IMP: Integrative Multi-species Prediction

Rattus norvegicus

96 known processes

Stat6

signal transducer and activator of transcription 6

RGD: 1309063
Ensembl: ENSRNOG00000025023
Entrez: 362896
UniProtKB: Q1KQ07

Process Predictions
Disease Predictions

Stat6 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
localization of cell	GO:0051674	202	0.642	Fly
regulation of cell proliferation	GO:0042127	359	0.622	Mouse Rat Fly
rna metabolic process	GO:0016070	406	0.560
cellular response to endogenous stimulus	GO:0071495	377	0.471	Rat
response to acid chemical	GO:0001101	222	0.445
transcription from rna polymerase ii promoter	GO:0006366	252	0.422
macromolecule localization	GO:0033036	252	0.392
protein complex assembly	GO:0006461	263	0.384
response to external biotic stimulus	GO:0043207	221	0.381	Rat Fly
regulation of transcription dna templated	GO:0006355	374	0.381
response to estrogen	GO:0043627	232	0.373	Rat
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.363
cellular component biogenesis	GO:0044085	368	0.356
positive regulation of biosynthetic process	GO:0009891	319	0.348
positive regulation of cell motility	GO:2000147	97	0.338
cellular component assembly	GO:0022607	360	0.335
response to corticosteroid	GO:0031960	235	0.322
regulation of anatomical structure morphogenesis	GO:0022603	141	0.319	Rat
regulation of rna biosynthetic process	GO:2001141	381	0.314
aging	GO:0007568	241	0.312	Rat
regeneration	GO:0031099	163	0.307
intracellular signal transduction	GO:0035556	314	0.301	Rat Fly
response to carbohydrate	GO:0009743	183	0.297
cellular response to organic cyclic compound	GO:0071407	202	0.297
regulation of cell motility	GO:2000145	131	0.295
positive regulation of response to stimulus	GO:0048584	285	0.288	Mouse
cell projection organization	GO:0030030	302	0.284
positive regulation of cell death	GO:0010942	184	0.281
transcription dna templated	GO:0006351	377	0.280
positive regulation of cell communication	GO:0010647	271	0.279
neuron differentiation	GO:0030182	368	0.270
response to nutrient levels	GO:0031667	370	0.266	Rat
negative regulation of multicellular organismal process	GO:0051241	203	0.263	Rat
cell motility	GO:0048870	202	0.260	Fly
oxoacid metabolic process	GO:0043436	290	0.260
response to other organism	GO:0051707	220	0.254	Rat Fly
cellular response to hormone stimulus	GO:0032870	247	0.254	Rat
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.252
response to peptide hormone	GO:0043434	278	0.249	Rat
positive regulation of cellular biosynthetic process	GO:0031328	295	0.246
negative regulation of macromolecule metabolic process	GO:0010605	260	0.236	Mouse Rat
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.230	Mouse Rat
response to vitamin d	GO:0033280	34	0.230
oxidation reduction process	GO:0055114	304	0.229
response to nutrient	GO:0007584	248	0.225	Rat
response to extracellular stimulus	GO:0009991	380	0.219	Rat
positive regulation of multicellular organismal process	GO:0051240	387	0.218	Mouse
regulation of signal transduction	GO:0009966	318	0.215	Fly
positive regulation of cellular component movement	GO:0051272	102	0.206	Rat
response to bacterium	GO:0009617	200	0.202	Rat Fly
negative regulation of cellular metabolic process	GO:0031324	281	0.201	Mouse Rat
response to molecule of bacterial origin	GO:0002237	194	0.198	Rat Fly
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.196
regulation of nucleic acid templated transcription	GO:1903506	380	0.196
positive regulation of cellular component organization	GO:0051130	200	0.192
response to peptide	GO:1901652	292	0.191	Rat
response to monosaccharide	GO:0034284	159	0.190
negative regulation of gene expression	GO:0010629	199	0.188	Mouse Rat
regulation of rna metabolic process	GO:0051252	391	0.188
establishment of protein localization	GO:0045184	141	0.187
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.187
positive regulation of cell migration	GO:0030335	96	0.186
positive regulation of transcription dna templated	GO:0045893	197	0.184
macromolecular complex subunit organization	GO:0043933	339	0.184
negative regulation of developmental process	GO:0051093	125	0.180	Rat Fly
response to glucocorticoid	GO:0051384	223	0.180
positive regulation of gene expression	GO:0010628	244	0.179
neuron projection development	GO:0031175	273	0.178
negative regulation of metabolic process	GO:0009892	331	0.174	Mouse Rat
response to hydrogen peroxide	GO:0042542	89	0.173
regulation of protein metabolic process	GO:0051246	289	0.172
regulation of locomotion	GO:0040012	148	0.168
positive regulation of rna biosynthetic process	GO:1902680	197	0.164
response to cytokine	GO:0034097	215	0.163
cellular amino acid metabolic process	GO:0006520	107	0.158
regulation of cell development	GO:0060284	263	0.158	Rat
response to purine containing compound	GO:0014074	126	0.158	Rat
renal system development	GO:0072001	67	0.157	Rat
defense response	GO:0006952	194	0.156	Rat Fly
cell migration	GO:0016477	197	0.155	Fly
regulation of cellular protein metabolic process	GO:0032268	267	0.154
protein complex subunit organization	GO:0071822	302	0.153
carboxylic acid metabolic process	GO:0019752	289	0.152
negative regulation of response to stimulus	GO:0048585	155	0.151	Mouse Fly
negative regulation of rna metabolic process	GO:0051253	123	0.150	Mouse Rat
organic acid metabolic process	GO:0006082	292	0.149
rna biosynthetic process	GO:0032774	380	0.149
cellular response to nitrogen compound	GO:1901699	210	0.149
regulation of molecular function	GO:0065009	398	0.148
protein transport	GO:0015031	132	0.148
protein oligomerization	GO:0051259	191	0.143
response to glucose	GO:0009749	136	0.143
urogenital system development	GO:0001655	78	0.142	Rat
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.140
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.140	Mouse Rat
nucleic acid templated transcription	GO:0097659	379	0.138
positive regulation of cell differentiation	GO:0045597	217	0.138
response to wounding	GO:0009611	254	0.134
positive regulation of protein phosphorylation	GO:0001934	135	0.129
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	10	0.129
response to mechanical stimulus	GO:0009612	134	0.129	Rat
positive regulation of cell development	GO:0010720	176	0.128
response to tumor necrosis factor	GO:0034612	56	0.128
neuron development	GO:0048666	286	0.128
regulation of cellular component organization	GO:0051128	368	0.128	Rat
response to estradiol	GO:0032355	164	0.126	Rat
regulation of cell projection organization	GO:0031344	175	0.122
wound healing	GO:0042060	122	0.122
protein complex biogenesis	GO:0070271	263	0.116
response to vitamin	GO:0033273	131	0.114
regulation of nervous system development	GO:0051960	264	0.113
positive regulation of biomineral tissue development	GO:0070169	4	0.113
muscle cell proliferation	GO:0033002	84	0.113	Rat
response to interleukin 1	GO:0070555	55	0.112
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.111	Mouse Rat
central nervous system development	GO:0007417	311	0.110
response to amino acid	GO:0043200	75	0.109
macromolecular complex assembly	GO:0065003	273	0.109
regulation of protein localization	GO:0032880	81	0.108
cellular response to external stimulus	GO:0071496	118	0.108
phospholipid metabolic process	GO:0006644	61	0.107
protein localization	GO:0008104	191	0.107
regulation of response to stress	GO:0080134	126	0.105	Fly
reproductive system development	GO:0061458	128	0.105	Rat
cellular response to oxygen containing compound	GO:1901701	386	0.104
intracellular transport	GO:0046907	185	0.104	Rat
response to hexose	GO:0009746	144	0.103
neurological system process	GO:0050877	219	0.103	Fly
cellular response to lipid	GO:0071396	201	0.103	Fly
positive regulation of molecular function	GO:0044093	230	0.102
negative regulation of biosynthetic process	GO:0009890	168	0.100	Mouse Rat
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.100
regulation of cellular component movement	GO:0051270	150	0.099	Rat
anatomical structure morphogenesis	GO:0009653	298	0.099	Mouse Rat Fly
regulation of protein phosphorylation	GO:0001932	183	0.098
regulation of protein modification process	GO:0031399	194	0.098
positive regulation of signaling	GO:0023056	270	0.097
regulation of cell morphogenesis	GO:0022604	77	0.097	Rat
cellular response to biotic stimulus	GO:0071216	59	0.097	Fly
cellular amine metabolic process	GO:0044106	38	0.097
response to camp	GO:0051591	91	0.096	Rat
regulation of cell migration	GO:0030334	128	0.096
cellular response to insulin stimulus	GO:0032869	81	0.095	Rat
positive regulation of cell projection organization	GO:0031346	111	0.095
positive regulation of protein metabolic process	GO:0051247	178	0.095
lipid metabolic process	GO:0006629	283	0.095
single organism biosynthetic process	GO:0044711	342	0.095	Rat
homeostatic process	GO:0042592	331	0.095
negative regulation of cell differentiation	GO:0045596	99	0.094	Rat Fly
regulation of cellular component biogenesis	GO:0044087	86	0.093
positive regulation of developmental process	GO:0051094	283	0.092	Mouse
axon development	GO:0061564	96	0.092
protein maturation	GO:0051604	68	0.090
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.090	Fly
positive regulation of rna metabolic process	GO:0051254	203	0.089
single organism reproductive process	GO:0044702	297	0.088	Rat Fly
cellular component morphogenesis	GO:0032989	155	0.088	Rat Fly
organic substance catabolic process	GO:1901575	316	0.087
negative regulation of cell communication	GO:0010648	158	0.087	Fly
apoptotic process	GO:0006915	381	0.087
cell projection assembly	GO:0030031	21	0.086
developmental process involved in reproduction	GO:0003006	159	0.085	Rat Fly
regulation of membrane potential	GO:0042391	110	0.084
regulation of intracellular signal transduction	GO:1902531	218	0.082	Fly
blood vessel development	GO:0001568	69	0.082
tissue development	GO:0009888	252	0.081	Mouse Rat Fly
positive regulation of neurogenesis	GO:0050769	165	0.081
response to reactive oxygen species	GO:0000302	120	0.081
regulation of phosphate metabolic process	GO:0019220	349	0.081	Rat
transforming growth factor beta receptor signaling pathway	GO:0007179	18	0.080
retinoic acid receptor signaling pathway	GO:0048384	7	0.080
negative regulation of transcription dna templated	GO:0045892	116	0.080	Mouse Rat
positive regulation of phosphorus metabolic process	GO:0010562	262	0.080	Rat
regulation of neurogenesis	GO:0050767	247	0.080
positive regulation of transferase activity	GO:0051347	81	0.079
regulation of multicellular organismal development	GO:2000026	376	0.079	Mouse Rat
negative regulation of signaling	GO:0023057	157	0.078	Fly
cellular response to lipopolysaccharide	GO:0071222	55	0.077	Fly
positive regulation of apoptotic process	GO:0043065	154	0.076
positive regulation of cellular protein metabolic process	GO:0032270	167	0.076
response to lipopolysaccharide	GO:0032496	191	0.076	Rat Fly
regulation of cellular amine metabolic process	GO:0033238	8	0.076
regulation of neuron differentiation	GO:0045664	208	0.075
negative regulation of insulin receptor signaling pathway	GO:0046627	10	0.075
regulation of cellular ketone metabolic process	GO:0010565	27	0.075
regulation of cell adhesion	GO:0030155	52	0.075
negative regulation of cell development	GO:0010721	82	0.075	Rat
catabolic process	GO:0009056	351	0.074
generation of precursor metabolites and energy	GO:0006091	62	0.074
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.074	Mouse Rat
negative regulation of cellular response to insulin stimulus	GO:1900077	11	0.074
regulation of neuron death	GO:1901214	115	0.073	Rat
regulation of phosphorus metabolic process	GO:0051174	349	0.073	Rat
cellular response to peptide hormone stimulus	GO:0071375	120	0.073	Rat
positive regulation of cell proliferation	GO:0008284	249	0.072	Rat Fly
response to oxygen levels	GO:0070482	265	0.072	Rat
regulation of catalytic activity	GO:0050790	304	0.072
single organism catabolic process	GO:0044712	283	0.071
response to inorganic substance	GO:0010035	377	0.071
cell morphogenesis involved in differentiation	GO:0000904	119	0.070	Rat Fly
cellular nitrogen compound catabolic process	GO:0044270	163	0.070
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.070
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.070	Mouse Rat
activation of protein kinase activity	GO:0032147	47	0.070
cellular carbohydrate metabolic process	GO:0044262	72	0.069
negative regulation of tyrosine phosphorylation of stat5 protein	GO:0042524	1	0.069
response to ketone	GO:1901654	182	0.068
positive regulation of signal transduction	GO:0009967	175	0.068
head development	GO:0060322	247	0.068
cellular response to tumor necrosis factor	GO:0071356	46	0.067
organophosphate metabolic process	GO:0019637	370	0.065	Rat
gliogenesis	GO:0042063	93	0.065
regulation of protein secretion	GO:0050708	28	0.065
purine containing compound metabolic process	GO:0072521	253	0.064	Rat
cell activation	GO:0001775	97	0.064	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	2	0.064
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	5	0.063
organonitrogen compound catabolic process	GO:1901565	179	0.063
positive regulation of protein modification process	GO:0031401	142	0.063
secretion	GO:0046903	307	0.063	Rat
regulation of establishment of protein localization	GO:0070201	69	0.062
protein phosphorylation	GO:0006468	345	0.062
response to aluminum ion	GO:0010044	10	0.061
cell adhesion	GO:0007155	110	0.061
leukocyte activation	GO:0045321	76	0.061	Mouse
purine ribonucleotide metabolic process	GO:0009150	227	0.061	Rat
response to axon injury	GO:0048678	59	0.061
regulation of apoptotic process	GO:0042981	335	0.061
regulation of kinase activity	GO:0043549	117	0.061
negative regulation of protein import into nucleus translocation	GO:0033159	1	0.060
cellular response to steroid hormone stimulus	GO:0071383	93	0.060
neuronal action potential	GO:0019228	35	0.060
negative regulation of cellular biosynthetic process	GO:0031327	161	0.060	Mouse Rat
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.059	Rat
organ regeneration	GO:0031100	101	0.059
calcium ion transport	GO:0006816	131	0.059
mesenchymal cell proliferation	GO:0010463	4	0.058	Rat
response to hypoxia	GO:0001666	231	0.057	Rat
positive regulation of phosphate metabolic process	GO:0045937	262	0.057	Rat
response to temperature stimulus	GO:0009266	94	0.057
regulation of system process	GO:0044057	208	0.057
single organism membrane organization	GO:0044802	74	0.056	Rat
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	8	0.055
protein autophosphorylation	GO:0046777	66	0.055
negative regulation of cellular protein metabolic process	GO:0032269	106	0.055
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.054
regulation of lipid metabolic process	GO:0019216	68	0.054
gland development	GO:0048732	155	0.054	Mouse Rat Fly
positive regulation of mitochondrion organization	GO:0010822	4	0.054
lymphocyte activation	GO:0046649	43	0.054	Mouse
regulation of programmed cell death	GO:0043067	341	0.054
ribonucleotide metabolic process	GO:0009259	231	0.053	Rat
microvillus assembly	GO:0030033	2	0.053
immune response	GO:0006955	104	0.053	Mouse Fly
reproduction	GO:0000003	245	0.053	Rat Fly
regulation of transferase activity	GO:0051338	123	0.052
regulation of protein import into nucleus	GO:0042306	24	0.052
response to mineralocorticoid	GO:0051385	49	0.051
regulation of protein transport	GO:0051223	68	0.051
biological adhesion	GO:0022610	110	0.051
purine nucleotide metabolic process	GO:0006163	229	0.050	Rat
salivary gland development	GO:0007431	3	0.050
single organism intracellular transport	GO:1902582	166	0.050	Rat
regulation of endocytosis	GO:0030100	42	0.050
regulation of phosphorylation	GO:0042325	248	0.050
cellular component movement	GO:0006928	248	0.050	Rat Fly
intracellular protein transport	GO:0006886	79	0.050
positive regulation of neuron projection development	GO:0010976	99	0.049
positive regulation of nervous system development	GO:0051962	178	0.049
macrophage chemotaxis	GO:0048246	2	0.049
carbohydrate derivative metabolic process	GO:1901135	346	0.049	Rat
female gonad development	GO:0008585	53	0.049	Rat
response to insulin	GO:0032868	133	0.049	Rat
negative regulation of cell death	GO:0060548	229	0.049	Rat
cellular response to acid chemical	GO:0071229	75	0.048
negative regulation of nervous system development	GO:0051961	79	0.048
negative regulation of rna biosynthetic process	GO:1902679	118	0.048	Mouse Rat
metal ion homeostasis	GO:0055065	186	0.048
cellular response to organonitrogen compound	GO:0071417	197	0.048	Rat
intracellular receptor signaling pathway	GO:0030522	35	0.048
negative regulation of phosphorus metabolic process	GO:0010563	80	0.048
negative regulation of cell proliferation	GO:0008285	119	0.047
positive regulation of endothelial cell migration	GO:0010595	4	0.047
reactive oxygen species metabolic process	GO:0072593	37	0.047	Rat
positive regulation of intracellular signal transduction	GO:1902533	138	0.047
cell morphogenesis	GO:0000902	142	0.047	Rat Fly
response to biotic stimulus	GO:0009607	226	0.047	Rat Fly
brain development	GO:0007420	247	0.046
positive regulation of programmed cell death	GO:0043068	157	0.046
positive regulation of smooth muscle cell proliferation	GO:0048661	51	0.046	Rat
protein targeting	GO:0006605	61	0.046
nucleoside triphosphate metabolic process	GO:0009141	144	0.045	Rat
ensheathment of neurons	GO:0007272	40	0.045
liver development	GO:0001889	90	0.045	Rat
response to retinoic acid	GO:0032526	63	0.045
regulation of defense response	GO:0031347	68	0.044	Fly
reproductive process	GO:0022414	372	0.044	Rat Fly
regulation of cellular localization	GO:0060341	263	0.044
regulation of translation	GO:0006417	27	0.044
jak stat cascade	GO:0007259	26	0.044	Rat Fly
behavior	GO:0007610	205	0.044	Fly
regulation of protein kinase activity	GO:0045859	105	0.043
positive regulation of phosphatidylinositol 3 kinase activity	GO:0043552	2	0.043
memory	GO:0007613	54	0.043	Fly
cell cell junction organization	GO:0045216	20	0.042
locomotion	GO:0040011	237	0.042	Fly
positive regulation of response to external stimulus	GO:0032103	51	0.042
circulatory system development	GO:0072359	134	0.042
positive regulation of cell adhesion	GO:0045785	30	0.042
transmembrane transport	GO:0055085	412	0.042
insulin receptor signaling pathway	GO:0008286	24	0.042
programmed cell death	GO:0012501	392	0.042
t cell homeostasis	GO:0043029	2	0.042
protein homooligomerization	GO:0051260	91	0.041
positive regulation of protein kinase activity	GO:0045860	73	0.041
organic cyclic compound catabolic process	GO:1901361	175	0.041
positive regulation of lipid kinase activity	GO:0090218	2	0.041
reactive oxygen species biosynthetic process	GO:1903409	8	0.041	Rat
cellular response to mechanical stimulus	GO:0071260	48	0.041
negative regulation of protein phosphorylation	GO:0001933	44	0.041
cellular homeostasis	GO:0019725	252	0.041
membrane organization	GO:0061024	94	0.041	Rat
cytoplasmic transport	GO:0016482	115	0.040
regulation of cell differentiation	GO:0045595	320	0.040	Rat Fly
regulation of protein targeting	GO:1903533	28	0.040
peptidyl amino acid modification	GO:0018193	126	0.040
activation of protein kinase b activity	GO:0032148	3	0.040
cell projection morphogenesis	GO:0048858	123	0.040
positive regulation of release of cytochrome c from mitochondria	GO:0090200	3	0.039
cell junction organization	GO:0034330	21	0.039
cellular protein localization	GO:0034613	122	0.039
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.039	Rat
cellular response to molecule of bacterial origin	GO:0071219	56	0.039	Fly
negative regulation of neuron apoptotic process	GO:0043524	45	0.039
purine nucleoside metabolic process	GO:0042278	169	0.039	Rat
regulation of smooth muscle cell proliferation	GO:0048660	75	0.038	Rat
cellular response to peptide	GO:1901653	133	0.038	Rat
alpha beta t cell differentiation	GO:0046632	2	0.038	Mouse
gamete generation	GO:0007276	124	0.038	Fly
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.038
cellular response to cytokine stimulus	GO:0071345	127	0.037
appendage morphogenesis	GO:0035107	4	0.037
blood circulation	GO:0008015	183	0.037	Rat
cellular macromolecule localization	GO:0070727	122	0.037
response to growth factor	GO:0070848	189	0.036	Rat
regulation of response to external stimulus	GO:0032101	106	0.036	Fly
positive regulation of kinase activity	GO:0033674	77	0.036
vasculogenesis	GO:0001570	3	0.036
axon ensheathment	GO:0008366	40	0.036
protein heterooligomerization	GO:0051291	89	0.036
purine containing compound catabolic process	GO:0072523	138	0.036
organ formation	GO:0048645	3	0.036
embryonic neurocranium morphogenesis	GO:0048702	2	0.036
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.036
glial cell apoptotic process	GO:0034349	8	0.035
ribonucleotide catabolic process	GO:0009261	136	0.035
regulation of anatomical structure size	GO:0090066	135	0.035
ameboidal type cell migration	GO:0001667	26	0.035	Fly
cellular chemical homeostasis	GO:0055082	247	0.035
dna metabolic process	GO:0006259	96	0.035	Mouse
glycosyl compound metabolic process	GO:1901657	182	0.035	Rat
vesicle mediated transport	GO:0016192	181	0.034
secretion by cell	GO:0032940	248	0.034
positive regulation of neuron differentiation	GO:0045666	126	0.034
nucleoside phosphate metabolic process	GO:0006753	283	0.034	Rat
positive regulation of bone mineralization	GO:0030501	4	0.034
organelle organization	GO:0006996	266	0.034	Rat
actin filament bundle organization	GO:0061572	19	0.034
smooth muscle cell proliferation	GO:0048659	77	0.034	Rat
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	27	0.034
b cell differentiation	GO:0030183	2	0.034
single organism behavior	GO:0044708	130	0.034	Fly
cytokine production	GO:0001816	61	0.033
positive regulation of protein secretion	GO:0050714	19	0.033
regulation of response to wounding	GO:1903034	69	0.033
regulation of vesicle mediated transport	GO:0060627	81	0.033
smad protein complex assembly	GO:0007183	1	0.033
regulation of neuron projection development	GO:0010975	161	0.033
cellular catabolic process	GO:0044248	295	0.033
glial cell differentiation	GO:0010001	65	0.032
female pregnancy	GO:0007565	122	0.032
nucleobase containing small molecule metabolic process	GO:0055086	316	0.032	Rat
spindle organization	GO:0007051	2	0.032
nucleobase containing compound catabolic process	GO:0034655	152	0.032
negative regulation of phosphate metabolic process	GO:0045936	80	0.032
maintenance of location	GO:0051235	17	0.032
negative regulation of signal transduction	GO:0009968	83	0.032	Fly
multicellular organismal reproductive process	GO:0048609	233	0.031	Rat Fly
cardiovascular system development	GO:0072358	134	0.031
glycosyl compound catabolic process	GO:1901658	126	0.031
positive regulation of smooth muscle cell migration	GO:0014911	27	0.031
organ morphogenesis	GO:0009887	75	0.031	Mouse Rat Fly
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.031	Rat
translation	GO:0006412	35	0.031
neuron projection regeneration	GO:0031102	35	0.031
negative regulation of activation of jak2 kinase activity	GO:1902569	1	0.031
tissue regeneration	GO:0042246	36	0.031
negative regulation of protein metabolic process	GO:0051248	114	0.031
formation of primary germ layer	GO:0001704	1	0.031
fatty acid transmembrane transport	GO:1902001	3	0.031
response to transition metal nanoparticle	GO:1990267	122	0.030
embryonic cranial skeleton morphogenesis	GO:0048701	2	0.030
rhythmic process	GO:0048511	156	0.030	Rat
peptidyl tyrosine modification	GO:0018212	72	0.030
vascular process in circulatory system	GO:0003018	96	0.030
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.030	Rat
myelination	GO:0042552	39	0.030
camera type eye development	GO:0043010	48	0.030
sulfur compound metabolic process	GO:0006790	70	0.030
regulation of immune system process	GO:0002682	123	0.030	Mouse Fly
kidney development	GO:0001822	67	0.030	Rat
protein import	GO:0017038	37	0.030
chemotaxis	GO:0006935	66	0.030
regulation of ion transport	GO:0043269	245	0.029
negative regulation of transport	GO:0051051	136	0.029
divalent inorganic cation transport	GO:0072511	134	0.029
regulation of map kinase activity	GO:0043405	53	0.029
protein localization to nucleus	GO:0034504	39	0.029
polysaccharide metabolic process	GO:0005976	25	0.029
negative regulation of programmed cell death	GO:0043069	183	0.029
protein import into nucleus	GO:0006606	35	0.029
positive regulation of locomotion	GO:0040017	102	0.029
calcium ion homeostasis	GO:0055074	162	0.028
bmp signaling pathway	GO:0030509	4	0.028
synaptic growth at neuromuscular junction	GO:0051124	1	0.028
positive regulation of phosphorylation	GO:0042327	177	0.028
cation transport	GO:0006812	382	0.028
protein targeting to nucleus	GO:0044744	35	0.028
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	3	0.028
sodium ion transport	GO:0006814	82	0.028
response to transforming growth factor beta	GO:0071559	46	0.027
reproductive structure development	GO:0048608	128	0.027	Rat
positive regulation of immune system process	GO:0002684	90	0.027	Mouse
cellular lipid metabolic process	GO:0044255	208	0.027
neuron apoptotic process	GO:0051402	88	0.027
positive regulation of mesenchymal cell proliferation	GO:0002053	4	0.027	Rat
monovalent inorganic cation transport	GO:0015672	172	0.027
chemical homeostasis	GO:0048878	292	0.027
nucleoside metabolic process	GO:0009116	179	0.027	Rat
regulation of muscle organ development	GO:0048634	26	0.026
positive regulation of secretion by cell	GO:1903532	128	0.026
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.026
positive regulation of immunoglobulin production	GO:0002639	4	0.026	Mouse
positive regulation of hydrolase activity	GO:0051345	86	0.026
nucleoside phosphate catabolic process	GO:1901292	140	0.026
positive regulation of catalytic activity	GO:0043085	184	0.026
cellular response to stress	GO:0033554	269	0.026
learning or memory	GO:0007611	90	0.026	Fly
negative regulation of cellular component organization	GO:0051129	83	0.026	Rat
nuclear import	GO:0051170	35	0.026
t cell tolerance induction	GO:0002517	3	0.026
positive regulation of protein transport	GO:0051222	41	0.026
cellular response to nutrient levels	GO:0031669	60	0.026
positive regulation of transport	GO:0051050	245	0.026
response to alkaloid	GO:0043279	132	0.026
positive regulation of protein serine threonine kinase activity	GO:0071902	52	0.026
peptidyl tyrosine phosphorylation	GO:0018108	72	0.026
organ growth	GO:0035265	24	0.026
eye morphogenesis	GO:0048592	4	0.025
response to organophosphorus	GO:0046683	102	0.025	Rat
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.025	Rat
negative regulation of molecular function	GO:0044092	133	0.025
positive regulation of map kinase activity	GO:0043406	46	0.025
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	41	0.025
regulation of carbohydrate metabolic process	GO:0006109	41	0.025
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.025	Mouse Rat
protein localization to organelle	GO:0033365	57	0.025
regulation of blood vessel size	GO:0050880	89	0.025
myeloid leukocyte differentiation	GO:0002573	20	0.025
positive regulation of cellular catabolic process	GO:0031331	71	0.025
negative regulation of intracellular signal transduction	GO:1902532	38	0.025
single organism organelle organization	GO:1902589	180	0.025	Rat
transmission of nerve impulse	GO:0019226	42	0.025
gonad development	GO:0008406	104	0.025	Rat
negative regulation of neuron differentiation	GO:0045665	62	0.024
organophosphate catabolic process	GO:0046434	148	0.024
mesoderm development	GO:0007498	2	0.024
response to oxidative stress	GO:0006979	186	0.024
positive regulation of cellular component biogenesis	GO:0044089	55	0.024
nucleotide metabolic process	GO:0009117	279	0.024	Rat
cellular response to extracellular stimulus	GO:0031668	73	0.024
organonitrogen compound biosynthetic process	GO:1901566	167	0.024	Rat
regulation of organ formation	GO:0003156	2	0.024
male sex differentiation	GO:0046661	64	0.024
regulation of hydrolase activity	GO:0051336	143	0.024
dephosphorylation	GO:0016311	98	0.024
nitrogen compound transport	GO:0071705	229	0.024
telencephalon development	GO:0021537	62	0.024
t cell activation	GO:0042110	29	0.024	Mouse
cytoskeleton organization	GO:0007010	111	0.024
cellular glucan metabolic process	GO:0006073	23	0.023

Stat6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
large intestine cancer	DOID:5672	0.024
organ system cancer	DOID:0050686	0.024
disease of cellular proliferation	DOID:14566	0.024
colorectal cancer	DOID:9256	0.024
intestinal cancer	DOID:10155	0.024
colon cancer	DOID:219	0.024
cancer	DOID:162	0.024
gastrointestinal system cancer	DOID:3119	0.024

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