IMP: Integrative Multi-species Prediction

Rattus norvegicus

73 known processes

Gata1

GATA binding protein 1

(Aliases: Eryf1)

Ensembl: ENSRNOG00000025534
RGD: 2663
Entrez: 25172
UniProtKB: P43429

Process Predictions
Disease Predictions

Gata1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
reproductive process	GO:0022414	372	0.255
developmental process involved in reproduction	GO:0003006	159	0.203
programmed cell death	GO:0012501	392	0.178	Zebrafish Mouse
regulation of blood pressure	GO:0008217	83	0.175
response to inorganic substance	GO:0010035	377	0.153
regulation of molecular function	GO:0065009	398	0.150
regulation of programmed cell death	GO:0043067	341	0.134	Zebrafish Mouse
response to wounding	GO:0009611	254	0.131	Mouse
immune system process	GO:0002376	204	0.123	Zebrafish Mouse
response to hypoxia	GO:0001666	231	0.117
organic acid metabolic process	GO:0006082	292	0.109
macromolecular complex subunit organization	GO:0043933	339	0.109	Mouse
protein complex subunit organization	GO:0071822	302	0.100
apoptotic process	GO:0006915	381	0.099	Zebrafish Mouse
reactive oxygen species metabolic process	GO:0072593	37	0.099
single organism reproductive process	GO:0044702	297	0.090
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.090	Zebrafish Mouse
renal system process	GO:0003014	40	0.087
macromolecular complex assembly	GO:0065003	273	0.087
nitrogen compound transport	GO:0071705	229	0.085
response to extracellular stimulus	GO:0009991	380	0.083
multicellular organism reproduction	GO:0032504	233	0.080
multicellular organismal reproductive process	GO:0048609	233	0.079
oxoacid metabolic process	GO:0043436	290	0.079
anatomical structure morphogenesis	GO:0009653	298	0.078	Mouse
protein complex assembly	GO:0006461	263	0.078
multi organism reproductive process	GO:0044703	262	0.078
cellular response to stress	GO:0033554	269	0.070
regulation of transcription dna templated	GO:0006355	374	0.064	Zebrafish Mouse
negative regulation of gene expression	GO:0010629	199	0.063	Zebrafish Mouse
protein complex biogenesis	GO:0070271	263	0.062
negative regulation of metabolic process	GO:0009892	331	0.062	Zebrafish Mouse
rna biosynthetic process	GO:0032774	380	0.059	Zebrafish Mouse
positive regulation of transport	GO:0051050	245	0.059
cellular response to oxygen containing compound	GO:1901701	386	0.059
development of primary sexual characteristics	GO:0045137	107	0.059
reproductive system development	GO:0061458	128	0.057
single organism biosynthetic process	GO:0044711	342	0.057
cellular chemical homeostasis	GO:0055082	247	0.056
positive regulation of phosphate metabolic process	GO:0045937	262	0.056	Mouse
regulation of phosphorus metabolic process	GO:0051174	349	0.054	Mouse
regulation of signal transduction	GO:0009966	318	0.052
sexual reproduction	GO:0019953	148	0.048
negative regulation of cell death	GO:0060548	229	0.047	Zebrafish Mouse
carboxylic acid biosynthetic process	GO:0046394	83	0.047
positive regulation of multicellular organismal process	GO:0051240	387	0.046
multi multicellular organism process	GO:0044706	138	0.046
tissue development	GO:0009888	252	0.045
reproductive structure development	GO:0048608	128	0.045
response to hexose	GO:0009746	144	0.044
response to vitamin	GO:0033273	131	0.044
positive regulation of cellular biosynthetic process	GO:0031328	295	0.043	Zebrafish Mouse
organophosphate biosynthetic process	GO:0090407	143	0.042
positive regulation of phosphorus metabolic process	GO:0010562	262	0.042	Mouse
organ morphogenesis	GO:0009887	75	0.041
carbohydrate derivative metabolic process	GO:1901135	346	0.041	Mouse
cellular response to endogenous stimulus	GO:0071495	377	0.040
organophosphate metabolic process	GO:0019637	370	0.040
regulation of protein metabolic process	GO:0051246	289	0.037	Mouse
positive regulation of developmental process	GO:0051094	283	0.037
response to metal ion	GO:0010038	253	0.037
response to increased oxygen levels	GO:0036296	45	0.037
male gonad development	GO:0008584	59	0.036
male sex differentiation	GO:0046661	64	0.036
carboxylic acid metabolic process	GO:0019752	289	0.036
cellular component assembly	GO:0022607	360	0.036
response to carbohydrate	GO:0009743	183	0.036
circulatory system process	GO:0003013	183	0.035
organic acid biosynthetic process	GO:0016053	83	0.034
positive regulation of cell communication	GO:0010647	271	0.033
muscle system process	GO:0003012	115	0.033
organic anion transport	GO:0015711	132	0.033
small gtpase mediated signal transduction	GO:0007264	36	0.032
reproduction	GO:0000003	245	0.032
intracellular signal transduction	GO:0035556	314	0.032
lipid biosynthetic process	GO:0008610	128	0.032
small molecule biosynthetic process	GO:0044283	124	0.032
cation transport	GO:0006812	382	0.032
regulation of rna biosynthetic process	GO:2001141	381	0.032	Zebrafish Mouse
response to cytokine	GO:0034097	215	0.032
regulation of response to stress	GO:0080134	126	0.031
ossification	GO:0001503	70	0.031	Mouse
cellular component biogenesis	GO:0044085	368	0.031
cytoskeleton organization	GO:0007010	111	0.031
response to transition metal nanoparticle	GO:1990267	122	0.030
regulation of immune system process	GO:0002682	123	0.029	Zebrafish Mouse
defecation	GO:0030421	1	0.029
regulation of cell proliferation	GO:0042127	359	0.029	Mouse
regulation of apoptotic process	GO:0042981	335	0.029	Zebrafish Mouse
cell cycle	GO:0007049	101	0.029
positive regulation of gene expression	GO:0010628	244	0.029	Zebrafish Mouse
positive regulation of molecular function	GO:0044093	230	0.028
organic hydroxy compound transport	GO:0015850	77	0.028
cellular response to oxidative stress	GO:0034599	76	0.028
protein heterooligomerization	GO:0051291	89	0.028
regulation of nucleic acid templated transcription	GO:1903506	380	0.028	Zebrafish Mouse
cell activation	GO:0001775	97	0.027	Mouse
cellular ion homeostasis	GO:0006873	184	0.027
tissue remodeling	GO:0048771	40	0.027
response to nutrient levels	GO:0031667	370	0.027
carbohydrate metabolic process	GO:0005975	130	0.027
cardiovascular system development	GO:0072358	134	0.027
single organism carbohydrate metabolic process	GO:0044723	118	0.027
macromolecule localization	GO:0033036	252	0.027
transcription from rna polymerase ii promoter	GO:0006366	252	0.026	Zebrafish Mouse
head development	GO:0060322	247	0.026
positive regulation of homeostatic process	GO:0032846	49	0.026
regulation of system process	GO:0044057	208	0.026
amine transport	GO:0015837	57	0.025
response to glucose	GO:0009749	136	0.025
response to decreased oxygen levels	GO:0036293	237	0.025
insulin like growth factor receptor signaling pathway	GO:0048009	3	0.025
negative regulation of multicellular organismal process	GO:0051241	203	0.025	Mouse
regulation of intracellular signal transduction	GO:1902531	218	0.025
antibiotic transport	GO:0042891	2	0.025
cellular response to organonitrogen compound	GO:0071417	197	0.025
negative regulation of macromolecule metabolic process	GO:0010605	260	0.025	Zebrafish Mouse
response to camp	GO:0051591	91	0.025
rna metabolic process	GO:0016070	406	0.024	Zebrafish Mouse
positive regulation of biosynthetic process	GO:0009891	319	0.024	Zebrafish Mouse
aging	GO:0007568	241	0.024
gland development	GO:0048732	155	0.024
regulation of ion transport	GO:0043269	245	0.024
chemical homeostasis	GO:0048878	292	0.023
excretion	GO:0007588	24	0.023
sex differentiation	GO:0007548	113	0.023
positive regulation of blood coagulation	GO:0030194	4	0.023
cellular homeostasis	GO:0019725	252	0.023
neuronal action potential	GO:0019228	35	0.023
regulation of anatomical structure size	GO:0090066	135	0.023
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.023	Zebrafish Mouse
regulation of body fluid levels	GO:0050878	90	0.023	Mouse
negative regulation of programmed cell death	GO:0043069	183	0.023	Zebrafish Mouse
signal transduction by phosphorylation	GO:0023014	144	0.022
ras protein signal transduction	GO:0007265	29	0.022
negative regulation of cell proliferation	GO:0008285	119	0.022	Mouse
nucleotide metabolic process	GO:0009117	279	0.022
lipid metabolic process	GO:0006629	283	0.022
positive regulation of catalytic activity	GO:0043085	184	0.022
lipid transport	GO:0006869	61	0.022
cellular lipid metabolic process	GO:0044255	208	0.022
positive regulation of cell proliferation	GO:0008284	249	0.022	Mouse
central nervous system development	GO:0007417	311	0.022
organonitrogen compound biosynthetic process	GO:1901566	167	0.021
embryo development	GO:0009790	49	0.021	Zebrafish Mouse
response to oxygen levels	GO:0070482	265	0.021
positive regulation of signal transduction	GO:0009967	175	0.021
regulation of cellular protein metabolic process	GO:0032268	267	0.021	Mouse
organic acid transport	GO:0015849	116	0.021
positive regulation of immune system process	GO:0002684	90	0.021
negative regulation of protein metabolic process	GO:0051248	114	0.021
regulation of synaptic transmission	GO:0050804	141	0.021
response to mineralocorticoid	GO:0051385	49	0.021
cell morphogenesis involved in differentiation	GO:0000904	119	0.020	Mouse
regulation of hormone levels	GO:0010817	187	0.020
cellular response to hormone stimulus	GO:0032870	247	0.020
tongue morphogenesis	GO:0043587	3	0.020
cellular response to reactive oxygen species	GO:0034614	55	0.020
positive regulation of response to stimulus	GO:0048584	285	0.020
bmp signaling pathway	GO:0030509	4	0.020
regulation of catalytic activity	GO:0050790	304	0.020
cellular amine metabolic process	GO:0044106	38	0.020
positive regulation of signaling	GO:0023056	270	0.020
regulation of epithelial cell proliferation	GO:0050678	49	0.020
wound healing	GO:0042060	122	0.020	Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.019	Zebrafish Mouse
response to peptide hormone	GO:0043434	278	0.019
response to axon injury	GO:0048678	59	0.019
response to mechanical stimulus	GO:0009612	134	0.019
nucleocytoplasmic transport	GO:0006913	48	0.019
response to oxidative stress	GO:0006979	186	0.019
spindle organization	GO:0007051	2	0.018
positive regulation of cellular component organization	GO:0051130	200	0.018
cellular response to peptide	GO:1901653	133	0.018
protein oligomerization	GO:0051259	191	0.018
response to acid chemical	GO:0001101	222	0.018
stress activated protein kinase signaling cascade	GO:0031098	37	0.018
cell type specific apoptotic process	GO:0097285	134	0.017
regulation of cellular component organization	GO:0051128	368	0.017
eye morphogenesis	GO:0048592	4	0.017
neuron differentiation	GO:0030182	368	0.017
regulation of rna metabolic process	GO:0051252	391	0.017	Zebrafish Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.017
lipid localization	GO:0010876	62	0.017
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.017	Zebrafish Mouse
mapk cascade	GO:0000165	140	0.017
homeostatic process	GO:0042592	331	0.016	Zebrafish Mouse
intracellular transport	GO:0046907	185	0.016
response to radiation	GO:0009314	137	0.016
positive regulation of rna metabolic process	GO:0051254	203	0.016	Zebrafish Mouse
immune response	GO:0006955	104	0.016
response to bacterium	GO:0009617	200	0.016
nucleoside phosphate metabolic process	GO:0006753	283	0.016
synaptic transmission	GO:0007268	235	0.016
regulation of excretion	GO:0044062	21	0.016
response to insulin	GO:0032868	133	0.016
transmembrane transport	GO:0055085	412	0.016
female pregnancy	GO:0007565	122	0.016
regulation of phosphate metabolic process	GO:0019220	349	0.015	Mouse
multicellular organismal homeostasis	GO:0048871	49	0.015
transmission of nerve impulse	GO:0019226	42	0.015
ensheathment of neurons	GO:0007272	40	0.015
positive regulation of cellular amine metabolic process	GO:0033240	3	0.015
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.015
negative regulation of follicle stimulating hormone secretion	GO:0046882	3	0.015
vesicle mediated transport	GO:0016192	181	0.015
positive regulation of nucleotide metabolic process	GO:0045981	91	0.015
response to monosaccharide	GO:0034284	159	0.015
anion transmembrane transport	GO:0098656	77	0.015
positive regulation of extracellular matrix organization	GO:1903055	4	0.015
cellular response to mechanical stimulus	GO:0071260	48	0.015
gamete generation	GO:0007276	124	0.015
calcium ion transport	GO:0006816	131	0.015
cell projection organization	GO:0030030	302	0.015
transcription dna templated	GO:0006351	377	0.014	Zebrafish Mouse
anion transport	GO:0006820	178	0.014
axis specification	GO:0009798	4	0.014
regulation of cellular amine metabolic process	GO:0033238	8	0.014
cytoplasmic transport	GO:0016482	115	0.014
growth	GO:0040007	165	0.014
regulation of response to wounding	GO:1903034	69	0.014
multicellular organismal signaling	GO:0035637	44	0.014
positive regulation of phosphorylation	GO:0042327	177	0.014	Mouse
response to estradiol	GO:0032355	164	0.014
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.013	Mouse
response to biotic stimulus	GO:0009607	226	0.013
ion homeostasis	GO:0050801	212	0.013
amine metabolic process	GO:0009308	38	0.013
carbohydrate derivative biosynthetic process	GO:1901137	124	0.013	Mouse
monocarboxylic acid biosynthetic process	GO:0072330	48	0.013
regulation of cellular amino acid metabolic process	GO:0006521	2	0.013
cellular response to glucose stimulus	GO:0071333	65	0.013
response to interleukin 1	GO:0070555	55	0.013
regulation of cellular ketone metabolic process	GO:0010565	27	0.013
positive regulation of programmed cell death	GO:0043068	157	0.013
purine containing compound metabolic process	GO:0072521	253	0.013
olfactory behavior	GO:0042048	2	0.013
cellular ketone metabolic process	GO:0042180	51	0.013
regulation of multicellular organismal development	GO:2000026	376	0.013	Zebrafish Mouse
regulation of homeostatic process	GO:0032844	101	0.013	Mouse
g protein coupled receptor signaling pathway	GO:0007186	242	0.012
positive regulation of cell differentiation	GO:0045597	217	0.012
response to estrogen	GO:0043627	232	0.012
regulation of angiogenesis	GO:0045765	39	0.012
cognition	GO:0050890	92	0.012
ion transmembrane transport	GO:0034220	365	0.012
monocarboxylic acid transport	GO:0015718	52	0.012
establishment of protein localization	GO:0045184	141	0.012
cellular response to nitrogen compound	GO:1901699	210	0.012
protein maturation	GO:0051604	68	0.012
cellular response to hexose stimulus	GO:0071331	65	0.012
neuron projection development	GO:0031175	273	0.012
rho protein signal transduction	GO:0007266	11	0.012
regulation of bmp signaling pathway	GO:0030510	2	0.012
regulation of anion transport	GO:0044070	43	0.011
glycerol transport	GO:0015793	2	0.011
positive regulation of protein metabolic process	GO:0051247	178	0.011	Mouse
cellular metal ion homeostasis	GO:0006875	172	0.011
exploration behavior	GO:0035640	1	0.011
response to purine containing compound	GO:0014074	126	0.011
cell motility	GO:0048870	202	0.011
phospholipid metabolic process	GO:0006644	61	0.011
response to fatty acid	GO:0070542	65	0.011
negative regulation of apoptotic process	GO:0043066	181	0.011	Zebrafish Mouse
response to reactive oxygen species	GO:0000302	120	0.011
neuron projection morphogenesis	GO:0048812	122	0.011
ribonucleotide metabolic process	GO:0009259	231	0.011
one carbon compound transport	GO:0019755	5	0.011
locomotory exploration behavior	GO:0035641	1	0.011
embryonic pattern specification	GO:0009880	1	0.011
single organism organelle organization	GO:1902589	180	0.011
development of primary male sexual characteristics	GO:0046546	59	0.011
stress activated mapk cascade	GO:0051403	35	0.011
cellular response to peptide hormone stimulus	GO:0071375	120	0.011
secretion	GO:0046903	307	0.011
generation of precursor metabolites and energy	GO:0006091	62	0.011
cellular response to steroid hormone stimulus	GO:0071383	93	0.011
regulation of defecation	GO:2000292	1	0.011
actin filament depolymerization	GO:0030042	3	0.011
cytokine production	GO:0001816	61	0.011
mitotic spindle organization	GO:0007052	2	0.011
smooth muscle cell proliferation	GO:0048659	77	0.010
cellular catabolic process	GO:0044248	295	0.010
negative regulation of defecation	GO:2000293	1	0.010
organic substance catabolic process	GO:1901575	316	0.010
behavior	GO:0007610	205	0.010
gonad development	GO:0008406	104	0.010
regulation of systemic arterial blood pressure	GO:0003073	30	0.010
regulation of cell differentiation	GO:0045595	320	0.010	Zebrafish Mouse
positive regulation of necrotic cell death	GO:0010940	4	0.010

Gata1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.065
urinary system disease	DOID:18	0.064
disease of anatomical entity	DOID:7	0.064
cancer	DOID:162	0.033
organ system cancer	DOID:0050686	0.030
disease of metabolism	DOID:0014667	0.019
inherited metabolic disorder	DOID:655	0.019
nervous system disease	DOID:863	0.018
endocrine system disease	DOID:28	0.016
sensory system disease	DOID:0050155	0.012
central nervous system disease	DOID:331	0.012
cardiovascular system disease	DOID:1287	0.011

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