cell death	GO:0010942	184	0.011
divalent inorganic cation homeostasis	GO:0072507	165	0.011
response to acetate	GO:0010034	3	0.011
single organism intracellular transport	GO:1902582	166	0.011
positive regulation of lipid biosynthetic process	GO:0046889	25	0.011
regulation of transmembrane transport	GO:0034762	122	0.011
regulation of blood pressure	GO:0008217	83	0.011
protein transport	GO:0015031	132	0.011
anterior posterior pattern specification	GO:0009952	1	0.011
nucleotide biosynthetic process	GO:0009165	98	0.011
vascular process in circulatory system	GO:0003018	96	0.011
purine containing compound biosynthetic process	GO:0072522	85	0.011
cellular response to abiotic stimulus	GO:0071214	85	0.011
cellular metal ion homeostasis	GO:0006875	172	0.011
response to light stimulus	GO:0009416	52	0.011
muscle contraction	GO:0006936	88	0.011
renal sodium excretion	GO:0035812	20	0.011
regulation of tube size	GO:0035150	89	0.011
cytoplasmic transport	GO:0016482	115	0.011
macromolecular complex subunit organization	GO:0043933	339	0.010
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.010
carbohydrate homeostasis	GO:0033500	75	0.010
multicellular organismal signaling	GO:0035637	44	0.010
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.010
endothelial cell apoptotic process	GO:0072577	3	0.010
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.010
organic anion transport	GO:0015711	132	0.010
cellular biogenic amine metabolic process	GO:0006576	30	0.010

C4bpb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.040
hematopoietic system disease	DOID:74	0.040
blood coagulation disease	DOID:1247	0.040
immune system disease	DOID:2914	0.040
inherited blood coagulation disease	DOID:2214	0.040
eye disease	DOID:5614	0.039
nervous system disease	DOID:863	0.039
eye and adnexa disease	DOID:1492	0.039
sensory system disease	DOID:0050155	0.039
cardiovascular system disease	DOID:1287	0.028
muscle tissue disease	DOID:66	0.022
musculoskeletal system disease	DOID:17	0.022
myopathy	DOID:423	0.022
muscular disease	DOID:0080000	0.022
disease of metabolism	DOID:0014667	0.020
retinal disease	DOID:5679	0.017
acquired metabolic disease	DOID:0060158	0.012

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