Rattus norvegicus

0 known processes

Fam38b

family with sequence similarity 38, member B

(Aliases: RGD1306866)

Fam38b biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to peptide hormoneGO:00434342780.669
cytosolic calcium ion homeostasisGO:00514801400.354
cellular chemical homeostasisGO:00550822470.343
cellular metal ion homeostasisGO:00068751720.312
regulation of cell proliferationGO:00421273590.308
positive regulation of multicellular organismal processGO:00512403870.263
response to estrogenGO:00436272320.253
cation transportGO:00068123820.231
positive regulation of cytosolic calcium ion concentrationGO:00072041220.230
positive regulation of gene expressionGO:00106282440.219
secretionGO:00469033070.213
positive regulation of biosynthetic processGO:00098913190.198
lipid localizationGO:0010876620.191
cellular homeostasisGO:00197252520.190
regulation of phosphate metabolic processGO:00192203490.161
response to temperature stimulusGO:0009266940.158
localization of cellGO:00516742020.157
rna metabolic processGO:00160704060.155
cellular response to endogenous stimulusGO:00714953770.152
synaptic transmissionGO:00072682350.151
mapk cascadeGO:00001651400.147
cellular calcium ion homeostasisGO:00068741600.141
regulation of intracellular signal transductionGO:19025312180.139
cellular divalent inorganic cation homeostasisGO:00725031620.136
positive regulation of nitrogen compound metabolic processGO:00511733340.135
negative regulation of metabolic processGO:00098923310.134
response to ethanolGO:00454711620.132
head developmentGO:00603222470.131
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.128
homeostatic processGO:00425923310.125
response to peptideGO:19016522920.125
intracellular signal transductionGO:00355563140.124
programmed cell deathGO:00125013920.121
transmembrane transportGO:00550854120.121
multi organism reproductive processGO:00447032620.120
positive regulation of cell proliferationGO:00082842490.119
cell cell signalingGO:00072673350.116
negative regulation of gene expressionGO:00106291990.115
hormone transportGO:00099141210.114
signal transduction by phosphorylationGO:00230141440.113
positive regulation of developmental processGO:00510942830.111
positive regulation of cellular biosynthetic processGO:00313282950.109
positive regulation of macromolecule biosynthetic processGO:00105572470.109
calcium ion homeostasisGO:00550741620.108
anion transportGO:00068201780.106
immune system processGO:00023762040.106
phasic smooth muscle contractionGO:001482130.105
regulation of hormone secretionGO:00468831060.105
brain developmentGO:00074202470.103
apoptotic processGO:00069153810.102
nucleic acid templated transcriptionGO:00976593790.102
regulation of transcription dna templatedGO:00063553740.101
positive regulation of nucleic acid templated transcriptionGO:19035081970.099
positive regulation of nucleobase containing compound metabolic processGO:00459353190.096
transcription dna templatedGO:00063513770.094
regulation of hormone levelsGO:00108171870.093
regulation of secretion by cellGO:19035302080.093
ion homeostasisGO:00508012120.092
negative regulation of apoptotic processGO:00430661810.092
negative regulation of rna biosynthetic processGO:19026791180.091
cellular ketone metabolic processGO:0042180510.090
response to estradiolGO:00323551640.089
positive regulation of transcription dna templatedGO:00458931970.088
rna biosynthetic processGO:00327743800.088
regulation of rna metabolic processGO:00512523910.087
neurological system processGO:00508772190.086
divalent inorganic cation homeostasisGO:00725071650.086
biological adhesionGO:00226101100.086
cellular component movementGO:00069282480.083
regulation of nucleic acid templated transcriptionGO:19035063800.083
development of primary female sexual characteristicsGO:0046545560.083
regulation of ion transportGO:00432692450.083
cellular ion homeostasisGO:00068731840.083
ossificationGO:0001503700.082
response to carbohydrateGO:00097431830.082
response to heatGO:0009408600.081
regulation of transcription from rna polymerase ii promoterGO:00063572340.079
cellular response to organic cyclic compoundGO:00714072020.078
metal ion homeostasisGO:00550651860.076
alcohol metabolic processGO:0006066770.076
regulation of signal transductionGO:00099663180.075
negative regulation of cellular metabolic processGO:00313242810.075
regulation of protein metabolic processGO:00512462890.074
cellular response to hormone stimulusGO:00328702470.074
positive regulation of phosphate metabolic processGO:00459372620.074
cation homeostasisGO:00550801950.074
hormone secretionGO:00468791150.072
single organism reproductive processGO:00447022970.072
saliva secretionGO:004654130.071
response to corticosteroidGO:00319602350.071
positive regulation of phosphorylationGO:00423271770.070
negative regulation of nitrogen compound metabolic processGO:00511721610.070
regulation of mapk cascadeGO:00434081160.070
positive regulation of ion transportGO:0043270940.070
central nervous system developmentGO:00074173110.070
cellular response to peptideGO:19016531330.070
regulation of apoptotic processGO:00429813350.070
amine metabolic processGO:0009308380.070
divalent metal ion transportGO:00708381320.069
response to hexoseGO:00097461440.069
tissue developmentGO:00098882520.069
response to alkaloidGO:00432791320.068
cellular response to nitrogen compoundGO:19016992100.068
cell motilityGO:00488702020.068
cellular response to lipidGO:00713962010.067
peptidyl tyrosine phosphorylationGO:0018108720.066
regulation of cellular localizationGO:00603412630.065
ovulation cycleGO:0042698670.065
response to monosaccharideGO:00342841590.065
positive regulation of intracellular signal transductionGO:19025331380.065
regulation of protein modification processGO:00313991940.064
cell adhesionGO:00071551100.064
negative regulation of transportGO:00510511360.063
regulation of lipid metabolic processGO:0019216680.063
negative regulation of rna metabolic processGO:00512531230.061
positive regulation of cellular component organizationGO:00511302000.061
response to decreased oxygen levelsGO:00362932370.059
positive regulation of cellular component movementGO:00512721020.059
nitrogen compound transportGO:00717052290.059
cell activationGO:0001775970.059
regulation of cell migrationGO:00303341280.058
multicellular organismal reproductive processGO:00486092330.058
negative regulation of cell deathGO:00605482290.057
transcription from rna polymerase ii promoterGO:00063662520.057
positive regulation of rna biosynthetic processGO:19026801970.057
regulation of phosphorylationGO:00423252480.056
leukocyte activationGO:0045321760.056
cellular response to peptide hormone stimulusGO:00713751200.056
cellular response to organonitrogen compoundGO:00714171970.056
regulation of programmed cell deathGO:00430673410.056
cellular carbohydrate metabolic processGO:0044262720.055
positive regulation of protein metabolic processGO:00512471780.055
positive regulation of rna metabolic processGO:00512542030.055
erk1 and erk2 cascadeGO:0070371480.054
positive regulation of immune system processGO:0002684900.054
regulation of cell developmentGO:00602842630.053
axon developmentGO:0061564960.053
multicellular organism reproductionGO:00325042330.053
regulation of phosphorus metabolic processGO:00511743490.052
cellular response to oxygen containing compoundGO:19017013860.052
regulation of anion transportGO:0044070430.052
carboxylic acid metabolic processGO:00197522890.052
regulation of saliva secretionGO:004687730.052
cellular amine metabolic processGO:0044106380.051
negative regulation of secretionGO:0051048820.051
positive regulation of saliva secretionGO:004687830.051
acid secretionGO:0046717480.051
multi multicellular organism processGO:00447061380.050
cellular cation homeostasisGO:00300031800.050
regulation of epithelial cell proliferationGO:0050678490.049
regulation of cellular amine metabolic processGO:003323880.049
gonad developmentGO:00084061040.048
response to nutrient levelsGO:00316673700.048
positive regulation of protein phosphorylationGO:00019341350.048
negative regulation of response to stimulusGO:00485851550.048
positive regulation of phosphorus metabolic processGO:00105622620.048
female sex differentiationGO:0046660590.047
cell cycleGO:00070491010.047
positive regulation of response to stimulusGO:00485842850.046
chemical homeostasisGO:00488782920.046
inflammatory responseGO:00069541500.046
lipid transportGO:0006869610.046
regulation of muscle system processGO:0090257790.046
regulation of inflammatory responseGO:0050727480.046
organic hydroxy compound transportGO:0015850770.046
positive regulation of transportGO:00510502450.045
negative regulation of nucleic acid templated transcriptionGO:19035071170.045
peptidyl amino acid modificationGO:00181931260.044
cell migrationGO:00164771970.044
sex differentiationGO:00075481130.044
negative regulation of macromolecule metabolic processGO:00106052600.044
negative regulation of nucleobase containing compound metabolic processGO:00459341530.044
regulation of rna biosynthetic processGO:20011413810.044
single organism catabolic processGO:00447122830.043
hindlimb morphogenesisGO:003513720.043
kidney developmentGO:0001822670.043
development of primary sexual characteristicsGO:00451371070.042
neuron deathGO:00709971270.042
regulation of cellular protein metabolic processGO:00322682670.041
response to glucocorticoidGO:00513842230.040
eye morphogenesisGO:004859240.040
positive regulation of cell motilityGO:2000147970.040
regulation of neuron deathGO:19012141150.040
cellular amino acid metabolic processGO:00065201070.040
secretion by cellGO:00329402480.039
positive regulation of cell communicationGO:00106472710.039
positive regulation of catalytic activityGO:00430851840.039
epithelium developmentGO:0060429960.039
response to inorganic substanceGO:00100353770.039
neuron developmentGO:00486662860.039
urinary bladder smooth muscle contractionGO:001483240.039
negative regulation of secretion by cellGO:1903531720.038
divalent inorganic cation transportGO:00725111340.038
renal system developmentGO:0072001670.038
regulation of secretionGO:00510462240.037
positive regulation of molecular functionGO:00440932300.037
regulation of molecular functionGO:00650093980.037
regulation of defense responseGO:0031347680.037
positive regulation of signalingGO:00230562700.036
regulation of smooth muscle cell migrationGO:0014910360.036
regulation of multicellular organismal developmentGO:20000263760.035
regulation of cell differentiationGO:00455953200.035
regulation of cell cycleGO:0051726730.035
regulation of anatomical structure sizeGO:00900661350.035
negative regulation of programmed cell deathGO:00430691830.035
carboxylic acid transportGO:00469421150.035
regulation of response to stressGO:00801341260.035
regulation of cellular component organizationGO:00511283680.034
negative regulation of cell communicationGO:00106481580.034
positive regulation of signal transductionGO:00099671750.034
negative regulation of signalingGO:00230571570.033
organ morphogenesisGO:0009887750.033
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.033
organic hydroxy compound metabolic processGO:19016151150.033
regulation of immune system processGO:00026821230.033
regulation of response to woundingGO:1903034690.033
embryonic appendage morphogenesisGO:003511340.032
ribonucleotide metabolic processGO:00092592310.032
rhythmic processGO:00485111560.032
response to organophosphorusGO:00466831020.032
negative regulation of cell proliferationGO:00082851190.032
positive regulation of protein modification processGO:00314011420.032
organic substance catabolic processGO:19015753160.032
cellular response to stressGO:00335542690.032
female gonad developmentGO:0008585530.031
response to indole 3 methanolGO:007168020.031
reproductive system developmentGO:00614581280.031
phospholipid metabolic processGO:0006644610.031
embryonic skeletal system morphogenesisGO:004870430.031
response to antibioticGO:0046677390.031
positive regulation of somatostatin secretionGO:009027440.031
agingGO:00075682410.031
neural precursor cell proliferationGO:0061351230.031
regulation of synaptic transmissionGO:00508041410.031
peptidyl tyrosine modificationGO:0018212720.031
positive regulation of mapk cascadeGO:0043410920.030
positive regulation of protein kinase activityGO:0045860730.030
regulation of cellular component movementGO:00512701500.030
response to cytokineGO:00340972150.030
positive regulation of cell differentiationGO:00455972170.029
signal releaseGO:00230611450.029
reproductive structure developmentGO:00486081280.029
regulation of lipid biosynthetic processGO:0046890380.029
organic anion transportGO:00157111320.029
regulation of protein phosphorylationGO:00019321830.029
small molecule catabolic processGO:0044282590.029
positive regulation of cellular protein metabolic processGO:00322701670.029
single organism biosynthetic processGO:00447113420.029
ion transmembrane transportGO:00342203650.029
neuron differentiationGO:00301823680.028
regulation of excretionGO:0044062210.028
regulation of metal ion transportGO:00109591180.028
g protein coupled receptor signaling pathwayGO:00071862420.028
positive regulation of cell developmentGO:00107201760.028
oxoacid metabolic processGO:00434362900.028
response to hypoxiaGO:00016662310.028
neuropeptide signaling pathwayGO:0007218290.028
response to oxygen levelsGO:00704822650.028
sexual reproductionGO:00199531480.028
cell projection organizationGO:00300303020.028
positive regulation of synaptic plasticityGO:003191530.028
response to reactive oxygen speciesGO:00003021200.027
calcium ion transport into cytosolGO:0060402380.027
positive regulation of lipid biosynthetic processGO:0046889250.027
response to nicotineGO:0035094510.027
protein phosphorylationGO:00064683450.027
sequestering of calcium ionGO:005120880.027
vascular process in circulatory systemGO:0003018960.027
hormone biosynthetic processGO:0042446250.027
organelle organizationGO:00069962660.027
cell type specific apoptotic processGO:00972851340.026
positive regulation of nucleotide metabolic processGO:0045981910.026
positive regulation of transferase activityGO:0051347810.026
reproductionGO:00000032450.026
negative regulation of cellular biosynthetic processGO:00313271610.026
urogenital system developmentGO:0001655780.026
negative regulation of ion transportGO:0043271510.026
negative regulation of transcription dna templatedGO:00458921160.025
anatomical structure morphogenesisGO:00096532980.025
reactive oxygen species metabolic processGO:0072593370.025
positive regulation of neurogenesisGO:00507691650.025
activation of janus kinase activityGO:004297650.025
organophosphate metabolic processGO:00196373700.025
regulation of cellular ketone metabolic processGO:0010565270.025
female pregnancyGO:00075651220.025
smooth muscle contractionGO:0006939370.025
positive regulation of organelle organizationGO:0010638480.025
response to low density lipoprotein particleGO:005509840.025
reproductive processGO:00224143720.025
parturitionGO:0007567100.025
ameboidal type cell migrationGO:0001667260.025
response to glucoseGO:00097491360.025
response to purine containing compoundGO:00140741260.025
cellular response to acid chemicalGO:0071229750.025
macromolecule localizationGO:00330362520.025
regulation of anatomical structure morphogenesisGO:00226031410.025
organophosphate biosynthetic processGO:00904071430.025
regulation of cellular amino acid metabolic processGO:000652120.024
sensory perceptionGO:00076001010.024
regulation of nucleotide metabolic processGO:00061401170.024
cytosolic calcium ion transportGO:0060401390.024
lymphocyte activationGO:0046649430.024
locomotionGO:00400112370.024
nucleoside phosphate catabolic processGO:19012921400.024
sensory perception of painGO:0019233730.024
urinary tract smooth muscle contractionGO:001484840.024
response to osmotic stressGO:0006970420.024
phospholipase c activating g protein coupled receptor signaling pathwayGO:0007200270.024
positive regulation of cellular amino acid metabolic processGO:004576410.024
positive regulation of cellular component biogenesisGO:0044089550.023
developmental process involved in reproductionGO:00030061590.023
regulation of response to external stimulusGO:00321011060.023
regulation of calcium ion transportGO:0051924770.023
response to acid chemicalGO:00011012220.023
tube developmentGO:0035295890.023
cellular response to growth factor stimulusGO:00713631620.023
hepaticobiliary system developmentGO:0061008900.023
negative regulation of biosynthetic processGO:00098901680.023
carbohydrate catabolic processGO:0016052400.023
cell morphogenesis involved in differentiationGO:00009041190.023
response to painGO:0048265110.022
gamete generationGO:00072761240.022
regulation of behaviorGO:0050795610.022
cellular component biogenesisGO:00440853680.022
positive regulation of cell activationGO:0050867340.022
regulation of hydrolase activityGO:00513361430.022
digestive system processGO:0022600240.022
positive regulation of locomotionGO:00400171020.022
regulation of catalytic activityGO:00507903040.022
macromolecular complex subunit organizationGO:00439333390.021
prostate gland morphogenesisGO:006051220.021
positive regulation of muscle contractionGO:0045933220.021
circadian rhythmGO:0007623880.021
cytokine productionGO:0001816610.021
positive regulation of leukocyte activationGO:0002696300.021
positive regulation of secretionGO:00510471400.021
negative regulation of chronic inflammatory responseGO:000267720.021
response to extracellular stimulusGO:00099913800.021
regulation of locomotionGO:00400121480.021
negative regulation of homeostatic processGO:0032845470.021
response to electrical stimulusGO:0051602560.021
negative regulation of nervous system developmentGO:0051961790.020
response to hydrogen peroxideGO:0042542890.020
regulation of ion transmembrane transportGO:00347651210.020
circulatory system processGO:00030131830.020
sequestering of metal ionGO:005123890.020
ras protein signal transductionGO:0007265290.020
protein oligomerizationGO:00512591910.020
regulation of neural precursor cell proliferationGO:2000177160.020
purine nucleotide metabolic processGO:00061632290.020
negative regulation of macromolecule biosynthetic processGO:00105581480.020
limb morphogenesisGO:003510840.020
positive regulation of nervous system developmentGO:00519621780.020
calcium ion transportGO:00068161310.020
response to ketoneGO:19016541820.020
regulation of feeding behaviorGO:0060259140.020
cellular response to alcoholGO:0097306870.020
cation transmembrane transportGO:00986552630.019
micturitionGO:006007340.019
regulation of smooth muscle contractionGO:0006940290.019
regulation of ossificationGO:0030278320.019
epithelial cell proliferationGO:0050673540.019
negative regulation of calcium ion importGO:009028120.019
response to mechanical stimulusGO:00096121340.019
negative regulation of hormone secretionGO:0046888460.019
regulation of transferase activityGO:00513381230.019
defense responseGO:00069521940.019
carbohydrate metabolic processGO:00059751300.019
positive regulation of epithelial cell proliferationGO:0050679320.019
cellular hormone metabolic processGO:0034754490.019
organic acid metabolic processGO:00060822920.019
cellular catabolic processGO:00442482950.018
single organism carbohydrate catabolic processGO:0044724400.018
respiratory system developmentGO:0060541450.018
positive regulation of kinase activityGO:0033674770.018
regulation of nervous system developmentGO:00519602640.018
cellular response to hexose stimulusGO:0071331650.018
regulation of protein kinase activityGO:00458591050.018
regulation of organic acid transportGO:0032890350.018
regulation of transmembrane transportGO:00347621220.018
regulation of system processGO:00440572080.018
negative regulation of neurogenesisGO:0050768780.018
regulation of neurogenesisGO:00507672470.018
response to high light intensityGO:000964410.018
steroid biosynthetic processGO:0006694480.018
negative regulation of natural killer cell mediated immune response to tumor cellGO:000285610.018
hematopoietic progenitor cell differentiationGO:000224420.018
carbohydrate biosynthetic processGO:0016051420.018
regulation of endocrine processGO:0044060210.018
response to anoxiaGO:003405940.018
positive regulation of cellular amine metabolic processGO:003324030.018
multicellular organismal response to stressGO:0033555250.017
cellular response to steroid hormone stimulusGO:0071383930.017
response to transition metal nanoparticleGO:19902671220.017
cellular component assemblyGO:00226073600.017
detection of chemical stimulus involved in sensory perception of bitter tasteGO:000158040.017
appendage morphogenesisGO:003510740.017
behaviorGO:00076102050.017
drug transmembrane transportGO:0006855130.017
palate developmentGO:006002120.017
regulation of purine nucleotide metabolic processGO:19005421150.017
negative regulation of cell developmentGO:0010721820.017
forebrain developmentGO:0030900980.017
small gtpase mediated signal transductionGO:0007264360.017
single organism organelle organizationGO:19025891800.017
regulation of defecationGO:200029210.017
associative learningGO:0008306190.016
cellular response to lipopolysaccharideGO:0071222550.016
regulation of catabolic processGO:00098941130.016
regulation of cell motilityGO:20001451310.016
negative regulation of multicellular organismal processGO:00512412030.016
negative regulation of luteinizing hormone secretionGO:003368540.016
prostate gland epithelium morphogenesisGO:006074020.016
endocrine processGO:0050886320.016
positive regulation of hormone secretionGO:0046887650.016
negative regulation of cellular protein metabolic processGO:00322691060.016
glucose homeostasisGO:0042593750.016
catabolic processGO:00090563510.016
response to metal ionGO:00100382530.016
macromolecular complex assemblyGO:00650032730.016
positive regulation of serotonin secretionGO:001406410.016
regulation of jak stat cascadeGO:0046425210.016
peptide secretionGO:0002790860.016
positive regulation of the force of heart contraction by epinephrineGO:000305910.016
protein complex subunit organizationGO:00718223020.015
response to light stimulusGO:0009416520.015
protein complex biogenesisGO:00702712630.015
release of sequestered calcium ion into cytosolGO:0051209250.015
regulation of peptide hormone secretionGO:0090276800.015
energy reserve metabolic processGO:0006112250.015
positive regulation of smooth muscle contractionGO:0045987180.015
regulation of cellular catabolic processGO:00313291010.015
organic hydroxy compound biosynthetic processGO:1901617510.015
transformation of host cell by virusGO:001908740.015
regulation of glutamate secretionGO:0014048170.015
organic cyclic compound catabolic processGO:19013611750.015
cellular response to glucose stimulusGO:0071333650.015
purine ribonucleotide metabolic processGO:00091502270.015
cell cycle processGO:0022402570.015
memoryGO:0007613540.015
regulation of immune response to tumor cellGO:000283730.015
neuron projection developmentGO:00311752730.015
cellular response to metal ionGO:0071248550.015
pallium developmentGO:0021543420.015
negative regulation of developmental processGO:00510931250.015
hormone metabolic processGO:0042445690.015
cellular response to low density lipoprotein particle stimulusGO:007140430.015
response to retinoic acidGO:0032526630.015
muscle system processGO:00030121150.015
positive regulation of lipid metabolic processGO:0045834330.014
collagen catabolic processGO:003057420.014
skeletal system developmentGO:0001501410.014
embryonic hindlimb morphogenesisGO:003511620.014
response to cgmpGO:007030530.014
positive regulation of protein serine threonine kinase activityGO:0071902520.014
cellular response to carbohydrate stimulusGO:0071322720.014
cognitionGO:0050890920.014
regulation of cell cycle processGO:0010564310.014
peptide transportGO:0015833970.014
purine ribonucleoside metabolic processGO:00461281680.014
carbohydrate derivative metabolic processGO:19011353460.014
cell morphogenesis involved in neuron differentiationGO:00486671060.014
respiratory tube developmentGO:0030323430.014
maintenance of locationGO:0051235170.014
mechanoreceptor differentiationGO:004249020.014
cellular response to cytokine stimulusGO:00713451270.014
limbic system developmentGO:0021761380.014
syncytium formation by plasma membrane fusionGO:000076830.013
metal ion transportGO:00300012890.013
smooth muscle cell migrationGO:0014909360.013
regulation of vasoconstrictionGO:0019229440.013
regulation of cell activationGO:0050865500.013
epithelial cell differentiationGO:0030855710.013
oligopeptide transportGO:000685740.013
nucleotide metabolic processGO:00091172790.013
muscle cell migrationGO:0014812360.013
anion transmembrane transportGO:0098656770.013
nucleobase containing small molecule metabolic processGO:00550863160.013
organic acid transportGO:00158491160.013
ovulation cycle processGO:0022602500.013
cellular component morphogenesisGO:00329891550.013
response to campGO:0051591910.013
embryonic limb morphogenesisGO:003032640.013
peristalsisGO:003043220.013
pyridine containing compound metabolic processGO:0072524320.013
response to iron iii ionGO:001004160.013
response to molecule of bacterial originGO:00022371940.013
amine transportGO:0015837570.013
positive regulation of secretion by cellGO:19035321280.013
steroid metabolic processGO:0008202730.012
regulation of cellular carbohydrate metabolic processGO:0010675390.012

Fam38b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.053
sensory system diseaseDOID:005015500.053
disease of anatomical entityDOID:700.053
eye and adnexa diseaseDOID:149200.051
eye diseaseDOID:561400.016
connective tissue diseaseDOID:6500.012
musculoskeletal system diseaseDOID:1700.012