Rattus norvegicus

44 known processes

Eif2ak2

eukaryotic translation initiation factor 2-alpha kinase 2

(Aliases: Pkr,Prkr)

Eif2ak2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of kidney developmentGO:009018520.378
response to biotic stimulusGO:00096072260.285
regulation of mesenchymal cell proliferationGO:001046440.220
rna metabolic processGO:00160704060.216
reproductive processGO:00224143720.210
response to lipopolysaccharideGO:00324961910.197
atp metabolic processGO:0046034720.195
response to external biotic stimulusGO:00432072210.186
response to hydrogen peroxideGO:0042542890.177
positive regulation of mesenchymal cell proliferationGO:000205340.176
response to other organismGO:00517072200.166
negative regulation of metanephros developmentGO:007221720.161
regulation of rna metabolic processGO:00512523910.158
negative regulation of cell deathGO:00605482290.156
mesenchymal to epithelial transitionGO:006023130.146
cellular response to organic cyclic compoundGO:00714072020.138
response to molecule of bacterial originGO:00022371940.136
oxoacid metabolic processGO:00434362900.136
agingGO:00075682410.131
intracellular signal transductionGO:00355563140.126
multicellular organism reproductionGO:00325042330.124
kidney mesenchyme developmentGO:007207420.123
reproductionGO:00000032450.113
ribonucleoside triphosphate metabolic processGO:00091991410.111
gland developmentGO:00487321550.111
response to inorganic substanceGO:00100353770.110
response to reactive oxygen speciesGO:00003021200.107
anatomical structure morphogenesisGO:00096532980.106
regulation of phosphorus metabolic processGO:00511743490.104
regulation of cell developmentGO:00602842630.099
response to peptide hormoneGO:00434342780.095
organic acid metabolic processGO:00060822920.094
cellular response to endogenous stimulusGO:00714953770.092
developmental process involved in reproductionGO:00030061590.092
response to peptideGO:19016522920.092
secretionGO:00469033070.091
ribonucleoside metabolic processGO:00091191740.091
purine nucleoside monophosphate metabolic processGO:0009126840.090
regulation of cellular protein metabolic processGO:00322682670.090
regulation of satellite cell proliferationGO:001484210.090
cellular response to hormone stimulusGO:00328702470.087
negative regulation of gene expressionGO:00106291990.087
defense responseGO:00069521940.086
regulation of transcription dna templatedGO:00063553740.085
organophosphate metabolic processGO:00196373700.079
purine containing compound metabolic processGO:00725212530.079
regulation of nucleic acid templated transcriptionGO:19035063800.078
cellular response to reactive oxygen speciesGO:0034614550.077
reproductive system developmentGO:00614581280.076
response to oxidative stressGO:00069791860.075
regulation of cell morphogenesis involved in differentiationGO:0010769720.075
ribonucleotide metabolic processGO:00092592310.074
tissue developmentGO:00098882520.074
response to estradiolGO:00323551640.071
epithelial cell differentiation involved in kidney developmentGO:003585030.070
mesenchymal cell proliferationGO:001046340.070
cellular component movementGO:00069282480.067
regulation of atp biosynthetic processGO:200116920.067
response to oxygen levelsGO:00704822650.067
hepaticobiliary system developmentGO:0061008900.067
response to cytokineGO:00340972150.066
metanephric nephron tubule epithelial cell differentiationGO:007225710.065
response to ethanolGO:00454711620.065
regulation of multicellular organismal developmentGO:20000263760.064
cellular response to oxidative stressGO:0034599760.063
tube developmentGO:0035295890.063
response to growth factorGO:00708481890.063
response to decreased oxygen levelsGO:00362932370.063
nucleotide metabolic processGO:00091172790.063
negative regulation of nucleic acid templated transcriptionGO:19035071170.062
negative regulation of multicellular organismal processGO:00512412030.061
positive regulation of nitrogen compound metabolic processGO:00511733340.061
regulation of protein modification processGO:00313991940.061
cellular amino acid metabolic processGO:00065201070.060
transcription dna templatedGO:00063513770.059
purine ribonucleoside triphosphate metabolic processGO:00092051400.059
cellular ketone metabolic processGO:0042180510.059
regulation of reactive oxygen species metabolic processGO:2000377260.059
head developmentGO:00603222470.058
response to hypoxiaGO:00016662310.058
neuron deathGO:00709971270.057
mesenchymal cell differentiation involved in renal system developmentGO:200101210.057
regulation of rna biosynthetic processGO:20011413810.057
nucleoside phosphate metabolic processGO:00067532830.056
single organism reproductive processGO:00447022970.055
cellular component biogenesisGO:00440853680.055
carboxylic acid metabolic processGO:00197522890.054
cellular response to lipidGO:00713962010.054
protein phosphorylationGO:00064683450.054
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:000334020.054
nephron tubule epithelial cell differentiationGO:007216010.054
cellular response to peptide hormone stimulusGO:00713751200.054
cell morphogenesis involved in differentiationGO:00009041190.053
central nervous system developmentGO:00074173110.052
apoptotic processGO:00069153810.052
positive regulation of phosphorus metabolic processGO:00105622620.051
blood circulationGO:00080151830.050
catabolic processGO:00090563510.050
response to purine containing compoundGO:00140741260.050
nucleoside monophosphate metabolic processGO:0009123930.049
response to mechanical stimulusGO:00096121340.049
cellular response to organonitrogen compoundGO:00714171970.049
single organism biosynthetic processGO:00447113420.048
circulatory system processGO:00030131830.048
regulation of phosphate metabolic processGO:00192203490.048
rhythmic processGO:00485111560.047
regulation of phosphorylationGO:00423252480.047
regulation of molecular functionGO:00650093980.047
reproductive structure developmentGO:00486081280.047
nucleoside phosphate biosynthetic processGO:19012931020.046
regulation of cell differentiationGO:00455953200.046
positive regulation of cell proliferationGO:00082842490.045
positive regulation of phosphate metabolic processGO:00459372620.045
negative regulation of metabolic processGO:00098923310.045
regulation of epithelial cell differentiationGO:0030856120.045
positive regulation of nucleobase containing compound metabolic processGO:00459353190.044
purine containing compound biosynthetic processGO:0072522850.044
response to acid chemicalGO:00011012220.044
regulation of cellular component organizationGO:00511283680.044
jak stat cascadeGO:0007259260.044
negative regulation of neuron deathGO:1901215690.043
positive regulation of growth factor dependent skeletal muscle satellite cell proliferationGO:190272810.043
positive regulation of biosynthetic processGO:00098913190.043
reactive oxygen species metabolic processGO:0072593370.042
liver developmentGO:0001889900.042
glycosyl compound metabolic processGO:19016571820.042
skeletal muscle satellite cell proliferationGO:001484110.042
cellular response to growth factor stimulusGO:00713631620.041
regulation of protein metabolic processGO:00512462890.041
gonad developmentGO:00084061040.041
mesenchymal cell differentiation involved in kidney developmentGO:007216110.041
response to bacteriumGO:00096172000.040
cellular component morphogenesisGO:00329891550.040
cell differentiation involved in kidney developmentGO:006100540.039
purine ribonucleotide metabolic processGO:00091502270.039
ribonucleoside monophosphate metabolic processGO:0009161880.039
regulation of body fluid levelsGO:0050878900.039
negative regulation of macromolecule metabolic processGO:00106052600.039
metal ion transportGO:00300012890.038
development of primary sexual characteristicsGO:00451371070.038
development of primary female sexual characteristicsGO:0046545560.038
regulation of cell proliferationGO:00421273590.038
cellular response to cytokine stimulusGO:00713451270.038
response to metal ionGO:00100382530.037
regulation of cellular amine metabolic processGO:003323880.037
amine metabolic processGO:0009308380.037
organonitrogen compound biosynthetic processGO:19015661670.037
homeostatic processGO:00425923310.037
programmed cell deathGO:00125013920.037
proteolysisGO:00065081750.037
regulation of cellular ketone metabolic processGO:0010565270.037
positive regulation of cellular biosynthetic processGO:00313282950.037
positive regulation of response to stimulusGO:00485842850.037
female gonad developmentGO:0008585530.037
secretion by tissueGO:0032941370.037
cellular amine metabolic processGO:0044106380.036
carbohydrate derivative metabolic processGO:19011353460.036
cellular response to insulin stimulusGO:0032869810.036
positive regulation of multicellular organismal processGO:00512403870.035
female sex differentiationGO:0046660590.035
ribonucleotide biosynthetic processGO:0009260850.035
ribose phosphate biosynthetic processGO:0046390870.035
cell proliferation involved in metanephros developmentGO:007220320.035
sex differentiationGO:00075481130.034
multicellular organismal reproductive processGO:00486092330.034
purine ribonucleoside monophosphate metabolic processGO:0009167840.034
metanephric mesenchymal cell differentiationGO:007216210.034
regulation of metanephros developmentGO:007221540.034
ovulation cycleGO:0042698670.033
cellular response to stressGO:00335542690.033
ribose phosphate metabolic processGO:00196932350.033
regulation of transcription from rna polymerase ii promoterGO:00063572340.033
brain developmentGO:00074202470.033
regulation of cellular amino acid metabolic processGO:000652120.033
cell type specific apoptotic processGO:00972851340.032
cation homeostasisGO:00550801950.031
regulation of nephron tubule epithelial cell differentiationGO:007218210.031
neuron projection developmentGO:00311752730.031
nucleoside metabolic processGO:00091161790.031
response to nutrientGO:00075842480.031
response to campGO:0051591910.031
response to estrogenGO:00436272320.031
kidney mesenchymal cell proliferationGO:007213510.030
cellular response to peptideGO:19016531330.030
regulation of apoptotic processGO:00429813350.030
cellular response to oxygen containing compoundGO:19017013860.030
tyrosine phosphorylation of stat1 proteinGO:004250830.029
cellular catabolic processGO:00442482950.029
positive regulation of interleukin 1 beta secretionGO:005071830.029
multi organism reproductive processGO:00447032620.029
purine nucleotide metabolic processGO:00061632290.029
regulation of cellular component movementGO:00512701500.029
response to nutrient levelsGO:00316673700.028
nucleobase containing small molecule metabolic processGO:00550863160.028
metanephric renal vesicle morphogenesisGO:007228330.028
response to woundingGO:00096112540.028
regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:000333920.028
regulation of epithelial cell differentiation involved in kidney developmentGO:200069610.028
metanephric mesenchyme developmentGO:007207520.028
cellular response to nitrogen compoundGO:19016992100.028
secretion by cellGO:00329402480.028
metanephric mesenchymal cell proliferation involved in metanephros developmentGO:007213610.028
purine nucleoside metabolic processGO:00422781690.027
membrane organizationGO:0061024940.027
muscle cell proliferationGO:0033002840.027
response to carbohydrateGO:00097431830.027
negative regulation of cellular metabolic processGO:00313242810.026
response to extracellular stimulusGO:00099913800.026
ovulation cycle processGO:0022602500.026
single organism intracellular transportGO:19025821660.026
g protein coupled receptor signaling pathwayGO:00071862420.026
regulation of anatomical structure morphogenesisGO:00226031410.026
purine ribonucleotide biosynthetic processGO:0009152810.026
neuron differentiationGO:00301823680.026
regulation of signal transductionGO:00099663180.025
rna biosynthetic processGO:00327743800.025
regulation of programmed cell deathGO:00430673410.025
positive regulation of gene expressionGO:00106282440.025
mammary gland involutionGO:006005650.025
positive regulation of nucleotide biosynthetic processGO:0030810360.025
cell morphogenesisGO:00009021420.025
cellular homeostasisGO:00197252520.025
regulation of nucleotide biosynthetic processGO:0030808470.025
protein complex assemblyGO:00064612630.024
morphogenesis of an epitheliumGO:0002009200.024
cation transportGO:00068123820.024
response to monosaccharideGO:00342841590.024
regulation of skeletal muscle cell proliferationGO:001485720.024
positive regulation of protein metabolic processGO:00512471780.024
epithelium developmentGO:0060429960.024
nucleoside triphosphate metabolic processGO:00091411440.024
nucleic acid templated transcriptionGO:00976593790.024
metal ion homeostasisGO:00550651860.024
inflammatory responseGO:00069541500.024
smooth muscle cell proliferationGO:0048659770.024
behaviorGO:00076102050.024
negative regulation of cell communicationGO:00106481580.024
negative regulation of biosynthetic processGO:00098901680.024
cellular component assemblyGO:00226073600.023
positive regulation of skeletal muscle cell proliferationGO:001485820.023
response to organophosphorusGO:00466831020.023
negative regulation of cellular biosynthetic processGO:00313271610.023
negative regulation of macromolecule biosynthetic processGO:00105581480.023
positive regulation of phosphorylationGO:00423271770.023
transmembrane transportGO:00550854120.023
ion homeostasisGO:00508012120.023
axis specificationGO:000979840.023
macromolecular complex assemblyGO:00650032730.023
purine ribonucleoside metabolic processGO:00461281680.023
purine nucleotide biosynthetic processGO:0006164830.022
purine nucleoside biosynthetic processGO:0042451210.022
negative regulation of nitrogen compound metabolic processGO:00511721610.022
positive regulation of stem cell proliferationGO:2000648130.022
mammary gland morphogenesisGO:006044360.022
renal vesicle morphogenesisGO:007207740.022
reactive oxygen species biosynthetic processGO:190340980.022
metanephros morphogenesisGO:000333860.022
positive regulation of programmed cell deathGO:00430681570.022
regulation of purine nucleotide metabolic processGO:19005421150.022
positive regulation of satellite cell proliferationGO:190272410.022
positive regulation of nucleic acid templated transcriptionGO:19035081970.022
atp catabolic processGO:0006200540.022
purine nucleoside monophosphate biosynthetic processGO:0009127200.021
regulation of catalytic activityGO:00507903040.021
positive regulation of cellular amino acid metabolic processGO:004576410.021
locomotionGO:00400112370.021
positive regulation of signal transductionGO:00099671750.021
protein oligomerizationGO:00512591910.021
regulation of protein phosphorylationGO:00019321830.021
organ morphogenesisGO:0009887750.021
urogenital system developmentGO:0001655780.021
peptidyl tyrosine modificationGO:0018212720.021
transcription from rna polymerase ii promoterGO:00063662520.021
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.020
positive regulation of cellular protein metabolic processGO:00322701670.020
response to radiationGO:00093141370.020
positive regulation of transportGO:00510502450.020
tissue morphogenesisGO:0048729220.020
protein complex biogenesisGO:00702712630.020
cell differentiation involved in metanephros developmentGO:007220210.020
single organism carbohydrate catabolic processGO:0044724400.020
positive regulation of macromolecule biosynthetic processGO:00105572470.020
immune responseGO:00069551040.020
negative regulation of metanephric nephron tubule epithelial cell differentiationGO:007230810.020
neurological system processGO:00508772190.020
regulation of hydrogen peroxide biosynthetic processGO:001072820.019
organelle organizationGO:00069962660.019
positive regulation of transcription dna templatedGO:00458931970.019
renal system developmentGO:0072001670.019
response to corticosteroidGO:00319602350.019
positive regulation of molecular functionGO:00440932300.019
nucleotide biosynthetic processGO:0009165980.019
cellular chemical homeostasisGO:00550822470.019
cell cell signalingGO:00072673350.019
positive regulation of signalingGO:00230562700.019
positive regulation of purine nucleotide metabolic processGO:1900544910.019
organophosphate biosynthetic processGO:00904071430.019
regulation of hydrolase activityGO:00513361430.019
negative regulation of programmed cell deathGO:00430691830.019
synaptic growth at neuromuscular junctionGO:005112410.019
regulation of nucleotide metabolic processGO:00061401170.019
regulation of reactive oxygen species biosynthetic processGO:190342650.019
chemical homeostasisGO:00488782920.018
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.018
organic substance catabolic processGO:19015753160.018
positive regulation of intracellular signal transductionGO:19025331380.018
positive regulation of cell differentiationGO:00455972170.018
acute inflammatory responseGO:0002526580.018
positive regulation of nucleoside metabolic processGO:0045979550.018
intracellular transportGO:00469071850.018
neuron developmentGO:00486662860.018
positive regulation of cell deathGO:00109421840.018
regulation of nervous system developmentGO:00519602640.018
negative regulation of transcription dna templatedGO:00458921160.018
response to glucoseGO:00097491360.018
positive regulation of rna biosynthetic processGO:19026801970.018
negative regulation of organ growthGO:004662130.018
negative regulation of developmental processGO:00510931250.018
positive regulation of cell developmentGO:00107201760.017
positive regulation of atp biosynthetic processGO:200117120.017
regulation of response to stressGO:00801341260.017
negative regulation of cell developmentGO:0010721820.017
female pregnancyGO:00075651220.017
macromolecule localizationGO:00330362520.017
organonitrogen compound catabolic processGO:19015651790.017
metanephric nephron epithelium developmentGO:007224330.017
response to transition metal nanoparticleGO:19902671220.017
organic cyclic compound catabolic processGO:19013611750.017
metanephric tubule developmentGO:007217040.017
negative regulation of viral processGO:004852540.017
regulation of metanephric nephron tubule epithelial cell differentiationGO:007230710.017
metanephric epithelium developmentGO:007220740.017
positive regulation of smooth muscle cell proliferationGO:0048661510.017
positive regulation of protein phosphorylationGO:00019341350.016
mammary gland developmentGO:0030879380.016
response to hexoseGO:00097461440.016
cellular response to acid chemicalGO:0071229750.016
negative regulation of signalingGO:00230571570.016
protein complex subunit organizationGO:00718223020.016
regulation of purine nucleotide biosynthetic processGO:1900371460.016
positive regulation of catalytic activityGO:00430851840.016
ion transmembrane transportGO:00342203650.016
kidney morphogenesisGO:0060993130.016
negative regulation of cell differentiationGO:0045596990.016
forebrain developmentGO:0030900980.016
single organism catabolic processGO:00447122830.016
purine ribonucleoside biosynthetic processGO:0046129210.016
cellular ion homeostasisGO:00068731840.016
regulation of stem cell proliferationGO:0072091140.016
cellular cation homeostasisGO:00300031800.016
cytokine mediated signaling pathwayGO:0019221430.016
positive regulation of cellular amine metabolic processGO:003324030.016
signal transduction by phosphorylationGO:00230141440.015
gamete generationGO:00072761240.015
positive regulation of nucleotide metabolic processGO:0045981910.015
sensory organ developmentGO:0007423740.015
regulation of cell migrationGO:00303341280.015
cellular response to hydrogen peroxideGO:0070301420.015
response to insulinGO:00328681330.015
multi multicellular organism processGO:00447061380.015
cell projection organizationGO:00300303020.015
purine nucleoside triphosphate metabolic processGO:00091441410.015
peptidyl amino acid modificationGO:00181931260.015
negative regulation of hydrogen peroxide biosynthetic processGO:001073020.015
negative regulation of reactive oxygen species metabolic processGO:200037870.015
action potentialGO:0001508540.015
cellular metal ion homeostasisGO:00068751720.015
response to dsrnaGO:004333190.015
negative regulation of protein metabolic processGO:00512481140.015
regulation of system processGO:00440572080.015
regulation of cell morphogenesisGO:0022604770.014
response to glucocorticoidGO:00513842230.014
neuron apoptotic processGO:0051402880.014
regulation of locomotionGO:00400121480.014
negative regulation of hydrogen peroxide metabolic processGO:001072720.014
positive regulation of developmental processGO:00510942830.014
purine ribonucleoside monophosphate biosynthetic processGO:0009168200.014
positive regulation of cellular component movementGO:00512721020.014
cellular response to external stimulusGO:00714961180.014
positive regulation of apoptotic processGO:00430651540.014
cardiac chamber developmentGO:000320510.014
developmental growthGO:00485891000.014
divalent inorganic cation homeostasisGO:00725071650.014
cellular response to nutrient levelsGO:0031669600.014
regulation of secretion by cellGO:19035302080.013
negative regulation of rna biosynthetic processGO:19026791180.013
kidney developmentGO:0001822670.013
positive regulation of purine nucleotide biosynthetic processGO:1900373360.013
mitochondrion organizationGO:0007005350.013
negative regulation of rna metabolic processGO:00512531230.013
regulation of cellular localizationGO:00603412630.013
muscle structure developmentGO:0061061870.013
protein maturationGO:0051604680.013
eye morphogenesisGO:004859240.013
positive regulation of cell communicationGO:00106472710.013
regulation of blood circulationGO:19035221100.013
b cell activation involved in immune responseGO:000231210.013
negative regulation of cellular protein metabolic processGO:00322691060.013
sexual reproductionGO:00199531480.012
regulation of membrane potentialGO:00423911100.012
regulation of hormone levelsGO:00108171870.012
positive regulation of secretion by cellGO:19035321280.012
calcium ion transportGO:00068161310.012
regulation of cell cycleGO:0051726730.012
positive regulation of rna metabolic processGO:00512542030.012
divalent inorganic cation transportGO:00725111340.012
inorganic ion transmembrane transportGO:00986602290.012
circadian rhythmGO:0007623880.012
rna localizationGO:000640340.012
multicellular organismal signalingGO:0035637440.012
positive regulation of protein modification processGO:00314011420.012
body fluid secretionGO:0007589410.012
cellular divalent inorganic cation homeostasisGO:00725031620.012
cellular response to lipopolysaccharideGO:0071222550.012
single organism organelle organizationGO:19025891800.011
positive regulation of locomotionGO:00400171020.011
negative regulation of response to stimulusGO:00485851550.011
regulation of neurogenesisGO:00507672470.011
response to alkaloidGO:00432791320.011
morphogenesis of embryonic epitheliumGO:001633130.011
cellular response to molecule of bacterial originGO:0071219560.011
negative regulation of apoptotic processGO:00430661810.011
negative regulation of nucleobase containing compound metabolic processGO:00459341530.011
negative regulation of molecular functionGO:00440921330.011
regulation of synaptic growth at neuromuscular junctionGO:000858210.011
nitrogen compound transportGO:00717052290.011
calcium ion homeostasisGO:00550741620.011
regulation of neuron projection developmentGO:00109751610.011
protein localizationGO:00081041910.011
regulation of cell projection organizationGO:00313441750.011
tolerance induction to nonself antigenGO:000246220.011
response to amino acidGO:0043200750.011
positive regulation of nervous system developmentGO:00519621780.010
regulation of mapk cascadeGO:00434081160.010
cellular response to abiotic stimulusGO:0071214850.010
regulation of homeostatic processGO:00328441010.010
wound healingGO:00420601220.010
epithelial tube formationGO:007217530.010
positive regulation of interleukin 1 secretionGO:005071630.010
tube formationGO:003514830.010
regulation of canonical wnt signaling pathwayGO:006082840.010
mesenchyme developmentGO:006048590.010
spermatogenesisGO:0007283990.010

Eif2ak2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.013
urinary system diseaseDOID:1800.013