Rattus norvegicus

152 known processes

Comt

catechol-O-methyltransferase

Comt biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
carboxylic acid metabolic processGO:00197522890.336
organic acid metabolic processGO:00060822920.224
cellular response to peptide hormone stimulusGO:00713751200.211
oxoacid metabolic processGO:00434362900.179
cellular response to endogenous stimulusGO:00714953770.120
response to peptideGO:19016522920.113
response to nutrient levelsGO:00316673700.113
response to metal ionGO:00100382530.110
cellular amino acid metabolic processGO:00065201070.108
cellular response to organonitrogen compoundGO:00714171970.107
cellular response to hormone stimulusGO:00328702470.103
cellular response to peptideGO:19016531330.093
response to peptide hormoneGO:00434342780.092
cellular response to oxygen containing compoundGO:19017013860.090
response to extracellular stimulusGO:00099913800.087
response to inorganic substanceGO:00100353770.082
regulation of transcription from rna polymerase ii promoterGO:00063572340.081
cellular response to nitrogen compoundGO:19016992100.079
response to insulinGO:00328681330.076
cellular component assemblyGO:00226073600.074
lipid metabolic processGO:00066292830.070
cellular lipid metabolic processGO:00442552080.069
regulation of programmed cell deathGO:00430673410.069
regulation of cell proliferationGO:00421273590.069
cellular response to stressGO:00335542690.068
response to glucocorticoidGO:00513842230.067
positive regulation of nitrogen compound metabolic processGO:00511733340.065
macromolecule localizationGO:00330362520.063
positive regulation of biosynthetic processGO:00098913190.062
macromolecular complex subunit organizationGO:00439333390.062
rna biosynthetic processGO:00327743800.061
monocarboxylic acid metabolic processGO:00327871520.060
regulation of nucleic acid templated transcriptionGO:19035063800.060
response to ketoneGO:19016541820.060
anatomical structure morphogenesisGO:00096532980.059
neuron projection developmentGO:00311752730.059
nucleic acid templated transcriptionGO:00976593790.059
cellular component biogenesisGO:00440853680.059
cellular catabolic processGO:00442482950.059
macromolecular complex assemblyGO:00650032730.058
oxidation reduction processGO:00551143040.058
intracellular signal transductionGO:00355563140.056
organic substance catabolic processGO:19015753160.056
transcription dna templatedGO:00063513770.055
regulation of transcription dna templatedGO:00063553740.054
fatty acid metabolic processGO:0006631990.054
catabolic processGO:00090563510.054
regulation of rna biosynthetic processGO:20011413810.054
response to corticosteroidGO:00319602350.053
neuron developmentGO:00486662860.053
positive regulation of developmental processGO:00510942830.052
cellular response to organic cyclic compoundGO:00714072020.052
regulation of cell differentiationGO:00455953200.052
cellular amine metabolic processGO:0044106380.051
response to nutrientGO:00075842480.051
neuron differentiationGO:00301823680.051
response to oxidative stressGO:00069791860.050
response to lipopolysaccharideGO:00324961910.049
protein phosphorylationGO:00064683450.049
transcription from rna polymerase ii promoterGO:00063662520.049
regulation of cellular amine metabolic processGO:003323880.049
cellular response to insulin stimulusGO:0032869810.048
regulation of molecular functionGO:00650093980.047
cell projection organizationGO:00300303020.047
rna metabolic processGO:00160704060.047
reproductive processGO:00224143720.046
positive regulation of nucleobase containing compound metabolic processGO:00459353190.045
regulation of multicellular organismal developmentGO:20000263760.045
regulation of apoptotic processGO:00429813350.044
response to carbohydrateGO:00097431830.044
small molecule biosynthetic processGO:00442831240.044
neurological system processGO:00508772190.044
cellular ketone metabolic processGO:0042180510.043
response to molecule of bacterial originGO:00022371940.043
ion transmembrane transportGO:00342203650.043
brain developmentGO:00074202470.043
positive regulation of macromolecule biosynthetic processGO:00105572470.042
agingGO:00075682410.042
apoptotic processGO:00069153810.041
regulation of rna metabolic processGO:00512523910.041
protein complex biogenesisGO:00702712630.041
transmembrane transportGO:00550854120.040
cation transportGO:00068123820.040
response to biotic stimulusGO:00096072260.040
regulation of cellular ketone metabolic processGO:0010565270.040
negative regulation of cell deathGO:00605482290.039
single organism biosynthetic processGO:00447113420.039
multicellular organismal reproductive processGO:00486092330.039
positive regulation of rna biosynthetic processGO:19026801970.039
regulation of cellular component organizationGO:00511283680.039
protein complex subunit organizationGO:00718223020.039
response to woundingGO:00096112540.038
regulation of hormone levelsGO:00108171870.038
amine metabolic processGO:0009308380.038
central nervous system developmentGO:00074173110.038
cation homeostasisGO:00550801950.038
immune system processGO:00023762040.038
regulation of signal transductionGO:00099663180.038
organelle organizationGO:00069962660.038
cellular response to external stimulusGO:00714961180.038
negative regulation of cellular metabolic processGO:00313242810.037
regulation of cellular amino acid metabolic processGO:000652120.037
positive regulation of cellular biosynthetic processGO:00313282950.037
response to external biotic stimulusGO:00432072210.036
organic acid biosynthetic processGO:0016053830.036
regenerationGO:00310991630.036
regulation of protein metabolic processGO:00512462890.036
protein oligomerizationGO:00512591910.036
regulation of cell developmentGO:00602842630.036
response to amino acidGO:0043200750.036
cellular response to lipidGO:00713962010.036
response to cytokineGO:00340972150.035
positive regulation of cell deathGO:00109421840.035
single organism reproductive processGO:00447022970.035
response to decreased oxygen levelsGO:00362932370.035
lipid biosynthetic processGO:00086101280.035
response to monosaccharideGO:00342841590.035
positive regulation of cell communicationGO:00106472710.035
cellular component morphogenesisGO:00329891550.035
response to acid chemicalGO:00011012220.034
nucleobase containing small molecule metabolic processGO:00550863160.034
growthGO:00400071650.034
regulation of phosphorus metabolic processGO:00511743490.034
regulation of catalytic activityGO:00507903040.034
response to other organismGO:00517072200.034
peptidyl tyrosine modificationGO:0018212720.034
head developmentGO:00603222470.034
regulation of secretionGO:00510462240.033
multicellular organism reproductionGO:00325042330.033
response to bacteriumGO:00096172000.033
regulation of system processGO:00440572080.033
secretionGO:00469033070.033
regulation of phosphate metabolic processGO:00192203490.033
peptidyl amino acid modificationGO:00181931260.032
positive regulation of nucleic acid templated transcriptionGO:19035081970.032
positive regulation of catalytic activityGO:00430851840.032
reproductive structure developmentGO:00486081280.032
positive regulation of transportGO:00510502450.031
response to hypoxiaGO:00016662310.031
cellular chemical homeostasisGO:00550822470.031
positive regulation of gene expressionGO:00106282440.031
regulation of membrane potentialGO:00423911100.031
positive regulation of cellular amine metabolic processGO:003324030.031
establishment of protein localizationGO:00451841410.031
enzyme linked receptor protein signaling pathwayGO:00071671160.031
blood circulationGO:00080151830.031
positive regulation of rna metabolic processGO:00512542030.030
negative regulation of metabolic processGO:00098923310.030
protein complex assemblyGO:00064612630.030
carbohydrate metabolic processGO:00059751300.029
positive regulation of cell proliferationGO:00082842490.029
negative regulation of programmed cell deathGO:00430691830.029
response to estrogenGO:00436272320.029
positive regulation of signalingGO:00230562700.029
negative regulation of cellular biosynthetic processGO:00313271610.029
organophosphate metabolic processGO:00196373700.029
negative regulation of macromolecule metabolic processGO:00106052600.028
gland developmentGO:00487321550.028
cell cell signalingGO:00072673350.028
reproductionGO:00000032450.028
regulation of cellular localizationGO:00603412630.028
regulation of blood circulationGO:19035221100.028
circulatory system processGO:00030131830.028
positive regulation of cellular component organizationGO:00511302000.028
response to ethanolGO:00454711620.028
response to glucoseGO:00097491360.027
cell morphogenesisGO:00009021420.027
positive regulation of response to stimulusGO:00485842850.027
regulation of cellular protein metabolic processGO:00322682670.027
homeostatic processGO:00425923310.027
regulation of organelle organizationGO:0033043800.027
anion transportGO:00068201780.027
positive regulation of multicellular organismal processGO:00512403870.027
alcohol metabolic processGO:0006066770.027
positive regulation of cell differentiationGO:00455972170.027
secretion by cellGO:00329402480.027
single organism catabolic processGO:00447122830.026
cellular modified amino acid metabolic processGO:0006575610.026
positive regulation of transcription dna templatedGO:00458931970.026
programmed cell deathGO:00125013920.026
carboxylic acid biosynthetic processGO:0046394830.026
regulation of transmembrane transportGO:00347621220.026
organonitrogen compound biosynthetic processGO:19015661670.025
negative regulation of response to stimulusGO:00485851550.025
response to hexoseGO:00097461440.025
metal ion transportGO:00300012890.025
regulation of phosphorylationGO:00423252480.025
ion homeostasisGO:00508012120.025
response to oxygen levelsGO:00704822650.025
organic anion transportGO:00157111320.025
cellular response to growth factor stimulusGO:00713631620.025
single organism cellular localizationGO:19025801020.025
chemical homeostasisGO:00488782920.025
response to estradiolGO:00323551640.025
regulation of neuron deathGO:19012141150.024
cellular component movementGO:00069282480.024
reproductive system developmentGO:00614581280.024
response to tumor necrosis factorGO:0034612560.024
positive regulation of apoptotic processGO:00430651540.024
tube developmentGO:0035295890.024
positive regulation of protein metabolic processGO:00512471780.024
protein localizationGO:00081041910.024
positive regulation of molecular functionGO:00440932300.024
cellular response to tumor necrosis factorGO:0071356460.024
peptidyl tyrosine phosphorylationGO:0018108720.023
tissue developmentGO:00098882520.023
response to starvationGO:0042594590.023
developmental process involved in reproductionGO:00030061590.023
response to toxic substanceGO:00096361330.023
regulation of secretion by cellGO:19035302080.023
negative regulation of multicellular organismal processGO:00512412030.023
regulation of anatomical structure sizeGO:00900661350.023
intracellular transportGO:00469071850.023
regulation of nervous system developmentGO:00519602640.023
response to transition metal nanoparticleGO:19902671220.023
positive regulation of cell developmentGO:00107201760.022
cell morphogenesis involved in differentiationGO:00009041190.022
regulation of protein modification processGO:00313991940.022
cellular response to cytokine stimulusGO:00713451270.022
regulation of intracellular signal transductionGO:19025312180.022
multi organism reproductive processGO:00447032620.022
regulation of protein phosphorylationGO:00019321830.022
nitrogen compound transportGO:00717052290.022
regulation of ion transportGO:00432692450.022
liver developmentGO:0001889900.022
protein heterooligomerizationGO:0051291890.021
response to alkaloidGO:00432791320.021
carbohydrate derivative metabolic processGO:19011353460.021
cellular homeostasisGO:00197252520.021
nucleoside phosphate metabolic processGO:00067532830.021
response to growth factorGO:00708481890.021
positive regulation of phosphorus metabolic processGO:00105622620.021
biological adhesionGO:00226101100.021
small gtpase mediated signal transductionGO:0007264360.021
regulation of neurogenesisGO:00507672470.021
regulation of transferase activityGO:00513381230.020
organonitrogen compound catabolic processGO:19015651790.020
organic hydroxy compound metabolic processGO:19016151150.020
cellular response to glucocorticoid stimulusGO:0071385680.020
positive regulation of phosphorylationGO:00423271770.020
positive regulation of signal transductionGO:00099671750.020
single organism organelle organizationGO:19025891800.020
negative regulation of cell proliferationGO:00082851190.020
cell part morphogenesisGO:00329901230.020
cellular protein localizationGO:00346131220.020
sex differentiationGO:00075481130.020
purine containing compound metabolic processGO:00725212530.020
rhythmic processGO:00485111560.019
negative regulation of apoptotic processGO:00430661810.019
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.019
defense responseGO:00069521940.019
regulation of response to stressGO:00801341260.019
positive regulation of phosphate metabolic processGO:00459372620.019
regulation of anatomical structure morphogenesisGO:00226031410.019
positive regulation of programmed cell deathGO:00430681570.019
protein transportGO:00150311320.019
negative regulation of nucleobase containing compound metabolic processGO:00459341530.019
ras protein signal transductionGO:0007265290.019
neuron apoptotic processGO:0051402880.019
positive regulation of cellular protein metabolic processGO:00322701670.019
negative regulation of cell communicationGO:00106481580.019
cell morphogenesis involved in neuron differentiationGO:00486671060.019
nucleotide metabolic processGO:00091172790.019
gastrulationGO:000736920.019
cation transmembrane transportGO:00986552630.019
gonad developmentGO:00084061040.019
eye morphogenesisGO:004859240.018
regulation of immune system processGO:00026821230.018
heart morphogenesisGO:000300730.018
negative regulation of transcription dna templatedGO:00458921160.018
axis specificationGO:000979840.018
negative regulation of biosynthetic processGO:00098901680.018
cellular ion homeostasisGO:00068731840.018
cellular response to abiotic stimulusGO:0071214850.018
positive regulation of nervous system developmentGO:00519621780.018
cellular amide metabolic processGO:0043603440.018
purine nucleoside metabolic processGO:00422781690.018
gamete generationGO:00072761240.018
locomotionGO:00400112370.018
ribose phosphate metabolic processGO:00196932350.017
synaptic growth at neuromuscular junctionGO:005112410.017
action potentialGO:0001508540.017
development of primary sexual characteristicsGO:00451371070.017
regulation of neuron projection developmentGO:00109751610.017
steroid metabolic processGO:0008202730.017
protein autophosphorylationGO:0046777660.017
regulation of response to external stimulusGO:00321011060.017
synaptic transmissionGO:00072682350.017
cellular response to steroid hormone stimulusGO:0071383930.017
negative regulation of macromolecule biosynthetic processGO:00105581480.017
cellular cation homeostasisGO:00300031800.017
chromosome segregationGO:000705920.017
positive regulation of cellular amino acid metabolic processGO:004576410.017
hepaticobiliary system developmentGO:0061008900.017
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.017
single organism intracellular transportGO:19025821660.017
behaviorGO:00076102050.017
protein homooligomerizationGO:0051260910.017
organophosphate biosynthetic processGO:00904071430.017
negative regulation of nitrogen compound metabolic processGO:00511721610.017
negative regulation of rna biosynthetic processGO:19026791180.016
regulation of ion transmembrane transportGO:00347651210.016
membrane organizationGO:0061024940.016
inflammatory responseGO:00069541500.016
urogenital system developmentGO:0001655780.016
response to purine containing compoundGO:00140741260.016
organic cyclic compound catabolic processGO:19013611750.016
anterior posterior pattern specificationGO:000995210.016
regulation of metal ion transportGO:00109591180.016
regulation of cell projection organizationGO:00313441750.016
positive regulation of protein modification processGO:00314011420.016
positive regulation of protein phosphorylationGO:00019341350.016
sensory perceptionGO:00076001010.016
neuronal action potentialGO:0019228350.016
cellular response to alcoholGO:0097306870.016
cellular response to corticosteroid stimulusGO:0071384690.016
immune responseGO:00069551040.016
heart processGO:0003015570.016
inorganic ion transmembrane transportGO:00986602290.016
regulation of growthGO:00400081050.016
regulation of neuron differentiationGO:00456642080.016
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.016
regulation of lipid metabolic processGO:0019216680.016
single organism carbohydrate metabolic processGO:00447231180.016
positive regulation of triglyceride biosynthetic processGO:001086740.016
phospholipid metabolic processGO:0006644610.016
neuron projection morphogenesisGO:00488121220.016
regulation of neuron apoptotic processGO:0043523830.016
peptide biosynthetic processGO:004304330.015
regulation of protein localizationGO:0032880810.015
heterocycle catabolic processGO:00467001670.015
positive regulation of intracellular signal transductionGO:19025331380.015
neuron deathGO:00709971270.015
cell type specific apoptotic processGO:00972851340.015
cellular metal ion homeostasisGO:00068751720.015
cell adhesionGO:00071551100.015
cytoplasmic transportGO:00164821150.015
sexual reproductionGO:00199531480.015
cell projection morphogenesisGO:00488581230.015
cellular response to extracellular stimulusGO:0031668730.015
response to vitaminGO:00332731310.015
negative regulation of nucleic acid templated transcriptionGO:19035071170.015
cellular macromolecule localizationGO:00707271220.015
anatomical structure formation involved in morphogenesisGO:0048646830.015
axon developmentGO:0061564960.015
regulation of homeostatic processGO:00328441010.015
negative regulation of transportGO:00510511360.015
embryonic pattern specificationGO:000988010.015
renal system developmentGO:0072001670.015
divalent metal ion transportGO:00708381320.015
negative regulation of gene expressionGO:00106291990.015
cellular response to oxidative stressGO:0034599760.015
kidney developmentGO:0001822670.015
metal ion homeostasisGO:00550651860.014
response to radiationGO:00093141370.014
positive regulation of neurogenesisGO:00507691650.014
cellular response to nutrient levelsGO:0031669600.014
negative regulation of molecular functionGO:00440921330.014
response to reactive oxygen speciesGO:00003021200.014
cell growthGO:00160491040.014
regulation of kinase activityGO:00435491170.014
nucleobase containing compound catabolic processGO:00346551520.014
negative regulation of cellular component organizationGO:0051129830.014
cellular nitrogen compound catabolic processGO:00442701630.014
signal releaseGO:00230611450.014
response to organophosphorusGO:00466831020.013
localization of cellGO:00516742020.013
calcium ion homeostasisGO:00550741620.013
tumor necrosis factor mediated signaling pathwayGO:003320940.013
alpha amino acid metabolic processGO:1901605710.013
forebrain developmentGO:0030900980.013
actin filament based processGO:0030029860.013
regulation of blood pressureGO:0008217830.013
axonogenesisGO:0007409710.013
response to temperature stimulusGO:0009266940.013
negative regulation of signalingGO:00230571570.013
cellular response to ketoneGO:1901655510.013
chemosensory behaviorGO:000763520.013
regulation of immunoglobulin productionGO:000263740.013
organ morphogenesisGO:0009887750.013
organic acid transportGO:00158491160.013
acute inflammatory responseGO:0002526580.013
proteolysisGO:00065081750.013
rho protein signal transductionGO:0007266110.013
inorganic cation transmembrane transportGO:00986622020.013
response to hydrogen peroxideGO:0042542890.013
negative regulation of rna metabolic processGO:00512531230.013
regulation of catabolic processGO:00098941130.013
purine ribonucleotide metabolic processGO:00091502270.013
ribonucleotide metabolic processGO:00092592310.013
cellular response to reactive oxygen speciesGO:0034614550.012
single organism membrane organizationGO:0044802740.012
cell motilityGO:00488702020.012
multicellular organism growthGO:003526410.012
multicellular organismal signalingGO:0035637440.012
negative regulation of cellular protein metabolic processGO:00322691060.012
exocytosisGO:0006887600.012
carboxylic acid transportGO:00469421150.012
heart contractionGO:0060047570.012
monocarboxylic acid biosynthetic processGO:0072330480.012
divalent inorganic cation homeostasisGO:00725071650.012
monovalent inorganic cation transportGO:00156721720.012
negative regulation of phosphorus metabolic processGO:0010563800.012
intracellular protein transportGO:0006886790.012
hormone secretionGO:00468791150.012
nucleoside metabolic processGO:00091161790.012
negative regulation of phosphate metabolic processGO:0045936800.012
cytokine productionGO:0001816610.012
glycosyl compound metabolic processGO:19016571820.012
positive regulation of cell projection organizationGO:00313461110.012
ribonucleoside metabolic processGO:00091191740.012
regulation of cell morphogenesisGO:0022604770.012
regulation of cytokine productionGO:0001817560.012
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.012
divalent inorganic cation transportGO:00725111340.012
dna metabolic processGO:0006259960.012
purine nucleotide metabolic processGO:00061632290.012
hormone transportGO:00099141210.012
transmission of nerve impulseGO:0019226420.012
regulation of cell growthGO:0001558850.012
wound healingGO:00420601220.012
organ regenerationGO:00311001010.012
blood vessel developmentGO:0001568690.011
regulation of protein transportGO:0051223680.011
erythrocyte differentiationGO:003021810.011
positive regulation of immunoglobulin productionGO:000263940.011
regulation of body fluid levelsGO:0050878900.011
cell cycleGO:00070491010.011
cellular response to mechanical stimulusGO:0071260480.011
gliogenesisGO:0042063930.011
male gamete generationGO:0048232990.011
positive regulation of secretion by cellGO:19035321280.011
cellular calcium ion homeostasisGO:00068741600.011
epithelium developmentGO:0060429960.011
carbohydrate derivative catabolic processGO:19011361470.011
spermatogenesisGO:0007283990.011
negative regulation of catalytic activityGO:00430861030.011
vesicle mediated transportGO:00161921810.011
salivary gland developmentGO:000743130.011
reactive oxygen species metabolic processGO:0072593370.011
amide transportGO:00428861050.011
single organism behaviorGO:00447081300.010
spindle organizationGO:000705120.010
negative regulation of immune system processGO:0002683390.010
negative regulation of protein metabolic processGO:00512481140.010
cellular response to molecule of bacterial originGO:0071219560.010
monosaccharide metabolic processGO:0005996610.010
negative regulation of developmental processGO:00510931250.010
peptide transportGO:0015833970.010
negative regulation of neurogenesisGO:0050768780.010
glial cell differentiationGO:0010001650.010
regulation of establishment of protein localizationGO:0070201690.010
cellular hormone metabolic processGO:0034754490.010
lipid transportGO:0006869610.010
regulation of synaptic transmissionGO:00508041410.010
cell migrationGO:00164771970.010
regulation of blood vessel sizeGO:0050880890.010
calcium ion transportGO:00068161310.010
circulatory system developmentGO:00723591340.010

Comt disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.042
disease of anatomical entityDOID:700.026
nervous system diseaseDOID:86300.026
central nervous system diseaseDOID:33100.015
inherited metabolic disorderDOID:65500.014
musculoskeletal system diseaseDOID:1700.013