IMP: Integrative Multi-species Prediction

Rattus norvegicus

9 known processes

Col6a2

collagen, type VI, alpha 2

Entrez: 361821
Ensembl: ENSRNOG00000001254
RGD: 1305585
UniProtKB: Q5EB88
UniProtKB: F1LNH3

Process Predictions
Disease Predictions

Col6a2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to fluoride	GO:1902617	3	0.443
response to growth factor	GO:0070848	189	0.173
cartilage development involved in endochondral bone morphogenesis	GO:0060351	3	0.169
embryonic skeletal system development	GO:0048706	3	0.107
cellular response to growth factor stimulus	GO:0071363	162	0.105
macromolecular complex subunit organization	GO:0043933	339	0.098	Human
response to corticosteroid	GO:0031960	235	0.097
response to ionizing radiation	GO:0010212	59	0.086
response to estradiol	GO:0032355	164	0.084
cellular response to vitamin e	GO:0071306	3	0.083
endochondral bone morphogenesis	GO:0060350	7	0.077
extracellular fibril organization	GO:0043206	1	0.070
peptide cross linking	GO:0018149	1	0.069
response to camp	GO:0051591	91	0.067
collagen fibril organization	GO:0030199	1	0.065
single organism biosynthetic process	GO:0044711	342	0.063
response to purine containing compound	GO:0014074	126	0.061
response to mechanical stimulus	GO:0009612	134	0.056
positive regulation of gene expression	GO:0010628	244	0.056
response to interleukin 2	GO:0070669	1	0.053
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.050
response to cytokine	GO:0034097	215	0.047
muscle structure development	GO:0061061	87	0.045
transforming growth factor beta receptor signaling pathway	GO:0007179	18	0.044
response to nutrient	GO:0007584	248	0.044
macromolecular complex assembly	GO:0065003	273	0.043	Human
response to nutrient levels	GO:0031667	370	0.042
protein heterotrimerization	GO:0070208	2	0.040	Human
growth plate cartilage development	GO:0003417	2	0.040
tooth eruption	GO:0044691	1	0.040
response to wounding	GO:0009611	254	0.039
cellular component assembly	GO:0022607	360	0.039	Human
cellular response to hormone stimulus	GO:0032870	247	0.038
multi multicellular organism process	GO:0044706	138	0.038
regulation of multicellular organismal development	GO:2000026	376	0.038
response to extracellular stimulus	GO:0009991	380	0.038
endochondral ossification	GO:0001958	2	0.038
protein heterooligomerization	GO:0051291	89	0.037	Human
cellular amine metabolic process	GO:0044106	38	0.037
odontogenesis	GO:0042476	32	0.034
bone development	GO:0060348	25	0.034
cellular response to abiotic stimulus	GO:0071214	85	0.034
response to oxygen levels	GO:0070482	265	0.034
response to acid chemical	GO:0001101	222	0.033
muscle organ development	GO:0007517	50	0.032
response to organophosphorus	GO:0046683	102	0.031
reproductive process	GO:0022414	372	0.031
growth	GO:0040007	165	0.030
cellular response to organic cyclic compound	GO:0071407	202	0.030
cellular response to nicotine	GO:0071316	7	0.030
response to glucocorticoid	GO:0051384	223	0.029
cartilage development	GO:0051216	22	0.029
protein oligomerization	GO:0051259	191	0.029	Human
cellular response to interleukin 2	GO:0071352	1	0.028
female pregnancy	GO:0007565	122	0.028
muscle tissue development	GO:0060537	58	0.028
tissue development	GO:0009888	252	0.028
protein complex assembly	GO:0006461	263	0.027	Human
cellular response to lipid	GO:0071396	201	0.027
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.027
protein complex subunit organization	GO:0071822	302	0.027	Human
response to hyperoxia	GO:0055093	45	0.027
rna biosynthetic process	GO:0032774	380	0.026
response to vitamin	GO:0033273	131	0.026
carboxylic acid metabolic process	GO:0019752	289	0.026
cellular response to transforming growth factor beta stimulus	GO:0071560	41	0.025
urogenital system development	GO:0001655	78	0.025
cation homeostasis	GO:0055080	195	0.025
artery development	GO:0060840	3	0.024
connective tissue development	GO:0061448	33	0.024
cellular response to mechanical stimulus	GO:0071260	48	0.023
chemical homeostasis	GO:0048878	292	0.023
skeletal system morphogenesis	GO:0048705	12	0.023
regulation of protein metabolic process	GO:0051246	289	0.023
response to other organism	GO:0051707	220	0.023
ossification	GO:0001503	70	0.023
regulation of cellular protein metabolic process	GO:0032268	267	0.023
regeneration	GO:0031099	163	0.023
cellular response to metal ion	GO:0071248	55	0.022
cellular response to external stimulus	GO:0071496	118	0.022
response to inorganic substance	GO:0010035	377	0.022
response to transforming growth factor beta	GO:0071559	46	0.021
regulation of cell motility	GO:2000145	131	0.021
cellular response to glucocorticoid stimulus	GO:0071385	68	0.020
regulation of rna metabolic process	GO:0051252	391	0.020
kidney development	GO:0001822	67	0.020
ras protein signal transduction	GO:0007265	29	0.020
response to radiation	GO:0009314	137	0.020
multi organism reproductive process	GO:0044703	262	0.020
cellular response to cytokine stimulus	GO:0071345	127	0.020
positive regulation of endothelial cell migration	GO:0010595	4	0.019
positive regulation of stem cell differentiation	GO:2000738	2	0.019
response to increased oxygen levels	GO:0036296	45	0.019
rna metabolic process	GO:0016070	406	0.019
cellular response to nutrient	GO:0031670	30	0.019
multicellular organism reproduction	GO:0032504	233	0.019
extracellular matrix organization	GO:0030198	13	0.019
response to catecholamine	GO:0071869	16	0.018
metal ion homeostasis	GO:0055065	186	0.018
lipid metabolic process	GO:0006629	283	0.018
skeletal system development	GO:0001501	41	0.018
renal system development	GO:0072001	67	0.018
positive regulation of rna metabolic process	GO:0051254	203	0.018
head development	GO:0060322	247	0.017
cellular response to tumor necrosis factor	GO:0071356	46	0.017
secretion by cell	GO:0032940	248	0.017
cellular response to acid chemical	GO:0071229	75	0.017
regulation of rna biosynthetic process	GO:2001141	381	0.017
response to peptide	GO:1901652	292	0.017
cellular response to organonitrogen compound	GO:0071417	197	0.017
proteolysis	GO:0006508	175	0.017
wound healing	GO:0042060	122	0.016
regulation of ossification	GO:0030278	32	0.016
epithelial cell differentiation	GO:0030855	71	0.016
epithelium development	GO:0060429	96	0.016
positive regulation of developmental process	GO:0051094	283	0.016
cellular response to oxygen containing compound	GO:1901701	386	0.016
defense response	GO:0006952	194	0.016
regulation of nucleic acid templated transcription	GO:1903506	380	0.016
regulation of epithelial to mesenchymal transition	GO:0010717	2	0.016
regulation of canonical wnt signaling pathway	GO:0060828	4	0.015
cellular response to peptide hormone stimulus	GO:0071375	120	0.015
protein homooligomerization	GO:0051260	91	0.015
skin morphogenesis	GO:0043589	2	0.015
response to monosaccharide	GO:0034284	159	0.015
striated muscle tissue development	GO:0014706	58	0.015
cellular homeostasis	GO:0019725	252	0.015
muscle tissue morphogenesis	GO:0060415	1	0.015
organic acid metabolic process	GO:0006082	292	0.015
positive regulation of cellular biosynthetic process	GO:0031328	295	0.015
negative regulation of cellular metabolic process	GO:0031324	281	0.014
response to activity	GO:0014823	73	0.014
cellular amino acid metabolic process	GO:0006520	107	0.014
single organism reproductive process	GO:0044702	297	0.014
negative regulation of catalytic activity	GO:0043086	103	0.014
cellular ion homeostasis	GO:0006873	184	0.014
negative regulation of rna metabolic process	GO:0051253	123	0.014
defense response to gram negative bacterium	GO:0050829	3	0.014
oxoacid metabolic process	GO:0043436	290	0.014
cellular response to nitrogen compound	GO:1901699	210	0.014
cellular component biogenesis	GO:0044085	368	0.014	Human
cellular response to nutrient levels	GO:0031669	60	0.014
response to ketone	GO:1901654	182	0.014
aging	GO:0007568	241	0.013
response to estrogen	GO:0043627	232	0.013
cellular chemical homeostasis	GO:0055082	247	0.013
embryo implantation	GO:0007566	15	0.013
divalent inorganic cation homeostasis	GO:0072507	165	0.013
regulation of immune response	GO:0050776	55	0.013
negative regulation of macromolecule metabolic process	GO:0010605	260	0.013
response to retinoic acid	GO:0032526	63	0.013
cellular response to peptide	GO:1901653	133	0.013
response to external biotic stimulus	GO:0043207	221	0.013
amine metabolic process	GO:0009308	38	0.013
reproduction	GO:0000003	245	0.013
cellular response to extracellular stimulus	GO:0031668	73	0.013
regulation of signal transduction	GO:0009966	318	0.013
positive regulation of cellular amine metabolic process	GO:0033240	3	0.013
osteoblast differentiation	GO:0001649	26	0.013
transcription dna templated	GO:0006351	377	0.013
response to vitamin e	GO:0033197	24	0.012
protein complex biogenesis	GO:0070271	263	0.012	Human
transmembrane transport	GO:0055085	412	0.012
negative regulation of metabolic process	GO:0009892	331	0.012
positive regulation of biosynthetic process	GO:0009891	319	0.012
regulation of cellular ketone metabolic process	GO:0010565	27	0.012
response to oxidative stress	GO:0006979	186	0.012
cellular response to fluoride	GO:1902618	1	0.011
response to tumor necrosis factor	GO:0034612	56	0.011
regulation of nervous system development	GO:0051960	264	0.011
camera type eye morphogenesis	GO:0048593	2	0.011
regulation of cellular amine metabolic process	GO:0033238	8	0.011
cellular component movement	GO:0006928	248	0.011
cellular ketone metabolic process	GO:0042180	51	0.011
regulation of cell differentiation	GO:0045595	320	0.011
regulation of stem cell differentiation	GO:2000736	2	0.011
negative regulation of gene expression	GO:0010629	199	0.011
appendage morphogenesis	GO:0035107	4	0.011
central nervous system development	GO:0007417	311	0.011
positive regulation of rna biosynthetic process	GO:1902680	197	0.010
cellular response to endogenous stimulus	GO:0071495	377	0.010
regulation of cell development	GO:0060284	263	0.010
positive regulation of response to stimulus	GO:0048584	285	0.010
response to peptide hormone	GO:0043434	278	0.010
developmental growth	GO:0048589	100	0.010
cellular response to vitamin	GO:0071295	21	0.010
circulatory system development	GO:0072359	134	0.010
regulation of embryonic development	GO:0045995	2	0.010
cellular metal ion homeostasis	GO:0006875	172	0.010
homeostatic process	GO:0042592	331	0.010
endochondral bone growth	GO:0003416	3	0.010

Col6a2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.350	Human
connective tissue disease	DOID:65	0.350
musculoskeletal system disease	DOID:17	0.350	Human
bone disease	DOID:0080001	0.350
bone development disease	DOID:0080006	0.175
muscular disease	DOID:0080000	0.045	Human
muscular dystrophy	DOID:9884	0.045	Human
myopathy	DOID:423	0.045	Human
muscle tissue disease	DOID:66	0.045	Human
osteochondrodysplasia	DOID:2256	0.042
nervous system disease	DOID:863	0.019
ehlers danlos syndrome	DOID:13359	0.015
collagen disease	DOID:854	0.015
central nervous system disease	DOID:331	0.010

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