Rattus norvegicus

0 known processes

Dmrta1

DMRT-like family A1

Dmrta1 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to nutrient levelsGO:00316673700.281
transmembrane transportGO:00550854120.276
regulation of cellular localizationGO:00603412630.221
cell cell signalingGO:00072673350.203
response to glucocorticoidGO:00513842230.187
regulation of system processGO:00440572080.185
response to estrogenGO:00436272320.179
organelle organizationGO:00069962660.178
nitrogen compound transportGO:00717052290.173
cellular response to endogenous stimulusGO:00714953770.172
response to extracellular stimulusGO:00099913800.158
response to decreased oxygen levelsGO:00362932370.157
cellular component assemblyGO:00226073600.147
organonitrogen compound biosynthetic processGO:19015661670.147
response to nutrientGO:00075842480.146
regulation of metal ion transportGO:00109591180.140
hormone transportGO:00099141210.135
neurological system process involved in regulation of systemic arterial blood pressureGO:000197630.134
cellular response to stressGO:00335542690.131
secretionGO:00469033070.126
regulation of blood circulationGO:19035221100.126
cellular ion homeostasisGO:00068731840.125
negative regulation of cell communicationGO:00106481580.123
positive regulation of multicellular organismal processGO:00512403870.117
negative regulation of metabolic processGO:00098923310.116
secretion by cellGO:00329402480.114
response to inorganic substanceGO:00100353770.114
catabolic processGO:00090563510.113
regulation of cellular component movementGO:00512701500.112
protein complex subunit organizationGO:00718223020.111
response to corticosteroidGO:00319602350.108
cellular component biogenesisGO:00440853680.104
heart processGO:0003015570.103
rna metabolic processGO:00160704060.100
homeostatic processGO:00425923310.096
positive regulation of nitrogen compound metabolic processGO:00511733340.095
central nervous system developmentGO:00074173110.091
regenerationGO:00310991630.090
regulation of blood pressureGO:0008217830.089
single organism biosynthetic processGO:00447113420.089
single organism carbohydrate metabolic processGO:00447231180.086
nucleobase containing small molecule metabolic processGO:00550863160.086
regulation of ion transportGO:00432692450.084
regulation of cell proliferationGO:00421273590.083
hormone secretionGO:00468791150.083
stress activated protein kinase signaling cascadeGO:0031098370.083
cation homeostasisGO:00550801950.082
carboxylic acid metabolic processGO:00197522890.077
cellular response to organonitrogen compoundGO:00714171970.077
organic hydroxy compound transportGO:0015850770.076
anion transportGO:00068201780.076
circulatory system processGO:00030131830.075
cellular catabolic processGO:00442482950.074
g protein coupled receptor signaling pathwayGO:00071862420.074
head developmentGO:00603222470.072
cellular response to nitrogen compoundGO:19016992100.071
nucleotide biosynthetic processGO:0009165980.071
response to estradiolGO:00323551640.071
response to mineralocorticoidGO:0051385490.067
positive regulation of molecular functionGO:00440932300.067
muscle contractionGO:0006936880.066
negative regulation of cellular metabolic processGO:00313242810.066
regulation of peptide secretionGO:0002791820.065
response to peptideGO:19016522920.065
single organism organelle organizationGO:19025891800.064
smooth muscle contractionGO:0006939370.064
regulation of secretionGO:00510462240.059
cellular amino acid metabolic processGO:00065201070.059
regulation of hormone secretionGO:00468831060.059
regulation of hormone levelsGO:00108171870.058
peptide transportGO:0015833970.057
blood circulationGO:00080151830.057
macromolecular complex assemblyGO:00650032730.057
amine metabolic processGO:0009308380.057
agingGO:00075682410.056
peptide secretionGO:0002790860.055
macromolecular complex subunit organizationGO:00439333390.055
multi organism reproductive processGO:00447032620.054
cellular ketone metabolic processGO:0042180510.054
reproductive processGO:00224143720.054
positive regulation of peptide secretionGO:0002793520.054
defense responseGO:00069521940.054
vasodilationGO:0042311440.053
cellular response to hormone stimulusGO:00328702470.053
cellular response to interleukin 1GO:0071347370.053
positive regulation of developmental processGO:00510942830.052
cellular response to steroid hormone stimulusGO:0071383930.052
regulation of secretion by cellGO:19035302080.051
programmed cell deathGO:00125013920.050
single organism catabolic processGO:00447122830.049
forebrain developmentGO:0030900980.049
positive regulation of long term synaptic potentiationGO:190027340.049
regulation of muscle system processGO:0090257790.049
response to ketoneGO:19016541820.049
inorganic ion transmembrane transportGO:00986602290.049
positive regulation of biosynthetic processGO:00098913190.048
brain renin angiotensin systemGO:000203530.048
response to acid chemicalGO:00011012220.048
response to peptide hormoneGO:00434342780.048
neurological system processGO:00508772190.047
multicellular organismal reproductive processGO:00486092330.047
regulation of anatomical structure sizeGO:00900661350.046
proteolysisGO:00065081750.046
positive regulation of cell proliferationGO:00082842490.046
regulation of cellular amine metabolic processGO:003323880.046
amide transportGO:00428861050.045
regulation of peptide hormone secretionGO:0090276800.045
muscle system processGO:00030121150.045
positive regulation of response to stimulusGO:00485842850.044
response to hexoseGO:00097461440.044
carbohydrate derivative metabolic processGO:19011353460.044
response to starvationGO:0042594590.044
sensory perceptionGO:00076001010.044
nucleic acid templated transcriptionGO:00976593790.043
intracellular signal transductionGO:00355563140.043
Rat
ion transmembrane transportGO:00342203650.043
cellular response to peptide hormone stimulusGO:00713751200.043
regulation of heart contractionGO:0008016480.042
positive regulation of cellular component organizationGO:00511302000.042
organic acid metabolic processGO:00060822920.042
sensory organ developmentGO:0007423740.042
positive regulation of secretion by cellGO:19035321280.041
regulation of response to stressGO:00801341260.041
macromolecule localizationGO:00330362520.041
regulation of excretionGO:0044062210.041
negative regulation of response to stimulusGO:00485851550.041
cardiovascular system developmentGO:00723581340.041
regulation of neurological system processGO:0031644430.040
cellular homeostasisGO:00197252520.040
metal ion transportGO:00300012890.040
cellular response to cytokine stimulusGO:00713451270.040
regulation of kinase activityGO:00435491170.039
protein transportGO:00150311320.038
organophosphate metabolic processGO:00196373700.038
protein complex assemblyGO:00064612630.038
response to transition metal nanoparticleGO:19902671220.038
negative regulation of signalingGO:00230571570.037
cellular response to external stimulusGO:00714961180.037
regulation of catalytic activityGO:00507903040.037
cellular cation homeostasisGO:00300031800.036
peptide hormone secretionGO:0030072840.036
ribonucleotide metabolic processGO:00092592310.036
regulation of cellular component organizationGO:00511283680.036
regulation of blood vessel sizeGO:0050880890.036
nucleoside phosphate metabolic processGO:00067532830.036
divalent inorganic cation transportGO:00725111340.036
divalent inorganic cation homeostasisGO:00725071650.035
cell communication involved in cardiac conductionGO:008606520.035
positive regulation of synaptic transmissionGO:0050806620.034
positive regulation of cell differentiationGO:00455972170.034
regulation of cellular amino acid metabolic processGO:000652120.034
carboxylic acid transportGO:00469421150.034
endocrine processGO:0050886320.034
signal releaseGO:00230611450.034
purine nucleotide metabolic processGO:00061632290.034
purine containing compound metabolic processGO:00725212530.033
oxoacid metabolic processGO:00434362900.033
cytosolic calcium ion homeostasisGO:00514801400.033
cellular response to organic cyclic compoundGO:00714072020.033
cellular response to alcoholGO:0097306870.033
telencephalon developmentGO:0021537620.033
regulation of calcium ion transportGO:0051924770.033
regulation of intracellular signal transductionGO:19025312180.032
protein complex biogenesisGO:00702712630.032
chemical homeostasisGO:00488782920.032
response to external biotic stimulusGO:00432072210.032
protein phosphorylationGO:00064683450.032
cellular metal ion homeostasisGO:00068751720.032
negative regulation of signal transductionGO:0009968830.031
small gtpase mediated signal transductionGO:0007264360.031
brain developmentGO:00074202470.031
regulation of locomotionGO:00400121480.031
regulation of molecular functionGO:00650093980.031
regulation of systemic arterial blood pressureGO:0003073300.031
nucleoside phosphate biosynthetic processGO:19012931020.031
cation transportGO:00068123820.031
insulin secretionGO:0030073690.031
organ regenerationGO:00311001010.030
ribose phosphate metabolic processGO:00196932350.030
cellular response to metal ionGO:0071248550.030
regulation of homeostatic processGO:00328441010.030
regulation of multicellular organismal developmentGO:20000263760.030
regulation of anatomical structure morphogenesisGO:00226031410.030
locomotionGO:00400112370.029
synapse organizationGO:0050808460.029
ribonucleoside triphosphate metabolic processGO:00091991410.029
neuropeptide signaling pathwayGO:0007218290.029
cellular amine metabolic processGO:0044106380.029
regulation of body fluid levelsGO:0050878900.029
response to vitaminGO:00332731310.029
cellular response to oxygen containing compoundGO:19017013860.029
cellular response to extracellular stimulusGO:0031668730.029
ion homeostasisGO:00508012120.028
response to cytokineGO:00340972150.028
regulation of organelle organizationGO:0033043800.028
response to corticosteroneGO:0051412400.028
organonitrogen compound catabolic processGO:19015651790.028
regulation of cellular component biogenesisGO:0044087860.027
response to mechanical stimulusGO:00096121340.027
purine nucleotide biosynthetic processGO:0006164830.027
positive regulation of cytosolic calcium ion concentrationGO:00072041220.027
positive regulation of peptide hormone secretionGO:0090277500.027
response to interleukin 1GO:0070555550.027
positive regulation of blood pressure by epinephrine norepinephrineGO:000332120.027
multicellular organismal signalingGO:0035637440.027
tissue developmentGO:00098882520.026
negative regulation of secretionGO:0051048820.026
cell projection organizationGO:00300303020.026
negative regulation of macromolecule metabolic processGO:00106052600.026
small molecule biosynthetic processGO:00442831240.026
regulation of rna metabolic processGO:00512523910.026
stress activated mapk cascadeGO:0051403350.026
behaviorGO:00076102050.026
positive regulation of cellular biosynthetic processGO:00313282950.026
regulation of protein modification processGO:00313991940.026
divalent metal ion transportGO:00708381320.026
positive regulation of hormone secretionGO:0046887650.025
regulation of cellular ketone metabolic processGO:0010565270.025
positive regulation of signalingGO:00230562700.025
regulation of response to external stimulusGO:00321011060.025
response to carbohydrateGO:00097431830.025
actin cytoskeleton organizationGO:0030036730.025
response to ethanolGO:00454711620.024
negative regulation of peptide hormone secretionGO:0090278300.024
cellular protein localizationGO:00346131220.024
positive regulation of blood circulationGO:1903524650.024
negative regulation of hormone secretionGO:0046888460.023
establishment of protein localizationGO:00451841410.023
response to monosaccharideGO:00342841590.023
positive regulation of ion transportGO:0043270940.023
regulation of cell motilityGO:20001451310.023
positive regulation of phosphate metabolic processGO:00459372620.023
anatomical structure morphogenesisGO:00096532980.023
positive regulation of heart contractionGO:0045823150.023
protein localizationGO:00081041910.023
positive regulation of cellular amino acid metabolic processGO:004576410.022
response to oxygen levelsGO:00704822650.022
positive regulation of macromolecule biosynthetic processGO:00105572470.022
sexual reproductionGO:00199531480.022
negative regulation of gene expressionGO:00106291990.022
neuron developmentGO:00486662860.022
organic substance catabolic processGO:19015753160.022
negative regulation of cellular protein metabolic processGO:00322691060.022
kidney developmentGO:0001822670.022
positive regulation of cytoskeleton organizationGO:0051495260.022
cellular response to corticosteroid stimulusGO:0071384690.022
positive regulation of protein serine threonine kinase activityGO:0071902520.022
purine ribonucleotide metabolic processGO:00091502270.022
actin filament based processGO:0030029860.022
regulation of hydrolase activityGO:00513361430.022
calcium ion homeostasisGO:00550741620.021
cyclic nucleotide metabolic processGO:0009187800.021
response to molecule of bacterial originGO:00022371940.021
negative regulation of cell proliferationGO:00082851190.021
response to metal ionGO:00100382530.021
multicellular organism reproductionGO:00325042330.021
positive regulation of nucleobase containing compound metabolic processGO:00459353190.021
regulation of cellular response to stressGO:0080135490.021
cellular response to lipidGO:00713962010.021
single organism reproductive processGO:00447022970.021
heart developmentGO:0007507720.020
ribonucleotide biosynthetic processGO:0009260850.020
glycosyl compound metabolic processGO:19016571820.020
membrane repolarizationGO:008600910.020
vascular process in circulatory systemGO:0003018960.020
heart contractionGO:0060047570.020
regulation of neuron deathGO:19012141150.020
regulation of insulin secretionGO:0050796650.020
transmission of nerve impulseGO:0019226420.020
response to osmotic stressGO:0006970420.020
cellular nitrogen compound catabolic processGO:00442701630.020
purine containing compound biosynthetic processGO:0072522850.020
excretionGO:0007588240.020
multi multicellular organism processGO:00447061380.020
cyclic purine nucleotide metabolic processGO:0052652620.020
purine nucleoside triphosphate metabolic processGO:00091441410.020
positive regulation of protein phosphorylationGO:00019341350.020
positive regulation of rna metabolic processGO:00512542030.019
regulation of adenylate cyclase activityGO:0045761180.019
intracellular transportGO:00469071850.019
transcription dna templatedGO:00063513770.019
regulation of lyase activityGO:0051339220.019
developmental process involved in reproductionGO:00030061590.019
positive regulation of cellular protein metabolic processGO:00322701670.019
urogenital system developmentGO:0001655780.019
nucleotide metabolic processGO:00091172790.019
regulation of cytoskeleton organizationGO:0051493490.019
oxidation reduction processGO:00551143040.019
signal transduction by phosphorylationGO:00230141440.019
heart morphogenesisGO:000300730.019
cardiac conductionGO:006133720.019
organophosphate biosynthetic processGO:00904071430.019
regulation of transferase activityGO:00513381230.019
carbohydrate derivative biosynthetic processGO:19011371240.019
circulatory system developmentGO:00723591340.019
cardiac chamber developmentGO:000320510.019
positive regulation of transferase activityGO:0051347810.019
positive regulation of nucleic acid templated transcriptionGO:19035081970.018
positive regulation of protein kinase activityGO:0045860730.018
chemosensory behaviorGO:000763520.018
androgen biosynthetic processGO:0006702100.018
negative regulation of apoptotic processGO:00430661810.018
response to progesteroneGO:0032570480.018
peptidyl amino acid modificationGO:00181931260.018
negative regulation of protein metabolic processGO:00512481140.018
response to glucoseGO:00097491360.018
metal ion homeostasisGO:00550651860.018
olfactory learningGO:000835510.018
embryonic appendage morphogenesisGO:003511340.018
regulation of membrane potentialGO:00423911100.018
amine transportGO:0015837570.018
negative regulation of transportGO:00510511360.018
purine ribonucleoside triphosphate metabolic processGO:00092051400.018
positive regulation of cellular amine metabolic processGO:003324030.018
regulation of neurotransmitter uptakeGO:005158010.018
organic anion transportGO:00157111320.017
inflammatory responseGO:00069541500.017
response to activityGO:0014823730.017
calcium ion transportGO:00068161310.017
regulation of peptide transportGO:0090087870.017
regulation of phosphorylationGO:00423252480.017
micturitionGO:006007340.017
inorganic cation transmembrane transportGO:00986622020.017
response to oxidative stressGO:00069791860.017
response to other organismGO:00517072200.017
organic acid biosynthetic processGO:0016053830.017
cellular divalent inorganic cation homeostasisGO:00725031620.017
regulation of phosphate metabolic processGO:00192203490.017
female pregnancyGO:00075651220.017
regulation of signal transductionGO:00099663180.017
regulation of camp biosynthetic processGO:0030817380.017
negative regulation of catalytic activityGO:00430861030.017
ribose phosphate biosynthetic processGO:0046390870.017
regulation of apoptotic processGO:00429813350.017
cellular calcium ion homeostasisGO:00068741600.017
protein oligomerizationGO:00512591910.017
mapk cascadeGO:00001651400.017
cellular response to nutrient levelsGO:0031669600.017
purine nucleoside triphosphate catabolic processGO:00091461220.017
positive regulation of gene expressionGO:00106282440.017
apoptotic processGO:00069153810.017
positive regulation of catalytic activityGO:00430851840.016
adenylate cyclase inhibiting serotonin receptor signaling pathwayGO:000719810.016
cellular macromolecule localizationGO:00707271220.016
monovalent inorganic cation transportGO:00156721720.016
rna biosynthetic processGO:00327743800.016
cell migrationGO:00164771970.016
urinary tract smooth muscle contractionGO:001484840.016
peptide biosynthetic processGO:004304330.016
cytoskeleton organizationGO:00070101110.016
regulation of nucleotide metabolic processGO:00061401170.016
potassium ion transportGO:0006813970.016
regulation of ion homeostasisGO:2000021630.016
regulation of amine transportGO:0051952540.016
camera type eye developmentGO:0043010480.016
response to alkaloidGO:00432791320.016
response to hypoxiaGO:00016662310.016
urinary bladder smooth muscle contractionGO:001483240.016
lipid metabolic processGO:00066292830.016
regulation of cellular protein metabolic processGO:00322682670.016
response to zinc ionGO:0010043390.016
reproductionGO:00000032450.016
response to vitamin aGO:0033189360.016
negative regulation of protein maturationGO:1903318470.016
epithelial cell proliferationGO:0050673540.016
regulation of mapk cascadeGO:00434081160.015
regulation of transcription dna templatedGO:00063553740.015
positive regulation of nervous system developmentGO:00519621780.015
positive regulation of protein modification processGO:00314011420.015
regulation of actin cytoskeleton organizationGO:0032956300.015
regulation of sensory perception of painGO:0051930290.015
developmental growthGO:00485891000.015
regulation of cyclase activityGO:0031279210.015
regulation of cyclic nucleotide metabolic processGO:0030799510.015
appendage morphogenesisGO:003510740.015
positive regulation of transportGO:00510502450.015
synapse assemblyGO:0007416290.015
positive regulation of secretionGO:00510471400.015
regulation of tube sizeGO:0035150890.015
response to temperature stimulusGO:0009266940.015
positive regulation of the force of heart contraction by epinephrine norepinephrineGO:000199720.015
regulation of cell projection organizationGO:00313441750.015
response to amineGO:0014075460.015
positive regulation of rna biosynthetic processGO:19026801970.015
positive regulation of cell communicationGO:00106472710.014
alpha amino acid metabolic processGO:1901605710.014
regulation of epithelial cell proliferationGO:0050678490.014
regulation of purine nucleotide biosynthetic processGO:1900371460.014
reproductive system developmentGO:00614581280.014
reactive oxygen species biosynthetic processGO:190340980.014
regulation of purine nucleotide metabolic processGO:19005421150.014
immune responseGO:00069551040.014
regulation of transmembrane transportGO:00347621220.014
c21 steroid hormone metabolic processGO:0008207140.014
cellular chemical homeostasisGO:00550822470.014
comma shaped body morphogenesisGO:007204920.014
cofactor metabolic processGO:0051186950.014
purine ribonucleoside metabolic processGO:00461281680.014
ribonucleoside triphosphate catabolic processGO:00092031220.014
carbohydrate derivative catabolic processGO:19011361470.014
purine ribonucleotide biosynthetic processGO:0009152810.014
negative regulation of secretion by cellGO:1903531720.014
negative regulation of intracellular signal transductionGO:1902532380.014
liver developmentGO:0001889900.014
regulation of systemic arterial blood pressure by norepinephrine epinephrineGO:000199320.014
single organism behaviorGO:00447081300.014
cellular response to reactive oxygen speciesGO:0034614550.014
nucleobase containing compound catabolic processGO:00346551520.014
negative regulation of phosphorus metabolic processGO:0010563800.014
camp biosynthetic processGO:0006171470.014
response to reactive oxygen speciesGO:00003021200.014
vasculature developmentGO:0001944700.014
neuron neuron synaptic transmissionGO:0007270600.014
muscle cell proliferationGO:0033002840.013
regulation of nervous system developmentGO:00519602640.013
regulation of phosphorus metabolic processGO:00511743490.013
cation transmembrane transportGO:00986552630.013
ribonucleoside catabolic processGO:00424541260.013
monocarboxylic acid transportGO:0015718520.013
muscle organ morphogenesisGO:004864410.013
regulation of cyclic nucleotide biosynthetic processGO:0030802450.013
purine nucleoside metabolic processGO:00422781690.013
intracellular receptor signaling pathwayGO:0030522350.013
cell growthGO:00160491040.013
regulation of nucleic acid templated transcriptionGO:19035063800.013
generation of precursor metabolites and energyGO:0006091620.013
nucleoside triphosphate metabolic processGO:00091411440.013
renal system processGO:0003014400.013
necroptotic processGO:007026620.013
nucleoside catabolic processGO:00091641260.013
negative regulation of nitrogen compound metabolic processGO:00511721610.013
limbic system developmentGO:0021761380.013
regulation of rna biosynthetic processGO:20011413810.013
renal system process involved in regulation of systemic arterial blood pressureGO:0003071140.013
regulation of lipid metabolic processGO:0019216680.013
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressureGO:000199910.013
cellular response to glucocorticoid stimulusGO:0071385680.013
multicellular organism growthGO:003526410.013
cellular component movementGO:00069282480.013
jnk cascadeGO:0007254280.013
regulation of actin filament based processGO:0032970420.012
long term synaptic potentiationGO:0060291210.012
positive regulation of cell developmentGO:00107201760.012
carboxylic acid biosynthetic processGO:0046394830.012
ribonucleoside metabolic processGO:00091191740.012
response to growth factorGO:00708481890.012
regulation of immune system processGO:00026821230.012
regulation of catecholamine secretionGO:0050433320.012
regulation of protein processingGO:0070613500.012
positive regulation of nucleotide metabolic processGO:0045981910.012
regulation of cell migrationGO:00303341280.012
rho protein signal transductionGO:0007266110.012
ras protein signal transductionGO:0007265290.012
protein processingGO:0016485680.012
olfactory behaviorGO:004204820.012
sensory perception of painGO:0019233730.012
single organism intracellular transportGO:19025821660.012
eye developmentGO:0001654500.012
positive regulation of protein metabolic processGO:00512471780.012
leydig cell differentiationGO:003332780.012
cellular response to inorganic substanceGO:0071241650.012
neuron differentiationGO:00301823680.012
growthGO:00400071650.012
renal sodium excretionGO:0035812200.012
regulation of catabolic processGO:00098941130.012
nucleotide catabolic processGO:00091661390.012
nucleoside metabolic processGO:00091161790.012
gland developmentGO:00487321550.012
synaptic growth at neuromuscular junctionGO:005112410.012
bone developmentGO:0060348250.012
peptidyl serine phosphorylationGO:0018105330.012
regulation of smooth muscle contractionGO:0006940290.012
lipid transportGO:0006869610.012
regulation of ion transmembrane transportGO:00347651210.011
immune system processGO:00023762040.011
positive regulation of phosphatidylinositol 3 kinase activityGO:004355220.011
cellular response to oxidative stressGO:0034599760.011
muscle tissue developmentGO:0060537580.011
protein maturationGO:0051604680.011
purine ribonucleoside triphosphate catabolic processGO:00092071220.011
response to woundingGO:00096112540.011
positive regulation of organelle organizationGO:0010638480.011
organic cyclic compound catabolic processGO:19013611750.011
response to tumor necrosis factorGO:0034612560.011
cellular response to growth factor stimulusGO:00713631620.011
heterocycle catabolic processGO:00467001670.011
negative regulation of blood pressureGO:0045776290.011

Dmrta1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.101
disease of anatomical entityDOID:700.101
sensory system diseaseDOID:005015500.043
disease of metabolismDOID:001466700.030
central nervous system diseaseDOID:33100.022
brain diseaseDOID:93600.022
inherited metabolic disorderDOID:65500.017
eye diseaseDOID:561400.012
eye and adnexa diseaseDOID:149200.012