IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Vax1

ventral anterior homeobox 1

RGD: 621132
Ensembl: ENSRNOG00000008824
Entrez: 64571
UniProtKB: Q9JM00

Process Predictions
Disease Predictions

Vax1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
sensory organ development	GO:0007423	74	0.160	Zebrafish Mouse
transcription from rna polymerase ii promoter	GO:0006366	252	0.134	Mouse
ion transmembrane transport	GO:0034220	365	0.118
negative regulation of rna metabolic process	GO:0051253	123	0.101	Mouse
neuron differentiation	GO:0030182	368	0.099	Zebrafish Mouse
calcium ion homeostasis	GO:0055074	162	0.098
brain development	GO:0007420	247	0.097	Mouse
positive regulation of nervous system development	GO:0051962	178	0.092
positive regulation of programmed cell death	GO:0043068	157	0.088
positive regulation of cellular component organization	GO:0051130	200	0.086
transcription dna templated	GO:0006351	377	0.080	Mouse
apoptotic process	GO:0006915	381	0.078	Zebrafish
regulation of ion transport	GO:0043269	245	0.075
response to nutrient levels	GO:0031667	370	0.073
cellular calcium ion homeostasis	GO:0006874	160	0.068
nucleic acid templated transcription	GO:0097659	379	0.067	Mouse
cellular response to oxygen containing compound	GO:1901701	386	0.066
positive regulation of cellular biosynthetic process	GO:0031328	295	0.064
mechanoreceptor differentiation	GO:0042490	2	0.063
positive regulation of apoptotic process	GO:0043065	154	0.063
regulation of cell development	GO:0060284	263	0.062	Zebrafish Mouse
inorganic cation transmembrane transport	GO:0098662	202	0.062
regulation of neurogenesis	GO:0050767	247	0.057	Zebrafish Mouse
regulation of rna metabolic process	GO:0051252	391	0.057	Mouse
cellular component assembly	GO:0022607	360	0.056
rna metabolic process	GO:0016070	406	0.054	Mouse
cellular homeostasis	GO:0019725	252	0.054
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.050	Mouse
cytosolic calcium ion homeostasis	GO:0051480	140	0.049
metal ion transport	GO:0030001	289	0.049
nucleoside phosphate biosynthetic process	GO:1901293	102	0.048
regulation of rna biosynthetic process	GO:2001141	381	0.047	Mouse
cellular ketone metabolic process	GO:0042180	51	0.047
negative regulation of signaling	GO:0023057	157	0.047	Zebrafish
regulation of cellular ketone metabolic process	GO:0010565	27	0.046
positive regulation of phosphorus metabolic process	GO:0010562	262	0.046
neuron projection development	GO:0031175	273	0.045	Zebrafish Mouse
positive regulation of cell death	GO:0010942	184	0.045
regulation of apoptotic process	GO:0042981	335	0.045	Zebrafish
regulation of nervous system development	GO:0051960	264	0.044	Zebrafish Mouse
cation transmembrane transport	GO:0098655	263	0.042
regulation of signal transduction	GO:0009966	318	0.042	Zebrafish
negative regulation of nervous system development	GO:0051961	79	0.042	Mouse
regulation of transcription dna templated	GO:0006355	374	0.041	Mouse
regulation of cellular localization	GO:0060341	263	0.040
response to tumor necrosis factor	GO:0034612	56	0.040
organophosphate metabolic process	GO:0019637	370	0.039
regulation of nucleotide biosynthetic process	GO:0030808	47	0.038
cell projection organization	GO:0030030	302	0.038	Zebrafish Mouse
inorganic ion transmembrane transport	GO:0098660	229	0.038
rna biosynthetic process	GO:0032774	380	0.038	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.037
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.037
regulation of membrane potential	GO:0042391	110	0.036
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.036
regulation of hormone levels	GO:0010817	187	0.036
embryonic skeletal system morphogenesis	GO:0048704	3	0.035
cell migration	GO:0016477	197	0.035	Mouse
negative regulation of macromolecule metabolic process	GO:0010605	260	0.035	Mouse
cellular amine metabolic process	GO:0044106	38	0.035
hair cell differentiation	GO:0035315	2	0.034
regulation of neuron death	GO:1901214	115	0.034
positive regulation of neurogenesis	GO:0050769	165	0.033
positive regulation of gene expression	GO:0010628	244	0.032
regulation of nucleic acid templated transcription	GO:1903506	380	0.031	Mouse
inner ear receptor cell differentiation	GO:0060113	2	0.031
response to oxygen levels	GO:0070482	265	0.031
purine containing compound metabolic process	GO:0072521	253	0.030
positive regulation of cell differentiation	GO:0045597	217	0.030
transmembrane transport	GO:0055085	412	0.030
organic acid transport	GO:0015849	116	0.030
amine metabolic process	GO:0009308	38	0.029
organophosphate biosynthetic process	GO:0090407	143	0.029
reproductive system development	GO:0061458	128	0.029
positive regulation of biosynthetic process	GO:0009891	319	0.029
response to retinoic acid	GO:0032526	63	0.029
hormone secretion	GO:0046879	115	0.028
regulation of neuron differentiation	GO:0045664	208	0.028	Zebrafish
synaptic transmission	GO:0007268	235	0.028
organic acid metabolic process	GO:0006082	292	0.028
purine ribonucleotide metabolic process	GO:0009150	227	0.027
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.027
negative regulation of transport	GO:0051051	136	0.027
reproductive process	GO:0022414	372	0.027
lipid metabolic process	GO:0006629	283	0.027
regulation of neuron projection development	GO:0010975	161	0.027	Zebrafish
regulation of programmed cell death	GO:0043067	341	0.026	Zebrafish
homeostatic process	GO:0042592	331	0.026
neuron development	GO:0048666	286	0.026	Zebrafish Mouse
regulation of cell projection organization	GO:0031344	175	0.026	Zebrafish
head development	GO:0060322	247	0.025	Mouse
cellular amino acid metabolic process	GO:0006520	107	0.025
positive regulation of developmental process	GO:0051094	283	0.025
neuron death	GO:0070997	127	0.025
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.025	Mouse
regulation of system process	GO:0044057	208	0.025
negative regulation of cell communication	GO:0010648	158	0.025	Zebrafish
single organism behavior	GO:0044708	130	0.025
ribonucleotide biosynthetic process	GO:0009260	85	0.024
regulation of cyclic nucleotide metabolic process	GO:0030799	51	0.024
positive regulation of neuron differentiation	GO:0045666	126	0.024
macromolecular complex subunit organization	GO:0043933	339	0.024
cell motility	GO:0048870	202	0.024	Mouse
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.024	Mouse
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.024
programmed cell death	GO:0012501	392	0.024	Zebrafish
cellular metal ion homeostasis	GO:0006875	172	0.024
signal release	GO:0023061	145	0.024
developmental process involved in reproduction	GO:0003006	159	0.024
phospholipid metabolic process	GO:0006644	61	0.023
negative regulation of multicellular organismal process	GO:0051241	203	0.023	Mouse
positive regulation of synaptic transmission	GO:0050806	62	0.023
chemical homeostasis	GO:0048878	292	0.023
aging	GO:0007568	241	0.023
purine nucleotide metabolic process	GO:0006163	229	0.023
protein complex biogenesis	GO:0070271	263	0.023
negative regulation of response to stimulus	GO:0048585	155	0.022	Zebrafish
protein complex assembly	GO:0006461	263	0.022
cation transport	GO:0006812	382	0.022
regulation of secretion	GO:0051046	224	0.022
response to extracellular stimulus	GO:0009991	380	0.022
cell type specific apoptotic process	GO:0097285	134	0.021
negative regulation of transcription dna templated	GO:0045892	116	0.021	Mouse
heterocycle catabolic process	GO:0046700	167	0.021
behavior	GO:0007610	205	0.021	Zebrafish
positive regulation of cell projection organization	GO:0031346	111	0.021
negative regulation of ion transport	GO:0043271	51	0.021
auditory receptor cell differentiation	GO:0042491	2	0.021
regulation of metal ion transport	GO:0010959	118	0.021
regulation of cellular amine metabolic process	GO:0033238	8	0.021
palate development	GO:0060021	2	0.021	Mouse
metal ion homeostasis	GO:0055065	186	0.021
regulation of cellular amino acid metabolic process	GO:0006521	2	0.021
calcium ion transport	GO:0006816	131	0.020
carbohydrate derivative biosynthetic process	GO:1901137	124	0.020
sensory perception of light stimulus	GO:0050953	3	0.020
inflammatory response	GO:0006954	150	0.020
positive regulation of transcription dna templated	GO:0045893	197	0.020
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.020
response to decreased oxygen levels	GO:0036293	237	0.020
regulation of molecular function	GO:0065009	398	0.020
response to acid chemical	GO:0001101	222	0.020
locomotion	GO:0040011	237	0.020	Zebrafish Mouse
positive regulation of rna biosynthetic process	GO:1902680	197	0.019
regulation of locomotion	GO:0040012	148	0.019	Zebrafish
nucleoside phosphate metabolic process	GO:0006753	283	0.019
sexual reproduction	GO:0019953	148	0.019
cellular component movement	GO:0006928	248	0.019	Zebrafish Mouse
positive regulation of molecular function	GO:0044093	230	0.019
positive regulation of ion transport	GO:0043270	94	0.019
regulation of multicellular organismal development	GO:2000026	376	0.019	Zebrafish Mouse
g protein coupled receptor signaling pathway	GO:0007186	242	0.019
second messenger mediated signaling	GO:0019932	51	0.019
response to glucose	GO:0009749	136	0.019
secretion by cell	GO:0032940	248	0.019
ras protein signal transduction	GO:0007265	29	0.019
circadian rhythm	GO:0007623	88	0.019
reproduction	GO:0000003	245	0.019
nitrogen compound transport	GO:0071705	229	0.018
regulation of catecholamine secretion	GO:0050433	32	0.018
sleep	GO:0030431	30	0.018
cell cell signaling	GO:0007267	335	0.018
regulation of purine nucleotide metabolic process	GO:1900542	115	0.018
camera type eye development	GO:0043010	48	0.018	Zebrafish Mouse
ossification	GO:0001503	70	0.018
potassium ion transmembrane transport	GO:0071805	71	0.018
cellular response to nutrient levels	GO:0031669	60	0.018
negative regulation of biosynthetic process	GO:0009890	168	0.018	Mouse
cellular response to lipid	GO:0071396	201	0.018
response to amine	GO:0014075	46	0.018
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.018
positive regulation of rna metabolic process	GO:0051254	203	0.018
mesoderm development	GO:0007498	2	0.017
regulation of transmembrane transport	GO:0034762	122	0.017
circulatory system process	GO:0003013	183	0.017
purine nucleotide biosynthetic process	GO:0006164	83	0.017
peptide transport	GO:0015833	97	0.017
macromolecular complex assembly	GO:0065003	273	0.017
cellular ion homeostasis	GO:0006873	184	0.017
defense response	GO:0006952	194	0.017
negative regulation of neurogenesis	GO:0050768	78	0.017	Mouse
cellular component biogenesis	GO:0044085	368	0.017
carbohydrate derivative metabolic process	GO:1901135	346	0.017
cell adhesion	GO:0007155	110	0.017
cation homeostasis	GO:0055080	195	0.017
memory	GO:0007613	54	0.017
negative regulation of cellular biosynthetic process	GO:0031327	161	0.017	Mouse
cellular response to organonitrogen compound	GO:0071417	197	0.017
positive regulation of cell development	GO:0010720	176	0.017
cellular amide metabolic process	GO:0043603	44	0.016
regulation of lipid metabolic process	GO:0019216	68	0.016
inner ear morphogenesis	GO:0042472	1	0.016
cyclic nucleotide metabolic process	GO:0009187	80	0.016
multicellular organismal reproductive process	GO:0048609	233	0.016
development of primary sexual characteristics	GO:0045137	107	0.016
response to cytokine	GO:0034097	215	0.016
cellular lipid metabolic process	GO:0044255	208	0.016
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.016	Mouse
localization of cell	GO:0051674	202	0.016	Mouse
positive regulation of response to external stimulus	GO:0032103	51	0.016
regulation of circadian sleep wake cycle	GO:0042749	18	0.016
neuron apoptotic process	GO:0051402	88	0.016
organic anion transport	GO:0015711	132	0.016
sequestering of calcium ion	GO:0051208	8	0.016
regulation of synaptic transmission glutamatergic	GO:0051966	26	0.016
blood circulation	GO:0008015	183	0.016
positive regulation of cell proliferation	GO:0008284	249	0.015
divalent inorganic cation transport	GO:0072511	134	0.015
positive regulation of neuron projection development	GO:0010976	99	0.015
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.015	Mouse
nucleotide metabolic process	GO:0009117	279	0.015
hexose transport	GO:0008645	29	0.015
regulation of amine transport	GO:0051952	54	0.015
protein localization	GO:0008104	191	0.015
response to hypoxia	GO:0001666	231	0.015
cellular cation homeostasis	GO:0030003	180	0.015
embryonic skeletal system development	GO:0048706	3	0.015
purine containing compound biosynthetic process	GO:0072522	85	0.015
positive regulation of cellular amine metabolic process	GO:0033240	3	0.015
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	51	0.015
inner ear development	GO:0048839	21	0.015
protein oligomerization	GO:0051259	191	0.015
negative regulation of cell differentiation	GO:0045596	99	0.015	Mouse
cellular catabolic process	GO:0044248	295	0.014
response to growth factor	GO:0070848	189	0.014
response to mechanical stimulus	GO:0009612	134	0.014
eye morphogenesis	GO:0048592	4	0.014	Zebrafish
regulation of cyclic nucleotide biosynthetic process	GO:0030802	45	0.014
ribose phosphate biosynthetic process	GO:0046390	87	0.014
regulation of ion transmembrane transport	GO:0034765	121	0.014
regulation of dendrite development	GO:0050773	59	0.014
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.014	Mouse
response to inorganic substance	GO:0010035	377	0.014
rhythmic process	GO:0048511	156	0.014
peptide hormone secretion	GO:0030072	84	0.014
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.014
carboxylic acid metabolic process	GO:0019752	289	0.014
regulation of protein localization	GO:0032880	81	0.014
monovalent inorganic cation transport	GO:0015672	172	0.014
positive regulation of multicellular organismal process	GO:0051240	387	0.014
divalent inorganic cation homeostasis	GO:0072507	165	0.013
organic substance catabolic process	GO:1901575	316	0.013
negative regulation of gene expression	GO:0010629	199	0.013	Mouse
gonad development	GO:0008406	104	0.013
cellular response to tumor necrosis factor	GO:0071356	46	0.013
cellular potassium ion transport	GO:0071804	72	0.013
purine nucleoside catabolic process	GO:0006152	124	0.013
carboxylic acid transport	GO:0046942	115	0.013
negative regulation of cell death	GO:0060548	229	0.013	Zebrafish
single organism reproductive process	GO:0044702	297	0.013
single organism biosynthetic process	GO:0044711	342	0.013
regulation of cellular component organization	GO:0051128	368	0.013	Zebrafish
skeletal system development	GO:0001501	41	0.013
cyclic purine nucleotide metabolic process	GO:0052652	62	0.013
cellular protein localization	GO:0034613	122	0.013
cellular response to extracellular stimulus	GO:0031668	73	0.013
positive regulation of cellular component biogenesis	GO:0044089	55	0.013
autophagic cell death	GO:0048102	4	0.013
ribonucleotide metabolic process	GO:0009259	231	0.012
cell morphogenesis involved in differentiation	GO:0000904	119	0.012	Zebrafish Mouse
response to axon injury	GO:0048678	59	0.012
regulation of mapk cascade	GO:0043408	116	0.012
single organism organelle organization	GO:1902589	180	0.012
cytoskeleton organization	GO:0007010	111	0.012
potassium ion transport	GO:0006813	97	0.012
peptide secretion	GO:0002790	86	0.012
regulation of synaptic transmission	GO:0050804	141	0.012
positive regulation of signal transduction	GO:0009967	175	0.012
reproductive structure development	GO:0048608	128	0.012
cellular response to nitrogen compound	GO:1901699	210	0.012
negative regulation of natural killer cell mediated immunity	GO:0002716	4	0.012
biological adhesion	GO:0022610	110	0.012
positive regulation of response to stimulus	GO:0048584	285	0.012
regulation of neuron apoptotic process	GO:0043523	83	0.012
regulation of peptide hormone secretion	GO:0090276	80	0.012
phospholipid biosynthetic process	GO:0008654	29	0.012
regulation of phosphorus metabolic process	GO:0051174	349	0.011
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.011	Zebrafish
peptidyl amino acid modification	GO:0018193	126	0.011
regulation of organelle organization	GO:0033043	80	0.011
organic cyclic compound catabolic process	GO:1901361	175	0.011
negative regulation of cellular metabolic process	GO:0031324	281	0.011	Mouse
cellular response to stress	GO:0033554	269	0.011
ameboidal type cell migration	GO:0001667	26	0.011
camp biosynthetic process	GO:0006171	47	0.011
synaptic transmission cholinergic	GO:0007271	11	0.011
gamete generation	GO:0007276	124	0.011
neuron neuron synaptic transmission	GO:0007270	60	0.011
multicellular organism reproduction	GO:0032504	233	0.011
organelle organization	GO:0006996	266	0.011
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.010	Mouse
cellular response to retinoic acid	GO:0071300	27	0.010
hormone metabolic process	GO:0042445	69	0.010
ion homeostasis	GO:0050801	212	0.010
cellular response to external stimulus	GO:0071496	118	0.010
cellular response to organic cyclic compound	GO:0071407	202	0.010
urinary tract smooth muscle contraction	GO:0014848	4	0.010
cellular response to acid chemical	GO:0071229	75	0.010
multi organism reproductive process	GO:0044703	262	0.010
regulation of calcium ion transport	GO:0051924	77	0.010
ear development	GO:0043583	21	0.010
regulation of cell proliferation	GO:0042127	359	0.010	Mouse
gastrulation	GO:0007369	2	0.010
cyclic nucleotide biosynthetic process	GO:0009190	63	0.010
regulation of phosphate metabolic process	GO:0019220	349	0.010
response to carbohydrate	GO:0009743	183	0.010
cellular chemical homeostasis	GO:0055082	247	0.010
positive regulation of long term synaptic potentiation	GO:1900273	4	0.010
muscle cell apoptotic process	GO:0010657	30	0.010

Vax1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.044
disease of anatomical entity	DOID:7	0.044
sensory system disease	DOID:0050155	0.035
cardiovascular system disease	DOID:1287	0.019
disease of metabolism	DOID:0014667	0.012
eye and adnexa disease	DOID:1492	0.010
eye disease	DOID:5614	0.010

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