Rattus norvegicus

189 known processes

Slc8a1

solute carrier family 8 (sodium/calcium exchanger), member 1

(Aliases: Ncx,Ncx1)

Slc8a1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cation transmembrane transportGO:00986552630.731
cellular component movementGO:00069282480.721
cellular chemical homeostasisGO:00550822470.602
inorganic cation transmembrane transportGO:00986622020.584
cation homeostasisGO:00550801950.467
regulation of ion transportGO:00432692450.447
cellular metal ion homeostasisGO:00068751720.428
cellular response to endogenous stimulusGO:00714953770.348
sodium ion transmembrane transportGO:0035725670.344
metal ion homeostasisGO:00550651860.316
cell cell signalingGO:00072673350.309
metal ion transportGO:00300012890.308
chemical homeostasisGO:00488782920.298
monovalent inorganic cation transportGO:00156721720.297
cellular homeostasisGO:00197252520.285
single organism catabolic processGO:00447122830.275
response to nutrient levelsGO:00316673700.243
carboxylic acid metabolic processGO:00197522890.240
regulation of hormone secretionGO:00468831060.236
cation transportGO:00068123820.223
blood circulationGO:00080151830.222
cardiovascular system developmentGO:00723581340.215
cellular response to oxygen containing compoundGO:19017013860.211
regulation of cardiac muscle contractionGO:0055117170.208
striated muscle contractionGO:0006941440.207
regulation of system processGO:00440572080.207
regulation of sodium ion transmembrane transporter activityGO:200064940.205
regulation of striated muscle contractionGO:0006942210.200
homeostatic processGO:00425923310.198
transmembrane transportGO:00550854120.194
regulation of molecular functionGO:00650093980.193
cellular response to peptideGO:19016531330.193
circulatory system developmentGO:00723591340.189
g protein coupled receptor signaling pathwayGO:00071862420.185
muscle contractionGO:0006936880.183
cellular ion homeostasisGO:00068731840.181
lipid biosynthetic processGO:00086101280.174
cellular response to lipidGO:00713962010.173
mapk cascadeGO:00001651400.169
positive regulation of locomotionGO:00400171020.163
growthGO:00400071650.158
regulation of cellular localizationGO:00603412630.158
actin mediated cell contractionGO:0070252120.157
rhythmic processGO:00485111560.156
positive regulation of multicellular organismal processGO:00512403870.155
negative regulation of apoptotic processGO:00430661810.152
positive regulation of cell communicationGO:00106472710.151
regulation of multicellular organismal developmentGO:20000263760.150
single organism biosynthetic processGO:00447113420.149
ion homeostasisGO:00508012120.149
regulation of catalytic activityGO:00507903040.148
regulation of programmed cell deathGO:00430673410.146
secretionGO:00469033070.146
positive regulation of nervous system developmentGO:00519621780.145
intracellular signal transductionGO:00355563140.145
inorganic ion transmembrane transportGO:00986602290.142
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:001088040.142
neuron differentiationGO:00301823680.141
cellular response to peptide hormone stimulusGO:00713751200.140
cellular response to insulin stimulusGO:0032869810.140
divalent metal ion transportGO:00708381320.136
sodium ion transportGO:0006814820.136
programmed cell deathGO:00125013920.132
divalent inorganic cation homeostasisGO:00725071650.132
tissue developmentGO:00098882520.131
regulation of metal ion transportGO:00109591180.129
protein phosphorylationGO:00064683450.124
positive regulation of developmental processGO:00510942830.124
positive regulation of phosphate metabolic processGO:00459372620.124
enzyme linked receptor protein signaling pathwayGO:00071671160.120
head developmentGO:00603222470.116
cellular response to organonitrogen compoundGO:00714171970.116
regulation of hormone levelsGO:00108171870.115
circulatory system processGO:00030131830.112
regulation of homeostatic processGO:00328441010.111
regulation of signal transductionGO:00099663180.111
cellular response to hormone stimulusGO:00328702470.111
positive regulation of cell differentiationGO:00455972170.110
regulation of blood circulationGO:19035221100.109
synaptic transmissionGO:00072682350.109
brain developmentGO:00074202470.103
ion transmembrane transportGO:00342203650.103
regulation of cellular component organizationGO:00511283680.103
calcium ion transportGO:00068161310.100
organic cyclic compound catabolic processGO:19013611750.099
regulation of secretionGO:00510462240.099
response to insulinGO:00328681330.098
regulation of phosphorylationGO:00423252480.097
organ morphogenesisGO:0009887750.095
cellular response to ketoneGO:1901655510.095
regulation of apoptotic processGO:00429813350.094
regulation of lipid metabolic processGO:0019216680.093
positive regulation of response to stimulusGO:00485842850.092
oxoacid metabolic processGO:00434362900.092
response to ketoneGO:19016541820.091
cardiac muscle cell contractionGO:0086003100.091
positive regulation of signalingGO:00230562700.090
carbohydrate derivative metabolic processGO:19011353460.090
steroid metabolic processGO:0008202730.090
response to external biotic stimulusGO:00432072210.089
regulation of transcription dna templatedGO:00063553740.087
negative regulation of cell deathGO:00605482290.086
catabolic processGO:00090563510.086
single organism carbohydrate metabolic processGO:00447231180.086
reproductive structure developmentGO:00486081280.086
behaviorGO:00076102050.086
positive regulation of signal transductionGO:00099671750.084
muscle system processGO:00030121150.084
cellular divalent inorganic cation homeostasisGO:00725031620.083
negative regulation of metabolic processGO:00098923310.082
response to dexamethasoneGO:0071548490.081
nucleic acid templated transcriptionGO:00976593790.080
calcium ion importGO:0070509220.079
oxidation reduction processGO:00551143040.079
positive regulation of phosphorylationGO:00423271770.078
signal releaseGO:00230611450.078
cellular component morphogenesisGO:00329891550.077
negative regulation of cellular metabolic processGO:00313242810.077
regulation of secretion by cellGO:19035302080.077
defense responseGO:00069521940.077
regulation of ion transmembrane transportGO:00347651210.076
generation of precursor metabolites and energyGO:0006091620.076
reproductive system developmentGO:00614581280.076
response to extracellular stimulusGO:00099913800.076
regulation of cellular component movementGO:00512701500.076
peptidyl amino acid modificationGO:00181931260.075
steroid biosynthetic processGO:0006694480.075
organic substance catabolic processGO:19015753160.075
positive regulation of cytosolic calcium ion concentrationGO:00072041220.075
negative regulation of transportGO:00510511360.074
epithelium developmentGO:0060429960.074
regulation of cellular ketone metabolic processGO:0010565270.073
tube developmentGO:0035295890.073
response to peptide hormoneGO:00434342780.073
lipid metabolic processGO:00066292830.073
rna metabolic processGO:00160704060.073
amide transportGO:00428861050.072
response to corticosteroidGO:00319602350.072
response to cytokineGO:00340972150.072
regulation of protein metabolic processGO:00512462890.070
regulation of transmembrane transportGO:00347621220.070
cell motilityGO:00488702020.069
negative regulation of programmed cell deathGO:00430691830.068
regulation of cell developmentGO:00602842630.068
regulation of phosphate metabolic processGO:00192203490.067
transcription from rna polymerase ii promoterGO:00063662520.067
neuron developmentGO:00486662860.066
response to campGO:0051591910.066
response to peptideGO:19016522920.066
response to vitamin dGO:0033280340.066
gonad developmentGO:00084061040.065
regulation of phosphorus metabolic processGO:00511743490.065
heart developmentGO:0007507720.065
transcription dna templatedGO:00063513770.064
regulation of cardiac muscle contraction by calcium ion signalingGO:001088230.063
lipid modificationGO:0030258520.063
positive regulation of molecular functionGO:00440932300.063
intracellular transportGO:00469071850.063
regulation of cardiac muscle cell contractionGO:0086004110.062
response to biotic stimulusGO:00096072260.062
immune effector processGO:0002252530.062
regulation of actin filament based movementGO:1903115120.061
reproductionGO:00000032450.061
regulation of synaptic transmissionGO:00508041410.061
positive regulation of intracellular signal transductionGO:19025331380.060
cellular cation homeostasisGO:00300031800.060
adult locomotory behaviorGO:000834440.060
cellular catabolic processGO:00442482950.060
apoptotic processGO:00069153810.060
development of primary sexual characteristicsGO:00451371070.059
organonitrogen compound catabolic processGO:19015651790.059
epithelial cell differentiationGO:0030855710.059
regulation of nervous system developmentGO:00519602640.058
regulation of cell proliferationGO:00421273590.057
heart processGO:0003015570.057
release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:001480840.057
single organism behaviorGO:00447081300.057
monosaccharide metabolic processGO:0005996610.056
cellular amino acid metabolic processGO:00065201070.056
cellular ketone metabolic processGO:0042180510.056
cellular response to alcoholGO:0097306870.056
single organism intracellular transportGO:19025821660.055
regulation of calcium ion transportGO:0051924770.055
negative regulation of response to stimulusGO:00485851550.054
cytosolic calcium ion homeostasisGO:00514801400.054
response to oxygen levelsGO:00704822650.054
single organism reproductive processGO:00447022970.054
cellular response to nitrogen compoundGO:19016992100.053
regulation of anatomical structure morphogenesisGO:00226031410.053
regulation of sodium ion transportGO:0002028210.053
regulation of rna biosynthetic processGO:20011413810.053
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.052
cellular response to metal ionGO:0071248550.052
actin filament based movementGO:0030048160.052
regulation of ion transmembrane transporter activityGO:0032412480.052
muscle cell proliferationGO:0033002840.051
regulation of immune system processGO:00026821230.051
hormone transportGO:00099141210.051
inflammatory responseGO:00069541500.051
sympathetic nervous system developmentGO:004848510.051
female gonad developmentGO:0008585530.051
calcium ion homeostasisGO:00550741620.051
positive regulation of neuron differentiationGO:00456661260.051
neurotransmitter transportGO:0006836420.051
heart contractionGO:0060047570.051
positive regulation of cellular component movementGO:00512721020.050
regulation of transporter activityGO:0032409500.050
positive regulation of cell deathGO:00109421840.050
organic acid metabolic processGO:00060822920.049
response to monosaccharideGO:00342841590.048
cellular calcium ion homeostasisGO:00068741600.048
response to other organismGO:00517072200.048
carbohydrate homeostasisGO:0033500750.048
glucose homeostasisGO:0042593750.048
cellular lipid metabolic processGO:00442552080.047
cell growthGO:00160491040.047
organophosphate metabolic processGO:00196373700.047
response to glucocorticoidGO:00513842230.046
regulation of protein phosphorylationGO:00019321830.046
response to estrogenGO:00436272320.046
response to toxic substanceGO:00096361330.046
positive regulation of cell developmentGO:00107201760.046
neuron projection developmentGO:00311752730.046
regulation of hydrolase activityGO:00513361430.045
regulation of cellular amino acid metabolic processGO:000652120.045
positive regulation of neurogenesisGO:00507691650.045
regulation of muscle system processGO:0090257790.044
cellular response to stressGO:00335542690.044
carbohydrate metabolic processGO:00059751300.044
second messenger mediated signalingGO:0019932510.044
positive regulation of phosphorus metabolic processGO:00105622620.044
cell morphogenesisGO:00009021420.044
cellular amine metabolic processGO:0044106380.043
hormone secretionGO:00468791150.043
positive regulation of biosynthetic processGO:00098913190.042
circadian sleep wake cycle sleepGO:0050802210.042
peptide hormone secretionGO:0030072840.042
response to acid chemicalGO:00011012220.042
purine nucleotide metabolic processGO:00061632290.041
positive regulation of nitrogen compound metabolic processGO:00511733340.041
regulation of locomotionGO:00400121480.041
negative regulation of macromolecule metabolic processGO:00106052600.041
insulin like growth factor receptor signaling pathwayGO:004800930.041
sensory perceptionGO:00076001010.041
cellular response to organic cyclic compoundGO:00714072020.041
regulation of cell growthGO:0001558850.041
amine metabolic processGO:0009308380.040
positive regulation of rna biosynthetic processGO:19026801970.040
jak stat cascadeGO:0007259260.040
reproductive processGO:00224143720.040
response to bacteriumGO:00096172000.040
taxisGO:0042330670.040
cellular glucan metabolic processGO:0006073230.039
rna biosynthetic processGO:00327743800.039
alpha amino acid metabolic processGO:1901605710.039
divalent inorganic cation transportGO:00725111340.038
regulation of growthGO:00400081050.038
regulation of cellular amine metabolic processGO:003323880.038
cardiac muscle contractionGO:0060048270.038
endoplasmic reticulum to cytosol transportGO:190351340.037
regulation of transferase activityGO:00513381230.037
response to inorganic substanceGO:00100353770.037
negative regulation of biosynthetic processGO:00098901680.037
regulation of nucleic acid templated transcriptionGO:19035063800.037
regulation of neuron projection developmentGO:00109751610.037
regulation of blood pressureGO:0008217830.037
negative regulation of protein metabolic processGO:00512481140.037
regulation of protein kinase activityGO:00458591050.037
positive regulation of cellular component organizationGO:00511302000.036
regulation of cell differentiationGO:00455953200.036
axon guidanceGO:0007411240.036
calcium mediated signalingGO:0019722230.036
organ growthGO:0035265240.036
multicellular organismal reproductive processGO:00486092330.036
regulation of tube sizeGO:0035150890.036
monocarboxylic acid metabolic processGO:00327871520.036
small molecule biosynthetic processGO:00442831240.035
response to hydrogen peroxideGO:0042542890.035
signal transduction by phosphorylationGO:00230141440.035
regulation of intracellular signal transductionGO:19025312180.035
positive regulation of hormone secretionGO:0046887650.035
regulation of kinase activityGO:00435491170.035
cytoplasmic transportGO:00164821150.035
positive regulation of macromolecule biosynthetic processGO:00105572470.035
regulation of neuron differentiationGO:00456642080.035
nitrogen compound transportGO:00717052290.034
regulation of neurogenesisGO:00507672470.034
ras protein signal transductionGO:0007265290.033
secretion by cellGO:00329402480.033
cellular hormone metabolic processGO:0034754490.033
neurological system processGO:00508772190.033
positive regulation of nucleoside metabolic processGO:0045979550.033
anatomical structure morphogenesisGO:00096532980.033
localization of cellGO:00516742020.033
central nervous system developmentGO:00074173110.033
sex differentiationGO:00075481130.032
digestive system developmentGO:0055123410.032
tissue morphogenesisGO:0048729220.032
learning or memoryGO:0007611900.032
regulation of peptide hormone secretionGO:0090276800.032
cellular carbohydrate metabolic processGO:0044262720.032
small gtpase mediated signal transductionGO:0007264360.031
response to vitaminGO:00332731310.031
positive regulation of transcription dna templatedGO:00458931970.031
negative regulation of signalingGO:00230571570.031
energy reserve metabolic processGO:0006112250.031
behavioral response to nicotineGO:003509520.031
anatomical structure formation involved in morphogenesisGO:0048646830.031
response to fatty acidGO:0070542650.030
cellular response to glucocorticoid stimulusGO:0071385680.030
positive regulation of catalytic activityGO:00430851840.030
single organism carbohydrate catabolic processGO:0044724400.030
response to ethanolGO:00454711620.030
positive regulation of transcription factor import into nucleusGO:004299340.030
vesicle mediated transportGO:00161921810.030
agingGO:00075682410.030
calcium ion transmembrane transportGO:0070588700.030
regulation of heart contractionGO:0008016480.030
positive regulation of kinase activityGO:0033674770.030
organophosphate catabolic processGO:00464341480.030
lipid catabolic processGO:0016042460.029
regulation of phosphatidylinositol dephosphorylationGO:006030410.029
carbohydrate derivative catabolic processGO:19011361470.029
developmental process involved in reproductionGO:00030061590.029
male gonad developmentGO:0008584590.029
development of primary female sexual characteristicsGO:0046545560.029
macromolecular complex assemblyGO:00650032730.029
response to growth factorGO:00708481890.029
positive regulation of nucleic acid templated transcriptionGO:19035081970.028
protein complex biogenesisGO:00702712630.028
regulation of cell motilityGO:20001451310.028
negative regulation of protein phosphorylationGO:0001933440.028
negative regulation of nitrogen compound metabolic processGO:00511721610.028
cellular nitrogen compound catabolic processGO:00442701630.028
female pregnancyGO:00075651220.028
neuron apoptotic processGO:0051402880.027
response to decreased oxygen levelsGO:00362932370.027
response to light stimulusGO:0009416520.027
positive regulation of transportGO:00510502450.027
organonitrogen compound biosynthetic processGO:19015661670.027
regulation of blood vessel sizeGO:0050880890.027
regulation of peptide secretionGO:0002791820.027
negative regulation of ion transportGO:0043271510.027
glucan metabolic processGO:0044042230.027
macromolecule localizationGO:00330362520.027
salivary gland developmentGO:000743130.027
regulation of insulin secretionGO:0050796650.027
negative regulation of molecular functionGO:00440921330.027
regulation of lipid biosynthetic processGO:0046890380.027
response to interleukin 1GO:0070555550.027
kidney developmentGO:0001822670.027
maintenance of locationGO:0051235170.027
circadian rhythmGO:0007623880.026
response to transition metal nanoparticleGO:19902671220.026
cellular response to growth factor stimulusGO:00713631620.026
regulation of anatomical structure sizeGO:00900661350.026
autonomic nervous system developmentGO:004848330.026
cellular response to cytokine stimulusGO:00713451270.026
response to hypoxiaGO:00016662310.026
biological adhesionGO:00226101100.026
response to estradiolGO:00323551640.026
adult behaviorGO:0030534160.026
positive regulation of cellular amino acid metabolic processGO:004576410.026
regulation of transmembrane transporter activityGO:0022898490.026
nucleobase containing small molecule metabolic processGO:00550863160.026
multicellular organism reproductionGO:00325042330.026
regulation of peptide transportGO:0090087870.025
vasodilationGO:0042311440.025
protein targetingGO:0006605610.025
cell projection organizationGO:00300303020.025
hematopoietic progenitor cell differentiationGO:000224420.025
cell cycleGO:00070491010.025
regulation of catabolic processGO:00098941130.025
calcium ion transport from endoplasmic reticulum to cytosolGO:190351440.025
purine ribonucleoside triphosphate metabolic processGO:00092051400.025
organic hydroxy compound transportGO:0015850770.025
purine containing compound metabolic processGO:00725212530.025
neuromuscular synaptic transmissionGO:000727420.025
negative regulation of cellular protein metabolic processGO:00322691060.025
developmental growthGO:00485891000.025
cellular component assemblyGO:00226073600.025
response to amino acidGO:0043200750.024
morphogenesis of an epitheliumGO:0002009200.024
response to hexoseGO:00097461440.024
locomotionGO:00400112370.024
sarcoplasmic reticulum calcium ion transportGO:007029680.024
intracellular protein transportGO:0006886790.024
phospholipid metabolic processGO:0006644610.024
nucleotide metabolic processGO:00091172790.024
response to radiationGO:00093141370.024
telencephalon developmentGO:0021537620.024
negative regulation of cell communicationGO:00106481580.024
multi organism reproductive processGO:00447032620.024
multicellular organism growthGO:003526410.024
insulin secretionGO:0030073690.024
negative regulation of innate immune responseGO:004582440.023
dendrite developmentGO:0016358720.023
regulation of dendrite developmentGO:0050773590.023
reactive nitrogen species metabolic processGO:200105710.023
ribonucleotide catabolic processGO:00092611360.023
positive regulation of immune system processGO:0002684900.023
cellular response to external stimulusGO:00714961180.023
negative regulation of gene expressionGO:00106291990.023
aromatic compound catabolic processGO:00194391680.023
regulation of membrane potentialGO:00423911100.023
small molecule catabolic processGO:0044282590.023
single organism membrane organizationGO:0044802740.022
vascular process in circulatory systemGO:0003018960.022
nucleoside phosphate catabolic processGO:19012921400.022
response to corticosteroneGO:0051412400.022
regulation of cell cycleGO:0051726730.022
regulation of protein modification processGO:00313991940.022
ribonucleotide metabolic processGO:00092592310.022
positive regulation of nucleobase containing compound metabolic processGO:00459353190.022
regulation of cellular protein metabolic processGO:00322682670.022
positive regulation of protein modification processGO:00314011420.022
response to temperature stimulusGO:0009266940.022
heterocycle catabolic processGO:00467001670.022
positive regulation of cell motilityGO:2000147970.022
positive regulation of gene expressionGO:00106282440.021
negative regulation of secretion by cellGO:1903531720.021
androgen metabolic processGO:0008209140.021
positive regulation of cellular amine metabolic processGO:003324030.021
neuron projection guidanceGO:0097485240.021
organ formationGO:004864530.021
reactive oxygen species metabolic processGO:0072593370.021
positive regulation of protein metabolic processGO:00512471780.021
regulation of transcription from rna polymerase ii promoterGO:00063572340.021
response to nutrientGO:00075842480.021
regulation of neuron deathGO:19012141150.021
negative regulation of natural killer cell mediated immunityGO:000271640.021
glycogen metabolic processGO:0005977230.021
negative regulation of natural killer cell mediated cytotoxicityGO:004595340.021
blood vessel morphogenesisGO:0048514580.021
positive regulation of vasodilationGO:0045909290.021
positive regulation of secretion by cellGO:19035321280.021
response to carbohydrateGO:00097431830.021
regulation of epithelial cell proliferationGO:0050678490.020
positive regulation of renin secretion into blood streamGO:190013510.020
regulation of muscle contractionGO:0006937530.020
ossificationGO:0001503700.020
negative regulation of secretionGO:0051048820.020
phospholipase c activating g protein coupled receptor signaling pathwayGO:0007200270.020
cellular amide metabolic processGO:0043603440.020
peptidyl serine phosphorylationGO:0018105330.020
regulation of cell killingGO:0031341120.020
membrane organizationGO:0061024940.020
organelle organizationGO:00069962660.020
regulation of smooth muscle cell proliferationGO:0048660750.020
urogenital system developmentGO:0001655780.020
regulation of cell projection organizationGO:00313441750.020
renin secretion into blood streamGO:000200110.020
negative regulation of transporter activityGO:0032410130.020
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.020
nucleoside phosphate metabolic processGO:00067532830.019
gland developmentGO:00487321550.019
cell adhesionGO:00071551100.019
potassium ion transportGO:0006813970.019
cellular response to steroid hormone stimulusGO:0071383930.019
positive regulation of endothelial cell migrationGO:001059540.019
positive regulation of mapk cascadeGO:0043410920.019
protein complex assemblyGO:00064612630.019
regulation of systemic arterial blood pressure by norepinephrine epinephrineGO:000199320.019
positive regulation of cellular protein metabolic processGO:00322701670.019
response to metal ionGO:00100382530.019
salivary gland morphogenesisGO:000743510.019
cardiac muscle cell action potentialGO:008600150.019
multicellular organismal homeostasisGO:0048871490.019
immune responseGO:00069551040.019
ovulation cycleGO:0042698670.019
response to lipopolysaccharideGO:00324961910.019
nucleoside triphosphate catabolic processGO:00091431230.019
mammary gland epithelium developmentGO:006118010.019
positive regulation of neuron projection developmentGO:0010976990.019
secretion by tissueGO:0032941370.018
female sex differentiationGO:0046660590.018
ovulation cycle processGO:0022602500.018
regulation of ossificationGO:0030278320.018
single organismal cell cell adhesionGO:0016337420.018
peptidyl tyrosine modificationGO:0018212720.018
nucleoside triphosphate metabolic processGO:00091411440.018
hexose metabolic processGO:0019318580.018
axon developmentGO:0061564960.018
gastrulationGO:000736920.018
cellular response to glucose stimulusGO:0071333650.018
cellular response to hexose stimulusGO:0071331650.018
amide biosynthetic processGO:0043604100.018
peptide secretionGO:0002790860.018
protein transportGO:00150311320.018

Slc8a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
central nervous system diseaseDOID:33100.084
disease of anatomical entityDOID:700.084
nervous system diseaseDOID:86300.084
disease of metabolismDOID:001466700.043
inherited metabolic disorderDOID:65500.037
brain diseaseDOID:93600.029
epilepsy syndromeDOID:182600.022