IMP: Integrative Multi-species Prediction

Rattus norvegicus

28 known processes

Ggcx

gamma-glutamyl carboxylase

Entrez: 81716
RGD: 68383
Ensembl: ENSRNOG00000012975
UniProtKB: O88496

Process Predictions
Disease Predictions

Ggcx biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
regulation of catalytic activity	GO:0050790	304	0.163
regulation of protein metabolic process	GO:0051246	289	0.143
peptide metabolic process	GO:0006518	32	0.128
regulation of cellular protein metabolic process	GO:0032268	267	0.116
peptidyl glutamic acid modification	GO:0018200	1	0.103
oxoacid metabolic process	GO:0043436	290	0.100
response to wounding	GO:0009611	254	0.098
organic acid metabolic process	GO:0006082	292	0.093
reproductive process	GO:0022414	372	0.093
negative regulation of metabolic process	GO:0009892	331	0.083
regulation of hydrolase activity	GO:0051336	143	0.081
cellular component assembly	GO:0022607	360	0.075
ossification	GO:0001503	70	0.068
programmed cell death	GO:0012501	392	0.067
cellular response to hormone stimulus	GO:0032870	247	0.066
regulation of molecular function	GO:0065009	398	0.065
single organism biosynthetic process	GO:0044711	342	0.064
regulation of apoptotic process	GO:0042981	335	0.059
regulation of cell development	GO:0060284	263	0.055
positive regulation of cellular biosynthetic process	GO:0031328	295	0.053
positive regulation of signaling	GO:0023056	270	0.052
response to oxygen levels	GO:0070482	265	0.051
wound healing	GO:0042060	122	0.050
cell projection organization	GO:0030030	302	0.050
carbohydrate derivative metabolic process	GO:1901135	346	0.048
positive regulation of gene expression	GO:0010628	244	0.048
regulation of protein transport	GO:0051223	68	0.047
cellular component biogenesis	GO:0044085	368	0.047
macromolecular complex subunit organization	GO:0043933	339	0.046
regulation of response to stress	GO:0080134	126	0.046
tissue development	GO:0009888	252	0.045
positive regulation of signal transduction	GO:0009967	175	0.045
positive regulation of cellular component organization	GO:0051130	200	0.044
positive regulation of phosphorus metabolic process	GO:0010562	262	0.043
regulation of neurogenesis	GO:0050767	247	0.043
purine nucleotide metabolic process	GO:0006163	229	0.042
regulation of phosphorus metabolic process	GO:0051174	349	0.041
organonitrogen compound biosynthetic process	GO:1901566	167	0.040
cell cell signaling	GO:0007267	335	0.040
carbohydrate derivative biosynthetic process	GO:1901137	124	0.039
positive regulation of developmental process	GO:0051094	283	0.039
multicellular organismal reproductive process	GO:0048609	233	0.038
negative regulation of molecular function	GO:0044092	133	0.038
positive regulation of cell communication	GO:0010647	271	0.038
positive regulation of cell death	GO:0010942	184	0.038
carboxylic acid metabolic process	GO:0019752	289	0.038
regulation of cell differentiation	GO:0045595	320	0.037
neuron differentiation	GO:0030182	368	0.035
multicellular organism reproduction	GO:0032504	233	0.034
immune system process	GO:0002376	204	0.034
regulation of body fluid levels	GO:0050878	90	0.034
positive regulation of molecular function	GO:0044093	230	0.033
regulation of secretion	GO:0051046	224	0.033
regeneration	GO:0031099	163	0.033
negative regulation of protein metabolic process	GO:0051248	114	0.033
nucleobase containing small molecule metabolic process	GO:0055086	316	0.032
negative regulation of cellular metabolic process	GO:0031324	281	0.032
developmental process involved in reproduction	GO:0003006	159	0.032
chemical homeostasis	GO:0048878	292	0.031
cellular ketone metabolic process	GO:0042180	51	0.030
glycosaminoglycan biosynthetic process	GO:0006024	4	0.030
positive regulation of catalytic activity	GO:0043085	184	0.030
positive regulation of cellular protein metabolic process	GO:0032270	167	0.029
regulation of anatomical structure morphogenesis	GO:0022603	141	0.029
negative regulation of programmed cell death	GO:0043069	183	0.028
positive regulation of protein metabolic process	GO:0051247	178	0.028
cartilage development involved in endochondral bone morphogenesis	GO:0060351	3	0.028
secretion by cell	GO:0032940	248	0.028
aminoglycan biosynthetic process	GO:0006023	4	0.027
negative regulation of cell death	GO:0060548	229	0.027
regulation of phosphate metabolic process	GO:0019220	349	0.027
negative regulation of macromolecule metabolic process	GO:0010605	260	0.027
response to acid chemical	GO:0001101	222	0.027
cellular amino acid metabolic process	GO:0006520	107	0.027
defense response	GO:0006952	194	0.026
regulation of transcription dna templated	GO:0006355	374	0.026
rna biosynthetic process	GO:0032774	380	0.026
negative regulation of neuron death	GO:1901215	69	0.026
positive regulation of multicellular organismal process	GO:0051240	387	0.026
homeostatic process	GO:0042592	331	0.026
intracellular signal transduction	GO:0035556	314	0.026
multicellular organism growth	GO:0035264	1	0.026
regulation of cell migration	GO:0030334	128	0.026
cellular catabolic process	GO:0044248	295	0.026
regulation of secretion by cell	GO:1903530	208	0.026
blood coagulation	GO:0007596	26	0.026
carbohydrate metabolic process	GO:0005975	130	0.026
regulation of response to wounding	GO:1903034	69	0.025
positive regulation of biosynthetic process	GO:0009891	319	0.025
cellular response to oxygen containing compound	GO:1901701	386	0.025
neurological system process	GO:0050877	219	0.025
growth	GO:0040007	165	0.025
secretion	GO:0046903	307	0.024
aromatic compound catabolic process	GO:0019439	168	0.024
regulation of multicellular organismal development	GO:2000026	376	0.024
cellular amide metabolic process	GO:0043603	44	0.024
multi organism reproductive process	GO:0044703	262	0.024
regulation of signal transduction	GO:0009966	318	0.024
tissue regeneration	GO:0042246	36	0.024
response to nutrient levels	GO:0031667	370	0.024
cellular response to lipid	GO:0071396	201	0.023
regulation of cell projection organization	GO:0031344	175	0.023
protein phosphorylation	GO:0006468	345	0.023
cellular response to stress	GO:0033554	269	0.023
regulation of canonical wnt signaling pathway	GO:0060828	4	0.023
regulation of cell proliferation	GO:0042127	359	0.023
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.022
regulation of cellular component organization	GO:0051128	368	0.022
skeletal system development	GO:0001501	41	0.022
negative regulation of cellular protein metabolic process	GO:0032269	106	0.022
regulation of protein modification process	GO:0031399	194	0.022
nucleoside phosphate metabolic process	GO:0006753	283	0.022
regulation of neuron differentiation	GO:0045664	208	0.022
cellular response to endogenous stimulus	GO:0071495	377	0.022
embryonic skeletal system morphogenesis	GO:0048704	3	0.021
protein complex biogenesis	GO:0070271	263	0.021
positive regulation of phosphate metabolic process	GO:0045937	262	0.021
nucleic acid templated transcription	GO:0097659	379	0.021
proteolysis	GO:0006508	175	0.021
purine nucleoside monophosphate catabolic process	GO:0009128	55	0.021
regulation of programmed cell death	GO:0043067	341	0.021
cellular homeostasis	GO:0019725	252	0.020
macromolecular complex assembly	GO:0065003	273	0.020
positive regulation of nervous system development	GO:0051962	178	0.020
protein oligomerization	GO:0051259	191	0.020
single organism reproductive process	GO:0044702	297	0.020
urogenital system development	GO:0001655	78	0.020
gastrulation	GO:0007369	2	0.020
bone development	GO:0060348	25	0.020
response to hypoxia	GO:0001666	231	0.020
regulation of response to external stimulus	GO:0032101	106	0.020
organelle organization	GO:0006996	266	0.019
cofactor metabolic process	GO:0051186	95	0.019
regulation of rna biosynthetic process	GO:2001141	381	0.019
biological adhesion	GO:0022610	110	0.019
ribose phosphate metabolic process	GO:0019693	235	0.019
extracellular structure organization	GO:0043062	13	0.019
protein complex subunit organization	GO:0071822	302	0.019
regulation of inflammatory response	GO:0050727	48	0.018
regulation of protein secretion	GO:0050708	28	0.018
collagen fibril organization	GO:0030199	1	0.018
transcription dna templated	GO:0006351	377	0.018
sulfur compound metabolic process	GO:0006790	70	0.018
protein complex assembly	GO:0006461	263	0.018
nucleotide metabolic process	GO:0009117	279	0.018
positive regulation of cell development	GO:0010720	176	0.018
positive regulation of neurogenesis	GO:0050769	165	0.017
organic substance catabolic process	GO:1901575	316	0.017
positive regulation of programmed cell death	GO:0043068	157	0.017
regulation of neuron projection development	GO:0010975	161	0.017
response to peptide hormone	GO:0043434	278	0.016
positive regulation of protein modification process	GO:0031401	142	0.016
carbohydrate biosynthetic process	GO:0016051	42	0.016
cardiovascular system development	GO:0072358	134	0.016
positive regulation of cell projection organization	GO:0031346	111	0.016
defense response to gram negative bacterium	GO:0050829	3	0.016
nucleoside monophosphate metabolic process	GO:0009123	93	0.016
apoptotic process	GO:0006915	381	0.016
cellular amine metabolic process	GO:0044106	38	0.016
regulation of phosphorylation	GO:0042325	248	0.016
response to external biotic stimulus	GO:0043207	221	0.015
positive regulation of cell differentiation	GO:0045597	217	0.015
immune response	GO:0006955	104	0.015
peptidyl amino acid modification	GO:0018193	126	0.015
cellular cation homeostasis	GO:0030003	180	0.015
purine ribonucleotide biosynthetic process	GO:0009152	81	0.015
positive regulation of response to stimulus	GO:0048584	285	0.015
polysaccharide metabolic process	GO:0005976	25	0.015
behavior	GO:0007610	205	0.015
bmp signaling pathway	GO:0030509	4	0.015
response to cytokine	GO:0034097	215	0.015
organophosphate metabolic process	GO:0019637	370	0.015
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.015
regulation of cellular component movement	GO:0051270	150	0.015
regulation of bmp signaling pathway	GO:0030510	2	0.015
response to inorganic substance	GO:0010035	377	0.015
protein processing	GO:0016485	68	0.015
cell adhesion	GO:0007155	110	0.015
ion transmembrane transport	GO:0034220	365	0.015
transmembrane transport	GO:0055085	412	0.015
catabolic process	GO:0009056	351	0.015
ribonucleoside metabolic process	GO:0009119	174	0.015
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.014
regulation of nucleic acid templated transcription	GO:1903506	380	0.014
reproduction	GO:0000003	245	0.014
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.014
single organism catabolic process	GO:0044712	283	0.014
neuronal action potential	GO:0019228	35	0.014
purine ribonucleotide metabolic process	GO:0009150	227	0.014
dna metabolic process	GO:0006259	96	0.014
positive regulation of secretion	GO:0051047	140	0.014
developmental growth	GO:0048589	100	0.014
cellular polysaccharide metabolic process	GO:0044264	23	0.014
heart morphogenesis	GO:0003007	3	0.014
response to nutrient	GO:0007584	248	0.014
cellular modified amino acid metabolic process	GO:0006575	61	0.013
regulation of cell adhesion	GO:0030155	52	0.013
regulation of peptidase activity	GO:0052547	55	0.013
response to extracellular stimulus	GO:0009991	380	0.013
regulation of membrane potential	GO:0042391	110	0.013
immune effector process	GO:0002252	53	0.013
gamete generation	GO:0007276	124	0.013
regulation of intracellular signal transduction	GO:1902531	218	0.013
connective tissue development	GO:0061448	33	0.013
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.013
regulation of nervous system development	GO:0051960	264	0.013
positive regulation of kinase activity	GO:0033674	77	0.013
regulation of cell motility	GO:2000145	131	0.013
negative regulation of cell communication	GO:0010648	158	0.013
cellular response to topologically incorrect protein	GO:0035967	3	0.013
response to vitamin	GO:0033273	131	0.013
regulation of immune system process	GO:0002682	123	0.013
peptidyl tyrosine phosphorylation	GO:0018108	72	0.013
anatomical structure morphogenesis	GO:0009653	298	0.013
regulation of immune response	GO:0050776	55	0.013
spermatogenesis	GO:0007283	99	0.013
intracellular transport	GO:0046907	185	0.013
body fluid secretion	GO:0007589	41	0.013
single organism carbohydrate metabolic process	GO:0044723	118	0.013
purine containing compound metabolic process	GO:0072521	253	0.013
positive regulation of cell proliferation	GO:0008284	249	0.013
regulation of transferase activity	GO:0051338	123	0.013
signal release	GO:0023061	145	0.013
positive regulation of cell motility	GO:2000147	97	0.013
positive regulation of neuron differentiation	GO:0045666	126	0.012
cation transmembrane transport	GO:0098655	263	0.012
negative regulation of phosphate metabolic process	GO:0045936	80	0.012
response to organophosphorus	GO:0046683	102	0.012
small molecule biosynthetic process	GO:0044283	124	0.012
response to decreased oxygen levels	GO:0036293	237	0.012
organic acid biosynthetic process	GO:0016053	83	0.012
male gamete generation	GO:0048232	99	0.012
circulatory system process	GO:0003013	183	0.012
response to ionizing radiation	GO:0010212	59	0.012
positive regulation of transcription dna templated	GO:0045893	197	0.012
cellular response to organic cyclic compound	GO:0071407	202	0.012
single organism intracellular transport	GO:1902582	166	0.012
mesonephric tubule development	GO:0072164	14	0.012
dephosphorylation	GO:0016311	98	0.012
cellular ion homeostasis	GO:0006873	184	0.012
dendrite morphogenesis	GO:0048813	43	0.012
central nervous system development	GO:0007417	311	0.012
regulation of protein phosphorylation	GO:0001932	183	0.012
regulation of cellular localization	GO:0060341	263	0.012
blood circulation	GO:0008015	183	0.012
cellular component movement	GO:0006928	248	0.012
cellular polysaccharide biosynthetic process	GO:0033692	15	0.012
neuron development	GO:0048666	286	0.011
positive regulation of protein kinase activity	GO:0045860	73	0.011
inorganic ion transmembrane transport	GO:0098660	229	0.011
regulation of anatomical structure size	GO:0090066	135	0.011
positive regulation of rna metabolic process	GO:0051254	203	0.011
positive regulation of cellular component movement	GO:0051272	102	0.011
cell motility	GO:0048870	202	0.011
carboxylic acid biosynthetic process	GO:0046394	83	0.011
regulation of cellular ketone metabolic process	GO:0010565	27	0.011
sexual reproduction	GO:0019953	148	0.011
negative regulation of response to stimulus	GO:0048585	155	0.011
peptidyl lysine hydroxylation	GO:0017185	1	0.011
locomotion	GO:0040011	237	0.011
dendrite development	GO:0016358	72	0.011
regulation of cytokine production	GO:0001817	56	0.011
cyclic nucleotide metabolic process	GO:0009187	80	0.011
circulatory system development	GO:0072359	134	0.011
localization of cell	GO:0051674	202	0.011
negative regulation of apoptotic process	GO:0043066	181	0.011
ribonucleotide metabolic process	GO:0009259	231	0.011
positive regulation of phosphorylation	GO:0042327	177	0.011
reproductive system development	GO:0061458	128	0.011
neuron projection development	GO:0031175	273	0.011
cellular response to growth factor stimulus	GO:0071363	162	0.011
negative regulation of catalytic activity	GO:0043086	103	0.011
positive regulation of ossification	GO:0045778	17	0.011
positive regulation of locomotion	GO:0040017	102	0.011
regulation of blood circulation	GO:1903522	110	0.010
metal ion homeostasis	GO:0055065	186	0.010
regulation of dendrite development	GO:0050773	59	0.010
response to ethanol	GO:0045471	162	0.010
response to toxic substance	GO:0009636	133	0.010
regulation of proteolysis	GO:0030162	66	0.010
organic hydroxy compound metabolic process	GO:1901615	115	0.010
positive regulation of neuron projection development	GO:0010976	99	0.010
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.010
renal system development	GO:0072001	67	0.010
response to bacterium	GO:0009617	200	0.010
response to hexose	GO:0009746	144	0.010
negative regulation of cellular amide metabolic process	GO:0034249	1	0.010
response to ketone	GO:1901654	182	0.010

Ggcx disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.812
musculoskeletal system disease	DOID:17	0.812
connective tissue disease	DOID:65	0.174
bone disease	DOID:0080001	0.174
bone development disease	DOID:0080006	0.087
osteochondrodysplasia	DOID:2256	0.059
inherited metabolic disorder	DOID:655	0.052
disease of metabolism	DOID:0014667	0.052
nervous system disease	DOID:863	0.032
muscular disease	DOID:0080000	0.023
myopathy	DOID:423	0.016
muscle tissue disease	DOID:66	0.016
integumentary system disease	DOID:16	0.014
central nervous system disease	DOID:331	0.010
cardiovascular system disease	DOID:1287	0.010

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