Rattus norvegicus

61 known processes

Kynu

kynureninase (L-kynurenine hydrolase)

Kynu biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
oxoacid metabolic processGO:00434362900.563
carboxylic acid metabolic processGO:00197522890.424
organic acid metabolic processGO:00060822920.389
hormone transportGO:00099141210.389
response to nutrient levelsGO:00316673700.353
aromatic amino acid family catabolic processGO:000907470.290
glutathione transportGO:003463520.283
anion transportGO:00068201780.262
establishment or maintenance of transmembrane electrochemical gradientGO:001024810.249
response to peptide hormoneGO:00434342780.249
protein complex assemblyGO:00064612630.236
ion transmembrane transportGO:00342203650.224
regulation of metal ion transportGO:00109591180.224
drug transmembrane transportGO:0006855130.206
cellular response to cytokine stimulusGO:00713451270.203
regulation of cellular localizationGO:00603412630.197
small molecule biosynthetic processGO:00442831240.192
alcohol metabolic processGO:0006066770.191
glycerolipid metabolic processGO:0046486670.185
response to extracellular stimulusGO:00099913800.165
purine containing compound metabolic processGO:00725212530.164
positive regulation of multicellular organismal processGO:00512403870.162
organonitrogen compound biosynthetic processGO:19015661670.162
transmembrane transportGO:00550854120.161
regulation of hormone levelsGO:00108171870.160
oligopeptide transportGO:000685740.154
carnitine transportGO:001587910.147
positive regulation of transportGO:00510502450.145
regulation of secretion by cellGO:19035302080.141
aromatic amino acid family metabolic processGO:000907290.140
alpha amino acid metabolic processGO:1901605710.136
immune responseGO:00069551040.131
innate immune responseGO:0045087350.130
secretionGO:00469033070.127
response to transition metal nanoparticleGO:19902671220.126
monocarboxylic acid transportGO:0015718520.125
homeostatic processGO:00425923310.122
organophosphate metabolic processGO:00196373700.121
cellular response to endogenous stimulusGO:00714953770.120
catabolic processGO:00090563510.120
protein complex subunit organizationGO:00718223020.118
macromolecular complex assemblyGO:00650032730.118
epinephrine transportGO:004824170.117
metal ion transportGO:00300012890.117
cellular response to nitrogen compoundGO:19016992100.115
negative regulation of serine type peptidase activityGO:190257210.114
single organism biosynthetic processGO:00447113420.114
response to molecule of fungal originGO:000223830.114
cellular lipid metabolic processGO:00442552080.113
carboxylic acid transportGO:00469421150.113
response to other organismGO:00517072200.111
chemical homeostasisGO:00488782920.107
reproductive processGO:00224143720.107
lipid metabolic processGO:00066292830.106
positive regulation of extracellular matrix constituent secretionGO:000333120.104
response to inorganic substanceGO:00100353770.104
fatty acid metabolic processGO:0006631990.103
organic anion transportGO:00157111320.103
tripeptide transportGO:004293920.102
regulation of phosphate metabolic processGO:00192203490.102
defense responseGO:00069521940.099
response to peptideGO:19016522920.098
response to glucocorticoidGO:00513842230.097
regulation of cell proliferationGO:00421273590.096
cell cell signalingGO:00072673350.096
naphthalene containing compound metabolic processGO:009042020.095
response to external biotic stimulusGO:00432072210.094
response to acid chemicalGO:00011012220.092
cation transportGO:00068123820.091
protein homooligomerizationGO:0051260910.090
response to metal ionGO:00100382530.088
organic substance catabolic processGO:19015753160.087
response to corticosteroidGO:00319602350.087
ribonucleotide metabolic processGO:00092592310.087
response to carbohydrateGO:00097431830.086
coenzyme metabolic processGO:0006732860.086
response to cytokineGO:00340972150.086
cellular amino acid metabolic processGO:00065201070.085
nitrogen compound transportGO:00717052290.084
negative regulation of serine type endopeptidase activityGO:190000410.083
cellular response to organic cyclic compoundGO:00714072020.080
nucleobase containing small molecule metabolic processGO:00550863160.078
cofactor metabolic processGO:0051186950.077
divalent inorganic cation homeostasisGO:00725071650.077
response to organophosphorusGO:00466831020.075
cellular component assemblyGO:00226073600.074
vesicle mediated transportGO:00161921810.072
regulation of ion transportGO:00432692450.072
response to nutrientGO:00075842480.071
divalent metal ion transportGO:00708381320.069
regulation of serine type peptidase activityGO:190257110.068
monocarboxylic acid metabolic processGO:00327871520.068
regulation of hormone secretionGO:00468831060.067
cellular response to organonitrogen compoundGO:00714171970.067
agingGO:00075682410.066
cation homeostasisGO:00550801950.065
response to biotic stimulusGO:00096072260.064
cellular response to steroid hormone stimulusGO:0071383930.064
response to toxic substanceGO:00096361330.063
antibiotic transportGO:004289120.062
amine metabolic processGO:0009308380.062
response to molecule of bacterial originGO:00022371940.062
regulation of synaptic transmissionGO:00508041410.062
nucleoside phosphate metabolic processGO:00067532830.061
intracellular signal transductionGO:00355563140.061
regulation of cellular component organizationGO:00511283680.061
response to growth factorGO:00708481890.060
organic hydroxy compound biosynthetic processGO:1901617510.060
cellular response to peptide hormone stimulusGO:00713751200.060
regulation of protein metabolic processGO:00512462890.059
cellular amine metabolic processGO:0044106380.059
ion homeostasisGO:00508012120.059
positive regulation of cellular component movementGO:00512721020.058
cellular response to glucocorticoid stimulusGO:0071385680.058
response to estrogenGO:00436272320.057
cellular modified amino acid metabolic processGO:0006575610.057
carboxylic acid biosynthetic processGO:0046394830.057
organic hydroxy compound metabolic processGO:19016151150.057
organelle organizationGO:00069962660.056
cellular catabolic processGO:00442482950.056
positive regulation of immune system processGO:0002684900.056
response to hexoseGO:00097461440.056
regulation of vesicle mediated transportGO:0060627810.056
cytokine productionGO:0001816610.054
hormone secretionGO:00468791150.053
modified amino acid transportGO:0072337120.053
amide transportGO:00428861050.053
single organism reproductive processGO:00447022970.053
catechol containing compound biosynthetic processGO:000971390.052
vascular process in circulatory systemGO:0003018960.052
macromolecular complex subunit organizationGO:00439333390.052
response to zinc ionGO:0010043390.051
cellular response to hormone stimulusGO:00328702470.050
secretion by cellGO:00329402480.050
regulation of body fluid levelsGO:0050878900.050
cellular component biogenesisGO:00440853680.049
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188510.049
quaternary ammonium group transportGO:001569760.049
cellular response to lipidGO:00713962010.049
cellular component movementGO:00069282480.048
macromolecule localizationGO:00330362520.048
purine nucleotide biosynthetic processGO:0006164830.048
organophosphate biosynthetic processGO:00904071430.048
purine nucleotide metabolic processGO:00061632290.048
sodium independent organic anion transportGO:004325220.048
calcitriol biosynthetic process from calciolGO:003637820.047
regulation of serine type endopeptidase activityGO:190000310.046
organic acid biosynthetic processGO:0016053830.046
regulation of extracellular matrix constituent secretionGO:000333020.045
response to campGO:0051591910.045
positive regulation of secretion by cellGO:19035321280.045
response to purine containing compoundGO:00140741260.045
regulation of homeostatic processGO:00328441010.044
amino acid transportGO:0006865700.044
blood circulationGO:00080151830.044
response to mercury ionGO:0046689150.043
development of primary sexual characteristicsGO:00451371070.043
second messenger mediated signalingGO:0019932510.043
lipid transportGO:0006869610.043
organic acid transportGO:00158491160.042
positive regulation of cell activationGO:0050867340.042
organic cation transportGO:0015695110.042
negative regulation of natural killer cell mediated cytotoxicityGO:004595340.041
cellular response to fluid shear stressGO:007149840.041
purine ribonucleotide metabolic processGO:00091502270.041
defense response to other organismGO:0098542170.041
response to glucoseGO:00097491360.040
establishment of protein localizationGO:00451841410.040
synaptic transmissionGO:00072682350.040
cellular response to insulin stimulusGO:0032869810.040
metal ion homeostasisGO:00550651860.040
response to alkaloidGO:00432791320.040
nitrogen cycle metabolic processGO:007194150.039
response to oxygen levelsGO:00704822650.039
divalent inorganic cation transportGO:00725111340.038
regulation of secretionGO:00510462240.038
nucleotide metabolic processGO:00091172790.038
regulation of adenylate cyclase activityGO:0045761180.038
cellular response to growth factor stimulusGO:00713631620.037
cellular chemical homeostasisGO:00550822470.037
urea metabolic processGO:001962750.037
regulation of cell motilityGO:20001451310.037
peptide transportGO:0015833970.037
positive regulation of erk1 and erk2 cascadeGO:0070374290.037
regulation of cell migrationGO:00303341280.037
regulation of response to stressGO:00801341260.036
response to ketoneGO:19016541820.036
single organism catabolic processGO:00447122830.036
cellular metal ion homeostasisGO:00068751720.036
negative regulation of calcium ion importGO:009028120.036
response to fatty acidGO:0070542650.036
g protein coupled receptor signaling pathwayGO:00071862420.036
positive regulation of secretionGO:00510471400.035
pyridine containing compound metabolic processGO:0072524320.035
regulation of multicellular organismal developmentGO:20000263760.035
multi organism reproductive processGO:00447032620.035
urogenital system developmentGO:0001655780.035
negative regulation of natural killer cell mediated immunityGO:000271640.035
response to ethanolGO:00454711620.035
carbohydrate derivative metabolic processGO:19011353460.035
cellular carbohydrate metabolic processGO:0044262720.035
choline transportGO:001587140.035
cytoskeleton organizationGO:00070101110.035
negative regulation of innate immune responseGO:004582440.034
protein localizationGO:00081041910.034
regulation of epithelial cell proliferationGO:0050678490.034
locomotionGO:00400112370.034
regulation of anion transportGO:0044070430.034
protein oligomerizationGO:00512591910.034
positive regulation of biosynthetic processGO:00098913190.034
response to ddtGO:004668010.033
regulation of phosphorus metabolic processGO:00511743490.033
regulation of anatomical structure sizeGO:00900661350.033
anion transmembrane transportGO:0098656770.032
positive regulation of synaptic transmissionGO:0050806620.032
hormone mediated signaling pathwayGO:0009755230.032
positive regulation of extracellular matrix organizationGO:190305540.032
neurotransmitter transportGO:0006836420.032
positive regulation of leukocyte activationGO:0002696300.032
developmental process involved in reproductionGO:00030061590.032
response to monosaccharideGO:00342841590.032
protein complex biogenesisGO:00702712630.031
regulation of apoptotic processGO:00429813350.031
peristalsisGO:003043220.031
tissue remodelingGO:0048771400.031
aromatic compound catabolic processGO:00194391680.031
alpha amino acid biosynthetic processGO:1901607230.031
regulation of locomotionGO:00400121480.031
reproductionGO:00000032450.031
regulation of carbohydrate metabolic processGO:0006109410.031
tonic smooth muscle contractionGO:001482040.031
organonitrogen compound catabolic processGO:19015651790.030
cellular sodium ion homeostasisGO:000688340.030
cellular response to peptideGO:19016531330.030
calcium ion transportGO:00068161310.030
nicotinamide nucleotide metabolic processGO:0046496280.030
carboxylic acid catabolic processGO:0046395490.030
protein transportGO:00150311320.030
cellular homeostasisGO:00197252520.030
organic hydroxy compound transportGO:0015850770.030
cation transmembrane transportGO:00986552630.030
response to woundingGO:00096112540.029
reactive oxygen species metabolic processGO:0072593370.029
immune system processGO:00023762040.029
positive regulation of hormone secretionGO:0046887650.029
fatty acid derivative metabolic processGO:1901568380.029
peptide hormone secretionGO:0030072840.029
rhythmic processGO:00485111560.029
positive regulation of cell proliferationGO:00082842490.028
purine ribonucleotide biosynthetic processGO:0009152810.028
response to amino acidGO:0043200750.028
regulation of anatomical structure morphogenesisGO:00226031410.028
angiogenesisGO:0001525530.028
developmental growthGO:00485891000.028
dicarboxylic acid transportGO:0006835340.027
multicellular organismal reproductive processGO:00486092330.027
response to oxidative stressGO:00069791860.027
positive regulation of phosphorylationGO:00423271770.027
cellular amino acid biosynthetic processGO:0008652320.027
sex differentiationGO:00075481130.027
organic cyclic compound catabolic processGO:19013611750.027
positive regulation of cell migrationGO:0030335960.027
positive regulation of locomotionGO:00400171020.027
neutral lipid metabolic processGO:0006638210.027
ribose phosphate metabolic processGO:00196932350.026
circulatory system processGO:00030131830.026
response to estradiolGO:00323551640.026
positive regulation of cellular component organizationGO:00511302000.026
regulation of catalytic activityGO:00507903040.026
positive regulation of cell motilityGO:2000147970.026
artery smooth muscle contractionGO:001482440.026
glutamate secretionGO:0014047190.026
signal transduction by phosphorylationGO:00230141440.026
signal releaseGO:00230611450.026
regulation of programmed cell deathGO:00430673410.025
positive regulation of organic acid transportGO:0032892220.025
cellular response to oxygen containing compoundGO:19017013860.025
alcohol biosynthetic processGO:0046165380.025
positive regulation of phosphorus metabolic processGO:00105622620.025
cellular nitrogen compound catabolic processGO:00442701630.025
development of primary female sexual characteristicsGO:0046545560.025
regulation of blood vessel sizeGO:0050880890.025
response to lipopolysaccharideGO:00324961910.025
regulation of exocytosisGO:0017157370.025
regulation of phosphorylationGO:00423252480.025
learning or memoryGO:0007611900.024
negative regulation of epithelial cell proliferationGO:0050680160.024
liver developmentGO:0001889900.024
dna metabolic processGO:0006259960.024
programmed cell deathGO:00125013920.024
regulation of tolerance induction dependent upon immune responseGO:000265210.024
regulation of cellular amine metabolic processGO:003323880.024
cellular ketone metabolic processGO:0042180510.024
positive regulation of cell communicationGO:00106472710.024
positive regulation of nervous system developmentGO:00519621780.024
cellular response to interleukin 1GO:0071347370.024
response to bacteriumGO:00096172000.023
acid secretionGO:0046717480.023
gland developmentGO:00487321550.023
female pregnancyGO:00075651220.023
circadian rhythmGO:0007623880.023
positive regulation of cellular component biogenesisGO:0044089550.023
sequestering of calcium ionGO:005120880.023
intracellular transportGO:00469071850.023
reproductive structure developmentGO:00486081280.023
cellular response to glucagon stimulusGO:007137770.023
cellular response to corticosteroid stimulusGO:0071384690.023
single organism intracellular transportGO:19025821660.022
regulation of defecationGO:200029210.022
positive regulation of nitrogen compound metabolic processGO:00511733340.022
cognitionGO:0050890920.022
cyclic nucleotide metabolic processGO:0009187800.022
regulation of angiogenesisGO:0045765390.022
small molecule catabolic processGO:0044282590.022
purine ribonucleoside metabolic processGO:00461281680.022
response to decreased oxygen levelsGO:00362932370.022
renin angiotensin regulation of aldosterone productionGO:000201830.022
phospholipid metabolic processGO:0006644610.022
positive regulation of blood circulationGO:1903524650.021
regulation of ion transmembrane transportGO:00347651210.021
sequestering of metal ionGO:005123890.021
angiotensin mediated drinking behaviorGO:000305120.021
calcium ion transmembrane transportGO:0070588700.021
multicellular organism reproductionGO:00325042330.021
regulation of nervous system developmentGO:00519602640.021
response to reactive oxygen speciesGO:00003021200.021
positive regulation of mapk cascadeGO:0043410920.021
kidney developmentGO:0001822670.021
alpha amino acid catabolic processGO:1901606200.021
regulation of kinase activityGO:00435491170.021
single organism carbohydrate metabolic processGO:00447231180.021
positive regulation of phosphate metabolic processGO:00459372620.020
cellular cation homeostasisGO:00300031800.020
lipid localizationGO:0010876620.020
regulation of cellular amino acid metabolic processGO:000652120.020
purine containing compound biosynthetic processGO:0072522850.020
regulation of cellular ketone metabolic processGO:0010565270.020
t cell tolerance inductionGO:000251730.020
bile acid and bile salt transportGO:0015721120.020
alkaloid metabolic processGO:000982030.020
defecationGO:003042110.020
regulation of intracellular signal transductionGO:19025312180.020
insecticide metabolic processGO:001714340.019
icosanoid metabolic processGO:0006690380.019
positive regulation of leukocyte degranulationGO:004330240.019
regulation of immune responseGO:0050776550.019
gonad developmentGO:00084061040.019
learningGO:0007612330.019
positive regulation of signalingGO:00230562700.019
regulation of immune system processGO:00026821230.019
regulation of ion homeostasisGO:2000021630.019
cellular response to hexose stimulusGO:0071331650.019
regulation of calcium ion transportGO:0051924770.019
phenol containing compound metabolic processGO:0018958300.019
positive regulation of catalytic activityGO:00430851840.019
negative regulation of transportGO:00510511360.019
positive regulation of serotonin secretionGO:001406410.019
heterocycle catabolic processGO:00467001670.019
positive regulation of molecular functionGO:00440932300.019
cell activationGO:0001775970.018
indolalkylamine metabolic processGO:000658650.018
regulation of immune response to tumor cellGO:000283730.018
positive regulation of adenylate cyclase activityGO:0045762120.018
regulation of cellular component movementGO:00512701500.018
ribonucleoside triphosphate catabolic processGO:00092031220.018
regulation of cell differentiationGO:00455953200.018
olfactory learningGO:000835510.018
growthGO:00400071650.018
negative regulation of long term synaptic potentiationGO:190027210.018
response to radiationGO:00093141370.018
long chain fatty acid metabolic processGO:0001676320.017
negative regulation of cell deathGO:00605482290.017
cytoplasmic transportGO:00164821150.017
cellular response to stressGO:00335542690.017
regulation of cell developmentGO:00602842630.017
brain renin angiotensin systemGO:000203530.017
serine family amino acid metabolic processGO:0009069120.017
reproductive system developmentGO:00614581280.017
response to cesium ionGO:001016420.017
calcium ion importGO:0070509220.017
response to chromateGO:004668730.017
glucose homeostasisGO:0042593750.017
maintenance of locationGO:0051235170.017
purine nucleoside triphosphate catabolic processGO:00091461220.017
striated muscle tissue developmentGO:0014706580.017
regulation of cytoskeleton organizationGO:0051493490.017
acylglycerol metabolic processGO:0006639210.016
organic acid catabolic processGO:0016054490.016
glycosyl compound metabolic processGO:19016571820.016
purine ribonucleoside monophosphate metabolic processGO:0009167840.016
blood vessel developmentGO:0001568690.016
negative regulation of cell proliferationGO:00082851190.016
linoleic acid metabolic processGO:004365140.016
proteolysisGO:00065081750.016
neurological system process involved in regulation of systemic arterial blood pressureGO:000197630.016
multicellular organism growthGO:003526410.016
regulation of reactive oxygen species metabolic processGO:2000377260.016
regulation of cell activationGO:0050865500.016
gastric inhibitory peptide signaling pathwayGO:003819210.016
regulated secretory pathwayGO:0045055170.016
glucagon secretionGO:007009150.016
erk1 and erk2 cascadeGO:0070371480.016
regulation of leukocyte activationGO:0002694450.016
arachidonic acid metabolic processGO:0019369200.016
immune response to tumor cellGO:000241830.016
pyridine nucleotide metabolic processGO:0019362280.016
response to tumor cellGO:000234740.016
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187550.016
response to triglycerideGO:003401430.016
nucleoside phosphate biosynthetic processGO:19012931020.016
circulatory system developmentGO:00723591340.016
cellular macromolecule localizationGO:00707271220.016
positive regulation of cellular amino acid metabolic processGO:004576410.015
positive regulation of apoptotic processGO:00430651540.015
protein secretionGO:0009306340.015
positive regulation of cell deathGO:00109421840.015
positive regulation of cell differentiationGO:00455972170.015
regulation of cyclic nucleotide metabolic processGO:0030799510.015
developmental inductionGO:003112820.015
response to insulinGO:00328681330.015
response to dexamethasoneGO:0071548490.015
cellular lipid catabolic processGO:0044242370.015
oxidoreduction coenzyme metabolic processGO:0006733310.015
triglyceride metabolic processGO:0006641210.015
defense response to gram negative bacteriumGO:005082930.015
regulation of erk1 and erk2 cascadeGO:0070372410.015
apoptotic processGO:00069153810.015
cellular response to external stimulusGO:00714961180.015
cellular response to estradiol stimulusGO:0071392160.015
nucleotide biosynthetic processGO:0009165980.015
smooth muscle contractionGO:0006939370.015
positive regulation of cyclic nucleotide metabolic processGO:0030801370.015
regulation of nucleotide metabolic processGO:00061401170.015
stress activated mapk cascadeGO:0051403350.014
renal system developmentGO:0072001670.014
ribonucleotide biosynthetic processGO:0009260850.014
amino acid betaine transportGO:001583810.014
phasic smooth muscle contractionGO:001482130.014
response to mechanical stimulusGO:00096121340.014
peptide secretionGO:0002790860.014
cell activation involved in immune responseGO:0002263160.014
regulation of organic acid transportGO:0032890350.014
ethanolamine containing compound metabolic processGO:0042439140.014
nucleoside phosphate catabolic processGO:19012921400.014
positive regulation of calcium ion transportGO:0051928360.014
pyrimidine nucleobase catabolic processGO:000620830.014
response to muscle activity involved in regulation of muscle adaptationGO:001487320.014
single organism behaviorGO:00447081300.014
response to ammonium ionGO:0060359710.014
negative regulation of multicellular organismal processGO:00512412030.014
spermatogenesisGO:0007283990.014
cellular response to lipopolysaccharideGO:0071222550.014
regulation of cellular carbohydrate metabolic processGO:0010675390.014
positive regulation of developmental processGO:00510942830.014
cellular response to oxidative stressGO:0034599760.014
protein phosphorylationGO:00064683450.014
carbohydrate metabolic processGO:00059751300.014
chronic inflammatory response to non antigenic stimulusGO:000254510.014
lipid biosynthetic processGO:00086101280.014
ribonucleoside triphosphate metabolic processGO:00091991410.014
response to methanolGO:003398610.014
synaptic growth at neuromuscular junctionGO:005112410.014
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressureGO:000199910.014
positive regulation of nucleotide metabolic processGO:0045981910.014
blood vessel morphogenesisGO:0048514580.014
polyol metabolic processGO:0019751200.014
positive regulation of programmed cell deathGO:00430681570.014
negative regulation of natural killer cell mediated immune response to tumor cellGO:000285610.013
beta alanine metabolic processGO:001948230.013
thymine catabolic processGO:000621020.013
memoryGO:0007613540.013
gamete generationGO:00072761240.013
dicarboxylic acid metabolic processGO:0043648420.013
regulation of protein modification processGO:00313991940.013
cell migrationGO:00164771970.013
exogenous drug catabolic processGO:004273810.013
regulation of establishment of protein localizationGO:0070201690.013
actin filament bundle organizationGO:0061572190.013
nuclear transportGO:0051169490.013
positive regulation of protein metabolic processGO:00512471780.013
single organism cellular localizationGO:19025801020.013
positive regulation of blood pressureGO:0045777310.013
positive regulation of response to stimulusGO:00485842850.013
regulation of synaptic plasticityGO:0048167700.013
leukocyte activationGO:0045321760.013
retinal metabolic processGO:004257430.013
carbohydrate phosphorylationGO:0046835160.013
regulation of peptide hormone secretionGO:0090276800.013
toxin transportGO:190199830.013
multicellular organismal signalingGO:0035637440.013

Kynu disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.127
vascular diseaseDOID:17800.127
cardiovascular system diseaseDOID:128700.127
musculoskeletal system diseaseDOID:1700.025
disease of cellular proliferationDOID:1456600.015
nervous system diseaseDOID:86300.013