IMP: Integrative Multi-species Prediction

Rattus norvegicus

120 known processes

Crebbp

CREB binding protein

(Aliases: CBP,RTS,RSTS)

RGD: 2401
Entrez: 54244
Ensembl: ENSRNOG00000005330
UniProtKB: F1M9G7

Process Predictions
Disease Predictions

Crebbp biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.593
transcription dna templated	GO:0006351	377	0.473
regulation of rna metabolic process	GO:0051252	391	0.378
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.368
rna biosynthetic process	GO:0032774	380	0.355
positive regulation of gene expression	GO:0010628	244	0.345
positive regulation of rna biosynthetic process	GO:1902680	197	0.263
nucleic acid templated transcription	GO:0097659	379	0.249
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.243
rna metabolic process	GO:0016070	406	0.238
regulation of transcription dna templated	GO:0006355	374	0.238
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.233
positive regulation of rna metabolic process	GO:0051254	203	0.225
positive regulation of biosynthetic process	GO:0009891	319	0.224
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.202	Human Rat
regulation of nucleic acid templated transcription	GO:1903506	380	0.200
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.188
regulation of rna biosynthetic process	GO:2001141	381	0.172
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.166
positive regulation of transcription dna templated	GO:0045893	197	0.157
negative regulation of gene expression	GO:0010629	199	0.156	Human Rat
positive regulation of cellular biosynthetic process	GO:0031328	295	0.143
negative regulation of rna biosynthetic process	GO:1902679	118	0.124	Human
transcription from rna polymerase ii promoter	GO:0006366	252	0.115
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.109	Human Rat
negative regulation of macromolecule metabolic process	GO:0010605	260	0.104	Human Rat
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.092	Human
macromolecular complex subunit organization	GO:0043933	339	0.091
cellular component assembly	GO:0022607	360	0.090	Rat
regulation of programmed cell death	GO:0043067	341	0.083	Rat
regulation of molecular function	GO:0065009	398	0.083	Rat
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.082	Human
negative regulation of cellular biosynthetic process	GO:0031327	161	0.077	Human
negative regulation of metabolic process	GO:0009892	331	0.077	Human Rat
single organism reproductive process	GO:0044702	297	0.076
negative regulation of rna metabolic process	GO:0051253	123	0.071	Human Rat
cellular response to endogenous stimulus	GO:0071495	377	0.071	Rat
catabolic process	GO:0009056	351	0.069
regulation of cell differentiation	GO:0045595	320	0.069	Rat
organic acid metabolic process	GO:0006082	292	0.069
apoptotic process	GO:0006915	381	0.067	Rat
positive regulation of cell communication	GO:0010647	271	0.065
positive regulation of cell differentiation	GO:0045597	217	0.064	Rat
reproductive process	GO:0022414	372	0.063
carboxylic acid metabolic process	GO:0019752	289	0.061
brain development	GO:0007420	247	0.061
multi organism reproductive process	GO:0044703	262	0.060
neuron differentiation	GO:0030182	368	0.059	Rat
cellular response to lipid	GO:0071396	201	0.059	Rat
regulation of catalytic activity	GO:0050790	304	0.057	Rat
negative regulation of cellular metabolic process	GO:0031324	281	0.057	Human Rat
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.057	Human
negative regulation of biosynthetic process	GO:0009890	168	0.057	Human
regulation of cellular protein metabolic process	GO:0032268	267	0.056	Rat
regulation of signal transduction	GO:0009966	318	0.055
regulation of neurogenesis	GO:0050767	247	0.052	Rat
sexual reproduction	GO:0019953	148	0.052
central nervous system development	GO:0007417	311	0.051
growth	GO:0040007	165	0.050	Rat
regulation of nervous system development	GO:0051960	264	0.049	Rat
negative regulation of apoptotic process	GO:0043066	181	0.049	Rat
positive regulation of signal transduction	GO:0009967	175	0.048
cellular response to growth factor stimulus	GO:0071363	162	0.047	Rat
head development	GO:0060322	247	0.047
cellular component biogenesis	GO:0044085	368	0.047	Rat
regulation of multicellular organismal development	GO:2000026	376	0.046	Rat
cellular response to nitrogen compound	GO:1901699	210	0.046	Rat
programmed cell death	GO:0012501	392	0.045	Rat
cellular response to acid chemical	GO:0071229	75	0.044	Rat
positive regulation of developmental process	GO:0051094	283	0.044	Rat
histone h3 acetylation	GO:0043966	2	0.043	Rat
regulation of phosphorus metabolic process	GO:0051174	349	0.041	Rat
peptidyl amino acid modification	GO:0018193	126	0.041
multicellular organism reproduction	GO:0032504	233	0.040
developmental process involved in reproduction	GO:0003006	159	0.039
cell part morphogenesis	GO:0032990	123	0.039	Rat
regulation of cell development	GO:0060284	263	0.038	Rat
reproduction	GO:0000003	245	0.037
regulation of cellular component organization	GO:0051128	368	0.037	Rat
regulation of neuron differentiation	GO:0045664	208	0.037	Rat
positive regulation of programmed cell death	GO:0043068	157	0.037
tube development	GO:0035295	89	0.036	Rat
cellular response to stress	GO:0033554	269	0.035	Rat
anterior posterior pattern specification	GO:0009952	1	0.034
cellular ketone metabolic process	GO:0042180	51	0.034
cell morphogenesis	GO:0000902	142	0.034	Rat
response to oxidative stress	GO:0006979	186	0.033	Rat
organic substance catabolic process	GO:1901575	316	0.033
positive regulation of response to stimulus	GO:0048584	285	0.033	Rat
organophosphate metabolic process	GO:0019637	370	0.033
cellular response to organonitrogen compound	GO:0071417	197	0.033	Rat
multicellular organismal reproductive process	GO:0048609	233	0.033
negative regulation of transcription dna templated	GO:0045892	116	0.032	Human
regulation of cell proliferation	GO:0042127	359	0.032
response to toxic substance	GO:0009636	133	0.032	Rat
negative regulation of cell death	GO:0060548	229	0.032	Rat
response to fungicide	GO:0060992	20	0.032
carbohydrate derivative metabolic process	GO:1901135	346	0.031	Rat
positive regulation of phosphorylation	GO:0042327	177	0.031	Rat
positive regulation of multicellular organismal process	GO:0051240	387	0.031	Rat
negative regulation of programmed cell death	GO:0043069	183	0.031	Rat
cellular response to organic cyclic compound	GO:0071407	202	0.031	Rat
immune system development	GO:0002520	41	0.030
reproductive structure development	GO:0048608	128	0.030
regulation of apoptotic process	GO:0042981	335	0.030	Rat
response to growth factor	GO:0070848	189	0.030	Rat
response to acid chemical	GO:0001101	222	0.030	Rat
positive regulation of phosphate metabolic process	GO:0045937	262	0.029	Rat
cellular component morphogenesis	GO:0032989	155	0.029	Rat
cell growth	GO:0016049	104	0.029	Rat
response to wounding	GO:0009611	254	0.029
gland development	GO:0048732	155	0.029	Rat
cellular response to hormone stimulus	GO:0032870	247	0.029	Rat
response to estrogen	GO:0043627	232	0.029	Rat
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.028
regulation of cellular amino acid metabolic process	GO:0006521	2	0.028
cardiovascular system development	GO:0072358	134	0.028
eye morphogenesis	GO:0048592	4	0.028
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.028
positive regulation of molecular function	GO:0044093	230	0.028	Rat
development of primary sexual characteristics	GO:0045137	107	0.027
positive regulation of transport	GO:0051050	245	0.027	Rat
regulation of cell projection organization	GO:0031344	175	0.027	Rat
positive regulation of signaling	GO:0023056	270	0.027
neuron projection development	GO:0031175	273	0.027	Rat
developmental growth involved in morphogenesis	GO:0060560	33	0.027	Rat
homeostatic process	GO:0042592	331	0.027	Rat
cellular response to oxygen containing compound	GO:1901701	386	0.027	Rat
cellular component movement	GO:0006928	248	0.026
regulation of cellular amine metabolic process	GO:0033238	8	0.026
amine metabolic process	GO:0009308	38	0.026
regulation of protein modification process	GO:0031399	194	0.026	Rat
gamete generation	GO:0007276	124	0.025
regulation of protein metabolic process	GO:0051246	289	0.025	Rat
negative regulation of developmental process	GO:0051093	125	0.025
oxoacid metabolic process	GO:0043436	290	0.025
cell cell signaling	GO:0007267	335	0.025
positive regulation of cell development	GO:0010720	176	0.025	Rat
regulation of growth	GO:0040008	105	0.024	Rat
positive regulation of cellular amine metabolic process	GO:0033240	3	0.024
anatomical structure morphogenesis	GO:0009653	298	0.023	Rat
regulation of cellular ketone metabolic process	GO:0010565	27	0.023
ossification	GO:0001503	70	0.023
cellular amine metabolic process	GO:0044106	38	0.023
negative regulation of molecular function	GO:0044092	133	0.023	Rat
cell type specific apoptotic process	GO:0097285	134	0.023
negative regulation of neurogenesis	GO:0050768	78	0.023
protein phosphorylation	GO:0006468	345	0.022	Rat
neuron apoptotic process	GO:0051402	88	0.022
positive regulation of protein metabolic process	GO:0051247	178	0.022	Rat
regulation of neuron projection development	GO:0010975	161	0.022	Rat
cell morphogenesis involved in differentiation	GO:0000904	119	0.022	Rat
response to biotic stimulus	GO:0009607	226	0.022
locomotion	GO:0040011	237	0.022
developmental induction	GO:0031128	2	0.022
regulation of intracellular signal transduction	GO:1902531	218	0.021
organelle organization	GO:0006996	266	0.021
muscle structure development	GO:0061061	87	0.021	Rat
carbohydrate metabolic process	GO:0005975	130	0.021
regulation of phosphorylation	GO:0042325	248	0.021	Rat
forebrain development	GO:0030900	98	0.021
protein complex assembly	GO:0006461	263	0.021
positive regulation of cell proliferation	GO:0008284	249	0.021
single organism organelle organization	GO:1902589	180	0.021
intracellular signal transduction	GO:0035556	314	0.021	Rat
protein complex biogenesis	GO:0070271	263	0.021
positive regulation of nervous system development	GO:0051962	178	0.021	Rat
single organism intracellular transport	GO:1902582	166	0.021	Rat
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.020
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.020	Human
localization of cell	GO:0051674	202	0.020
positive regulation of neuron projection development	GO:0010976	99	0.020	Rat
response to reactive oxygen species	GO:0000302	120	0.020	Rat
rhythmic process	GO:0048511	156	0.020
positive regulation of cell projection organization	GO:0031346	111	0.019	Rat
neuron death	GO:0070997	127	0.019
positive regulation of neurogenesis	GO:0050769	165	0.019	Rat
developmental growth	GO:0048589	100	0.019	Rat
positive regulation of protein phosphorylation	GO:0001934	135	0.018	Rat
chemical homeostasis	GO:0048878	292	0.018	Rat
negative regulation of cell differentiation	GO:0045596	99	0.018
response to cytokine	GO:0034097	215	0.018
cell cycle	GO:0007049	101	0.018
neural crest cell differentiation	GO:0014033	2	0.018
cellular macromolecular complex assembly	GO:0034622	58	0.018	Rat
response to transforming growth factor beta	GO:0071559	46	0.018
regulation of cell growth	GO:0001558	85	0.018	Rat
positive regulation of cellular protein metabolic process	GO:0032270	167	0.018	Rat
nucleotide metabolic process	GO:0009117	279	0.017
negative regulation of multicellular organismal process	GO:0051241	203	0.017
negative regulation of signaling	GO:0023057	157	0.017
ras protein signal transduction	GO:0007265	29	0.017
organ formation	GO:0048645	3	0.017
motor neuron axon guidance	GO:0008045	1	0.017
response to other organism	GO:0051707	220	0.017
muscle cell differentiation	GO:0042692	52	0.017	Rat
cellular amino acid metabolic process	GO:0006520	107	0.017
reproductive system development	GO:0061458	128	0.017
inflammatory response	GO:0006954	150	0.017
respiratory system development	GO:0060541	45	0.017
positive regulation of cellular component organization	GO:0051130	200	0.017	Rat
sex differentiation	GO:0007548	113	0.017
regulation of cell migration	GO:0030334	128	0.017
epithelial cell differentiation	GO:0030855	71	0.017
regulation of hydrolase activity	GO:0051336	143	0.016	Rat
response to decreased oxygen levels	GO:0036293	237	0.016	Rat
regulation of neuron apoptotic process	GO:0043523	83	0.016
regulation of kinase activity	GO:0043549	117	0.016
single organism biosynthetic process	GO:0044711	342	0.016	Rat
negative regulation of cell development	GO:0010721	82	0.016
regulation of phosphate metabolic process	GO:0019220	349	0.016	Rat
intracellular transport	GO:0046907	185	0.016	Rat
secretion	GO:0046903	307	0.016	Rat
response to inorganic substance	GO:0010035	377	0.016	Rat
tube formation	GO:0035148	3	0.016
neuron development	GO:0048666	286	0.016	Rat
positive regulation of catalytic activity	GO:0043085	184	0.016
mesoderm development	GO:0007498	2	0.016
gonad development	GO:0008406	104	0.016
urogenital system development	GO:0001655	78	0.015
heart morphogenesis	GO:0003007	3	0.015
circulatory system development	GO:0072359	134	0.015
organic cyclic compound catabolic process	GO:1901361	175	0.015
regeneration	GO:0031099	163	0.015
regulation of cell morphogenesis	GO:0022604	77	0.015	Rat
regulation of protein kinase activity	GO:0045859	105	0.015
morphogenesis of embryonic epithelium	GO:0016331	3	0.015
small gtpase mediated signal transduction	GO:0007264	36	0.015
axonogenesis	GO:0007409	71	0.015	Rat
cell projection organization	GO:0030030	302	0.015	Rat
wound healing	GO:0042060	122	0.015
regulation of cellular localization	GO:0060341	263	0.015	Rat
cognition	GO:0050890	92	0.015	Rat
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.014	Rat
immune system process	GO:0002376	204	0.014
response to lipopolysaccharide	GO:0032496	191	0.014
regulation of transferase activity	GO:0051338	123	0.014
cellular response to corticosteroid stimulus	GO:0071384	69	0.014	Rat
proteolysis	GO:0006508	175	0.014	Rat
response to hydrogen peroxide	GO:0042542	89	0.014	Rat
negative regulation of neuron differentiation	GO:0045665	62	0.014
defense response	GO:0006952	194	0.014
regulation of anatomical structure morphogenesis	GO:0022603	141	0.014	Rat
negative regulation of cell communication	GO:0010648	158	0.014
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.014	Rat
regulation of cell size	GO:0008361	37	0.014	Rat
glycosyl compound metabolic process	GO:1901657	182	0.014
organ morphogenesis	GO:0009887	75	0.013
regulation of hormone levels	GO:0010817	187	0.013
signal transduction involved in regulation of gene expression	GO:0023019	4	0.013
epithelium development	GO:0060429	96	0.013
regulation of axonogenesis	GO:0050770	37	0.013	Rat
taxis	GO:0042330	67	0.013
cellular response to external stimulus	GO:0071496	118	0.013
positive regulation of protein modification process	GO:0031401	142	0.013	Rat
response to extracellular stimulus	GO:0009991	380	0.013
axon development	GO:0061564	96	0.013	Rat
regulation of anatomical structure size	GO:0090066	135	0.013	Rat
skeletal system development	GO:0001501	41	0.013
nucleobase containing small molecule metabolic process	GO:0055086	316	0.013
regulation of ossification	GO:0030278	32	0.013
regulation of catabolic process	GO:0009894	113	0.013
regulation of protein phosphorylation	GO:0001932	183	0.013	Rat
response to external biotic stimulus	GO:0043207	221	0.013
cellular catabolic process	GO:0044248	295	0.013
response to nutrient levels	GO:0031667	370	0.013
protein maturation	GO:0051604	68	0.013	Rat
lung development	GO:0030324	43	0.013
regulation of cellular component biogenesis	GO:0044087	86	0.013	Rat
gastrulation	GO:0007369	2	0.013
formation of primary germ layer	GO:0001704	1	0.013
negative regulation of protein metabolic process	GO:0051248	114	0.013	Rat
nucleoside phosphate metabolic process	GO:0006753	283	0.013
single organism catabolic process	GO:0044712	283	0.013
purine ribonucleotide metabolic process	GO:0009150	227	0.012
regulation of mesenchymal cell proliferation	GO:0010464	4	0.012
male gamete generation	GO:0048232	99	0.012
regulation of neuron death	GO:1901214	115	0.012
negative regulation of nervous system development	GO:0051961	79	0.012
nitrogen compound transport	GO:0071705	229	0.012
positive regulation of apoptotic process	GO:0043065	154	0.012
positive regulation of neuron differentiation	GO:0045666	126	0.012	Rat
digestive system development	GO:0055123	41	0.012	Rat
positive regulation of cell death	GO:0010942	184	0.012	Rat
regulation of secretion by cell	GO:1903530	208	0.012	Rat
telencephalon development	GO:0021537	62	0.012
ovulation cycle	GO:0042698	67	0.012
negative regulation of catalytic activity	GO:0043086	103	0.012	Rat
protein localization to organelle	GO:0033365	57	0.012	Rat
cell cell signaling involved in cell fate commitment	GO:0045168	2	0.012
purine containing compound metabolic process	GO:0072521	253	0.012
axis specification	GO:0009798	4	0.012
ribose phosphate metabolic process	GO:0019693	235	0.012
carbohydrate homeostasis	GO:0033500	75	0.012	Rat
embryonic pattern specification	GO:0009880	1	0.012
peptidyl tyrosine modification	GO:0018212	72	0.012
response to estradiol	GO:0032355	164	0.012
neural crest cell development	GO:0014032	2	0.012
macromolecular complex assembly	GO:0065003	273	0.012	Rat
purine nucleoside metabolic process	GO:0042278	169	0.012
spermatogenesis	GO:0007283	99	0.012
cellular response to oxidative stress	GO:0034599	76	0.012	Rat
macromolecule localization	GO:0033036	252	0.012	Rat
hematopoietic progenitor cell differentiation	GO:0002244	2	0.012
peptidyl tyrosine phosphorylation	GO:0018108	72	0.012
aging	GO:0007568	241	0.012
mammary gland epithelium development	GO:0061180	1	0.012
negative regulation of cell proliferation	GO:0008285	119	0.012
cation homeostasis	GO:0055080	195	0.012
single organism behavior	GO:0044708	130	0.011	Rat
regulation of locomotion	GO:0040012	148	0.011
protein processing	GO:0016485	68	0.011	Rat
pallium development	GO:0021543	42	0.011
response to carbohydrate	GO:0009743	183	0.011	Rat
cardiac ventricle development	GO:0003231	1	0.011
chemotaxis	GO:0006935	66	0.011
organic hydroxy compound metabolic process	GO:1901615	115	0.011
cellular nitrogen compound catabolic process	GO:0044270	163	0.011
regulation of canonical wnt signaling pathway	GO:0060828	4	0.011
multicellular organism growth	GO:0035264	1	0.011
hemopoiesis	GO:0030097	34	0.011
rho protein signal transduction	GO:0007266	11	0.011
negative regulation of cell cycle phase transition	GO:1901988	4	0.011
mesenchymal cell proliferation	GO:0010463	4	0.011
single organism carbohydrate metabolic process	GO:0044723	118	0.011
mapk cascade	GO:0000165	140	0.011
positive regulation of intracellular signal transduction	GO:1902533	138	0.011
positive regulation of phosphorus metabolic process	GO:0010562	262	0.010	Rat
signal transduction by phosphorylation	GO:0023014	144	0.010
purine nucleotide catabolic process	GO:0006195	136	0.010
cellular ion homeostasis	GO:0006873	184	0.010
vasculature development	GO:0001944	70	0.010
response to insulin	GO:0032868	133	0.010
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.010
appendage morphogenesis	GO:0035107	4	0.010
protein oligomerization	GO:0051259	191	0.010
connective tissue development	GO:0061448	33	0.010
signal release	GO:0023061	145	0.010
cell projection morphogenesis	GO:0048858	123	0.010	Rat
response to ketone	GO:1901654	182	0.010	Rat
camera type eye development	GO:0043010	48	0.010
regulation of peptide transport	GO:0090087	87	0.010
dna metabolic process	GO:0006259	96	0.010
carbohydrate derivative biosynthetic process	GO:1901137	124	0.010	Rat
metal ion homeostasis	GO:0055065	186	0.010
response to interleukin 1	GO:0070555	55	0.010
cellular response to steroid hormone stimulus	GO:0071383	93	0.010	Rat
regulation of cytoskeleton organization	GO:0051493	49	0.010	Rat
response to retinoic acid	GO:0032526	63	0.010	Rat
male sex differentiation	GO:0046661	64	0.010

Crebbp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	nervous system disease	DOID:863	0	0.013
	disease of anatomical entity	DOID:7	0	0.013

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