Rattus norvegicus

162 known processes

Chn2

chimerin (chimaerin) 2

Chn2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of molecular functionGO:00650093980.187
protein complex subunit organizationGO:00718223020.178
regulation of signal transductionGO:00099663180.170
cellular component assemblyGO:00226073600.160
organic substance catabolic processGO:19015753160.152
cellular component biogenesisGO:00440853680.149
carbohydrate derivative metabolic processGO:19011353460.128
organelle organizationGO:00069962660.127
positive regulation of multicellular organismal processGO:00512403870.125
organic acid metabolic processGO:00060822920.125
oxoacid metabolic processGO:00434362900.121
catabolic processGO:00090563510.121
regulation of phosphate metabolic processGO:00192203490.113
regulation of intracellular signal transductionGO:19025312180.113
homeostatic processGO:00425923310.113
positive regulation of signalingGO:00230562700.111
intracellular signal transductionGO:00355563140.108
aromatic compound catabolic processGO:00194391680.108
positive regulation of developmental processGO:00510942830.104
reproductive processGO:00224143720.104
positive regulation of transportGO:00510502450.101
regulation of programmed cell deathGO:00430673410.101
regulation of phosphorylationGO:00423252480.099
single organism catabolic processGO:00447122830.098
synaptic transmissionGO:00072682350.096
nucleobase containing small molecule metabolic processGO:00550863160.095
positive regulation of phosphate metabolic processGO:00459372620.093
programmed cell deathGO:00125013920.092
carboxylic acid metabolic processGO:00197522890.091
g protein coupled receptor signaling pathwayGO:00071862420.089
macromolecule localizationGO:00330362520.087
organophosphate metabolic processGO:00196373700.087
cellular amino acid metabolic processGO:00065201070.086
organonitrogen compound catabolic processGO:19015651790.085
multicellular organism reproductionGO:00325042330.082
regulation of phosphorus metabolic processGO:00511743490.080
nucleotide metabolic processGO:00091172790.080
neurological system processGO:00508772190.080
vesicle mediated transportGO:00161921810.079
chemical homeostasisGO:00488782920.078
ribonucleoside metabolic processGO:00091191740.074
regulation of synaptic transmissionGO:00508041410.073
positive regulation of nitrogen compound metabolic processGO:00511733340.072
neuron developmentGO:00486662860.072
cellular response to oxygen containing compoundGO:19017013860.070
metal ion homeostasisGO:00550651860.070
positive regulation of nucleoside metabolic processGO:0045979550.070
regulation of protein modification processGO:00313991940.069
ribose phosphate metabolic processGO:00196932350.069
endocytosisGO:0006897840.069
ion homeostasisGO:00508012120.068
biological adhesionGO:00226101100.068
protein localizationGO:00081041910.068
positive regulation of phosphorus metabolic processGO:00105622620.067
lipid metabolic processGO:00066292830.067
positive regulation of cell communicationGO:00106472710.066
regulation of protein phosphorylationGO:00019321830.066
protein phosphorylationGO:00064683450.066
neuron differentiationGO:00301823680.066
amine metabolic processGO:0009308380.065
head developmentGO:00603222470.065
metal ion transportGO:00300012890.064
rna biosynthetic processGO:00327743800.064
organophosphate catabolic processGO:00464341480.063
cell cell signalingGO:00072673350.063
macromolecular complex subunit organizationGO:00439333390.061
rna metabolic processGO:00160704060.061
regulation of kinase activityGO:00435491170.061
multi organism reproductive processGO:00447032620.060
regulation of cellular component organizationGO:00511283680.060
single organism reproductive processGO:00447022970.059
single organism membrane organizationGO:0044802740.059
positive regulation of catalytic activityGO:00430851840.058
negative regulation of signalingGO:00230571570.057
regulation of synaptic transmission glutamatergicGO:0051966260.057
central nervous system developmentGO:00074173110.057
single organism organelle organizationGO:19025891800.056
purine ribonucleoside metabolic processGO:00461281680.055
regulation of apoptotic processGO:00429813350.054
apoptotic processGO:00069153810.054
purine nucleoside triphosphate metabolic processGO:00091441410.053
transmembrane transportGO:00550854120.053
cell type specific apoptotic processGO:00972851340.053
regulation of rna biosynthetic processGO:20011413810.053
regulation of cell differentiationGO:00455953200.053
cellular catabolic processGO:00442482950.053
cellular amine metabolic processGO:0044106380.053
nucleotide catabolic processGO:00091661390.052
multicellular organismal reproductive processGO:00486092330.052
positive regulation of cellular component organizationGO:00511302000.052
membrane organizationGO:0061024940.051
secretionGO:00469033070.051
macromolecular complex assemblyGO:00650032730.050
behaviorGO:00076102050.050
neuron projection developmentGO:00311752730.049
reproductionGO:00000032450.049
regulation of cellular amino acid metabolic processGO:000652120.049
nucleoside triphosphate metabolic processGO:00091411440.049
regulation of cellular amine metabolic processGO:003323880.048
purine containing compound catabolic processGO:00725231380.048
heterocycle catabolic processGO:00467001670.048
positive regulation of cellular protein metabolic processGO:00322701670.048
positive regulation of response to stimulusGO:00485842850.047
brain developmentGO:00074202470.047
ribonucleoside triphosphate catabolic processGO:00092031220.047
cellular chemical homeostasisGO:00550822470.047
anatomical structure morphogenesisGO:00096532980.046
cytoskeleton organizationGO:00070101110.046
nucleobase containing compound catabolic processGO:00346551520.046
purine ribonucleotide metabolic processGO:00091502270.046
multi multicellular organism processGO:00447061380.046
purine ribonucleoside catabolic processGO:00461301240.045
purine nucleoside metabolic processGO:00422781690.045
positive regulation of protein phosphorylationGO:00019341350.045
purine nucleoside triphosphate catabolic processGO:00091461220.045
monocarboxylic acid metabolic processGO:00327871520.044
cellular component morphogenesisGO:00329891550.044
cellular homeostasisGO:00197252520.044
cell part morphogenesisGO:00329901230.044
positive regulation of cell differentiationGO:00455972170.044
positive regulation of intracellular signal transductionGO:19025331380.044
nucleoside catabolic processGO:00091641260.043
single organism cellular localizationGO:19025801020.043
positive regulation of molecular functionGO:00440932300.042
sexual reproductionGO:00199531480.042
mapk cascadeGO:00001651400.042
protein complex biogenesisGO:00702712630.042
regulation of protein metabolic processGO:00512462890.042
regulation of transcription dna templatedGO:00063553740.042
regulation of nervous system developmentGO:00519602640.041
regulation of catalytic activityGO:00507903040.041
purine nucleotide metabolic processGO:00061632290.040
secretion by cellGO:00329402480.040
cell projection organizationGO:00300303020.040
positive regulation of protein metabolic processGO:00512471780.040
cellular ion homeostasisGO:00068731840.040
cellular lipid metabolic processGO:00442552080.039
cellular response to stressGO:00335542690.039
positive regulation of programmed cell deathGO:00430681570.039
carbohydrate derivative catabolic processGO:19011361470.039
negative regulation of transcription dna templatedGO:00458921160.039
organic cyclic compound catabolic processGO:19013611750.039
regulation of cellular ketone metabolic processGO:0010565270.038
regulation of secretion by cellGO:19035302080.038
negative regulation of transportGO:00510511360.036
protein complex assemblyGO:00064612630.035
cellular ketone metabolic processGO:0042180510.035
purine containing compound metabolic processGO:00725212530.035
monovalent inorganic cation transportGO:00156721720.035
purine nucleoside catabolic processGO:00061521240.035
cellular divalent inorganic cation homeostasisGO:00725031620.034
negative regulation of metabolic processGO:00098923310.034
regulation of cell proliferationGO:00421273590.034
positive regulation of cytosolic calcium ion concentrationGO:00072041220.034
nucleoside triphosphate catabolic processGO:00091431230.034
cellular nitrogen compound catabolic processGO:00442701630.034
positive regulation of signal transductionGO:00099671750.034
regulation of multicellular organismal developmentGO:20000263760.034
nucleoside metabolic processGO:00091161790.033
regulation of secretionGO:00510462240.033
response to transition metal nanoparticleGO:19902671220.033
response to inorganic substanceGO:00100353770.033
organonitrogen compound biosynthetic processGO:19015661670.033
negative regulation of apoptotic processGO:00430661810.033
nucleoside phosphate metabolic processGO:00067532830.033
cation homeostasisGO:00550801950.032
positive regulation of cellular biosynthetic processGO:00313282950.032
nucleoside phosphate catabolic processGO:19012921400.031
ribonucleotide metabolic processGO:00092592310.031
regulation of cellular localizationGO:00603412630.031
small molecule biosynthetic processGO:00442831240.031
regulation of cell projection organizationGO:00313441750.031
peptidyl amino acid modificationGO:00181931260.031
regulation of neuron projection developmentGO:00109751610.031
purine ribonucleotide catabolic processGO:00091541360.031
purine nucleotide catabolic processGO:00061951360.031
glycosyl compound metabolic processGO:19016571820.031
negative regulation of gene expressionGO:00106291990.031
positive regulation of protein modification processGO:00314011420.031
regulation of anatomical structure sizeGO:00900661350.031
developmental process involved in reproductionGO:00030061590.030
regulation of cellular protein metabolic processGO:00322682670.030
small gtpase mediated signal transductionGO:0007264360.030
ion transmembrane transportGO:00342203650.030
protein localization to membraneGO:0072657360.030
regulation of nucleic acid templated transcriptionGO:19035063800.030
regulation of neuron differentiationGO:00456642080.029
purine ribonucleoside triphosphate metabolic processGO:00092051400.029
positive regulation of phosphorylationGO:00423271770.029
ribonucleotide catabolic processGO:00092611360.029
positive regulation of cell deathGO:00109421840.029
negative regulation of programmed cell deathGO:00430691830.029
positive regulation of biosynthetic processGO:00098913190.029
cellular component movementGO:00069282480.029
cell morphogenesis involved in differentiationGO:00009041190.029
response to metal ionGO:00100382530.029
regulation of neuron deathGO:19012141150.028
rhythmic processGO:00485111560.028
ribonucleoside catabolic processGO:00424541260.028
cell projection morphogenesisGO:00488581230.028
regulation of ion transportGO:00432692450.028
locomotionGO:00400112370.028
regulation of behaviorGO:0050795610.027
cellular response to organonitrogen compoundGO:00714171970.027
positive regulation of cell projection organizationGO:00313461110.027
regulation of system processGO:00440572080.027
intracellular transportGO:00469071850.027
negative regulation of cell communicationGO:00106481580.027
cell morphogenesisGO:00009021420.027
regulation of cell developmentGO:00602842630.026
divalent inorganic cation homeostasisGO:00725071650.026
positive regulation of protein kinase activityGO:0045860730.026
establishment of tissue polarityGO:000716420.026
sensory perceptionGO:00076001010.026
organelle localizationGO:0051640550.026
positive regulation of cellular amine metabolic processGO:003324030.026
single organism biosynthetic processGO:00447113420.026
positive regulation of apoptotic processGO:00430651540.026
carboxylic acid biosynthetic processGO:0046394830.026
cell morphogenesis involved in neuron differentiationGO:00486671060.026
response to purine containing compoundGO:00140741260.026
cell adhesionGO:00071551100.025
potassium ion transportGO:0006813970.025
positive regulation of cellular amino acid metabolic processGO:004576410.025
positive regulation of cell proliferationGO:00082842490.025
regulation of membrane potentialGO:00423911100.025
nucleic acid templated transcriptionGO:00976593790.025
organic hydroxy compound transportGO:0015850770.025
positive regulation of macromolecule biosynthetic processGO:00105572470.025
positive regulation of gene expressionGO:00106282440.024
positive regulation of secretionGO:00510471400.024
regulation of neurogenesisGO:00507672470.024
cellular cation homeostasisGO:00300031800.024
gamete generationGO:00072761240.024
regulation of proteasomal protein catabolic processGO:006113640.024
response to organophosphorusGO:00466831020.024
regulation of protein kinase activityGO:00458591050.024
neurotransmitter gated ion channel clusteringGO:007257830.024
small molecule catabolic processGO:0044282590.024
actin filament based processGO:0030029860.024
divalent metal ion transportGO:00708381320.023
response to nutrient levelsGO:00316673700.023
regulation of mapk cascadeGO:00434081160.023
glycerolipid metabolic processGO:0046486670.023
ribonucleoside triphosphate metabolic processGO:00091991410.023
regulation of vesicle mediated transportGO:0060627810.023
organic acid biosynthetic processGO:0016053830.023
purine ribonucleoside triphosphate catabolic processGO:00092071220.023
neuron apoptotic processGO:0051402880.023
positive regulation of triglyceride biosynthetic processGO:001086740.023
cellular response to hormone stimulusGO:00328702470.023
cation transmembrane transportGO:00986552630.023
transcription dna templatedGO:00063513770.023
calcium ion homeostasisGO:00550741620.023
cation transportGO:00068123820.023
olfactory learningGO:000835510.023
inorganic ion transmembrane transportGO:00986602290.022
cellular response to nitrogen compoundGO:19016992100.022
cellular metal ion homeostasisGO:00068751720.022
embryonic pattern specificationGO:000988010.022
nitrogen compound transportGO:00717052290.022
establishment of protein localizationGO:00451841410.022
anion transportGO:00068201780.022
positive regulation of cell motilityGO:2000147970.022
positive regulation of nucleobase containing compound metabolic processGO:00459353190.021
cofactor metabolic processGO:0051186950.021
neuron projection morphogenesisGO:00488121220.021
regulation of metal ion transportGO:00109591180.021
cytosolic calcium ion homeostasisGO:00514801400.021
circadian rhythmGO:0007623880.021
regulation of hormone levelsGO:00108171870.021
ras protein signal transductionGO:0007265290.021
single organism behaviorGO:00447081300.021
cellular macromolecule localizationGO:00707271220.021
regulation of immune system processGO:00026821230.021
positive regulation of locomotionGO:00400171020.021
positive regulation of nucleotide metabolic processGO:0045981910.021
inflammatory responseGO:00069541500.020
alcohol metabolic processGO:0006066770.020
proteolysisGO:00065081750.020
regulation of neuron apoptotic processGO:0043523830.020
response to ketoneGO:19016541820.020
signal transduction by phosphorylationGO:00230141440.020
development of primary sexual characteristicsGO:00451371070.020
regulation of cell growthGO:0001558850.020
blood circulationGO:00080151830.020
multicellular organismal signalingGO:0035637440.020
response to peptide hormoneGO:00434342780.020
axis specificationGO:000979840.020
positive regulation of synaptic transmissionGO:0050806620.020
glycosyl compound catabolic processGO:19016581260.020
circulatory system processGO:00030131830.020
actin cytoskeleton organizationGO:0030036730.020
positive regulation of hydrolase activityGO:0051345860.020
neuron deathGO:00709971270.019
divalent inorganic cation transportGO:00725111340.019
positive regulation of neurogenesisGO:00507691650.019
positive regulation of purine nucleotide metabolic processGO:1900544910.019
regulation of response to stressGO:00801341260.019
cognitionGO:0050890920.019
organic hydroxy compound metabolic processGO:19016151150.019
protein oligomerizationGO:00512591910.019
muscle cell proliferationGO:0033002840.019
positive regulation of transferase activityGO:0051347810.019
positive regulation of gtp catabolic processGO:0033126480.019
adenylate cyclase inhibiting serotonin receptor signaling pathwayGO:000719810.018
response to radiationGO:00093141370.018
response to ethanolGO:00454711620.018
single organism carbohydrate metabolic processGO:00447231180.018
positive regulation of ion transportGO:0043270940.018
regulation of rna metabolic processGO:00512523910.018
positive regulation of mapk cascadeGO:0043410920.018
regulation of smooth muscle cell proliferationGO:0048660750.018
immune system processGO:00023762040.018
negative regulation of cell deathGO:00605482290.018
lipid modificationGO:0030258520.018
reproductive system developmentGO:00614581280.018
regulation of transcription from rna polymerase ii promoterGO:00063572340.018
regulation of transferase activityGO:00513381230.018
cellular response to endogenous stimulusGO:00714953770.018
response to light stimulusGO:0009416520.017
transmission of nerve impulseGO:0019226420.017
positive regulation of purine nucleotide catabolic processGO:0033123530.017
response to peptideGO:19016522920.017
cell growthGO:00160491040.017
cell motilityGO:00488702020.017
negative regulation of mitotic cell cycle phase transitionGO:190199130.017
regulation of growthGO:00400081050.017
regulation of hydrolase activityGO:00513361430.017
alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor clusteringGO:009711320.017
positive regulation of immune system processGO:0002684900.017
regulation of organelle organizationGO:0033043800.017
immune responseGO:00069551040.016
negative regulation of molecular functionGO:00440921330.016
protein homooligomerizationGO:0051260910.016
regulation of catabolic processGO:00098941130.016
lipid biosynthetic processGO:00086101280.016
regulation of cell migrationGO:00303341280.016
single organism cell adhesionGO:0098602460.016
regulation of defense responseGO:0031347680.016
asymmetric protein localizationGO:000810520.016
response to decreased oxygen levelsGO:00362932370.016
response to cytokineGO:00340972150.016
negative regulation of cellular metabolic processGO:00313242810.016
regulation of anatomical structure morphogenesisGO:00226031410.016
agingGO:00075682410.016
alpha amino acid metabolic processGO:1901605710.016
inorganic cation transmembrane transportGO:00986622020.016
response to oxidative stressGO:00069791860.016
multicellular organism growthGO:003526410.016
coenzyme metabolic processGO:0006732860.016
carbohydrate metabolic processGO:00059751300.016
response to monosaccharideGO:00342841590.016
neuromuscular processGO:005090520.016
response to hexoseGO:00097461440.016
chemosensory behaviorGO:000763520.016
regulation of synaptic plasticityGO:0048167700.016
forebrain developmentGO:0030900980.016
regulation of calcium ion transportGO:0051924770.016
hormone secretionGO:00468791150.016
response to acid chemicalGO:00011012220.015
regulation of purine nucleotide metabolic processGO:19005421150.015
neurotransmitter transportGO:0006836420.015
response to glucoseGO:00097491360.015
positive regulation of smooth muscle cell proliferationGO:0048661510.015
cell cell junction organizationGO:0045216200.015
positive regulation of neuron projection developmentGO:0010976990.015
neuronal action potentialGO:0019228350.015
cellular amino acid biosynthetic processGO:0008652320.015
lipid localizationGO:0010876620.015
axonogenesisGO:0007409710.015
gonad developmentGO:00084061040.015
cellular protein localizationGO:00346131220.015
hormone transportGO:00099141210.015
learningGO:0007612330.015
cellular response to acid chemicalGO:0071229750.015
transcription from rna polymerase ii promoterGO:00063662520.015
response to estrogenGO:00436272320.015
positive regulation of secretion by cellGO:19035321280.015
carbohydrate derivative biosynthetic processGO:19011371240.015
anterior posterior pattern specificationGO:000995210.015
negative regulation of phosphorus metabolic processGO:0010563800.015
synaptic vesicle endocytosisGO:004848840.015
sex differentiationGO:00075481130.015
regulation of dendrite developmentGO:0050773590.015
positive regulation of nervous system developmentGO:00519621780.014
positive regulation of cellular catabolic processGO:0031331710.014
taxisGO:0042330670.014
carboxylic acid transportGO:00469421150.014
metanephric comma shaped body morphogenesisGO:007227820.014
associative learningGO:0008306190.014
neural crest cell developmentGO:001403220.014
regulation of body fluid levelsGO:0050878900.014
spermatogenesisGO:0007283990.014
glucose homeostasisGO:0042593750.014
glutamate receptor signaling pathwayGO:0007215430.014
response to ammonium ionGO:0060359710.014
olfactory behaviorGO:004204820.014
hepaticobiliary system developmentGO:0061008900.014
cellular response to alcoholGO:0097306870.014
cellular response to organic cyclic compoundGO:00714072020.014
organophosphate biosynthetic processGO:00904071430.014
establishment of organelle localizationGO:0051656370.014
response to woundingGO:00096112540.014
gtp metabolic processGO:0046039720.014
regulation of locomotionGO:00400121480.014
salivary gland developmentGO:000743130.014
negative regulation of cell cycle phase transitionGO:190198840.014
regulation of nucleotide catabolic processGO:0030811650.014
response to insulinGO:00328681330.014
signal releaseGO:00230611450.014
smooth muscle cell proliferationGO:0048659770.014
synapse assemblyGO:0007416290.014
positive regulation of neuron differentiationGO:00456661260.014
chemotaxisGO:0006935660.013
positive regulation of neuron apoptotic processGO:0043525330.013
negative regulation of macromolecule metabolic processGO:00106052600.013
negative regulation of cell proliferationGO:00082851190.013
gtp catabolic processGO:0006184710.013
regulation of response to external stimulusGO:00321011060.013
cellular calcium ion homeostasisGO:00068741600.013
regulation of nucleotide metabolic processGO:00061401170.013
negative regulation of multicellular organismal processGO:00512412030.013
growthGO:00400071650.013
regulation of canonical wnt signaling pathwayGO:006082840.013
positive regulation of rna biosynthetic processGO:19026801970.013
cellular response to glucocorticoid stimulusGO:0071385680.013
axon developmentGO:0061564960.013
action potentialGO:0001508540.013
vesicle organizationGO:0016050290.013
lipid catabolic processGO:0016042460.013
response to nutrientGO:00075842480.013
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188510.013
morphogenesis of a polarized epitheliumGO:000173810.013
response to glucocorticoidGO:00513842230.013
receptor mediated endocytosisGO:0006898420.013
cell cycle checkpointGO:000007520.013
cellular response to lipidGO:00713962010.013
chromosome segregationGO:000705920.013
rho protein signal transductionGO:0007266110.013
positive regulation of nucleotide catabolic processGO:0030813530.013
negative regulation of macromolecule biosynthetic processGO:00105581480.013
receptor metabolic processGO:0043112180.013
regulation of response to woundingGO:1903034690.013
cytoskeleton dependent cytokinesisGO:006164020.013
carbohydrate homeostasisGO:0033500750.013
muscle system processGO:00030121150.013
synaptic growth at neuromuscular junctionGO:005112410.012
pro t cell differentiationGO:000257210.012
neuromuscular synaptic transmissionGO:000727420.012
axon midline choice point recognitionGO:001619920.012
negative regulation of osteoblast differentiationGO:004566820.012
regulation of endocytosisGO:0030100420.012
astrocyte developmentGO:001400240.012
response to corticosteroidGO:00319602350.012
phospholipid metabolic processGO:0006644610.012
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.012
regulation of cell cycleGO:0051726730.012
ovulation cycleGO:0042698670.012
pseudopodium assemblyGO:003126930.012
neural crest cell migrationGO:000175510.012
regulation of hormone secretionGO:00468831060.012
cell migrationGO:00164771970.012
negative regulation of nitrogen compound metabolic processGO:00511721610.012
negative regulation of biosynthetic processGO:00098901680.012
positive regulation of cellular component movementGO:00512721020.012
developmental growthGO:00485891000.012
positive regulation of cell developmentGO:00107201760.012
negative regulation of signal transductionGO:0009968830.012
response to campGO:0051591910.012
endomembrane system organizationGO:0010256480.012
tube developmentGO:0035295890.012
response to extracellular stimulusGO:00099913800.012
sympathetic nervous system developmentGO:004848510.012
negative regulation of cellular component organizationGO:0051129830.012
response to alkaloidGO:00432791320.012
cellular modified amino acid metabolic processGO:0006575610.012
multicellular organismal homeostasisGO:0048871490.012
response to temperature stimulusGO:0009266940.012
macroautophagyGO:001623640.012
lipid transportGO:0006869610.012
positive regulation of catabolic processGO:0009896780.012

Chn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.030
cancerDOID:16200.025
cardiovascular system diseaseDOID:128700.024
disease of anatomical entityDOID:700.024
vascular diseaseDOID:17800.024
organ system cancerDOID:005068600.022
disease of metabolismDOID:001466700.019
nervous system diseaseDOID:86300.017
gastrointestinal system cancerDOID:311900.016
inherited metabolic disorderDOID:65500.014
central nervous system diseaseDOID:33100.012
connective tissue diseaseDOID:6500.012
musculoskeletal system diseaseDOID:1700.012