IMP: Integrative Multi-species Prediction

Rattus norvegicus

100 known processes

Fgf2

fibroblast growth factor 2

(Aliases: Fgf-2,bFGF)

Entrez: 54250
RGD: 2609
Ensembl: ENSRNOG00000017392
UniProtKB: P13109

Process Predictions
Disease Predictions

Fgf2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of cellular component movement	GO:0051270	150	0.926	Mouse Worm
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	51	0.750
mapk cascade	GO:0000165	140	0.545	Mouse Rat
neurological system process	GO:0050877	219	0.525
regulation of behavior	GO:0050795	61	0.460	Worm
cellular metal ion homeostasis	GO:0006875	172	0.447
regulation of anatomical structure size	GO:0090066	135	0.436	Worm
locomotion	GO:0040011	237	0.427	Mouse Worm
response to mechanical stimulus	GO:0009612	134	0.420
cellular cation homeostasis	GO:0030003	180	0.413
regulation of locomotion	GO:0040012	148	0.384	Mouse Worm
regulation of secretion	GO:0051046	224	0.378
g protein coupled receptor signaling pathway	GO:0007186	242	0.356
regulation of blood pressure	GO:0008217	83	0.355
localization of cell	GO:0051674	202	0.350	Mouse
response to extracellular stimulus	GO:0009991	380	0.350
regulation of hormone secretion	GO:0046883	106	0.331
chemical homeostasis	GO:0048878	292	0.330	Rat
regulation of blood vessel size	GO:0050880	89	0.328
defense response	GO:0006952	194	0.321
behavior	GO:0007610	205	0.317	Worm
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.305
synaptic transmission	GO:0007268	235	0.303
wound healing	GO:0042060	122	0.293
regulation of anatomical structure morphogenesis	GO:0022603	141	0.287	Mouse Rat Worm
reproduction	GO:0000003	245	0.280	Rat
positive regulation of multicellular organismal process	GO:0051240	387	0.265
cellular response to organic cyclic compound	GO:0071407	202	0.259
cellular ion homeostasis	GO:0006873	184	0.251
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.242
adenylate cyclase inhibiting g protein coupled receptor signaling pathway	GO:0007193	19	0.239
vascular process in circulatory system	GO:0003018	96	0.232
organic substance catabolic process	GO:1901575	316	0.229
ion homeostasis	GO:0050801	212	0.224	Rat
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.218
apoptotic process	GO:0006915	381	0.208
macromolecular complex assembly	GO:0065003	273	0.208
positive regulation of long term synaptic potentiation	GO:1900273	4	0.207
calcium ion homeostasis	GO:0055074	162	0.207
cation transport	GO:0006812	382	0.205	Rat
positive regulation of transport	GO:0051050	245	0.202
positive regulation of signaling	GO:0023056	270	0.200	Mouse Rat
cation homeostasis	GO:0055080	195	0.200
response to wounding	GO:0009611	254	0.198
multi organism reproductive process	GO:0044703	262	0.194
regulation of saliva secretion	GO:0046877	3	0.194
aging	GO:0007568	241	0.191
response to molecule of bacterial origin	GO:0002237	194	0.189	Rat
regulation of cell motility	GO:2000145	131	0.188	Mouse
regulation of tube size	GO:0035150	89	0.183
cellular component biogenesis	GO:0044085	368	0.178
regulation of hormone levels	GO:0010817	187	0.177
protein complex biogenesis	GO:0070271	263	0.174
regulation of ion transport	GO:0043269	245	0.173	Rat
positive regulation of secretion by cell	GO:1903532	128	0.170
divalent inorganic cation homeostasis	GO:0072507	165	0.169
cellular chemical homeostasis	GO:0055082	247	0.167
cellular response to growth factor stimulus	GO:0071363	162	0.167
blood circulation	GO:0008015	183	0.167
positive regulation of response to stimulus	GO:0048584	285	0.165	Mouse Rat
response to growth factor	GO:0070848	189	0.165
homeostatic process	GO:0042592	331	0.162	Rat
response to alkaloid	GO:0043279	132	0.161
head development	GO:0060322	247	0.157	Mouse
regulation of cell migration	GO:0030334	128	0.156	Mouse
positive regulation of leukocyte migration	GO:0002687	21	0.155
eating behavior	GO:0042755	21	0.153
cellular component assembly	GO:0022607	360	0.151
startle response	GO:0001964	2	0.148
cognition	GO:0050890	92	0.147
positive regulation of cell proliferation	GO:0008284	249	0.146
regulation of angiogenesis	GO:0045765	39	0.145	Mouse
cellular response to lipid	GO:0071396	201	0.145
blood vessel development	GO:0001568	69	0.144
cellular calcium ion homeostasis	GO:0006874	160	0.143
metal ion homeostasis	GO:0055065	186	0.143
urinary bladder smooth muscle contraction	GO:0014832	4	0.140
cellular component movement	GO:0006928	248	0.139	Mouse Worm
response to carbohydrate	GO:0009743	183	0.139
positive regulation of cell communication	GO:0010647	271	0.137	Mouse Rat
monovalent inorganic cation transport	GO:0015672	172	0.136	Rat
single organism behavior	GO:0044708	130	0.136
organic acid transport	GO:0015849	116	0.136
response to estrogen	GO:0043627	232	0.132	Rat
tissue development	GO:0009888	252	0.131
leukocyte migration	GO:0050900	38	0.130
positive regulation of phosphate metabolic process	GO:0045937	262	0.129	Mouse Rat
cell cell signaling	GO:0007267	335	0.128	Mouse Rat
positive regulation of nucleotide metabolic process	GO:0045981	91	0.126
amino acid transport	GO:0006865	70	0.125
cell morphogenesis involved in differentiation	GO:0000904	119	0.125	Worm
sensory perception	GO:0007600	101	0.125
regulation of blood circulation	GO:1903522	110	0.124
synaptic transmission glutamatergic	GO:0035249	33	0.124
nitrogen compound transport	GO:0071705	229	0.118
positive regulation of phosphorus metabolic process	GO:0010562	262	0.116	Mouse Rat
regulation of synaptic transmission glutamatergic	GO:0051966	26	0.116
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.116
protein phosphorylation	GO:0006468	345	0.115	Mouse
regulation of leukocyte migration	GO:0002685	24	0.113
saliva secretion	GO:0046541	3	0.113
single organism reproductive process	GO:0044702	297	0.112	Rat
developmental growth	GO:0048589	100	0.111
regulation of cellular component organization	GO:0051128	368	0.110	Worm
organophosphate metabolic process	GO:0019637	370	0.109	Rat
negative regulation of blood vessel morphogenesis	GO:2000181	10	0.108
anion transport	GO:0006820	178	0.107
divalent inorganic cation transport	GO:0072511	134	0.106
positive regulation of secretion	GO:0051047	140	0.105
regulation of cell proliferation	GO:0042127	359	0.105
organic anion transport	GO:0015711	132	0.103
response to glucocorticoid	GO:0051384	223	0.103
regulation of cellular localization	GO:0060341	263	0.102
regulation of synaptic transmission	GO:0050804	141	0.102
temperature homeostasis	GO:0001659	17	0.101
transmembrane transport	GO:0055085	412	0.101	Rat
regulation of multicellular organismal development	GO:2000026	376	0.100
cellular homeostasis	GO:0019725	252	0.099
positive regulation of cell migration	GO:0030335	96	0.098	Mouse
macromolecule localization	GO:0033036	252	0.097
macromolecular complex subunit organization	GO:0043933	339	0.097
positive regulation of ion transport	GO:0043270	94	0.096
adenylate cyclase activating g protein coupled receptor signaling pathway	GO:0007189	24	0.096
ribonucleotide metabolic process	GO:0009259	231	0.096
protein complex subunit organization	GO:0071822	302	0.095
positive regulation of cell motility	GO:2000147	97	0.095	Mouse
neuron differentiation	GO:0030182	368	0.093	Worm
regulation of calcium ion transport	GO:0051924	77	0.092
response to inorganic substance	GO:0010035	377	0.092
organonitrogen compound catabolic process	GO:1901565	179	0.092
cytosolic calcium ion homeostasis	GO:0051480	140	0.092
nucleoside phosphate metabolic process	GO:0006753	283	0.091
response to estradiol	GO:0032355	164	0.091	Rat
reproductive process	GO:0022414	372	0.090	Rat
positive regulation of saliva secretion	GO:0046878	3	0.090
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.089
angiogenesis	GO:0001525	53	0.089
regulation of secretion by cell	GO:1903530	208	0.088
positive regulation of nucleoside metabolic process	GO:0045979	55	0.088
heart contraction	GO:0060047	57	0.085
positive regulation of cyclic nucleotide metabolic process	GO:0030801	37	0.084
memory	GO:0007613	54	0.081
hormone transport	GO:0009914	121	0.081
hormone secretion	GO:0046879	115	0.081
ion transmembrane transport	GO:0034220	365	0.080	Rat
multicellular organism reproduction	GO:0032504	233	0.080	Rat
positive regulation of the force of heart contraction by epinephrine	GO:0003059	1	0.079
positive regulation of blood pressure by epinephrine norepinephrine	GO:0003321	2	0.079
muscle contraction	GO:0006936	88	0.078
feeding behavior	GO:0007631	53	0.078
response to toxic substance	GO:0009636	133	0.078
potassium ion transport	GO:0006813	97	0.077
catabolic process	GO:0009056	351	0.077
regulation of growth	GO:0040008	105	0.077
vasodilation	GO:0042311	44	0.076
neuron development	GO:0048666	286	0.076	Worm
secretion	GO:0046903	307	0.075
somatostatin receptor signaling pathway	GO:0038169	4	0.072
cellular response to external stimulus	GO:0071496	118	0.072
renal filtration	GO:0097205	10	0.072
reproductive system development	GO:0061458	128	0.072	Rat
detection of stimulus	GO:0051606	24	0.071
response to nutrient levels	GO:0031667	370	0.071
regulation of system process	GO:0044057	208	0.070
regulation of membrane potential	GO:0042391	110	0.070	Rat
response to lipopolysaccharide	GO:0032496	191	0.070	Rat
brain development	GO:0007420	247	0.070	Mouse
cell motility	GO:0048870	202	0.070	Mouse
regulation of the force of heart contraction by chemical signal	GO:0003057	2	0.069
response to monosaccharide	GO:0034284	159	0.069
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.067	Mouse
positive regulation of immune system process	GO:0002684	90	0.065
programmed cell death	GO:0012501	392	0.065	Mouse
smooth muscle contraction	GO:0006939	37	0.065
positive regulation of behavior	GO:0048520	38	0.065
regulation of smooth muscle contraction	GO:0006940	29	0.064
renal sodium excretion	GO:0035812	20	0.064
cell migration	GO:0016477	197	0.064	Mouse
regulation of vasculature development	GO:1901342	44	0.063	Mouse
synaptic transmission gabaergic	GO:0051932	22	0.063
regulation of response to stress	GO:0080134	126	0.063
phospholipase c activating g protein coupled receptor signaling pathway	GO:0007200	27	0.063
renal system process	GO:0003014	40	0.063
positive regulation of biosynthetic process	GO:0009891	319	0.062	Mouse
regulation of body fluid levels	GO:0050878	90	0.062
regulation of phosphorylation	GO:0042325	248	0.061	Mouse Rat
positive regulation of cell projection organization	GO:0031346	111	0.061
positive regulation of locomotion	GO:0040017	102	0.061	Mouse
regulation of systemic arterial blood pressure	GO:0003073	30	0.061
organonitrogen compound biosynthetic process	GO:1901566	167	0.060	Rat
purine containing compound metabolic process	GO:0072521	253	0.060
positive regulation of mapk cascade	GO:0043410	92	0.059	Mouse Rat
single organism catabolic process	GO:0044712	283	0.059
nucleobase containing compound catabolic process	GO:0034655	152	0.059
positive regulation of response to external stimulus	GO:0032103	51	0.059
divalent metal ion transport	GO:0070838	132	0.058
nucleoside triphosphate metabolic process	GO:0009141	144	0.058
negative regulation of ion transport	GO:0043271	51	0.058	Rat
response to other organism	GO:0051707	220	0.058	Rat
protein complex assembly	GO:0006461	263	0.057
positive regulation of signal transduction	GO:0009967	175	0.057	Mouse Rat
cellular response to mechanical stimulus	GO:0071260	48	0.056
regulation of glutamate secretion	GO:0014048	17	0.056
response to external biotic stimulus	GO:0043207	221	0.056	Rat
purine nucleotide metabolic process	GO:0006163	229	0.056
sensory perception of pain	GO:0019233	73	0.055
camp biosynthetic process	GO:0006171	47	0.055
positive regulation of cellular component movement	GO:0051272	102	0.055	Mouse
regulation of apoptotic process	GO:0042981	335	0.055
regulation of synaptic plasticity	GO:0048167	70	0.054
positive regulation of renal sodium excretion	GO:0035815	10	0.054
metal ion transport	GO:0030001	289	0.054	Rat
response to glucose	GO:0009749	136	0.053
positive regulation of hormone secretion	GO:0046887	65	0.053
detection of abiotic stimulus	GO:0009582	13	0.053
protein localization	GO:0008104	191	0.053
positive regulation of molecular function	GO:0044093	230	0.052	Mouse
cellular response to steroid hormone stimulus	GO:0071383	93	0.052
negative regulation of glutamate secretion	GO:0014050	9	0.051
regulation of postsynaptic membrane potential	GO:0060078	25	0.051
regulation of rna biosynthetic process	GO:2001141	381	0.051	Mouse
regulation of excretion	GO:0044062	21	0.051
growth	GO:0040007	165	0.050
positive regulation of catalytic activity	GO:0043085	184	0.050	Mouse
cellular response to drug	GO:0035690	30	0.049
response to organophosphorus	GO:0046683	102	0.049
neuron neuron synaptic transmission	GO:0007270	60	0.049
multicellular organism growth	GO:0035264	1	0.049
regulation of purine nucleotide metabolic process	GO:1900542	115	0.048
cell activation	GO:0001775	97	0.048
synaptic transmission cholinergic	GO:0007271	11	0.048
positive regulation of developmental process	GO:0051094	283	0.048
anatomical structure morphogenesis	GO:0009653	298	0.048
regulation of kinase activity	GO:0043549	117	0.048	Mouse
regulation of systemic arterial blood pressure by norepinephrine epinephrine	GO:0001993	2	0.048
positive regulation of blood circulation	GO:1903524	65	0.048
purine containing compound biosynthetic process	GO:0072522	85	0.047
reproductive structure development	GO:0048608	128	0.047	Rat
associative learning	GO:0008306	19	0.047
adenylate cyclase inhibiting serotonin receptor signaling pathway	GO:0007198	1	0.046
cellular response to endogenous stimulus	GO:0071495	377	0.046
negative regulation of transport	GO:0051051	136	0.046	Rat
sodium ion homeostasis	GO:0055078	23	0.046
regulation of cell development	GO:0060284	263	0.045	Mouse Worm
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.045
positive regulation of renin secretion into blood stream	GO:1900135	1	0.045
purine ribonucleotide biosynthetic process	GO:0009152	81	0.045
blood vessel morphogenesis	GO:0048514	58	0.045
regulation of vasoconstriction	GO:0019229	44	0.044
neuromuscular process	GO:0050905	2	0.044
response to biotic stimulus	GO:0009607	226	0.044	Rat
regulation of cyclic nucleotide metabolic process	GO:0030799	51	0.044
regulation of defense response	GO:0031347	68	0.043
synapse assembly	GO:0007416	29	0.043
neurological system process involved in regulation of systemic arterial blood pressure	GO:0001976	3	0.043
ras protein signal transduction	GO:0007265	29	0.042
glutamate secretion	GO:0014047	19	0.042
regulation of protein metabolic process	GO:0051246	289	0.042	Mouse
camp metabolic process	GO:0046058	63	0.042
response to mineralocorticoid	GO:0051385	49	0.042
protein heterooligomerization	GO:0051291	89	0.042
positive regulation of smooth muscle contraction	GO:0045987	18	0.042
response to nicotine	GO:0035094	51	0.042
regulation of cell projection organization	GO:0031344	175	0.042	Worm
female pregnancy	GO:0007565	122	0.041
cellular amino acid metabolic process	GO:0006520	107	0.041
ribonucleotide catabolic process	GO:0009261	136	0.041
regulation of protein kinase activity	GO:0045859	105	0.041	Mouse
regulation of cellular amine metabolic process	GO:0033238	8	0.041
calcium ion transport	GO:0006816	131	0.041
cell morphogenesis	GO:0000902	142	0.041	Worm
secretion by cell	GO:0032940	248	0.041
nucleoside catabolic process	GO:0009164	126	0.040
nucleobase containing small molecule metabolic process	GO:0055086	316	0.040
carbohydrate derivative metabolic process	GO:1901135	346	0.040
ribonucleoside catabolic process	GO:0042454	126	0.040
heart process	GO:0003015	57	0.040
detection of external stimulus	GO:0009581	13	0.040
receptor metabolic process	GO:0043112	18	0.040
cellular catabolic process	GO:0044248	295	0.040
negative regulation of vasculature development	GO:1901343	11	0.040
nucleoside phosphate biosynthetic process	GO:1901293	102	0.040
positive regulation of homeostatic process	GO:0032846	49	0.039
developmental process involved in reproduction	GO:0003006	159	0.039	Rat
nucleoside phosphate catabolic process	GO:1901292	140	0.039
response to radiation	GO:0009314	137	0.039
detection of temperature stimulus involved in sensory perception of pain	GO:0050965	4	0.039
central nervous system development	GO:0007417	311	0.039	Mouse
positive regulation of cell differentiation	GO:0045597	217	0.038	Mouse
positive regulation of calcium ion transport	GO:0051928	36	0.038
positive regulation of cellular component organization	GO:0051130	200	0.038
purine ribonucleoside monophosphate metabolic process	GO:0009167	84	0.038
nucleotide metabolic process	GO:0009117	279	0.038
urinary tract smooth muscle contraction	GO:0014848	4	0.038
negative regulation of developmental process	GO:0051093	125	0.037
immune response	GO:0006955	104	0.037
cellular response to extracellular stimulus	GO:0031668	73	0.037
regulation of nucleotide metabolic process	GO:0006140	117	0.037
regulation of cell differentiation	GO:0045595	320	0.037	Mouse Worm
signal transduction by phosphorylation	GO:0023014	144	0.037	Mouse Rat
cellular response to glucocorticoid stimulus	GO:0071385	68	0.037
positive regulation of intracellular signal transduction	GO:1902533	138	0.036	Mouse Rat
regulation of response to wounding	GO:1903034	69	0.036
vasoconstriction	GO:0042310	54	0.036
positive regulation of camp metabolic process	GO:0030816	31	0.036
positive regulation of rna biosynthetic process	GO:1902680	197	0.036	Mouse
ribose phosphate metabolic process	GO:0019693	235	0.036
regulation of programmed cell death	GO:0043067	341	0.036	Mouse
regulation of muscle system process	GO:0090257	79	0.035
regulation of neurogenesis	GO:0050767	247	0.035	Worm
carbohydrate catabolic process	GO:0016052	40	0.035
regulation of intracellular signal transduction	GO:1902531	218	0.035	Mouse Rat
respiratory system process	GO:0003016	3	0.035
forebrain development	GO:0030900	98	0.035	Mouse
response to corticosteroid	GO:0031960	235	0.035
regulation of catabolic process	GO:0009894	113	0.035
regulation of cellular protein metabolic process	GO:0032268	267	0.034	Mouse
organic cyclic compound catabolic process	GO:1901361	175	0.034
regulation of camp biosynthetic process	GO:0030817	38	0.034
circulatory system development	GO:0072359	134	0.034
positive regulation of gene expression	GO:0010628	244	0.034	Mouse
regulation of rna metabolic process	GO:0051252	391	0.034	Mouse
purine ribonucleotide metabolic process	GO:0009150	227	0.034
regulation of transcription dna templated	GO:0006355	374	0.034	Mouse
cell growth	GO:0016049	104	0.034	Worm
regulation of renal sodium excretion	GO:0035813	20	0.034
synaptic growth at neuromuscular junction	GO:0051124	1	0.034
response to purine containing compound	GO:0014074	126	0.034
regulation of signal transduction	GO:0009966	318	0.033	Mouse Rat
regulation of anion transport	GO:0044070	43	0.033
positive regulation of peptide secretion	GO:0002793	52	0.033
negative regulation of synaptic transmission gabaergic	GO:0032229	6	0.033
olfactory learning	GO:0008355	1	0.032
protein oligomerization	GO:0051259	191	0.032
single organism carbohydrate catabolic process	GO:0044724	40	0.032
carboxylic acid transport	GO:0046942	115	0.032
regulation of purine nucleotide biosynthetic process	GO:1900371	46	0.032
regulation of systemic arterial blood pressure by circulatory renin angiotensin	GO:0001991	4	0.032
heterocycle catabolic process	GO:0046700	167	0.032
somatostatin signaling pathway	GO:0038170	4	0.032
prepulse inhibition	GO:0060134	1	0.032
rhythmic process	GO:0048511	156	0.031	Rat
vasodilation by norepinephrine epinephrine involved in regulation of systemic arterial blood pressure	GO:0002025	1	0.031
transcription dna templated	GO:0006351	377	0.031	Mouse
sodium ion transport	GO:0006814	82	0.031	Rat
leukocyte activation	GO:0045321	76	0.031
response to temperature stimulus	GO:0009266	94	0.030
chronic inflammatory response to non antigenic stimulus	GO:0002545	1	0.030
regulation of potassium ion transport	GO:0043266	29	0.030
circadian sleep wake cycle process	GO:0022410	21	0.030
nucleic acid templated transcription	GO:0097659	379	0.030	Mouse
regulation of transferase activity	GO:0051338	123	0.030	Mouse
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.030
positive regulation of the force of heart contraction by epinephrine norepinephrine	GO:0001997	2	0.030
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.030
regulation of purine nucleotide catabolic process	GO:0033121	65	0.030
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.030
cellular macromolecule localization	GO:0070727	122	0.030
renin secretion into blood stream	GO:0002001	1	0.030
cellular response to lipopolysaccharide	GO:0071222	55	0.030
positive regulation of protein phosphorylation	GO:0001934	135	0.030	Mouse
positive regulation of protein kinase activity	GO:0045860	73	0.030	Mouse
cardiovascular system development	GO:0072358	134	0.030
regulation of cellular ketone metabolic process	GO:0010565	27	0.029
regulation of catecholamine secretion	GO:0050433	32	0.029
organophosphate catabolic process	GO:0046434	148	0.029
glycosyl compound catabolic process	GO:1901658	126	0.029
respiratory gaseous exchange	GO:0007585	4	0.029
regulation of amino acid transport	GO:0051955	25	0.029
negative regulation of natural killer cell mediated immunity	GO:0002716	4	0.029
negative regulation of secretion by cell	GO:1903531	72	0.029
cellular response to oxygen containing compound	GO:1901701	386	0.029
carbohydrate derivative catabolic process	GO:1901136	147	0.029
involuntary skeletal muscle contraction	GO:0003011	2	0.028
purine containing compound catabolic process	GO:0072523	138	0.028
signal release	GO:0023061	145	0.028
excretion	GO:0007588	24	0.028
cyclic purine nucleotide metabolic process	GO:0052652	62	0.028
response to cytokine	GO:0034097	215	0.028
negative regulation of response to stimulus	GO:0048585	155	0.028
n methyl d aspartate receptor clustering	GO:0097114	2	0.028
regulation of nucleic acid templated transcription	GO:1903506	380	0.028	Mouse
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.028
regulation of renin secretion into blood stream	GO:1900133	1	0.028
response to camp	GO:0051591	91	0.028
peptide hormone secretion	GO:0030072	84	0.028
positive regulation of phosphorylation	GO:0042327	177	0.028	Mouse Rat
neuron apoptotic process	GO:0051402	88	0.027
ribonucleoside metabolic process	GO:0009119	174	0.027
cellular amine metabolic process	GO:0044106	38	0.027	Rat
positive regulation of cellular biosynthetic process	GO:0031328	295	0.027	Mouse
negative regulation of multicellular organismal process	GO:0051241	203	0.027
l glutamate import	GO:0051938	2	0.027
circulatory system process	GO:0003013	183	0.027
rhythmic behavior	GO:0007622	24	0.027
g protein coupled purinergic receptor signaling pathway	GO:0035588	8	0.027
positive regulation of muscle contraction	GO:0045933	22	0.027
detection of temperature stimulus	GO:0016048	4	0.027
cellular response to transforming growth factor beta stimulus	GO:0071560	41	0.027
regulation of protein phosphorylation	GO:0001932	183	0.026	Mouse
urogenital system development	GO:0001655	78	0.026
learning	GO:0007612	33	0.026
positive regulation of cyclase activity	GO:0031281	15	0.026
action potential	GO:0001508	54	0.026
amine metabolic process	GO:0009308	38	0.026	Rat
learning or memory	GO:0007611	90	0.026
response to hydrogen peroxide	GO:0042542	89	0.026
positive regulation of cellular catabolic process	GO:0031331	71	0.025
telencephalon development	GO:0021537	62	0.025
regulation of muscle tissue development	GO:1901861	25	0.025
response to dexamethasone	GO:0071548	49	0.025
phasic smooth muscle contraction	GO:0014821	3	0.025
negative regulation of natural killer cell mediated cytotoxicity	GO:0045953	4	0.025
cellular nitrogen compound catabolic process	GO:0044270	163	0.025
regulation of catalytic activity	GO:0050790	304	0.025	Mouse
nucleoside monophosphate metabolic process	GO:0009123	93	0.025
synapse organization	GO:0050808	46	0.025
regulation of wound healing	GO:0061041	14	0.025
regulation of nervous system development	GO:0051960	264	0.025	Mouse Worm
inflammatory response	GO:0006954	150	0.024
regulation of response to external stimulus	GO:0032101	106	0.024	Worm
anion transmembrane transport	GO:0098656	77	0.024
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.024
amine transport	GO:0015837	57	0.024
establishment of protein localization	GO:0045184	141	0.024
response to progesterone	GO:0032570	48	0.024
multi multicellular organism process	GO:0044706	138	0.024
multicellular organismal reproductive process	GO:0048609	233	0.024	Rat
regulation of cellular amino acid metabolic process	GO:0006521	2	0.024
peptide secretion	GO:0002790	86	0.024
regulation of hydrolase activity	GO:0051336	143	0.024
muscle system process	GO:0003012	115	0.023
positive regulation of transcription dna templated	GO:0045893	197	0.023	Mouse
purine nucleoside metabolic process	GO:0042278	169	0.023
glycosyl compound metabolic process	GO:1901657	182	0.023
female gonad development	GO:0008585	53	0.023	Rat
negative regulation of innate immune response	GO:0045824	4	0.023
negative regulation of gene expression	GO:0010629	199	0.023
small gtpase mediated signal transduction	GO:0007264	36	0.023
estrous cycle phase	GO:0060206	15	0.023
cellular response to metal ion	GO:0071248	55	0.023
negative regulation of uterine smooth muscle contraction	GO:0070473	2	0.023
response to reactive oxygen species	GO:0000302	120	0.023
negative regulation of macromolecule metabolic process	GO:0010605	260	0.023
purine ribonucleoside metabolic process	GO:0046128	168	0.023
development of primary sexual characteristics	GO:0045137	107	0.023	Rat
nucleoside metabolic process	GO:0009116	179	0.022
peptide transport	GO:0015833	97	0.022
neuron projection morphogenesis	GO:0048812	122	0.022	Worm
inorganic anion transport	GO:0015698	41	0.022
response to transforming growth factor beta	GO:0071559	46	0.022
phospholipase c activating serotonin receptor signaling pathway	GO:0007208	2	0.022
response to nutrient	GO:0007584	248	0.022
purine nucleotide catabolic process	GO:0006195	136	0.022
cellular response to stress	GO:0033554	269	0.022
ribonucleotide biosynthetic process	GO:0009260	85	0.022
immune system process	GO:0002376	204	0.022
intracellular signal transduction	GO:0035556	314	0.021	Mouse Rat
cellular carbohydrate metabolic process	GO:0044262	72	0.021
regulation of mapk cascade	GO:0043408	116	0.021	Mouse Rat
tolerance induction to nonself antigen	GO:0002462	2	0.021
regulation of synaptic transmission gabaergic	GO:0032228	17	0.021
norepinephrine transport	GO:0015874	18	0.021
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	7	0.021
negative regulation of angiogenesis	GO:0016525	10	0.021
acid secretion	GO:0046717	48	0.021
astrocyte development	GO:0014002	4	0.021
purine nucleoside catabolic process	GO:0006152	124	0.021
oxoacid metabolic process	GO:0043436	290	0.021
regulation of immune system process	GO:0002682	123	0.020
response to amine	GO:0014075	46	0.020
positive regulation of blood pressure	GO:0045777	31	0.020
regulation of neuron differentiation	GO:0045664	208	0.020	Worm
locomotory behavior	GO:0007626	15	0.020
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.020
cell projection morphogenesis	GO:0048858	123	0.020	Worm
endocrine process	GO:0050886	32	0.020
cellular response to molecule of bacterial origin	GO:0071219	56	0.020
positive regulation of potassium ion transport	GO:0043268	13	0.020
regulation of metal ion transport	GO:0010959	118	0.020	Rat
negative regulation of cellular metabolic process	GO:0031324	281	0.020
multicellular organismal signaling	GO:0035637	44	0.020
organophosphate biosynthetic process	GO:0090407	143	0.020	Rat
sleep	GO:0030431	30	0.019
negative regulation of wound healing	GO:0061045	8	0.019
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	27	0.019
secretion by tissue	GO:0032941	37	0.019
regulation of muscle contraction	GO:0006937	53	0.019
negative regulation of defense response	GO:0031348	19	0.019
response to electrical stimulus	GO:0051602	56	0.019
negative regulation of homeostatic process	GO:0032845	47	0.019

Fgf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
eye and adnexa disease	DOID:1492	0.064
disease of anatomical entity	DOID:7	0.064
retinal disease	DOID:5679	0.064
sensory system disease	DOID:0050155	0.064
nervous system disease	DOID:863	0.064
eye disease	DOID:5614	0.064
night blindness	DOID:8499	0.030

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